Gene Symbol: PHF12
Description: PHD finger protein 12
Alias: PF1, PHD finger protein 12, PHD factor 1, PHD zinc finger transcription factor
Species: human
Products:     PHF12

Top Publications

  1. Tanwar A, Patidar S, Ahirwar S, Dehingia S, Iyer P. "Receptor free" inner filter effect based universal sensors for nitroexplosive picric acid using two polyfluorene derivatives in the solution and solid states. Analyst. 2019;144:669-676 pubmed publisher fluorescent conjugated polymers (CPs) of fluorene namely 9,9-bis(6-bromohexyl)-2-phenyl-9H-fluorene (PF1) and 9,9-bis(6-bromohexyl)-9H-fluorene (PF2) were synthesized using Suzuki cross coupling polymerization and ..
  2. Coste Sanchez C, Kalra A, Li T, Jay M. Solid-State Characterization of Three Polymorphs of an Orally Available Analog of Diethylenetriaminepentaacetic Acid. AAPS PharmSciTech. 2018;20:8 pubmed publisher
    The present work investigated the physical and thermal characteristics of three polymorphic forms (namely, PF1, PF2, and PF3) of a diethyl ester analog of diethylenetriaminepentaacetic acid (C2E2) produced under varying conditions...
  3. Conti A, Humphris G. Patient centred consultation, satisfaction and young patients: A cross-country analysis. Patient Educ Couns. 2019;102:782-789 pubmed publisher
    ..Countries' mean scores on 'Satisfaction with Care' (PF1) and on 'Psychosocial Context' (PF2) were statistically significant by inspecting the ANOVAs (p < .05)...
  4. Purslow J, Nguyen T, Egner T, Dotas R, Khatiwada B, Venditti V. Active Site Breathing of Human Alkbh5 Revealed by Solution NMR and Accelerated Molecular Dynamics. Biophys J. 2018;115:1895-1905 pubmed publisher
    ..Consistent with this observation, backbone amide residual dipolar couplings measured for Alkbh5 in phage pf1 are inconsistent with the static crystal structure of the enzyme...
  5. Weinberg L, Scurrah N, Parker F, Dauer R, Marshall J, McCall P, et al. Markers of coagulation activation after hepatic resection for cancer: evidence of sustained upregulation of coagulation. Anaesth Intensive Care. 2011;39:847-53 pubmed
    ..partial thromboplastin time, we measured select markers of coagulation activation prothrombin fragments 1 and 2 (PF1 + 2), thrombin-antithrombin complexes and plasma von Willebrand Factor antigen in 21 patients undergoing hepatic ..
  6. Marek A, Tang W, Milikisiyants S, Nevzorov A, Smirnov A. Nanotube array method for studying lipid-induced conformational changes of a membrane protein by solid-state NMR. Biophys J. 2015;108:5-9 pubmed publisher
    ..solid-state nuclear magnetic resonance studies of lipid-induced conformational changes of uniformly (15)N-labeled Pf1 coat protein in native-like bilayers...
  7. Hagn F, Wagner G. Structure refinement and membrane positioning of selectively labeled OmpX in phospholipid nanodiscs. J Biomol NMR. 2015;61:249-60 pubmed publisher
    ..In addition, we were able to obtain residual dipolar couplings (RDCs) of OmpX in nanodiscs using Pf1 phage medium for the induction of weak alignment...
  8. Xie T, Zmyslowski A, Zhang Y, Radhakrishnan I. Structural Basis for Multi-specificity of MRG Domains. Structure. 2015;23:1049-57 pubmed publisher
    ..Previous studies with Pf1, another chromatin-binding subunit of the Sin3S/Rpd3S histone deacetylase complex, defined the sequence and ..
  9. Ying J, Roche J, Bax A. Homonuclear decoupling for enhancing resolution and sensitivity in NOE and RDC measurements of peptides and proteins. J Magn Reson. 2014;241:97-102 pubmed publisher
    ..The approach is demonstrated for measurement of RDCs in protonated (15)N/(13)C-enriched ubiquitin, aligned in Pf1, yielding improved fitting to the ubiquitin structure.

More Information


  1. Felip O, Blasco J, Ibarz A, Martín Pérez M, Fernández Borràs J. Diets labelled with (13)C-starch and (15)N-protein reveal daily rhythms of nutrient use in gilthead sea bream (Sparus aurata). Comp Biochem Physiol A Mol Integr Physiol. 2015;179:95-103 pubmed publisher
    ..The Cd/Cd group only received the commercial diet (control group). After 56days, two force-feeding experiments (PF1 and PF2) measured for all three groups the fate of a single meal labelled with (15)N-protein and (13)C-starch ..
  2. Biniarz P, Coutte F, Gancel F, Łukaszewicz M. High-throughput optimization of medium components and culture conditions for the efficient production of a lipopeptide pseudofactin by Pseudomonas fluorescens BD5. Microb Cell Fact. 2018;17:121 pubmed publisher
    ..Pseudofactin (PF) is a lipopeptide produced by Pseudomonas fluorescens BD5. Recently, we identified two analogues, PF1 (C16-Val) and PF2 (C16-Leu), and reported that PF2 has good emulsification and foaming ..
  3. Wnorowska U, Niemirowicz K, Myint M, Diamond S, Wróblewska M, Savage P, et al. Bactericidal activities of cathelicidin LL-37 and select cationic lipids against the hypervirulent Pseudomonas aeruginosa strain LESB58. Antimicrob Agents Chemother. 2015;59:3808-15 pubmed publisher
    ..We observed strong inhibition of LL-37 bactericidal activity in the presence of purified bacteriophage Pf1, which is highly expressed by P...
  4. Purdey M, Connaughton H, Whiting S, Schartner E, Monro T, Thompson J, et al. Boronate probes for the detection of hydrogen peroxide release from human spermatozoa. Free Radic Biol Med. 2015;81:69-76 pubmed publisher
    ..This study reports the synthesis and use of three aryl boronate probes, peroxyfluor-1 (PF1), carboxyperoxyfluor-1, and a novel probe, 2-(2-ethoxyethoxy)ethoxyperoxyfluor-1 (EEPF1), in human spermatozoa...
  5. Cai H, Agrawal A, Putt D, Hashim M, Reddy A, Brodfuehrer J, et al. Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells. Toxicology. 2009;258:56-63 pubmed
    b>PF1, an anti-inflammatory drug candidate, was nephrotoxic in cynomolgus monkeys in a manner that was qualitatively comparable to that observed with the two previous exploratory drug candidates (PF2and PF3)...
  6. McLawhorn A, Beathe J, YaDeau J, Buschiazzo V, Purdue P, Ma Y, et al. Effects of steroids on thrombogenic markers in patients undergoing unilateral total knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Res. 2015;33:412-6 pubmed publisher
    ..30 patients undergoing unilateral TKA to assess the effect of perioperative steroids on serum prothrombin fragment (PF1.2), a marker of thrombin generation, and plasmin-alpha-2-antiplasmin complex (PAP), a marker of fibrinolysis...
  7. Lapin J, Nevzorov A. Automated assignment of NMR spectra of macroscopically oriented proteins using simulated annealing. J Magn Reson. 2018;293:104-114 pubmed publisher
    ..For the 20-residue transmembrane domain of Pf1 coat protein reconstituted in magnetically aligned bicelles, the original assignment by Park et al...
  8. Gkorezis P, Rineau F, Van Hamme J, Franzetti A, Daghio M, Thijs S, et al. Draft Genome Sequence of Acinetobacter oleivorans PF1, a Diesel-Degrading and Plant-Growth-Promoting Endophytic Strain Isolated from Poplar Trees Growing on a Diesel-Contaminated Plume. Genome Announc. 2015;3: pubmed publisher
    We report the 3.7-Mb draft genome of Acinetobacter oleivorans strain PF1, a hydrocarbonoclastic Gram-negative bacterium in the class Gammaproteobacteria, isolated from poplar trees growing on a diesel-contaminated plume at the Ford Motor ..
  9. Chen F, Klein A, Klein B, Lee K, Truitt B, Klein R, et al. Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure. Invest Ophthalmol Vis Sci. 2014;56:544-51 pubmed publisher
    ..Gene-based analysis found suggestive associations between IOP and the genes HAP1, MTBP, FREM3, and PHF12. We successfully replicated the associations with GAS7 (P = 7...
  10. Fernández Moreno J, Tzfadia O, Forment J, Presa S, Rogachev I, Meir S, et al. Characterization of a New Pink-Fruited Tomato Mutant Results in the Identification of a Null Allele of the SlMYB12 Transcription Factor. Plant Physiol. 2016;171:1821-36 pubmed publisher
    ..Two new mutant lines displaying a pink fruit phenotype (pf1 and pf2) were characterized in this study...
  11. Sergeyev I, Itin B, Rogawski R, Day L, McDermott A. Efficient assignment and NMR analysis of an intact virus using sequential side-chain correlations and DNP sensitization. Proc Natl Acad Sci U S A. 2017;114:5171-5176 pubmed publisher
    ..Data collected in <1 wk produced a virtually complete de novo assignment of the coat protein of Pf1 virus. The peak positions and linewidths for samples near 100 K are perturbed relative to those near 273 K...
  12. Evgeny N, Jerschow A. Quadrupole sensitive pulse for signal filtering. J Magn Reson. 2016;265:153-63 pubmed publisher
    ..Using a combination of simulations and experiments with (23)Na in NaCl solution, Pf1-solutions, and bovine patellar cartilage samples we further show how the value of the quadrupolar frequency and ..
  13. Bansal N, Petrie K, Christova R, Chung C, Leibovitch B, Howell L, et al. Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer. Oncotarget. 2015;6:34087-105 pubmed publisher
    ..Here, we report the identification of the SID-containing adaptor PF1 as a factor required for maintenance of the TNBC stem cell phenotype and epithelial-to-mesenchymal transition (EMT)...
  14. Mengual L, Lozano J, Ingelmo Torres M, Izquierdo L, Musquera M, Ribal M, et al. Using gene expression from urine sediment to diagnose prostate cancer: development of a new multiplex mRNA urine test and validation of current biomarkers. BMC Cancer. 2016;16:76 pubmed publisher
    ..Seven of the 42 genes evaluated (PCA3, ELF3, HIST1H2BG, MYO6, GALNT3, PHF12 and GDF15) were found to be independent predictors for discriminating patients with PCa from controls...
  15. Pillay S, Li Y, Wong L, Pervushin K. Structural characterization of eRF1 mutants indicate a complex mechanism of stop codon recognition. Sci Rep. 2016;6:18644 pubmed publisher
    ..N-domain weakly aligned in either 5% w/v n-octyl-penta (ethylene glycol)/octanol (C8E5) or the filamentous phage Pf1. These data indicate that the mutations alter the conformation and dynamics of the GTS loop that is distant from ..
  16. Angin S, Mickle K, Nester C. Contributions of foot muscles and plantar fascia morphology to foot posture. Gait Posture. 2018;61:238-242 pubmed publisher
    ..flexor hallucis brevis (FHB), flexor digitorum brevis (FDB) and abductor hallucis (AbH) muscles, and the calcaneal (PF1), middle (PF2) and metatarsal (PF3) regions of the plantar fascia were obtained using a Venue 40 ultrasound system ..
  17. Knezevic P, Voet M, Lavigne R. Prevalence of Pf1-like (pro)phage genetic elements among Pseudomonas aeruginosa isolates. Virology. 2015;483:64-71 pubmed publisher
    b>Pf1-like bacteriophages (family Inoviridae) of Pseudomonas aeruginosa can contribute to bacterial short term evolution and virulence. Here we examine Pf1-like (pro)phage diversity and prevalence among different P. aeruginosa isolates...
  18. Zamboni P, Sisini F, Menegatti E, Taibi A, Gadda G, Tavoni V, et al. Ultrasound Monitoring of Jugular Venous Pulse during Space Missions: Proof of Concept. Ultrasound Med Biol. 2018;44:726-733 pubmed publisher six experimental sessions; two pre-flight (BDC1 and -2), two in space (ISS1 and -2) and two post-flight (Houston PF1, Cologne PF2)...
  19. Paparella D, Parolari A, Rotunno C, Vincent J, Myasoedova V, Guida P, et al. The Effects of Steroids on Coagulation Dysfunction Induced by Cardiopulmonary Bypass: A Steroids in Cardiac Surgery (SIRS) Trial Substudy. Semin Thorac Cardiovasc Surg. 2017;29:35-44 pubmed publisher
    ..A substudy was conducted in 2 sites to collect blood samples perioperatively to measure prothrombin fragment 1.2 (PF1+2, thrombin generation), plasmin-antiplasmin complex (PAP, fibrinolysis), platelet factor 4 (PF4 platelet ..
  20. Santos M, Assao V, Santos F, Salgado R, Carneiro A, Fietto J, et al. Utilization of phage display to identify antigenic regions in the PCV2 capsid protein for the evaluation of serological responses in mice and pigs. Arch Virol. 2018;163:1877-1887 pubmed publisher
    ..mice: 51-CTFGYTIKRTVT-62 (PS14), 127-CDNFVTKATALTY-138 (PS34), 164-CKPVLDSTIDY-173 (PC12), and 79-CFLPPGGGSNT-88 (PF1). Inoculation with the PC12 peptide led to the highest production of antibodies...
  21. Awosanya E, Nevzorov A. Protein Rotational Dynamics in Aligned Lipid Membranes Probed by Anisotropic T1ρ NMR Relaxation. Biophys J. 2018;114:392-399 pubmed publisher
    A membrane-bound form of Pf1 coat protein reconstituted in magnetically aligned DMPC/DHPC bicelles was used as a molecular probe to quantify for the viscosity of the lipid membrane interior by measuring the uniaxial rotational diffusion ..
  22. Yusuf J, Goyal M, Mukhopadhyay S, Mehta V, Dhaiya S, Saxena R, et al. Effect of heart rate control on coagulation status in patients of rheumatic mitral stenosis with atrial fibrillation--A pilot study. Indian Heart J. 2015;67 Suppl 2:S40-5 pubmed publisher
    ..30 healthy volunteers acted as controls. Plasma concentration of prothrombin fragment 1+2 (PF1+2) 6600 pmol/ml [interquartile range (IQR) 5400.0-9500], thrombin antithrombin III 22.0 ng/ml [IQR 18.6-28...
  23. El Gendy M, Al Zahrani H, Abozinadah N, El Bondkly A. In Vivo Evaluation of the Toxic Effect of Ethyl Acetate Extracts of Marine Antibiotic Resistance Pseudomonas Species Derived from the Red Sea. Appl Biochem Biotechnol. 2018;184:323-349 pubmed publisher
    ..Genotypic (exoT, exoS, exoU, exoY, lasA, lasB, rhlA, rhlB, Pf1, PAGI-1, -2, and -3) and phenotypic (DNase, elastase, lipase, protease, siderophore, antibiotic resistance patterns)..
  24. Graveline R, Marcinkiewicz K, Choi S, Paquet M, Wurst W, Floss T, et al. The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence. Mol Cell Biol. 2017;37: pubmed publisher
    Pf1, also known as Phf12 (plant homeodomain [PHD] zinc finger protein 12), is a member of the PHD zinc finger family of proteins...
  25. Altan S, Berberoglu B, Canan S, Dane S. Effects of neurofeedback therapy in healthy young subjects. Clin Invest Med. 2016;39:27496 pubmed
    ..made with bipolar electrodes placed on T3 and T4 (temporal 3 and 4) regions and with reference electrode placed on PF1 (prefrontal 1)...
  26. Zhang Y, Nie P, Lin L. Complete Genome Sequence of the Fish Pathogen Flavobacterium columnare Pf1. Genome Announc. 2016;4: pubmed publisher
    ..Here, we describe the complete genome of F. columnare strain Pf1, a highly virulent strain isolated from yellow catfish (Pelteobagrus fulvidraco) in China.
  27. Koroloff S, Nevzorov A. Optimization of cross-polarization at low radiofrequency fields for sensitivity enhancement in solid-state NMR of membrane proteins reconstituted in magnetically aligned bicelles. J Magn Reson. 2015;256:14-22 pubmed publisher
    ..By contrast, in purely static (NAL crystal) and semi-rigid systems (Pf1 phage), the adiabatic CP was found to be more effective...
  28. Bucki R, Niemirowicz K, Wnorowska U, WÄ…tek M, Byfield F, Cruz K, et al. Polyelectrolyte-mediated increase of biofilm mass formation. BMC Microbiol. 2015;15:117 pubmed publisher
    ..the impact of diverse natural polyelectrolytes, such as DNA, F-actin, neurofilaments (NFs), vimentin and purified Pf1 bacteriophage on biofilm formation and swarming motility of select pathogens including Pseudomonas aeruginosa ..
  29. Zhang Y, Zhao L, Chen W, Huang Y, Yang L, Sarathbabu V, et al. Complete genome sequence analysis of the fish pathogen Flavobacterium columnare provides insights into antibiotic resistance and pathogenicity related genes. Microb Pathog. 2017;111:203-211 pubmed publisher
    We analyzed here the complete genome sequences of a highly virulent Flavobacterium columnare Pf1 strain isolated in our laboratory. The complete genome consists of a 3,171,081 bp circular DNA with 2784 predicted protein-coding genes...
  30. Koroloff S, Tesch D, Awosanya E, Nevzorov A. Sensitivity enhancement for membrane proteins reconstituted in parallel and perpendicular oriented bicelles obtained by using repetitive cross-polarization and membrane-incorporated free radicals. J Biomol NMR. 2017;67:135-144 pubmed publisher
    ..4-3.0 in the case of Pf1 coat protein reconstituted in magnetically aligned bicelles with their normals being either parallel or ..
  31. Modi M, Majchrzak M, Fonseca K, Doran A, Osgood S, Vanase Frawley M, et al. Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing. J Pharmacol Exp Ther. 2016;358:164-72 pubmed publisher
    ..To explore the behavioral efficacy of an OT analog with enhanced plasma stability, we developed PF-06655075 (PF1), a novel non-brain-penetrant OT receptor agonist with increased selectivity for the OT receptor and significantly ..
  32. Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, et al. MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks. J Cell Sci. 2010;123:1124-30 pubmed publisher
    ..These results suggest that MRG15 mediates DNA-damage-response functions of the BRCA complex in chromatin. ..
  33. Yu M, He S, Tang M, Zhang Z, Zhu Y, Sun H. Antioxidant activity and sensory characteristics of Maillard reaction products derived from different peptide fractions of soybean meal hydrolysate. Food Chem. 2018;243:249-257 pubmed publisher
    Four peptide fractions PF1 (>5;kDa), PF2 (3-5;kDa), PF3 (1-3;kDa), PF4 (<1;kDa) were isolated from soybean hydrolysate using the ultrafiltration method...
  34. Yochum G, Ayer D. Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. Mol Cell Biol. 2001;21:4110-8 pubmed
    ..We identified a novel mSin3A-interacting protein that has two plant homeodomain (PHD) zinc fingers we term Pf1, for PHD factor one...
  35. Sy S, Huen M, Chen J. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem. 2009;284:21127-31 pubmed publisher
    ..Together, our study indicated that although PALB2 is required for proficient homologous recombination, it could also govern the choice of templates used in homologous recombination repair. ..
  36. Park S, Gupta D, Hurwich R, Kim C, Dziarski R. Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses. J Immunol. 2011;187:5813-23 pubmed publisher
    ..Thus, in wild type mice, Pglyrp2 limits overactivation of Th17 cells by promoting accumulation of regulatory T cells at the site of inflammation, which protects the skin from the exaggerated inflammatory response. ..
  37. Nazik H, Joubert L, Secor P, Sweere J, Bollyky P, Sass G, et al. Pseudomonas phage inhibition of Candida albicans. Microbiology. 2017;163:1568-1577 pubmed publisher
    ..To understand the range of this viral-fungal interaction, we studied Pa phages Pf4 and Pf1, and their interactions with Ca biofilm formation and preformed Ca biofilm...
  38. Dang P, Yu X, LE H, Liu J, Shen Z, Zhao Z. Effects of stand age and soil properties on soil bacterial and fungal community composition in Chinese pine plantations on the Loess Plateau. PLoS ONE. 2017;12:e0186501 pubmed publisher
    ..fungal community composition and diversity in soils from three stands of different-aged, designated 12-year-old (PF1), 29-year-old (PF2), and 53-year-old (PF3), on a Chinese pine plantation and from a natural secondary forest (NSF) ..
  39. Kumar G, Xie T, Zhang Y, Radhakrishnan I. Solution structure of the mSin3A PAH2-Pf1 SID1 complex: a Mad1/Mxd1-like interaction disrupted by MRG15 in the Rpd3S/Sin3S complex. J Mol Biol. 2011;408:987-1000 pubmed publisher a molecular adaptor linking histone deacetylases on the one hand, with the chromatin targeting subunits Pf1 and MRG15 on the other...
  40. Xie T, Graveline R, Kumar G, Zhang Y, Krishnan A, David G, et al. Structural basis for molecular interactions involving MRG domains: implications in chromatin biology. Structure. 2012;20:151-60 pubmed publisher
    ..Here, we structurally and functionally characterize the interaction between MRG15 and Pf1, two constitutively associated subunits of the histone deacetylase-associated Rpd3S/Sin3S corepressor complex...
  41. Yochum G, Ayer D. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. Mol Cell Biol. 2002;22:7868-76 pubmed
    ..b>Pf1 is a plant homeodomain zinc finger protein that interacts with both mSin3A and TLE, suggesting that it coordinates ..
  42. Burchall G, Piva T, Ranasinha S, Teede H. Differential Effects on Haemostatic Markers by Metformin and the Contraceptive Pill: A Randomized Comparative Trial in PCOS. Thromb Haemost. 2017;117:2053-2062 pubmed publisher plasminogen activator inhibitor 1 (PAI-1), asymmetric dimethylarginine (ADMA), prothrombin fragments 1 and 2 (PF1 and 2), plasminogen, tissue plasminogen activator (tPA), thrombin activatable fibrinolysis inhibitor (TAFI) and ..
  43. Kaadige M, Ayer D. The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. J Biol Chem. 2006;281:28831-6 pubmed
    ..We have recently identified a novel PHD-containing protein, Pf1, as a binding partner for the abundant and ubiquitous transcriptional corepressor mSin3A...