PIWIL1

Summary

Gene Symbol: PIWIL1
Description: piwi like RNA-mediated gene silencing 1
Alias: CT80.1, HIWI, MIWI, PIWI, piwi-like protein 1, piwi homolog
Species: human
Products:     PIWIL1

Top Publications

  1. Cox D, Chao A, Baker J, Chang L, Qiao D, Lin H. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev. 1998;12:3715-27 pubmed
    ..We cloned and characterized the Drosophila piwi gene and showed that it is required for the asymmetric division of GSCs to produce and maintain a daughter GSC but ..
  2. Qiao D, Zeeman A, Deng W, Looijenga L, Lin H. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene. 2002;21:3988-99 pubmed
    The piwi family genes are highly conserved during evolution and play essential roles in stem cell self-renewal, gametogenesis, and RNA interference in diverse organisms ranging from Drosophila melanogaster and C. elegans to Arabidopsis...
  3. Liu X, Sun Y, Guo J, Ma H, Li J, Dong B, et al. Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer. 2006;118:1922-9 pubmed
    ..Recent discoveries have indicated that the piwi family of genes plays an essential role in stem cell self-renewal in diverse organisms...
  4. Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, Nagase T, et al. The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus. Biochem Biophys Res Commun. 2007;359:497-502 pubmed
    ..However, little is known about the key proteins. Here, we report that the human PIWI-like family is a candidate protein that is involved in the pathway responsible for chromatin remodeling...
  5. Liu C, Qu L, Dong B, Xing X, Ren T, Zeng Y, et al. Combined phenotype of 4 markers improves prognostic value of patients with colon cancer. Am J Med Sci. 2012;343:295-302 pubmed publisher
    ..subgroups of colon adenocarcinoma by combined analysis of synuclein-gamma (SNCG), a human homologue of piwi (Hiwi), phosphatase of regenerating liver-3 (PRL-3), arrest-defective protein 1, homolog A (ARD1) and clinicopathologic ..
  6. Sharma A, Nelson M, Brandt J, Wessman M, Mahmud N, Weller K, et al. Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. Blood. 2001;97:426-34 pubmed
    ..This study demonstrated that hiwi, a novel human homologue of piwi, is also present in human CD34(+) hematopoietic progenitor cells but not in more ..
  7. Sasaki T, Shiohama A, Minoshima S, Shimizu N. Identification of eight members of the Argonaute family in the human genome. Genomics. 2003;82:323-30 pubmed
    ..comparison, eight members of the Argonaute family were classified into two subfamilies: the PIWI subfamily (PIWIL1/HIWI, PIWIL2/HILI, PIWIL3, and PIWIL4/HIWI2) and the eIF2C/AGO subfamily (EIF2C1/hAGO1, EIF2C2/hAGO2, EIF2C3/hAGO3,..
  8. Grochola L, Greither T, Taubert H, Moller P, Knippschild U, Udelnow A, et al. The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br J Cancer. 2008;99:1083-8 pubmed publisher
    b>Piwi proteins and their interaction with piRNAs have rapidly emerged as important contributors to gene regulation, indicating their crucial function in germline and stem cell development...
  9. He W, Wang Z, Wang Q, Fan Q, Shou C, Wang J, et al. Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis. BMC Cancer. 2009;9:426 pubmed publisher
    b>HIWI, the human homologue of Piwi family, is present in CD34+ hematopoietic stem cells and germ cells, but not in well-differentiated cell populations, indicating that HIWI may play an impotent role in determining or maintaining stemness ..

More Information

Publications131 found, 100 shown here

  1. Taubert H, Greither T, Kaushal D, Wurl P, Bache M, Bartel F, et al. Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. Oncogene. 2007;26:1098-100 pubmed
    ..Dysregulation of stem cell self-renewal is likely a requirement for the development of cancer. Hiwi, the human Piwi gene, encodes a protein responsible for stem cell self-renewal...
  2. Siddiqi S, Terry M, Matushansky I. Hiwi mediated tumorigenesis is associated with DNA hypermethylation. PLoS ONE. 2012;7:e33711 pubmed publisher
    ..Piwi's genomic protective function conflicts with reports that its human ortholog, Hiwi, is expressed in numerous cancers and prognosticates shorter survival...
  3. Kwon C, Tak H, Rho M, Chang H, Kim Y, Kim K, et al. Detection of PIWI and piRNAs in the mitochondria of mammalian cancer cells. Biochem Biophys Res Commun. 2014;446:218-23 pubmed publisher
    ..Further validation showed detection of Piwi by colocalization using anti-Piwil1 and mitochondria organelle-specific protein antibodies.
  4. Reeves M, Baldwin M, Aragon R, Baldwin S, Chen S, Li X, et al. RASSF1C modulates the expression of a stem cell renewal gene, PIWIL1. BMC Res Notes. 2012;5:239 pubmed publisher
    ..We demonstrate that RASSF1C over-expression increases, and silencing of RASSF1C decreases, the expression of PIWIL1 gene in NSCLC cells using qRT-PCR, immunostaining, and Western blot analysis...
  5. Selvaraju S, Parthipan S, Somashekar L, Binsila B, Kolte A, Arangasamy A, et al. Current status of sperm functional genomics and its diagnostic potential of fertility in bovine (Bos taurus). Syst Biol Reprod Med. 2018;64:484-501 pubmed publisher
    ..AI: artificial insemination; BSE: breeding soundness evaluation; cfs-mRNA: cell-free seminal mRNA; piRNA: PIWI-interacting RNA; tRNA: transfer RNA; fg: femtogram; TPM: transcripts per million reads; RPKM: reads per kilobase ..
  6. Pierce L, Kurata W, Matsumoto K, Clark M, Farmer D. Long-term epigenetic alterations in a rat model of Gulf War Illness. Neurotoxicology. 2016;55:20-32 pubmed publisher
    ..GW-relevant exposures also induced the differential expression of two piwi-interacting RNAs (piRNAs) in circulation (piR-007899 and piR-019162)...
  7. Liu P, Dong Y, Gu J, Puthiyakunnon S, Wu Y, Chen X. Developmental piRNA profiles of the invasive vector mosquito Aedes albopictus. Parasit Vectors. 2016;9:524 pubmed
    In eukaryotic organisms, Piwi-interacting RNAs (piRNAs) control the activities of mobile genetic elements and ensure genome maintenance...
  8. Garcia Fabiani M, Montanaro M, Lacunza E, Cattaneo E, Coleman R, Pellon Maison M, et al. Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis. Biochem J. 2015;471:211-20 pubmed publisher
    ..New data show that GPAT2 is required for the synthesis of piRNAs (piwi-interacting RNAs), a group of small RNAs that protect the germ cell genome from retrotransposable elements...
  9. Campanini E, Vandewege M, Pillai N, Tay B, Jones J, Venkatesh B, et al. Early Evolution of Vertebrate Mybs: An Integrative Perspective Combining Synteny, Phylogenetic, and Gene Expression Analyses. Genome Biol Evol. 2015;7:3009-21 pubmed publisher
    ..c-Myb is involved in hematopoiesis, and A-Myb is involved in spermatogenesis and regulating expression of pachytene PIWI interacting RNAs, a class of small RNAs involved in posttranscriptional gene regulation and the maintenance of ..
  10. Green D, Fraser W, Dalmay T. Transfer RNA-derived small RNAs in the cancer transcriptome. Pflugers Arch. 2016;468:1041-7 pubmed publisher
    ..RNA silencing studies predominantly focus on small RNAs such as microRNAs, short-interfering RNAs and piwi-interacting RNAs. We describe an emerging renewal of interest in a 'larger' small RNA, the transfer RNA (tRNA)...
  11. Hyams Y, Paz G, Rabinowitz C, Rinkevich B. Insights into the unique torpor of Botrylloides leachi, a colonial urochordate. Dev Biol. 2017;428:101-117 pubmed publisher
    ..At the outset of hibernation we documented high expression levels of PIWI, PL-10 and PCNA in cells residing in cell islands (CIs), which are the specific stem cell niches found along the ..
  12. Waldron F, Stone G, Obbard D. Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes. PLoS Genet. 2018;14:e1007533 pubmed publisher
    ..in any of the animals, despite the widespread presence of abundant micro-RNAs, and somatic transposon-derived piwi-interacting RNAs. We did identify a distinctive group of small RNAs derived from RNA viruses in the mollusc...
  13. Li P, Yan G, Han L, Pang J, Zhong B, Zhang G, et al. Overexpression of STRA8, BOULE, and DAZL Genes Promotes Goat Bone Marrow-Derived Mesenchymal Stem Cells In Vitro Transdifferentiation Toward Putative Male Germ Cells. Reprod Sci. 2017;24:300-312 pubmed publisher
    ..C-KIT (tyrosine kinase receptor) as well as premeiotic genes MVH (mouse vasa homolog), DAZL, BOULE, STRA8, PIWIL2 (piwi-like RNA-mediated gene silencing 2), and RNF17 (ring finger protein 17)...
  14. Leng X, Ma J, Liu Y, Shen S, Yu H, Zheng J, et al. Mechanism of piR-DQ590027/MIR17HG regulating the permeability of glioma conditioned normal BBB. J Exp Clin Cancer Res. 2018;37:246 pubmed publisher
    ..the effects of noncoding RNA on the permeability of glioma conditioned normal BBB and the mechanism involved using PIWI-associated RNA piR-DQ590027 as a starting point...
  15. Papanikos F, Daniel K, Goercharn Ramlal A, Fei J, Kurth T, Wojtasz L, et al. The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice. Chromosoma. 2017;126:399-415 pubmed publisher
    ..The dense body contains small non-coding RNAs including microRNAs and PIWI-associated RNAs...
  16. Lee S, Kong M, Harrison P, Hijri M. Conserved Proteins of the RNA Interference System in the Arbuscular Mycorrhizal Fungus Rhizoglomus irregulare Provide New Insight into the Evolutionary History of Glomeromycota. Genome Biol Evol. 2018;10:328-343 pubmed publisher
    ..family enzymes are important in small RNA regulation in Fungi together with two additional core proteins (Argonaute/piwi and RdRP)...
  17. Gandhi S, Bag I, Sengupta S, Pal Bhadra M, Bhadra U. Drosophila oncogene Gas41 is an RNA interference modulator that intersects heterochromatin and the small interfering RNA pathway. FEBS J. 2015;282:153-73 pubmed publisher
    ..of RNA interference (RNAi) machinery in the nuclei, although three basic structural domains of RNAi components PAZ, PIWI and dsRNA with respect to binding are absent in the structural sequences...
  18. Ghartey Kwansah G, Li Z, Feng R, Wang L, Zhou X, Chen F, et al. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. BMC Dev Biol. 2018;18:7 pubmed publisher
    ..Meanwhile, Shutdown associates with transposons in the PIWI-interacting RNA pathway, playing a crucial role in both germ cells and ovarian somas...
  19. Newkirk S, Lee S, Grandi F, Gaysinskaya V, Rosser J, Vanden Berg N, et al. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017;114:E5635-E5644 pubmed publisher
    The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic defects...
  20. Luangpraseuth Prosper A, Lesueur E, Jouneau L, Pailhoux E, Cotinot C, Mandon Pépin B. TOPAZ1, a germ cell specific factor, is essential for male meiotic progression. Dev Biol. 2015;406:158-71 pubmed publisher
    ..The putative protein TOPAZ1 contains a PAZ domain, specifically found in PIWI, Argonaute and Zwille proteins...
  21. Phay M, Kim H, Yoo S. Analysis of piRNA-Like Small Non-coding RNAs Present in Axons of Adult Sensory Neurons. Mol Neurobiol. 2018;55:483-494 pubmed publisher
    ..b>PIWI-interacting RNAs (piRNAs), typically 25-34-nucleotide long, are originally identified and thought to be restricted ..
  22. Klastrup L, Bak S, Nielsen A. The influence of paternal diet on sncRNA-mediated epigenetic inheritance. Mol Genet Genomics. 2019;294:1-11 pubmed publisher
    ..Current research has identified alterations in the content of sncRNA subtypes, including microRNA (miRNA), Piwi-interacting RNA (piRNA), and transferRNA (tRNA)-derived small non-coding RNA (tsncRNA), in spermatozoa in response ..
  23. Meng X, Yang S, Zhang Y, Wang X, Goodfellow R, Jia Y, et al. Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs. J Biol Chem. 2015;290:11853-64 pubmed publisher
    ..The Piwi-interacting RNA (piRNA)-interacting protein Mili was expressed at high levels in testes from Mtdh knock-out mice...
  24. Mugat B, Akkouche A, Serrano V, Armenise C, Li B, Brun C, et al. MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells. PLoS Genet. 2015;11:e1005194 pubmed publisher
    ..via the microRNA pathway) to defense against molecular parasites (through the small interfering RNA and the Piwi-interacting RNA pathways)...
  25. Koziol U, Radio S, Smircich P, Zarowiecki M, Fernández C, Brehm K. A Novel Terminal-Repeat Retrotransposon in Miniature (TRIM) Is Massively Expressed in Echinococcus multilocularis Stem Cells. Genome Biol Evol. 2015;7:2136-53 pubmed publisher
    ..and Taenia solium) have very few mobile genetic elements (MGEs) in their genome, despite lacking a canonical PIWI pathway...
  26. Simon M, Sarkies P, Ikegami K, Doebley A, Goldstein L, Mitchell J, et al. Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants. Cell Rep. 2014;7:762-73 pubmed publisher
    Defects in the Piwi/piRNA pathway lead to transposon desilencing and immediate sterility in many organisms. We found that the C. elegans Piwi mutant prg-1 became sterile after growth for many generations...
  27. Shimizu Y, Tamai T, Goto S. Cell cycle regulator, small silencing RNA, and segmentation patterning gene expression in relation to embryonic diapause in the band-legged ground cricket. Insect Biochem Mol Biol. 2018;102:75-83 pubmed publisher
    ..regulator), caudal and pumilio (cad and pum; early segmentation genes) as well as P-element induced wimpy testis (piwi) (a small silencing RNA) prior to the onset of developmental arrest was notable...
  28. Tóth K, Pezic D, Stuwe E, Webster A. The piRNA Pathway Guards the Germline Genome Against Transposable Elements. Adv Exp Med Biol. 2016;886:51-77 pubmed publisher
    ..of the piRNA pathway is a ribonucleoprotein complex consisting of a small RNA, called piRNA, and a protein from the PIWI subfamily of Argonaute nucleases...
  29. Radion E, Morgunova V, Ryazansky S, Akulenko N, Lavrov S, Abramov Y, et al. Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline. Epigenetics Chromatin. 2018;11:40 pubmed publisher
    Telomeric small RNAs related to PIWI-interacting RNAs (piRNAs) have been described in various eukaryotes; however, their role in germline-specific telomere function remains poorly understood...
  30. Gaiti F, Calcino A, Tanurdzic M, Degnan B. Origin and evolution of the metazoan non-coding regulatory genome. Dev Biol. 2017;427:193-202 pubmed publisher
    ..analysis of non-bilaterian metazoan, unicellular holozoan and fungal genomes, the evolution of some ncRNAs, such as Piwi-interacting RNAs, correlates with the emergence of metazoan multicellularity, while others, including microRNAs, ..
  31. Wang H, Wang B, Liu X, Liu Y, Du X, Zhang Q, et al. Identification and expression of piwil2 in turbot Scophthalmus maximus, with implications of the involvement in embryonic and gonadal development. Comp Biochem Physiol B Biochem Mol Biol. 2017;208-209:84-93 pubmed publisher
    Piwil2, a member of the Argonaute family, is involved in the biogenesis of PIWI-interacting RNAs (piRNAs) and plays an important role in regulating gametogenesis...
  32. Lu L, Katsaros D, Risch H, Canuto E, Biglia N, Yu H. MicroRNA let-7a modifies the effect of self-renewal gene HIWI on patient survival of epithelial ovarian cancer. Mol Carcinog. 2016;55:357-65 pubmed publisher
    Aberrant expressions of self-renewal gene HIWI and microRNA (miRNA) let-7a are observed in epithelial ovarian cancer (EOC)...
  33. Lo P, Huang Y, Poulton J, Leake N, Palmer W, Vera D, et al. RNA helicase Belle/DDX3 regulates transgene expression in Drosophila. Dev Biol. 2016;412:57-70 pubmed publisher
    ..the RNA helicase Spindle-E (Spn-E), a nuage RNA helicase that plays a crucial role in regulating RNA processing and PIWI-interacting RNA (piRNA) biogenesis in germline cells, is required for loss-of-bel-induced transgene silencing...
  34. Karami Madani G, Rad A, Molavi M, Ardalan Khales S, Abbaszadegan M, Forghanifard M. Predicting the Correlation of EZH2 and Cancer Stem Cell Markers in Esophageal Squamous Cell Carcinoma. J Gastrointest Cancer. 2018;49:437-441 pubmed publisher
    ..Inhibition of EZH2 expression in KYSE30 cells caused significant changes in different genes. Indeed, HIWI and HEY1 genes were over- and underexpressed in KYSE30 cells, respectively, following EZH2 silencing...
  35. Liu K, Chen C, Guo Y, Lam R, Bian C, Xu C, et al. Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci U S A. 2010;107:18398-403 pubmed publisher
    ..the ancestral staphylococcal nuclease domain-containing 1 (SND1) polypeptide is expressed and associates with PIWIL1/Miwi in germ cells...
  36. Weiss K, Antoniou A, Schratt G. Non-coding mechanisms of local mRNA translation in neuronal dendrites. Eur J Cell Biol. 2015;94:363-7 pubmed publisher
    ..point towards a widespread involvement of ncRNA families in local translation, including less abundant small RNAs (PIWI-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs)) and long ncRNAs (circular RNAs (..
  37. Yoshimura T, Watanabe T, Kuramochi Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, et al. Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. EMBO Rep. 2018;19: pubmed publisher
    ..is a piRNA-guided retrotransposon silencing system which includes processing of retrotransposon transcripts by PIWI-piRNAs in secondary piRNA biogenesis...
  38. Reeves M, Firek M, Chen S, Amaar Y. Evidence that RASSF1C stimulation of lung cancer cell proliferation depends on IGFBP-5 and PIWIL1 expression levels. PLoS ONE. 2014;9:e101679 pubmed publisher
    ..In previous work, we demonstrated that RASSF1C up-regulates piwil1 gene expression, which is a stem cell self-renewal gene that is over-expressed in several human cancers, including ..
  39. Marinov G, Wang J, Handler D, Wold B, Weng Z, Hannon G, et al. Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified. Dev Cell. 2015;32:765-71 pubmed publisher
    ..reported that chromatin immunoprecipitation sequencing (ChIP-seq) reveals the genome-wide sites of occupancy by Piwi, a piRNA-guided Argonaute protein central to transposon silencing in Drosophila...
  40. Ku H, Gangaraju V, Qi H, Liu N, Lin H. Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila. PLoS Genet. 2016;12:e1005813 pubmed publisher
    b>Piwi proteins associate with piRNAs and functions in epigenetic programming, post-transcriptional regulation, transposon silencing, and germline development...
  41. Zhou R, Ma G, Korhonen P, Luo Y, Zhu H, Luo Y, et al. Comparative transcriptomic analyses of male and female adult Toxocara canis. Gene. 2017;600:85-89 pubmed publisher
    ..In addition, small RNA pathways involved in reproduction were characterized, but there was no evidence for piwi RNA pathways in adult T. canis...
  42. Radion E, Ryazansky S, Akulenko N, Rozovsky Y, Kwon D, Morgunova V, et al. Telomeric Retrotransposon HeT-A Contains a Bidirectional Promoter that Initiates Divergent Transcription of piRNA Precursors in Drosophila Germline. J Mol Biol. 2017;429:3280-3289 pubmed publisher
    b>PIWI-interacting RNAs (piRNAs) provide the silencing of transposable elements in the germline. Drosophila telomeres are maintained by transpositions of specialized telomeric retroelements...
  43. Krishnan A, Korrapati A, Zou A, Qu Y, Wang X, Califano J, et al. Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma. Oral Oncol. 2017;65:68-75 pubmed publisher
    ..associated with tumor stage, NONHSAT067200 with patient survival, and NONHSAT081250 with smoking-altered PIWIL1 protein expression...
  44. Ren X, Yang Z, Mao D, Chang Z, Qiao H, Wang X, et al. Performance of the Cas9 nickase system in Drosophila melanogaster. G3 (Bethesda). 2014;4:1955-62 pubmed publisher
    ..Finally, a defined piwi mutant allele is generated with this system through homology-directed repair...
  45. Chang G, Chen R, Xu L, Ma T, Wang H, Chen J, et al. DNA methylation and NF-Y regulate Piwil1 expression during chicken spermatogenesis. Anim Reprod Sci. 2015;162:95-103 pubmed publisher
    ..To reveal the transcriptional regulatory mechanisms of Piwil1 in chickens, we cloned sequences of the chicken Piwil1 promoter region and performed luciferase reporter and ..
  46. Rahman R, Chirn G, Kanodia A, Sytnikova Y, Brembs B, Bergman C, et al. Unique transposon landscapes are pervasive across Drosophila melanogaster genomes. Nucleic Acids Res. 2015;43:10655-72 pubmed publisher
    ..Finally, we show novel transposon insertions negatively correlate with Piwi-interacting RNA (piRNA) levels for most transposon families, except for the highly-abundant roo retrotransposon...
  47. Czech B, Hannon G. One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing. Trends Biochem Sci. 2016;41:324-337 pubmed publisher
    The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects the genetic information of animal germ cells from the deleterious effects of molecular parasites, such as transposons...
  48. Takemoto N, Yoshimura T, Miyazaki S, Tashiro F, Miyazaki J. Gtsf1l and Gtsf2 Are Specifically Expressed in Gonocytes and Spermatids but Are Not Essential for Spermatogenesis. PLoS ONE. 2016;11:e0150390 pubmed publisher
    ..Pull-down experiments showed that both GTSF1L and GTSF2 can interact with PIWI-protein complexes...
  49. Tang W, Seth M, Tu S, Shen E, Li Q, Shirayama M, et al. A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans. Dev Cell. 2018;44:762-770.e3 pubmed publisher
    In metazoans, Piwi-related Argonaute proteins engage piRNAs (Piwi-interacting small RNAs) to defend the genome against invasive nucleic acids, such as transposable elements...
  50. Sharma N, Singh S. Implications of non-coding RNAs in viral infections. Rev Med Virol. 2016;26:356-68 pubmed publisher
    ..These include transfer RNAs, ribosomal RNAs, microRNA (miRNA), short interfering RNA, long non-coding RNA, piwi-interacting RNA and small nuclear RNA...
  51. Allen S, Hug I, Pabian S, Rzeszutek I, Hoehener C, Nowacki M. Circular Concatemers of Ultra-Short DNA Segments Produce Regulatory RNAs. Cell. 2017;168:990-999.e7 pubmed publisher
    In the ciliated protozoan Paramecium tetraurelia, Piwi-associated small RNAs are generated upon the elimination of tens of thousands of short transposon-derived DNA segments as part of development...
  52. Akkouche A, Mugat B, Barckmann B, Varela Chavez C, Li B, Raffel R, et al. Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult Ovaries. Mol Cell. 2017;66:411-419.e4 pubmed publisher
    ..Here, we show that transient Piwi depletion in Drosophila embryos results in H3K9me3 decrease at piRNA clusters in ovaries...
  53. Dehghani M, Lasko P. Multiple Functions of the DEAD-Box Helicase Vasa in Drosophila Oogenesis. Results Probl Cell Differ. 2017;63:127-147 pubmed publisher
    ..We review literature that implicates Vas in Piwi-interacting RNA (piRNA) biogenesis in germline cells and in regulating mitosis in germline stem cells (GSCs)...
  54. Han Y, Li Y, Xia S, Zhang Y, Zheng J, Li W. PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer. Cell Physiol Biochem. 2017;44:1-20 pubmed publisher
    P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins...
  55. Venkatesh T, Suresh P, Tsutsumi R. Non-coding RNAs: Functions and applications in endocrine-related cancer. Mol Cell Endocrinol. 2015;416:88-96 pubmed publisher
    ..we aimed to summarize the roles and clinical implications of recently discovered ncRNAs, including long ncRNAs, PIWI-interacting RNAs, tRNA- and Y RNA-derived ncRNAs, and small nucleolar RNAs, in endocrine-related cancers affecting ..
  56. Lim R, Kai T. A piece of the pi(e): The diverse roles of animal piRNAs and their PIWI partners. Semin Cell Dev Biol. 2015;47-48:17-31 pubmed publisher
    Small non-coding RNAs are indispensable to many biological processes. A class of endogenous small RNAs, termed PIWI-interacting RNAs (piRNAs) because of their association with PIWI proteins, has known roles in safeguarding the genome ..
  57. Cai X, Yu S, Mipam T, Yang F, Zhao W, Liu W, et al. Comparative analysis of testis transcriptomes associated with male infertility in cattleyak. Theriogenology. 2017;88:28-42 pubmed publisher
    ..However, downregulated SPP1, SPIN2B, and PIWIL1 were associated with cell cycle progression and spermatogonial genome integrity, whereas CDKN2C, CYP26A1, OVOL1, ..
  58. Triska J, Vrchotova N, Balík J, Soural I, Sotolář R. Variability in the Content of Trans-Resveratrol, Trans-ε-Viniferin and R2-Viniferin in Grape Cane of Seven Vitis vinifera L. Varieties during a Three-Year Study. Molecules. 2017;22: pubmed publisher
    ..The study included three blue grape varieties of Vitis vinifera L. (Cabernet Moravia, Blaufränkisch, and Piwi variety Laurot) and four white grape varieties (Chardonnay, Green Veltliner, Piwi variety Hibernal, and Piwi ..
  59. Ninova M, Griffiths Jones S, Ronshaugen M. Abundant expression of somatic transposon-derived piRNAs throughout Tribolium castaneum embryogenesis. Genome Biol. 2017;18:184 pubmed publisher
    b>Piwi-interacting RNAs (piRNAs) are a class of short (~26-31-nucleotide) non-protein-coding RNAs expressed in the metazoan germline...
  60. Navarro A, Tejero R, Viñolas N, Cordeiro A, Marrades R, Fuster D, et al. The significance of PIWI family expression in human lung embryogenesis and non-small cell lung cancer. Oncotarget. 2015;6:31544-56 pubmed publisher
    ..The mRNA expression analysis showed that PIWIL1 was highly expressed in 7-week embryos and downregulated during the subsequent weeks of development...
  61. Zhang C, Robinson B, Xu W, Yang L, Yao B, Zhao H, et al. The ecdysone receptor coactivator Taiman links Yorkie to transcriptional control of germline stem cell factors in somatic tissue. Dev Cell. 2015;34:168-80 pubmed publisher
    ..distinct pro-growth program of Yki-induced/Tai-dependent genes, including the germline stem cell factors nanos and piwi. These data reveal Hippo/Ec pathway crosstalk in the form a Yki-Tai complex that collaboratively induces germline ..
  62. Wang Y, Liu J, Wu G, Yang F. Manipulations in HIWI level exerts influence on the proliferation of human non-small cell lung cancer cells. Exp Ther Med. 2016;11:1971-1976 pubmed
    ..b>HIWI is a member of the human piwi family, members of which are known for their roles in RNA silencing...
  63. Akulenko N, Ryazansky S, Morgunova V, Komarov P, Olovnikov I, Vaury C, et al. Transcriptional and chromatin changes accompanying de novo formation of transgenic piRNA clusters. RNA. 2018;: pubmed publisher
    Expression of transposable elements in the germline is controlled by Piwi-interacting (pi) RNAs produced by genomic loci termed piRNA clusters and associated with Rhino, a Heterochromatin Protein 1 (HP1) homolog...
  64. Shen S, Yu H, Liu X, Liu Y, Zheng J, Wang P, et al. PIWIL1/piRNA-DQ593109 Regulates the Permeability of the Blood-Tumor Barrier via the MEG3/miR-330-5p/RUNX3 Axis. Mol Ther Nucleic Acids. 2018;10:412-425 pubmed publisher
    ..In the present study, we demonstrated that the PIWIL1/piRNA-DQ593109 (piR-DQ593109) complex was the predominant regulator of BTB permeability...
  65. Chinen M, Lei E. Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway. Biochem Biophys Res Commun. 2017;483:951-957 pubmed publisher
    ..We found that mutation of T1149 or R1158 in the conserved PIWI domain causes AGO2 protein instability, but only T1149 affects RNAi activity...
  66. Pritykin Y, Brito T, Schupbach T, Singh M, Pane A. Integrative analysis unveils new functions for the Drosophila Cutoff protein in noncoding RNA biogenesis and gene regulation. RNA. 2017;23:1097-1109 pubmed publisher
    b>Piwi-interacting RNAs (piRNAs) are central components of the piRNA pathway, which directs transposon silencing and guarantees genome integrity in the germ cells of several metazoans...
  67. Sun R, Gao C, Li D, Li B, Ding Y. Expression Status of PIWIL1 as a Prognostic Marker of Colorectal Cancer. Dis Markers. 2017;2017:1204937 pubmed publisher
    The PIWI-like protein 1 (PIWIL1) plays a crucial role in stem cell proliferation, embryogenesis, growth, and development, as well as differentiation and maturation in multiple organisms...
  68. Lewis S, Quarles K, Yang Y, Tanguy M, Frezal L, Smith S, et al. Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements. Nat Ecol Evol. 2018;2:174-181 pubmed publisher
    In animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence transposable elements (TEs), protecting the germline from genomic instability and mutation...
  69. Teixeira F, Okuniewska M, Malone C, Coux R, Rio D, Lehmann R. piRNA-mediated regulation of transposon alternative splicing in the soma and germ line. Nature. 2017;: pubmed publisher
    ..The Piwi-interacting small RNA (piRNA) pathway is vital for the regulation of transposable elements, by inducing ..
  70. Quénerch du E, Anand A, Kai T. The piRNA pathway is developmentally regulated during spermatogenesis in Drosophila. RNA. 2016;22:1044-54 pubmed publisher
    b>PIWI-interacting RNAs (piRNAs) are predominantly produced in animal gonads to suppress transposons during germline development...
  71. Petit M, Mongelli V, Frangeul L, Blanc H, Jiggins F, Saleh M. piRNA pathway is not required for antiviral defense in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2016;113:E4218-27 pubmed publisher
    ..In insects, the small interfering RNA (siRNA) pathway is the major antiviral response. In recent years, the Piwi-interacting RNA (piRNA) pathway also has been implicated in antiviral defense in mosquitoes infected with ..
  72. Zhang L, Zhang H, Zhang H, Benson M, Han X, Li D. Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Food Chem Toxicol. 2017;105:177-185 pubmed publisher
    ..The body weight, testis index, and histomorphology change were observed and the global changes of piwi-interacting RNA (piRNA) expression were evaluated...
  73. Varjak M, Donald C, Mottram T, Sreenu V, Merits A, Maringer K, et al. Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Negl Trop Dis. 2017;11:e0006010 pubmed publisher
    ..Two different RNAi pathways are involved in antiviral responses: the PIWI-interacting RNA (piRNA) and exogenous short interfering RNA (exo-siRNA) pathways, which are characterized by the ..
  74. Lee Y, Moon S, Park M, Jung W, Park Y, Song S, et al. Multiplex bioimaging of piRNA molecular pathway-regulated theragnostic effects in a single breast cancer cell using a piRNA molecular beacon. Biomaterials. 2016;101:143-55 pubmed publisher
    Recently, PIWI-interacting small non-coding RNAs (piRNAs) have emerged as novel cancer biomarkers candidate because of their high expression level in various cancer types and role in the control of tumor suppressor genes...
  75. Gou L, Kang J, Dai P, Wang X, Li F, Zhao S, et al. Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017;169:1090-1104.e13 pubmed publisher
    Genetic studies have elucidated critical roles of Piwi proteins in germline development in animals, but whether Piwi is an actual disease gene in human infertility remains unknown...
  76. Litwin M, Dubis J, Arczyńska K, Piotrowska A, Frydlewicz A, Karczewski M, et al. Correlation of HIWI and HILI Expression with Cancer Stem Cell Markers in Colorectal Cancer. Anticancer Res. 2015;35:3317-24 pubmed
    ..Recently, aberrant expression of P-element induced wimpy testis proteins-PIWI (HIWI and HILI) has been identified in various types of tumors...
  77. Panero R, Rinaldi A, Memoli D, Nassa G, Ravo M, Rizzo F, et al. iSmaRT: a toolkit for a comprehensive analysis of small RNA-Seq data. Bioinformatics. 2017;33:938-940 pubmed publisher
    ..and tools are available to study microRNAs (miRNAs), only few focus on novel classes of sncRNAs, in particular PIWI-interacting RNAs (piRNAs)...
  78. Sun Y, Xie L, Zhuo X, Chen Q, Ghoneim D, Zhang B, et al. Domestic chickens activate a piRNA defense against avian leukosis virus. elife. 2017;6: pubmed publisher
    b>PIWI-interacting RNAs (piRNAs) protect the germ line by targeting transposable elements (TEs) through the base-pair complementarity. We do not know how piRNAs co-evolve with TEs in chickens...
  79. Laricchia K, Zdraljevic S, Cook D, Andersen E. Natural Variation in the Distribution and Abundance of Transposable Elements Across the Caenorhabditis elegans Species. Mol Biol Evol. 2017;34:2187-2202 pubmed publisher
    ..rare variant correlations to reveal several candidate genes that impact TE regulation, including small regulatory piwi-interacting RNAs and chromatin factors...
  80. Zhang L, Meng X, Xiang Z, Li D, Han X. Roles of mmu_piR_003399 in microcystin-leucine arginine (MC-LR)-induced reproductive toxicity in the spermatogonial cells and testis. Toxicol Sci. 2017;: pubmed publisher
    ..The present study was designed to investigate the functions of P-element-induced wimpy (piwi)-interacting RNAs (piRNAs) in MC-LR-induced reproductive toxicity in male mice...
  81. Leopold L, Heestand B, Seong S, Shtessel L, Ahmed S. Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015;112:E2667-76 pubmed publisher
    ..RNAe is promoted by the Piwi Argonaute protein PRG-1 and associated Piwi-interacting RNAs (piRNAs), as well as by proteins that promote and ..
  82. Cao J, Xu G, Lan J, Huang Q, Tang Z, Tian L. High expression of piwi-like RNA-mediated gene silencing 1 is associated with poor prognosis via regulating transforming growth factor-β receptors and cyclin-dependent kinases in breast cancer. Mol Med Rep. 2016;13:2829-35 pubmed publisher
    Previous studies have demonstrated that abnormal expression levels of PIWI may serve a crucial role in tumorigenesis. However, the pathological role and its association with prognosis remains to be fully elucidated...
  83. Pridöhl F, Weißkopf M, Koniszewski N, Sulzmaier A, Uebe S, Ekici A, et al. Transcriptome sequencing reveals maelstrom as a novel target gene of the terminal system in the red flour beetle Tribolium castaneum. Development. 2017;144:1339-1349 pubmed publisher
    ..Among others, we found the PIWI-interacting RNA factor Maelstrom to be crucial for early embryonic polarization...
  84. Inoue K, Ichiyanagi K, Fukuda K, Glinka M, Sasaki H. Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. PLoS Genet. 2017;13:e1006926 pubmed publisher
    ..In mouse prospermatogonia, PIWI-interacting small RNAs (piRNAs) combat retrotransposon activity to maintain the genomic integrity...
  85. Patil A, Tatsuke T, Mon H, Lee J, Morokuma D, Hino M, et al. Molecular characterization of mitochondrial Zucchini and its relation to nuage-piRNA pathway components in Bombyx mori ovary-derived BmN4 cells. Biochem Biophys Res Commun. 2017;493:971-978 pubmed publisher
    b>Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with PIWI subfamily proteins, which play an important role in transposon silencing in animal germ cell...
  86. Pal Bhadra M, Bhadra U, Birchler J. RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell. 2002;9:315-27 pubmed
    ..Mutations in piwi, which belongs to a gene family with members required for RNAi, block PTGS and one aspect of TGS, indicating a ..
  87. Zeng Y, Qu L, Meng L, Liu C, Dong B, Xing X, et al. HIWI expression profile in cancer cells and its prognostic value for patients with colorectal cancer. Chin Med J (Engl). 2011;124:2144-9 pubmed
    HIWI is a member of PIWI gene family and its expression is found in various tumors, indicating that it may play a pivotal role in tumor development...
  88. Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, et al. The genetic basis of natural variation in a phoretic behavior. Nat Commun. 2017;8:273 pubmed publisher
    ..The nict-1 locus contains a Piwi-interacting small RNA (piRNA) cluster; we observe that the Piwi Argonaute PRG-1 is involved in the regulation of ..
  89. Alexiou P, Maragkakis M, Mourelatos Z, Vourekas A. cCLIP-Seq: Retrieval of Chimeric Reads from HITS-CLIP (CLIP-Seq) Libraries. Methods Mol Biol. 2018;1680:87-100 pubmed publisher
    ..We recently reported an analysis of chimeric reads from the Drosophila Piwi protein Aubergine, which revealed a novel mechanism for mRNA entrapment within germ RNP granules...
  90. Fefelova E, Stolyarenko A, Yakushev E, Gvozdev V, Klenov M. [Participation of the piRNA pathway in recruiting a component of RNA polymerase I transcription initiation complex to germline cell nucleoli]. Mol Biol (Mosk). 2017;51:824-830 pubmed publisher
    Proteins of the Piwi family and short Piwi-interacting RNAs (piRNAs) ensure the protection of the genome from transposable elements...
  91. Xie K, Zhang K, Kong J, Wang C, Gu Y, Liang C, et al. Cancer-testis gene PIWIL1 promotes cell proliferation, migration, and invasion in lung adenocarcinoma. Cancer Med. 2017;: pubmed publisher
    Piwi-like RNA-mediated gene silencing 1 (PIWIL1) has been identified as a novel extremely highly expressed cancer-testis (CT) gene in lung adenocarcinoma...
  92. Rodríguez Malavé N, Rao D. Long noncoding RNAs in hematopoietic malignancies. Brief Funct Genomics. 2016;15:227-38 pubmed publisher
    ..Many of these RNAs are regulatory in nature with functions in gene expression regulation such as piwi-interacting RNAs, small interfering RNAs and micro RNAs...