Gene Symbol: PIKFYVE
Description: phosphoinositide kinase, FYVE-type zinc finger containing
Alias: CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29, 1-phosphatidylinositol 3-phosphate 5-kinase, PIPkin-III, epididymis luminal protein 37, phosphatidylinositol 3-phosphate 5-kinase type III, phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III, phosphoinositide kinase, FYVE finger containing, type III PIP kinase, zinc finger, FYVE domain containing 29
Species: human
Products:     PIKFYVE

Top Publications

  1. Ikonomov O, Sbrissa D, Mlak K, Kanzaki M, Pessin J, Shisheva A. Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity. J Biol Chem. 2002;277:9206-11 pubmed
    b>PIKfyve enzymatic activity is required in maintaining late endocytic membrane integrity...
  2. Sbrissa D, Ikonomov O, Shisheva A. Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization. J Biol Chem. 2002;277:6073-9 pubmed
    b>PIKfyve is a phosphatidylinositol (PtdIns) 3-phosphate (P)-metabolizing enzyme, which, in addition to a C-terminally positioned catalytic domain, harbors several evolutionarily conserved domains, including a FYVE finger...
  3. Jiao X, Munier F, Schorderet D, Zografos L, Smith J, Rubin B, et al. Genetic linkage of Francois-Neetens fleck (mouchetée) corneal dystrophy to chromosome 2q35. Hum Genet. 2003;112:593-9 pubmed
    ..We report linkage of the CFD locus to D2S2289 (Z(max)=4.46, theta=0), D2S325 (Z(max)=3.28, theta=0), D2S317 (Z(max)=3...
  4. Sbrissa D, Ikonomov O, Strakova J, Dondapati R, Mlak K, Deeb R, et al. A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. Mol Cell Biol. 2004;24:10437-47 pubmed
    Multivesicular body morphology and size are controlled in part by PtdIns(3,5)P(2), produced in mammalian cells by PIKfyve-directed phosphorylation of PtdIns(3)P...
  5. Nicot A, Fares H, Payrastre B, Chisholm A, Labouesse M, Laporte J. The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans. Mol Biol Cell. 2006;17:3062-74 pubmed
    ..b>Pikfyve/Fab1p is a phosphoinositide kinase that phosphorylates phosphatidylinositol 3-monophosphate into ..
  6. Rutherford A, Traer C, Wassmer T, Pattni K, Bujny M, Carlton J, et al. The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci. 2006;119:3944-57 pubmed
    ..and its mammalian orthologue Pip5k3 encode the phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinases Fab1p and PIKfyve, respectively, enzymes that generates phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)]...
  7. Oppelt A, Lobert V, Haglund K, Mackey A, Rameh L, Liestøl K, et al. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep. 2013;14:57-64 pubmed publisher
    ..migration screen for proteins containing PtdIns3P-binding motifs, we identified the phosphoinositide 5-kinase PIKfyve and the phosphoinositide 3-phosphatase MTMR3, which together constitute a phosphoinositide loop that produces ..
  8. Li S, Tiab L, Jiao X, Munier F, Zografos L, Frueh B, et al. Mutations in PIP5K3 are associated with François-Neetens mouchetée fleck corneal dystrophy. Am J Hum Genet. 2005;77:54-63 pubmed
    ..analysis localized CFD to a 24-cM (18-Mb) interval of chromosome 2q35 flanked by D2S2289 and D2S126 and containing PIP5K3. PIP5K3 is a member of the phosphoinositide 3-kinase family and regulates the sorting and traffic of peripheral ..
  9. Nicot A, Laporte J. Endosomal phosphoinositides and human diseases. Traffic. 2008;9:1240-9 pubmed publisher
    ..Mutations in the gene encoding the PtdIns3P 5-kinase PIP5K3/PIKfyve have been found in patients affected with François-Neetens fleck corneal dystrophy...

More Information

Publications115 found, 100 shown here

  1. Ikonomov O, Sbrissa D, Foti M, Carpentier J, Shisheva A. PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis. Mol Biol Cell. 2003;14:4581-91 pubmed
    The mammalian phosphatidylinositol (PtdIns) 5-P/PtdIns 3,5-P2-producing kinase PIKfyve has been implicated in maintaining endomembrane homeostasis in mammalian cells...
  2. Shisheva A. PIKfyve: Partners, significance, debates and paradoxes. Cell Biol Int. 2008;32:591-604 pubmed publisher
    ..b>PIKfyve, a product of an evolutionarily conserved single-copy gene has both these features...
  3. de Lartigue J, Polson H, Feldman M, Shokat K, Tooze S, Urbé S, et al. PIKfyve regulation of endosome-linked pathways. Traffic. 2009;10:883-93 pubmed
    The phosphoinositide 5-kinase (PIKfyve) is a critical enzyme for the synthesis of PtdIns(3,5)P2, that has been implicated in various trafficking events associated with the endocytic pathway...
  4. Sbrissa D, Ikonomov O, Filios C, Delvecchio K, Shisheva A. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636. Am J Physiol Cell Physiol. 2012;303:C436-46 pubmed publisher
    b>PIKfyve is an essential mammalian lipid kinase with pleiotropic cellular functions whose genetic knockout in mice leads to preimplantation lethality...
  5. Er E, Mendoza M, Mackey A, Rameh L, Blenis J. AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Sci Signal. 2013;6:ra45 pubmed publisher
    ..Upon EGF stimulation, AKT phosphorylated and activated the kinase PIKfyve [FYVE-containing phosphatidylinositol 3-phosphate 5-kinase], which promoted vesicle trafficking to lysosomes...
  6. Oppelt A, Haugsten E, Zech T, Danielsen H, Sveen A, Lobert V, et al. PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. Biochem J. 2014;461:383-90 pubmed publisher
    Previously, we have shown that the phosphoinositide metabolizing enzymes PIKfyve (phosphoinositide 5-kinase, FYVE finger containing) and MTMR3 (myotubularin-related protein 3), together with their lipid product PtdIns5P, are important ..
  7. Ikonomov O, Sbrissa D, Mlak K, Deeb R, Fligger J, Soans A, et al. Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. J Biol Chem. 2003;278:50863-71 pubmed
    b>PIKfyve, a kinase that displays specificity for phosphatidylinositol (PtdIns), PtdIns 3-phosphate (3-P), and proteins, is important in multivesicular body/late endocytic function...
  8. Sbrissa D, Ikonomov O, Fu Z, Ijuin T, Gruenberg J, Takenawa T, et al. Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. J Biol Chem. 2007;282:23878-91 pubmed
    ..Vac14 and human Vac14 (ArPIKfyve), which activate yeast and mammalian PtdIns(3,5)P2-producing enzymes, Fab1 and PIKfyve, respectively...
  9. Jin N, Chow C, Liu L, Zolov S, Bronson R, Davisson M, et al. VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 2008;27:3221-34 pubmed publisher
    ..a scaffold for the PI(3,5)P(2) regulatory complex by direct contact with the known regulators of PI(3,5)P(2): Fig4, Fab1, Vac7 and Atg18...
  10. Jiang C, Sun J, Dai Y, Cao P, Zhang L, Peng S, et al. HIF-1A and C/EBPs transcriptionally regulate adipogenic differentiation of bone marrow-derived MSCs in hypoxia. Stem Cell Res Ther. 2015;6:21 pubmed publisher
    ..as indicated by the accumulation of lipid droplets and the expression of the adipocyte-specific genes leptin, LPL, CFD, PGAR and HIG2. In the extreme hypoxic conditions (0...
  11. Loonam C, O Dell S, Sharp P, Mullen A. Microarray Analysis Reveals Altered Lipid and Glucose Metabolism Genes in Differentiated, Ritonavir-Treated 3T3-L1 Adipocytes. Curr HIV Res. 2016;14:37-46 pubmed
    ..down-regulation of genes responsible for adipocyte triglyceride accumulation including complement factor D (Cfd; 238.42-fold), Cidec (73.75-fold) and Pparg (5.63-fold)...
  12. Tuosto L, Capuano C, Muscolini M, Santoni A, Galandrini R. The multifaceted role of PIP2 in leukocyte biology. Cell Mol Life Sci. 2015;72:4461-74 pubmed publisher
    ..of distinct PIP2 pools, generated by the main PIP2 generating enzyme, phosphatidylinositol 4-phosphate 5-kinase (PIP5K)...
  13. Heyman Lindén L, Seki Y, Storm P, Jones H, Charron M, Berger K, et al. Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. J Nutr Biochem. 2016;27:79-95 pubmed publisher
    ..In contrast, açai-fed mice exhibit marked upregulation of genes associated with steatosis (e.g. Cfd, Cidea, Crat) and lipid and cholesterol biosynthesis, which is in line with the exacerbation of HF-induced hepatic ..
  14. de Luis D, Almansa R, Aller R, Izaola O, Romero E. Gene expression analysis identify a metabolic and cell function alterations as a hallmark of obesity without metabolic syndrome in peripheral blood, a pilot study. Clin Nutr. 2018;37:1348-1353 pubmed publisher
    ..Moreover, PIKFYVE (PtdIns(3) P 5-kinase), and ROCK-2 (rho-kinase II) were under expressed...
  15. Fu Y, Gaelings L, Jalovaara P, Kakkola L, Kinnunen M, Kallio Kokko H, et al. Protein profiling of nasopharyngeal aspirates of hospitalized and outpatients revealed cytokines associated with severe influenza A(H1N1)pdm09 virus infections: A pilot study. Cytokine. 2016;86:10-14 pubmed publisher
    ..of retinol-binding protein 4 (RBP4), C-X-C motif chemokine 5 (CXCL5), interleukin-8 (IL-8), complement factor D (CFD), adiponectin, and chitinase-3-like 1 (CHI3L1) were significantly higher (p<0...
  16. Wang J, Xu M, Wang X, Yang J, Gao L, Zhang Y, et al. Comparative Proteome Analysis Reveals Lipid Metabolism-Related Protein Networks in Response to Rump Fat Mobilization. Int J Mol Sci. 2018;19: pubmed publisher
    ..Furthermore, the upregulation of resistin (RETN), heat-shock protein 72 (HSP72), and complement factor D (CFD) promoted lipolysis, whereas the downregulation of cell death-inducing DFFA-like effector C (CIDEC) inhibited lipid ..
  17. Chakrabarti R, Sanyal S, Ghosh A, Bhar K, Das C, Siddhanta A. Phosphatidylinositol-4-phosphate 5-Kinase 1α Modulates Ribosomal RNA Gene Silencing through Its Interaction with Histone H3 Lysine 9 Trimethylation and Heterochromatin Protein HP1-α. J Biol Chem. 2015;290:20893-903 pubmed publisher
    ..We have shown previously that the nuclear form of phosphatidylinositol-4-phosphate 5-kinase 1α (PIP5K), the enzyme responsible for phosphatidylinositol 4,5-bisphosphate synthesis, is modified by small ubiquitin-like ..
  18. Liu P, Thomson B, Khalatyan N, Feng L, Liu X, Savas J, et al. Selective permeability of mouse blood-aqueous barrier as determined by 15N-heavy isotope tracing and mass spectrometry. Proc Natl Acad Sci U S A. 2018;115:9032-9037 pubmed publisher
    ..detected markedly enhanced permeability to inhibitory complement regulator proteins, such as Cfh, Cfhr, Cfb, Cfi, Cfd, and Vtn...
  19. Lenk G, Szymanska K, Debska Vielhaber G, Rydzanicz M, Walczak A, Bekiesinska Figatowska M, et al. Biallelic Mutations of VAC14 in Pediatric-Onset Neurological Disease. Am J Hum Genet. 2016;99:188-94 pubmed publisher
    In the PI(3,5)P2 biosynthetic complex, the lipid kinase PIKFYVE and the phosphatase FIG4 are bound to the dimeric scaffold protein VAC14, which is composed of multiple heat-repeat domains...
  20. Ryou M, Choudhury G, Li W, Winters A, Yuan F, Liu R, et al. Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress. Neuroscience. 2015;301:193-203 pubmed publisher
    ..changes were measured by immunoblot: HIF-1α, prolyl hydroxylase 2 (PHD2), erythropoietin (EPO), Akt, mTOR, and PIP5K. The contribution of HIF-1α activation in the MB-induced neuroprotective mechanism was confirmed by blocking ..
  21. Hase K, Kanda A, Hirose I, Noda K, Ishida S. Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy. PLoS ONE. 2017;12:e0189696 pubmed publisher
    ..Protein levels of s(P)RR, prorenin, tumor necrosis factor (TNF)-?, complement factor D (CFD), and leucine-rich ?-2-glycoprotein 1 (LRG1) significantly increased in the plasma of PDR subjects as compared to ..
  22. Li J, Song L, Zhou L, Wu J, Sheng C, Chen H, et al. A MicroRNA Signature in Gestational Diabetes Mellitus Associated with Risk of Macrosomia. Cell Physiol Biochem. 2015;37:243-52 pubmed publisher
    ..We found that the protein levels of EGFR, PI3K and phospho-Akt were up-regulated and PIKfyve (a FYVE finger-containing phosphoinositide kinase), a negative regulator of EGFR signaling, was down-regulated ..
  23. Rai M, Tycksen E, Cai L, Yu J, Wright R, Brophy R. Distinct degenerative phenotype of articular cartilage from knees with meniscus tear compared to knees with osteoarthritis. Osteoarthritis Cartilage. 2019;: pubmed publisher
    ..Among these, CFD, CSN1S1, TSPAN11, CSF1R and CD14 were elevated in the TKA group, while CHI3L2, HILPDA, COL3A1, COL27A1 and FGF2 ..
  24. Honnemyr M, Bruserud Ø, Brenner A. The constitutive protease release by primary human acute myeloid leukemia cells. J Cancer Res Clin Oncol. 2017;143:1985-1998 pubmed publisher
    ..C), coagulation (ADAM TS13, serpin C1), inflammation (fetuin A, caspase 1, cystatin C), monocytic differentiation (CFD) or regulation of hematopoiesis (neutrophil elastase)...
  25. Nelson E, Dyall J, Hoenen T, Barnes A, Zhou H, Liang J, et al. The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection. PLoS Negl Trop Dis. 2017;11:e0005540 pubmed publisher
    Phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) is a lipid kinase involved in endosome maturation that emerged from a haploid genetic screen as being required for Ebola virus (EBOV) infection...
  26. Sartain S, Turner N, Moake J. Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells. J Biol Chem. 2018;293:7195-7208 pubmed publisher
    ..gene expression of the AP-related genes C3, CFB, and C5 and decreased expression of CFD This was associated with increased expression in BMVECs (relative to GMVECs) of the genes for surface and ..
  27. Cui Q, Xie P. Correlation Between Daam2 Expression Changes and Demyelination in Guillain-Barre Syndrome. Cell Mol Neurobiol. 2016;36:683-8 pubmed publisher
    ..of Daam2, disheveled-associated activator of morphogenesis, a key Wnt signaling downstream effector, and PIP5K is changed in the demyelinating conditions and under different stages of progress of clinical recovery of patients ..
  28. Qiu S, Leung A, Bo Y, Kozak R, Anand S, Warkentin C, et al. Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry. Virology. 2018;513:17-28 pubmed publisher
    ..Here, we show that the PIKfyve-ArPIKfyve-Sac3 cellular complex, which is involved in the metabolism of phosphatidylinositol (3,5) bisphosphate (..
  29. Vulović A, Šušteršič T, Cvijić S, Ibric S, Filipovic N. Coupled in silico platform: Computational fluid dynamics (CFD) and physiologically-based pharmacokinetic (PBPK) modelling. Eur J Pharm Sci. 2018;113:171-184 pubmed publisher
    ..The aim of this study was to link the Computational fluid dynamics (CFD) with physiologically-based pharmacokinetic (PBPK) modelling in order to predict aerolisolization of different dry ..
  30. Khan T, Sheh Zad H, Lazoglu I, Yalcin O. Development of a novel shrouded impeller pediatric blood pump. J Artif Organs. 2018;21:142-149 pubmed publisher
    ..Computational Fluid Dynamics (CFD) simulations were performed to analyze the optimized design...
  31. Ranganathan P, Savithri S. Computational Fluid Dynamics simulation of hydrothermal liquefaction of microalgae in a continuous plug-flow reactor. Bioresour Technol. 2018;258:151-157 pubmed publisher
    Computational Fluid Dynamics (CFD) technique is used in this work to simulate the hydrothermal liquefaction of Nannochloropsis sp...
  32. Kim J, Jahng W, Di Vizio D, Lee J, Jhaveri R, Rubin M, et al. The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus. Cancer Res. 2007;67:9229-37 pubmed
    ..of EGFR immune complexes from a transitional carcinoma cell line (TCCSUP) identified the phosphoinositide kinase, PIKfyve, as a potential component of the EGFR trafficking mechanism...
  33. Cai X, Xu Y, Kim Y, Loureiro J, Huang Q. PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3. J Immunol. 2014;192:3383-9 pubmed publisher
    ..In this study, we find that PIKfyve, a class III lipid kinase, is required for endolysosomal TLR-induced expression of type I IFN in mouse and human ..
  34. Kojima M, Irie K, Masunaga K, Sakai Y, Nakajima M, Takeuchi M, et al. Hybrid stent device of flow-diverting effect and stent-assisted coil embolization formed by fractal structure. Med Biol Eng Comput. 2016;54:831-41 pubmed publisher
    ..Flow-diverting effects were analyzed using computational fluid dynamics (CFD) analysis and particle image velocimetry (PIV) experiment...
  35. Xu Q, Zhang Y, Wei Q, Huang Y, Hu J, Ling K. Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis. Nat Commun. 2016;7:10777 pubmed publisher
    ..Our results reveal that PtdIns(4)P homoeostasis, coordinated by PIPKIγ and INPP5E at the centrosome/ciliary base, is vital for ciliogenesis by regulating the CEP164-dependent recruitment of TTBK2. ..
  36. Leung C, Tong Z, Zhou Q, Chan J, Tang P, Sun S, et al. Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-Based DPI Formulations. Part 1: Grid Structure. AAPS J. 2016;18:1159-67 pubmed publisher
    ..A coupled CFD-discrete element method analysis was employed to determine the flow characteristics and particle impaction...
  37. Morakinyo T, Lam Y. Study of traffic-related pollutant removal from street canyon with trees: dispersion and deposition perspective. Environ Sci Pollut Res Int. 2016;23:21652-21668 pubmed
    ..and tree planting pattern under different wind conditions were conducted using a computational fluid dynamics (CFD) model, ENVI-met...
  38. Negin Mortazavi S, GEDDES D, Hassanipour F. Lactation in the Human Breast From a Fluid Dynamics Point of View. J Biomech Eng. 2017;139: pubmed publisher
    ..results for suckling pressure pattern in lactating human breast as well as a 3D computational fluid dynamics (CFD) modeling of milk flow using these clinical inputs...
  39. Wang T, Feugang J, Crenshaw M, Regmi N, Blanton J, Liao S. A Systems Biology Approach Using Transcriptomic Data Reveals Genes and Pathways in Porcine Skeletal Muscle Affected by Dietary Lysine. Int J Mol Sci. 2017;18: pubmed publisher
    ..i>HSP90AA1, HSPH1, and UBE2D3 mRNA; and (2) reduced lipid biosynthesis via the down-regulated CFD and ME1 mRNA...
  40. Cuesta Geijo M, Barrado Gil L, Galindo I, Muñoz Moreno R, Alonso C. Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site. Viruses. 2017;9: pubmed publisher
    ..Virus replication also depends on endosomal membrane phosphoinositides (PtdIns) synthesized by PIKfyve. Endosomes could act as platforms providing membranes and PtdIns, necessary for ASFV replication...
  41. Galarza M, Gimenez A, Amigo J, Schuhmann M, Gazzeri R, Thomale U, et al. Next generation of ventricular catheters for hydrocephalus based on parametric designs. Childs Nerv Syst. 2018;34:267-276 pubmed publisher
    ..was studied under steady and, recently, in pulsatile boundary conditions by means of computational fluid dynamics (CFD) in three-dimensional catheter models...
  42. Nie P, Xu X, Tang Y, Wang X, Xue X, Wu Y, et al. Computational fluid dynamics simulation of the upper airway of obstructive sleep apnea syndrome by Muller maneuver. J Huazhong Univ Sci Technolog Med Sci. 2015;35:464-468 pubmed publisher
    ..CT data in DICOM format were transformed into an anatomically three-dimensional computational fluid dynamics (CFD) model of the upper airway. The velocity magnitude, relative pressure, and flow distribution were obtained...
  43. Le O, Cho O, Tran M, Kim J, Chang S, Jou I, et al. Phosphorylation of phosphatidylinositol 4-phosphate 5-kinase γ by Akt regulates its interaction with talin and focal adhesion dynamics. Biochim Biophys Acta. 2015;1853:2432-43 pubmed publisher
    The type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family members and their lipid product, phosphatidylinositol 4,5-bisphosphate (PIP2) are important regulators of actin cytoskeleton...
  44. IÅ¡tvanić T, Vrselja Z, Brkić H, Radić R, LekÅ¡an I, Curić G. Extended Eversion Carotid Endarterectomy: Computation of Hemodynamics. Ann Vasc Surg. 2015;29:1598-605 pubmed publisher
    ..Aiming to investigate hemodynamics after different surgical approaches, we created computational fluid dynamics (CFD) models of exeCEA and eCEA with included progressing lumen narrowing, representation of artery restenosis at the ..
  45. Karmonik C, Anderson J, Beilner J, Ge J, Partovi S, Klucznik R, et al. Relationships and redundancies of selected hemodynamic and structural parameters for characterizing virtual treatment of cerebral aneurysms with flow diverter devices. J Biomech. 2016;49:2112-2117 pubmed publisher
    ..Steady computational fluid dynamics (CFD) simulations were performed for 10 cerebral aneurysms where FDD treatment with the SILK device was simulated by ..
  46. Zhong J, Cai X, Bloss W. Coupling dynamics and chemistry in the air pollution modelling of street canyons: A review. Environ Pollut. 2016;214:690-704 pubmed publisher
    ..Dynamical processes can be represented by Computational Fluid Dynamics (CFD) techniques...
  47. Daigger G, Siczka J, Smith T, Frank D, McCorquodale J. Characterizing shallow secondary clarifier performance where conventional flux theory over-estimates allowable solids loading rate. Water Sci Technol. 2016;74:324-32 pubmed publisher
    ..and flocculated total suspended solids), and the results were used to calibrate computational fluid dynamic (CFD) models of the various clarifiers tested...
  48. Rahimi M, Movahedirad S, Shahhosseini S. CFD study of the flow pattern in an ultrasonic horn reactor: Introducing a realistic vibrating boundary condition. Ultrason Sonochem. 2017;35:359-374 pubmed publisher
    ..After developing and validating the numerical model, the model was utilized to predict various quantities such as cavitation zone, pressure field and stream function that are not experimentally feasible to measure. ..
  49. Mofrad A, Mashayekhan S, Bastani D. Simulation of the effects of oxygen carriers and scaffold geometry on oxygen distribution and cell growth in a channeled scaffold for engineering myocardium. Math Biosci. 2017;294:160-171 pubmed publisher
    ..geometry on oxygen distribution and cell growth in a 3D cardiac construct using computational fluid dynamics (CFD)...
  50. Rouvinov K, Mermershtain W, Dresler H, Ariad S, Riff R, Shani Shrem N, et al. Circulating Cell-Free DNA Levels in Patients with Metastatic Renal Cell Carcinoma. Oncol Res Treat. 2017;40:707-710 pubmed publisher
    Limited data about biomarkers are available to predict the outcomes of targeted therapy in metastatic renal cell carcinoma (mRCC). Circulating cell-free DNA (CFD) is elevated in various cancers.
  51. Song X, Zhang Y, Xue J, Li C, Wang Z, Wang Y. Enhancing nemadectin production by Streptomyces cyaneogriseus ssp. noncyanogenus through quantitative evaluation and optimization of dissolved oxygen and shear force. Bioresour Technol. 2018;255:180-188 pubmed publisher
    ..KLa) and shear stress were quantitatively studied through computational fluid dynamics simulation (CFD)...
  52. Cesani M, Garraza M, Bergel Sanchís M, Luis M, Torres M, Quintero F, et al. A comparative study on nutritional status and body composition of urban and rural schoolchildren from Brandsen district (Argentina). PLoS ONE. 2013;8:e52792 pubmed publisher
    ..Central fat distribution (CFD) was estimated using the subscapular-tricipital index...
  53. Martin B, Yiallourou T, Pahlavian S, Thyagaraj S, Bunck A, Loth F, et al. Inter-operator Reliability of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Cerebrospinal Fluid Motion in the Cervical Spine. Ann Biomed Eng. 2016;44:1524-37 pubmed publisher
    For the first time, inter-operator dependence of MRI based computational fluid dynamics (CFD) modeling of cerebrospinal fluid (CSF) in the cervical spinal subarachnoid space (SSS) is evaluated...
  54. Aramburu J, Antón R, Rivas A, Ramos J, Sangro B, Bilbao J. Liver cancer arterial perfusion modelling and CFD boundary conditions methodology: a case study of the haemodynamics of a patient-specific hepatic artery in literature-based healthy and tumour-bearing liver scenarios. Int j numer method biomed eng. 2016;32: pubmed publisher
    ..Copyright © 2016 John Wiley & Sons, Ltd. ..
  55. Sajjadi H, Tavakoli B, Ahmadi G, Dhaniyala S, Harner T, Holsen T. Computational fluid dynamics (CFD) simulation of a newly designed passive particle sampler. Environ Pollut. 2016;214:410-418 pubmed publisher
    In this work a series of computational fluid dynamics (CFD) simulations were performed to predict the deposition of particles on a newly designed passive dry deposition (Pas-DD) sampler...
  56. Compton L, Ikonomov O, Sbrissa D, Garg P, Shisheva A. Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency. Am J Physiol Cell Physiol. 2016;311:C366-77 pubmed publisher
    The two evolutionarily conserved mammalian lipid kinases Vps34 and PIKfyve are involved in an important physiological relationship, whereby the former produces phosphatidylinositol (PtdIns) 3P that is used as a substrate for PtdIns(3,5)..
  57. Otani T, Ii S, Shigematsu T, Fujinaka T, Hirata M, Ozaki T, et al. Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm. Med Biol Eng Comput. 2017;55:697-710 pubmed publisher
    ..configuration on the blood flow characteristics in a coil-embolized aneurysm using computational fluid dynamics (CFD) simulation...
  58. Li X, Xu C, Luo Y, Zhang S, Huang C, Zou K, et al. Influence of the flow field on ?-cyclodextrin glycosyltransferase production by Escherichia coli BL21. Bioprocess Biosyst Eng. 2018;41:819-829 pubmed publisher
    The computational fluid dynamics (CFD) software package Fluent was utilized to simulate the flow field of Escherichia coli (E...
  59. Piper D, Romanow W, Gunawardane R, Fordstrom P, Masterman S, Pan O, et al. The high-resolution crystal structure of human LCAT. J Lipid Res. 2015;56:1711-9 pubmed publisher
    ..Mapping the naturally occurring mutations onto the structure provides insight into how they may affect LCAT enzymatic activity. ..
  60. Liu J, Ji Y, Zhou J, Xing D. Phosphatidylinositol 3-Kinase Promotes Activation and Vacuolar Acidification and Delays Methyl Jasmonate-Induced Leaf Senescence. Plant Physiol. 2016;170:1714-31 pubmed publisher
    ..Vacuolar acidification was suppressed by the PIKfyve inhibitor in 35S:AtVPS34-YFP Arabidopsis during MeJA-induced leaf senescence, but the decrease was lower than ..
  61. Campos Marin A, Grossi T, Bianchi E, Dubini G, Lacroix D. 2D µ-Particle Image Velocimetry and Computational Fluid Dynamics Study Within a 3D Porous Scaffold. Ann Biomed Eng. 2017;45:1341-1351 pubmed publisher
    ..Computational fluid dynamics (CFD) models can resolve 3D flows and nutrient concentrations in bioreactors at the scaffold-pore scale with high ..
  62. Yu Y, Yang Z, Duan Y. Structure and flow calculation of cake layer on microfiltration membranes. J Environ Sci (China). 2017;56:95-101 pubmed publisher
    ..of the cake layer was reconstructed, and the internal flow was calculated using computational fluid dynamics (CFD)...
  63. Longest P, Hindle M. Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition. Pharm Res. 2017;34:2049-2065 pubmed publisher
    ..A computational fluid dynamics (CFD)-based model of drug dissolution, absorption and clearance occurring in the surface liquid of a representative ..
  64. Itu L, Rapaka S, Passerini T, Georgescu B, Schwemmer C, Schoebinger M, et al. A machine-learning approach for computation of fractional flow reserve from coronary computed tomography. J Appl Physiol (1985). 2016;121:42-52 pubmed publisher
    ..Average execution time went down from 196.3 ± 78.5 s for the CFD model to ?2.4 ± 0.44 s for the machine-learning model on a workstation with 3.4-GHz Intel i7 8-core processor.
  65. Ma Z, Li J, Zhang Y, Shan C, Gao X. Inheritance mode and mechanisms of resistance to imidacloprid in the house fly Musca domestica (Diptera:Muscidae) from China. PLoS ONE. 2017;12:e0189343 pubmed publisher
    ..Compared to the field strain (CFD), the N-IRS strain developed more cross-resistance to chlorfenapyr and no cross-resistance to chlorpyrifos and ..
  66. Gehring E, Zurn A, Klaus F, Laufer J, Sopjani M, Lindner R, et al. Regulation of the glutamate transporter EAAT2 by PIKfyve. Cell Physiol Biochem. 2009;24:361-8 pubmed publisher
    ..Phosphorylation targets of SGK1 include the human phosphatidylinositol-3-phosphate-5-kinase PIKfyve (PIP5K3). Nothing is known, however, on the role of PIKfyve in the regulation of EAAT2...
  67. Ferroni M, Giusti S, Nascimento D, Silva A, Boschetti F, Ahluwalia A. Modeling the fluid-dynamics and oxygen consumption in a porous scaffold stimulated by cyclic squeeze pressure. Med Eng Phys. 2016;38:725-32 pubmed publisher
    ..In this work, we present a new approach for optimizing computational fluid-dynamics (CFD) models for the investigation of fluid-induced forces generated by cyclic squeeze pressure within a porous ..
  68. Bonfanti M, Balabani S, Greenwood J, Puppala S, Homer Vanniasinkam S, Diaz Zuccarini V. Computational tools for clinical support: a multi-scale compliant model for haemodynamic simulations in an aortic dissection based on multi-modal imaging data. J R Soc Interface. 2017;14: pubmed publisher
    ..Aortic dissection (AD) is a vascular condition with high morbidity and mortality rates. Computational fluid dynamics (CFD) can provide insight into the progression of AD and aid clinical decisions; however, oversimplified modelling ..
  69. Ikonomov O, Sbrissa D, Fenner H, Shisheva A. PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis. J Biol Chem. 2009;284:35794-806 pubmed publisher
    The phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P(2)) metabolizing enzymes, the kinase PIKfyve and the phosphatase Sac3, constitute a single multiprotein complex organized by the PIKfyve regulator ArPIKfyve and its ability to ..
  70. Yu D, Yang M, Qi L, Liu M, Wang Y, Wei Y. Effects of aeration on matrix temperature by infrared thermal imager and computational fluid dynamics during sludge bio-drying. Water Res. 2017;122:317-328 pubmed publisher
    ..using thermocouples and Infrared Thermal Imager (IRI) for temperature sensing, and Computational Fluid Dynamics (CFD) for modelling of temperature variation during aeration in a full-scale sludge biodrying plant...
  71. Choi H, Luo T, Navia J, Kassab G. Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models. Sci Rep. 2017;7:7065 pubmed publisher
    ..We performed computational fluid dynamics (CFD) simulations to determine the variations of AF-induced stroke propensity over various image-based patient-dependent ..
  72. Martorina F, Casale C, Urciuolo F, Netti P, Imparato G. In vitro activation of the neuro-transduction mechanism in sensitive organotypic human skin model. Biomaterials. 2017;113:217-229 pubmed publisher
    ..Moreover, through a computational fluid dynamic (CFD) analysis, we set fluid dynamic conditions for a non-planar skin equivalent growth, as proof of potential ..
  73. Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, et al. Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. Blood. 2017;129:1768-1778 pubmed publisher
    ..Apilimod exhibits exquisite specificity for phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) lipid kinase and has selective cytotoxic activity in B-cell non-Hodgkin lymphoma (B-NHL) compared with normal ..
  74. Kitajima H, Oshima M, Iwai T, Ohhara Y, Yajima Y, Mitsudo K, et al. Computational fluid dynamics study of intra-arterial chemotherapy for oral cancer. Biomed Eng Online. 2017;16:57 pubmed publisher
    ..agent into the branches of the ECA in several IAC methods was investigated using computational fluid dynamics (CFD). Patient-specific three-dimensional vessel models were created from CT images of 2 patients with tongue cancer...
  75. Paliwal N, Damiano R, Varble N, Tutino V, Dou Z, Siddiqui A, et al. Methodology for Computational Fluid Dynamic Validation for Medical Use: Application to Intracranial Aneurysm. J Biomech Eng. 2017;139: pubmed publisher
    Computational fluid dynamics (CFD) is a promising tool to aid in clinical diagnoses of cardiovascular diseases. However, it uses assumptions that simplify the complexities of the real cardiovascular flow...
  76. Cabezas A, Pattni K, Stenmark H. Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1. Gene. 2006;371:34-41 pubmed
    ..Here we have cloned and sequenced the cDNA for the human homologue of Fab1, PIKfyve. The cDNA has an open reading frame of 6294 bp and encodes a 2098-amino acid protein with a calculated molecular ..
  77. Kaminsky R, Dumont K, Weber H, Schroll M, Verdonck P. PIV validation of blood-heart valve leaflet interaction modelling. Int J Artif Organs. 2007;30:640-8 pubmed
    The aim of this study was to validate the 2D computational fluid dynamics (CFD) results of a moving heart valve based on a fluid-structure interaction (FSI) algorithm with experimental measurements...
  78. Guo S, Jiang P, Liu J, Yang X, Jiang C, Li Y, et al. A comparative CFD analysis of common carotid fusiform aneurysm in canine models and vertebrobasilar fusiform aneurysm in human patients. Int Angiol. 2018;37:32-40 pubmed publisher
  79. Jiménez Saelices C, Seantier B, Cathala B, Grohens Y. Spray freeze-dried nanofibrillated cellulose aerogels with thermal superinsulating properties. Carbohydr Polym. 2017;157:105-113 pubmed publisher
    ..and thermal insulation properties were compared to those of NFC aerogels prepared by conventional freeze-drying (CFD). The purpose of this investigation is to develop superinsulating bioaerogels by reducing their pore size...
  80. Gardan N, Schneider A, Polidori G, Trenchard H, Seigneur J, Beaumont F, et al. Numerical investigation of the early flight phase in ski-jumping. J Biomech. 2017;59:29-34 pubmed publisher
    ..aerodynamic behavior of the ski jumper and his equipment during the early flight phase of the ski jump, we applied CFD methodology to evaluate the influence of angle of attack (?=14°, 21.5°, 29°, 36...
  81. Martinez A, McMahon R, Horner M, Miller W. A uniform-shear rate microfluidic bioreactor for real-time study of proplatelet formation and rapidly-released platelets. Biotechnol Prog. 2017;: pubmed publisher
    ..In this study, we performed a computational fluid dynamics (CFD) analysis of several published platelet microbioreactor systems, and used the results to develop a new 7-µm slit ..
  82. Roloff C, Berg P, Redel T, Janiga G, Thévenin D. Tomographic particle image velocimetry for the validation of hemodynamic simulations in an intracranial aneurysm. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:1340-1343 pubmed publisher
    ..Additionally, computational fluid dynamics (CFD) simulations were carried out using a well accepted commercial software package and a clinical research prototype, ..
  83. Valentini V, Cassoni A, Terenzi V, Della Monaca M, Fadda M, Rajabtork Zadeh O, et al. Our experience in the surgical management of craniofacial fibrous dysplasia: what has changed in the last 10 years?. Acta Otorhinolaryngol Ital. 2017;37:436-443 pubmed publisher
    The mainstay of treatment of craniofacial dysplasia (CFD) remains surgery once clinical observation has been excluded. Nevertheless, disagreement remains about the type of surgical intervention (remodelling versus radical resection)...
  84. Itzel F, Gehrmann L, Bielak H, Ebersbach P, Boergers A, Herbst H, et al. Investigation of full-scale ozonation at a municipal wastewater treatment plant using a toxicity-based evaluation concept. J Toxicol Environ Health A. 2017;80:1242-1258 pubmed publisher
    ..Based on computational fluid dynamics (CFD) simulations and biomass, one might conclude that O3 did not apparently enter biological posttreatment ..
  85. Piergiovanni M, Bianchi E, Capitani G, Li Piani I, Ganzer L, Guidotti L, et al. Microcirculation in the murine liver: a computational fluid dynamic model based on 3D reconstruction from in vivo microscopy. J Biomech. 2017;63:125-134 pubmed publisher
    ..Herein, we built a CFD model of a 3D sinusoidal network, based on in vivo images of a physiological mouse liver obtained with a 2-photon ..
  86. Jang S, Ahn J, Kim B, Gu J, Sung H, Park S, et al. Comparison of Accuracy of One-Use Methods for Calculating Fractional Flow Reserve by Intravascular Optical Coherence Tomography to That Determined by the Pressure-Wire Method. Am J Cardiol. 2017;120:1920-1925 pubmed publisher
    ..We developed 2 methods to derive FFR-OCT by AFD (FFR-OCTAFD) and FFR-OCT by CFD (FFR-OCTCFD)...
  87. Stoiber M, Grasl C, Pirker S, Huber L, Gittler P, Schima H. Experimental validation of numerical simulations: a comparison of computational fluid dynamics and the oil film method. Int J Artif Organs. 2007;30:363-8 pubmed
    Today Computational Fluid Dynamics (CFD) is used for simulating flow in many applications. The quality of the results, however, depends on various factors, like grid quality, boundary conditions and the computational model of the fluid...
  88. Hormes M, Borchardt R, Mager I, Rode T, Behr M, Steinseifer U. A validated CFD model to predict O? and CO? transfer within hollow fiber membrane oxygenators. Int J Artif Organs. 2011;34:317-25 pubmed
    ..In this study, a modified CFD model is developed and validated with a specially developed micro membrane oxygenator (MicroMox)...
  89. Ben Haj Slama R, Gilles B, Ben Chiekh M, Bera J. PIV for the characterization of focused field induced acoustic streaming: seeding particle choice evaluation. Ultrasonics. 2017;76:217-226 pubmed publisher
    ..small particles (5?m-diameter) velocity measurements were in good agreement with the Computational Fluid Dynamics (CFD) simulations of the water velocity field...
  90. Jin N, Jin Y, Weisman L. Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome. J Cell Biol. 2017;216:2075-2090 pubmed publisher
    ..We show that Pho85/CDK5 directly phosphorylates and positively regulates the PI3P-5 kinase Fab1/PIKfyve complex and provide evidence that this regulation is conserved in mammalian cells...
  91. Kuschel M, Siebler F, Takors R. Lagrangian Trajectories to Predict the Formation of Population Heterogeneity in Large-Scale Bioreactors. Bioengineering (Basel). 2017;4: pubmed publisher
    ..silico method to predict the formation of population heterogeneity by combining computational fluid dynamics (CFD) with a cell cycle model of Pseudomonas putida KT2440 was developed...
  92. Lecompte O, Poch O, Laporte J. PtdIns5P regulation through evolution: roles in membrane trafficking?. Trends Biochem Sci. 2008;33:453-60 pubmed publisher
    ..By examining PtdIns5P metabolism in this new perspective, we propose a role for PtdIns5P in membrane trafficking from late endosomal compartments to the plasma membrane. ..