Genomes and Genes
Gene Symbol: PIGO
Description: phosphatidylinositol glycan anchor biosynthesis, class O
Alias: HPMRS2, GPI ethanolamine phosphate transferase 3, phosphatidylinositol-glycan biosynthesis class O protein
- Filtering for compound heterozygous sequence variants in non-consanguineous pedigreesTom Kamphans
Smart Algos, Berlin, Germany
PLoS ONE 8:e70151. 2013..of four family members, two sisters affected by Mabry syndrome and their healthy parents, the disease-causing gene PIGO, which harbors the pathogenic compound heterozygous variants, could be readily identified...
- PGAP2 mutations, affecting the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation syndromePeter M Krawitz
Institute for Medical Genetics and Human Genetics, Charite Universitatsmedizin, 13353 Berlin, Germany
Am J Hum Genet 92:584-9. 2013..To date, mutations have been identified in six genes (PIGA, PIGL, PIGM, PIGN, PIGO, and PIGV) encoding proteins in the GPI-anchor-synthesis pathway in individuals with severe neurological features, ..
- Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disabilityLars Hansen
Wilhelm Johannsen Centre for Functional Genome Research, The Panum Institute, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
Am J Hum Genet 92:575-83. 2013..Germline mutations in six genes (PIGA, PIGL, PIGM, PIGV, PIGN, and PIGO) in the ER-located part of the GPI-anchor-biosynthesis pathway have been reported, and all are associated with ..
- Mutations in PIGO, a member of the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardationPeter M Krawitz
Institute for Medical Genetics and Human Genetics, Charite Universitatsmedizin, Berlin, Germany
Am J Hum Genet 91:146-51. 2012..By exome sequencing, we detected compound-heterozygous mutations in PIGO, a gene coding for a membrane protein of the same molecular pathway, in two siblings with HPMRS, and we then found ..
- Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell systemJun Nakamura
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 7:e33563. 2012..This novel assay for DT40 cells provides a valuable tool to investigate the mode of action of mutations caused by reactive agents using a series of isogenic mutant DT40 cells...
- Phenytoin-induced gingival overgrowthR Arya
Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
Acta Neurol Scand 125:149-55. 2012..Poor periodontal hygiene is an important risk factor for severity of Phenytoin-induced gingival overgrowth (PIGO), which is a time-dependent process...
- Folic acid supplementation prevents phenytoin-induced gingival overgrowth in childrenR Arya
Division of Pediatric Neurology, AIIMS, Ansari Nagar, New Delhi 110 029, India
Neurology 76:1338-43. 2011..This study aimed to evaluate the effect of oral folic acid supplementation (0.5 mg/day) for the prevention of PHT-induced gingival overgrowth (PIGO) in children with epilepsy aged 6-15 years on PHT monotherapy for 6 months.
- Virulence and prodigiosin antibiotic biosynthesis in Serratia are regulated pleiotropically by the GGDEF/EAL domain protein, PigXPeter C Fineran
Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1QW, United Kingdom
J Bacteriol 189:7653-62. 2007..controlled secondary metabolism by repressing the transcription of the target prodigiosin biosynthetic operon (pigA-pigO)...
- Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesisT Kinoshita
Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, 565 0871, Osaka, Japan
Curr Opin Chem Biol 4:632-8. 2000..These studies have revealed the common and also different characteristics of glycosylphosphatidyl-inositol biosynthesis enzymes in different organisms, leading to the development of species-specific inhibitors of the pathway...
- Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositolY Hong
Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
J Biol Chem 275:20911-9. 2000..Therefore, mammalian cells have redundant activities in transferring phosphoethanolamine to the third mannose, both of which require PIG-F...