PICALM

Summary

Gene Symbol: PICALM
Description: phosphatidylinositol binding clathrin assembly protein
Alias: CALM, CLTH, LAP, phosphatidylinositol-binding clathrin assembly protein, clathrin assembly lymphoid myeloid leukemia protein
Species: human
Products:     PICALM

Top Publications

  1. Huang F, Khvorova A, Marshall W, Sorkin A. Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem. 2004;279:16657-61 pubmed
    ..Surprisingly, knockdown of clathrin-assembly lymphoid myeloid leukemia protein, CALM, did not influence transferrin endocytosis but considerably affected EGFR internalization...
  2. Scotland P, Heath J, Conway A, Porter N, Armstrong M, Walker J, et al. The PICALM protein plays a key role in iron homeostasis and cell proliferation. PLoS ONE. 2012;7:e44252 pubmed publisher
    The ubiquitously expressed phosphatidylinositol binding clathrin assembly (PICALM) protein associates with the plasma membrane, binds clathrin, and plays a role in clathrin-mediated endocytosis...
  3. Schnetz Boutaud N, Hoffman J, Coe J, Murdock D, Pericak Vance M, Haines J. Identification and confirmation of an exonic splicing enhancer variation in exon 5 of the Alzheimer disease associated PICALM gene. Ann Hum Genet. 2012;76:448-53 pubmed publisher
    ..identified several new susceptibility genes including phosphatidylinositol-binding clathrin assembly protein (PICALM) on chromosome 11...
  4. Caudell D, Aplan P. The role of CALM-AF10 gene fusion in acute leukemia. Leukemia. 2008;22:678-85 pubmed
    ..recurring chromosomal translocation seen in patients with ALL as well as AML, and results in the production of a CALM-AF10 fusion gene...
  5. Caudell D, Zhang Z, Chung Y, Aplan P. Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice. Cancer Res. 2007;67:8022-31 pubmed
    To assess the role of the CALM-AF10 fusion gene in leukemic transformation in vivo, we generated transgenic mice that expressed a CALM-AF10 fusion gene...
  6. Carrasquillo M, Belbin O, Hunter T, Ma L, Bisceglio G, Zou F, et al. Replication of CLU, CR1, and PICALM associations with alzheimer disease. Arch Neurol. 2010;67:961-4 pubmed publisher
    To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease. Follow-up case-control association study. The Mayo Clinics at Jacksonville, Florida, and Rochester, Minnesota...
  7. Dreyling M, Martinez Climent J, Zheng M, Mao J, Rowley J, Bohlander S. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc Natl Acad Sci U S A. 1996;93:4804-9 pubmed
    ..gene approach, we cloned the breakpoint and were able to show that AF10 is fused to a novel gene that we named CALM (Clathrin Assembly Lymphoid Myeloid leukemia gene) located at 11q14...
  8. Wechsler D, Engstrom L, Alexander B, Motto D, Roulston D. A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. Genes Chromosomes Cancer. 2003;36:26-36 pubmed
    ..We used panhandle PCR to determine that this rearrangement juxtaposed the MLL (Mixed-Lineage Leukemia) gene to the CALM (Clathrin Assembly Lymphoid Myeloid leukemia) gene at 11q14-q21...
  9. Wu F, Matsuoka Y, Mattson M, Yao P. The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide. Biochem Biophys Res Commun. 2009;385:247-50 pubmed publisher
    ..Here we use a neuronal cell line to examine two structurally similar clathrin assembly proteins, AP180 and CALM. We show that RNA interference-mediated knockdown of AP180 reduces the generation of Abeta1-40 and Abeta1-42, ..

More Information

Publications87

  1. Ando K, Brion J, Stygelbout V, Suain V, Authelet M, Dedecker R, et al. Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol. 2013;125:861-78 pubmed publisher
    b>PICALM, a clathrin adaptor protein, plays important roles in clathrin-mediated endocytosis in all cell types...
  2. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere M, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet. 2009;41:1088-93 pubmed publisher
    ..4 x 10(-9)) and 5' to the PICALM gene (rs3851179, P = 1.9 x 10(-8))...
  3. Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, et al. Decreased CALM expression reduces A?42 to total A? ratio through clathrin-mediated endocytosis of ?-secretase. Nat Commun. 2014;5:3386 pubmed publisher
    ..Recently, a single-nucleotide polymorphism in phosphatidylinositol binding clathrin assembly protein (PICALM/CALM) gene, which encodes a protein implicated in the clathrin-mediated ..
  4. Chen L, Kao P, Fan Y, Ho D, Chan C, Yik P, et al. Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population. Neurobiol Aging. 2012;33:210.e1-7 pubmed publisher
    In this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from genome-wide association studies (GWAS) in a southern Chinese population...
  5. Sahlender D, Kozik P, Miller S, Peden A, Robinson M. Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation. PLoS ONE. 2013;8:e64514 pubmed publisher
    CALM (clathrin assembly lymphoid myeloid leukemia protein) is a cargo-selective adaptor for the post-Golgi R-SNAREs VAMPs 2, 3, and 8, and it also regulates the size of clathrin-coated pits and vesicles at the plasma membrane...
  6. Seshadri S, Fitzpatrick A, Ikram M, Destefano A, Gudnason V, Boada M, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010;303:1832-40 pubmed publisher
    Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  7. Harel A, Mattson M, Yao P. CALM, a clathrin assembly protein, influences cell surface GluR2 abundance. Neuromolecular Med. 2011;13:88-90 pubmed publisher
    The clathrin assembly protein, CALM, promotes the assembly of clathrin-coated vesicles...
  8. Maritzen T, Koo S, Haucke V. Turning CALM into excitement: AP180 and CALM in endocytosis and disease. Biol Cell. 2012;104:588-602 pubmed publisher
    ..N-terminal homology (ANTH) domain containing proteins AP180 and clathrin assembly lymphoid myeloid leukaemia (CALM) not only regulate the assembly of the endocytic machinery but also act as sorters for a subset of SNAREs, the ..
  9. Naj A, Jun G, Beecham G, Wang L, Vardarajan B, Buros J, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43:436-41 pubmed publisher
    ..3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1...
  10. Deshpande A, Cusan M, Rawat V, Reuter H, Krause A, Pott C, et al. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006;10:363-74 pubmed
    ..Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and immunoglobulin heavy chain rearrangement...
  11. D Angelo F, Vignaud H, Di Martino J, Salin B, Devin A, Cullin C, et al. A yeast model for amyloid-? aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity. Dis Model Mech. 2013;6:206-16 pubmed publisher
    ..Yeast PICALM orthologs are involved in cellular toxicity, indicating conservation of the mechanisms of toxicity from mammals to ..
  12. Meyerholz A, Hinrichsen L, Groos S, Esk P, Brandes G, Ungewickell E. Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. Traffic. 2005;6:1225-34 pubmed
    The endocytic accessory clathrin assembly lymphoid myeloid leukemia protein (CALM) is the ubiquitously expressed homolog of the neuron-specific protein AP180 that has been implicated in the retrieval of synaptic vesicle...
  13. Archangelo L, Glasner J, Krause A, Bohlander S. The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10. Oncogene. 2006;25:4099-109 pubmed
    The Clathrin Assembly Lymphoid Myeloid leukemia gene (CALM or PICALM) was first identified as the fusion partner of AF10 in the t(10;11)(p13;q14) translocation, which is observed in acute myeloid leukemia (AML), acute lymphoblastic ..
  14. Barral S, Bird T, Goate A, Farlow M, Diaz Arrastia R, Bennett D, et al. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology. 2012;78:1464-71 pubmed publisher
    ..Study, we conducted a family-based association study in which we tabulated MLGPs for SNPs at CR1, BIN1, CLU, PICALM, and APOE...
  15. Tebar F, Bohlander S, Sorkin A. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Mol Biol Cell. 1999;10:2687-702 pubmed
    The clathrin assembly lymphoid myeloid leukemia (CALM) gene encodes a putative homologue of the clathrin assembly synaptic protein AP180...
  16. Baig S, Joseph S, Tayler H, Abraham R, Owen M, Williams J, et al. Distribution and expression of picalm in Alzheimer disease. J Neuropathol Exp Neurol. 2010;69:1071-7 pubmed publisher
    b>PICALM, the gene encoding phosphatidylinositol-binding clathrin assembly (picalm) protein, was recently shown to be associated with risk of Alzheimer disease (AD). Picalm is a key component of clathrin-mediated endocytosis...
  17. Lambert J, Zelenika D, Hiltunen M, Chouraki V, Combarros O, Bullido M, et al. Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations. Neurobiol Aging. 2011;32:756.e11-5 pubmed publisher
    Recent genome-wide association studies have identified 5 loci (BIN1, CLU, CR1, EXOC3L2, and PICALM) as genetic determinants of Alzheimer's disease (AD)...
  18. Tian Y, Chang J, Fan E, Flajolet M, Greengard P. Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy. Proc Natl Acad Sci U S A. 2013;110:17071-6 pubmed publisher
    ..identified adaptor protein (AP) 2 together with phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) as binding proteins of microtubule-associated protein 1 light chain 3 (LC3)...
  19. Vecchi M, Polo S, Poupon V, Van de Loo J, Benmerah A, Di Fiore P. Nucleocytoplasmic shuttling of endocytic proteins. J Cell Biol. 2001;153:1511-7 pubmed
    ..Many endocytic proteins, including eps15, epsin1, the clathrin assembly lymphoid myeloid leukemia (CALM), and alpha-adaptin, accumulate in the nucleus when nuclear export is inhibited...
  20. Silliman C, McGavran L, Wei Q, Miller L, Li S, Hunger S. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides. Leukemia. 1998;12:1404-10 pubmed
    ..In U937, a cell line established from a diffuse histiocytic lymphoma, a t(10;11)(p13;q14-21) fuses AF10 to CALM. AF10 is also fused to MLL by a translocation that appears quite similar at the cytogenetic level, the t(10;11)(p12;..
  21. Li H, Shi S, Guo Q, Ni W, Dong Y, Liu Y, et al. PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients. J Alzheimers Dis. 2011;25:111-7 pubmed publisher
    ..studies (GWAS) identified 3 novel single nucleotide polymorphisms (SNPs) (rs11136000 within CLU, rs3851179 within PICALM and rs6656401 within CR1) that are associated with late-onset AD (LOAD), and these results have been replicated by ..
  22. Parikh I, Fardo D, Estus S. Genetics of PICALM expression and Alzheimer's disease. PLoS ONE. 2014;9:e91242 pubmed publisher
    ..Here, we evaluated the association between the AD-associated polymorphism rs3851179 near PICALM, which encodes a clathrin-coated pit accessory protein...
  23. Liu G, Zhang S, Cai Z, Ma G, Zhang L, Jiang Y, et al. PICALM gene rs3851179 polymorphism contributes to Alzheimer's disease in an Asian population. Neuromolecular Med. 2013;15:384-8 pubmed publisher
    b>PICALM gene rs3851179 polymorphism was reported to an Alzheimer's disease (AD) susceptibility locus in a Caucasian population. However, recent studies reported consistent and inconsistent results in an Asian population...
  24. Schjeide B, Schnack C, Lambert J, Lill C, Kirchheiner J, Tumani H, et al. The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Arch Gen Psychiatry. 2011;68:207-13 pubmed publisher
    ..studies independently implicated clusterin (CLU), complement receptor 1 (CR1), and phosphatidylinositol binding clathrin assembly protein (PICALM) as putative novel Alzheimer disease (AD) risk loci...
  25. Xiao Q, Gil S, Yan P, Wang Y, Han S, Gonzales E, et al. Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. J Biol Chem. 2012;287:21279-89 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) in the phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) gene were significantly associated with Alzheimer disease, suggesting a role in APP endocytosis and A? generation...
  26. Yu J, Song J, Ma T, Zhang W, Yu N, Xuan S, et al. Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese. J Neurol Sci. 2011;300:78-80 pubmed publisher
    b>PICALM might play an important role in AD pathology through participating in altering synaptic vesicle cycling or APP endocytosis...
  27. Harel A, Wu F, Mattson M, Morris C, Yao P. Evidence for CALM in directing VAMP2 trafficking. Traffic. 2008;9:417-29 pubmed publisher
    b>Clathrin assembly lymphoid myeloid leukemia protein (CALM) is a clathrin assembly protein with a domain structure similar to the neuron-specific assembly protein AP180...
  28. Jun G, Naj A, Beecham G, Wang L, Buros J, Gallins P, et al. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol. 2010;67:1473-84 pubmed publisher
    To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes...
  29. Miller K, Treloar T, Guelmann M, Rody W, Shaddox L. Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition. J Clin Pediatr Dent. 2018;42:95-102 pubmed publisher
    Due to the low prevalence of localized aggressive periodontitis (LAP), clinical characteristics of LAP in primary dentition are derived from a few case reports/series in the literature...
  30. Kawali A, Jose R, Aishwarya -, Kurian M, Kacha K, Mahendradas P, et al. Personality and uveitis. J Ophthalmic Inflamm Infect. 2016;6:36 pubmed
    ..Uveitis patients (n?=?56) showed positive personality trait: S (social), C (calm), O (organized), A (accommodative), and I (inquisitive)...
  31. Li W, Zhang J, Guo L, Chuai S, Shan L, Ying J. Combinational Analysis of FISH and Immunohistochemistry Reveals Rare Genomic Events in ALK Fusion Patterns in NSCLC that Responds to Crizotinib Treatment. J Thorac Oncol. 2017;12:94-101 pubmed publisher
    ..revealed two novel ALK partner genes, baculoviral IAP repeat containing 6 gene (BIRC6) and phosphatidylinositol binding clathrin assembly protein gene (PICALM)...
  32. Green C. New Nursing Faculty and Incivility: Applying Mindfulness-Based Strategies. Holist Nurs Pract. 2018;32:4-7 pubmed publisher
    ..can learn how to provide themselves self-care by reducing stress, as enhanced daily awareness of peace and calm are incorporated into their lifestyle...
  33. Choi W, Ranasinghe D, Bunavage K, DeShazo J, Wu L, Seguel R, et al. The effects of the built environment, traffic patterns, and micrometeorology on street level ultrafine particle concentrations at a block scale: Results from multiple urban sites. Sci Total Environ. 2016;553:474-485 pubmed publisher
    ..In the calm morning, the areal aspect ratio (Ararea), developed in this study for real urban configurations, showed a strong ..
  34. Scheffold K, Philipp R, Engelmann D, Schulz Kindermann F, Rosenberger C, Oechsle K, et al. Efficacy of a brief manualized intervention Managing Cancer and Living Meaningfully (CALM) adapted to German cancer care settings: study protocol for a randomized controlled trial. BMC Cancer. 2015;15:592 pubmed publisher
    ..manualized individual psychotherapy for patients with advanced cancer: Managing Cancer and Living Meaningfully (CALM)...
  35. Protopopova A, Hauser H, Goldman K, Wynne C. The effects of exercise and calm interactions on in-kennel behavior of shelter dogs. Behav Processes. 2018;146:54-60 pubmed publisher
    ..The study assessed the efficacy of two common enrichment strategies, providing calm interaction and additional exercise, on in-kennel behavior in 16 shelter dogs...
  36. Frost L, Dhingra A, Reyes Reveles J, Boesze Battaglia K. The Use of DQ-BSA to Monitor the Turnover of Autophagy-Associated Cargo. Methods Enzymol. 2017;587:43-54 pubmed publisher
    ..Such noncanonical pathways include LC3-associated phagocytosis, better known as LAP. Both autophagosomes and LAPosomes (LC3-associated phagosomes) deliver cargo for degradation...
  37. López Sánchez A, Leal Morales A, Jiménez Díaz L, Platero A, Bardallo Pérez J, Díaz Romero A, et al. Biofilm formation-defective mutants in Pseudomonas putida. FEMS Microbiol Lett. 2016;363: pubmed publisher
    ..Most of these mutants carried insertions in genes of the lap cluster, whose products are responsible for synthesis, export and degradation of the adhesin LapA...
  38. Caloro M, Calabrò G, Kotzalidis G, Cuomo I, Corkery J, Vento A, et al. Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths. Addict Behav. 2016;60:53-7 pubmed publisher
    ..She stated she was taking benzylglycinamide to calm her when smoking synthetic cannabinoids...
  39. Satoi S, Yanagimoto H, Yamamoto T, Toyokawa H, Hirooka S, Yamaki S, et al. A clinical role of staging laparoscopy in patients with radiographically defined locally advanced pancreatic ductal adenocarcinoma. World J Surg Oncol. 2016;14:14 pubmed publisher
    The aim of current study is to verify usefulness of staging laparoscopy (stag-lap) for patient's selection and to find prognostic factors in patients with radiographically defined locally advanced (RD-LA) pancreatic ductal adenocarcinoma ..
  40. Ferrari R, Ferrara M, Alinani A, Sutton R, Famà F, Picco A, et al. Screening of Early and Late Onset Alzheimer's Disease Genetic Risk Factors in a Cohort of Dementia Patients from Liguria, Italy. Curr Alzheimer Res. 2015;12:802-12 pubmed
    ..EOAD risk factors), as well as MAPT, GRN and TARDBP for all cases and NCs, and analysed the APOE, CLU, CR1 and PICALM genotypes as well as the MAPT and ACE haplotypes (LOAD risk factors) for the AD (n = 37) and AD + MCI (n = 45) ..
  41. Berry H, Peel D. Worrying about climate change: is it responsible to promote public debate?. BJPsych Int. 2015;12:31-32 pubmed
    ..Respectful, calm, considered public debate about how to respond to climate change is unlikely to be harmful to population mental ..
  42. Gutman B, Pizzagalli F, Jahanshad N, Wright M, McMahon K, de Zubicaray G, et al. APPROXIMATING PRINCIPAL GENETIC COMPONENTS OF SUBCORTICAL SHAPE. Proc IEEE Int Symp Biomed Imaging. 2017;2017:1226-1230 pubmed publisher
    ..Further, the genetic components are found to be significantly associated with the CLU and PICALM genes in an unrelated Alzheimer's Disease (AD) dataset...
  43. Parikh I, Medway C, Younkin S, Fardo D, Estus S. An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform. Mol Neurodegener. 2014;9:32 pubmed publisher
    Although genome wide studies have associated single nucleotide polymorphisms (SNP)s near PICALM with Alzheimer's disease (AD), the mechanism underlying this association is unclear...
  44. Medeiros S, Pinheiro Rosa N, Lemos L, Loli F, Pereira A, Santiago A, et al. Vitamin A supplementation leads to increases in regulatory CD4+Foxp3+LAP+ T cells in mice. Nutrition. 2015;31:1260-5 pubmed publisher
    ..Conversely, supplemented mice showed higher frequencies of CD4+Foxp3+LAP+ regulatory T cells in gut lymphoid tissues and spleen, suggesting that vitamin A supplementation in the diet may ..
  45. Chiang R, Chiang J, Hoogendoorn H, Lima M. Exploring the Role of Rhodtestolin, A Cardio-Inhibitor from the Testes of Rhodnius prolixus, in Relation to the Structure and Function of Reproductive Organs in Insect Vectors of Chagas Disease. Insects. 2013;4:593-608 pubmed publisher
    ..in reproduction remains unconfirmed, but if delivered to the female during spermatophore formation, it may serve to calm the female and/or relax the vaginal muscles to facilitate delivery and storage of the spermatophore...
  46. Rezende R, da Cunha A, Kuhn C, Rubino S, M Hamdi H, Gabriely G, et al. Identification and characterization of latency-associated peptide-expressing γδ T cells. Nat Commun. 2015;6:8726 pubmed publisher
    ..Here we describe a subset of regulatory γδ T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-β1...
  47. Wong L, Chowdhury N, Wang J, Chiu W, Kodikara J. Fatigue Damage Monitoring of a Composite Step Lap Joint Using Distributed Optical Fibre Sensors. Materials (Basel). 2016;9: pubmed publisher
    ..paper, a swept-wavelength interferometry (SWI) based DOFS technique is used to monitor the fatigue in a flush step lap joint composite structure...
  48. Allin N, Cruz Almeida Y, Velsko I, Vovk A, Hovemcamp N, Harrison P, et al. Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. J Dent Res. 2016;95:635-41 pubmed publisher
    ..response to bacterial lipopolysaccharide (LPS) in children with localized aggressive periodontitis (LAP). Additionally, different levels of this response were observed within the LAP group...
  49. Auner H, Iacobelli S, Sbianchi G, Knol Bout C, Blaise D, Russell N, et al. Melphalan 140 mg/m2 or 200 mg/m2 for autologous transplantation in myeloma: results from the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study. A report by the EBMT Chronic Malignancies Working Party. Haematologica. 2018;103:514-521 pubmed publisher
    ..In conclusion, remission status at the time of transplantation may favor the use of melphalan 200 mg/m2 or melphalan 140 mg/m2 for key transplant outcomes (NCT01362972). ..
  50. Minic Z, Wilson S, Liu F, Sankari A, Mao G, Goshgarian H. Nanoconjugate-bound adenosine A1 receptor antagonist enhances recovery of breathing following acute cervical spinal cord injury. Exp Neurol. 2017;292:56-62 pubmed publisher
    ..Frequency, tidal volume, and minute ventilation data were analyzed in two minute bins while the animal was calm and awake...
  51. Zhang S, Cai X, Luo X, Wang S, Guo A, Hou J, et al. Molecular cloning and characterization of leucine aminopeptidase gene from Taenia pisiformis. Exp Parasitol. 2018;186:1-9 pubmed publisher
    Leucine aminopeptidase (LAP, EC: 3.4.11.1) is an important metalloexopeptidase that catalyze the hydrolysis of amino-terminal leucine residues from polypeptides and proteins...
  52. Eleid M, Reeder G, Rihal C. Comparison of left atrial pressure monitoring with dedicated catheter versus steerable guiding catheter during transcatheter mitral valve repair. Catheter Cardiovasc Interv. 2017;: pubmed publisher
    The objective of this study was to determine the accuracy of left atrial pressure (LAP) measurement through the manufacturer provided steerable guiding catheter (SGC) during transcatheter mitral valve repair (TMVR).
  53. Lane R, Reis H, Hsu C, Kern K, Couderc J, Moss A, et al. Abnormal Repolarization Duration During Everyday Emotional Arousal in Long QT Syndrome and Coronary Artery Disease. Am J Med. 2018;131:565-572.e2 pubmed publisher
    ..affect and activated negative affect were associated with QTc shortening, whereas low arousal positive affect (calm and relaxed) was associated with QTc lengthening, which at times exceeded 500 msec...
  54. Ortega Rojas J, Morales L, Guerrero E, Arboleda Bustos C, Mejía A, Forero D, et al. Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients. Alzheimer Dis Assoc Disord. 2016;30:305-309 pubmed
    ..of several single-nucleotide polymorphisms in different genes including APOE, TOMM40, CR1, PVRL2, SORL1, PICALM, and GWA_14q32.13 in a Colombian sample of Late-Onset Alzheimer disease (LOAD) patients...
  55. Sale E, Hendricks M, Weil V, Miller C, Perkins S, McCudden S. Counseling on Access to Lethal Means (CALM): An Evaluation of a Suicide Prevention Means Restriction Training Program for Mental Health Providers. Community Ment Health J. 2018;54:293-301 pubmed publisher
    This paper evaluates the effectiveness of the Counseling on Access to Lethal Means (CALM) suicide prevention program...
  56. Martinez J, Cunha L, Park S, Yang M, Lu Q, Orchard R, et al. Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. Nature. 2016;533:115-9 pubmed publisher
    ..Previously, we and others described a form of noncanonical autophagy known as LC3-associated phagocytosis (LAP), in which phagosomes containing engulfed particles, including dying cells, recruit elements of the autophagy ..
  57. Ziemska J, Guśpiel A, Jarosz J, Nasulewicz Goldeman A, Wietrzyk J, Kawecki R, et al. Molecular docking studies, biological and toxicity evaluation of dihydroisoquinoline derivatives as potential anticancer agents. Bioorg Med Chem. 2016;24:5302-5314 pubmed publisher
    ..of a series of isoquinoline derivatives, including their synthesis, in vitro microsomal leucine aminopeptidase (LAP) inhibition and antiproliferative activity on cancer cell lines...
  58. Tian Q, Resnick S, Ferrucci L, Studenski S. Intra-individual lap time variation of the 400-m walk, an early mobility indicator of executive function decline in high-functioning older adults?. Age (Dordr). 2015;37:115 pubmed publisher
    Higher intra-individual lap time variation (LTV) of the 400-m walk is cross-sectionally associated with poorer attention in older adults...
  59. Mishra A, Srivastava R, Awasthi S, Parmar D, Mishra P. Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis. J Nucleic Acids. 2017;2017:3138254 pubmed publisher
    ..of the fingerprint of genes involved in the development of bones and cartilage such as GDF-5 or ESR-? or CALM-1 are known to be strong determinants of the osteoarthritis (OA) in Caucasian and Oriental populations...
  60. Campos F, Real Martinez C, Monteiro de Camargo M, Cesconetto D, Nahas S, Cecconello I. Laparoscopic Versus Open Restorative Proctocolectomy for Familial Adenomatous Polyposis. J Laparoendosc Adv Surg Tech A. 2017;: pubmed publisher
    This study compared outcomes after laparoscopic (LAP) or conventional (open) total proctocolectomy with outcomes after ileal J-pouch anal anastomosis (IPAA) at a single institution.
  61. Chen Y, Chen Y, Wang N, Chen C, Nie X, Li Q, et al. Thyroid Stimulating Hormone Within the Reference Range is Associated with Visceral Adiposity Index and Lipid Accumulation Product: A Population-Based Study of SPECT-China. Horm Metab Res. 2018;50:29-36 pubmed publisher
    ..of thyroid stimulating hormone (TSH) level with visceral adiposity index (VAI) and lipid accumulation product (LAP) in large Chinese population are available...
  62. Barrett M, Koeppel A, Flanigan J, Turner S, Worrall B. Investigation of Genetic Variants Associated with Alzheimer Disease in Parkinson Disease Cognition. J Parkinsons Dis. 2016;6:119-24 pubmed publisher
    ..In one dataset, PICALM rs3851179 was associated with cognitive impairment (MMSE <  24) in PD subjects > 70 years old (..
  63. Heckmann B, Boada Romero E, Cunha L, Magné J, Green D. LC3-Associated Phagocytosis and Inflammation. J Mol Biol. 2017;429:3561-3576 pubmed publisher
    LC3-associated phagocytosis (LAP) is a novel form of non-canonical autophagy where LC3 (microtubule-associated protein 1A/1B-light chain 3) is conjugated to phagosome membranes using a portion of the canonical autophagy machinery...
  64. Schlade Bartusiak K, Macintyre G, Zunich J, Cox D. A child with deletion (14)(q24.3q32.13) and auditory neuropathy. Am J Med Genet A. 2008;146A:117-23 pubmed
    ..Detailed mapping in additional patients with 14q32 deletions and hearing loss could further define the candidate region. ..
  65. Zhang W, Liu F, Zhang C, Luo J, Luo J, Yu W, et al. Near-Infrared Fluorescent Probe with Remarkable Large Stokes Shift and Favorable Water Solubility for Real-Time Tracking Leucine Aminopeptidase in Living Cells and In Vivo. Anal Chem. 2017;89:12319-12326 pubmed publisher
    Leucine aminopeptidase (LAP) is a kind of proteolytic enzymes and associated closely with pathogenesis of cancer and liver injury...
  66. Marsman R, Barc J, Beekman L, Alders M, Dooijes D, van den Wijngaard A, et al. A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence. J Am Coll Cardiol. 2014;63:259-66 pubmed publisher
    ..Our approach highlights the utility of exome sequencing in uncovering the genetic defect even in families with a small number of affected individuals. ..
  67. Darre T, Tchaou M, N Timon B, Patassi A, Aboubakari A, Sonhaye L, et al. Tuberculosis of the Breast in Togo: A Series of 28 Presumed Cases. Bull Soc Pathol Exot. 2017;110:238-241 pubmed publisher
    ..of breast tuberculosis for which the diagnosis was presumed on histological grounds in the pathology department (LAP) of the Lomé Tokoin university hospital from January 1995 to December 2016 (20 years)...
  68. Tashiro J, Wagenaar A, Perez E, Sola J. Peritoneal drainage is associated with higher survival rates for necrotizing enterocolitis in premature, extremely low birth weight infants. J Surg Res. 2017;218:132-138 pubmed publisher
    To evaluate peritoneal drainage (PD) and laparotomy ± resection/ostomy (LAP) as initial approaches to the surgical management of necrotizing enterocolitis (NEC) in premature, extremely low birth weight (ELBW) infants...
  69. Su Z, Qiu Q, Lin P. Design of Friction Stir Spot Welding Tools by Using a Novel Thermal-Mechanical Approach. Materials (Basel). 2016;9: pubmed publisher
    ..tools compared fracture behavior, microstructure, micro-hardness distribution, and welding temperature of welds in lap-shear specimens...
  70. Peng H, Chen D, Jiang X. Microstructure and Mechanical Properties of an Ultrasonic Spot Welded Aluminum Alloy: The Effect of Welding Energy. Materials (Basel). 2017;10: pubmed publisher
    The aim of this study is to evaluate the microstructures, tensile lap shear strength, and fatigue resistance of 6022-T43 aluminum alloy joints welded via a solid-state welding technique-ultrasonic spot welding (USW)-at different energy ..
  71. Oskouei R, Barati M, Ibrahim R. Surface Characterizations of Fretting Fatigue Damage in Aluminum Alloy 7075-T6 Clamped Joints: The Beneficial Role of Ni-P Coatings. Materials (Basel). 2016;9: pubmed publisher
    ..to characterize the surface damage as a consequence of fretting fatigue in aluminum alloy 7075-T6 plates in double-lap bolted joints through XRD, surface profilometry, and SEM analyses...
  72. Yang J, Cao B, Lu Q. The Effect of Welding Energy on the Microstructural and Mechanical Properties of Ultrasonic-Welded Copper Joints. Materials (Basel). 2017;10: pubmed publisher
    ..The lap shear load of the joints initially increased and then remained stable as the welding energy increased...
  73. Biffi A, Anderson C, Desikan R, Sabuncu M, Cortellini L, Schmansky N, et al. Genetic variation and neuroimaging measures in Alzheimer disease. Arch Neurol. 2010;67:677-85 pubmed publisher
    ..04) on all analyzed neuroimaging measures. The GWAS-validated variants at the CR1 and PICALM loci and markers at 2 novel loci (BIN1 and CNTN5) showed association with multiple magnetic resonance imaging ..
  74. Velsko I, Cruz Almeida Y, Huang H, Wallet S, Shaddox L. Cytokine response patterns to complex biofilms by mononuclear cells discriminate patient disease status and biofilm dysbiosis. J Oral Microbiol. 2017;9:1330645 pubmed publisher
    Localized aggressive periodontitis (LAP) is a rare form of periodontal disease with site-specific rapid tissue destruction...
  75. Wang D, He J, Guan X, Yang J, Zhang W. A model assessment method for predicting structural fatigue life using Lamb waves. Ultrasonics. 2018;84:319-328 pubmed publisher
    ..The model assessment and the influence of model choice on fatigue life prediction are made using both coupon testing data with artificial cracks and realistic lap joint testing data with naturally developed cracks.
  76. Kwon K, Sherman A, Chang W, Kamesh A, Biswas M, Herzog R, et al. Expression and assembly of largest foreign protein in chloroplasts: Oral delivery of human FVIII made in lettuce chloroplasts robustly suppresses inhibitor formation in hemophilia A mice. Plant Biotechnol J. 2017;: pubmed publisher
    ..7 BU/ml) in hemophilia A mice. Most importantly, increase in the frequency of circulating LAP-expressing CD4+ CD25+ FoxP3+ Treg in tolerized mice could be used as an important ..
  77. Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T. Partial loss of CALM function reduces A?42 production and amyloid deposition in vivo. Hum Mol Genet. 2016;25:3988-3997 pubmed publisher
    ..AD patients have identified the endocytosis-related phosphatidylinositol-binding clathrin assembly protein (PICALM) gene as a genetic risk factor for AD...
  78. Borba N, Afonso C, Blaga L, Dos Santos J, Canto L, Amancio Filho S. On the Process-Related Rivet Microstructural Evolution, Material Flow and Mechanical Properties of Ti-6Al-4V/GFRP Friction-Riveted Joints. Materials (Basel). 2017;10: pubmed publisher
    ..The mechanical performance was assessed on lap shear specimens, whereby the friction-riveted joints were connected with AA2198 gussets...