PIK3R2

Summary

Gene Symbol: PIK3R2
Description: phosphoinositide-3-kinase regulatory subunit 2
Alias: MPPH, MPPH1, P85B, p85, p85-BETA, phosphatidylinositol 3-kinase regulatory subunit beta, PI3-kinase subunit p85-beta, PI3K regulatory subunit beta, phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta), phosphoinositide-3-kinase regulatory subunit beta, phosphoinositide-3-kinase, regulatory subunit 2 (beta), ptdIns-3-kinase regulatory subunit p85-beta
Species: human
Products:     PIK3R2

Top Publications

  1. Blagoveshchenskaya A, Thomas L, Feliciangeli S, Hung C, Thomas G. HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell. 2002;111:853-66 pubmed
    ..These data provide new insights into the cellular basis of HIV-1 immunoevasion. ..
  2. Li Y, Anderson D, Liu Q, Zhou Y. Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity. J Biol Chem. 2008;283:23397-409 pubmed publisher
    ..Finally, the mechanism by which binding of NS1 to p85beta regulates PI3K activity was discussed based on a predicted structural model of NS1-p85-p110 complex.
  3. Inukai K, Funaki M, Anai M, Ogihara T, Katagiri H, Fukushima Y, et al. Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations. FEBS Lett. 2001;490:32-8 pubmed
    ..These results suggest that each isoform possesses specific roles in signal transduction, based on its individual tyrosine kinase receptor. ..
  4. Swann S, Williams M, Story C, Bobbitt K, Fleis R, Collins K. HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway. Virology. 2001;282:267-77 pubmed
    ..We propose that Nef diverts MHC-1 proteins into a PI 3-kinase-dependent transport pathway that prevents expression on the cell surface. ..
  5. Deregibus M, Cantaluppi V, Doublier S, Brizzi M, Deambrosis I, Albini A, et al. HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. J Biol Chem. 2002;277:25195-202 pubmed
  6. Kasper M, Collins K. Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells. J Virol. 2003;77:3041-9 pubmed
  7. Schulze W, Deng L, Mann M. Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 2005;1:2005.0008 pubmed
    ..Our results demonstrate that system-wide mapping of peptide-protein interactions sites is possible, and suggest shared and unique roles of ErbB-receptor family members in downstream signaling. ..
  8. Hale B, Jackson D, Chen Y, Lamb R, Randall R. Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci U S A. 2006;103:14194-9 pubmed
    ..These data suggest that activation of PI3K signaling in influenza A virus-infected cells is important for efficient virus replication. ..
  9. Chugh P, Fan S, Planelles V, Maggirwar S, Dewhurst S, Kim B. Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. J Mol Biol. 2007;366:67-81 pubmed
    ..We propose that the expression of Tat may enable HIV-1 infected microglia to survive throughout the course of infection, leading to persistent HIV-1 production and infection in the central nervous system. ..

More Information

Publications122 found, 100 shown here

  1. Shin Y, Li Y, Liu Q, Anderson D, Babiuk L, Zhou Y. SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation. J Virol. 2007;81:12730-9 pubmed
    ..activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by binding of influenza NS1 protein to the p85 regulatory subunit of PI3K...
  2. Chen X, Cheng L, Jia X, Zeng Y, Yao S, Lv Z, et al. Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice. Neoplasia. 2009;11:1272-84 pubmed
  3. Dikeakos J, Atkins K, Thomas L, Emert Sedlak L, Byeon I, Jung J, et al. Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell. 2010;21:3279-92 pubmed publisher
    ..Together, these studies resolve the seemingly controversial models that describe Nef-induced MHC-I down-regulation and provide new insights into the mechanism of Nef action. ..
  4. Cheung L, Hennessy B, Li J, Yu S, Myers A, Djordjevic B, et al. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov. 2011;1:170-85 pubmed publisher
    ..PIK3R1 (p85?) mutations occur at a higher rate in endometrial cancer than in any other tumor lineage, and PIK3R2 (p85?), not previously demonstrated to be a cancer gene, is also frequently mutated...
  5. Rivière J, Mirzaa G, O Roak B, Beddaoui M, Alcantara D, Conway R, et al. De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat Genet. 2012;44:934-40 pubmed publisher
    ..These include 2 mutations in AKT3, 1 recurrent mutation in PIK3R2 in 11 unrelated families with MPPH and 15 mostly postzygotic mutations in PIK3CA in 23 individuals with MCAP and 1 ..
  6. Zhou F, Xue M, Qin D, Zhu X, Wang C, Zhu J, et al. HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3? signaling pathway. PLoS ONE. 2013;8:e53145 pubmed publisher
    ..Together, these results provide the first evidence that Tat might contribute to KS pathogenesis by synergizing with vIL-6, and identify PI3K/AKT pathway as a potential therapeutic target in AIDS-related KS patients. ..
  7. Borgatti P, Zauli G, Colamussi M, Gibellini D, Previati M, Cantley L, et al. Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. Eur J Immunol. 1997;27:2805-11 pubmed
    ..Taken together, these data suggest that the anti-apoptotic activity of low concentrations of Tat protein on Jurkat cells is mediated by a PI 3-kinase/Akt pathway. ..
  8. Chen G, Yang X, Yang X, Li L, Luo J, Dong H, et al. Jia-Wei-Jiao-Tai-Wan ameliorates type 2 diabetes by improving β cell function and reducing insulin resistance in diabetic rats. BMC Complement Altern Med. 2017;17:507 pubmed publisher
    ..expression, insulin receptor substrate (IRS) tyrosine phosphorylation, phosphatidylinositol 3-kinase (PI3K) (p85), and glucose transporter 4 (GLUT4) expression; and downregulated the serine phosphorylation of IRS...
  9. Wang L, Yin J, Wang X, Shao M, Duan F, Wu W, et al. C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits. Gastroenterology. 2016;150:1183-1195.e16 pubmed publisher
    ..Activation of CLEC2 in AGS cells reduced protein and messenger RNA levels of PI3K subunits p85 and p110; this effect was blocked by SYK inhibitor R406...
  10. Kwon H, Kim G, Lee Y, Jeong M, Kang I, Yang D, et al. Inhibition of platelet-derived growth factor receptor tyrosine kinase and downstream signaling pathways by Compound C. Cell Signal. 2013;25:883-97 pubmed publisher
    ..inhibited the receptor tyrosine phosphorylation and the activity of downstream signaling molecules, such as p85 phosphoinositide 3-kinase, phospholipase C-γ1, and extracellular signal-regulated kinase 1/2, induced by platelet-..
  11. Abdelmageed M, Shehatou G, Abdelsalam R, Suddek G, Salem H. Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction. Naunyn Schmiedebergs Arch Pharmacol. 2019;392:243-258 pubmed publisher
    ..in mRNA expression of insulin receptor substrate1 (IRS1), phosphatidylinositol 3-kinase regulatory subunit1 (PI3K-P85 subunit), and AKT serine/threonine kinase2 (AKT2); increased levels of P-AKT ser473 and aortic eNOS; and ..
  12. Liu Q, Li X, Li C, Zheng Y, Wang F, Li H, et al. 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice. Molecules. 2016;21:279 pubmed publisher
    ..Moreover, DNJ increased the phosphorylation of phosphatidylinositol 3 kinase (PI3K) on p85, protein kinase B (PKB) on Ser473, glycogen synthase kinase 3β (GSK-3β) on Ser9, and inhibited phosphorylation of ..
  13. Atikuzzaman M, Sanz L, Pla D, Alvarez Rodriguez M, Rubér M, Wright D, et al. Selection for higher fertility reflects in the seminal fluid proteome of modern domestic chicken. Comp Biochem Physiol Part D Genomics Proteomics. 2017;21:27-40 pubmed publisher
    ..factor IX, fibrinogen ?-chain, hemoglobin subunit ?-D, lysozyme C, phosphoglycerate kinase, Src-substrate protein p85, tubulins and thioredoxin were AIL-specific...
  14. Xie J, Jiang Y, Jiang Y, Li C, Lim M, An O, et al. Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma. Gastroenterology. 2018;154:2137-2151.e1 pubmed publisher
    ..LINC01503 disrupted the interaction between EBP1 and the p85 subunit of PI3K, increasing AKT signaling...
  15. Kuai M, Li Y, Sun X, Ma Z, Lin C, Jing Y, et al. A novel formula Sang-Tong-Jian improves glycometabolism and ameliorates insulin resistance by activating PI3K/AKT pathway in type 2 diabetic KKAy mice. Biomed Pharmacother. 2016;84:1585-1594 pubmed publisher
    ..Meanwhile, GLUT4 translocation and phosphorylation of IRS1, p85-PI3K and AKT were significantly increased by STJ treatments...
  16. Kim W, Noh H, Lee Y, Jeon J, Shanmugavadivu A, McPhie D, et al. MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons. Mol Neurobiol. 2016;53:95-108 pubmed publisher
    ..ERK signaling cascades, including AKT, GSK-3β, ERK, their phosphorylation, and the miR-126 targets IRS-1 and PIK3R2. Finally, inhibition of miR-126 was neuroprotective against both STS and Aβ1-42 toxicity...
  17. Li Q, Park K, Xia Y, Matsumoto M, Qi W, Fu J, et al. Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCδ Isoform Activation. Circ Res. 2017;121:1153-1167 pubmed publisher
    ..proteins, Akt and FoxO3a, with reduction of proapoptotic protein Bim associated with PKCδ induced inhibition of P85/PI3K...
  18. Hossen M, Baek K, Kim E, Yang W, Jeong D, Kim J, et al. In vivo and in vitro anti-inflammatory activities of Persicaria chinensis methanolic extract targeting Src/Syk/NF-κB. J Ethnopharmacol. 2015;159:9-16 pubmed publisher
    ..Phosphorylation of p85 and Akt induced by Src or Syk overexpression was blocked by Pc-ME...
  19. Yu W, Honisch S, Schmidt S, Yan J, Schmid E, Alkahtani S, et al. Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells. Cell Physiol Biochem. 2016;40:1141-1152 pubmed
    ..Chorein is effective in part by interacting with and fostering stimulation of phosphoinositide-3-kinase (PI3K)-p85-subunit. PI3K dependent signaling includes the serum and glucocorticoid inducible kinase SGK1...
  20. Hu S, Xu L, Shi D, Wang J, Wang Y, Lou Q, et al. Eicosapentaenoic acid-enriched phosphatidylcholine isolated from Cucumaria frondosa exhibits anti-hyperglycemic effects via activating phosphoinositide 3-kinase/protein kinase B signal pathway. J Biosci Bioeng. 2014;117:457-63 pubmed publisher
    ..remarkably enhanced the proteins abundance of IR-β, PI3K, PKB, GLUT4, as well as phosphorylation of Tyr-IR-β, p85-PI3K, Ser473-PKB (P < 0.05 and P < 0.01)...
  21. Chen J, Sun J, Doscas M, Ye J, Williamson A, Li Y, et al. Control of hyperglycemia in male mice by leflunomide: mechanisms of action. J Endocrinol. 2018;237:43-58 pubmed publisher
    ..A77 1726 increased insulin receptor tyrosine phosphorylation and binding of the p85 subunit of the PI-3 kinase to IRS-1...
  22. Jiang S, Li J, Dong F, Yang J, Liu D, Yang X, et al. Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice. Gastroenterology. 2017;153:277-291.e19 pubmed publisher
    ..5-HT stimulation led to formation of the HTR2B-LYN-p85 complex, which increased PI3K-Akt-mTOR signaling and the Warburg effect by increasing protein levels of MYC and ..
  23. Ohtake K, Nakano G, Ehara N, Sonoda K, Ito J, Uchida H, et al. Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKA(y) mice. Nitric Oxide. 2015;44:31-8 pubmed publisher
    ..the adipose tissue of KKA(y) diabetic mice, which also restored the insulin-mediated signal transduction, including p85 and Akt phosphorylation, and subsequently restored the GLUT4 expression in the skeletal muscles...
  24. Caramés B, Olmer M, Kiosses W, Lotz M. The relationship of autophagy defects to cartilage damage during joint aging in a mouse model. Arthritis Rheumatol. 2015;67:1568-76 pubmed publisher
    ..by a reduction in cartilage cellularity and an increase in the apoptosis marker poly(ADP-ribose) polymerase p85. Cartilage structural damage progressed in an age-dependent manner subsequent to the autophagy changes...
  25. Reho J, Shetty A, Dippold R, Mahurkar A, Fisher S. Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing. Physiol Rep. 2015;3: pubmed publisher
    ..Myosin phosphatase regulatory subunit paralogs Mypt1 and p85 were expressed at similar levels, while smooth muscle MLCK was the only such kinase expressed, suggesting ..
  26. Li Y, Chen X, Chen S, Wu J, Zhuo X, Zheng Q, et al. [A cohort study on the impacts of pre-pregnancy maternal body mass index, gestational weight gain on neonate birth status and perinatal outcomes in Fujian province]. Zhonghua Liu Xing Bing Xue Za Zhi. 2014;35:635-40 pubmed
    ..0. Similarly, when compared to pregnant women with normal GWG(defined as weight gain range from P15 to P85 by stratification of pre-pregnancy BMI), low GWG (<P15) seemed to be the risk factor for preterm birth, low ..
  27. Planas Rigol E, Terrades García N, Corbera Bellalta M, Lozano E, Alba M, Segarra M, et al. Endothelin-1 promotes vascular smooth muscle cell migration across the artery wall: a mechanism contributing to vascular remodelling and intimal hyperplasia in giant-cell arteritis. Ann Rheum Dis. 2017;76:1624-1634 pubmed publisher
    ..FAK activation resulted in Y397 autophosphorylation creating binding sites for Src kinases and the p85 subunit of PI3kinases which, upon ET-1 exposure, colocalised with FAK at the focal adhesions of migrating VSMC...
  28. Bhowmick S, D Mello V, Abdul Muneer P. Synergistic Inhibition of ERK1/2 and JNK, Not p38, Phosphorylation Ameliorates Neuronal Damages After Traumatic Brain Injury. Mol Neurobiol. 2019;56:1124-1136 pubmed publisher
    ..JNK phosphorylation in neurodegeneration by analyzing cell death proteins annexin V and Poly-ADP-Ribose-Polymerase p85. Interestingly, combined use of ERK1/2 and JNK inhibitors further attenuated the cell death in stretch-injured ..
  29. Borgatti P, Zauli G, Cantley L, Capitani S. Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. Biochem Biophys Res Commun. 1998;242:332-7 pubmed
    ..Taken together, these findings demonstrate that extracellular Tat shows a cytokine-like activity in PC12 cells, being able to trigger an intracellular signalling cascade which involves PKC-alpha, -epsilon, and -zeta. ..
  30. Mahajan V, Gaymalov Z, Alakhova D, Gupta R, Zucker I, Kabanov A. Horizontal gene transfer from macrophages to ischemic muscles upon delivery of naked DNA with Pluronic block copolymers. Biomaterials. 2016;75:58-70 pubmed publisher
    ..b>P85 enhanced (∼ 4 orders) transfection of MØs with pDNA in vitro...
  31. Drachsler M, Kleber S, Mateos A, Volk K, Mohr N, Chen S, et al. CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells. Cell Death Dis. 2016;7:e2209 pubmed publisher
    ..Recruitment of the activating PI3K subunit, p85, to CD95 death domain is required for maintenance of EMT-related transcripts...
  32. Cossío Bolaños M, Vasquez P, Luarte Rocha C, Sulla Torres J, Gómez Campos R. Assessment of self-perception of physical fitness and proposal for standards among Chilean adolescent students: the EAPAF study. Arch Argent Pediatr. 2016;114:319-28 pubmed publisher
    ..82 and 0.85. Percentiles (p15, p50 and p85) were developed to classify self-perception of physical fitness by dimension, age and sex...
  33. McCurdy C, Schenk S, Holliday M, Philp A, Houck J, Patsouris D, et al. Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes. 2012;61:2495-505 pubmed
    ..Global heterozygous deletion of the Pik3r1 regulatory subunits (αHZ), but not knockout of Pik3r2 (p85β), preserves whole-body, AT, and skeletal muscle insulin sensitivity, despite severe obesity...
  34. Kai lan W, Si Z. Pretreatment With Erythropoietin Attenuates Intestinal Ischemia Reperfusion Injury by Further Promoting PI3K/Akt Signaling Activation. Transplant Proc. 2015;47:1639-45 pubmed publisher
    ..TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ); and the protein levels of EPOR, p-EPOR, p85, p-p85, Akt, p-Akt, IκΒ-α, p-p65, and p65...
  35. Shim J, Kennedy R, Weatherly L, Hutchinson L, Pelletier J, Hashmi H, et al. Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events. J Appl Toxicol. 2016;36:1446-59 pubmed publisher
    ..Phospho-Syk and phospho-p85 phosphoinositide 3-kinase enzyme-linked immunosorbent assays data show that arsenic inhibits early phosphorylation ..
  36. Shepherd P, Nave B, Rincon J, Nolte L, Bevan A, Siddle K, et al. Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle. J Biol Chem. 1997;272:19000-7 pubmed
    ..The levels of p50 and p55(PIK) were not significantly changed. These properties indicate mechanisms by which specificity is achieved in the PI 3-kinase signaling system. ..
  37. Moutoussamy S, Renaudie F, Lago F, Kelly P, Finidori J. Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins. J Biol Chem. 1998;273:15906-12 pubmed
    ..With this probe, we identified Shc and the p85 subunit of phosphatidylinositol 3-kinase as direct targets of the receptor...
  38. Liu Q, Li X, Li C, Zheng Y, Peng G. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015;20:21700-14 pubmed publisher
    ..transporter 4 (GLUT4) in skeletal muscle were not affected, GLUT4 translocation and phosphorylation of Ser473-AKT, p85-PI3K, Tyr1361-IR-β and Tyr612-IRS1 were significantly increased by DNJ treatment...
  39. An Y, Feng H, Zhang X, Cong X, Zhao Q, Wu L, et al. Homocysteine ameliorates the endothelium-independent hypoxic vasoconstriction via the suppression of phosphatidylinositol 3-kinase/Akt pathway in porcine coronary arteries. Biochem Biophys Res Commun. 2017;486:178-183 pubmed publisher
    ..The protein levels of phosphorylated Akt at Ser473 and phosphorylated P85 at Tyr508 were decreased by Hcy in normoxia, and were also reduced exposure to hypoxia for 15 min and then ..
  40. August A, Dupont B. CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase. Int Immunol. 1994;6:769-74 pubmed
    ..Furthermore, a synthetic peptide representing the YM/VXM motif within the cytoplasmic tail of CD28 also interacts with PI3 kinase only when the tyrosine is phosphorylated.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  41. Lamers S, Fogel G, Singer E, Salemi M, Nolan D, Huysentruyt L, et al. HIV-1 Nef in macrophage-mediated disease pathogenesis. Int Rev Immunol. 2012;31:432-50 pubmed publisher
    ..Moreover, genetic variation in Nef may also guide the macrophage response. Herein, we review findings relating to the Nef-macrophage interaction and how this relationship contributes to disease pathogenesis. ..
  42. Saleh A, Soltani B, Dokanehiifard S, Medlej A, Tavalaei M, Mowla S. Experimental verification of a predicted novel microRNA located in human PIK3CA gene with a potential oncogenic function in colorectal cancer. Tumour Biol. 2016;37:14089-14101 pubmed
    ..In this pathway, PI3K? enzyme is composed of a regulatory protein encoded by p85 gene and a catalytic protein encoded by PIK3CA gene...
  43. Gershtein E, Shatskaya V, Ermilova V, Kushlinsky N, Krasil nikov M. Phospatidylinositol 3-kinase expression in human breast cancer. Clin Chim Acta. 1999;287:59-67 pubmed
    ..3-kinase (PI 3-kinase) expression was analysed by Western blotting with monoclonal antibodies to the p85 subunit in a series of tumour and adjacent mammary gland samples collected at surgery from 33 breast cancer ..
  44. Schibeci S, Clegg A, Biti R, Sagawa K, Stewart G, Williamson P. HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line. AIDS. 2000;14:1701-7 pubmed
    ..The results support a model in which Nef affects HIV disease progression by distorting T cell responses. ..
  45. Braunger J, Schleithoff L, Schulz A, Kessler H, Lammers R, Ullrich A, et al. Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. Oncogene. 1997;14:2619-31 pubmed
    ..Using different far-Western blot analyses and coimmunoprecipitation assays, receptor binding of PLCgamma and p85 proteins as well as GRB2, c-src and lck was examined in vitro and in vivo...
  46. Haidar M, Whitworth J, Noé G, Liu W, Vidal M, Langsley G. TGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages. Sci Rep. 2015;5:15688 pubmed publisher
    ..Using peptidimer-c to ablate SH2 and SH3 interactions of Grb2 we identify TGF-receptor II and the p85 subunit of PI3-K, as Grb2 partners in virulent macrophages...
  47. Kim E, Son Y, Yang Y, Shen T, Kim I, Aravinthan A, et al. 1-(2,3-Dibenzimidazol-2-ylpropyl)-2-methoxybenzene Is a Syk Inhibitor with Anti-Inflammatory Properties. Molecules. 2016;21:508 pubmed publisher
    ..inhibitor of κBα (IκBα), IκB kinase (IKK)α/β, Akt, 3-phosphoinositide dependent protein kinase-1 (PDK1), p85, and spleen tyrosine kinase (Syk)...
  48. Bulent Vatan M, Kalaycı Yigin A, Akdemir R, Tarik Agac M, Akif Cakar M, Aksoy M, et al. Altered Plasma MicroRNA Expression in Patients with Mitral Chordae Tendineae Rupture. J Heart Valve Dis. 2016;25:580-588 pubmed
    ..potential miRNA targets and pathways are commonly related to the development of MCTR: MMPs, TIMP-2,TGFBR2, VEGFA, PIK3R2, NRAS, PPP3CA, PPP3R1, PTGS 2 were predicted as putative targets of 13 of these miRNAs...
  49. Hosokawa K, Muranski P, Feng X, Keyvanfar K, Townsley D, Dumitriu B, et al. Identification of novel microRNA signatures linked to acquired aplastic anemia. Haematologica. 2015;100:1534-45 pubmed publisher
    ..05). In CD4(+) and CD8(+) T cells in aplastic anemia patients, MYC and PIK3R2 were up-regulated and proved to be targets of miR-145-5p and miR-126-3p, respectively...
  50. Ordoñez M, Rivera I, Presa N, Gomez Munoz A. Implication of matrix metalloproteinases 2 and 9 in ceramide 1-phosphate-stimulated macrophage migration. Cell Signal. 2016;28:1066-74 pubmed publisher
    ..regulated kinases 1-2 (ERK1-2) as demonstrated by treating the cells with specific siRNA to knockdown the p85 regulatory subunit of PI3K, or ERK1-2...
  51. Akhtar N, Khan N, Ashruf O, Haqqi T. Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis. Nutrition. 2017;33:1-13 pubmed publisher
    ..Expression of active caspase-3 and poly (ADP-ribose) polymerase p85 was determined by immunohistochemistry...
  52. Mellado M, Rodriguez Frade J, Vila Coro A, Fernandez S, Martín de Ana A, Jones D, et al. Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J. 2001;20:2497-507 pubmed
    ..These results show the effect of heterodimer formation on increasing the sensitivity and dynamic range of the chemokine response, and may aid in understanding the dynamics of leukocytes at limiting chemokine concentrations in vivo. ..
  53. Ylösmäki L, Schmotz C, Ylösmäki E, Saksela K. Reorganization of the host cell Crk(L)-PI3 kinase signaling complex by the influenza A virus NS1 protein. Virology. 2015;484:146-52 pubmed publisher
    The non-structural protein-1 (NS1) of influenza A virus binds the p85β subunit of phosphoinositide 3-kinase (PI3K) to induce PI3K activity in the infected cells...
  54. Kapeller R, Toker A, Cantley L, Carpenter C. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. J Biol Chem. 1995;270:25985-91 pubmed
    ..and Corvera, S. (1993) Mol. Cell. Biol. 13, 6052-6063). In complementary experiments we used the recombinant p85 subunit of PI 3-kinase to identify proteins that associate with phosphoinositide 3-kinase and found that ..
  55. Mazerolles F, Barbat C, Fischer A. Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. Eur J Immunol. 1997;27:2457-65 pubmed
    ..These results emphasize the role of PI3-kinase in the regulation of cytoskeleton structure. It is proposed that gp160 activates both p56lck and PI3-kinase which lead to a cytoskeleton organization unfavorable for LFA-1 function. ..
  56. Sossey Alaoui K, Li X, Ranalli T, Cowell J. WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase. J Biol Chem. 2005;280:21748-55 pubmed
    ..WAVE3 and the PI3K regulatory subunit, p85, were found to interact in a yeast two-hybrid screen, which was confirmed through co-immunoprecipitation...
  57. Han M, Ryu I, Lee J, Kim S, Chang H, Lee Y, et al. Phosphorylation of PI3K regulatory subunit p85 contributes to resistance against PI3K inhibitors in radioresistant head and neck cancer. Oral Oncol. 2018;78:56-63 pubmed publisher
    ..We found that PI3K regulatory subunit p85 was predominantly phosphorylated in radioresistant head and neck cancer cell line (HN31), which showed resistance ..
  58. Liu J, Liao Y, Ma K, Wang Y, Zhang G, Yang R, et al. PI3K is required for the physical interaction and functional inhibition of NF-?B by ?-catenin in colorectal cancer cells. Biochem Biophys Res Commun. 2013;434:760-6 pubmed publisher
    ..Mechanistically, the PI3K subunit p85 formed a complex with ?-catenin and NF-?B...
  59. Zhang M, Jang H, Gaponenko V, Nussinov R. Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains. Biophys J. 2017;113:1956-1967 pubmed publisher
    ..PI3Kα has two subunits: the regulatory p85 and the catalytic p110...
  60. Andreozzi F, Raciti G, Nigro C, Mannino G, Procopio T, Davalli A, et al. The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism. J Transl Med. 2016;14:229 pubmed publisher
    ..from insulin, EXE does not stimulate: (i) IR ?-subunit- and IRS1 tyrosine phosphorylation and binding to p85 regulatory subunit of PI-3kinase; (ii) AKT activation; and (iii) ERK1/2 and JNK1/2 phosphorylation...
  61. Borzi C, Calzolari L, Centonze G, Milione M, Sozzi G, Fortunato O. mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis. Int J Mol Sci. 2017;18: pubmed publisher
    ..a remarkable increase in mir-486-5p expression level and activity, detected as a reduction of its target gene, p85. mir-486-5p expression was confirmed by microRNA in situ hybridization...
  62. Wang H, Jin Y, Dai J. Biological processes and pathway changes in isoflurane-induced anesthesia revealed by bioinformatics analysis of gene expression profiles. J Anesth. 2015;29:912-9 pubmed publisher
    ..g., Pik3r1 and Pik3r2) in the constructed PPI network...
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    ..Activin, but not TGFβ, led to PI3K activation via interaction of ACVR1B and p85 independent of SMAD4, resulting in p21 downregulation...
  64. Cohran V, Managlia E, Bradford E, Goretsky T, Li T, Katzman R, et al. Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection. Am J Pathol. 2016;186:1837-1846 pubmed publisher
    ..Wild-type and epithelial Pik3r1 (p85?)-deficient mice underwent sham surgery or 30% resection...
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    ..At the signaling level, Gab3 co-precipitated with p85 and SHP2 in CRC cells, which was required for subsequent Akt and Erk activation...
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    ..These data show that Nef affects selectively the PI 3-kinase signaling pathway and suggest that this interference results in some of the HIV adverse effects on host cell functions. ..
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    ..In rat HTC hepatoma cells overexpressing normal human insulin receptors (HTC-IR), p85 regulatory subunit of phosphatidylinositol-3-kinase (PI3K) forms signaling complexes containing the insulin ..
  68. Lima Cabello E, Alché V, Foley R, Andrikopoulos S, Morahan G, Singh K, et al. Narrow-leafed lupin (Lupinus angustifolius L.) ?-conglutin proteins modulate the insulin signaling pathway as potential type 2 diabetes treatment and inflammatory-related disease amelioration. Mol Nutr Food Res. 2017;61: pubmed publisher
    ..mRNA and protein levels of genes important in insulin signaling pathways, namely insulin receptor substrate 1/p85/AKT/glucose transporter type 4...
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    ..Here we show that PTEN associates with p85, the regulatory subunit of PI3K...
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    ..This type of host-virus interaction has implications for anti-HIV therapeutics that target cellular signaling machinery. ..
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    ..Targeting these cellular signaling pathways may have benefit in controlling inflammatory sequelae of HIV infection such as in neurological disease. ..
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    ..trachomatis-induced cell survival and suggest that Tarp functions as a multivalent phosphorylation-dependent signaling hub that is important during the early phase of chlamydial infection. ..
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    ..vessels express high levels of miR-126, which primarily targets phosphoinositide-3-kinase regulatory subunit 2 (p85?)...
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    ..By inducing IDO, Tat protein may be considered, as a viral pathogenic factor, in the dysregulation of the DC functions during HIV-1 infection...
  76. Du C, Lv Z, Cao L, Ding C, Gyabaah O, Xie H, et al. MiR-126-3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2. J Transl Med. 2014;12:259 pubmed publisher
    ..LRP6 and PIK3R2 were identified as targets of miR-126-3p...
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    ..Whole-exome sequencing revealed a yet unreported de novo variant in the PIK3R2 gene that was recently associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndrome and ..
  78. Inaba S, Numoto N, Ogawa S, Morii H, Ikura T, Abe R, et al. Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins. J Biol Chem. 2017;292:1052-1060 pubmed publisher
    ..the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src homology 2 (SH2) ..
  79. Demirci S, Dogan A, Başak Türkmen N, Telci D, Cağlayan A, Beker M, et al. Poloxamer P85 increases anticancer activity of Schiff base against prostate cancer in vitro and in vivo. Anticancer Drugs. 2017;28:869-879 pubmed publisher
    ..In the current study, a novel heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used to evaluate anticancer activity against prostate cancer in vitro and in vivo...
  80. Wang L, Iorio C, Yan K, Yang H, Takeshita S, Kang S, et al. A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages. FASEB J. 2017;: pubmed publisher
    ..feedback by negatively regulating phosphorylation of M-CSF receptor at Tyr721 and, consequently, its binding to p85 subunit of PI3K and PI3K activation...
  81. Whitecross D, Anderson D. Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase. Sci Rep. 2017;7:16194 pubmed publisher
    ..The p85 subunit of phosphatidylinositol 3-kinase (PI3K) is a GTPase activating protein (GAP) towards Rab5...
  82. Uchida T, Myers M, White M. IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis. Mol Cell Biol. 2000;20:126-38 pubmed
    ..the activation of PKB/Akt and BAD phosphorylation during insulin stimulation; however, it weakly bound or activated p85-associated PI 3-kinase and failed to mediate the activation of p70(s6k)...
  83. Sathish J, Johnson K, Fuller K, LeRoy F, Meyaard L, Sims M, et al. Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells. J Immunol. 2001;166:1763-70 pubmed
    ..We propose that this mechanism may exert a constitutive negative regulatory role upon T cell signaling. ..
  84. Ong S, Hadari Y, Gotoh N, Guy G, Schlessinger J, Lax I. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A. 2001;98:6074-9 pubmed
  85. Martelli M, Boomer J, Bu M, Bierer B. T cell regulation of p62(dok) (Dok1) association with Crk-L. J Biol Chem. 2001;276:45654-61 pubmed
  86. Hafizi S, Alindri F, Karlsson R, Dahlback B. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. Biochem Biophys Res Commun. 2002;299:793-800 pubmed
    ..In summary, we have identified a novel multi-domain intracellular protein that interacts with Axl and which may furthermore be involved in other signal transduction pathways. ..
  87. Lu M, Zhang L, Sartippour M, Norris A, Brooks M. EG-1 interacts with c-Src and activates its signaling pathway. Int J Oncol. 2006;29:1013-8 pubmed
    ..Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation. ..
  88. Alcázar I, Cortes I, Zaballos A, Hernandez C, Fruman D, Barber D, et al. p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function. Blood. 2009;113:3198-208 pubmed publisher
  89. Wu H, Shekar S, Flinn R, El Sibai M, Jaiswal B, Sen K, et al. Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Proc Natl Acad Sci U S A. 2009;106:20258-63 pubmed publisher
    We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110alpha requires (i) an inhibitory contact between the p85 nSH2 domain and the p110alpha helical domain, and (ii) a contact between the p85 nSH2 and ..
  90. Kang Y, Digicaylioglu M, Russo R, Kaul M, Achim C, Fletcher L, et al. Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. Ann Neurol. 2010;68:342-52 pubmed publisher
    ..This combination peptide therapy should therefore be tested in humans with HAND. ..
  91. Schauder C, Ma L, Krug R, Montelione G, Guan R. Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1567-71 pubmed publisher
    ..These proteins have multiple isoforms and consist of a catalytic p110 subunit and a regulatory p85 subunit...
  92. Shah A, Silverstein P, Kumar S, Singh D, Kumar A. Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. PLoS ONE. 2012;7:e52060 pubmed publisher
    ..This study therefore provides novel information regarding the interaction between MA and gp120 in terms of the expression of IL-6 and the mechanisms underlying potential synergy between MA and gp120 in astrocytes...