PIM1

Summary

Gene Symbol: PIM1
Description: Pim-1 proto-oncogene, serine/threonine kinase
Alias: PIM, serine/threonine-protein kinase pim-1, Oncogene PIM1, pim-1 kinase 44 kDa isoform, pim-1 oncogene (proviral integration site 1), proto-oncogene serine/threonine-protein kinase pim-1
Species: human
Products:     PIM1

Top Publications

  1. Zhang T, Zhang X, Ding K, Yang K, Zhang Z, Xu Y. PIM-1 gene RNA interference induces growth inhibition and apoptosis of prostate cancer cells and suppresses tumor progression in vivo. J Surg Oncol. 2010;101:513-9 pubmed publisher
    The goal of this study was to investigate the roles of PIM-1 in prostate cancer (CaP) cell proliferation and apoptosis, and to assess the potential of PIM-1 as a target for CaP therapy...
  2. Bajaj B, Verma S, Lan K, Cotter M, Woodman Z, Robertson E. KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activity. Virology. 2006;351:18-28 pubmed
    b>Pim kinases are proto-oncogenes that are upregulated in a number of B cell cancers, including Epstein-Barr Virus (EBV) associated Burkitt's lymphoma...
  3. Bachmann M, Hennemann H, Xing P, Hoffmann I, Moroy T. The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. J Biol Chem. 2004;279:48319-28 pubmed
    The Pim-1 oncogene encodes a serine-threonine kinase that relays signals from cytokine receptors and contributes to the formation of lymphoid tumors when expressed at high levels...
  4. Bhattacharya N, Wang Z, Davitt C, McKenzie I, Xing P, Magnuson N. Pim-1 associates with protein complexes necessary for mitosis. Chromosoma. 2002;111:80-95 pubmed
    The proto-oncogene pim-1 is a serine/threonine kinase the over-expression of which promotes lymphoma formation...
  5. Zhang Y, Wang Z, Magnuson N. Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Mol Cancer Res. 2007;5:909-22 pubmed
    Previous studies from our laboratory showed that p21Cip1/WAF1 can be phosphorylated by Pim-1 kinase in vitro, implying that part of the function of Pim-1 might involve influencing the cell cycle...
  6. Gapter L, Magnuson N, Ng K, Hosick H. Pim-1 kinase expression during murine mammary development. Biochem Biophys Res Commun. 2006;345:989-97 pubmed
    b>Pim-1 kinase phosphorylates substrates whose activities are linked to proliferation, survival, differentiation, and apoptosis...
  7. Weirauch U, Beckmann N, Thomas M, Grünweller A, Huber K, Bracher F, et al. Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma. Neoplasia. 2013;15:783-94 pubmed
    The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis...
  8. Kim H, Kim C, Vo M, Lee H, Lee J, Yoon N, et al. Expression of proviral integration site for Moloney murine leukemia virus 1 (Pim-1) is post-transcriptionally regulated by tristetraprolin in cancer cells. J Biol Chem. 2012;287:28770-8 pubmed publisher
    The proviral integration site for Moloney murine leukemia virus 1 (Pim-1) is an oncogenic serine/threonine kinase that is up-regulated in several human cancers, facilitates cell cycle progression, and suppresses apoptosis...
  9. Reiser Erkan C, Erkan M, Pan Z, Bekasi S, Giese N, Streit S, et al. Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma. Cancer Biol Ther. 2008;7:1352-9 pubmed
    b>Pim-1 is a proto-oncogene involved in cell survival, differentiation and proliferation in several hematologic and epithelial malignancies. Clinically, absence of Pim-1 expression correlates with poor prognosis in prostate cancer...

More Information

Publications74

  1. Shay K, Wang Z, Xing P, McKenzie I, Magnuson N. Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway. Mol Cancer Res. 2005;3:170-81 pubmed
    Elevated expression of the serine/threonine kinase Pim-1 increases the incidence of lymphomas in Pim-1 transgenic mice and has also been found to occur in some human cancers...
  2. Beier U, Weise J, Laudien M, Sauerwein H, Görögh T. Overexpression of Pim-1 in head and neck squamous cell carcinomas. Int J Oncol. 2007;30:1381-7 pubmed
    ..We identified a 127-bp long fragment to be overexpressed in HNSCC cells that revealed a 98.4% homology with the Pim-1 mRNA. The differential expression was confirmed by Northern hybridization...
  3. Xu D, Allsop S, Witherspoon S, Snider J, Yeh J, Fiordalisi J, et al. The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis. 2011;32:488-95 pubmed publisher
    Oncogenic Pim-1 kinase is upregulated in multiple solid cancers, including human pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with few useful treatment options...
  4. Mizuno K, Shirogane T, Shinohara A, Iwamatsu A, Hibi M, Hirano T. Regulation of Pim-1 by Hsp90. Biochem Biophys Res Commun. 2001;281:663-9 pubmed
    The protooncogene Pim-1 encodes serine/threonine protein kinases that are involved in cytokine-mediated cell proliferation and in lymphoma- and leukemogenesis. It is largely unknown how Pim-1 executes its biological effects...
  5. Cottage C, Bailey B, Fischer K, Avitabile D, Avitable D, Collins B, et al. Cardiac progenitor cell cycling stimulated by pim-1 kinase. Circ Res. 2010;106:891-901 pubmed publisher
    Cardioprotective effects of Pim-1 kinase have been previously reported but the underlying mechanistic basis may involve a combination of cellular and molecular mechanisms that remain unresolved...
  6. Macdonald A, Campbell D, Toth R, McLauchlan H, Hastie C, Arthur J. Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. BMC Cell Biol. 2006;7:1 pubmed
    b>Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases...
  7. Bullock A, Debreczeni J, Amos A, Knapp S, Turk B. Structure and substrate specificity of the Pim-1 kinase. J Biol Chem. 2005;280:41675-82 pubmed
    The Pim kinases are a family of three vertebrate protein serine/threonine kinases (Pim-1, -2, and -3) belonging to the CAMK (calmodulin-dependent protein kinase-related) group...
  8. Zemskova M, Sahakian E, Bashkirova S, Lilly M. The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells. J Biol Chem. 2008;283:20635-44 pubmed publisher
    ..Docetaxel activates STAT3 phosphorylation and transcriptional activity, which in turns induces expression of the PIM1 gene, encoding a serine-threonine kinase activated by many cellular stresses...
  9. Thomas M, Lange Grünweller K, Weirauch U, Gutsch D, Aigner A, Grünweller A, et al. The proto-oncogene Pim-1 is a target of miR-33a. Oncogene. 2012;31:918-28 pubmed publisher
    The constitutively active serine/threonine kinase Pim-1 is upregulated in different cancer types, mainly based on the action of several interleukines and growth factors at the transcriptional level...
  10. Guo S, Mao X, Chen J, Huang B, Jin C, Xu Z, et al. Overexpression of Pim-1 in bladder cancer. J Exp Clin Cancer Res. 2010;29:161 pubmed publisher
    b>Pim-1 is a serine-threonine kinase which promotes early transformation, cell proliferation and cell survival during tumorigenesis...
  11. Walpen T, Kalus I, Schwaller J, Peier M, Battegay E, Humar R. Nuclear PIM1 confers resistance to rapamycin-impaired endothelial proliferation. Biochem Biophys Res Commun. 2012;429:24-30 pubmed publisher
    ..We therefore investigated how the PIM1 kinase modulates growth inhibitory effects of rapamycin in mouse aortic endothelial cells (MAEC)...
  12. Xie Y, Burcu M, Linn D, Qiu Y, Baer M. Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression. Mol Pharmacol. 2010;78:310-8 pubmed publisher
    The oncogenic serine/threonine kinase Pim-1 phosphorylates and activates the ATP-binding cassette transporter breast cancer resistance protein (ABCG2)...
  13. Jacobs M, Black J, Futer O, Swenson L, Hare B, Fleming M, et al. Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J Biol Chem. 2005;280:13728-34 pubmed
    b>Pim-1 is an oncogene-encoded serine/threonine kinase primarily expressed in hematopoietic and germ cell lines...
  14. Ionov Y, Le X, Tunquist B, Sweetenham J, Sachs T, Ryder J, et al. Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects. Anticancer Res. 2003;23:167-78 pubmed
    The Pim-1 33-kDa protein is a serine/threonine protein kinase that is capable of enhancing the rate of occurrence of c-Myc-induced lymphomas, and functions to block factor-withdrawal and genotoxic stress-induced apoptosis...
  15. Rainio E, Sandholm J, Koskinen P. Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase. J Immunol. 2002;168:1524-7 pubmed
    b>Pim-1 is an oncogenic serine/threonine kinase implicated in cytokine-induced signal transduction and in development of lymphoid malignancies. However, its precise function as well as physiological substrates have remained unknown...
  16. Nga M, Swe N, Chen K, Shen L, Lilly M, Chan S, et al. PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications. Int J Exp Pathol. 2010;91:34-43 pubmed publisher
    ..We investigated the immunohistochemical expression of PIM-1 kinase in 35 samples of soft tissue tumours using tissue microarray technology and 49 full sections of adipocytic ..
  17. Yan B, Yau E, Samanta S, Ong C, Yong K, Ng L, et al. Clinical and therapeutic relevance of PIM1 kinase in gastric cancer. Gastric Cancer. 2012;15:188-97 pubmed publisher
    Gastric cancer is a leading cause of cancer-related mortality, and chemotherapeutic options are currently limited. PIM1 kinase, an oncogene that promotes tumorigenesis in several cancer types, might represent a novel therapeutic target in ..
  18. Zippo A, De Robertis A, Serafini R, Oliviero S. PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. Nat Cell Biol. 2007;9:932-44 pubmed
    The serine/threonine kinase human Pim1 (hereafter PIM1) cooperates with human c-Myc (hereafter MYC) in cell cycle progression and tumorigenesis. However, the nature of this cooperation is still unknown...
  19. Siu A, Virtanen C, Jongstra J. PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells. Oncotarget. 2011;2:1134-44 pubmed
    The PIM family of oncogenic serine/threonine kinases regulates tumour cell proliferation...
  20. Wang Z, Bhattacharya N, Meyer M, Seimiya H, Tsuruo T, Tonani J, et al. Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells. Arch Biochem Biophys. 2001;390:9-18 pubmed
    The levels of Pim-1, a serine/threonine kinase, increase during phorbol myristate acetate (PMA)-induced myeloid cell differentiation...
  21. Didichenko S, Spiegl N, Brunner T, Dahinden C. IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils. Blood. 2008;112:3949-58 pubmed publisher
    ..cIAP2, Mcl-1, and Bcl-X(L) and induces a rapid and sustained de novo expression of the serine/threonine kinase Pim1 that closely correlates with cytokine-enhanced survival...
  22. Jin Y, Tong D, Chen J, Feng Z, Yang J, Shao C, et al. Overexpression of osteopontin, ?v?3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer. PLoS ONE. 2012;7:e48575 pubmed publisher
    In this study, we examined the expression of osteopontin (OPN), ?v?3 and Pim-1 in non-small cell lung cancer (NSCLC) and investigated the potential clinical implications of their expression patterns in NSCLC...
  23. Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y. Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem. 1999;274:18659-66 pubmed
    The pim-1 oncogene encodes a serine/threonine kinase (Pim-1) involved in the transduction of cytokine-triggered mitogenic signals...
  24. Amson R, Sigaux F, Przedborski S, Flandrin G, Givol D, Telerman A. The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc Natl Acad Sci U S A. 1989;86:8857-61 pubmed
    We measured the human pim-1 protooncogene (PIM) expression during fetal development and in hematopoietic malignancies...
  25. Warnecke Eberz U, Bollschweiler E, Drebber U, Pohl A, Baldus S, Hoelscher A, et al. Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases. Oncol Rep. 2008;20:619-24 pubmed
    b>Pim kinases are emerging as important mediators of cytokine signalling pathways in hematopoietic cells, and contribute to the progression of certain leukemias and solid tumors...
  26. Block K, Hanke N, Maine E, Baker A. IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines. Pancreas. 2012;41:773-81 pubmed publisher
    ..a focus on signal transducer and activator of transcription 3 (STAT3) and proto-oncogene serine/threonine-protein (Pim-1) kinase...
  27. Peltola K, Hollmen M, Maula S, Rainio E, Ristamaki R, Luukkaa M, et al. Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor. Neoplasia. 2009;11:629-36 pubmed
    b>Pim-1 is an oncogenic serine/threonine kinase with poorly defined function in epithelial cancers...
  28. Wang J, Anderson P, Luo W, Gius D, Roh M, Abdulkadir S. Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells. Oncogene. 2012;31:1794-803 pubmed publisher
    b>PIM1 kinase and MYC are commonly co-expressed in human prostate cancer and synergize to induce rapidly progressing prostate cancer in mouse models...
  29. Borillo G, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, et al. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010;106:1265-74 pubmed publisher
    ..b>Pim-1 kinase is an essential downstream effector of AKT-mediated cardioprotection but the mechanistic basis for ..
  30. Meeker T, Nagarajan L, ar Rushdi A, Croce C. Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases. J Cell Biochem. 1987;35:105-12 pubmed
    The mouse PIM-1 gene has been implicated in the evolution of retrovirus-associated mouse lymphomas. We have initiated a study of the human PIM-1 gene because of its potential importance as a human oncogene...
  31. Leverson J, Koskinen P, Orrico F, Rainio E, Jalkanen K, Dash A, et al. Pim-1 kinase and p100 cooperate to enhance c-Myb activity. Mol Cell. 1998;2:417-25 pubmed
    The pim-1 oncogene is regulated by hematopoietic cytokine receptors, encodes a serine/threonine protein kinase, and cooperates with c-myc in lymphoid cell transformation...
  32. Ishibashi Y, Maita H, Yano M, Koike N, Tamai K, Ariga H, et al. Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus. FEBS Lett. 2001;506:33-8 pubmed
    b>Pim-1, an oncogene product of serine/threonine kinase, has been found to play roles in apoptosis induction/suppression, cell-cycle progression and transcriptional regulation by phosphorylating the target proteins involved in these ..
  33. Wang Z, Bhattacharya N, Mixter P, Wei W, Sedivy J, Magnuson N. Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochim Biophys Acta. 2002;1593:45-55 pubmed
    The serine/threonine kinase, Pim-1, appears to be involved in regulating proliferation, differentiation and cell survival of lymphoid and myeloid cells...
  34. Aho T, Sandholm J, Peltola K, Ito Y, Koskinen P. Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity. BMC Cell Biol. 2006;7:21 pubmed
    The pim family genes encode oncogenic serine/threonine kinases which in hematopoietic cells have been implicated in cytokine-dependent signaling as well as in lymphomagenesis, especially in cooperation with other oncogenes such as myc, ..
  35. Qian K, Wang L, Hickey E, Studts J, Barringer K, Peng C, et al. Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. J Biol Chem. 2005;280:6130-7 pubmed
    b>Pim-1 kinase is a member of a distinct class of serine/threonine kinases consisting of Pim-1, Pim-2, and Pim-3...
  36. Roh M, Song C, Kim J, Abdulkadir S. Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1. J Biol Chem. 2005;280:40568-77 pubmed
    Overexpression of the oncogenic serine/threonine kinase Pim-1 has been shown to induce chromosomal missegregation and polyploidy in prostate epithelial cell lines (1)...
  37. Saris C, Domen J, Berns A. The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J. 1991;10:655-64 pubmed
    The pim-1 gene is frequently found activated by proviral insertion in murine T cell lymphomas. Overexpression of pim-1 in lymphoid cells by transgenesis formally proved its oncogenic potential...
  38. Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma V, et al. Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors. Mol Cell Endocrinol. 2013;365:270-6 pubmed publisher
    ..ER? cistromes of MCF-7 breast cancer cells for previously unrecognized ER? targets and identified proto-oncogene PIM-1 as a novel potential target gene...
  39. Schatz J, Oricchio E, Wolfe A, Jiang M, Linkov I, Maragulia J, et al. Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. J Exp Med. 2011;208:1799-807 pubmed publisher
    ..at least in part, by decreased production of short-lived oncoproteins including c-MYC, Cyclin D1, MCL1, and the PIM1/2 kinases themselves...
  40. Thompson J, Peltola K, Koskinen P, Janne O, Palvimo J. Attenuation of androgen receptor-dependent transcription by the serine/threonine kinase Pim-1. Lab Invest. 2003;83:1301-9 pubmed
    ..Recently, an oncogenic serine/threonine kinase, Pim-1, was reported to be overexpressed in prostate cancer...
  41. Valdman A, Fang X, Pang S, Ekman P, Egevad L. Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer. Prostate. 2004;60:367-71 pubmed
    b>PIM-1, an oncogene product of serine/threonine kinase, has been found to play an important role in induction/suppression of apoptosis, cell cycle progression, and transcriptional regulation by phosphorylating the target proteins involved ..
  42. Rainio E, Ahlfors H, Carter K, Ruuska M, Matikainen S, Kieff E, et al. Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity. Virology. 2005;333:201-6 pubmed
    ..Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity of the viral transcriptional activator EBNA2...
  43. Kumar A, Mandiyan V, Suzuki Y, Zhang C, Rice J, Tsai J, et al. Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J Mol Biol. 2005;348:183-93 pubmed
    b>Pim1, a serine/threonine kinase, is involved in several biological functions including cell survival, proliferation, and differentiation...
  44. Warnecke Eberz U, Bollschweiler E, Drebber U, Metzger R, Baldus S, Holscher A, et al. Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer. Anticancer Res. 2009;29:4451-5 pubmed
    b>PIM kinases are mediators of cytokine signalling pathways in hematopoietic cells and contribute to the progression of certain types of leukemia and solid tumor...
  45. Muraski J, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, et al. Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med. 2007;13:1467-75 pubmed
    The serine-threonine kinases Pim-1 and Akt regulate cellular proliferation and survival. Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 has been overlooked...
  46. Jung Y, Chae H, Seoh J, Ryu K, Park H, Kim Y, et al. Pim-1 induced polyploidy but did not affect megakaryocytic differentiation of K562 cells and CD34+ cells from cord blood. Eur J Haematol. 2007;78:131-8 pubmed
    ..lineage cells via serial analysis of gene expression and microarray methods, and demonstrated that Pim-1 was expressed more abundantly in megakaryocytic lineage cells...
  47. He H, Bi X, Zheng Z, Dai Q, Han Z, Liang Y, et al. Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer. Med Oncol. 2009;26:303-8 pubmed publisher
    To investigate the expressions of PIM-1 and hK2 mRNA in normal prostate, benign prostatic glandular hyperplasia (BPH), and prostate cancer (PCa), and to explore the association of PIM-1 and hK2 expressions with PCa progression...
  48. Xie Y, Xu K, Dai B, Guo Z, Jiang T, Chen H, et al. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. Oncogene. 2006;25:70-8 pubmed
    Protein kinase Pim-1 has been implicated in the development of hematopoietic and prostatic malignancies...
  49. Nihira K, Ando Y, Yamaguchi T, Kagami Y, Miki Y, Yoshida K. Pim-1 controls NF-kappaB signalling by stabilizing RelA/p65. Cell Death Differ. 2010;17:689-98 pubmed publisher
    ..Importantly, we identify Pim-1 as a further kinase responsible for the phosphorylation of RelA/p65 at Ser276...
  50. Hu Y, Passegue E, Fong S, Largman C, Lawrence H. Evidence that the Pim1 kinase gene is a direct target of HOXA9. Blood. 2007;109:4732-8 pubmed
    ..Our previous study suggested that HOXA9 positively regulates Pim1, an oncogenic kinase. The hematologic phenotypes of Hoxa9- and Pim1-deficient animals are strikingly similar...
  51. Xie Y, Xu K, Linn D, Yang X, Guo Z, Shimelis H, et al. The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells. J Biol Chem. 2008;283:3349-56 pubmed
    We previously showed that the 44-kDa serine/threonine kinase Pim-1 (Pim-1L) can protect prostate cancer cells from apoptosis induced by chemotherapeutic drugs (Xie, Y., Xu, K., Dai, B., Guo, Z., Jiang, T., Chen, H., and Qiu, Y...
  52. Hogan C, Hutchison C, Marcar L, Milne D, Saville M, Goodlad J, et al. Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma. J Biol Chem. 2008;283:18012-23 pubmed publisher
    ..Here, we address the hypothesis that elevated expression of pim oncogenes might suppress p53 by regulating Mdm2...
  53. Morishita D, Katayama R, Sekimizu K, Tsuruo T, Fujita N. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. 2008;68:5076-85 pubmed publisher
    ..However, the precise mechanisms remain unclear. We show, herein, that all the Pim family members (Pim1, Pim2, and Pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(Kip1) at threonine-..
  54. Linn D, Yang X, Xie Y, Alfano A, Deshmukh D, Wang X, et al. Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases. J Biol Chem. 2012;287:22959-68 pubmed publisher
    ..Here, we report that two PIM-1 kinase isoforms which are up-regulated during prostate cancer progression, namely PIM-1S and PIM-1L, modulate AR ..
  55. Maita H, Harada Y, Nagakubo D, Kitaura H, Ikeda M, Tamai K, et al. PAP-1, a novel target protein of phosphorylation by pim-1 kinase. Eur J Biochem. 2000;267:5168-78 pubmed
    Protooncogene, pim-1, has been reported to be a predisposition for lymphomagenesis along with myc, and its protein product, Pim-1, has been shown to be a serine/threonine protein kinase, whose activity is involved in proliferation and ..
  56. Dhanasekaran S, Barrette T, Ghosh D, Shah R, Varambally S, Kurachi K, et al. Delineation of prognostic biomarkers in prostate cancer. Nature. 2001;412:822-6 pubmed
    ..We assessed two of these genes-hepsin, a transmembrane serine protease, and pim-1, a serine/threonine kinase-at the protein level using tissue microarrays consisting of over 700 clinically ..
  57. Akagi T, Shih L, Ogawa S, Gerss J, Moore S, Schreck R, et al. Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells. Haematologica. 2009;94:1301-6 pubmed publisher
    ..Two samples had copy number neutral loss of heterozygosity on chromosome 6p including the PIM1 gene; and one of these cases had E135K mutation of Pim1...
  58. van der Poel H, Zevenhoven J, Bergman A. Pim1 regulates androgen-dependent survival signaling in prostate cancer cells. Urol Int. 2010;84:212-20 pubmed publisher
    b>Pim1 overexpression was found to be associated with more advanced prostate cancer. Interleukin-6 (IL-6) induces Pim1 expression and is often found elevated after androgen-ablative therapy...
  59. Katare R, Caporali A, Zentilin L, Avolio E, Sala Newby G, Oikawa A, et al. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ Res. 2011;108:1238-51 pubmed publisher
    Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability...
  60. Kim O, Jiang T, Xie Y, Guo Z, Chen H, Qiu Y. Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells. Oncogene. 2004;23:1838-44 pubmed
    ..Here, we present the evidence that two cytoplasmic kinases Pim1 and Etk are involved in this process. We showed that Pim1 is expressed in all prostate cancer cell lines examined...
  61. Li S, Xi Y, Zhang H, Wang Y, Wang X, Liu H, et al. A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation. Oncol Rep. 2010;24:997-1004 pubmed
    It is well documented that Provirus integration site for Moloney murine leukemia virus 1 (Pim-1), as a proto-oncogene encoding a serine/threonine kinase with multiple cellular functions, is tightly associated with the occurrence and ..
  62. Cen B, Mahajan S, Zemskova M, Beharry Z, Lin Y, Cramer S, et al. Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem. 2010;285:29128-37 pubmed publisher
    The Pim-1 protein kinase plays an important role in regulating both cell growth and survival and enhancing transformation by multiple oncogenes...
  63. Bachmann M, Kosan C, Xing P, Montenarh M, Hoffmann I, Moroy T. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol. 2006;38:430-43 pubmed
    The proto-oncogene Pim-1 encodes a serine-threonine kinase which is a downstream effector of cytokine signaling and can enhance cell cycle progression by altering the activity of several cell cycle regulators among them the G1 specific ..
  64. Koike N, Maita H, Taira T, Ariga H, Iguchi Ariga S. Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1). FEBS Lett. 2000;467:17-21 pubmed
    b>Pim-1, a protooncogene product, is a serine/threonine kinase and is thought to play a role in signal transduction in blood cells. Few phosphorylated target proteins for Pim-1, however, have been identified...
  65. Kim D, Sung J, Shin E, Ryu J, Choi I, Park K, et al. Association of single nucleotide polymorphisms in PIM-1 gene with the risk of Korean lung cancer. Cancer Res Treat. 2008;40:190-6 pubmed publisher
    The expression of the PIM-1 gene, which is a proto-oncogene that encodes a serine/threonine kinase, is associated with multiple cellular functions such as proliferation, differentiation, apoptosis and tumorigenesis...