PITPNM1

Summary

Gene Symbol: PITPNM1
Description: phosphatidylinositol transfer protein membrane associated 1
Alias: DRES9, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9, membrane-associated phosphatidylinositol transfer protein 1, NIR-2, PITPnm 1, PYK2 N-terminal domain-interacting receptor 2, drosophila retinal degeneration B homolog, retinal degeneration B alpha 1
Species: human
Products:     PITPNM1

Top Publications

  1. Song C, Conlon T, Deng W, Coleman K, Zhu P, Plummer C, et al. Toxicology and Pharmacology of an AAV Vector Expressing Codon-optimized RPGR in RPGR-deficient Rd9 Mice. Hum Gene Ther Clin Dev. 2018;: pubmed publisher
    ..and potency study of this vector administered by subretinal injection in the naturally occurring RPGR-deficient Rd9 mouse model...
  2. Zhao C, Wu A, Yu X, Gu Y, Lu Y, Song X, et al. Microdomain elements of airway smooth muscle in calcium regulation and cell proliferation. J Physiol Pharmacol. 2018;69: pubmed publisher
    ..strengthening of the ER/SR-PM connection by E-Syt1 facilitates the phosphatidylinositol (PI) transfer protein, Nir2, to supplement PI, a PI(4,5)P2 substrate, for the generation of IP3 and the propagation of Ca<..
  3. Anbazhagan K, Bhatnagar Mathur P, Vadez V, Dumbala S, Kishor P, Sharma K. DREB1A overexpression in transgenic chickpea alters key traits influencing plant water budget across water regimes. Plant Cell Rep. 2015;34:199-210 pubmed publisher
    ..events of chickpea developed by Agrobacterium-mediated genetic transformation, four single copy events (RD2, RD7, RD9 and RD10) were characterized for DREB1A gene overexpression and evaluated under water stress in a biosafety ..
  4. Ghosh D, Bagley A, Na Y, Birrer M, Bhatia S, Belcher A. Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. Proc Natl Acad Sci U S A. 2014;111:13948-53 pubmed publisher
    ..Second-window near-infrared light (NIR2, 950-1,400 nm) is promising for in vivo fluorescence imaging due to deep tissue penetration and low tissue ..
  5. Costa P, Amaro A, Ferreira A, Machado D, Albuquerque T, Couto I, et al. Rapid identification of veterinary-relevant Mycobacterium tuberculosis complex species using 16S rDNA, IS6110 and Regions of Difference-targeted dual-labelled hydrolysis probes. J Microbiol Methods. 2014;107:13-22 pubmed publisher
    ..is identified, the second amplification step allows the assessment of the presence or absence of the RD1, RD4 and RD9 genomic regions. The correspondent pattern allows us to infer the species of the isolate as M...
  6. Lewis M, Quint E, Glazier A, Fuchs H, de Angelis M, Langford C, et al. An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet. 2009;41:614-8 pubmed publisher
    ..96 transcripts with significantly altered expression in homozygotes; notably, Slc26a5, Ocm, Gfi1, Ptprq and Pitpnm1 were downregulated. Hypergeometric P-value analysis showed that hundreds of genes were upregulated in mutants...
  7. Mobini G, Ghafari A, Amanpour S, Fateh R, Ghahremani M, Muhammadnejad S, et al. In vivo identification of novel TGIF2LX target genes in colorectal adenocarcinoma using the cDNA-AFLP method. Arab J Gastroenterol. 2018;19:65-70 pubmed publisher
    ..the identified genes indicated that the N-terminal domain-interacting receptor 1 (Nir1) gene was suppressed whereas Nir2 and fragile histidine triad (FHIT) genes were upregulated followed by the overexpression of TGIF2LX gene...
  8. Kim Y, Guzmán Hernández M, Wisniewski E, Balla T. Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence. Dev Cell. 2015;33:549-61 pubmed publisher
    ..Here, we show that the Drosophila RdgB homolog, Nir2, a presumed PtdIns transfer protein, not only transfers PtdIns from the ER to the PM but also ..
  9. Carlisle F, Pearson S, Steel K, Lewis M. Pitpnm1 is expressed in hair cells during development but is not required for hearing. Neuroscience. 2013;248:620-5 pubmed publisher
    ..Here we describe the expression of Pitpnm1 in the inner ear...

More Information

Publications49

  1. Tan K, Zhang J, Teng X, Liang J, Wang X, Yuan X, et al. High level of IFN-γ released from whole blood of human tuberculosis infections following stimulation with Rv2073c of Mycobacterium tuberculosis. J Microbiol Methods. 2015;114:57-61 pubmed publisher
    ..The region of difference 9 (RD9) presents the genome of the causative pathogen Mycobacterium tuberculosis rather than other species of the genus ..
  2. Mirzaki S, Mosavari N, Nazari R, Akbarian M. Molecular identification of Mycobacterium tuberculosis complex by region of differentiation-typing and polymerase chain reaction-restriction fragment length polymorphism method. Int J Mycobacteriol. 2016;5 Suppl 1:S190 pubmed publisher
    ..method and subjected to polymerase chain reaction (PCR)-16SrRNA, PCR-IS6110, and RD-typing with primers RD1, RD4, RD9, and RD12, respectively...
  3. Mobini G, Ghahremani M, Amanpour S, Dehpour A, Akbari A, Hoseiniharouni S, et al. Transforming Growth Factor Beta-Induced Factor 2-Linked X (TGIF2LX) Regulates Two Morphogenesis Genes, Nir1 and Nir2 in Human Colorectal. Acta Med Iran. 2016;54:302-7 pubmed
    ..The results revealed a significant down-regulation and up-regulationby TGIF2LX of Nir1 and Nir2 genes, respectively. The genes are engaged in the cell morphogenesis process...
  4. Hlokwe T, Said H, Gcebe N. Mycobacterium tuberculosis infection in cattle from the Eastern Cape Province of South Africa. BMC Vet Res. 2017;13:299 pubmed publisher
    ..tuberculosis, as confirmed by polymerase chain reaction (PCR) using primers targeting 3 regions of difference (RD4, RD9 and RD12) on the genomes, was isolated from cattle originating from two epidemiologically unrelated farms in the ..
  5. Chae H, Han S, Kim S, Ki C, Huh H, Yong D, et al. Development of a One-Step Multiplex PCR Assay for Differential Detection of Major Mycobacterium Species. J Clin Microbiol. 2017;55:2736-2751 pubmed publisher
    ..tuberculosis (M. tuberculosis) from MTBC using RD9, (iii) selectively identify the widespread M...
  6. Mathewos B, Kebede N, Kassa T, Mihret A, Getahun M. Characterization of mycobacterium isolates from pulmomary tuberculosis suspected cases visiting Tuberculosis Reference Laboratory at Ethiopian Health and Nutrition Research Institute, Addis Ababa Ethiopia: a cross sectional study. Asian Pac J Trop Med. 2015;8:35-40 pubmed publisher
    ..From these 110 MTBC isolates, 81 of them were randomly taken and run by the deletion typing RD9 PCR method of molecular technique. Out of these 78 (96...
  7. Chang C, Liou J. Homeostatic regulation of the PI(4,5)P2-Ca(2+) signaling system at ER-PM junctions. Biochim Biophys Acta. 2016;1861:862-873 pubmed publisher
    ..signaling, including the ER Ca(2+) sensor STIM1, the extended synaptotagmin E-Syt1, and the PI transfer protein Nir2. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K...
  8. Yadav S, Garner K, Georgiev P, Li M, Gomez Espinosa E, Panda A, et al. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. J Cell Sci. 2015;128:3330-44 pubmed publisher
    ..b>RDGBα (hereafter RDGB) is a multi-domain protein with a PtdIns transfer protein (PITP) domain (RDGB-PITPd)...
  9. Fischer M, McClements M, Martinez Fernandez de la Camara C, Bellingrath J, Dauletbekov D, Ramsden S, et al. Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa. Mol Ther. 2017;25:1854-1865 pubmed publisher
    ..RPGR rescues the disease phenotype in two relevant animal models (Rpgr-/y and C57BL/6JRd9/Boc) and shows good safety in C57BL6/J wild-type mice...
  10. Hardie R, Liu C, Randall A, Sengupta S. In vivo tracking of phosphoinositides in Drosophila photoreceptors. J Cell Sci. 2015;128:4328-40 pubmed publisher
    ..t½ ∼40 s), but both were greatly slowed in mutants of DAG kinase (rdgA) or PtdIns transfer protein (rdgB)...
  11. Alemayehu M, Gelaw B, Abate E, Wassie L, Belyhun Y, Bekele S, et al. Active tuberculosis case finding and detection of drug resistance among HIV-infected patients: A cross-sectional study in a TB endemic area, Gondar, Northwest Ethiopia. Int J Mycobacteriol. 2014;3:132-8 pubmed publisher
    ..A PCR-based RD9 deletion and genus typing, as well as first-line anti-TB drug susceptibility testing, was performed for all culture-..
  12. Kim Y, Guzmán Hernández M, Wisniewski E, Echeverría N, Balla T. Phosphatidylinositol and phosphatidic acid transport between the ER and plasma membrane during PLC activation requires the Nir2 protein. Biochem Soc Trans. 2016;44:197-201 pubmed publisher
    ..Recent studies identified the large PITP protein, Nir2 as important for PtdIns transfer from the ER to the PM...
  13. Cockcroft S, Garner K, Yadav S, Gomez Espinoza E, Raghu P. RdgBα reciprocally transfers PA and PI at ER-PM contact sites to maintain PI(4,5)P2 homoeostasis during phospholipase C signalling in Drosophila photoreceptors. Biochem Soc Trans. 2016;44:286-92 pubmed publisher
    ..The class II PITP, retinal degeneration type B (RdgB)α is a multi-domain protein and its PITP domain can bind and transfer PI and PA...
  14. Alizadeh K, Mosavari N, Nazari R. Restriction fragment length polymorphism pattern of Mycobacterium isolates from rodents in infected cattle farms. Int J Mycobacteriol. 2016;5 Suppl 1:S191-S192 pubmed publisher
    ..showed the presence of Mycobacterium and these were subjected to PCR-16SrRNA, PCR-IS6110, and RD Typing (RD1, RD4, RD9, and RD12) methods...
  15. Adane K, Ameni G, Bekele S, Abebe M, Aseffa A. Prevalence and drug resistance profile of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients attending two public hospitals in East Gojjam zone, northwest Ethiopia. BMC Public Health. 2015;15:572 pubmed publisher
    ..A cross-sectional study was conducted between May 2011 and January 2012 using Region of difference-9 (RD9) typing for the identification of species mycobacterium. Drug susceptibility testing (DST) of M...
  16. Moghaddam R, Mosavari N, Mahalati A. Molecular identification of Mycobacterium tuberculosis complex isolates from Kermanshah Province, Iran. Int J Mycobacteriol. 2016;5 Suppl 1:S203 pubmed publisher
    ..Furthermore, 146bp, 172bp, 235bp, and 369bp at RD1, RD4, RD9, and RD12, respectively, were observed during RD typing...
  17. Herrera León L, Pozuelo Díaz R, Molina Moreno T, Valverde Cobacho A, Saiz Vega P, Jiménez Pajares M. [Differentiation of species within the Mycobacterium tuberculosis complex by molecular techniques]. Enferm Infecc Microbiol Clin. 2009;27:496-502 pubmed publisher
    ..and 2) multiplex-PCR to determine the presence/absence of the RD9 and RD1 regions. The results showed 100% agreement between phenotype study and the molecular scheme...
  18. Getahun M, Ameni G, Kebede A, Yaregal Z, Hailu E, Medihn G, et al. Molecular typing and drug sensitivity testing of Mycobacterium tuberculosis isolated by a community-based survey in Ethiopia. BMC Public Health. 2015;15:751 pubmed publisher
    ..All 92 isolates were confirmed as M. tuberculosis by RD9-based PCR and spoligotyping of 91 of these isolates leds to the identification of 41 spoligotype patterns...
  19. Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, et al. A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms. Genes Funct. 1997;1:205-13 pubmed
    ..We have isolated a human gene, DRES9, and its murine homologue (Dres9), which show a high degree of similarity to the Drosophila rdgB gene...
  20. Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S. Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Nat Cell Biol. 2005;7:225-34 pubmed
    ..Here, we show that Nir2, a peripheral Golgi protein containing a PI-transfer domain, is essential for maintaining the structural and ..
  21. Aikawa Y, Hara H, Watanabe T. Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene. Biochem Biophys Res Commun. 1997;236:559-64 pubmed
    Null mutations in the retinal degeneration B gene (rdgB) in flies result in an activity-dependent retinal degeneration...
  22. Burgis N, Cunningham R. Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. J Biol Chem. 2007;282:3531-8 pubmed
    ..We hypothesized that the RdgB protein is active on 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) as well as deoxyinosine triphosphate...
  23. Chang C, Liou J. Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions. J Biol Chem. 2015;290:14289-301 pubmed publisher
    ..The PI transfer protein Nir2 is essential for replenishing PM PIP2 following receptor-induced hydrolysis, but key mechanistic aspects of this ..
  24. Litvak V, Tian D, Carmon S, Lev S. Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. Mol Cell Biol. 2002;22:5064-75 pubmed
    ..In this study we provide evidence that the protein Nir2 is essential for cytokinesis...
  25. Amarilio R, Ramachandran S, Sabanay H, Lev S. Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction. J Biol Chem. 2005;280:5934-44 pubmed
    ..that the integral ER-membrane protein VAP-B causes a striking rearrangement of the ER through interaction with the Nir2 and Nir3 proteins...
  26. Ocaka L, Spalluto C, Wilson D, Hunt D, Halford S. Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3. Cytogenet Genome Res. 2005;108:293-302 pubmed
    ..Three mammalian phosphatidylinositol transfer protein membrane-associated genes (PITPNM1, 2 and 3) with homology to Drosophila rdgB have previously been described and shown to be expressed in the ..
  27. Tian D, Litvak V, Toledo Rodriguez M, Carmon S, Lev S. Nir2, a novel regulator of cell morphogenesis. Mol Cell Biol. 2002;22:2650-62 pubmed
    ..Here we show that Nir2, a novel protein related to Drosophila retinal degeneration B (RdgB), markedly affects cell morphology through a novel Rho-inhibitory domain (Rid) which resides in its N-terminal ..
  28. Yahyaoui Azami H, Aboukhassib H, Bouslikhane M, Berrada J, Rami S, Reinhard M, et al. Molecular characterization of bovine tuberculosis strains in two slaughterhouses in Morocco. BMC Vet Res. 2017;13:272 pubmed publisher
    ..of the AF positive samples were confirmed as tuberculous mycobacteria (n = 147), 99% of these (n = 146) having RD9 and among the latter, 98% (n = 143) positive while 2% (n = 3) negative for RD4 A total of 134 samples were ..
  29. Hsieh T, Chen Y, Chang C, Lee W, Liou J. Cortical actin contributes to spatial organization of ER-PM junctions. Mol Biol Cell. 2017;28:3171-3180 pubmed publisher
    ..that intact F-actin architecture is required for phosphatidylinositol 4,5-bisphosphate homeostasis mediated by Nir2 at ER-PM junctions...
  30. Garner K, Hunt A, Koster G, Somerharju P, Groves E, Li M, et al. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. J Biol Chem. 2012;287:32263-76 pubmed publisher
    ..an uncharacterized soluble PITP, phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) (alternative name, RdgB?), of the Class II family...
  31. Litvak V, Shaul Y, Shulewitz M, Amarilio R, Carmon S, Lev S. Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain. Curr Biol. 2002;12:1513-8 pubmed
    b>Nir2, like its Drosophila homolog retinal degeneration B (RdgB), contains an N-terminal phosphatidylinositol-transfer protein (PI-TP)-like domain...
  32. Charng J, Cideciyan A, Jacobson S, Sumaroka A, Schwartz S, Swider M, et al. Variegated yet non-random rod and cone photoreceptor disease patterns in RPGR-ORF15-associated retinal degeneration. Hum Mol Genet. 2016;25:5444-5459 pubmed publisher
    ..We also correlated the features observed in patients with those of three Rpgr-mutant (Rpgr-ko, Rd9, and Rpgr-cko) mice. In patients, there was pronounced macular disease...
  33. Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, et al. Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Mol Cell. 2004;14:319-30 pubmed
    ..Here we show that, at the onset of mitosis, Cdk1 phosphorylates the peripheral Golgi protein Nir2 at multiple sites; of these, S382 is the most prominent...
  34. Keinan O, Kedan A, Gavert N, Selitrennik M, Kim S, Karn T, et al. The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis. J Cell Sci. 2014;127:4740-9 pubmed publisher
    ..Here, we show that the lipid-transfer protein Nir2 (also known as PITPNM1) enhances EMT in mammary epithelial and breast cancer cells...
  35. Yadav S, Thakur R, Georgiev P, Deivasigamani S, Krishnan H, Ratnaparkhi G, et al. RDGBα localization and function at membrane contact sites is regulated by FFAT-VAP interactions. J Cell Sci. 2018;131: pubmed publisher
    ..In Drosophila photoreceptors, loss of RDGBα, a multi-domain PITP localized to membrane contact sites (MCSs), results in multiple defects during PLC ..
  36. Kim S, Kedan A, Marom M, Gavert N, Keinan O, Selitrennik M, et al. The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling. EMBO Rep. 2013;14:891-9 pubmed publisher
    ..Here we show that the phosphatidylinositol (PI)-transfer protein Nir2 translocates from the Golgi complex to the plasma membrane in response to GF stimulation...
  37. Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol Cell Biol. 1999;19:2278-88 pubmed
    ..The three Nir proteins (Nir1, Nir2, and Nir3) bind to the amino-terminal domain of PYK2 via a conserved sequence motif located in the carboxy terminus...
  38. Alhuzimi E, Leal L, Sternberg M, David A. Properties of human genes guided by their enrichment in rare and common variants. Hum Mutat. 2017;: pubmed publisher
    ..enriched in rare variants (AOC2, MAMDC4, ANKHD1, CDC42BPB, SPAG5, TRRAP, TANC2, IQCH, USP54, SRRM2, DOPEY2 and PITPNM1) no disease-causing variants have been identified in major, publicly-available databases...
  39. Chang C, Hsieh T, Yang T, Rothberg K, Azizoglu D, Volk E, et al. Feedback regulation of receptor-induced Ca2+ signaling mediated by E-Syt1 and Nir2 at endoplasmic reticulum-plasma membrane junctions. Cell Rep. 2013;5:813-25 pubmed publisher
    ..This subsequently facilitated the recruitment of Nir2, a phosphatidylinositol transfer protein (PITP), to ER-PM junctions following receptor stimulation...
  40. Vihtelic T, Hyde D, O Tousa J. Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene. Genetics. 1991;127:761-8 pubmed
    Retinal degeneration-B (rdgB) mutants of Drosophila melanogaster undergo rapid light-induced retinal degeneration. We conducted a molecular characterization of the rdgB gene to examine the nature of the gene product...