PHF1

Summary

Gene Symbol: PHF1
Description: PHD finger protein 1
Alias: MTF2L2, PCL1, PHF2, TDRD19C, hPHF1, PHD finger protein 1, hPCl1, polycomb-like 1, polycomb-like protein 1, testicular tissue protein Li 140, tudor domain containing 19C
Species: human
Products:     PHF1

Top Publications

  1. O Connell S, Wang L, Robert S, Jones C, Saint R, Jones R. Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein. J Biol Chem. 2001;276:43065-73 pubmed
    ..An association was also observed between PHF1 and EZH2, human homologs of PCL and E(Z), respectively, demonstrating the evolutionary conservation of this ..
  2. Coulson M, Robert S, Eyre H, Saint R. The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster. Genomics. 1998;48:381-3 pubmed
    ..We report here the isolation and characterization of a human cDNA, termed PHF1, which encodes a protein with significant sequence similarity to Drosophila Polycomblike (PCL)...
  3. Sarma K, Margueron R, Ivanov A, Pirrotta V, Reinberg D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol. 2008;28:2718-31 pubmed publisher
    The mammalian Polycomblike protein PHF1 was previously shown to interact with the Polycomb group (PcG) protein Ezh2, a histone methyltransferase whose activity is pivotal in sustaining gene repression during development and in adulthood...
  4. Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, et al. A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell. Nucleic Acids Res. 2008;36:2939-47 pubmed publisher
    ..By screening proteins responding to DNA damage using laser micro-irradiation, we found that PHF1, a human homolog of Drosophila polycomb-like, Pcl, protein, was recruited to DSBs immediately after irradiation and ..
  5. Cao R, Wang H, He J, Erdjument Bromage H, Tempst P, Zhang Y. Role of hPHF1 in H3K27 methylation and Hox gene silencing. Mol Cell Biol. 2008;28:1862-72 pubmed
    ..EED-EZH2 protein complex which is distinguished from the previous complex by the presence of another PcG protein, hPHF1. Consistent with the ability of hPHF1 to stimulate the enzymatic activity of the core EED-EZH2 complex in vitro, ..
  6. McCarthy A, Clarke B, McGilvray I, Dickson B, Khalili K, Chetty R. Metastatic low-grade endometrial stromal sarcoma of uterus presenting as a primary pancreatic tumor: case presentation and literature review. Diagn Pathol. 2019;14:30 pubmed publisher
    ..RNA sequencing detected a PHF1 rearrangement...
  7. Sekhar S, Panda D, Kumar J, Mohanty N, Biswal M, Baig M, et al. Comparative transcriptome profiling of low light tolerant and sensitive rice varieties induced by low light stress at active tillering stage. Sci Rep. 2019;9:5753 pubmed publisher
    ..CAB, LRP, SBPase, MT15, TF PCL1 and Photosystem I & II complex related gene expressions were mostly increased in Swarnaprabha upon longer ..
  8. Ghosh A, Maiti G, Bandopadhyay M, Chakraborty J, Biswas J, Roychoudhury S, et al. Inactivation of 9q22.3 tumor suppressor genes predict outcome for patients with head and neck squamous cell carcinoma. Anticancer Res. 2013;33:1215-20 pubmed
    This study examined the prognostic significance of candidate tumor suppressor genes (TSGs) PHD finger protein-2 (PHF2), Fanconi anaemia complementation group C (FANCC) and human homologue of Drosophila patched gene (PTCH1), in head and ..
  9. Arnau Soler A, MacDonald Dunlop E, Adams M, Clarke T, MacIntyre D, Milburn K, et al. Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Transl Psychiatry. 2019;9:14 pubmed publisher
    ..GWEIS gene-based tests identified: MTNR1B with GxE effect with dependent SLE in Generation Scotland; and PHF2 with the joint effect in UK Biobank (p < 2.77 × 10-6)...

More Information

Publications86

  1. Kant S, Peng M, Rothstein S. Genetic regulation by NLA and microRNA827 for maintaining nitrate-dependent phosphate homeostasis in arabidopsis. PLoS Genet. 2011;7:e1002021 pubmed publisher
    ..Map-based cloning identified these suppressors as the phosphate (Pi) transport-related genes PHF1 and PHT1.1. In addition, NLA expression is shown to be regulated by the low-Pi induced microRNA miR827...
  2. Ge Z, Han Q, Gu Y, Ge Q, Ma J, Sloane J, et al. Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia. Oncogenesis. 2018;7:84 pubmed publisher
    ..ARID5B also interacts with PHD finger protein 2 (PHF2)...
  3. Fellous A, Earley R, Silvestre F. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 2019;687:173-187 pubmed publisher
    ..Kdm1a, Kdm1b, Kdm2a, Kdm2b, Kdm3b, Kdm4a, Kdm4b, Kdm4c, Kdm5a, Kdm5b, Kdm5c, Kdm6a, Kdm6b, Kdm7a, Kdm8, Kdm9, UTY, Phf2 and Phf8) and forty-eight Kmt orthologues (Ezh1, Ezh2, Setd2, Nsd1, Nsd2, Nsd3, Ash1l, Kmt2e, Setd5, Prdm1, Prdm2, ..
  4. Sapienza M, Abate F, Melle F, Orecchioni S, Fuligni F, Etebari M, et al. Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target. Haematologica. 2019;104:729-737 pubmed publisher
    ..0001). In particular, twenty-five epigenetic modifiers were found mutated (e.g. ASXL1, TET2, SUZ12, ARID1A, PHF2, CHD8); ASXL1 was the most frequently affected (28.6% of cases)...
  5. Ali R, Al Safi R, Al Waheeb S, John B, Al Ali W, Al Jassar W, et al. Molecular characterization of a population-based series of endometrial stromal sarcomas in Kuwait. Hum Pathol. 2014;45:2453-62 pubmed publisher
    ..Thirteen (81.3%) of 16 LGESSs with interpretable results showed JAZF1 and/or PHF1 genetic rearrangements by fluorescence in situ hybridization, and the only HGESS in the series showed YWHAE genetic ..
  6. Koss D, Dubini M, Buchanan H, Hull C, Platt B. Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer's disease. Brain Res. 2018;1699:121-134 pubmed publisher
    ..05 high cf. low severity). In contrast, PHF1 phospho-tau, TOC1 reactive tau oligomers and amyloid markers rose within the two fractions simultaneously...
  7. Ruan W, Guo M, Cai L, Hu H, Li C, Liu Y, et al. Genetic manipulation of a high-affinity PHR1 target cis-element to improve phosphorous uptake in Oryza sativa L. Plant Mol Biol. 2015;87:429-40 pubmed publisher
    ..Using the cis-regulator HA-P1BS, we modified the promoters of Transporter Traffic Facilitator 1 (PHF1), a key factor controlling endoplasmic reticulum-exit of phosphate transporters to the plasma membrane, for ..
  8. Zou J, Friesen H, Larson J, Huang D, Cox M, Tatchell K, et al. Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae. Mol Biol Cell. 2009;20:3239-50 pubmed publisher
    In the budding yeast Saccharomyces cerevisiae, the G1-specific cyclin-dependent kinases (Cdks) Cln1,2-Cdc28 and Pcl1,2-Pho85 are essential for ensuring that DNA replication and cell division are properly linked to cell polarity and bud ..
  9. Shi G, Wu M, Fang L, Yu F, Cheng S, Li J, et al. PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1. J Biol Chem. 2014;289:29691-700 pubmed publisher
    Regulation of rDNA transcription is central to cell growth and proliferation. PHF2 and PHF8 belong to a subfamily of histone demethylases that also possess a PHD domain-dependent di-/trimethylated histone 3 lysine 4 (H3K4me2/3) binding ..
  10. Rege S, Geetha T, Broderick T, Babu J. Resveratrol protects β amyloid-induced oxidative damage and memory associated proteins in H19-7 hippocampal neuronal cells. Curr Alzheimer Res. 2015;12:147-56 pubmed
    ..Aβ treatment also increased the expression of total tau as well as phosphorylated forms of tau (CP13, S202/205; PHF1, S396/404) and decreased the expression of insulin degrading enzyme (IDE), phosphoglycogen synthase kinase 3β ..
  11. Tajima S, Koda K. Atypical ossifying fibromyxoid tumor unusually located in the mediastinum: report of a case showing mosaic loss of INI-1 expression. Int J Clin Exp Pathol. 2015;8:2139-45 pubmed
    ..Inactivation of INI-1 gene and deregulation of PHF1 gene are thought to be involved in tumorigenesis of OFMT...
  12. Bricambert J, Alves Guerra M, Esteves P, Prip Buus C, Bertrand Michel J, Guillou H, et al. The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun. 2018;9:2092 pubmed publisher
    ..Here, we identify the histone demethylase Plant Homeodomain Finger 2 (Phf2) as a new transcriptional co-activator of the transcription factor Carbohydrate Responsive Element Binding Protein (..
  13. Joshi V, Subbanna S, Shivakumar M, Basavarajappa B. CB1R regulates CDK5 signaling and epigenetically controls Rac1 expression contributing to neurobehavioral abnormalities in mice postnatally exposed to ethanol. Neuropsychopharmacology. 2019;44:514-525 pubmed publisher
    ..activity before ethanol exposure prevented accumulation of cleaved caspase-3 (CC3) and hyperphosphorylated tau (PHF1) (a marker for neurodegeneration) in neonatal mice and reversed cAMP response element-binding protein (CREB) ..
  14. Xia D, Li C, Götz J. Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines. Biochim Biophys Acta. 2015;1852:913-24 pubmed publisher
    ..When distinct phosphorylation sites (AT180-T231/S235, 12E8-S262/S356, PHF1-S396/S404) were pseudophosphorylated (with glutamic acid, using alanine replacements as controls), Tau targeting to ..
  15. Yan D, Yao J, Liu Y, Zhang X, Wang Y, Chen X, et al. Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin. Brain Behav Immun. 2018;71:66-80 pubmed publisher
    ..of hyperphosphorylated tau including p-tau (Ser262), AT8 (p-tau Ser202/Thr205) and PHF1 (p-tau Ser396/404) in the hippocampus and cortex...
  16. Hochgräfe K, Sydow A, Matenia D, Cadinu D, Könen S, Petrova O, et al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015;3:25 pubmed publisher
    ..decrease of insoluble Tau, a reduction of conformationally changed (MC1) and phosphorylated Tau species (AT180, PHF1) as well as an upregulation of protein degradation systems (autophagy and proteasome)...
  17. Liu R, Gao J, Yang Y, Qiu R, Zheng Y, Huang W, et al. PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis. Nucleic Acids Res. 2018;46:6608-6626 pubmed publisher
    ..b>PHF1 [plant homeodomain (PHD) finger protein 1], which contains two kinds of histone reader modules, a Tudor domain and ..
  18. Driscoll I, Troncoso J, Rudow G, Sojkova J, Pletnikova O, Zhou Y, et al. Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques. Acta Neuropathol. 2012;124:823-31 pubmed publisher
    ..2-2.4 years). The total number of Aβ plaques (6E10) and NFTs (PHF1) in paraffin sections from hippocampus, orbito-frontal cortex, anterior and posterior cingulate gyrus, precuneus ..
  19. Kim H, Park J, Lee K, Yoon H, Shin D, Ju U, et al. Plant homeodomain finger protein 2 promotes bone formation by demethylating and activating Runx2 for osteoblast differentiation. Cell Res. 2014;24:1231-49 pubmed publisher
    Plant homeodomain finger protein 2 (PHF2), which contains a plant homeodomain and a Jumonji-C domain, is an epigenetic regulator that demethylates lysine 9 in histone 3 (H3K9me2)...
  20. Cao L, Liang Y, Liu Y, Xu Y, Wan W, Zhu C. Pseudo-phosphorylation at AT8 epitopes regulates the tau truncation at aspartate 421. Exp Cell Res. 2018;370:103-115 pubmed publisher
    ..at S422 and the epitope of the diagnostic antibody AT8 (S199?+?S202?+?T205), but a moderate dephosphorylation of PHF1 (S396?+?S404) epitope...
  21. Lee K, Ju U, Song J, Chun Y. The histone demethylase PHF2 promotes fat cell differentiation as an epigenetic activator of both C/EBPα and C/EBPδ. Mol Cells. 2014;37:734-41 pubmed publisher
    ..Plant homeodomain finger 2 (PHF2) is a Jumonji domain-containing protein and is known to demethylate the histone H3K9, a repressive gene marker...
  22. Khan S, Yuldasheva N, Batten T, Pickles A, Kellett K, Saha S. Tau pathology and neurochemical changes associated with memory dysfunction in an optimised murine model of global cerebral ischaemia - A potential model for vascular dementia?. Neurochem Int. 2018;118:134-144 pubmed publisher
    ..for glial (GLT1) and vesicular (VGLUT1, VGLUT2) glutamate transporters and paired helical filament (PHF1) tau...
  23. Li X, Anand M, Haimes J, Manoj N, Berlin A, Kudlow B, et al. The application of next-generation sequencing-based molecular diagnostics in endometrial stromal sarcoma. Histopathology. 2016;69:551-9 pubmed publisher
    ..additional diagnostic insights, as low-grade ESSs frequently harbour fusions involving JAZF1/SUZ12 and/or JAZF1/PHF1, whereas high-grade ESSs are defined by YWHAE-NUTM2A/B fusions...
  24. Phanopoulos A, White A, Long N, Miller P. Insight into the stereoelectronic parameters of N-triphos ligands via coordination to tungsten(0). Dalton Trans. 2016;45:5536-48 pubmed publisher
    ..The steric and electronic parameters of five N-triphos ligands: NP3(Ph), NP3(iPr), NP3(Cyp), NP3(Cyh) and NP3(PhF2), and the carbon-centred triphos ligand, CH3C(CH2PPh2)3 (MeCP3(Ph)), were established...
  25. Degani G, Ragni E, Botías P, Ravasio D, Calderon J, Pianezzola E, et al. Genomic and functional analyses unveil the response to hyphal wall stress in Candida albicans cells lacking ?(1,3)-glucan remodeling. BMC Genomics. 2016;17:482 pubmed publisher
    ..of DNA replication genes associated with entry into S-phase occurred whereas cell-cycle regulating genes (PCL1, PCL2, CCN1, GIN4, DUN1, CDC28) were persistently up-regulated...
  26. Hoang L, Chiang S, Lee C. Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations. Pathology. 2018;50:162-177 pubmed publisher
    ..Less common JAZF1-PHF1, EPC1-PHF1, MEAF6-PHF1, and MBTD1-CXorf67 fusions have also been reported...
  27. Salkovic Petrisic M, Knezovic A, Osmanovic Barilar J, Smailovic U, Trkulja V, Riederer P, et al. Multi-target iron-chelators improve memory loss in a rat model of sporadic Alzheimer's disease. Life Sci. 2015;136:108-19 pubmed publisher
    ..05) and fully restored them in PA test (+314%; p b 0.05). Chronic M30 treatment fully restored (−47%/PHF1;−65%/AT8; p b 0...
  28. Schoolmeester J, Sciallis A, Greipp P, Hodge J, Dal Cin P, Keeney G, et al. Analysis of MDM2 Amplification in 43 Endometrial Stromal Tumors: A Potential Diagnostic Pitfall. Int J Gynecol Pathol. 2015;34:576-83 pubmed publisher
    ..In addition, 40 of the 43 cases had previously undergone fluorescence in situ hybridization analysis of JAZF1, PHF1, and YHWAE...
  29. Oliviero G, Brien G, Waston A, Streubel G, Jerman E, Andrews D, et al. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. Mol Cell Proteomics. 2016;15:3450-3460 pubmed
    ..For example, SALL4 and ZNF281 associate with PRC2 in pluripotent cells, whereas PCL1 and SMAD3 preferentially associate with PRC2 in differentiating cells...
  30. Chen S, Wang C, Xiang H. Sequence analysis and minimal replicon determination of a new haloarchaeal plasmid pHF2 isolated from Haloferax sp. strain Q22. Plasmid. 2016;83:1-7 pubmed publisher
    A new cryptic plasmid, pHF2 (2520 bp), was isolated from Haloferax sp. strain Q22 (CGMCC 1.15317), a haloarchaeal strain living in a subterranean halite deposit...
  31. Park S, Park J, Chun Y. Jumonji histone demethylases as emerging therapeutic targets. Pharmacol Res. 2016;105:146-51 pubmed publisher
    ..Recently, KDM7C (alternatively named PHF2) was discovered as a new KDM7 member and identified to play a tumor-suppressive role through the reinforcement of ..
  32. Dantey K, Schoedel K, Yergiyev O, McGough R, Palekar A, Rao U. Ossifying fibromyxoid tumor: a study of 6 cases of atypical and malignant variants. Hum Pathol. 2017;60:174-179 pubmed publisher
    ..Fluorescence in situ hybridization (FISH) detected rearrangement of the PHF1 gene in 5 cases. All cases were positive for EAAT4 and actin by immunohistochemistry, while negative for desmin...
  33. Micci F, Gorunova L, Agostini A, Johannessen L, Brunetti M, Davidson B, et al. Cytogenetic and molecular profile of endometrial stromal sarcoma. Genes Chromosomes Cancer. 2016;55:834-46 pubmed publisher
    ..FISH analysis identified a known EPC1-PHF1 fusion which led to the identification of a new variant at the molecular level...
  34. Lee J, Yoo N, Kim M, Lee S. Histone Demethylase Gene PHF2 Is Mutated in Gastric and Colorectal Cancers. Pathol Oncol Res. 2017;23:471-476 pubmed publisher
    Alterations of genes involved in histone modification are common in cancers. A histone demethylase-encoding gene PHF2 is considered a putative tumor suppressor gene (TSG)...
  35. Hochfeld L, Anhalt T, Reinbold C, Herrera Rivero M, Fricker N, Nothen M, et al. Expression profiling and bioinformatic analyses suggest new target genes and pathways for human hair follicle related microRNAs. BMC Dermatol. 2017;17:3 pubmed publisher
    ..g., ITGB1, SOX9), the majority have not been previously implicated (e.g., PHF1)...
  36. Kátai E, Pal J, Poór V, Purewal R, Miseta A, Nagy T. Oxidative stress induces transient O-GlcNAc elevation and tau dephosphorylation in SH-SY5Y cells. J Cell Mol Med. 2016;20:2269-2277 pubmed publisher
    ..Interestingly, we also found that tau protein phosphorylation at site S262 showed parallel, whereas at S199 and PHF1 sites showed inverse dynamic to O-Glycosylation...
  37. Reilly P, Winston C, Baron K, Trejo M, Rockenstein E, Akers J, et al. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiol Dis. 2017;106:222-234 pubmed publisher
    ..appearance on transmission electron microscopy (TEM) with immunogold, which revealed paired helical filament 1 (PHF1)-positive NFTs, representing possible recruitment of endogenous tau in the aggregates...
  38. Schneider N, Fisher C, Thway K. Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis. Ann Diagn Pathol. 2016;20:52-8 pubmed publisher
    ..translocation-associated tumors, with up to 85% associated with recurrent gene rearrangements, mostly involving the PHF1 gene (including in typical, atypical, and malignant neoplasms), with EP400-PHF1 in approximately 40% of tumors, and ..
  39. Liu W, Zhao L, Blackman B, Parmar M, Wong M, Woo T, et al. Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice. J Neurosci. 2016;36:12425-12435 pubmed
    ..that direct intrahippocampal administration of the adeno-associated virus (AAV)-vectored anti-phospho-tau antibody PHF1 to P301S tau transgenic mice results in high and durable antibody expression, primarily in neurons...
  40. Zhu Y, Zhang Q, Zhang W, Li N, Dai Y, Tu J, et al. Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia. Sci Rep. 2017;7:42660 pubmed publisher
    ..Furthermore, E2-treatment also reduced BCCAO induction of dementia-related proteins expression such as p-tau (PHF1), total ubiquitin, and Aβ1-42, when examined at 6 m after BCCAO...
  41. Yang J, Ma J, Xiong Y, Wang Y, Jin K, Xia W, et al. Epigenetic regulation of megakaryocytic and erythroid differentiation by PHF2 histone demethylase. J Cell Physiol. 2018;233:6841-6852 pubmed publisher
    Plant homeodomain finger 2 (PHF2) is a JmjC family histone demethylase that demethylates H3K9me2, a repressive gene marker...
  42. Kao Y, Sung Y, Zhang L, Chen C, Huang S, Antonescu C. Expanding the molecular signature of ossifying fibromyxoid tumors with two novel gene fusions: CREBBP-BCORL1 and KDM2A-WWTR1. Genes Chromosomes Cancer. 2017;56:42-50 pubmed publisher
    ..Recurrent gene fusions involving either PHF1 or BCOR have been found in 85% of OFMT, including typical and malignant examples...
  43. Hodge J, Bedroske P, Pearce K, Sukov W. Molecular Cytogenetic Analysis of JAZF1, PHF1, and YWHAE in Endometrial Stromal Tumors: Discovery of Genetic Complexity by Fluorescence in Situ Hybridization. J Mol Diagn. 2016;18:516-26 pubmed publisher
    ..To enhance EST diagnosis, a break-apart strategy fluorescence in situ hybridization panel to detect JAZF1, PHF1, and YWHAE rearrangements was applied to a cohort of primary or metastatic endometrial stromal nodules, ESSs, or ..
  44. Agadjanyan M, Zagorski K, Petrushina I, Davtyan H, Kazarian K, Antonenko M, et al. Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency. Mol Neurodegener. 2017;12:33 pubmed publisher
    ..lysate of P301S Tg mice; (iv) inhibited cytotoxic effect of tau oligomers; (v) reduced total tau (HT7) and AT100, PHF1, AT8, AT180, p212, p214-positive tau species in brains of tau transgenic mice after intracranial injection...
  45. Wang H, Wang R, Carrera I, Xu S, Lakshmana M. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. Eneuro. 2016;3: pubmed publisher
    ..These data suggest that the overexpression of TFEB can reliably enhance autophagy in vivo, reduce levels of PHF-tau, and thereby reverse the deposition of lipofuscin granules and memory deficits. ..
  46. Przybyl J, Kidzinski L, Hastie T, Debiec Rychter M, Nusse R, van de Rijn M. Gene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway. Gynecol Oncol. 2018;149:388-393 pubmed publisher
    ..that affect proteins associated with chromatin remodeling Polycomb Repressive Complex 2 (PRC2), including SUZ12, PHF1 and EPC1...
  47. Nishiura A, Kitagawa S, Matsumura M, Kazama Y, Abe T, Mizuno N, et al. An early-flowering einkorn wheat mutant with deletions of PHYTOCLOCK 1/LUX ARRHYTHMO and VERNALIZATION 2 exhibits a high level of VERNALIZATION 1 expression induced by vernalization. J Plant Physiol. 2018;222:28-38 pubmed publisher
    ..downstream genes and photoperiod pathway genes, and found that the clock component gene PHYTOCLOCK 1/LUX ARRHYTHMO (PCL1/LUX) was not expressed in exe3 mutant plants...
  48. Pattabiraman D, Bierie B, Kober K, Thiru P, Krall J, Zill C, et al. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science. 2016;351:aad3680 pubmed publisher
    ..PKA activation triggers epigenetic reprogramming of TICs by the histone demethylase PHF2, which promotes their differentiation and loss of tumor-initiating ability...
  49. Yuan C, Huang W, Lee C, Lin M, Lee C, Kao Y, et al. Comprehensive screening for MED12 mutations in gynaecological mesenchymal tumours identified morphologically distinctive mixed epithelial and stromal tumours. Histopathology. 2017;70:954-965 pubmed publisher
    ..CD10, myogenic markers, hormone receptors, MDM2, and CDK4, and fluorescence in-situ hybridization (FISH) for JAZF1, PHF1 and YWHAE rearrangement, were performed on selected cases...
  50. Yang Y, Wang C, Zhang P, Gao K, Wang D, Yu H, et al. Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis. J Biol Chem. 2013;288:529-39 pubmed publisher
    Polycomb group protein PHF1 is well known as a component of a novel EED-EZH2·Polycomb repressive complex 2 complex and plays important roles in H3K27 methylation and Hox gene silencing...
  51. Brien G, Healy E, Jerman E, Conway E, Fadda E, O Donovan D, et al. A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence. Genes Dev. 2015;29:2231-43 pubmed publisher
    Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin...
  52. Antonescu C, Sung Y, Chen C, Zhang L, Chen H, Singer S, et al. Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors--molecular characterization shows genetic overlap with endometrial stromal sarcoma. Genes Chromosomes Cancer. 2014;53:183-93 pubmed publisher
    b>PHF1 gene rearrangements have been recently described in around 50% of ossifying fibromyxoid tumors (OFMT) including benign and malignant cases, with a small subset showing EP400-PHF1 fusions...
  53. Boulay G, Dubuissez M, Van Rechem C, Forget A, Helin K, Ayrault O, et al. Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins. J Biol Chem. 2012;287:10509-24 pubmed publisher
    ..Using multiple biochemical strategies, we demonstrated that HIC1 interacts with hPCL3 and its paralog PHF1 to form a stable complex with the PRC2 members EZH2, EED, and Suz12...
  54. D Angelo E, Ali R, Espinosa I, Lee C, Huntsman D, Gilks B, et al. Endometrial stromal sarcomas with sex cord differentiation are associated with PHF1 rearrangement. Am J Surg Pathol. 2013;37:514-21 pubmed publisher
    ..was prepared, and FISH analysis was performed using break-apart and fusion probes for JAZF1, SUZ12, EPC1, and PHF1 genes...
  55. Cai L, Rothbart S, Lu R, Xu B, Chen W, Tripathy A, et al. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell. 2013;49:571-82 pubmed publisher
    ..H3K36me3) binding activity is harbored in the Tudor motifs of PRC2-associated polycomb-like (PCL) proteins PHF1/PCL1 and PHF19/PCL3...
  56. Ballaré C, Lange M, Lapinaite A, Martin G, Morey L, Pascual G, et al. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012;19:1257-65 pubmed publisher
    ..These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells. ..
  57. Graham R, Weiss S, Sukov W, Goldblum J, Billings S, Dotlic S, et al. PHF1 rearrangements in ossifying fibromyxoid tumors of soft parts: A fluorescence in situ hybridization study of 41 cases with emphasis on the malignant variant. Am J Surg Pathol. 2013;37:1751-5 pubmed publisher
    ..Very recently recurrent rearrangements of the PHF1 gene have been reported in OFMT, including typical, atypical, and malignant variants...
  58. Jakate K, Azimi F, Ali R, Lee C, Clarke B, Rasty G, et al. Endometrial sarcomas: an immunohistochemical and JAZF1 re-arrangement study in low-grade and undifferentiated tumors. Mod Pathol. 2013;26:95-105 pubmed publisher
    ..Morphological features, immunoprofile and fluorescence in situ hybridization rearrangements of JAZF1 and PHF1 genes were correlated with tumor category and outcome...
  59. Wang M, Ford M, Zhou C, Seifrid M, Nguyen T, Bazan G. Linear Conjugated Polymer Backbones Improve Alignment in Nanogroove-Assisted Organic Field-Effect Transistors. J Am Chem Soc. 2017;: pubmed publisher
    Three cyclopentadithiophene-difluorophenylene copolymers (named PhF2,3, PhF2,5, and PhF2,6), which differ by the arrangement of fluorines on the phenylene structural unit, were designed and synthesized for the fabrication of organic field-..
  60. Horton J, Upadhyay A, Hashimoto H, Zhang X, Cheng X. Structural basis for human PHF2 Jumonji domain interaction with metal ions. J Mol Biol. 2011;406:1-8 pubmed publisher
    b>PHF2 belongs to a class of ?-ketoglutarate-Fe(2)(+)-dependent dioxygenases. PHF2 harbors a plant homeodomain (PHD) and a Jumonji domain...
  61. Li H, Liefke R, Jiang J, Kurland J, Tian W, Deng P, et al. Polycomb-like proteins link the PRC2 complex to CpG islands. Nature. 2017;549:287-291 pubmed publisher
    ..Polycomb-like (PCL) proteins, such as PHF1, MTF2 and PHF19, are PRC2-associated factors that form sub-complexes with PRC2 core components, and have been ..
  62. Micci F, Gorunova L, Gatius S, Matias Guiu X, Davidson B, Heim S, et al. MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma. Cancer Lett. 2014;347:75-8 pubmed publisher
    ..endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor...
  63. Gatchalian J, Kingsley M, Moslet S, Rosas Ospina R, Kutateladze T. An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3. Epigenetics. 2015;10:467-73 pubmed publisher
    ..The Tudor domains of human homologs PHF1 and PHF19 have been found to recognize trimethylated lysine 36 of histone H3 (H3K36me3); however, the biological ..
  64. Gratuze M, El Khoury N, Turgeon A, Julien C, Marcouiller F, Morin F, et al. Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease. Neurobiol Dis. 2017;98:1-8 pubmed publisher
    ..26-week-old ob/ob mice exhibited tau hyperphosphorylation at multiple tau phospho-epitopes (Tau1, CP13, AT8, AT180, PHF1)...
  65. Panagopoulos I, Mertens F, Griffin C. An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera. Cancer Genet Cytogenet. 2008;185:74-7 pubmed publisher
    ..A JAZF1/PHF1 fusion gene was recently found in two tumors showing an exchange between 6p and 7p rearrangement...
  66. Vaz Meirelles G, Ferreira Lanza D, da Silva J, Santana Bernachi J, Paes Leme A, Kobarg J. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J Proteome Res. 2010;9:6298-316 pubmed publisher
    ..Our findings open new perspectives in the study of hNek6 role in cancer by analyzing its novel interactions in specific pathways in tumor cells, which may provide important implications for drug design and cancer therapy. ..
  67. Perez J, Arcones I, Gomez A, Casquero V, Roncero C. Phosphorylation of Bni4 by MAP kinases contributes to septum assembly during yeast cytokinesis. FEMS Yeast Res. 2016;16: pubmed publisher
    ..Here, we identify new multicopy suppressors of this lethality including Kss1, Pcl1 and Sph1, none of which seems to be linked to the upregulation of chitin synthesis...
  68. Palti Y, Rodriguez M, Gahr S, Hansen J. Evolutionary history of the ABCB2 genomic region in teleosts. Dev Comp Immunol. 2007;31:483-98 pubmed
    ..presence of genes homologous to those located in the human class II (ABCB2, BRD2, psiDAA), extended class II (RGL2, PHF1, SYGP1) and class III (PBX2, Notch-L) regions...
  69. Qin S, Guo Y, Xu C, Bian C, Fu M, Gong S, et al. Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3. Biochem Biophys Res Commun. 2013;430:547-53 pubmed publisher
    ..In this study, we focused on characterizing the histone binding domains of PHF1 and PHF19, and found that the Tudor domains of PHF1 and PHF19 selectively bind to histone H3K36me3...
  70. Saha S, Hu Y, Martin S, Bandyopadhyay S, Russek S, Farb D. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. BMC Pharmacol Toxicol. 2013;14:37 pubmed publisher
    ..demonstrate that PHF1b is an activator at GABRB1, and chromatin immunoprecipitation assays reveal that presence of PHF1 at endogenous Gabrb1 is regulated by GABA(A)R activation...
  71. Strang K, Goodwin M, Riffe C, Moore B, Chakrabarty P, Levites Y, et al. Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau. Acta Neuropathol Commun. 2017;5:58 pubmed publisher
    ..These new reagents will be useful for investigating the progression of tau pathology and further as tools to target the cellular transmission of tau pathology. ..
  72. Gibson M, Gatchalian J, Slater A, Kutateladze T, Poirier M. PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility. Nucleic Acids Res. 2017;45:3767-3776 pubmed publisher
    The Tudor domain of human PHF1 recognizes trimethylated lysine 36 on histone H3 (H3K36me3)...
  73. Musselman C, Avvakumov N, Watanabe R, Abraham C, Lalonde M, Hong Z, et al. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol Biol. 2012;19:1266-72 pubmed publisher
    The PHD finger protein 1 (PHF1) is essential in epigenetic regulation and genome maintenance. Here we show that the Tudor domain of human PHF1 binds to histone H3 trimethylated at Lys36 (H3K36me3). We report a 1...
  74. Kycia I, Kudithipudi S, Tamas R, Kungulovski G, Dhayalan A, Jeltsch A. The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t. J Mol Biol. 2014;426:1651-60 pubmed publisher
    b>PHF1 associates with the Polycomb repressive complex 2 and it was demonstrated to stimulate its H3K27-trimethylation activity...
  75. Gebre Medhin S, Nord K, Möller E, Mandahl N, Magnusson L, Nilsson J, et al. Recurrent rearrangement of the PHF1 gene in ossifying fibromyxoid tumors. Am J Pathol. 2012;181:1069-77 pubmed publisher
    ..Mapping of the 6p21 breakpoint by fluorescence in situ hybridization (FISH) indicated that the PHF1 gene was rearranged in all three cases...
  76. Choi J, Bachmann A, Tauscher K, Benda C, Fierz B, Muller J. DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation. Nat Struct Mol Biol. 2017;: pubmed publisher
    ..PRC2 preferentially binds free DNA with multisecond residence time and midnanomolar affinity. PHF1, a PRC2 accessory protein of the Polycomblike family, extends PRC2 residence time on DNA and chromatin...
  77. Ge Z, Gu Y, Han Q, Sloane J, Ge Q, Gao G, et al. Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia. Epigenomics. 2017;: pubmed publisher
    Clinical significance of plant homeodomain finger 2 (PHF2) expressions is explored in acute lymphoblastic leukemia (ALL) patients.