Genomes and Genes
Gene Symbol: PILRB
Description: paired immunoglobin-like type 2 receptor beta
Alias: FDFACT1, FDFACT2, paired immunoglobulin-like type 2 receptor beta, activating receptor PILR-beta, activating receptor PILRbeta, cell surface receptor FDFACT, cell surface receptor FDFACT1, cell surface receptor FDFACT2, paired immunoglobin-like receptor beta, paired immunoglobulin-like receptor beta
- Mousseau D, Banville D, L Abbé D, Bouchard P, Shen S. PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. J Biol Chem. 2000;275:4467-74 pubmed..The PILRalpha and PILRbeta genes are localized to chromosome 7 which is in contrast with the mapping of known members of the inhibitory receptor superfamily. ..
- Fournier N, Chalus L, Durand I, Garcia E, Pin J, Churakova T, et al. FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol. 2000;165:1197-209 pubmed..Thus, FDF03 is a novel ITIM-bearing receptor selectively expressed by cells of myeloid origin, including DC, that may regulate functions other than that of the broadly distributed LAIR-1/p40 molecule. ..
- Wheadon H, Paling N, Welham M. Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cell Signal. 2002;14:219-29 pubmed..These studies suggest that SH2-domain interactions are important for targetting these phosphatases to their substrates. ..
- Zhu Y, Benn S, Li Z, Wei E, Masih Khan E, Trieu Y, et al. The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. J Exp Med. 2004;200:737-47 pubmed..Our study demonstrates that HACS1 is up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. ..