PI4KB

Summary

Gene Symbol: PI4KB
Description: phosphatidylinositol 4-kinase beta
Alias: NPIK, PI4K-BETA, PI4K92, PI4KBETA, PI4KIIIBETA, PIK4CB, phosphatidylinositol 4-kinase beta, PtdIns 4-kinase beta, phosphatidylinositol 4-kinase, catalytic, beta, phosphatidylinositol 4-kinase, wortmannin-sensitive, type III phosphatidylinositol 4-kinase beta
Species: human
Products:     PI4KB

Top Publications

  1. Greninger A, Knudsen G, Betegon M, Burlingame A, Derisi J. The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ. J Virol. 2012;86:3605-16 pubmed publisher
  2. Sasaki J, Ishikawa K, Arita M, Taniguchi K. ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites. EMBO J. 2012;31:754-66 pubmed publisher
    Phosphatidylinositol 4-kinase III? (PI4KB) is a host factor required for genome RNA replication of enteroviruses, small non-enveloped viruses belonging to the family Picornaviridae...
  3. Trotard M, Lepère Douard C, Régeard M, Piquet Pellorce C, Lavillette D, Cosset F, et al. Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening. FASEB J. 2009;23:3780-9 pubmed publisher
    ..Additional investigations on the different members of the PI4K family revealed that the presence of PI4KIIIbeta in the host cells influenced their susceptibility to HCVpp infection and their capacity to sustain the HCV ..
  4. Borawski J, Troke P, Puyang X, Gibaja V, Zhao S, Mickanin C, et al. Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication. J Virol. 2009;83:10058-74 pubmed publisher
    ..several enzymes required for HCV replication, including class III phosphatidylinositol 4-kinases (PI4KA and PI4KB), carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), and mevalonate (..
  5. Godi A, Pertile P, Meyers R, Marra P, Di Tullio G, Iurisci C, et al. ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. Nat Cell Biol. 1999;1:280-7 pubmed
    ..Phosphatidylinositol-4-OH kinase-beta is required for the structural integrity of the Golgi complex: transfection of a dominant-negative mutant of the kinase markedly alters the organization of the organelle. ..
  6. Weixel K, Blumental Perry A, Watkins S, Aridor M, Weisz O. Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases. J Biol Chem. 2005;280:10501-8 pubmed
    ..4-kinases (PI4Ks) have been localized to the Golgi complex in mammalian cells, type III PI4Kbeta (PI4KIIIbeta) and type II PI4Kalpha (PI4KIIalpha)...
  7. Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. J Biol Chem. 2002;277:20041-50 pubmed
    ..Our data indicate the existence of multiple forms of type II PI 4-kinase in mammalian cells and suggest that their functions are related to the endocytic pathway. ..
  8. Hausser A, Link G, Hoene M, Russo C, Selchow O, Pfizenmaier K. Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III beta protects from dephosphorylation and stabilizes lipid kinase activity. J Cell Sci. 2006;119:3613-21 pubmed
    Phosphatidylinositol-4-kinase-IIIbeta (PI4KIIIbeta) is activated at the Golgi compartment by PKD-mediated phosphorylation...
  9. Ibrahim M, Abdelrahman A, Hassan A. Identification of novel Plasmodium falciparum PI4KB inhibitors as potential anti-malarial drugs: Homology modeling, molecular docking and molecular dynamics simulations. Comput Biol Chem. 2019;80:79-89 pubmed publisher
    ..Performance of Autodock4.2 and Vina4 software in predicting the inhibitor-PI4KB binding mode and energy was assessed based on two Test Sets: Test Set I contained five ligands with resolved ..

More Information

Publications63

  1. Lyoo H, van der Schaar H, Dorobantu C, Rabouw H, Strating J, van Kuppeveld F. ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB. MBio. 2019;10: pubmed publisher
    ..Phosphatidylinositol 4-kinase IIIβ (PI4KB) is required by all enteroviruses for RO formation...
  2. Dorobantu C, Albulescu L, Lyoo H, van Kampen M, De Francesco R, Lohmann V, et al. Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein. mSphere. 2016;1: pubmed publisher
    ..poliovirus, coxsackievirus, and rhinovirus) subvert Golgi complex-localized phosphatidylinositol 4-kinase IIIβ (PI4KB) to generate "replication organelles" (ROs) enriched in phosphatidylinositol 4-phosphate (PI4P)...
  3. Chalupska D, Różycki B, Humpolickova J, Faltova L, Klíma M, Boura E. Phosphatidylinositol 4-kinase IIIβ (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins. Sci Rep. 2019;9:567 pubmed publisher
    Phosphatidylinositol 4-kinase IIIβ (PI4KB) is a key enzyme of the Golgi system because it produces its lipid hallmark - the phosphatidylinositol 4-phosphate (PI4P)...
  4. Kapp Barnea Y, Ninio Many L, Hirschberg K, Fukuda M, Jeromin A, Sagi Eisenberg R. Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment. Mol Biol Cell. 2006;17:4130-41 pubmed
    ..We further show that by activating phosphatidylinositol 4-kinase beta (PI4Kbeta) and increasing the cellular level of phosphatidylinositol(4) phosphate, neuronal calcium sensor-1 (NCS-1), a ..
  5. Campbell S, Franks C, Borne A, Shin M, Zhang L, Hsu K. Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells. Mol Pharmacol. 2018;94:1246-1255 pubmed publisher
    ..The unique target landscape combined with acceptable safety profiles in humans provides new opportunities for repositioning ritanserin in cancer. ..
  6. Xiao X, Lei X, Zhang Z, Ma Y, Qi J, Wu C, et al. Enterovirus 3A Facilitates Viral Replication by Promoting Phosphatidylinositol 4-Kinase IIIβ-ACBD3 Interaction. J Virol. 2017;91: pubmed publisher
    Like other enteroviruses, enterovirus 71 (EV71) relies on phosphatidylinositol 4-kinase IIIβ (PI4KB) for genome RNA replication. However, how PI4KB is recruited to the genome replication sites of EV71 remains elusive...
  7. Mana G, Clapero F, Panieri E, Panero V, Böttcher R, Tseng H, et al. PPFIA1 drives active ?5?1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nat Commun. 2016;7:13546 pubmed publisher
    ..We identify a pathway, comprising the regulators of post-Golgi carrier formation PI4KB and AP-1A, the small GTPase Rab11B, the surface tyrosine phosphatase receptor PTPRF and its adaptor PPFIA1, which ..
  8. Wortzel I, Hanoch T, Porat Z, Hausser A, Seger R. Mitotic Golgi translocation of ERK1c is mediated by a PI4KIIIβ-14-3-3γ shuttling complex. J Cell Sci. 2015;128:4083-95 pubmed publisher
    ..thereby allowing the binding of phosphorylated ERK1c to a complex that consists of PI4KIIIβ (also known as PI4KB) and the 14-3-3γ dimer (encoded by YWHAB)...
  9. Mansego M, Milagro F, Zulet M, Moreno Aliaga M, Martínez J. Differential DNA Methylation in Relation to Age and Health Risks of Obesity. Int J Mol Sci. 2015;16:16816-32 pubmed publisher
    ..In addition, DNA methylation of three CpG sites located in ELOVL2; HOXC4 and PI4KB were further negatively associated with their mRNA levels...
  10. Dorobantu C, Albulescu L, Harak C, Feng Q, van Kampen M, Strating J, et al. Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus. PLoS Pathog. 2015;11:e1005185 pubmed publisher
    ..g. poliovirus, coxsackievirus, rhinovirus) rely on the Golgi-localized phosphatidylinositol 4-kinase III beta (PI4KB), while cardioviruses replicate independently of the kinase...
  11. Silva G, He X, Parker J, Gatza M, Carey L, Hou J, et al. Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer. Breast Cancer Res Treat. 2015;152:347-56 pubmed publisher
    ..chromosome 1q21-23 as a Basal-like subtype-enriched region with multiple potential driver genes including PI4KB, SHC1, and NCSTN...
  12. Guedán A, Swieboda D, Charles M, Toussaint M, Johnston S, Asfor A, et al. Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication. J Virol. 2017;91: pubmed publisher
    ..have been identified, including oxysterol binding protein (OSBP) and phosphatidylinositol 4-kinase III beta (PI4KB)...
  13. Lupberger J, Casanova C, Fischer B, Weiss A, Fofana I, Fontaine N, et al. PI4K-beta and MKNK1 are regulators of hepatitis C virus IRES-dependent translation. Sci Rep. 2015;5:13344 pubmed publisher
    ..We demonstrate that the HCV host cell cofactors PI4K and MKNK1 are positive regulators of HCV IRES translation representing a novel pathway with a functional relevance for the HCV life cycle and IRES-mediated translation of viral RNA. ..
  14. Ishikawa Sasaki K, Nagashima S, Taniguchi K, Sasaki J. Model of OSBP-Mediated Cholesterol Supply to Aichi Virus RNA Replication Sites Involving Protein-Protein Interactions among Viral Proteins, ACBD3, OSBP, VAP-A/B, and SAC1. J Virol. 2018;92: pubmed publisher
    ..a picornavirus, forms a complex with the Golgi apparatus protein ACBD3 and phosphatidylinositol 4-kinase IIIβ (PI4KB) at viral RNA replication sites (replication organelles [ROs]), enhancing PI4KB-dependent phosphatidylinositol 4-..
  15. Hong Z, Yang X, Yang G, Zhang L. Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner. Antiviral Res. 2014;107:50-5 pubmed publisher
    Although genotype-dependency of PI4KB involved in HCV replication has been reported, the mechanism underlying that is unknown...
  16. Fowler M, McPhail J, Jenkins M, Masson G, Rutaganira F, Shokat K, et al. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Sci. 2016;25:826-39 pubmed publisher
    ..of hydrogen deuterium exchange mass spectrometry (HDX-MS) to identify dynamic regions within type III phosphatidylinositol 4 kinase beta (PI4KIIIβ) in complex with the GTPase Rab11...
  17. Melia C, van der Schaar H, Lyoo H, Limpens R, Feng Q, Wahedi M, et al. Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles. Cell Rep. 2017;21:587-599 pubmed publisher
    ..Although enterovirus replication depends on phosphatidylinositol 4-kinase type III? (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosphate (PI4P), is only partially understood...
  18. Dorobantu C, Ford Siltz L, Sittig S, Lanke K, Belov G, van Kuppeveld F, et al. GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins. J Virol. 2015;89:1913-8 pubmed publisher
    ..Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although HRV 3A was previously shown to interact with ACBD3, our data suggest that PI4KIIIβ recruitment occurred independently of both GBF1 and ACBD3. ..
  19. Eisenreichova A, Klíma M, Boura E. Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation. Acta Crystallogr F Struct Biol Commun. 2016;72:799-803 pubmed
    ..from the yeast Lachancea thermotolerans in the unliganded form and bound to a phosphopeptide derived from human PI4KB (phosphatidylinositol 4-kinase B)...
  20. Morrow A, Alipour M, Bridges D, Yao Z, Saltiel A, Lee J. The lipid kinase PI4KIII? is highly expressed in breast tumors and activates Akt in cooperation with Rab11a. Mol Cancer Res. 2014;12:1492-508 pubmed publisher
    ..Thus, PI4KIII? likely plays a role in breast oncogenesis and that cooperation between Rab11a and PI4KIII? represents a novel Akt activation pathway. ..
  21. Wong K, Meyers ddR -, Cantley L. Subcellular locations of phosphatidylinositol 4-kinase isoforms. J Biol Chem. 1997;272:13236-41 pubmed
    ..1996) Biochim. Biophys. Acta 1311, 53-63). Recently we isolated a distinct human PtdIns 4-kinase gene, named PI4Kbeta, that encodes an enzyme that is wortmannin sensitive (Meyers, R., and Cantley, L. C. (1997) J. Biol. Chem...
  22. Arita M. Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure. Microbiol Immunol. 2014;58:239-56 pubmed publisher
    ..have revealed an essential role of a novel cellular pathway via host phosphatidylinositol-4 kinase III beta (PI4KB) and oxysterol-binding protein (OSBP) family I in poliovirus (PV) replication...
  23. Zhao X, Varnai P, Tuymetova G, Balla A, Toth Z, Oker Blom C, et al. Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells. J Biol Chem. 2001;276:40183-9 pubmed
    ..that the Ca(2+)-binding protein, neuronal calcium sensor-1 (NCS-1), can physically associate with the type III PI4Kbeta with functional consequences affecting the kinase...
  24. Taverna E, Francolini M, Jeromin A, Hilfiker S, Roder J, Rosa P. Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis. J Cell Sci. 2002;115:3909-22 pubmed
    ..has been demonstrated to interact with and regulate the activity of yeast phosphatidylinositol 4-OH kinase beta (PI4Kbeta). However, in neurons and neurosecretory cells NCS-1 has not unequivocally been shown to interact with PI4Kbeta...
  25. Zhang L, Hong Z, Lin W, Shao R, Goto K, Hsu V, et al. ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. PLoS ONE. 2012;7:e32135 pubmed publisher
    ..Moreover, the vesicular transport proteins ARF1 and GBF1 colocalized with PI4KIII? and were both required for HCV replication. During authentic HCV infection, PI4P plays an integral role in virus replication. ..
  26. Jeganathan S, Lee J. Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation. J Biol Chem. 2007;282:372-80 pubmed
    ..Here, we report that eEF1A2 directly binds to and activates phosphatidylinositol 4-kinase III beta (PI4KIIIbeta), an enzyme that converts phosphatidylinositol to phosphatidylinositol 4-phosphate...
  27. Jung G, Barylko B, Lu D, Shu H, Yin H, Albanesi J. Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90. J Biol Chem. 2011;286:12775-84 pubmed publisher
  28. Pizarro Cerda J, Payrastre B, Wang Y, Veiga E, Yin H, Cossart P. Type II phosphatidylinositol 4-kinases promote Listeria monocytogenes entry into target cells. Cell Microbiol. 2007;9:2381-90 pubmed
    ..We demonstrate that PI4KIIalpha or PI4KIIbeta knockdown, but not type III PI4Kbeta knockdown, inhibits Listeria internalization...
  29. de Chassey B, Meyniel Schicklin L, Aublin Gex A, Navratil V, Chantier T, Andre P, et al. Structure homology and interaction redundancy for discovering virus-host protein interactions. EMBO Rep. 2013;14:938-44 pubmed publisher
    ..Validation was performed for the NS1 protein of the influenza virus, which led to the identification of new host factors that control viral replication. ..
  30. Chalupska D, Eisenreichova A, Różycki B, Rezabkova L, Humpolickova J, Klíma M, et al. Structural analysis of phosphatidylinositol 4-kinase IIIβ (PI4KB) - 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro. J Struct Biol. 2017;200:36-44 pubmed publisher
    Phosphatidylinositol 4-kinase IIIβ (PI4KB) is responsible for the synthesis of the Golgi and trans-Golgi network (TGN) pool of phosphatidylinositol 4-phospahte (PI4P)...
  31. McPhail J, Ottosen E, Jenkins M, Burke J. The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase III?, PI4KB, through ACBD3. Structure. 2017;25:121-131 pubmed publisher
    ..Rationally designed complex-disrupting mutations in both ACBD3 and PI4KIII? completely abrogated the sensitization of 3A activation by ACBD3. ..
  32. Toth B, Balla A, Ma H, Knight Z, Shokat K, Balla T. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem. 2006;281:36369-77 pubmed
    ..Therefore, PI 4-kinase beta is a key enzyme in the control of spingomyelin synthesis by controlling the flow of ceramide from the ER to the Golgi compartment. ..
  33. Klíma M, Tóth D, Hexnerová R, Baumlova A, Chalupska D, Tykvart J, et al. Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein. Sci Rep. 2016;6:23641 pubmed publisher
    Phosphatidylinositol 4-kinase beta (PI4KB) is one of four human PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but essential regulatory lipid found in all eukaryotic cells...
  34. Pinke D, Lee J. The lipid kinase PI4KIII? and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis. Exp Cell Res. 2011;317:2503-11 pubmed publisher
    ..Our work shows that PI4KIII?, eEF1A2 and PI(4)P likely play an important role in mammary neoplasia and acinar development. ..
  35. Greninger A, Knudsen G, Betegon M, Burlingame A, Derisi J. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. MBio. 2013;4:e00098-13 pubmed publisher
    ..binding domain protein 3 (ACBD3/GCP60) to recruit phosphatidylinositol 4-kinase class III beta (PI4KIIIβ/PI4KB), a factor required for viral replication...
  36. Ishikawa Sasaki K, Sasaki J, Taniguchi K. A complex comprising phosphatidylinositol 4-kinase III?, ACBD3, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is critical for formation of the viral replication complex. J Virol. 2014;88:6586-98 pubmed publisher
    Phosphatidylinositol 4-kinase III? (PI4KB) is a host factor required for the replication of certain picornavirus genomes...
  37. Chu K, Minogue S, Hsuan J, Waugh M. Differential effects of the phosphatidylinositol 4-kinases, PI4KII? and PI4KIII?, on Akt activation and apoptosis. Cell Death Dis. 2010;1:e106 pubmed publisher
  38. Meyers R, Cantley L. Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J Biol Chem. 1997;272:4384-90 pubmed
    ..Here we report the cloning of a novel, ubiquitously expressed PtdIns 4-kinase (PI4Kbeta). The 2...
  39. Saito T, Seki N, Ishii H, Ohira M, Hayashi A, Kozuma S, et al. Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene. DNA Res. 1997;4:301-5 pubmed
    ..The chromosomal location of the gene was determined by fluorescence in situ hybridization and PCR-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid mapping panel. ..
  40. Suer S, Sickmann A, Meyer H, Herberg F, Heilmeyer L. Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites. Eur J Biochem. 2001;268:2099-106 pubmed
    Human phosphatidylinositol 4-kinase, isoform PI4K92, was expressed as His6 tagged protein in Sf9 cells reaching a level of approximately 5% of cellular protein...
  41. Dubankova A, Humpolickova J, Klíma M, Boura E. Negative charge and membrane-tethered viral 3B cooperate to recruit viral RNA dependent RNA polymerase 3D pol. Sci Rep. 2017;7:17309 pubmed publisher
    ..viral 3A protein is sufficient to promote membrane hyper-phosphorylation given the proper intracellular cofactors (PI4KB and ACBD3)...
  42. Lyoo H, Dorobantu C, van der Schaar H, van Kuppeveld F. Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein. Antiviral Res. 2017;147:86-90 pubmed publisher
    ..Among these host factors are phosphatidylinositol-4-kinase IIIβ (PI4KB) and oxysterol binding protein (OSBP)...
  43. Sridhar S, Patel B, Aphkhazava D, Macian F, Santambrogio L, Shields D, et al. The lipid kinase PI4KIII? preserves lysosomal identity. EMBO J. 2013;32:324-39 pubmed publisher
  44. Burke J, Inglis A, Perisic O, Masson G, McLaughlin S, Rutaganira F, et al. Structures of PI4KIII? complexes show simultaneous recruitment of Rab11 and its effectors. Science. 2014;344:1035-8 pubmed publisher
  45. Kapp Barnea Y, Melnikov S, Shefler I, Jeromin A, Sagi Eisenberg R. Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells. J Immunol. 2003;171:5320-7 pubmed
    ..Both proteins associate in vivo with phosphatidylinositol 4-kinase beta (PI4Kbeta) and colocalize with the enzyme in the Golgi region...
  46. Yang N, Ma P, Lang J, Zhang Y, Deng J, Ju X, et al. Phosphatidylinositol 4-kinase III? is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry. J Biol Chem. 2012;287:8457-67 pubmed publisher
    ..Using gene knockdown technology, we demonstrate that phosphatidylinositol 4-kinase III? (PI4KB) is required for cellular entry by pseudoviruses bearing the severe acute respiratory syndrome-coronavirus (SARS-..
  47. Berryman S, Moffat K, Harak C, Lohmann V, Jackson T. Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases. J Gen Virol. 2016;97:1841-52 pubmed publisher
    ..These results point to a unique requirement towards lipids at the FMDV replication membranes. ..
  48. Arita M, Dobrikov G, Pürstinger G, Galabov A. Allosteric Regulation of Phosphatidylinositol 4-Kinase III Beta by an Antipicornavirus Compound MDL-860. ACS Infect Dis. 2017;3:585-594 pubmed publisher
    ..have characterized antipoliovirus activity of MDL-860 and identified host phosphatidylinositol-4 kinase III beta (PI4KB) as the target. MDL-860 treatment caused covalent modification and irreversible inactivation of PI4KB...
  49. Wei Y, Sun H, Yamamoto M, Wlodarski P, Kunii K, Martinez M, et al. Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP. J Biol Chem. 2002;277:46586-93 pubmed
    ..PI4KIIbeta is activated strongly by membrane association to stimulate phosphatidylinositol 4,5-bisphosphate synthesis at the plasma membrane. These findings provide new insight into how phosphoinositide cascades are propagated in cells. ..
  50. Heilmeyer L, Vereb G, Kakuk A, Szivak I. Mammalian phosphatidylinositol 4-kinases. IUBMB Life. 2003;55:59-65 pubmed
    ..PI4K230 has been found in the nucleolus, PI4K92 in the nucleus, additionally further broadening the function of these enzymes...
  51. Sorensen S, Linseman D, McEwen E, Heacock A, Fisher S. A role for a wortmannin-sensitive phosphatidylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors. Mol Pharmacol. 1998;53:827-36 pubmed
    ..Activity of PI4Kbeta present in immunoprecipitated cell lysates was inhibited >75% by inclusion of each of the three inhibitors...
  52. Zakharian E, Cao C, Rohacs T. Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P?. FASEB J. 2011;25:3915-28 pubmed publisher
    ..Our data establish PtdIns(4,5)P(2) as a direct activator of TRPV6 and demonstrate that intracellular ATP regulates the channel indirectly as a substrate for type III PI4Ks. ..
  53. Suzuki K, Hirano H, Okutomi K, Suzuki M, Kuga Y, Fujiwara T, et al. Identification and characterization of a novel human phosphatidylinositol 4-kinase. DNA Res. 1997;4:273-80 pubmed
    ..3- and 4-kinases allowed us to clone a novel human gene encoding a putative phosphatidylinositol kinase, NPIK. Among other known phosphatidylinositol 3- and 4-kinases, NPIK was most closely related to yeast PIK1 ..
  54. Jeganathan S, Morrow A, Amiri A, Lee J. Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation. Mol Cell Biol. 2008;28:4549-61 pubmed publisher
    ..We have previously reported that the eEF1A2 protein binds and activates phosphatidylinositol-4 kinase III beta (PI4KIIIbeta), and we find that production of eEF1A2-dependent PI(4,5)P(2) and generation of filopodia require PI4KIIIbeta...