PIK3CG

Summary

Gene Symbol: PIK3CG
Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Alias: PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-phosphatidylinositol 3-kinase, PI3-kinase subunit gamma, phosphatidylinositol 3 kinase gamma, p110 gamma, phosphatidylinositol 3-kinase catalytic 110-kD gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphoinositide-3-kinase gamma catalytic subunit, ptdIns-3-kinase subunit gamma, ptdIns-3-kinase subunit p110-gamma, serine/threonine protein kinase PIK3CG
Species: human
Products:     PIK3CG

Top Publications

  1. Inoue T, Meyer T. Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS ONE. 2008;3:e3068 pubmed publisher
    Phosphatidylinositol 3-OH kinase (PI3K) has been widely studied as a principal regulator of cell polarization, migration, and chemotaxis...
  2. Chen X, Cheng L, Jia X, Zeng Y, Yao S, Lv Z, et al. Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice. Neoplasia. 2009;11:1272-84 pubmed
  3. Pacold M, Suire S, Perisic O, Lara Gonzalez S, Davis C, Walker E, et al. Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell. 2000;103:931-43 pubmed
    Ras activation of phosphoinositide 3-kinase (PI3K) is important for survival of transformed cells. We find that PI3Kgamma is strongly and directly activated by H-Ras G12V in vivo or by GTPgammaS-loaded H-Ras in vitro...
  4. Swann S, Williams M, Story C, Bobbitt K, Fleis R, Collins K. HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway. Virology. 2001;282:267-77 pubmed
    ..We propose that Nef diverts MHC-1 proteins into a PI 3-kinase-dependent transport pathway that prevents expression on the cell surface. ..
  5. Bis J, Kavousi M, Franceschini N, Isaacs A, Abecasis G, Schminke U, et al. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet. 2011;43:940-7 pubmed publisher
    ..006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events. ..
  6. Lee D, Szczepanski M, Lee Y. Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. J Cell Biochem. 2009;106:1113-22 pubmed publisher
    ..These results suggest that one of the mechanisms of the apoptotic activity of magnolol involves its effect on epidermal growth factor receptor (EGFR)-mediated signaling transduction pathways. ..
  7. Lim K, Counter C. Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. Cancer Cell. 2005;8:381-92 pubmed
    ..We now show in human cells that the Ras effector pathways MAPK, RalGEF, and PI3K are required to initiate tumor growth...
  8. Zhang S, Yu D. PI(3)king apart PTEN's role in cancer. Clin Cancer Res. 2010;16:4325-30 pubmed publisher
    ..phosphatase, counteracting one of the most critical cancer-promoting pathways: the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway...
  9. Lee C, Liu Q, Tomkowicz B, Yi Y, Freedman B, Collman R. Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. J Leukoc Biol. 2003;74:676-82 pubmed
    ..Targeting these cellular signaling pathways may have benefit in controlling inflammatory sequelae of HIV infection such as in neurological disease. ..

More Information

Publications91

  1. Kasper M, Collins K. Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells. J Virol. 2003;77:3041-9 pubmed
  2. Blagoveshchenskaya A, Thomas L, Feliciangeli S, Hung C, Thomas G. HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell. 2002;111:853-66 pubmed
    ..Here, we show that Nef and PACS-1 combine to usurp the ARF6 endocytic pathway by a PI3K-dependent process and downregulate cell surface MHC-I to the TGN...
  3. Deregibus M, Cantaluppi V, Doublier S, Brizzi M, Deambrosis I, Albini A, et al. HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. J Biol Chem. 2002;277:25195-202 pubmed
  4. Naga Prasad S, Barak L, Rapacciuolo A, Caron M, Rockman H. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. J Biol Chem. 2001;276:18953-9 pubmed
  5. Krugmann S, Hawkins P, Pryer N, Braselmann S. Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. J Biol Chem. 1999;274:17152-8 pubmed
    ..The enzyme comprises a p110gamma catalytic subunit and a p101 regulatory subunit...
  6. Leopoldt D, Hanck T, Exner T, Maier U, Wetzker R, Nurnberg B. Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit. J Biol Chem. 1998;273:7024-9 pubmed
    ..This study examines the direct interaction of purified recombinant PI3Kgamma catalytic subunit (p110gamma) and Gbetagamma complexes...
  7. Borgatti P, Zauli G, Colamussi M, Gibellini D, Previati M, Cantley L, et al. Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. Eur J Immunol. 1997;27:2805-11 pubmed
    ..Taken together, these data suggest that the anti-apoptotic activity of low concentrations of Tat protein on Jurkat cells is mediated by a PI 3-kinase/Akt pathway. ..
  8. Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, et al. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science. 1995;269:690-3 pubmed
    ..The p110 gamma isotype may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers phosphorylated in the D-3 position. ..
  9. Martin D, Galisteo R, Molinolo A, Wetzker R, Hirsch E, Gutkind J. PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell. 2011;19:805-13 pubmed publisher
    ..We found that PI3Kγ, a PI3K isoform exhibiting restricted tissue distribution, is strictly required for signaling from the KSHV-..
  10. Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani J, et al. PI3K? within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proc Natl Acad Sci U S A. 2011;108:E854-63 pubmed publisher
    ..The lipid kinase PI3K? is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell ..
  11. Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie G, et al. Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell. 2011;42:84-95 pubmed publisher
    ..Pharmacological inhibition of p110γ normalizes β-adrenergic receptor density and improves contractility in failing hearts. ..
  12. Shymanets A, Ahmadian M, Kössmeier K, Wetzker R, Harteneck C, Nurnberg B. The p101 subunit of PI3K? restores activation by G? mutants deficient in stimulating p110?. Biochem J. 2012;441:851-8 pubmed publisher
    G-protein-regulated PI3K? (phosphoinositide 3-kinase ?) plays a crucial role in inflammatory and allergic processes...
  13. Johnson A, Yanek L, Chen M, Faraday N, Larson M, Tofler G, et al. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet. 2010;42:608-13 pubmed publisher
    ..6x10(-13)), PEAR1 (P=3.4x10(-12)), ADRA2A (P=3.3x10(-11)), PIK3CG (P=3.1x10(-9)), JMJD1C (P=1.6x10(-8)), MRVI1 (P=2.0x10(-8)) and SHH (P=4.5x10(-8))...
  14. Zhou F, Xue M, Qin D, Zhu X, Wang C, Zhu J, et al. HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3? signaling pathway. PLoS ONE. 2013;8:e53145 pubmed publisher
    ..Mechanistic studies indicated Tat activates PI3K and AKT, and inactivates PTEN and GSK-3? in vIL-6 expressing cells...
  15. Ferguson G, Milne L, Kulkarni S, Sasaki T, Walker S, Andrews S, et al. PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol. 2007;9:86-91 pubmed
  16. Metjian A, Roll R, Ma A, Abrams C. Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. J Biol Chem. 1999;274:27943-7 pubmed
    ..Of the four isoforms of human PI3K that phosphorylate phosphatidylinositol 4, 5-bisphosphate, only p110gamma (or PI3Kgamma) is associated with the regulatory subunit, p101, and is stimulated by G protein betagamma heterodimers...
  17. Walker E, Perisic O, Ried C, Stephens L, Williams R. Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature. 1999;402:313-20 pubmed
    ..Here we report the 2.2 A X-ray crystallographic structure of the catalytic subunit of PI3Kgamma, the class I enzyme that is activated by heterotrimeric G-protein betagamma subunits and Ras...
  18. Naccache P, Levasseur S, Lachance G, Chakravarti S, Bourgoin S, McColl S. Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma. J Biol Chem. 2000;275:23636-41 pubmed
    ..were to determine whether the newly described, G protein-dependent phosphatidylinositol 3-kinase (PI3K), p110gamma, was involved in the responses to chemotactic factors interacting with G protein-coupled receptors...
  19. Brock C, Schaefer M, Reusch H, Czupalla C, Michalke M, Spicher K, et al. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. J Cell Biol. 2003;160:89-99 pubmed
    Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P2 to PtdIns-3,4,5-P3...
  20. Sade H, Krishna S, Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J Biol Chem. 2004;279:2937-44 pubmed
    ..inhibitors and dominant-negative approaches, we describe a functional role for phosphatidylinositol 3-kinase (PI3K)-dependent activation of the serine-threonine kinase Akt/PKB in the regulation of AcN1-mediated anti-apoptotic ..
  21. Suire S, Coadwell J, Ferguson G, Davidson K, Hawkins P, Stephens L. p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. Curr Biol. 2005;15:566-70 pubmed
    ..PI3Kgamma is currently thought to be composed of a p110gamma catalytic subunit and a single regulatory subunit, p101...
  22. Abe M, Sogabe Y, Syuto T, Yokoyama Y, Ishikawa O. Evidence that PI3K, Rac, Rho, and Rho kinase are involved in basic fibroblast growth factor-stimulated fibroblast-Collagen matrix contraction. J Cell Biochem. 2007;102:1290-9 pubmed
    ..Three different inhibitors, LY294002 for phosphatidylinositol-3-kinase (PI3K), C3 exotransferase for Rho and Y27632 for Rho kinase, suppressed the bFGF-stimulated fibroblast-collagen matrix ..
  23. Francois F, Klotman M. Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. J Virol. 2003;77:2539-49 pubmed
    ..This type of host-virus interaction has implications for anti-HIV therapeutics that target cellular signaling machinery. ..
  24. Chugh P, Fan S, Planelles V, Maggirwar S, Dewhurst S, Kim B. Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. J Mol Biol. 2007;366:67-81 pubmed
    ..showed that the pro-survival effects of intracellular Tat could be attributed to activation of the PI-3-kinase (PI3K)/Akt pathway in the microglial cell line...
  25. Chen L, Song T, Xiao J, Huang Z, Li Y, Lin T. Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells. Oncotarget. 2017;8:63911-63922 pubmed publisher
    ..These results indicate that T4 induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway...
  26. Unver N, Delgado O, Zeleke K, Cumpian A, Tang X, Caetano M, et al. Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol. Int J Cancer. 2017;: pubmed publisher
    ..myo-inositol has previously been reported to inhibit phosphoinositide 3-kinase (PI3K) signaling. However, in mice raised on myo-inositol, total PI3K signaling was largely unaffected...
  27. Jiang W, Guo M, Gong M, Chen L, Bi Y, Zhang Y, et al. Vitamin A bio-modulates apoptosis via the mitochondrial pathway after hypoxic-ischemic brain damage. Mol Brain. 2018;11:14 pubmed publisher
    ..The protein and mRNA levels of RARα, PI3K, Akt, Bad, caspase-3, caspase-8, Bcl-2, Bax, and Bid were measured with western blotting and real-time PCR, ..
  28. Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed publisher
    ..The CK1α-dependent phosphoregulation of FOXO4 is primed, in part, by the PI3K/AKT effector axis of oncogenic RAS signalling...
  29. Freudenblum J, Iglesias J, Hermann M, Walsen T, Wilfinger A, Meyer D, et al. In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis. Development. 2018;145: pubmed publisher
    ..morphology and cell dynamics, we determined that endocrine cell motility is regulated by phosphoinositide 3-kinase (PI3K) and G-protein-coupled receptor (GPCR) signaling...
  30. Khaodee W, Inboot N, Udomsom S, Kumsaiyai W, Cressey R. Glucosidase II beta subunit (GluII?) plays a role in autophagy and apoptosis regulation in lung carcinoma cells in a p53-dependent manner. Cell Oncol (Dordr). 2017;40:579-591 pubmed publisher
    ..We also found that GluII? inhibition dose-dependently decreased activation of the EGFR/RTK and PI3K/AKT signaling pathways...
  31. Huang Z, Miao X, Patarroyo M, Nilsson G, Pernow J, Li N. Tetraspanin CD151 and integrin α6β1 mediate platelet-enhanced endothelial colony forming cell angiogenesis. J Thromb Haemost. 2016;14:606-18 pubmed publisher
    ..Moreover, platelets exerted the enhancement via the Src-PI3K signaling pathway of ECFCs...
  32. Fang R, Zhang L, Zhang L, Li W, Li M, Wen K. Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3? Phosphorylation. Arch Med Res. 2017;48:147-155 pubmed publisher
    ..Moreover, the protective effects of S1P treatment were blocked by cotreatment with a PI3K inhibitor, LY294002...
  33. Hu Y, Lu J, Xu X, Lyu J, Zhang H. Regulation of focal adhesion turnover in SDF-1α-stimulated migration of mesenchymal stem cells in neural differentiation. Sci Rep. 2017;7:10013 pubmed publisher
    ..Further, we confirm that PI3K/Akt and MAPK pathways participate in the regulation of SDF-1α-induced cell migration and FA assembly, and moreover,..
  34. Pang Y, Thomas P. Additive effects of low concentrations of estradiol-17? and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways. J Steroid Biochem Mol Biol. 2017;165:258-267 pubmed publisher
    ..Pre-treatment with inhibitors of PI3K (wortmannin), Akt (ML-9), and MAP kinase (AZD6244 and U0126) completely blocked the NO response to 5nM P4+E2...
  35. Wen X, Ma H, Zhao L, Zhang W, Dang C. MiR-30a suppresses non-small cell lung cancer progression through AKT signaling pathway by targeting IGF1R. Cell Mol Biol (Noisy-le-grand). 2015;61:78-85 pubmed
    ..in NSCLC cells, which included suppressed NSCLC cell proliferation and trigering cell cycle arrest through PI3K/AKT signaling pathway by inhibiting cell cycle regulators (CDK2, CDK4, Cyclin A2 , Cyclin D1)...
  36. Zhang Y, Hu M, Meng F, Sun X, Xu H, Zhang J, et al. Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome. EBioMedicine. 2017;18:157-170 pubmed publisher
    ..In contrast to glucose transport, uterine inflammatory gene expression was suppressed through the PI3K-Akt-NF?B network, but without affecting apoptosis...
  37. Bell B, Harlan S, Morgan D, Guo D, Cui H, Rahmouni K. Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin. Mol Metab. 2018;8:1-12 pubmed publisher
    ..We also studied mice lacking the catalytic p110α or p110β subunits of phosphatidylinositol-3 kinase (PI3K) in POMC neurons...
  38. Wehrenberg Klee E, Turker N, Heidari P, Larimer B, Juric D, Baselga J, et al. Differential Receptor Tyrosine Kinase PET Imaging for Therapeutic Guidance. J Nucl Med. 2016;57:1413-9 pubmed publisher
    Inhibitors of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway hold promise for the treatment of breast cancer, but resistance to these treatments can arise via feedback loops that ..
  39. Bhowmik T, Gomes A. NKCT1 (purified Naja kaouthia protein toxin) conjugated gold nanoparticles induced Akt/mTOR inactivation mediated autophagic and caspase 3 activated apoptotic cell death in leukemic cell. Toxicon. 2016;121:86-97 pubmed publisher
    ..GNP-NKCT1 induced autophagic pathway was detected through Akt, mTOR and PI3K expression by western blotting...
  40. Chen J, Zhan L, Lu X, Xiao C, Sun N. The Alteration of ZiBuPiYin Recipe on Proteomic Profiling of Forebrain Postsynaptic Density of db/db Mice with Diabetes-Associated Cognitive Decline. J Alzheimers Dis. 2017;56:471-489 pubmed publisher
    ..Notably, we found 'Protein processing in endoplasmic reticulum' and 'PI3K-Akt signaling pathway' might be impaired in DACD pathogenesis, while Growth factor receptor-bound protein 2 might ..
  41. Sarkar I, Garg R, van Drunen Littel van den Hurk S. The respiratory syncytial virus fusion protein formulated with a polymer-based adjuvant induces multiple signaling pathways in macrophages. Vaccine. 2018;36:2326-2336 pubmed publisher
    ..Based on inhibition studies at both transcript and protein levels, JNK, ERK1/2, CaMKII, PI3K and JAK pathways were clearly responsible for ?F/TriAdj-mediated chemokine and pro-inflammatory cytokine responses, ..
  42. Wang W, Yin L, Bai L, Ma G, Zhao C, Xiang A, et al. Bmal1 interference impairs hormone synthesis and promotes apoptosis in porcine granulosa cells. Theriogenology. 2017;99:63-68 pubmed publisher
    ..Western blot analysis showed that Bmal1 interference inactivated the PI3K/Akt/mTOR signaling pathway...
  43. Kim A, Seong K, Kang H, Park S, Lee S. Inhibition of Lyn is a promising treatment for mantle cell lymphoma with bortezomib resistance. Oncotarget. 2015;6:38225-38 pubmed publisher
    ..BCR signaling pathway enhanced the activity of Src family kinases (SFKs), especially Lyn, and downstream kinases PI3K/AKT/mTOR in BTZ-resistant MCL cells...
  44. Zhuo M, Luo Z, Xu Y, Li D, Pan Y, Wu K. Functional Analysis of Promoters from Three Subtypes of the PI3K Family and Their Roles in the Regulation of Lipid Metabolism by Insulin in Yellow Catfish Pelteobagrus fulvidraco. Int J Mol Sci. 2018;19: pubmed publisher
    In the present study, the length of 360, 1848 and 367 bp sequences of promoters from three subtypes of PI3K family (PI3KCa, PI3KC2b and PI3KC3) of yellow catfish Pelteobagrus fulvidraco were cloned and characterized...
  45. Reuschenbach M, Wagner S, Würdemann N, Sharma S, Prigge E, Sauer M, et al. [Human papillomavirus and squamous cell cancer of the head and neck region : Prognostic, therapeutic and prophylactic implications]. HNO. 2016;64:450-9 pubmed publisher
    ..These may be inhibitors of the phosphatidylinositol 3‑kinase (PI3K) pathway, which is frequently activated in HPV-associated OPSCC, and immunotherapeutic methods, e. g...
  46. Mármol I, Sánchez de Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi M. Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. Int J Mol Sci. 2017;18: pubmed publisher
    ..common mutations, chromosomal changes and translocations have been reported to affect important pathways (WNT, MAPK/PI3K, TGF-?, TP53), and mutations; in particular, genes such as c-MYC, KRAS, BRAF, PIK3CA, PTEN
  47. Zhou L, Chen H, Mao X, Qi H, Baker P, Zhang H. G-protein-coupled receptor 30 mediates the effects of estrogen on endothelial cell tube formation in vitro. Int J Mol Med. 2017;39:1461-1467 pubmed publisher
    ..The activation of eNOS was inhibited by wortmannin, an inhibitor of PI3K/Akt. Our data thus demonstrate that estrogen prevents the failure of endothelial cell tube formation induced by H/R...
  48. Üstün S, Lassnig C, Preitschopf A, Mikula M, Muller M, Hengstschlager M, et al. Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transpl Immunol. 2015;33:45-50 pubmed publisher
    ..Therefore, we tested the effects of the mTOR inhibitor everolimus and the novel dual PI3K/mTOR inhibitor NVP-BEZ235 in a murine lipopolysaccharide (LPS)-induced acute lung injury model...
  49. Xie Q, Wen H, Zhang Q, Zhou W, Lin X, Xie D, et al. Inhibiting PI3K-AKt signaling pathway is involved in antitumor effects of ginsenoside Rg3 in lung cancer cell. Biomed Pharmacother. 2017;85:16-21 pubmed publisher
    ..In this study, the effects of ginsenoside Rg3 on cells viability, apoptosis and PI3K/Akt signaling pathway in lung cancer cells were investigated in vitro and in vivo...
  50. Takata K, Imaizumi S, Kawachi E, Yahiro E, Suematsu Y, Shimizu T, et al. The ApoA-I mimetic peptide FAMP promotes recovery from hindlimb ischemia through a nitric oxide (NO)-related pathway. Int J Cardiol. 2016;207:317-25 pubmed publisher
    ..LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), significantly inhibited the activation of eNOS by FAMP...
  51. Zhang W, Zheng J, Meng J, Neng L, Chen X, Qin Z. Macrophage migration inhibitory factor mediates viability and apoptosis of PVM/Ms through PI3K/Akt pathway. Neuroscience. 2017;360:220-229 pubmed publisher
    ..Moreover, MIF effectively altered the expression levels of CDK1, BRAF, p-ERK1/2, p-PI3K, and p-Akt...
  52. Xu D, Toyoda H, Yuan X, Qi L, Chelakkot V, Morimoto M, et al. Anti-tumor effect of AZD8055 against neuroblastoma cells in vitro and in vivo. Exp Cell Res. 2018;365:177-184 pubmed publisher
    ..High-risk NB remains lethal in about 50% of patients despite comprehensive and intensive treatments. Activation of PI3K/Akt/mTOR signaling pathway correlates with oncogenesis, poor prognosis and chemotherapy resistance in NB...
  53. Chang C, Wu S, Chang C, Lin C, Kwan A. Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model. Biomed Res Int. 2015;2015:490209 pubmed publisher
    ..Basilar arteries (BAs) were obtained to examine phosphatidylinositol-3-kinase (PI3K), phospho-PI3K, Akt, phospho-Akt (Western blot) and morphological examination...
  54. Mafficini A, Amato E, Cataldo I, Rusev B, Bertoncello L, Corbo V, et al. Ampulla of Vater Carcinoma: Sequencing Analysis Identifies TP53 Status as a Novel Independent Prognostic Factor and Potentially Actionable ERBB, PI3K, and WNT Pathways Gene Mutations. Ann Surg. 2016;: pubmed
    ..we evaluated mutations in 16 key components of rat sarcoma (RAS), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), protein 53 (P53), transforming growth factor beta (TGF-?), and wingless/integrated (WNT) pathways, recently ..
  55. Wahl M, Chang S, Phillips J, Molinaro A, Costello J, Mazor T, et al. Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. Cancer. 2017;123:4631-4639 pubmed publisher
    Activation of the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is common in patients with low-grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been ..
  56. Osaki M, Kase S, Adachi K, Takeda A, Hashimoto K, Ito H. Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. J Cancer Res Clin Oncol. 2004;130:8-14 pubmed
    ..We concluded that: 1) the PI3K-Akt pathway plays an important role in preventing Fas-mediated apoptosis; and 2) a PI3 K inhibitor, such as ..
  57. de Souza D, Salles L, Camargo R, Gulart L, Costa E Silva S, de Lima B, et al. Effects of PI3K and FSH on steroidogenesis, viability and embryo development of the cumulus-oocyte complex after in vitro culture. Zygote. 2018;26:50-61 pubmed publisher
    The purpose of this study was to evaluate the effects of FSH and PI3K on the nuclear maturation, viability, steroidogenesis and embryo development of bovine cumulus-oocyte complexes (COCs)...
  58. Klebanoff C, Crompton J, Leonardi A, Yamamoto T, Chandran S, Eil R, et al. Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy. JCI Insight. 2017;2: pubmed publisher
    ..Thus, inhibition of signaling along the PI3K/AKT axis represents a generalizable strategy to generate large numbers of receptor-modified T cells with an early ..
  59. Lee H, Zarza X, Kim J, Yoon M, Kim S, Lee J, et al. Vacuolar Trafficking Protein VPS38 Is Dispensable for Autophagy. Plant Physiol. 2018;176:1559-1572 pubmed publisher
    ..Vacuolar protein sorting 34 (Vps34) is a conserved PI3K present in multiple complexes with specific functions and regulation...
  60. Colabufo N, Contino M, Niso M, Berardi F, Leopoldo M, Perrone R. EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives. Front Biosci (Landmark Ed). 2011;16:1811-23 pubmed
    ..kinase domain (18 to 21) and truncating mutations (exons 2 to 7) that involve downstream effectors such as MAPK, PI3K/Akt, STAT...
  61. Gill B, Navgeet -, Mehra R, Kumar V, Kumar S. Ganoderic acid, lanostanoid triterpene: a key player in apoptosis. Invest New Drugs. 2018;36:136-143 pubmed publisher
    ..It primarily targets NF-κB, RAS-MAPK, PI3K/Akt/mTOR, and cell cycle resulting in apoptosis...
  62. Ahn K, Choi E, Kwon D, Hwangbo H, Kim M, Kim H, et al. Induction of apoptosis by ethanol extract of Citrus unshiu Markovich peel in human bladder cancer T24 cells through ROS-mediated inactivation of the PI3K/Akt pathway. Biosci Trends. 2017;11:565-573 pubmed publisher
    ..In addition, EECU inactivated phosphatidylinositol 3-kinase (PI3K) as well as Akt, a downstream molecular target of PI3K, and LY294002, a specific PI3K inhibitor significantly ..
  63. Yin H, Wang H, Zhang H, Gao N, Zhang T, Yang Z. Resveratrol Attenuates A?-Induced Early Hippocampal Neuron Excitability Impairment via Recovery of Function of Potassium Channels. Neurotox Res. 2017;32:311-324 pubmed publisher
    ..was also found that resveratrol could decline the increase of protein kinase A (PKA) and inhibit the activation of PI3K/Akt signaling pathway induced by A?25-35...
  64. Van Swearingen A, Sambade M, Siegel M, Sud S, McNeill R, Bevill S, et al. Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer. Neuro Oncol. 2017;19:1481-1493 pubmed publisher
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    ..Secretory activity of monocytes is regulated mainly by PI3K improving cell resistance to disturbances...
  66. Tonlaar N, Galoforo S, Thibodeau B, Ahmed S, Wilson T, Yumpo Cardenas P, et al. Antitumor activity of the dual PI3K/MTOR inhibitor, PF-04691502, in combination with radiation in head and neck cancer. Radiother Oncol. 2017;124:504-512 pubmed publisher
    ..The PI3K/AKT/MTOR pathway has been identified from several next generation DNA sequencing studies to be commonly altered and ..
  67. Ryu M, Nogami A, Kitakaze T, Harada N, Suzuki Y, Yamaji R. Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts. Cell Biol Int. 2017;41:1325-1334 pubmed publisher
    ..As expected, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the MAPK inhibitor U0126 inhibited Lf-induced phosphorylation of Akt1 and ERK1/2, ..
  68. Gu Z, Zhang Z, Wang J, Xu B. Icariin exerts inhibitory effects on the growth and metastasis of KYSE70 human esophageal carcinoma cells via PI3K/AKT and STAT3 pathways. Environ Toxicol Pharmacol. 2017;54:7-13 pubmed publisher
    ..Results also indicated that icariin reduced cell viability and migration in part through suppression of the PI3K/AKT and STAT3 pathways...
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    ..At early developmental stages, physiologically high PI3K-Akt-mTORC1 signaling suppresses expression of Krox20 (Egr2), the master regulator of PNS myelination...
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    ..resulting from heterozygous mutations in PIK3R1 encoding a regulatory subunit of phosphoinositide-3-kinase (PI3K)...
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    Phosphoinositide 3-kinases (PI3Ks) are major regulators of many cellular functions, and hyperactivation of PI3K cell signalling pathways is a major target for anticancer drug discovery...
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    ..UNBS5162 downregulated the protein expression of proteins associated with the phosphatidylinositol 3‑kinase (PI3K)/AKT signaling pathway, including the levels of phosphorylated (p)‑AKT, p‑mechanistic target of rapamycin ..
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    ..of Wnt/?-catenin signaling in RGC protect from glaucomatous axonal damage via IGF-1 causing increased activity of PI3K-Akt signaling...
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    ..virus (WNV) has been shown to activate several signaling pathways such as endoplasmic reticulum (ER)-stress and AKT/PI3K pathway, resulting in activation or suppression of apoptosis in virus-infected cells...
  75. Spadari R, Cavadas C, de Carvalho A, Ortolani D, de Moura A, Vassalo P. Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. Cell Mol Neurobiol. 2018;38:109-120 pubmed publisher
    ..of the Gs protein on cyclic adenosine monophosphate production and activates the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway...
  76. Riquelme S, Hopkins B, Wolfe A, Dimango E, Kitur K, Parsons R, et al. Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity. Immunity. 2017;47:1169-1181.e7 pubmed publisher
    The tumor suppressor PTEN controls cell proliferation by regulating phosphatidylinositol-3-kinase (PI3K) activity, but the participation of PTEN in host defense against bacterial infection is less well understood...
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    ..metformin on UA-induced insulin resistance was monitored by adding Compound C, an AMPK inhibitor, and LY294002, a PI3K/AKT inhibitor...
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    ..Fourth, examine the contribution of the PI3K-Akt signaling pathway as a mechanism underlying increased BRB permeability. Young adult rats were given water, 0...
  79. Wu Y, Yoder A. Chemokine coreceptor signaling in HIV-1 infection and pathogenesis. PLoS Pathog. 2009;5:e1000520 pubmed publisher
    ..In this review, we summarize past and present studies on HIV coreceptor signaling. We also discuss possible roles of coreceptor signaling in facilitating viral infection and pathogenesis. ..
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    ..The activation of PI3K and MAPK pathways also participates in the leptin expression...
  81. Li H, Wang R. Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway. Life Sci. 2017;190:84-90 pubmed publisher
    ..SIRT1 has been shown to have a neuroprotective effect; however, its working mechanisms are not well understood. This study aimed to address this issue...
  82. Kamal A, Lakshma Nayak V, Nagesh N, Vishnuvardhan M, Subba Reddy N. Benzo[b]furan derivatives induces apoptosis by targeting the PI3K/Akt/mTOR signaling pathway in human breast cancer cells. Bioorg Chem. 2016;66:124-31 pubmed publisher
    The PI3K/Akt/mTOR signaling pathway plays a key regulatory function in cell survival, proliferation, migration, metabolism and apoptosis...