Gene Symbol: phospholamban
Description: phospholamban
Alias: CMD1P, CMH18, PLB, cardiac phospholamban
Species: human
Products:     phospholamban

Top Publications

  1. Asahi M, Kurzydlowski K, Tada M, MacLennan D. Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs). J Biol Chem. 2002;277:26725-8 pubmed
    ..of fast-twitch skeletal muscle (SERCA1a), is also expressed in cardiac and slow-twitch skeletal muscles where phospholamban (PLN) and SERCA2a are expressed...
  2. Asahi M, Sugita Y, Kurzydlowski K, de Leon S, Tada M, Toyoshima C, et al. Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban. Proc Natl Acad Sci U S A. 2003;100:5040-5 pubmed
    b>Phospholamban (PLN), a regulator of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs), interacts with both the cytosolic N domain and transmembrane helices M2, M4, M6, and M9 of SERCA...
  3. Landstrom A, Adekola B, Bos J, Ommen S, Ackerman M. PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing. Am Heart J. 2011;161:165-71 pubmed publisher
    ..We sought to determine the spectrum and prevalence of mutations in PLN-encoded phospholamban in a large cohort of HCM cases as a potential cause of mutation-negative HCM...
  4. Schmitt J, Kamisago M, Asahi M, Li G, Ahmad F, Mende U, et al. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science. 2003;299:1410-3 pubmed
    ..congestive heart failure is caused by a dominant Arg --> Cys missense mutation at residue 9 (R9C) in phospholamban (PLN), a transmembrane phosphoprotein that inhibits the cardiac sarcoplasmic reticular Ca2+-adenosine ..
  5. Oxenoid K, Chou J. The structure of phospholamban pentamer reveals a channel-like architecture in membranes. Proc Natl Acad Sci U S A. 2005;102:10870-5 pubmed
    ..Human phospholamban (PLN), expressed in the sarcoplasmic reticulum membrane as a 30-kDa homopentamer, controls cellular calcium ..
  6. Haghighi K, Kolokathis F, Gramolini A, Waggoner J, Pater L, Lynch R, et al. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proc Natl Acad Sci U S A. 2006;103:1388-93 pubmed
    ..we identified a previously uncharacterized deletion of arginine 14 (PLN-R14Del) in the coding region of the phospholamban (PLN) gene in a large family with hereditary heart failure. No homozygous individuals were identified...
  7. Abu Baker S, Lu J, Chu S, Shetty K, Gor Kov P, Lorigan G. The structural topology of wild-type phospholamban in oriented lipid bilayers using 15N solid-state NMR spectroscopy. Protein Sci. 2007;16:2345-9 pubmed
    For the first time, 15N solid-state NMR experiments were conducted on wild-type phospholamban (WT-PLB) embedded inside mechanically oriented phospholipid bilayers to investigate the topology of its cytoplasmic and transmembrane domains...
  8. Haghighi K, Chen G, Sato Y, Fan G, He S, Kolokathis F, et al. A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids. Hum Mutat. 2008;29:640-7 pubmed publisher
    Depressed calcium handling by the sarcoplasmic reticulum (SR) Ca-ATPase and its regulator phospholamban (PLN) is a key characteristic of human and experimental heart failure...
  9. Schmitt J, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, et al. Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition. Circulation. 2009;119:436-44 pubmed publisher
    Low activity of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) resulting from strong inhibition by phospholamban (PLN) can depress cardiac contractility and lead to dilated cardiomyopathy and heart failure...

More Information

Publications104 found, 100 shown here

  1. Verardi R, Shi L, Traaseth N, Walsh N, Veglia G. Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method. Proc Natl Acad Sci U S A. 2011;108:9101-6 pubmed publisher
    b>Phospholamban (PLN) is a type II membrane protein that inhibits the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle...
  2. Haghighi K, Pritchard T, Bossuyt J, Waggoner J, Yuan Q, Fan G, et al. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. J Mol Cell Cardiol. 2012;52:773-82 pubmed publisher
    ..b>Phospholamban (PLN) is a key regulator of SR and cardiac function, and PLN mutations in humans have been associated with ..
  3. Ceholski D, Trieber C, Young H. Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy. J Biol Chem. 2012;287:16521-9 pubmed publisher
    The sarco(endo)plasmic reticulum calcium ATPase (SERCA) and its regulatory partner phospholamban (PLN) are essential for myocardial contractility...
  4. van der Zwaag P, van Rijsingen I, Asimaki A, Jongbloed J, van Veldhuisen D, Wiesfeld A, et al. Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy. Eur J Heart Fail. 2012;14:1199-207 pubmed publisher
    To investigate whether phospholamban gene (PLN) mutations underlie patients diagnosed with either arrhythmogenic right ventricular cardiomyopathy (ARVC) or idiopathic dilated cardiomyopathy (DCM)...
  5. Minamisawa S, Sato Y, Tatsuguchi Y, Fujino T, Imamura S, Uetsuka Y, et al. Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy. Biochem Biophys Res Commun. 2003;304:1-4 pubmed
    b>Phospholamban is an endogenous inhibitor of sarcoplasmic reticulum calcium ATPase and plays a prime role in cardiac contractility and relaxation. Phospholamban may be a candidate gene responsible for cardiomyopathy...
  6. Pfeufer A, Sanna S, Arking D, Müller M, Gateva V, Fuchsberger C, et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet. 2009;41:407-14 pubmed publisher
    ..These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD. ..
  7. Trieber C, Afara M, Young H. Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump. Biochemistry. 2009;48:9287-96 pubmed publisher
    Regulation of the SERCA calcium pump by phospholamban (PLB) is largely due to interactions between their respective transmembrane domains...
  8. Ha K, Masterson L, Hou Z, Verardi R, Walsh N, Veglia G, et al. Lethal Arg9Cys phospholamban mutation hinders Ca2+-ATPase regulation and phosphorylation by protein kinase A. Proc Natl Acad Sci U S A. 2011;108:2735-40 pubmed publisher
    The regulatory interaction of phospholamban (PLN) with Ca(2+)-ATPase controls the uptake of calcium into the sarcoplasmic reticulum, modulating heart muscle contractility...
  9. Smeazzetto S, Schröder I, Thiel G, Moncelli M. Phospholamban generates cation selective ion channels. Phys Chem Chem Phys. 2011;13:12935-9 pubmed publisher
    ..The PLN generated channel activity could be inhibited by a PLN antibody (abPLN) implying that the channel activity is indeed due to the inherent channel function of the PLN protein. ..
  10. Medeiros A, Biagi D, Sobreira T, de Oliveira P, Negrao C, Mansur A, et al. Mutations in the human phospholamban gene in patients with heart failure. Am Heart J. 2011;162:1088-1095.e1 pubmed publisher
    b>Phospholamban (PLN) is a crucial Ca(2+) cycling protein and a primary mediator of the ?-adrenergic effects resulting in enhanced cardiac output...
  11. Haghighi K, Kolokathis F, Pater L, Lynch R, Asahi M, Gramolini A, et al. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest. 2003;111:869-76 pubmed
    ..In mice, disruption of the PLN gene encoding phospholamban (PLN) or expression of dominant-negative PLN mutants enhances SR and cardiac function, but effects of PLN ..
  12. Medin M, Hermida Prieto M, Monserrat L, Laredo R, Rodriguez Rey J, Fernandez X, et al. Mutational screening of phospholamban gene in hypertrophic and idiopathic dilated cardiomyopathy and functional study of the PLN -42 C>G mutation. Eur J Heart Fail. 2007;9:37-43 pubmed
    b>Phospholamban is an endogenous sarcoplasmic reticulum calcium ATPase inhibitor with a regulatory effect on cardiac contraction/relaxation coupling...
  13. DeWitt M, MacLeod H, Soliven B, McNally E. Phospholamban R14 deletion results in late-onset, mild, hereditary dilated cardiomyopathy. J Am Coll Cardiol. 2006;48:1396-8 pubmed
    The purpose of this research was to determine the phenotypic spectrum associated with phospholamban gene (PLN) mutations. Inheritance contributes to the development of dilated cardiomyopathy...
  14. Chiu C, Tebo M, Ingles J, Yeates L, Arthur J, Lind J, et al. Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2007;43:337-43 pubmed
    ..for mutations in the Ca(2+) regulatory genes, sorcin (SRI), calstabin (FKBP1B), calsequestrin (CASQ2), phospholamban (PLN), sarcolipin (SLN), calreticulin (CALR3) and calmodulin (CALM)...
  15. Newton Cheh C, Eijgelsheim M, Rice K, de Bakker P, Yin X, Estrada K, et al. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet. 2009;41:399-406 pubmed publisher
    ..5% of the variation in QT interval. These results, together with an accompanying paper, offer insights into myocardial repolarization and suggest candidate genes that could predispose to sudden cardiac death and drug-induced arrhythmias. ..
  16. Posch M, Perrot A, Geier C, Boldt L, Schmidt G, Lehmkuhl H, et al. Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes. Heart Rhythm. 2009;6:480-6 pubmed publisher
    ..phenotypes within a family harboring a familial dilated cardiomyopathy-related mutation in the gene encoding phospholamban. Complete genetic and clinical analyses were performed in a family with familial dilated cardiomyopathy due to ..
  17. Glaves J, Trieber C, Ceholski D, Stokes D, Young H. Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump. J Mol Biol. 2011;405:707-23 pubmed publisher
    b>Phospholamban physically interacts with the sarcoplasmic reticulum calcium pump (SERCA) and regulates contractility of the heart in response to adrenergic stimuli...
  18. Yim J, Cho H, Rabkin S. Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension. Clin Exp Hypertens. 2017;:1-12 pubmed publisher
    ..II receptor Type 1 (AT1R), cytochrome C oxidase I (COX1), fms-like tyrosine kinase 1 (FLT1), TIMP metallopeptidase inhibitor 2 (TIMP2), phospholamban (PLN), vascular cell adhesion molecule 1 (VCAM1), extracellular matrix (ECM).
  19. Matus M, Kucerova D, Kruzliak P, Adameova A, Doka G, Turcekova K, et al. Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat. Mol Cell Biochem. 2015;403:199-208 pubmed publisher
    ..proteins (SERCA2a, cardiac sarco/endoplasmic reticulum Ca(2+)-ATPase; CSQ, calsequestrin; TRD, triadin; PLB, phospholamban; Thr(17)-PLB-phosphorylated PLB at threonine-17, FKBP12.6, FK506-binding protein, Cav1...
  20. Santos G, Oliveira E, Pinheiro A, da Costa P, de Freitas J, de Araújo Santos F, et al. Himatanthus drasticus (Apocynaceae) latex reduces oxidative stress and modulates CD4+, CD8+, FoxP3+ and HSP-60+ expressions in Sarcoma 180-bearing mice. J Ethnopharmacol. 2018;220:159-168 pubmed publisher
    ..Present data emphasizes the importance of immune system in cancer and highlights the evaluation of the pharmacological properties of plants used by population as phytoterapics. ..
  21. Qiu Z, Zhang W, Fan F, Li H, Wu C, Ye Y, et al. Rosuvastatin-attenuated heart failure in aged spontaneously hypertensive rats via PKCα/β2 signal pathway. J Cell Mol Med. 2012;16:3052-61 pubmed publisher
    ..activity and mitochondria cytochrome C oxidase (CCO) activity were measured; the expressions of SERCA-2a, phospholamban (PLB), ryanodine receptor2 (RyR2), sodium-calcium exchanger 1 (NCX1), Ca(2+)/calmodulin-dependent protein ..
  22. Soares A, Horie N, Chiang L, Caramelli B, Matheus M, Campos A, et al. Effects of clomiphene citrate on male obesity-associated hypogonadism: a randomized, double-blind, placebo-controlled study. Int J Obes (Lond). 2018;42:953-963 pubmed publisher
    ..Random allocation to receive 50 mg CC or placebo (PLB) for 12 weeks...
  23. Ellison M, Gearheart C, Porter C, Ambruso D. IFN-? alters the expression of diverse immunity related genes in a cell culture model designed to represent maturing neutrophils. PLoS ONE. 2017;12:e0185956 pubmed publisher
    ..To explore this possibility we made use of PLB-985 cells, a myeloblast-like myeloid cell line that can be differentiated into a mature, neutrophil-like state by ..
  24. Warbrick I, Rabkin S. Effect of the peptides Relaxin, Neuregulin, Ghrelin and Glucagon-like peptide-1, on cardiomyocyte factors involved in the molecular mechanisms leading to diastolic dysfunction and/or heart failure with preserved ejection fraction. Peptides. 2019;111:33-41 pubmed publisher
    ..b>Phospholamban (PLB), in the SR and endoplasmic reticulum, is the primary regulator of SERCA2a in the heart and acts as a ..
  25. Jia Y, Chang H, Schipma M, Liu J, Shete V, Liu N, et al. Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice. PLoS ONE. 2016;11:e0160755 pubmed publisher
  26. Eijgelsheim M, Newton Cheh C, Sotoodehnia N, de Bakker P, Müller M, Morrison A, et al. Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 2010;19:3885-94 pubmed publisher
    ..6%, suggesting that some loci falling short of genome-wide significance are likely truly associated. Future research is warranted to elucidate underlying mechanisms that may impact clinical care. ..
  27. Groeneweg J, van der Zwaag P, Olde Nordkamp L, Bikker H, Jongbloed J, Jongbloed R, et al. Arrhythmogenic right ventricular dysplasia/cardiomyopathy according to revised 2010 task force criteria with inclusion of non-desmosomal phospholamban mutation carriers. Am J Cardiol. 2013;112:1197-206 pubmed publisher
    ..However, nondesmosomal mutations may be involved. The aim of this study was to assess the contribution of a phospholamban (PLN) gene mutation to ARVD/C diagnosis according to the revised 2010 task force criteria (TFC)...
  28. Dalpiaz P, Lamas A, Caliman I, Ribeiro R, Abreu G, Moyses M, et al. Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats. PLoS ONE. 2015;10:e0127515 pubmed publisher
    ..Gonadectomy increased protein expression of PLB (phospholamban) and the PLB to SERCA2a ratio in female rats, but did not change in male rats...
  29. Wagner M, Weber S, El Armouche A. Linking superinhibitory PLN mutations to CaMKII activation: a new arrhythmogenic mechanism in genetic DCM?. Cardiovasc Res. 2015;107:5-6 pubmed publisher
  30. Fajardo V, Bombardier E, McMillan E, TRAN K, Wadsworth B, Gamu D, et al. Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype. Dis Model Mech. 2015;8:999-1009 pubmed publisher
    ..Here, we obtained commercially available mice overexpressing phospholamban (Pln(OE)), a well-known inhibitor of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs), in their slow-..
  31. Espinasse M, Pépin A, Virault Rocroy P, Szely N, Chollet Martin S, Pallardy M, et al. Glucocorticoid-Induced Leucine Zipper Is Expressed in Human Neutrophils and Promotes Apoptosis through Mcl-1 Down-Regulation. J Innate Immun. 2016;8:81-96 pubmed publisher
    ..We then stably transfected PLB-985 cells with the human gilz gene and differentiated both control and GILZ-overexpressing clones in neutrophil-..
  32. Bobin P, Varin A, Lefebvre F, Fischmeister R, Vandecasteele G, Leroy J. Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors. Cardiovasc Res. 2016;110:151-61 pubmed publisher
    ..PDE4 inhibition potentiated RyR2 and PLB phosphorylation at specific PKA and CaMKII sites increasing sarcoplasmic reticulum (SR) Ca(2+) load and SR Ca(2+) ..
  33. Tsaplina O, Khaitlina S. Sodium fluoride as a nucleating factor for Mg-actin polymerization. Biochem Biophys Res Commun. 2016;479:741-746 pubmed publisher
    ..These data suggest that the NaF-induced assembly of actin filaments is promoted by magnesium fluoride that can be formed by the NaF-originating fluoride and the actin tightly bound magnesium. ..
  34. Kim J, Ramasamy T, Choi J, Kim S, Youn Y, Choi H, et al. PEGylated polypeptide lipid nanocapsules to enhance the anticancer efficacy of erlotinib in non-small cell lung cancer. Colloids Surf B Biointerfaces. 2017;150:393-401 pubmed publisher
    ..ERL-PLN-treated mice showed 5- and 2-fold smaller tumor volume compared to control and free ERL groups, respectively. Based on these results, PLN provide a promising drug delivery approach for lung cancer therapy. ..
  35. Na S, Zhang J, Zhou X, Tang A, Huang D, Xu Q, et al. Plumbagin mediating GLUT1 suppresses the growth of human tongue squamous cell cancer. Oral Dis. 2017;: pubmed publisher
    The purpose of this study is to investigate the clinical and histopathological characteristics of GLUT1 in human tongue squamous cell carcinoma (TSCC) and the role of Plumbagin (PLB) mediating GLUT1 in the growth of TSCC.
  36. Bidwell P, Haghighi K, Kranias E. The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart. J Biol Chem. 2018;293:359-367 pubmed publisher
    ..X-1) localizes to sarcoplasmic reticulum (SR) in the heart and interacts with the small membrane protein phospholamban (PLN), inhibiting the cardiac sarco/endoplasmic reticulum calcium ATPase 2a (SERCA2a) in the regulation of ..
  37. Nadrowski P, Podolecka E, Pajak A, Dorynska A, Drygas W, Bielecki W, et al. How does the risk of cardiovascular death and cardiovascular risk factor profiles differ between socioeconomic classes in Poland: A country in transition. Cardiol J. 2018;: pubmed publisher
    ..It may reflect a transition being undergone in Poland, moreover, it predicts how socioeconomic factors may generate health inequalities in other transitioning countries. ..
  38. Webster K, Bishopric N. Molecular aspects and gene therapy prospects for diastolic failure. Cardiol Clin. 2000;18:621-35 pubmed
    ..b>PLB and cTnI also are attractive targets but only if molecular techniques can be devised to modulate their activity ..
  39. Kim J, Masterson L, Cembran A, Verardi R, Shi L, Gao J, et al. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proc Natl Acad Sci U S A. 2015;112:3716-21 pubmed publisher
    ..of two complexes of the catalytic subunit of the cAMP-dependent protein kinase A with WT and R14 deletion phospholamban, a lethal human mutant linked to familial dilated cardiomyopathy...
  40. Marston S, Montgiraud C, Munster A, Copeland O, Choi O, dos Remedios C, et al. OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency. PLoS ONE. 2015;10:e0138568 pubmed publisher
    ..were 6 truncating mutations in TTN, 3 mutations in MYH7, 2 in DSP and one each in TNNC1, TNNI3, MYOM1, VCL, GLA, PLB, TCAP, PKP2 and LAMA4...
  41. Chisholm K, Ohgami R, Tan B, Hasserjian R, Weinberg O. Primary lymphoma of bone in the pediatric and young adult population. Hum Pathol. 2017;60:1-10 pubmed publisher
    Primary lymphoma of bone (PLB) accounts for 3% to 7% of primary neoplasms of bone and must be distinguished from more common bone tumors in the pediatric population such as osteosarcoma, Ewing sarcoma, and other small round blue cell ..
  42. Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamás K, Hadgraft N, Martin E, et al. Disulfide-activated protein kinase G I? regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response. Nat Commun. 2016;7:13187 pubmed publisher
    ..G I? (PKGI?) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16-a site important for diastolic relaxation...
  43. Avery C, Wassel C, Richard M, Highland H, Bien S, Zubair N, et al. Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations. Heart Rhythm. 2017;14:572-580 pubmed publisher
  44. Tanwar V, Adelstein J, Grimmer J, Youtz D, Sugar B, Wold L. PM2.5 exposure in utero contributes to neonatal cardiac dysfunction in mice. Environ Pollut. 2017;230:116-124 pubmed publisher
    ..These data demonstrated that exposure to PM2.5 during the gestation period significantly impacts cardiovascular outcomes early in life. ..
  45. Fajardo V, Smith I, Bombardier E, Chambers P, Quadrilatero J, Tupling A. Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers. Brain Behav. 2016;6:e00470 pubmed publisher
    b>Phospholamban (PLN) and sarcolipin (SLN) are small inhibitory proteins that regulate the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) pump...
  46. Bai T, Hu X, Zheng Y, Wang S, Kong J, Cai L. Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomerization. Am J Physiol Heart Circ Physiol. 2016;311:H1051-H1062 pubmed publisher
    ..markers for cardiac inflammation, cell death, and oxidative stress, SERCA2a activity, and the ratios of phospholamban (PLB) monomer to oligomer were measured...
  47. Osman S, Jeevanandam P, Kanakavelu N, Irvine D, Lyons C, Jain S, et al. Class solutions for SABR-VMAT for high-risk prostate cancer with and without elective nodal irradiation. Radiat Oncol. 2016;11:155 pubmed
    ..Class solutions using a single 10 F 300° arc for PO and two 10 F or 6 F partial 300° arcs for PPLN are proposed. ..
  48. Greisch J, Chmela J, Harding M, Wunderlich D, Schäfer B, Ruben M, et al. Correlation of the structural information obtained for europium-chelate ensembles from gas-phase photoluminescence and ion-mobility spectroscopy with density-functional computations and ligand-field theory. Phys Chem Chem Phys. 2017;19:6105-6112 pubmed publisher
    ..The present work demonstrates the complexity of the coordination patterns of multicenter lanthanoid chelates involved in dynamical equilibria and the pertinence of using isolation techniques to elucidate their photophysical properties. ..
  49. Geiss A, Bliem C, Frank P, Reiner Rozman C, Kewney J, Boersch M, et al. Proteo-lipobeads to encapsulate cytochrome c oxidase from Paracoccus denitrificans. J Colloid Interface Sci. 2017;500:119-125 pubmed publisher
    ..In this orientation the P side of CcO faces the outside of the PLB and hence protons are released to the outer aqueous phase, when electron transfer is initiated by light excitation ..
  50. Pasztoi M, Pezoldt J, Beckstette M, Lipps C, Wirth D, Rohde M, et al. Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells. Eur J Immunol. 2017;47:2142-2152 pubmed publisher
    ..This finding provides novel insights into the subcellular/molecular mechanisms of de novo Treg induction and might serve as promising tool for future therapeutic applications to treat inflammatory disorders...
  51. Zhang W, Zhou L, Dang J, Zhang X, Wang J, Chen Y, et al. Human Gingiva-Derived Mesenchymal Stem Cells Ameliorate Streptozoticin-induced T1DM in mice via Suppression of T effector cells and Up-regulating Treg Subsets. Sci Rep. 2017;7:15249 pubmed publisher
    ..Mechanismly, GMSCs could migrate to pancreas and local lymph node and function through CD39/CD73 pathway to regulate effector T cells. Thus, GMSCs show a potential promise in treating T1DM in the clinic. ..
  52. Fernandes A, Faria T, Ribeiro Júnior R, Costa G, Marchezini B, Silveira E, et al. A single resistance exercise session improves myocardial contractility in spontaneously hypertensive rats. Braz J Med Biol Res. 2015;48:813-21 pubmed publisher
    ..SERCA2a, phospholamban (PLB), and phosphorylated PLB expression were investigated by Western blot...
  53. Tang J, Guo Y, Yu X, Huang W, Zheng M, Zhou Y, et al. CD147 reinforces [Ca2+]i oscillations and promotes oncogenic progression in hepatocellular carcinoma. Oncotarget. 2015;6:34831-45 pubmed publisher
    ..accelerates ER Ca2+refilling and enhances the frequency of [Ca2+]i oscillations through activating CaMKP-PAK1-PP2A-PLB-SERCA signaling pathway...
  54. Hammoudi N, Jeong D, Singh R, Farhat A, Komajda M, Mayoux E, et al. Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a Genetic Model of Type 2 Diabetes. Cardiovasc Drugs Ther. 2017;31:233-246 pubmed publisher
    ..This was paralleled by an increase in phospholamban (PLN) phosphorylation and increased SERCA2a/PLN ratio, indicative of enhanced SERCA2a function, further ..
  55. Nakamura K, Koga H, Sekiya I, Watanabe T, Mochizuki T, Horie M, et al. Dynamic Evaluation of Pivot-Shift Phenomenon in Double-Bundle Anterior Cruciate Ligament Reconstruction Using Triaxial Accelerometer. Arthroscopy. 2016;32:2532-2538 pubmed publisher
    ..MRT) based on the pivot-shift phenomenon in isolated anteromedial bundle (AMB), isolated posteromedial bundle (PLB), and double-bundle anterior cruciate ligament (ACL) reconstructions using a triaxial accelerometer during surgery...
  56. Benito V, Carballo S, Silva P, Esparza M, Arencibia O, Federico M, et al. Should the Presence of Metastatic Para-Aortic Lymph Nodes in Locally Advanced Cervical Cancer Lead to More Aggressive Treatment Strategies?. J Minim Invasive Gynecol. 2017;24:609-616 pubmed publisher
    ..Efforts should be made to improve available therapeutic strategies for this particular subgroup of patients. ..
  57. Wang L, Luo H, Qin G, Cao Y, Gao X, Zhang Z, et al. The Impact of Sevoflurane on Coupling of the Left Ventricular-to-Systemic Vasculature in Rats With Chronic Pulmonary Hypertension. J Cardiothorac Vasc Anesth. 2017;31:2027-2034 pubmed publisher
    ..Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) level was decreased and the expression of phospholamban (PLB) was increased in the PH group and after sevoflurane treatment...
  58. Tran V, Ngo H, Guo W, Ton That C, Li J, Li J, et al. Removal of antibiotics (sulfamethazine, tetracycline and chloramphenicol) from aqueous solution by raw and nitrogen plasma modified steel shavings. Sci Total Environ. 2017;601-602:845-856 pubmed publisher
  59. Lezcano N, Mariángelo J, Vittone L, Wehrens X, Said M, Mundina Weilenmann C. Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes. J Mol Cell Cardiol. 2018;114:1-9 pubmed publisher
    ..frequency and enhanced CaMKII autophosphorylation and the CaMKII-dependent phosphorylation of SR proteins: phospholamban (PLN, at Thr17 site) and ryanodine receptor (RyR2, at Ser2814 site)...
  60. Boknik P, Khorchidi S, Bodor G, Huke S, Knapp J, Linck B, et al. Role of protein phosphatases in regulation of cardiac inotropy and relaxation. Am J Physiol Heart Circ Physiol. 2001;280:H786-94 pubmed
    ..phosphorylation of the inhibitory subunit of troponin (TnI-P) and with the site-specific phosphorylation of phospholamban (PLB) at serine-16 (PLB-Ser-16) and threonine-17 (PLB-Thr-17)...
  61. Hirtle Lewis M, Desbiens K, Ruel I, Rudzicz N, Genest J, Engert J, et al. The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN. Clin Cardiol. 2013;36:628-33 pubmed publisher
    ..4 previously identified genes: lamin A/C (LMNA), cardiac troponin T type 2 (TNNT2), titin-cap (TCAP), and phospholamban (PLN)...
  62. Rain S, Bós D, Handoko M, Westerhof N, Stienen G, Ottenheijm C, et al. Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension. J Am Heart Assoc. 2014;3:e000716 pubmed publisher
    ..antibodies to protein-kinase-A (PKA), C? (PKC?) and Ca(2+)/calmoduling-dependent-kinase (CamKII?) titin and phospholamban (PLN) phosphorylation sites: N2B (Ser469), PEVK (Ser170 and Ser26), and PLN (Thr17), respectively...
  63. Smeazzetto S, Sacconi A, Schwan A, Margheri G, Tadini Buoninsegni F. Binding of a monoclonal antibody to the phospholamban cytoplasmic domain interferes with the channel activity of phospholamban reconstituted in a tethered bilayer lipid membrane. Langmuir. 2014;30:10384-8 pubmed publisher
    b>Phospholamban (PLN), a membrane protein present in the sarcoplasmic reticulum of cardiac myocytes, is a crucial regulator of cardiac function. It is known that PLN appears as a monomer and as a pentamer...
  64. Behr E, Savio Galimberti E, Barc J, Holst A, Petropoulou E, Prins B, et al. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovasc Res. 2015;106:520-9 pubmed publisher
    ..The common SNP SCN10A V1073 was strongly associated with BrS and demonstrated loss of NaV1.8 function, as did rare variants in isolated patients. ..
  65. Stammers A, Susser S, Hamm N, Hlynsky M, Kimber D, Kehler D, et al. The regulation of sarco(endo)plasmic reticulum calcium-ATPases (SERCA). Can J Physiol Pharmacol. 2015;93:843-54 pubmed publisher
    ..of SERCA is regulated at the level of protein content and is further modified by the endogenous proteins phospholamban (PLN) and sarcolipin (SLN)...
  66. Tewari D, Bera A. Modulation of the voltage-dependent anion channel of mitochondria by elaidic acid. Biochem Biophys Res Commun. 2016;477:490-4 pubmed publisher
    ..Purified bovine brain VDAC, when incorporated in the planar lipid bilayer (PLB) composed of 1,2-diphytanoyl-sn-glycero-3 phosphatidyl choline (DPhPC) and EA in a 9 to 1 ratio (wt/wt), exhibited ..
  67. Li S, Huang H, Zhang M, Wang W, Xue S, Gao Y, et al. Liguzinediol Enhances the Inotropic Effect of Rat Hearts via Inhibition of Protein Phosphatase (PP1 and PP2A) Activities. J Cardiovasc Pharmacol. 2017;69:236-244 pubmed publisher
    ..and Western blot techniques were used to analyze the rat heart contractility, and SERCA2a activity, phospholamban (PLB) phosphorylation, and protein phosphatase (PP1 and PP2A) activities in rat left ventricular myocytes, ..
  68. Durán J, Lagos D, Pávez M, Troncoso M, Ramos S, Barrientos G, et al. Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy. Front Pharmacol. 2017;8:604 pubmed publisher
    ..Moreover, western blotting was used to assess CaMKII and phospholamban (PLN) phosphorylation, and MEF2C and AR protein levels in extracts of left-ventricle tissue from control and ..
  69. McTiernan C, Frye C, Lemster B, Kinder E, Ogletree Hughes M, Moravec C, et al. The human phospholamban gene: structure and expression. J Mol Cell Cardiol. 1999;31:679-92 pubmed
    b>Phospholamban, through modulation of sarcoplasmic reticulum calcium-ATPase activity, is a key regulator of cardiac diastolic function. Alterations in phospholamban expression may define parameters of muscle relaxation...
  70. Fischer H, Fischer J, Boknik P, Gergs U, Schmitz W, Domschke W, et al. Reduced expression of Ca2+-regulating proteins in the upper gastrointestinal tract of patients with achalasia. World J Gastroenterol. 2006;12:6002-7 pubmed
    ..Sarcoplasmic reticulum Ca(2+) ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus ..
  71. Thomassen M, Gunnarsson T, Christensen P, Pavlovic D, Shattock M, Bangsbo J. Intensive training and reduced volume increases muscle FXYD1 expression and phosphorylation at rest and during exercise in athletes. Am J Physiol Regul Integr Comp Physiol. 2016;310:R659-69 pubmed publisher
    ..Expression of FXYD1 (30%), actin (40%), mammalian target of rapamycin (mTOR) (12%), phospholamban (PLN) (16%), and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) γ/δ (25%) was higher (P < 0...
  72. Tian S, Silverman E, Pullenayegum E, Brown P, Beyene J, Feldman B. Comparative Effectiveness of Mycophenolate Mofetil for the Treatment of Juvenile-Onset Proliferative Lupus Nephritis. Arthritis Care Res (Hoboken). 2017;69:1887-1894 pubmed publisher
    ..Marginal structural models enable us to estimate treatment effectiveness using observational data while accounting for confounding by indication...
  73. Tsai C, Kuo W, Shibu M, Lin Y, Liu C, Chen Y, et al. E2/ER ? inhibit ISO-induced cardiac cellular hypertrophy by suppressing Ca2+-calcineurin signaling. PLoS ONE. 2017;12:e0184153 pubmed publisher
    ..blocked suggesting that E2/ER? inhibited calcineurin activity to activate I-1 protein and suppress PP1, then induce PLB protein phosphorylation and activation, resulting in Ca2+ reuptake into sarcoplasmic reticulum through SR Ca2+ ..
  74. Sezgin O, Yaraş S, Ates F, Altintas E, Saritas B. Effectiveness of Sedoanalgesia in Percutaneous Liver Biopsy Premedication. Euroasian J Hepatogastroenterol. 2017;7:146-149 pubmed publisher
    Percutaneous needle liver biopsy (PLB) is frequently associated with pain and anxiety. This may discourage the patients for biopsy, and rebiopsies, if needed...
  75. Kadambi V, Kranias E. Phospholamban: a protein coming of age. Biochem Biophys Res Commun. 1997;239:1-5 pubmed
    b>Phospholamban is a major regulator of the kinetics of cardiac contractility, through its ability to regulate the function of the cardiac SR Ca(2+)-pump and thus the SR Ca2+ load...
  76. Pollesello P, Annila A. Structure of the 1-36 N-terminal fragment of human phospholamban phosphorylated at Ser-16 and Thr-17. Biophys J. 2002;83:484-90 pubmed
    The structure of a 36-amino-acid-long N-terminal fragment of human phospholamban phosphorylated at Ser-16 and Thr-17 and Cys-36-->Ser mutated was determined from nuclear magnetic resonance data in aqueous solution containing 30% ..
  77. Chen Z. Competitive displacement of wild-type phospholamban from the Ca2+-free cardiac calcium pump by phospholamban mutants with different binding affinities. J Mol Cell Cardiol. 2014;76:130-7 pubmed publisher
    b>Phospholamban (PLB) regulates the cardiac Ca(2+) pump (SERCA2a)...
  78. Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, et al. Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nat Commun. 2015;6:6955 pubmed publisher
    A number of genetic mutations is associated with cardiomyopathies. A mutation in the coding region of the phospholamban (PLN) gene (R14del) is identified in families with hereditary heart failure...
  79. Shaikh S, Sahoo S, Periasamy M. Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?. J Mol Cell Cardiol. 2016;91:81-91 pubmed publisher
    In muscle, the Sarco(Endo)plasmic Reticulum Calcium ATPase (SERCA) activity is regulated by two distinct proteins, PLB and SLN, which are highly conserved throughout vertebrate evolution...
  80. Asahi M, Kimura Y, Kurzydlowski K, Tada M, MacLennan D. Transmembrane helix M6 in sarco(endo)plasmic reticulum Ca(2+)-ATPase forms a functional interaction site with phospholamban. Evidence for physical interactions at other sites. J Biol Chem. 1999;274:32855-62 pubmed
    ..and MacLennan, D. H. (1997) J. Biol. Chem. 272, 15061-15064), mutation of amino acids on one face of the phospholamban (PLN) transmembrane helix led to loss of PLN inhibition of sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) ..
  81. Asahi M, Green N, Kurzydlowski K, Tada M, MacLennan D. Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases. Proc Natl Acad Sci U S A. 2001;98:10061-6 pubmed
    ..M6 of the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) has been shown to form a site of interaction with phospholamban (PLN)...
  82. Møller D, Pham T, Gustafsson F, Hedley P, Ersbøll M, Bundgaard H, et al. The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy. Eur J Heart Fail. 2009;11:1031-5 pubmed publisher
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    b>Phospholamban (PLN) is a single-pass membrane protein that regulates the sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA)...
  84. Liu G, Morales A, Vafiadaki E, Lam C, Cai W, Haghighi K, et al. A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia. Cardiovasc Res. 2015;107:164-74 pubmed publisher
  85. Yang C, Yin X, Dong X, Zhang X, You L, Wang W, et al. Determination of the phytochemical composition of Jingning fang and the in vivo pharmacokinetics of its metabolites in rat plasma by UPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1067:71-88 pubmed publisher
    ..These findings are useful for predicting the bioactive components of JNF, and will aid in optimizing dose regimens of the drug...
  86. Pecoraro M, Rodriguez Sinovas A, Marzocco S, Ciccarelli M, Iaccarino G, Pinto A, et al. Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment. Int J Mol Sci. 2017;18: pubmed publisher
    ..Sarco/endoplasmic reticulum Ca2+-ATPase (SERCAII) and phospholamban (PLB) expression were assessed by Western blot analysis, intracellular [Ca2+] were detected ..
  87. Jia L, Shan K, Pan L, Feng N, Lv Z, Sun Y, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017;8:1345 pubmed publisher
    ..Our results provide the basis for future clinical investigations in preventing type 1 diabetes by oral CB0313.1 administration...
  88. Hou Z, Kelly E, Robia S. Phosphomimetic mutations increase phospholamban oligomerization and alter the structure of its regulatory complex. J Biol Chem. 2008;283:28996-9003 pubmed publisher
    To investigate the effect of phosphorylation on the interactions of phospholamban (PLB) with itself and its regulatory target, SERCA, we measured FRET from CFP-SERCA or CFP-PLB to YFP-PLB in live AAV-293 cells...
  89. Sharma P, Ignatchenko V, Grace K, Ursprung C, Kislinger T, Gramolini A. Endoplasmic reticulum protein targeting of phospholamban: a common role for an N-terminal di-arginine motif in ER retention?. PLoS ONE. 2010;5:e11496 pubmed publisher
    b>Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase, which transports Ca(2+) into the SR lumen, leading to muscle relaxation...
  90. Zhang Y, Jin C, Jang J, Wang Y. Molecular mechanisms of neuronal nitric oxide synthase in cardiac function and pathophysiology. J Physiol. 2014;592:3189-200 pubmed publisher
    ..g. PKA-dependent phospholamban phosphorylation (PLN-Ser(16))] in the healthy heart to cGMP/PKG-dependent PLN-Ser(16) with acute angiotensin ..
  91. Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater Lleal M, Lengquist M, Miller C, et al. Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. Arterioscler Thromb Vasc Biol. 2016;36:1947-61 pubmed publisher
    ..We identified a panel of genes that reflect the altered phenotype of SMCs in vascular disease and could be early sensitive markers of SMC dedifferentiation. ..