Gene Symbol: PHF19
Description: PHD finger protein 19
Alias: MTF2L1, PCL3, TDRD19B, PHD finger protein 19, polycomb like 3, polycomb-like protein 3, tudor domain containing 19B
Species: human
Products:     PHF19

Top Publications

  1. Wang S, Robertson G, Zhu J. A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers. Gene. 2004;343:69-78 pubmed
    ..Thus, our data link PcG deregulation to the progression of multiple cancers and may have important implications for unraveling the mechanisms of tumor progression. ..
  2. Gregersen P, Amos C, Lee A, Lu Y, Remmers E, Kastner D, et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet. 2009;41:820-3 pubmed publisher
  3. Weller S, Schlindwein S, Feil C, Kelemen Z, Buzsáki D, Nyulaszi L, et al. Controllable access to P-functional [3]ferrocenophane and [4]ferrocenophane frameworks. Dalton Trans. 2019;: pubmed publisher
    Condensation of secondary 1,1'-diaminoferrocenes with phosphorus trihalides (PCl3 or PBr3) yielded either P-halo-1,3-diaza-2-phospha[3]ferrocenophanes or 1,1'-diaminoferrocenediyl-bis(dichlorophosphines), respectively...
  4. Frogley B, Hill A. Alkynylbis(alkylidynyl)phosphines: {LnM[triple bond, length as m-dash]C}2PC[triple bond, length as m-dash]CR. Chem Commun (Camb). 2018;54:12373-12376 pubmed publisher
    ..Alternatively, treating [W([triple bond, length as m-dash]CBr)(CO)2(Tp*)] with nBuLi, 1/2 PCl3 and LiC[triple bond, length as m-dash]CR' affords the alkynylbis(alkylidynyl)phosphines [R'C[triple bond, length as ..
  5. Deng Q, Hou J, Feng L, Lv A, Ke X, Liang H, et al. PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis. Cell Death Dis. 2018;9:1049 pubmed publisher
    b>PHD finger protein 19 (PHF19), a critical component of the polycomb repressive complex 2 (PRC2), is crucial for maintaining the repressive transcriptional activity of several developmental regulatory genes and plays essential roles in ..
  6. Otang M, Josephson D, Duppong T, Stahl L. The chameleonic reactivity of dilithio bis(alkylamido)cyclodiphosph(iii)azanes with chlorophosphines. Dalton Trans. 2018;: pubmed publisher
    ..or dilithio bis(tert-butylamido)cyclodisilazane was treated with two equivalents of PCl3. In each case only the symmetrically N,N'-substituted bis(PCl2) product was obtained and characterized by X-ray ..
  7. Donath M, Bodensteiner M, Weigand J. Versatile reagent Ph3 As(OTf)2: one-pot synthesis of [P7(AsPh3)3][OTf]3 from PCl3. Chemistry. 2014;20:17306-10 pubmed publisher
    ..It also represents a stronger chloride-abstracting agent than Me3 SiOTf and facilitates the reductive coupling of PCl3 in the presence of AsPh3 to the unprecedented cation [P7 (AsPh3 )3](3+) as triflate salt...
  8. Böttcher T, Steinhauer S, Lewis Alleyne L, Neumann B, Stammler H, Bassil B, et al. NHC→SiCl4 : an ambivalent carbene-transfer reagent. Chemistry. 2015;21:893-9 pubmed publisher
    ..Furthermore, the reactivity of NHC→SiCl4 towards phosphines is discussed. The carbene complex NHC→PCl3 shows similar reactivity to NHC→SiCl4 , and may even serve as a carbene-transfer reagent as well.
  9. Lu J, Ji H, Tang H, Xu Z. microRNA-124a suppresses PHF19 over-expression, EZH2 hyper-activation, and aberrant cell proliferation in human glioma. Biochem Biophys Res Commun. 2018;503:1610-1617 pubmed publisher
    ..Here, we examined the role of the lesser-known PRC2-associated PHD Finger Protein 19 (PHF19) in human glioma...

More Information


  1. Sidiropoulos A, Osborne B, Simonov A, Dange D, Bond A, Stasch A, et al. Expanded ring N-heterocyclic carbene adducts of group 15 element trichlorides: synthesis and reduction studies. Dalton Trans. 2014;43:14858-64 pubmed publisher
    ..Reduction of [(6-Dip)PCl3] with KC8 yielded the unusual tetraphosphorus dicationic complex, [(6-Dip)2(μ-P4)]Cl2, the X-ray crystal ..
  2. Gatchalian J, Kingsley M, Moslet S, Rosas Ospina R, Kutateladze T. An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3. Epigenetics. 2015;10:467-73 pubmed publisher
    ..The Tudor domains of human homologs PHF1 and PHF19 have been found to recognize trimethylated lysine 36 of histone H3 (H3K36me3); however, the biological role of ..
  3. Bentlohner M, Waibel M, Zeller P, Sarkar K, Müller Buschbaum P, Fattakhova Rohlfing D, et al. Zintl Clusters as Wet-Chemical Precursors for Germanium Nanomorphologies with Tunable Composition. Angew Chem Int Ed Engl. 2016;55:2441-5 pubmed publisher
    ..method is based on the assembly and oxidation of [Ge9 ](4-) clusters in a template mold using SiCl4 , GeCl4 , and PCl3 leading to Si and P-containing Ge phases as shown by X-ray diffraction, Raman spectroscopy, and energy-dispersive X-..
  4. Ramanathan N, Sankaran K, Sundararajan K. PCl3-C6H6 heterodimers: evidence for P? phosphorus bonding at low temperatures. Phys Chem Chem Phys. 2016;18:19350-8 pubmed publisher
    A phosphorous trichloride (PCl3)-benzene (C6H6) heterodimer was generated in a low temperature N2 matrix and was characterized using infrared spectroscopy...
  5. Brien G, Healy E, Jerman E, Conway E, Fadda E, O Donovan D, et al. A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence. Genes Dev. 2015;29:2231-43 pubmed publisher
    ..We show that while PCL2 and PCL3 are E2F-regulated genes expressed in proliferating cells, PCL1 is a p53 target gene predominantly expressed in ..
  6. Chen S, Jiao L, Shubbar M, Yang X, Liu X. Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol Cell. 2018;69:840-852.e5 pubmed publisher
    ..Aebp2 and Phf19 compete for binding of a non-canonical C2 domain of Suz12; Jarid2 and EPOP occupy an overlapped Suz12 surface ..
  7. Gollavilli P, Pawar A, Wilder Romans K, Natesan R, Engelke C, Dommeti V, et al. EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins. Cancer Res. 2018;78:4760-4773 pubmed publisher
    ..Polycomb repressive complex 2 (PRC2)-associated factor PHF19 was downregulated by JQ1/BETd or BRD4 knockdown in multiple EWS lines...
  8. Asami S, Okamoto M, Suzuki K, Yamashita M. A Boryl-Substituted Diphosphene: Synthesis, Structure, and Reaction with n-Butyllithium To Form a Stabilized Adduct by p?-p? Interaction. Angew Chem Int Ed Engl. 2016;55:12827-31 pubmed publisher
    A boryl-substituted diphosphene was synthesized through the nucleophilic borylation of PCl3 with a borylzinc reagent, followed by a reduction with Mg...
  9. Cai L, Rothbart S, Lu R, Xu B, Chen W, Tripathy A, et al. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell. 2013;49:571-82 pubmed publisher
    ..binding activity is harbored in the Tudor motifs of PRC2-associated polycomb-like (PCL) proteins PHF1/PCL1 and PHF19/PCL3...
  10. Qin S, Guo Y, Xu C, Bian C, Fu M, Gong S, et al. Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3. Biochem Biophys Res Commun. 2013;430:547-53 pubmed publisher
    ..In this study, we focused on characterizing the histone binding domains of PHF1 and PHF19, and found that the Tudor domains of PHF1 and PHF19 selectively bind to histone H3K36me3...
  11. Ghislin S, Deshayes F, Middendorp S, Boggetto N, Alcaide Loridan C. PHF19 and Akt control the switch between proliferative and invasive states in melanoma. Cell Cycle. 2012;11:1634-45 pubmed publisher
    ..three-dimensional cultures revealed the downregulation of a polycomb-like protein, PHF19 (PHD finger protein 19), in the spheroids...
  12. Xu H, Hu Y, Zhao J, Hu X, Li S, Wang Y, et al. MicroRNA-195-5p acts as an anti-oncogene by targeting PHF19 in hepatocellular carcinoma. Oncol Rep. 2015;34:175-82 pubmed publisher
    Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. PHD finger protein 19 (PHF19) encodes a member of the polycomb group (PcG) of proteins that functions by maintaining the repressive transcriptional states of ..
  13. Pan M, Hsu M, Chen L, Hung W. G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation. Sci Rep. 2015;5:18709 pubmed publisher
    ..G9a promotes H3K27 methylation of the E-cadherin promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase KDM7A to silence E-cadherin gene...
  14. Jiang L, Yin J, Ye L, Yang J, Hemani G, Liu A, et al. Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. Arthritis Rheumatol. 2014;66:1121-32 pubmed publisher
  15. Crossland H, Atherton P, Stromberg A, Gustafsson T, Timmons J. A reverse genetics cell-based evaluation of genes linked to healthy human tissue age. FASEB J. 2017;31:96-108 pubmed publisher
    ..Potential epigenetic interactions included HIST1H3E knockdown, leading to decreased PHF19 and PCDH9, and increased ICAM5 in muscle and renal cells, while ICAM5 knockdown reduced HIST1H3E expression...
  16. Jung H, Kang J, Chun H, Han B. First principles computational study on hydrolysis of hazardous chemicals phosphorus trichloride and oxychloride (PCl3 and POCl3) catalyzed by molecular water clusters. J Hazard Mater. 2018;341:457-463 pubmed publisher
    ..It is ascribed to the unique double-bonding O=P in the POCl3. Our results on the activation free energy show well agreements with previous experimental data within 7kcalmol-1 deviation. ..
  17. Zhernakova A, Stahl E, Trynka G, Raychaudhuri S, Festen E, Franke L, et al. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet. 2011;7:e1002004 pubmed publisher
  18. Boulay G, Rosnoblet C, Guerardel C, Angrand P, Leprince D. Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes. Biochem J. 2011;434:333-42 pubmed publisher
    ..Our results provide the first evidence that the two hPCL3 isoforms belong to different complexes and raise important questions about their relative functions, particularly in tumorigenesis. ..
  19. Krátký M, Stepánková S, Vorčáková K, Vinsova J. Synthesis and in vitro evaluation of novel rhodanine derivatives as potential cholinesterase inhibitors. Bioorg Chem. 2016;68:23-9 pubmed publisher
    ..amides and esters of 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid (rhodanine-3-acetic acid) via carbodiimide- or PCl3-mediated coupling...
  20. Dubey N, Hoffman J, Schuebel K, Yuan Q, Martinez P, Nieman L, et al. The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. Mol Psychiatry. 2017;22:1172-1184 pubmed publisher
    ..more than half of these genes over-expressed as compared with the controls, and with significant effects for MTF2, PHF19 and SIRT1 (P<0.05). RNA and protein expression of the 13 ESC/E(Z) complex genes were individually quantitated...
  21. Li H, Liefke R, Jiang J, Kurland J, Tian W, Deng P, et al. Polycomb-like proteins link the PRC2 complex to CpG islands. Nature. 2017;549:287-291 pubmed publisher
    ..Polycomb-like (PCL) proteins, such as PHF1, MTF2 and PHF19, are PRC2-associated factors that form sub-complexes with PRC2 core components, and have been proposed to modulate ..
  22. Brien G, Gambero G, O Connell D, Jerman E, Turner S, Egan C, et al. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. Nat Struct Mol Biol. 2012;19:1273-81 pubmed publisher
    ..Here we show that the Polycomb repressive complex 2 (PRC2) component PHF19 binds trimethylated histone H3 Lys36 (H3K36me3), a mark of active chromatin, via its Tudor domain...
  23. Ballaré C, Lange M, Lapinaite A, Martin G, Morey L, Pascual G, et al. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012;19:1257-65 pubmed publisher
    ..recognition of methylated histone H3 Lys36 (H3K36me), a mark associated with activation, by the PRC2 subunit Phf19 is required for the full enzymatic activity of the PRC2 complex...
  24. Boulay G, Dubuissez M, Van Rechem C, Forget A, Helin K, Ayrault O, et al. Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins. J Biol Chem. 2012;287:10509-24 pubmed publisher
    ..Thus, our results identify HIC1 as the first transcription factor in mammals able to recruit PRC2 to some target promoters through its interaction with Polycomb-like proteins. ..