phosphomevalonate kinase

Summary

Gene Symbol: phosphomevalonate kinase
Description: phosphomevalonate kinase
Alias: HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase, testis tissue sperm-binding protein Li 95mP
Species: human
Products:     phosphomevalonate kinase

Top Publications

  1. Shin H, Kaplan R, Duong T, Fakieh R, Reiner D. Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning. Cell Rep. 2018;24:2669-2681.e5 pubmed publisher
    ..Additionally, RAL-1 signals through GCK-2, a citron-N-terminal-homology-domain-containing MAP4 kinase, and PMK-1/p38 MAP kinase cascade to promote 2° fate...
  2. Pagano D, Kingston E, Kim D. Tissue expression pattern of PMK-2 p38 MAPK is established by the miR-58 family in C. elegans. PLoS Genet. 2015;11:e1004997 pubmed publisher
    ..miR-58 family of microRNAs sharply defines the tissue-specific expression of the broadly transcribed gene encoding PMK-2 p38 MAPK in Caenorhabditis elegans...
  3. Kim Y, Choudhry Q, Chatterjee N, Choi J. Immune and xenobiotic response crosstalk to chemical exposure by PA01 infection in the nematode Caenorhabditis elegans. Chemosphere. 2018;210:1082-1090 pubmed publisher
    ..Further, a functional genetic analysis revealed that the immune response pathway (i.e., PMK-1/p38 MAPK) was involved in defense against AgNP exposure in PA01-preinfected C...
  4. Kamaladevi A, Balamurugan K. Role of PMK-1/p38 MAPK defense in Caenorhabditis elegans against Klebsiella pneumoniae infection during host-pathogen interaction. Pathog Dis. 2015;73: pubmed publisher
    ..In addition, the genetic analysis in N2 wild type, tol-1, sek-1 and pmk-1 mutants unveiled that KP attenuates the toll-dependent p38 mitogen-activated protein kinase (p38 MAPK) by chiefly ..
  5. Di R, Zhang H, Lawton M. Transcriptome Analysis of C. elegans Reveals Novel Targets for DON Cytotoxicity. Toxins (Basel). 2018;10: pubmed publisher
    ..8 and K08D8.5 encoding PMK-1 (mitogen activated protein kinase-1)-regulated immune effectors, and F35E12...
  6. Cai Y, Cao X, Aballay A. Whole-animal chemical screen identifies colistin as a new immunomodulator that targets conserved pathways. MBio. 2014;5: pubmed publisher
    ..We identified 45 marketed drugs, out of 1,120 studied compounds, that are capable of activating a conserved p38/PMK-1 mitogen-activated protein kinase pathway required for innate immunity...
  7. Si Y, Wen H, Li Y, He F, Li J, Li S, et al. Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis. BMC Genomics. 2018;19:464 pubmed publisher
    ..The candidate genes identified from this study provide a basis for further studies to investigate the molecular mechanism of salinity adaptation and transcriptional plasticity in marine fish. ..
  8. Chen B, Cao X, Lu H, Wen P, Qi X, Chen S, et al. N-(3-oxo-acyl) homoserine lactone induced germ cell apoptosis and suppressed the over-activated RAS/MAPK tumorigenesis via mitochondrial-dependent ROS in C. elegans. Apoptosis. 2018;23:626-640 pubmed publisher
    ..damage response (hus-1, clk-2 and cep-1) and genes involved in p38 and JNK/MAPK signaling pathway (nsy-1, sek-1, pmk-1, mkk-4 and jnk-1)...
  9. Wang J, Du H, Nie Y, Wang Y, Dai H, Wang M, et al. Mitochondria and MAPK cascades modulate endosulfan-induced germline apoptosis in Caenorhabditis elegans. Toxicol Res (Camb). 2017;6:412-419 pubmed publisher
    ..apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-induced germ cell ..

More Information

Publications66

  1. Henry L, Thomas S, Widhalm J, Lynch J, Davis T, Kessler S, et al. Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nat Plants. 2018;4:721-729 pubmed publisher
    ..the unpredicted peroxisomal localization of bacterial MPD led us to discover that the step catalysed by phosphomevalonate kinase (PMK) imposes a hidden constraint on flux through the classical MVA pathway...
  2. Bond M, Ghosh S, Wang P, Hanover J. Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity. PLoS ONE. 2014;9:e113231 pubmed publisher
    ..nutrient-responsive OGT-1 acts through the conserved β-catenin (BAR-1) pathway and in concert with p38 MAPK (PMK-1) to modulate the immune response to S. aureus...
  3. Choi Y, Kim N, Lee J, Nam R, Chang H, Seo J, et al. Protective effects of garlic extract, PMK-S005, against nonsteroidal anti-inflammatory drugs-induced acute gastric damage in rats. Dig Dis Sci. 2014;59:2927-34 pubmed publisher
    b>PMK-S005 is synthetic s-allyl-L-cysteine (SAC), a sulfur-containing amino acid, which was initially isolated from garlic...
  4. Malhotra N, Kumar V, Sood H, Singh T, Chauhan R. Multiple genes of mevalonate and non-mevalonate pathways contribute to high aconites content in an endangered medicinal herb, Aconitum heterophyllum Wall. Phytochemistry. 2014;108:26-34 pubmed publisher
    ..2 folds) showed 11-100 folds increase in transcript amounts of 4 genes of MVA pathway; HMGS, HMGR, PMK, IPPI, and 4 genes of MEP pathway; DXPS, ISPD, HDS, GDPS, respectively...
  5. Sonnessa S, Sebastianelli A, De Lucia G, Rauzino J, Lala N, Mingoia C, et al. [The cardiological evaluation in patients undergoing to Day Surgery: when is indicated]. Clin Ter. 2014;165:e404-12 pubmed publisher
    ..34 with congestive heart failure; 6 with the alterations in EKG : 3 with "Brugada pattern"; 1 with Pace Maker (PMK) that had to be reprogrammed before the operation; 3 under dual antiplatelet therapy; 7 that were taking the oral ..
  6. Kostons D, van der Werf G. The effects of activating prior topic and metacognitive knowledge on text comprehension scores. Br J Educ Psychol. 2015;85:264-75 pubmed publisher
    ..the effects of both prior topic knowledge activation (PTKA) and prior metacognitive knowledge activation (PMKA) on text comprehension scores...
  7. Park M, Ryu S, Maburutse B, Oh N, Kim S, Oh S, et al. Probiotic Lactobacillus fermentum strain JDFM216 stimulates the longevity and immune response of Caenorhabditis elegans through a nuclear hormone receptor. Sci Rep. 2018;8:7441 pubmed publisher
    ..revealed that the health-promoting effects of JDFM216 were mediated by a nuclear hormone receptor (NHR) family and PMK-1 signaling. Taken together, we described a new C...
  8. Lio A, Murzi M, Di Stefano G, Miceli A, Kallushi E, Ferrarini M, et al. Triple valve surgery in the modern era: short- and long-term results from a single centre. Interact Cardiovasc Thorac Surg. 2014;19:978-84 pubmed publisher
    ..5, 95% CI 1.5-5.7, P = 0.006), prolonged CPB time (HR 1.02, 95% CI 1.01-1.13, P = 0.006), postoperative pacemaker (PMK) implantation (HR 6.2, 95% CI 1.3-18, P = 0.01) and postoperative pulmonary complications (HR 3.3, 95% CI 2.1-7...
  9. Xu X, Xue Y, Zhang F, Qin X, Peng B, Tian H, et al. [Analysis of digital gene expression profiles of the cultivated Polygala tenuifolia in different phenological phases]. Yao Xue Xue Bao. 2016;51:1165-74 pubmed
    ..tenuifolia from flowering fruit bearing stage to dormancy stage. Six differentially expressed genes (HMGS, PMK, FPPS, SQS, SE, ?-AS) and five (PAL, C4 H, 4CL, CAD, peroxidase) were annotated to the triterpenoid saponins and ..
  10. Wang Y, Chen B, Su K, Sun L, Zhang Y, Guo L, et al. [Hyperkalemia-induced failure of pacemaker capture and sensing: a case report]. Beijing Da Xue Xue Bao Yi Xue Ban. 2014;46:980-2 pubmed
    ..It may cause cardiac pacemaker (PMK) malfunctioning due to a reduction of the electronegativity of the resting myocardial potential...
  11. Shakoor S, Sun L, Wang D. Multi-walled carbon nanotubes enhanced fungal colonization and suppressed innate immune response to fungal infection in nematodes. Toxicol Res (Camb). 2016;5:492-499 pubmed publisher
    ..With regard to the underlying molecular mechanisms, we found that MWCNTs decreased expression levels of pmk-1, sek-1, and nsy-1 genes encoding the p38 mitogen activated protein kinase (MAPK) signaling ..
  12. Tietze A, Hansen M, Østergaard L, Jespersen S, Sangill R, Lund T, et al. Mean Diffusional Kurtosis in Patients with Glioma: Initial Results with a Fast Imaging Method in a Clinical Setting. AJNR Am J Neuroradiol. 2015;36:1472-8 pubmed publisher
    ..842; pmk' < .001)...
  13. Cooke M, Wilk P, Paul K, Gonneville S. Predictors of obesity among Métis children: socio-economic, behavioural and cultural factors. Can J Public Health. 2013;104:e298-303 pubmed
    ..Métis children, including child height and weight, reported by the person most knowledgeable about the child (PMK). Multivariate binary logistic regression was used to predict obesity, defined using IOTF BMI cut-offs...
  14. Hsu C, Chan D, Greggio E, Saha S, Guillily M, Ferree A, et al. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem. 2010;112:1593-604 pubmed publisher
    ..elegans. RNAi knockdown in C. elegans of the endogenous orthologs for MKK6 or p38, sek-1 and pmk-1, abolishes LRRK2-mediated protection against mitochondrial stress...
  15. Kamaladevi A, Balamurugan K. Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection. Food Funct. 2016;7:3211-23 pubmed publisher
    ..casei treated loss-of-function mutants of the tol-1, RACK-1 and p38 MAPK pathway (sek-1 and pmk-1) to K. pneumoniae infection and gene expression analysis suggested that L...
  16. Park E, Rongo C. The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons. elife. 2016;5: pubmed publisher
    ..elegans. Mutants lacking p38 MAPK components pmk-1 or sek-1 resemble mutants lacking the hypoxia response component and prolyl hydroxylase egl-9, with impaired ..
  17. Cheng T, Liu H, Zou H, Chen N, Shi M, Xie C, et al. Enzymatic process optimization for the in vitro production of isoprene from mevalonate. Microb Cell Fact. 2017;16:8 pubmed publisher
    ..The optimized process using 10 balanced enzyme unites (5.0 µM of MVK, PMK, MVD; 10.0 µM of IDI, 80.0 µM of ISPS) could produce 6323...
  18. Cheesman H, Feinbaum R, Thekkiniath J, Dowen R, Conery A, Pukkila Worley R. Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans. G3 (Bethesda). 2016;6:541-9 pubmed publisher
    ..hypomorphic mutations in each of the known components of the p38 MAP kinase cassette (tir-1, nsy-1, sek-1, and pmk-1), demonstrating that hyperstimulation of the p38 MAPK pathway is toxic to animals...
  19. George K, Thompson M, Kim J, Baidoo E, Wang G, Benites V, et al. Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli. Metab Eng. 2018;47:60-72 pubmed publisher
    ..We show that IPP toxicity selects for pathway "breakage", using proteomics to identify a reduction in phosphomevalonate kinase (PMK) as a probable recovery mechanism. Next, using multi-omics data, we demonstrate that endogenous E...
  20. Hall J, McElwee M, Freedman J. Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. PLoS ONE. 2017;12:e0177432 pubmed publisher
    ..b>PMK-1 and members of the insulin signaling pathway, PDK-1 and AKT-1/2, were also identified as mtl-1 regulators...
  21. Shitiz K, Sharma N, Pal T, Sood H, Chauhan R. NGS Transcriptomes and Enzyme Inhibitors Unravel Complexity of Picrosides Biosynthesis in Picrorhiza kurroa Royle ex. Benth. PLoS ONE. 2015;10:e0144546 pubmed publisher
    ..showed elevated transcripts for twenty genes, which were further shortlisted to seven key genes, ISPD, DXPS, ISPE, PMK, 2HFD, EPSPS and SK, on the basis of expression analysis between high versus low picrosides content strains of P...
  22. Wang J, Kaletsky R, Silva M, Williams A, Haas L, Androwski R, et al. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Curr Biol. 2015;25:3232-8 pubmed publisher
    ..factor (TRAF) homologs trf-1 and trf-2 and the p38 mitogen-activated protein kinase (MAPK) pmk-1 acted in polycystin-signaling pathways controlling male mating behaviors...
  23. Padhan J, Kumar V, Sood H, Singh T, Chauhan R. Contents of therapeutic metabolites in Swertia chirayita correlate with the expression profiles of multiple genes in corresponding biosynthesis pathways. Phytochemistry. 2015;116:38-47 pubmed publisher
    ..gene expression analysis and their subsequent principal component analysis unveiled ten genes (encoding HMGR, PMK, MVK, ISPD, ISPE, GES, G10H, 8HGO, IS and 7DLGT) of the secoiridoids biosynthesis pathway and five genes (encoding ..
  24. Cao X, Aballay A. Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner. Curr Biol. 2016;26:2329-34 pubmed publisher
    ..Chlorpromazine inhibition of DOP-4 in the nervous system activates a microbicidal PMK-1/p38 mitogen-activated protein kinase signaling pathway that enhances host resistance against bacterial infections...
  25. Williams E, Baines K, Berthon B, Wood L. Effects of an Encapsulated Fruit and Vegetable Juice Concentrate on Obesity-Induced Systemic Inflammation: A Randomised Controlled Trial. Nutrients. 2017;9: pubmed publisher
    ..and 5' adenosine monophosphate-activated protein kinase (AMPK) signalling pathways was altered, including phosphomevalonate kinase (PMVK), zinc finger AN1-type containing 5 (ZFAND5) and calcium binding protein 39 (CAB39), respectively...
  26. Li W, Wang D, Wang D. Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling. Sci Rep. 2018;8:857 pubmed publisher
    ..Simulated microgravity treatment significantly increased the transcriptional expressions of genes (pmk-1, sek-1, and nsy-1) encoding core p38 MAPK signaling pathway and the expression of phosphorylated PMK-1/p38 MAPK...
  27. Li Q, Ding G, Li B, Guo S. Transcriptome Analysis of Genes Involved in Dendrobine Biosynthesis in Dendrobium nobile Lindl. Infected with Mycorrhizal Fungus MF23 (Mycena sp.). Sci Rep. 2017;7:316 pubmed publisher
    ..16 unigenes, selected randomly, proved that there were significant changes in the expression levels of AACT, MVD, PMK and TPS21 at 9 weeks after inoculation...
  28. D Amora D, Hu Q, Pizzardi M, Kubiseski T. BRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1. Cell Death Differ. 2018;25:1276-1288 pubmed publisher
    ..following DNA damage in brap-2 mutants and that skn-1 RNAi knockdown in brap-2;brc-1 double mutants and a loss of pmk-1 mutation in brap-2 mutants increased apoptosis to wild type levels, indicating that brap-2 promotion of cell ..
  29. Sharma V, Salwan R, Sharma P, Kanwar S. Elucidation of biocontrol mechanisms of Trichoderma harzianum against different plant fungal pathogens: Universal yet host specific response. Int J Biol Macromol. 2017;95:72-79 pubmed publisher
    ..the transcripts were upregulated at various time intervals but the optimum expression of cyp3, abc, nrp, tga1, pmk, ech42 and glh20 varied with respect to host fungi...
  30. Munkácsy E, Khan M, Lane R, Borror M, Park J, Bokov A, et al. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet. 2016;12:e1006133 pubmed publisher
    ..This novel cascade is defined by DLK-1 (MAP3K), SEK-3 (MAP2K), PMK-3 (MAPK) and the reporter gene Ptbb-6::GFP...
  31. E L, Zhou T, Koh S, Chuang M, Sharma R, Pujol N, et al. An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. Neuron. 2018;97:125-138.e5 pubmed publisher
    ..elegans. The age-dependent increase of nlp-29 expression is regulated by the epidermal tir-1/SARM-pmk-1/p38 MAPK innate immunity pathway...
  32. Kim K, Thakur N, Piggott C, Omi S, Polanowska J, Jin Y, et al. Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development. BMC Biol. 2016;14:104 pubmed
    ..elegans Tribbles NIPI-3 was previously shown to activate host defense upon infection by promoting the conserved PMK-1/p38 mitogen-activated protein kinase (MAPK) signalling pathway...
  33. Buhaescu I, Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications. Clin Biochem. 2007;40:575-84 pubmed
    ..Here we present a brief description of the biochemistry of the mevalonate pathway, together with a review of the current knowledge of the clinical and therapeutical implications of this fascinating and complex metabolic pathway. ..
  34. Olson A, Yao H, Herdendorf T, Miziorko H, Hannongbua S, Saparpakorn P, et al. Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. Proteins. 2009;75:127-38 pubmed publisher
    b>Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans...
  35. Andreassi J, Leyh T. Molecular functions of conserved aspects of the GHMP kinase family. Biochemistry. 2004;43:14594-601 pubmed
    ..and three-dimensional structures of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family were compared to identify highly conserved surface residues...
  36. Bai R, Latifi Z, Kusama K, Nakamura K, Shimada M, Imakawa K. Induction of immune-related gene expression by seminal exosomes in the porcine endometrium. Biochem Biophys Res Commun. 2018;495:1094-1101 pubmed publisher
    ..These observations indicated that exosomes present in SP are involved in the immune-related gene regulation in the uterus, which could pave the passage for sperm and possibly fertilized eggs. ..
  37. Boonsri P, Neumann T, Olson A, Cai S, Herdendorf T, Miziorko H, et al. Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase. Biochem Biophys Res Commun. 2013;430:313-9 pubmed publisher
    b>Phosphomevalonate kinase (PMK) phosphorylates mevalonate-5-phosphate (M5P) in the mevalonate pathway, which is the sole source of isoprenoids and steroids in humans...
  38. Shu C, Sun L, Zhang W. Thymol has antifungal activity against Candida albicans during infection and maintains the innate immune response required for function of the p38 MAPK signaling pathway in Caenorhabditis elegans. Immunol Res. 2016;64:1013-24 pubmed publisher
    ..Moreover, among the genes that encode the p38 MAPK signaling pathway, mutation of the pmk-1 or sek-1 gene decreased the beneficial effects of thymol's antifungal activity against C...
  39. Keshet A, Mertenskötter A, Winter S, Brinkmann V, Dölling R, Paul R. PMK-1 p38 MAPK promotes cadmium stress resistance, the expression of SKN-1/Nrf and DAF-16 target genes, and protein biosynthesis in Caenorhabditis elegans. Mol Genet Genomics. 2017;292:1341-1361 pubmed publisher
    ..Survival assays on mutant and control animals revealed a significant promotion of Cd resistance by the PMK-1 p38 MAP kinase, the transcription factor DAF-16/FoxO, and the ABC transporter MRP-1...
  40. Miziorko H. Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch Biochem Biophys. 2011;505:131-43 pubmed publisher
    ..a common protein fold, animal enzymes differ in this respect as the recently reported structure of human phosphomevalonate kinase demonstrates...
  41. Yan F, Chen X, Zheng X. Protective effect of mulberry fruit anthocyanin on human hepatocyte cells (LO2) and Caenorhabditis elegans under hyperglycemic conditions. Food Res Int. 2017;102:213-224 pubmed publisher
    ..reduction as well as total superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity recovery and PMK-1/p38 expression promotion...
  42. Hu Q, D Amora D, MacNeil L, Walhout A, Kubiseski T. The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2. Genetics. 2017;206:1909-1922 pubmed publisher
    ..mutants display increased expression of SKN-1-dependent, phase II detoxification enzymes that is dependent on PMK-1 (a p38 MAPK C. elegans ortholog)...
  43. Herdendorf T, Miziorko H. Phosphomevalonate kinase: functional investigation of the recombinant human enzyme. Biochemistry. 2006;45:3235-42 pubmed
    b>Phosphomevalonate kinase (PMK) catalyzes a key step in isoprenoid/sterol biosynthesis, converting mevalonate 5-phosphate and ATP to mevalonate 5-diphosphate and ADP...
  44. Hogenboom S, Wanders R, Waterham H. Cholesterol biosynthesis is not defective in peroxisome biogenesis defective fibroblasts. Mol Genet Metab. 2003;80:290-5 pubmed
    ..been reported to be partly or exclusively peroxisomal and include HMG-CoA reductase, mevalonate kinase, phosphomevalonate kinase, mevalonate pyrophosphate decarboxylase, and isopentenyl pyrophosphate isomerase...
  45. Li X, Zhou Q, Zhu L, Zhao Z, Wang P, Zhang L, et al. [Analysis of clinical and genetic features of nine patients with disseminated superfacial actinic porokeratosis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:481-485 pubmed publisher
    ..c.746 T>C and c.875A>G of the MVD gene are most common mutations. Skin rashes of the patients have a strong connection with the sunlight, albeit a significant difference among patients was discovered. ..
  46. Olivier L, Chambliss K, Gibson K, Krisans S. Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. J Lipid Res. 1999;40:672-9 pubmed
    b>Phosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme...
  47. Zhang Z, Li C, Wu F, Ma R, Luan J, Yang F, et al. Genomic variations of the mevalonate pathway in porokeratosis. elife. 2015;4:e06322 pubmed publisher
  48. Hogenboom S, Tuyp J, Espeel M, Koster J, Wanders R, Waterham H. Phosphomevalonate kinase is a cytosolic protein in humans. J Lipid Res. 2004;45:697-705 pubmed
    ..In this study, we have determined the subcellular localization of human phosphomevalonate kinase using a variety of biochemical and microscopic techniques, including conventional subcellular ..
  49. Chang Q, Yan X, Gu S, Liu J, Liang D. Crystal structure of human phosphomevalonate kinase at 1.8 A resolution. Proteins. 2008;73:254-8 pubmed publisher
  50. Herdendorf T, Miziorko H. Functional evaluation of conserved basic residues in human phosphomevalonate kinase. Biochemistry. 2007;46:11780-8 pubmed
    b>Phosphomevalonate kinase (PMK) catalyzes the cation-dependent reaction of mevalonate 5-phosphate with ATP to form mevalonate 5-diphosphate and ADP, a key step in the mevalonate pathway for isoprenoid/sterol biosynthesis...
  51. Kwon G, Lee J, Koh J, Lim Y. Lifespan Extension of Caenorhabditis elegans by Butyricicoccus pullicaecorum and Megasphaera elsdenii with Probiotic Potential. Curr Microbiol. 2018;75:557-564 pubmed publisher
    ..coli OP50-fed worms. However, the increase in lifespan was observed in daf-16, jnk-1, pmk-1, and skn-1 mutants. Moreover, they increased the resistance of C...
  52. Krisans S, Ericsson J, Edwards P, Keller G. Farnesyl-diphosphate synthase is localized in peroxisomes. J Biol Chem. 1994;269:14165-9 pubmed
    ..the activities of five enzymes involved in isoprenoid synthesis, namely mevalonate kinase, phosphomevalonate kinase, mevalonate-diphosphate decarboxylase, isopentenyl-diphosphate isomerase, and FPP synthase, are ..
  53. Chambliss K, Slaughter C, Schreiner R, Hoffmann G, Gibson K. Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence. J Biol Chem. 1996;271:17330-4 pubmed
    Two overlapping cDNAs which encode human liver phosphomevalonate kinase (PMKase) were isolated...
  54. Kovacs W, Tape K, Shackelford J, Duan X, Kasumov T, Kelleher J, et al. Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Histochem Cell Biol. 2007;127:273-90 pubmed
    ..concluding that three of the peroxisomal cholesterol biosynthetic enzymes, namely mevalonate kinase, phosphomevalonate kinase, and mevalonate diphosphate decarboxylase, do not localize to peroxisomes in human cells even though they ..
  55. Ellinor P, Lunetta K, Albert C, Glazer N, Ritchie M, Smith A, et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet. 2012;44:670-5 pubmed publisher
    ..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules. ..
  56. Wang J, Liu Y, Liu F, Huang C, Han S, Lv Y, et al. Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis. Sci Rep. 2016;6:24226 pubmed publisher
    ..412C > T (p.Arg138*) in the phosphomevalonate kinase gene (PMVK), which encodes a cytoplasmic enzyme catalyzing the conversion of mevalonate 5-phosphate to ..
  57. Head B, Olaitan A, Aballay A. Role of GATA transcription factor ELT-2 and p38 MAPK PMK-1 in recovery from acute P. aeruginosa infection in C. elegans. Virulence. 2017;8:261-274 pubmed publisher
    ..We determined that the GATA transcription factor ELT-2 and the p38 MAP kinase PMK-1 are necessary for animals to successfully recover from an acute P. aeruginosa infection...