PICK1

Summary

Gene Symbol: PICK1
Description: protein interacting with PRKCA 1
Alias: PICK, PRKCABP, PRKCA-binding protein, protein interacting with C kinase 1, protein kinase C-alpha-binding protein
Species: human
Products:     PICK1

Top Publications

  1. Staudinger J, Zhou J, Burgess R, Elledge S, Olson E. PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol. 1995;128:263-71 pubmed
    ..One of these proteins, designated PICK1, interacts specifically with the catalytic domain of PKC and is an efficient substrate for phosphorylation by PKC ..
  2. Xia J, Zhang X, Staudinger J, Huganir R. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron. 1999;22:179-87 pubmed
    ..Here, we show that PICK1 (protein interacting with C kinase), a PDZ domain-containing protein, interacts with the C termini of alpha-amino-..
  3. Lu W, Ziff E. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Neuron. 2005;47:407-21 pubmed
    b>PICK1 and ABP/GRIP bind to the AMPA receptor (AMPAR) GluR2 subunit C terminus. Transfer of the receptor from ABP/GRIP to PICK1, facilitated by GluR2 S880 phosphorylation, may initiate receptor trafficking...
  4. Thorsen T, Madsen K, Rebola N, Rathje M, Anggono V, Bach A, et al. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proc Natl Acad Sci U S A. 2010;107:413-8 pubmed publisher
    ..Here we describe the first small-molecule inhibitor (FSC231) of the PDZ domain in protein interacting with C kinase 1 (PICK1) identified by a screening of approximately 44,000 compounds in a fluorescent polarization ..
  5. Bleecker M. Carbon monoxide intoxication. Handb Clin Neurol. 2015;131:191-203 pubmed publisher
    ..systems, indoor propane-powered forklifts, indoor burning of charcoal burning briquettes, riding in the back of pick-up trucks, ice skating rinks using propane-powered resurfacing machines, and gasoline-powered generators that are ..
  6. Lonsdale D. Thiamine and magnesium deficiencies: keys to disease. Med Hypotheses. 2015;84:129-34 pubmed publisher
    ..Results from acceptance of the hypothesis could be tested by performing erythrocyte transketolase tests to pick out those with TD and supplementing the affected individuals with the appropriate dietary supplements.
  7. Zheng Y, Jiang S, Zhang Y, Zhang R, Gong D. Detection of miR-33 Expression and the Verification of Its Target Genes in the Fatty Liver of Geese. Int J Mol Sci. 2015;16:12737-52 pubmed publisher
    ..triphosphate binding cassette transporters A1, adenosine triphosphate binding cassette transporters G1, Neimann Pick C, carnitine O-octanoyltransferase (CROT), cyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, beta ..
  8. Castillo J, Jelinek D, Wei H, Gannon N, Vaughan R, Horwood L, et al. The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways. Am J Physiol Endocrinol Metab. 2017;313:E183-E194 pubmed publisher
    A genome-wide association study (GWAS) reported that common variation in the human Niemann-Pick C1 gene (NPC1) is associated with morbid adult obesity...
  9. Li Z, Jiang H, Ding T, Lou C, Bui H, Kuo M, et al. Deficiency in lysophosphatidylcholine acyltransferase 3 reduces plasma levels of lipids by reducing lipid absorption in mice. Gastroenterology. 2015;149:1519-29 pubmed publisher
    ..showed that the control but not LPCAT3 KO mice accumulated lipids in the small intestine; levels of Niemann-Pick C1-like 1 (NPC1L1) and fatty acid transporter protein 4 (FATP4), which regulate lipid uptake, were greatly reduced ..

More Information

Publications146 found, 100 shown here

  1. Moore S, Hasler J. A 100-Year Review: Reproductive technologies in dairy science. J Dairy Sci. 2017;100:10314-10331 pubmed publisher
    ..leading to the birth of live calves, clones produced by nuclear transfer from embryonic cells, and ovum pick-up via ultrasound-guided follicular aspiration...
  2. Wang Y, Twu Y, Wang C, Lin F, Lee C, Liao Y. Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function. Int J Mol Sci. 2018;19: pubmed publisher
    ..Niemann-Pick type C2 (NPC2) plays an important role in the regulation of intracellular free cholesterol homeostasis via direct ..
  3. Kuo Y, Chen C, Chen Y, Yeh M, Lin P, Lee C, et al. The First Hand Allotransplantation in Taiwan: A Report at 9 Months. Ann Plast Surg. 2016;77 Suppl 1:S12-5 pubmed publisher
    ..The patient has a lateral pinch that allows him to pick up and grip objects during daily living, although his muscle power is still insufficient...
  4. Arias M. Keys to overcoming the challenge of diagnosing autosomal recessive spinocerebellar ataxia. Neurologia. 2016;: pubmed publisher
    ..abetalipoproteinaemia, ataxia with vitamin E deficiency, Refsum disease, cerebrotendinous xanthomatosis, Niemann-Pick disease type C, Wilson disease)...
  5. Dougherty M, Lazar J, Klein J, Diaz K, Gobillot T, Grunblatt E, et al. Genome sequencing in a case of Niemann-Pick type C. Cold Spring Harb Mol Case Stud. 2016;2:a001222 pubmed
    Adult-onset Niemann-Pick disease type C (NPC) is an infrequent presentation of a rare neurovisceral lysosomal lipid storage disorder caused by autosomal recessive mutations in NPC1 (?95%) or NPC2 (?5%)...
  6. Matsumoto A, Suzuki H, Fukatsu R, Shimizu H, Suzuki Y, Hisanaga K. An autopsy case of frontotemporal lobar degeneration with the appearance of fused in sarcoma inclusions (basophilic inclusion body disease) clinically presenting corticobasal syndrome. Neuropathology. 2016;36:77-87 pubmed publisher
    ..include corticobasal degeneration, Alzheimer's disease, PSP, FTLD with phosphorylated TDP-43 inclusions (FTLD-TDP), Pick's disease, Lewy body disease and CJD. However, FTLD-FUS (BIBD) has been rarely reported...
  7. Cianciola N, Chung S, Manor D, Carlin C. Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum. J Virol. 2017;91: pubmed publisher
    ..defects in the predominant cholesterol transport pathway regulated by the late endosomal membrane protein Niemann-Pick disease type C protein 1 (NPC1) arising during early stages of viral infection...
  8. Gagnon A, Khan D, Sirard M, Girard C, Laforest J, Richard F. Effects of intramuscular administration of folic acid and vitamin B12 on granulosa cells gene expression in postpartum dairy cows. J Dairy Sci. 2015;98:7797-809 pubmed publisher
    ..03) for treated and control cows, respectively. The ovarian follicle ≥12 mm in diameter was collected by ovum pick-up after estrus synchronization. Recovered follicular fluid volumes were greater in the vitamin-treated group...
  9. Koeppen A. The neuropathology of the adult cerebellum. Handb Clin Neurol. 2018;154:129-149 pubmed publisher
    ..Ataxia is a prominent feature of prion disease. Adult-onset Niemann-Pick type C1 disease and Kufs disease may have a predominantly ataxic clinical phenotype...
  10. Wirleitner B, Okhowat J, Vistejnova L, Kralickova M, Karlíková M, Vanderzwalmen P, et al. Relationship between follicular volume and oocyte competence, blastocyst development and live-birth rate: optimal follicle size for oocyte retrieval. Ultrasound Obstet Gynecol. 2018;51:118-125 pubmed publisher
    ..This was a prospective single-center study conducted between June 2012 and June 2014, including 118 ovum pick-ups with subsequent embryo transfer. Ovarian stimulation was performed using the GnRHa long protocol...
  11. Stenbæk D, Toftager M, Hjordt L, Jensen P, Holst K, Bryndorf T, et al. Mental distress and personality in women undergoing GnRH agonist versus GnRH antagonist protocols for assisted reproductive technology. Hum Reprod. 2015;30:103-10 pubmed publisher
    ..and the Major Depression Inventory questionnaires, at baseline, at ART cycle day 35, on the day of oocyte pick-up, and on the day of hCG testing...
  12. El Aamri F, Real F, Acosta F, Bravo J, Román L, Déniz S, et al. Differential innate immune response of European seabass (Dicentrarchus labrax) against Streptococcus iniae. Fish Shellfish Immunol. 2015;46:436-41 pubmed publisher
    ..However, interleukin-10 and Mx protein increased over time, reaching the pick of expression at 48 h post-infection, whereas caspase-3 showed down regulation until 48 h post-infection...
  13. Peter F, Rost S, Rolfs A, Frech M. Activation of PKC triggers rescue of NPC1 patient specific iPSC derived glial cells from gliosis. Orphanet J Rare Dis. 2017;12:145 pubmed publisher
    Niemann-Pick disease Type C1 (NPC1) is a rare progressive neurodegenerative disorder caused by mutations in the NPC1 gene. The pathological mechanisms, underlying NPC1 are not yet completely understood...
  14. Kennedy B, Hundert A, Goguen D, Weaver I, Karten B. Presymptomatic Alterations in Amino Acid Metabolism and DNA Methylation in the Cerebellum of a Murine Model of Niemann-Pick Type C Disease. Am J Pathol. 2016;186:1582-97 pubmed publisher
    The fatal neurodegenerative disorder Niemann-Pick type C (NPC) is caused in most cases by mutations in NPC1, which encodes the late endosomal NPC1 protein...
  15. Twu Y, Lee T, Lin Y, Hsu S, Wang Y, Liao C, et al. Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation. Int J Mol Sci. 2016;17: pubmed publisher
    ..Niemann-Pick type C2 (NPC2) protein plays an important role in the regulation of intracellular cholesterol homeostasis by ..
  16. Strupp M, Kremmyda O, Adamczyk C, Böttcher N, Muth C, Yip C, et al. Central ocular motor disorders, including gaze palsy and nystagmus. J Neurol. 2014;261 Suppl 2:S542-58 pubmed publisher
    ..or bleeding in the upper midbrain or in patients with chronic progressive supranuclear palsy (PSP) and Niemann-Pick type C (NP-C)...
  17. Stoeck I, Lee J, Tabata K, Romero Brey I, Paul D, Schult P, et al. Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis. J Virol. 2018;92: pubmed publisher
    ..domain protein 3 (STARD3), oxysterol-binding protein-related protein 1A and -B (OSBPL1A and -B), and Niemann-Pick-type C1 (NPC1), all residing at late endosome and lysosome membranes and required for efficient HCV RNA replication ..
  18. Geng Q, Ni L, Ouyang B, Hu Y, Zhao Y, Guo J. A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome Formation and Fertilization in Mice. Reprod Sci. 2016;23:1387-96 pubmed publisher
    ..The expression levels of proteins (SPACA1 and PICK1) involved in acrosome formation were significantly downregulated in the testes of Ccdc136(-/-) mice than wide-type ..
  19. Franciosi F, Tessaro I, Dalbies Tran R, Douet C, Reigner F, Deleuze S, et al. Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes. J Vis Exp. 2017;: pubmed publisher
    ..manuscript describes the procedures used for collecting immature and mature oocytes from horse ovaries using ovum pick-up (OPU)...
  20. Kanda T, Moriyama M. Direct-acting antiviral agents against hepatitis C virus and lipid metabolism. World J Gastroenterol. 2017;23:5645-5649 pubmed publisher
    ..Of note, low-density lipoprotein receptor, scavenger receptor class B type I and Niemann-Pick C1-like 1 proteins are candidate receptors that may be involved in HCV...
  21. Hayashi A, Webb J, Choi J, Baker C, Lino M, Trigatti B, et al. Intestinal SR-BI is upregulated in insulin-resistant states and is associated with overproduction of intestinal apoB48-containing lipoproteins. Am J Physiol Gastrointest Liver Physiol. 2011;301:G326-37 pubmed publisher
    ..transporters, adenosine triphosphate cassette (ABC) G5, ABCG8, FA-CoA ligase fatty acid translocase P4, Niemann-Pick C1-Like1 (NPC1L1), fatty acid transport protein 4 (FATP4), and Scavenger Receptor Class B Type I (SR-BI), were ..
  22. Munkacsi A, Hammond N, Schneider R, Senanayake D, Higaki K, Lagutin K, et al. Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat. J Biol Chem. 2017;292:4395-4410 pubmed publisher
    Niemann-Pick type C (NP-C) disease is a fatal genetic lipidosis for which there is no Food and Drug Administration (FDA)-approved therapy...
  23. Zhang C, Zhang R, Li Y, Liang N, Zhao Y, Zhu H, et al. Cholesterol-Lowering Activity of Tartary Buckwheat Protein. J Agric Food Chem. 2017;65:1900-1906 pubmed publisher
    ..Western blotting analyses showed that Tartary buckwheat protein affected the gene expression of intestinal Niemann-Pick C1-like protein 1 (NPC1L1), acyl CoA:cholesterol acyltransferase 2 (ACAT2), and ATP binding cassette transporters 5 ..
  24. Pillen S, Pizza F, Dhondt K, Scammell T, Overeem S. Cataplexy and Its Mimics: Clinical Recognition and Management. Curr Treat Options Neurol. 2017;19:23 pubmed publisher
    ..Next to narcolepsy, cataplexy can sometimes be caused by other diseases, such as Niemann-Pick type C, Prader Willi Syndrome, or lesions in the hypothalamic or pontomedullary region...
  25. Lund R, Leth Larsen R, Caterino T, Terp M, Nissen J, Lænkholm A, et al. NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer. Mol Cell Proteomics. 2015;14:2988-99 pubmed publisher
    ..cancer cell lines, including NADH-cytochrome b5 reductase 3 (CYB5R3), l-lactate dehydrogenase A (LDHA), Niemann-pick c1 protein (NPC1), and nucleolar RNA helicase 2 (NRH2)...
  26. Montjean D, Geoffroy Siraudin C, Gervoise Boyer M, Tourame P, Boyer P. Morphokinetics analysis of embryos derived from vitrified/warmed oocytes. J Assist Reprod Genet. 2015;32:1615-21 pubmed publisher
    ..This investigation included 90 infertility cases displaying large cohort of mature oocytes at pick up, divided into 2 groups after denudation. A part of oocytes underwent ICSI while others were vitrified...
  27. Schweitzer M, Makhoul S, Paliouras M, Beitel L, Gottlieb B, Trifiro M, et al. Characterization of the NPC1L1 gene and proteome from an exceptional responder to ezetimibe. Atherosclerosis. 2016;246:78-86 pubmed publisher
    ..Niemann-Pick C 1-like 1 (NPC1L1) is the molecular target of ezetimibe...
  28. Tsirogiannis P, Neophytou S, Reul A, Heydecke G, Reissmann D. Can we measure patients' perception during dental impressions? The Burdens in Dental Impression-Making Questionnaire - BiDIM-Q. J Prosthodont Res. 2017;61:34-42 pubmed publisher
    ..perceived burdens were low with highest burdens observed when using polyether in partially dentate patients for pick-up impressions, while lowest burdens were reported when using c-silicone for impressions of edentulous jaws...
  29. Farran E, Atkinson L. The development of spatial category representations from 4 to 7 years. Br J Dev Psychol. 2016;34:555-568 pubmed publisher
    ..nine spatial categories (In, On, Under, In Front, Behind, Above, Below, Left, and Right), children were asked to pick the odd-one-out from four images, three of which displayed the same spatial relationship between two objects, and ..
  30. Danielsen E, Moeller M, Yamanaka N, Ou Q, Laursen J, Soenderholm C, et al. A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing. Dev Cell. 2016;37:558-70 pubmed publisher
    ..of an autophagosomal cholesterol mobilization mechanism and show that activation of this system rescues Niemann-Pick type C1 deficiency that causes a disorder characterized by cholesterol accumulation...
  31. Gardner J. Standing on the shoulders of stem cell gene therapists: history, hyperbole and hope for the future. Hum Gene Ther Clin Dev. 2016;: pubmed publisher
    ..I thought it was timely to pick out a couple of observations from the development of Strimvelis to see how these might apply not only for the ..
  32. Cupidi C, Frangipane F, Gallo M, Clodomiro A, Colao R, Bernardi L, et al. Role of Niemann-Pick Type C Disease Mutations in Dementia. J Alzheimers Dis. 2017;55:1249-1259 pubmed
    ..Recently, mutations causative for Niemann-Pick type C disease (NPC) have also been implicated in neurodegenerative diseases...
  33. Mavridou I, Dimitriou E, Vanier M, Vilageliu L, Grinberg D, Latour P, et al. The Spectrum of Niemann-Pick Type C Disease in Greece. JIMD Rep. 2017;36:41-48 pubmed publisher
    Niemann-Pick type C disease (NPC) is a neurovisceral lysosomal storage disease caused by mutations in either the NPC1 or the NPC2 gene...
  34. Hernandez L, Adriaens D, Martin C, Wainwright P, Masschaele B, Dierick M. Building trophic specializations that result in substantial niche partitioning within a young adaptive radiation. J Anat. 2017;: pubmed publisher
    ..for cyprinodontiforms, in which the force of the bite may be secondary to the requisite dexterity needed to pick at food items, is modified within both the scale specialist and the durophagous species...
  35. Piraud M, Pettazzoni M, Lavoie P, Ruet S, Pagan C, Cheillan D, et al. Contribution of tandem mass spectrometry to the diagnosis of lysosomal storage disorders. J Inherit Metab Dis. 2018;41:457-477 pubmed publisher
    ..bile acids, and lysosphingolipids allows the screening of many sphingolipidoses and related disorders (Niemann-Pick type C), replacing tedious biochemical techniques...
  36. Zhong C, Sun W, Ma Y, Zhu H, Yang P, Wei H, et al. Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep. 2015;5:10512 pubmed publisher
    We have previously observed that knockout of Niemann-Pick C1-Like 1 (NPC1L1), a cholesterol transporter essential for intestinal cholesterol absorption, reduces the output of dry stool in mice...
  37. Goetzke F, Islam S. Determinants of seat belt use: A regression analysis with FARS data corrected for self-selection. J Safety Res. 2015;55:7-12 pubmed publisher
    ..on passengers (as opposed to drivers), male and young vehicle occupants, and that law enforcement should focus on pick-up trucks, rural roads, and nights. We find evidence that primary seat belt laws are effective...
  38. Yuan Q, Fu Z, Wei J, Li P, Miao H, Qu Y, et al. Identification and characterization of NPC1L1 variants in Uygur and Kazakh with extreme low-density lipoprotein cholesterol. Biochem Biophys Res Commun. 2016;479:628-635 pubmed publisher
    ..The Niemann-Pick C1 like 1 (NPC1L1) protein mediates efficient dietary cholesterol absorption and contributes to variations in human ..
  39. Gao S, Yu R, Zhou X. The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain. Mol Neurobiol. 2016;53:6925-6937 pubmed
    ..substrate GGPP in neurodegenerative disorders, such as aging, Alzheimer's disease, multiple sclerosis, and Niemann-Pick disease type C...
  40. Mohamed Thoufic Ali A, Agrawal A, Sajitha Lulu S, Mohana Priya A, Vino S. RAACFDb: Rheumatoid arthritis ayurvedic classical formulations database. J Ethnopharmacol. 2017;197:87-91 pubmed publisher
    ..The present newfangled care in clinical research is to determine and to pick a new track for better treatment options for RA...
  41. Widdowson W, McGowan A, Phelan J, Boran G, Reynolds J, Gibney J. Vascular Disease Is Associated With the Expression of Genes for Intestinal Cholesterol Transport and Metabolism. J Clin Endocrinol Metab. 2017;102:326-335 pubmed publisher
    ..One hundred patients undergoing routine oesophago-gastro-duodenoscopy were recruited. mRNA levels of Nieman-Pick C1-like 1 protein (NPC1L1), ABC-G5, ABC-G8, ABC-A1, microsomal tissue transport protein (MTTP), and sterol-..
  42. Brandão F, Alves B, Alves K, Souza S, Silva Y, Freitas V, et al. Laparoscopic ovarian biopsy pick-up method for goats. Theriogenology. 2018;107:219-225 pubmed publisher
    Biopsy pick-up (BPU) has been considered a safe method to harvest ovarian fragments from live animals. However, no studies have been reported on the use of BPU to collect in vivo ovarian tissue in goats...
  43. Mishra G, Bhatt S. Novel Program of Using Village Health Workers in Early Detection and Awareness of Head and Neck Cancers: Audit of a Community Screening Program. Indian J Otolaryngol Head Neck Surg. 2017;69:488-493 pubmed publisher
    ..Voluntary village health workers were educated and trained to pick up the early signs of head and neck cancers...
  44. Torres R, Firestein B, Dong H, Staudinger J, Olson E, Huganir R, et al. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 1998;21:1453-63 pubmed
    ..Thus, PDZ proteins may play critical roles in localizing vertebrate receptor tyrosine kinases and/or their ligands and may be particularly important for Eph function in guidance or patterning or at the synapse. ..
  45. Wang P, Zhang L, Xu X, Xiao G. Heuristic Strategies for Persuader Selection in Contagions on Complex Networks. PLoS ONE. 2017;12:e0169771 pubmed publisher
    ..is adopted to characterize each node's influence, based on which three heuristic strategies are applied to pick out persuaders. We compare these strategies for persuader selection on both homogeneous and heterogeneous networks...
  46. Moreno Ramirez D, Raya Maldonado J, Morales Conde M, Ojeda Vila T, Martín Gutiérrez F, Ruiz de Casas A, et al. Increasing Frequency of Seborrheic Keratosis Diagnoses as a Favorable Consequence of Teledermatology-Based Skin Cancer Screening: A Cross-sectional Study of 34,553 Patients. Am J Clin Dermatol. 2017;18:681-685 pubmed publisher
    ..Seborrheic keratoses, followed by benign melanocytic lesions, were the most frequent lesions diagnosed. The pick-up rate for malignant lesions was 1:8.6 teleconsultations...
  47. Glinka M, Weaver T, Laing A. Age-related differences in movement strategies and postural control during stooping and crouching tasks. Hum Mov Sci. 2015;44:246-57 pubmed publisher
    ..Compared to younger, older participants moved slower when transitioning into and out of pick-up postures that were characterized by less hip and knee flexion...
  48. Bosch M, Fajardo A, Alcalá Vida R, Fernández Vidal A, Tebar F, Enrich C, et al. Hepatic Primary and Secondary Cholesterol Deposition and Damage in Niemann-Pick Disease. Am J Pathol. 2016;186:517-23 pubmed publisher
    Niemann-Pick C disease is a neurovisceral disorder caused by mutations in the NPC gene that result in systemic accumulation of intracellular cholesterol...
  49. Dai S, Li G, Gao Y, Huang J. Pharmacophore-Map-Pick: A Method to Generate Pharmacophore Models for All Human GPCRs. Mol Inform. 2016;35:81-91 pubmed publisher
    ..With the aim to identify lead molecules for these GPCRs, we developed a new method called Pharmacophore-Map-Pick to generate pharmacophore models for all human GPCRs...
  50. Cermak S, Kosicek M, Mladenovic Djordjevic A, Smiljanic K, Kanazir S, Hecimovic S. Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins. PLoS ONE. 2016;11:e0167428 pubmed publisher
    ..upon CtsB/L inhibition resembled a phenotype characteristic for the rare neurodegenerative disorder Niemann-Pick type C (NPC)...
  51. Jae L, Brummelkamp T. Emerging intracellular receptors for hemorrhagic fever viruses. Trends Microbiol. 2015;23:392-400 pubmed publisher
    ..Recent screens for host factors identified such internal receptors for both viruses: Niemann-Pick disease type C1 protein (NPC1) for Ebola virus and lysosome-associated membrane protein 1 (LAMP1) for Lassa virus...
  52. Li L, Peng H, Chen X, Cheng J, Gao D. Visualization of boundaries in volumetric data sets through a what material you pick is what boundary you see approach. Comput Methods Programs Biomed. 2016;126:76-88 pubmed publisher
    ..Based on the model we present a boundary visualization method through a what material you pick is what boundary you see approach. Users can pick out the material of interest to directly convey semantics...
  53. Mercati O, Pichard S, Ouachée M, Froissart R, Fenneteau O, Roche B, et al. Limited benefits of presymptomatic cord blood transplantation in neurovisceral acid sphingomyelinase deficiency (ASMD) intermediate type. Eur J Paediatr Neurol. 2017;21:907-911 pubmed publisher
    Acid sphingomyelinase (ASM) deficient Niemann-Pick disease is a lysosomal storage disorder resulting from mutations in the SMPD1 gene...
  54. Garm A. Sensory Biology of Starfish-With Emphasis on Recent Discoveries in their Visual Ecology. Integr Comp Biol. 2017;57:1082-1092 pubmed publisher
    ..Accordingly, starfish are assumed to pick up rather limited information from the surroundings, and it is also often assumed that most of their behaviors are ..
  55. Seaman J, Alout H, Meyers J, Stenglein M, Dabiré R, Lozano Fuentes S, et al. Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals. BMC Genomics. 2015;16:797 pubmed publisher
    ..Transcripts from several unexpected functional classes were highly up-regulated, including Niemann-Pick Type C (NPC) genes, peritrophic matrix-associated genes, and immune-response genes, and these exhibited different ..
  56. Elustondo P, Martin L, Karten B. Mitochondrial cholesterol import. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:90-101 pubmed publisher
    ..been observed in diverse pathological conditions including cancer, steatohepatitis, Alzheimer disease and Niemann-Pick Type C1-deficiency, and are associated with increased oxidative stress, impaired oxidative phosphorylation, and ..
  57. Hung Y, Mangiafreno M, Gill S. Whole body organization during a symmetric bimanual pick up task in overweight and obese children. Gait Posture. 2017;52:95-99 pubmed publisher
    ..The purpose of the current study is to test the hypothesis that during a simple pick up task, overweight and obese children will organize their whole body movements differently than those in normal ..
  58. Iyer A, LaPointe N, Zielke K, Berdynski M, Guzman E, Barczak A, et al. A novel MAPT mutation, G55R, in a frontotemporal dementia patient leads to altered Tau function. PLoS ONE. 2013;8:e76409 pubmed publisher
    ..variety of neurodegenerative dementias known as tauopathies, including frontotemporal dementia (FTD), PSP, CBD and Pick's disease...
  59. Cerutti B, Blondon K, Galetto A. Long-menu questions in computer-based assessments: a retrospective observational study. BMC Med Educ. 2016;16:55 pubmed publisher
    ..Three types of formats are mainly used: Type A (single answer), Pick N, and Long-menu...
  60. Rounis E, Zhang Z, Pizzamiglio G, Duta M, Humphreys G. Factors influencing planning of a familiar grasp to an object: what it is to pick a cup. Exp Brain Res. 2017;235:1281-1296 pubmed publisher
    ..We interpret the results in terms of a parallel model of action selection, modulated by both the familiarity of the grasp to a part of the object, likely to reflect object 'affordances' and the end state comfort of the action. ..
  61. Ball K, Birch Y, Lane A, Ellison A, Schenk T. Comparing the effect of temporal delay on the availability of egocentric and allocentric information in visual search. Behav Brain Res. 2017;331:38-46 pubmed publisher
    Frames of reference play a central role in perceiving an object's location and reaching to pick that object up...
  62. Denhaerynck K, Berben L, Dobbels F, Russell C, Crespo Leiro M, Poncelet A, et al. Multi-level factors are associated with immunosuppressant nonadherence in heart transplant recipients: the international bright study. Am J Transplant. 2017;: pubmed publisher
    ..66); pick-up of medications at physician's office (OR: 2...
  63. Soufi M, Ruppert V, Kurt B, Schaefer J. The impact of severe LDL receptor mutations on SREBP-pathway regulation in homozygous familial hypercholesterolemia (FH). Gene. 2012;499:218-22 pubmed publisher
    Familial hypercholesterolemia (FH), Niemann-Pick disease type C (NPC) and Tangier disease (TD) are genetic inherited disorders with impaired processing of cholesterol, caused by mutations in genes that regulate cellular uptake, ..
  64. Falandysz J. Mercury bio-extraction by fungus Coprinus comatus: a possible bioindicator and mycoremediator of polluted soils?. Environ Sci Pollut Res Int. 2016;23:7444-51 pubmed publisher
    ..Young-fruiting bodies of C. comatus are edible and considered excellent if consumed soon after pick-up...
  65. Chen Y, Xu C, Huang R, Song J, Li D, Xia M. Butyrate from pectin fermentation inhibits intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E-deficient mice. J Nutr Biochem. 2018;56:175-182 pubmed publisher
    ..Incubation of Caco-2 cells with butyrate, but not acetate and propionate, down-regulated the expression of Niemann-Pick C1-Like 1 but up-regulated the ATP-binding cassette transporters G5 and G8 (ABCG5 and G8) at the mRNA level...
  66. Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, et al. Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease. Neurobiol Dis. 2016;94:32-43 pubmed publisher
    ..We observed that PICALM was associated with neuronal tau pathology in Pick disease and in progressive supranuclear palsy (PSP) and co-localised with both 3R and 4R tau positive inclusions ..
  67. Anoje C, Agu K, Oladele E, Badru T, Adedokun O, Oqua D, et al. Adherence to On-Time ART Drug Pick-Up and Its Association with CD4 Changes and Clinical Outcomes Amongst HIV Infected Adults on First-Line Antiretroviral Therapy in Nigerian Hospitals. AIDS Behav. 2017;21:386-392 pubmed publisher
    ..Promptness in medication refill pick-ups may give an indication of medication adherence...
  68. Iovinella I, Ban L, Song L, Pelosi P, Dani F. Proteomic analysis of castor bean tick Ixodes ricinus: a focus on chemosensory organs. Insect Biochem Mol Biol. 2016;78:58-68 pubmed publisher
    ..A third class of soluble proteins, called Niemann-Pick C2 (NPC2) has been suggested as potential carrier for semiochemicals both in insects and other arthropods...
  69. Dahlmans D, Houzelle A, Jorgensen J, Phielix E, Lindeboom L, Hesselink M, et al. Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups. Front Physiol. 2017;8:711 pubmed publisher
    ..Subsequently, the expression of selected miRNAs was determined by RT-qPCR using predesigned 384-well Pick-&-Mix miRNA PCR Panel plates in muscle biopsies from type 2 diabetes patients, non-diabetic obese/overweight ..
  70. Cenedella R. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids. 2009;44:477-87 pubmed publisher
    ..The inhibition of cholesterol trafficking by U18666A mimicked the loss of functional Niemann-Pick type C protein responsible for NPC disease and thus provided a model for this disorder...
  71. Yáñez M, Belbin O, Estrada L, Leal N, Contreras P, Lleo A, et al. c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease. Biochim Biophys Acta. 2016;1862:2158-2167 pubmed publisher
    Niemann-Pick type C (NPC) disease is characterized by lysosomal accumulation of cholesterol. Interestingly, NPC patients' brains also show increased levels of amyloid-? (A?) peptide, a key protein in Alzheimer's disease pathogenesis...
  72. Masingue M, Adanyeguh I, Nadjar Y, Sedel F, Galanaud D, Mochel F. Evolution of structural neuroimaging biomarkers in a series of adult patients with Niemann-Pick type C under treatment. Orphanet J Rare Dis. 2017;12:22 pubmed publisher
    Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by a wide clinical spectrum and non-specific conventional magnetic resonance imaging (MRI) signs...
  73. Ehlers J, Uchida A, Srivastava S. Intraoperative optical coherence tomography-compatible surgical instruments for real-time image-guided ophthalmic surgery. Br J Ophthalmol. 2017;101:1306-1308 pubmed publisher
    ..OCT-compatible instrumentation included two membrane scrapers, a surgical pick and vitreoretinal forceps...
  74. Jena P, Roxbury D, Galassi T, Akkari L, Horoszko C, Iaea D, et al. A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano. 2017;11:10689-10703 pubmed publisher
    ..phospholipidosis, was observed for multiple drugs in macrophages, and measurements of patient-derived Niemann-Pick type C fibroblasts identified lipid accumulation and phenotypic reversal of this lysosomal storage disease...
  75. Lally S, Owens D, Tomkin G. Genes that affect cholesterol synthesis, cholesterol absorption, and chylomicron assembly: the relationship between the liver and intestine in control and streptozotosin diabetic rats. Metabolism. 2007;56:430-8 pubmed
    ..The aim of this study was to compare the expression of Niemann-Pick C1-like1 (NPC1L1), adenosine triphosphate-binding cassette (ABC) proteins G5 and G8, microsomal triglyceride ..
  76. Tortorelli S, Turgeon C, Gavrilov D, Oglesbee D, Raymond K, Rinaldo P, et al. Simultaneous Testing for 6 Lysosomal Storage Disorders and X-Adrenoleukodystrophy in Dried Blood Spots by Tandem Mass Spectrometry. Clin Chem. 2016;62:1248-54 pubmed publisher
    ..approach is amenable to high-throughput population screening for Hurler disease, Gaucher disease, Niemann-Pick A/B disease, Pompe disease, Krabbe disease, Fabry disease, X-adrenoleukodystrophy, and peroxisomal biogenesis ..
  77. Bremova T, Krafczyk S, Bardins S, Reinke J, Strupp M. Vestibular function in patients with Niemann-Pick type C disease. J Neurol. 2016;263:2260-2270 pubmed
    ..whether vestibular dysfunction may cause or contribute to postural imbalance and falls in patients with Niemann-Pick type C disease (NP-C)...
  78. Xie C, Gong X, Luo J, Li B, Song B. AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease. J Lipid Res. 2017;58:512-518 pubmed publisher
    Niemann-Pick type C (NPC) disease is a fatal inherited neurodegenerative disorder caused by loss-of-function mutations in the NPC1 or NPC2 gene. There is no effective way to treat NPC disease...
  79. Vienken H, Mabrouki N, Grabau K, Claas R, Rudowski A, Schömel N, et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci Rep. 2017;7:43575 pubmed publisher
    ..lyase-deficient mice (Sgpl1-/--MEFs), in which S1P and sphingosine accumulate, have features of Niemann-Pick disease type C (NPC) cells...
  80. Lansdall C, Coyle Gilchrist I, Jones P, Vázquez Rodríguez P, Wilcox A, Wehmann E, et al. Apathy and impulsivity in frontotemporal lobar degeneration syndromes. Brain. 2017;140:1792-1807 pubmed publisher
    ..were determined by neuropsychological and behavioural assessments in 149 patients and 50 controls from the PIck's disease and Progressive supranuclear palsy Prevalence and INcidence study (PiPPIN)...
  81. Wang W, Ahn S. Shape Memory Alloy-Based Soft Gripper with Variable Stiffness for Compliant and Effective Grasping. Soft Robot. 2017;4:379-389 pubmed publisher
    ..The final demonstration shows that the finger with desired shape-retained configurations enables the gripper to successfully pick up a frustum-shaped object.
  82. Amigo L, Mendoza H, Castro J, Quinones V, Miquel J, Zanlungo S. Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice. Hepatology. 2002;36:819-28 pubmed
    ..Because Niemann-Pick C1 (NPC1) protein is a key component in the intracellular distribution of cholesterol obtained from lipoproteins by ..
  83. Kuzu O, Gowda R, Noory M, Robertson G. Modulating cancer cell survival by targeting intracellular cholesterol transport. Br J Cancer. 2017;117:513-524 pubmed publisher
    ..A potential approach involves disruption of intracellular cholesterol transport, which occurs in Niemann-Pick disease as a result of acid sphingomyelinase (ASM) deficiency...
  84. Hui D, Howles P. Molecular mechanisms of cholesterol absorption and transport in the intestine. Semin Cell Dev Biol. 2005;16:183-92 pubmed
    ..in determining the rate of cholesterol absorption; (ii) ATP binding cassette (ABC) transporters and the Niemann-Pick C-1 like-1 (NPC1L1) protein as intestinal membrane gatekeepers for cholesterol efflux and influx; and (iii) ..
  85. Boadu E, Choi H, Lee D, Waddington E, Chan T, Asztalos B, et al. Correction of apolipoprotein A-I-mediated lipid efflux and high density lipoprotein particle formation in human Niemann-Pick type C disease fibroblasts. J Biol Chem. 2006;281:37081-90 pubmed
    Impaired cell cholesterol trafficking in Niemann-Pick type C (NPC) disease results in the first known instance of impaired regulation of the ATP-binding cassette transporter A1 (ABCA1), a lipid transporter mediating the rate-limiting step ..
  86. Takada T, Suzuki H. Molecular mechanisms of membrane transport of vitamin E. Mol Nutr Food Res. 2010;54:616-22 pubmed publisher
    ..membrane proteins involved in these transport processes (ATP-binding cassette transporter A1, scavenger receptor class B type I, Niemann-Pick C1-like 1 and multidrug resistance 3) and vitamin E-mediated regulation of their expression.
  87. Ordoñez M, Steele J. Modeling Niemann Pick type C1 using human embryonic and induced pluripotent stem cells. Brain Res. 2017;1656:63-67 pubmed publisher
    Data generated in Niemann Pick type C1 (NPC1) human embryonic and human induced pluripotent stem cell derived neurons complement on-going studies in animal models and provide the first example, in disease-relevant human cells, of ..
  88. Simon T, Corey K, Chung R, Giugliano R. Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe. Dig Dis Sci. 2016;61:3425-3435 pubmed
    ..By potently inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) sterol receptor on intestinal enterocytes and within the liver, ezetimibe blocks exogenous ..
  89. Valasek M, Weng J, Shaul P, Anderson R, Repa J. Caveolin-1 is not required for murine intestinal cholesterol transport. J Biol Chem. 2005;280:28103-9 pubmed
    ..mice display normal mRNA and protein levels of Annexin-2 or the putative cholesterol transport protein Niemann-Pick C1-like 1 (NPC1L1) in proximal intestinal mucosa...
  90. Fujii K, Maeda K, Hikida T, Mustafa A, Balkissoon R, Xia J, et al. Serine racemase binds to PICK1: potential relevance to schizophrenia. Mol Psychiatry. 2006;11:150-7 pubmed
    ..In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the D-serine synthesizing enzyme, serine racemase (SR)...
  91. Wang M, Franklin V, Sundaram M, Kiss R, Ho K, Gallant M, et al. Differential regulation of ATP binding cassette protein A1 expression and ApoA-I lipidation by Niemann-Pick type C1 in murine hepatocytes and macrophages. J Biol Chem. 2007;282:22525-33 pubmed
    Niemann-Pick type C1 (Npc1) protein inactivation results in lipid accumulation in late endosomes and lysosomes, leading to a defect of ATP binding cassette protein A1 (Abca1)-mediated lipid efflux to apolipoprotein A-I (apoA-I) in ..
  92. Fiuza M, Rostosky C, Parkinson G, Bygrave A, Halemani N, Baptista M, et al. PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. J Cell Biol. 2017;216:3323-3338 pubmed publisher
    ..The mechanisms that link NMDAR activation to CME of AMPARs remain elusive. PICK1 is a BAR domain protein required for NMDAR-dependent reductions in surface GluA2; however, the molecular ..