Genomes and Genes
Gene Symbol: phenylalanine hydroxylase
Description: phenylalanine hydroxylase
Alias: PKU, PKU1, phe-4-monooxygenase, phenylalanine 4-monooxygenase, phenylalanine-4-hydroxylase
Publications215 found, 100 shown here
- [Delayed diagnosis of phenylketonuria as the cause of mental retardation in an adolescent]R Villaverde
, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia,
Rev Neurol 25:1911-6. 1997..On cerebral magnetic resonance changes typical of pheynylketonuria (PKU) were seen...
- The PAH gene, phenylketonuria, and a paradigm shiftCharles R Scriver
Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Hum Mutat 28:831-45. 2007..experience introduces L-phenylalanine, and in nature, where mutations (>500 alleles) occur in the phenylalanine hydroxylase gene (PAH) on chromosome 12q23.2 encoding the L-phenylalanine hydroxylase enzyme (EC 220.127.116.11)...
- Protein metabolism in adult patients with phenylketonuriaMargreet van Rijn
Section of Metabolic Diseases, Department of Pediatrics, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Nutrition 23:445-53. 2007Protein intake recommendations in phenylketonuria (PKU) are frequently the subject of discussion. For healthy adults, the recommended daily allowance (RDA) is 0.8 g.kg(-1)...
- A study on Chinese phenylalanine hydroxylase gene restriction site polymorphismY T Zeng
Laboratory of Medical Genetics, Shanghai Children s Hospital
Sci Sin B 31:1447-53. 1988Human phenylalanine hydroxylase (PAH) cDNA was applied as a hybridization probe to analyzing the following 8 restriction fragment length polymorphisms (RFLP) in the PAH genes of 80 normal and 28 phenylketonuric Chinese patients: BglII, 3...
- Introduction of sapropterin dihydrochloride as standard of care in patients with phenylketonuriaH J Vernon
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Mol Genet Metab 100:229-33. 2010Sapropterin dihydrochloride, a synthetic, stable form of the tetrahydrobiopterin cofactor of phenylalanine hydroxylase, has been shown to reduce plasma phenylalanine (Phe) levels in a significant portion of patients with phenylketonuria (..
- Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemiaMark Sanford
Wolters Kluwer Health Adis, North Shore, Auckland, New Zealand
Drugs 69:461-76. 2009..synthetic formulation of the active 6R-isomer of tetrahydrobiopterin, a naturally occurring cofactor for phenylalanine hydroxylase. In the EU, sapropterin is approved for the treatment of hyperphenylalaninaemia in patients >or=4 ..
- A structural hypothesis for BH4 responsiveness in patients with mild forms of hyperphenylalaninaemia and phenylketonuriaH Erlandsen
The Scripps Research Institute, Department of Molecular Biology and Institute for Childhood and Neglected Diseases, La Jolla, CA 92037, USA
J Inherit Metab Dis 24:213-30. 2001Deficiencies in the human enzyme phenylalanine hydroxylase (PAH) due to mutations in the PAH gene (PAH) result in the inborn error of metabolism phenylketonuria (PKU)...
- Dietary glycomacropeptide supports growth and reduces the concentrations of phenylalanine in plasma and brain in a murine model of phenylketonuriaDenise M Ney
Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
J Nutr 138:316-22. 2008Phenylketonuria (PKU) is a genetic disorder caused by deficiency of phenylalanine hydroxylase (PAH) that requires life-long adherence to a low-phenylalanine (Phe) diet...
- Reversal of gene expression profile in the phenylketonuria mouse model after adeno-associated virus vector-mediated gene therapyHyun Jeong Oh
Department of Biomedical Sciences, National Institute of Health, Seoul 122 701, Republic of Korea
Mol Genet Metab 86:S124-32. 2005Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by phenylalanine hydroxylase (PAH) deficiency...
- Phenylketonuria in Iranian population: a study in institutions for mentally retarded in IsfahanSadeq Vallian
Department of Biology, Faculty of Science, Division of Genetics, Isfahan University, Hezarjerib Street, Iran
Mutat Res 526:45-52. 2003b>Phenylalanine hydroxylase (PAH) deficiency is caused by mutations in the PAH gene (12q22-q24) resulting in a primary deficiency of the PAH enzyme activity, intolerance to the dietary intake of phenylalanine (Phe) and production of the ..
- Protective effect of recombinant adeno-associated virus 2/8-mediated gene therapy from the maternal hyperphenylalaninemia in offsprings of a mouse model of phenylketonuriaSung Chul Jung
Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, Korea
J Korean Med Sci 23:877-83. 2008Phenylketonuria (PKU) is an autosomal recessively inherited metabolic disorder caused by a deficiency of phenylalanine hydroxylase (PAH)...
- [Ten novel mutations in the phenylalanine hydroxylase gene identified in Chinese patients with phenylketonuria]Fang Song
Department of Genetics, Capital Institute of Pediatrics, Beijing 100020, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:142-4. 2003To study the molecular basis of the phenylalanine hydroxylase (PAH) gene mutation in Chinese patients with phenylketonuria (PKU).
- [Mutation spectrum of phenylalanine hydroxylase gene in patients with phenylketonuria in Tianjin and surrounding areas of Northern China]Li Song
Pediatric Research Institute, Tianjin Children s Hospital, Tianjin, 300074 P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:7-12. 2010To investigate the characteristics of the phenylalanine hydroxylase (PAH) gene mutations in patients with phenylketonuria (PKU) in Tianjin and surrounding area, in order to provide basic information for genetic counseling and prenatal ..
- Response of patients with phenylketonuria in the US to tetrahydrobiopterinReuben Matalon
Department Pediatrics, University of Texas Medical Branch, Galveston TX, USA
Mol Genet Metab 86:S17-21. 2005..To determine the incidence of BH4 responding PKU patients in the United States and characterize their phenylalanine hydroxylase (PAH) mutations, a study was undertaken at UTMB in Galveston and the Children's Hospital of Los Angeles ..
- Molecular characterization of phenylketonuria in Japanese patientsY Okano
Department of Pediatrics, Osaka City University Medical School, Japan
Hum Genet 103:613-8. 1998We characterized phenylalanine hydroxylase (PAH) genotypes of Japanese patients with phenylketonuria (PKU) and hyperphenylalaninemia (HPA)...
- Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skinRikke Christensen
Department of Human Genetics, University of Aarhus, Aarhus, Denmark
Exp Dermatol 14:535-42. 2005..Circulating phenylalanine is normally cleared by phenylalanine hydroxylase (PAH) expressed in the liver...
- New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2, a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiencyFlorian B Lagler
Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria
Biochem Pharmacol 80:1563-71. 2010Phenylketonuria (PKU), an autosomal recessive disease with phenylalanine hydroxylase (PAH) deficiency, was recently shown to be a protein misfolding disease with loss-of-function...
- [The maternal phenylketonuria syndrom--still current problem]Bozena Didycz
Klinika Chorób Dzieci Katedry Pediatrii, Uniwersytet Jagielloński Collegium Medium w Krakowie
Przegl Lek 66:4-10. 2009..Being untreated or insufficiently treated phenylketonuria (PKU) sometimes leads to irreversible damage of mielin...
- Expression of phenylalanine hydroxylase (PAH) in erythrogenic bone marrow does not correct hyperphenylalaninemia in Pah(enu2) miceCary O Harding
Oregon Health and Science University, Portland, OR 97239 2998, USA
J Gene Med 5:984-93. 2003..Our specific hypothesis was that phenylalanine hydroxylase (PAH) expressed in bone marrow would lower blood phenylalanine levels in hyperphenylalaninemic Pah(enu2) ..
- In vivo studies of phenylalanine hydroxylase by phenylalanine breath test: diagnosis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiencyYoshiyuki Okano
Department of Pediatrics, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
Pediatr Res 56:714-9. 2004Tetrahydrobiopterin (BH4)-responsive phenylalanine hydroxylase (PAH) deficiency is characterized by reduction of blood phenylalanine level after a BH4-loading test...
- Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency, state of the artLeo J M Spaapen
Department of Biochemical Genetics, Academic Hospital, Maastricht, The Netherlands
Mol Genet Metab 78:93-9. 2003Since 1999 an increasing number of patients with phenylalanine hydroxylase (PAH) deficiency are reported to be able to decrease their plasma phenylalanine (Phe) concentrations after a 6R-tetrahydrobiopterin (BH(4)) challenge...
- Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania majorLon Fye Lye
Department of Molecular Microbiology, Box 8230, Washington University Medicine School, 600 S Euclid Ave, St Louis, MO 63110, USA
Mol Biochem Parasitol 175:58-67. 2011..Here we explored the consequences of genetic manipulation of the sole L. major phenylalanine hydroxylase (PAH) to explore whether it could account for the Leishmania H(4)B requirement. L...
- Phenylalanine hydroxylase activity and expression in chicks subjected to phenylalanine imbalance or phenylalanine toxicityF M Lartey
Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
Poult Sci 88:774-83. 2009..The increased activity does not involve changes in PAH mRNA. The effects of IAA - Phe on plasma Phe concentrations appear to be independent of hepatic PAH activity as measured in vitro...
- Detection of Heterozygous Carriers of PKU in Egypt: Successful Application of a Simple Biochemical MethodEbtesam M Abdalla
Human Genetics Department, Medical Research Institute, University of Alexandria
J Egypt Public Health Assoc 83:239-54. 2008..together with the difficulty of the molecular testing due to the large number of mutations in the phenylalanine hydroxylase (PAH) gene has resulted in continued effort to develop an accurate procedure to discriminate the ..
- Sapropterin therapy increases stability of blood phenylalanine levels in patients with BH4-responsive phenylketonuria (PKU)Barbara K Burton
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
Mol Genet Metab 101:110-4. 2010..correlated with IQ and is a better predictor of IQ in early and continuously treated patients with phenylketonuria (PKU) than mean blood phenylalanine levels...
- The Resource Mothers Study of Maternal Phenylketonuria: preliminary findingsF Rohr
Children s Hospital, Boston, Massachusetts 02115, USA
J Inherit Metab Dis 27:145-55. 2004Women with phenylketonuria (PKU) must follow a strict low-phenylalanine diet during pregnancy in order to protect the fetus from the deleterious effects of high maternal blood phenylalanine...
- The impact of phenylketonuria on folate metabolismMark Lucock
Academic Unit of Paediatrics and Obstetrics and Gynaecology, D Floor, Clarendon Wing, Leeds General Infirmary, University of Leeds, West Yorkshire LS2 9NS, UK
Mol Genet Metab 76:305-12. 2002Several reports indicate that biopterin and folate pathways may interact. We examined folate metabolism in PKU patients where hyperphenylalaninaemia leads to a likely excess of THB...
- Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populationsJ R Kidd
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Hum Genet 66:1882-99. 2000Because defects in the phenylalanine hydroxylase gene (PAH) cause phenylketonuria (PKU), PAH was studied for normal polymorphisms and linkage disequilibrium soon after the gene was cloned...
- Correction of murine PKU following AAV-mediated intramuscular expression of a complete phenylalanine hydroxylating systemZhaobing Ding
Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Zurich, Switzerland
Mol Ther 16:673-81. 2008Phenylketonuria (PKU) caused by phenylalanine hydroxylase (PAH) deficiency leads to toxic accumulation of phenylalanine (Phe)...
- Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiencyMarcel R Zurflüh
Division of Clinical Chemistry and Biochemistry, University Children s Hospital, Zurich, Switzerland
Hum Mutat 29:167-75. 2008Mutations in the phenylalanine hydroxylase (PAH) gene result in phenylketonuria (PKU)...
- Sequence and expression of the Drosophila phenylalanine hydroxylase mRNAG Morales
Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
Gene 93:213-9. 1990We report the cloning, nucleotide (nt) sequence and expression of the cDNA (pah) encoding phenylalanine hydroxylase (PAH) of Drosophila melanogaster. The strong hybridization signals observed in genomic blots when D...
- Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardationL Zagreda
Center for Developmental Cognitive Neuroscience, Eunice Kennedy Shriver Center, Waltham, Massachusetts 02452, USA
J Neurosci 19:6175-82. 1999b>Phenylalanine hydroxylase (Pah)-deficient "PKU mice" have a mutation in the Pah gene that causes phenylketonuria (PKU) in humans. PKU produces cognitive deficits in humans if it is untreated...
- Tetrahydrobiopterin responsiveness after extended loading test of 12 Danish PKU patients with the Y414C mutationJytte Bieber Nielsen
Center for PKU, The Kennedy Center, Glostrup, Denmark
J Inherit Metab Dis 33:9-16. 2010..metabolic disease characterized by phenylalanine (Phe) accumulation due to defects in the enzyme phenylalanine hydroxylase (PAH). Phe accumulation can lead to cognitive impairment...
- [Comparison of genotype and intellectual phenotype in untreated phenylketonuric children]L Yuan
Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005 P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:297-9. 1998..Although classical PKU is defined as that the hepatic phenylalanine hydroxylase (PAH) activity ranges 0-1% of normal enzyme, the untreated PKU patients show a wide range of ..
- Blood phenylalanine concentrations in patients with PAH-deficient hyperphenylalaninaemia off diet without and with three different single oral doses of tetrahydrobiopterin: assessing responsiveness in a model of statistical process controlM Lindner
Division of Metabolic Disorders, Department of General Paediatrics, University Children s Hospital, Heidelberg, Germany
J Inherit Metab Dis 32:514-22. 2009..BH(4)) cofactor loading is a standard procedure to differentiate defects of BH(4) metabolism from phenylalanine hydroxylase (PAH) deficiency...
- Clinical analysis of West syndrome associated with phenylketonuriaZ Zhongshu
Pediatric Department, China Japan Friendship Hospital, Ying Hua Dong Lu 1, He Ping Li, Beijing 100029, People s Republic of China
Brain Dev 23:552-7. 2001To explore the incidence and clinical characteristics of West syndrome associated with phenylketonuria (WS-PKU) and significance of early combination therapy of low phenylalanine (PHE) diet and anticonvulsants (antiepileptic drugs, AEDs) ..
- Behaviour and school achievement in patients with early and continuously treated phenylketonuriaB A Stemerdink
Department of Developmental, State University Groningen, The Netherlands
J Inherit Metab Dis 23:548-62. 2000Thirty patients with early and continuously treated phenylketonuria (PKU) between 8 and 20 years of age were compared with 30 controls, matched individually for age, sex, and educational level of both parents, on behaviour rating scales ..
- Metabolic basis of sexual dimorphism in PKU mice after genome-targeted PAH gene therapyLi Chen
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Mol Ther 15:1079-85. 2007..in targeted insertion of transgenes into mammalian genomes, and its use in the delivery of murine phenylalanine hydroxylase (PAH) complementary DNA (cDNA) into the hepatocytes of male phenylketonuria (PKU) mice, leading to a ..
- Intake and blood levels of fatty acids in treated patients with phenylketonuriaP B Acosta
Medical Department, Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215 1724, USA
J Pediatr Gastroenterol Nutr 33:253-9. 2001Investigators in Italy and Spain have suggested that therapy for patients with phenylketonuria (PKU) may result in essential fatty acid (EFA) deficiency...
- Outcome at age 4 years in offspring of women with maternal phenylketonuria: the Maternal PKU Collaborative StudyS E Waisbren
Genetic Service, Children s Hospital, Boston, Mass 02115, USA
JAMA 283:756-62. 2000Untreated maternal phenylketonuria (PKU) increases risk for developmental problems in offspring. The extent to which this risk is reduced by maternal dietary therapy at various stages of pregnancy is not known.
- Normal infant by a gestational carrier for a phenylketonuria mother: alternative therapyRobert O Fisch
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Mol Genet Metab 82:83-6. 2004The consequences of pregnancies in untreated phenylketonuria (PKU) mothers are a high incidence of spontaneous abortion, intrauterine growth retardation with microcephaly, congenital malformations, and abnormal intellectual development...
- Response of phenylketonuria to tetrahydrobiopterinKimberlee Michals-Matalon
Department of Health and Human Performance, University of Houston, Houston, TX 77204, USA
J Nutr 137:1564S-1567S; discussion 1573S-1575S. 2007A favorable response, indicated by decline of blood phenylalanine (Phe) in patients with phenylketonuria (PKU), to orally administered 6-R-L-erythro-5, 6, 7, 8-tetrahydrobiopterin (BH4) has been reported in many countries following the ..
- 1H MR chemical shift imaging detection of phenylalanine in patients suffering from phenylketonuria (PKU)Paul E Sijens
Department of Radiology, University Hospital Groningen, Hanzeplein 1, P O Box 30001, Groningen, The Netherlands
Eur Radiol 14:1895-900. 2004..voxel methods were used in previous MR spectroscopy studies of phenylalanine (Phe) levels in phenylketonuria (PKU) patients. In this study, apparent T2 relaxation time of the 7...
- Plasma phenylalanine concentrations are associated with hepatic iron content in a murine model for phenylketonuriaSareen S Gropper
Department of Nutrition and Food Science, 328 Spidle Hall, Auburn University, Auburn, AL 36849, USA
Mol Genet Metab 82:76-82. 2004Individuals with phenylketonuria (PKU) have been reported to have altered trace mineral status...
- Are neuropsychological impairments in children with early-treated phenylketonuria (PKU) related to white matter abnormalities or elevated phenylalanine levels?Peter J Anderson
Critical Care and Neurosciences, Murdoch Childrens Research Institute, Melbourne, Australia
Dev Neuropsychol 32:645-68. 2007..to enhance our understanding of neuropsychological functioning in children with early-treated phenylketonuria (PKU) and assess the relative impact of white matter abnormalities (WMA) and neurotransmitter deficiencies on cognitive ..
- Screening programme for phenylketonuria in the Gaza Strip: evaluation and recommendationsAbdel Nasser K Abu Shahla
Biology Department, Al Azhar University, Gaza, Palestine
J Trop Pediatr 50:101-5; discussion 106. 2004Phenylketonruia (PKU) is an inherited metabolic disorder that results in progressive mental retardation...
- Polycyclic aromatic hydrocarbons in the South American environmentRicardo Barra
Aquatic Systems Research Unit, EULA Chile Environmental Sciences Center, Barrio Universitario s n, University of Concepcion, P O Box 160 C, Concepcion, Chile
Rev Environ Contam Toxicol 191:1-22. 2007..In these countries, this type of analysis needs to be performed, and the laboratory capacity needs to be built to assure the accomplishment of these objectives...
- Purification to homogeneity of the major "4S" PAH binding protein from "non responsive" DBA/2N mouse liver by affinity chromatographyM T Masucci
Institute of General Pathology and Oncology, I Medical School, University of Naples, Italy
Tumori 75:202-10. 1989..On electrophoresis in SDS gels, the purified protein migrated as a single protein band with an apparent molecular weight of 40,000...
- [Polar neutral organic compounds (POCN) in city aerosols. 2. Measuring of emissions from domestic fuel and vehicle exhaust and from immission particles in Berlin (West)]H J Moriske
Zentralbl Bakteriol Mikrobiol Hyg B 185:72-104. 1987..So, for coal firing emissions, higher concentrations for phenanthrene, benzo(a)-pyrene and dibenz(a.h)anthracene (for PAH) and 9-fluorenone (for POCN) were gained.(ABSTRACT TRUNCATED AT 400 WORDS)..
- "4S" polycyclic aromatic hydrocarbon binding protein. Its role as a benzo(a) pyrene cytosolic carrier to the microsomes of DBA/2N mouse liverM T Masucci
Institute of General Pathology, Ist Medical School, University of Naples, Italy
Tumori 75:211-6. 1989..Thus, this protein is able to transfer benzo(a)pyrene to the microsomal metabolization sites and to facilitate the release of oxidized products and, presumably, bind them...
- [Prevention by L-dopa of early renal consequences of diabetes induced by streptozocin in rats]B Vailly
Institut de Pharmacologie (URA DO 589 CNRS, , CHRU, Strasbourg
Arch Mal Coeur Vaiss 83:1259-62. 1990..3 +/- 0.07, n = 14, versus 0.93 +/- 0.05 ml/min.g kidney weight in non-diabetic controls, p less than 0.001) and an increase in filtration fraction (52.4 +/- 5.1 versus 32.1 +/- 1.7%, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)..
- Effects of oral calcium, potassium, digoxin, and nifedipine on natriuresis in normal humansF C Luft
Department of Medicine, Indiana University School of Medicine, Indianapolis
Am J Hypertens 2:14-9. 1989..Nifedipine may also uncouple renin from aldosterone. Oral calcium supplementation and sodium-potassium dependent ATPase inhibition did not facilitate natriuresis...
- Polycyclic aromatic hydrocarbons in edible fats and oils: occurrence and analytical methodsS Moret
Department of Food Science, University of Udine, Italy
J Chromatogr A 882:245-53. 2000....
- Influence of vegetation on the in situ bacterial community and polycyclic aromatic hydrocarbon (PAH) degraders in aged PAH-contaminated or thermal-desorption-treated soilAurélie Cébron
Faculte des Sciences, LIMOS, Nancy Universite, CNRS UMR 7137, 54506 Vandoeuvre les Nancy Cedex, France
Appl Environ Microbiol 75:6322-30. 2009..The GP PAH-RHD(alpha) bacterial gene proportion decreased in the NM-BS plots but stayed constant or increased under vegetation influence (NM-SV, NM-Ms, and TD-Ms)...
- Static subcritical water extraction with simultaneous solid-phase extraction for determining polycyclic aromatic hydrocarbons on environmental solidsS B Hawthorne
Energy and Environmental Research Center, University of North Dakota, Grand Forks 58202, USA
J Chromatogr A 886:237-44. 2000..The method gives good quantitative agreement with standard Soxhlet extraction, and with certified reference materials for PAH concentrations on soil, sediment (SRM 1944), and air particulate matter (SRM 1649a)...
- Renal functional effects of prostaglandin synthesis inhibition in patients with insulin-dependent diabetes mellitus of long duration without nephropathyT Linne
Department of Pediatrics, Karolinska Institute, St Goran s Hospital, Stockholm, Sweden
Horm Metab Res 23:383-6. 1991..14.5 +/- 10.6 and 12.9 +/- 8.3 in controls). We conclude that the hyperfiltration in this stage of IDDM does not appear to be PG dependent, and that PGSI does not give any immediate effects on the albumin excretion...
- [Polar neutral organic compounds (POCN) in city aerosols. 3. Comparative studies of emission and immission particles in West Berlin]H J Moriske
Zentralbl Bakteriol Mikrobiol Hyg B 185:452-68. 1988..The concentration of the nitro-groups containing substances (included in the POCN-fraction) amounted here generally to higher values in comparison with the vehicle emissions (except of 1-nitropyrene).(ABSTRACT TRUNCATED AT 400 WORDS)..
- Genotoxic potential of Polycyclic Aromatic Hydrocarbons-coated onto airborne Particulate Matter (PM 2.5) in human lung epithelial A549 cellsSylvain Billet
LCE EA 2598, Toxicologie Industrielle et Environnementale, Universite du Littoral Cote d Opale, Maison de la Recherche en Environnement Industriel de Dunkerque 2, 189A, Avenue Maurice Schumann, 59140 Dunkerque, France
Cancer Lett 270:144-55. 2008..We also concluded that, in the human lung epithelial cell model we used, and in the experimental conditions we chose, bulky-DNA adduct formation was apparently not a major factor involved in the Dunkerque City's PM 2.5-induced toxicity...
- [The role of glucocorticoids in the cardiovascular adaptation to sodium restriction in the rat]J P Grunfeld
INSERM Unité 90, Hopital Necker, Paris
Arch Mal Coeur Vaiss 80:822-5. 1987..In conclusion, endogenous Gs contribute to blood pressure control in salt-restricted rats, possibly by increasing vascular reactivity to catecholamines and angiotensin...
- Biodegradation aspects of polycyclic aromatic hydrocarbons (PAHs): a reviewA K Haritash
Department of Environmental Science and Engineering, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India
J Hazard Mater 169:1-15. 2009..An integrated approach of physical, chemical, and biological degradation may be adopted to get synergistically enhanced removal rates and to treat/remediate the contaminated sites in an ecologically favorable process...
- Endothelin receptor antagonists for pulmonary arterial hypertensionC Liu
Monash University, Australasian Cochrane Centre, Locked Bag 29, Clayton, Victoria, Australia 3168
Cochrane Database Syst Rev 3:CD004434. 2006..PAH can also be secondary to chronic hypoxic lung disease as part of the "cor-pulmonale" syndrome, and also secondary to left sided heart disease, but these conditions are usually distinguished from those listed here...
- [Effects of diltiazem on arterial pressure and renal function in renal transplanted and cyclosporin A treated subjects. Results after 3 months of a prospective study]C Guerin
, , CHU de Saint-Etienne, Saint-Priest en Jarez, France
Arch Mal Coeur Vaiss 82:1223-7. 1989..73 m2; at 3 months 13/14 (93 p. 100) vs 12/15 (80 p. 100) of the grafts are functioning (NS), GFR (34 +/- 17 vs 33 +/- 10) and ERBF (242 +/- 90 vs 236 +/- 117) are not different.(ABSTRACT TRUNCATED AT 250 WORDS)..
- [Renal function during stress in hypertensive patients]J P Fauvel
, , Lyon
Arch Mal Coeur Vaiss 84:1195-9. 1991..In the long-term, the increased sodium resorption during stress could contribute to the development and the persistence of essential hypertension...
- [Effect of cyclosporin A on blood pressure and renal hemodynamics in insulin dependent diabetes]T Hannedouche
, , Paris
Arch Mal Coeur Vaiss 81:221-3. 1988....
- DNA adduct formation in mammalian cell cultures by polycyclic aromatic hydrocarbons (PAH) and nitro-PAH in coke oven emission extractJ Topinka
Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20, Prague 4, Czech Republic
Mutat Res 419:91-105. 1998..Using DNA adduct analysis in rat hepatocytes (+/-pretreatment with TCDD) and in NCI-H322 and in V79NH cells offers a promising approach to determine the genotoxic activity of PAH and nitro-PAH in any complex environmental samples...
- Mutagenicity and contents of polycyclic aromatic hydrocarbons in used and recycled motor oilsE Clonfero
Istituto di Medicina del Lavoro della Università di Padova, Italy
Mutat Res 368:283-91. 1996....
- Evidence-based pharmacologic management of pulmonary arterial hypertensionNeal Benedict
Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Clin Ther 29:2134-53. 2007..Pulmonary arterial hypertension (PAH) is a debilitating chronic disorder of the pulmonary vasculature characterized by elevated mean pulmonary arterial pressure, right-sided heart failure, and early mortality...
- Novel approach to the analysis and use of fullerenes in capillary electrophoresisJ M Treubig
Department of Chemistry, University of Rhode Island, Kingston 02881, USA
J Chromatogr A 873:257-67. 2000..The preliminary results using C60-MEKC with SDS were compared to those obtained with MEKC with SDS. The capillary electrophoretic separations were performed in 10 mM borate-phosphate buffer with 100 mM SDS at pH 9.5...
- PAH metabolites in bile fluids of dab (Limanda limanda) and flounder (Platichthys flesus): spatial distribution and seasonal changesUlrike Kammann
Federal Research Centre for Fisheries, Institute for Fishery Ecology, Palmaille 9, 22767 Hamburg, Germany
Environ Sci Pollut Res Int 14:102-8. 2007....
- [Nitrated polycyclic aromatic hydrocarbons (nitro-PAH) in suspended particles in the atmosphere. 1. Fractionation and analytic detection]H Schleibinger
Zentralbl Bakteriol Mikrobiol Hyg B 187:44-55. 1988..Thus, depending on the preconcentration factor (up to 100 m3 per 200 microliter) these compounds could be detected in the range from 0.5-5 pg/m3...
- Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney. IV. Specificity: mono- and polysubstituted benzene analogsK J Ullrich
Max Planck Institut fur Biophysik, Frankfurt Main, Federal Republic of Germany
Pflugers Arch 413:134-46. 1988..The sulfate transporter interacts with molecules which have neighbouring electronegative charge accumulation...
- Comparison between photo-induction and microsomal activation of polycyclic hydrocarbons with different oncogenic potencyG Prodi
Centro di Cancerogenesi Chimica, Istituto di Cancerologia, , Italy
Toxicol Pathol 12:185-8. 1984..Therefore, a certain degree of correlation between the extent of DNA binding and oncogenic potency of the chemicals seemed to exist. Polynucleotide labeling was always higher than DNA labeling...
- Accelerated versus slowly progressive forms of puberty in girls with precocious and early puberty. Gonadotropin suppressive effect and final height obtained with two different analogsRoberto Lanes
Pediatric Endocrine Unit, Hospital de Clinicas Caracas, Caracas, Venezuela
J Pediatr Endocrinol Metab 17:759-66. 2004..To determine the effect of GnRH analog treatment on the final height of treated patients and compare the effect of two different analogs on gonadotropin suppression and final height...
- [Biological monitoring at the work site]N Winker
Allgemeine Unfallversicherungsanstalt, , Wien, Osterreich
Pneumologie 44:875-9. 1990..In addition, the problems of the test concept to evaluate the effects of exposure to polycyclic aromatic hydrocarbons by means of determining DNA-PAH adducts are discussed...
- Reassessment of the predictive value of the postural stimulation test in primary aldosteronismR G Fontes
San Francisco General Hospital Medical Center, CA
Am J Hypertens 4:786-91. 1991..Among these false-positive results there were the nine cases of PAH where the hypertension could be ameliorated or cured by partial removal of hyperplastic adrenal tissue.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Detection of DNA damage in fish Oreochromis mossambicus induced by co-exposure to phenanthrene and nitrite by ESI-MS/MSSolimabi Wahidulla
Bio Organic Laboratory, Chemical Oceanography Division, National Institute of Oceanography, CSIR, Dona Paula, Goa, 403 004, India
Environ Sci Pollut Res Int 17:441-52. 2010....
- cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expressionG H Xiao
Department of Biochemistry, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
J Biol Chem 272:3238-45. 1997....
- Concentrations and bioaccessibility of polycyclic aromatic hydrocarbons in wastewater-irrigated soil using in vitro gastrointestinal testSardar Khan
Department of Soil Environmental Science, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
Environ Sci Pollut Res Int 15:344-53. 2008..This study was conducted to investigate the level of PAH contamination and oral bioaccessibility in surface soils, using physiologically based in vitro gastro-intestinal tests regarding both gastric and small intestinal conditions...
- Diastolic function of the heart in mixed connective tissue diseaseJudit Vegh
3rd Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Clin Rheumatol 26:176-81. 2007..In the case of MCTD patients complicated with PAH, the signs of the right ventricle function impairment proved to be permanent...
- Mitogen induced proliferative responses of lymphocytes from spot (Leiostomus xanthurus) exposed to polycyclic aromatic hydrocarbon contaminated environmentsM Faisal
Virginia Institute of Marine Science, School of Marine Science, College of William and Mary, Gloucester Point 23062
Immunopharmacol Immunotoxicol 13:311-27. 1991..These results suggest that the proliferative responses of fish lymphocytes to mitogens may be a potentially sensitive biomarker of exposure to, and effects of xenobiotics...
- Distribution of n-alkanes, polynuclear aromatic hydrocarbons and nitrated polynuclear aromatic hydrocarbons between the fine and coarse fractions of inhalable atmospheric particulatesA Cecinato
Istituto sull'Inquinamento Atmosferico CNR, Monterotondo Scalo RM, Italy
J Chromatogr A 846:255-64. 1999..Moreover, nitrated PAHs had varied distributions, according to the origin of their occurrence in the atmosphere; in fact, congeners of photochemical origin accumulated more in fine particles than those released by primary sources...
- [Influence of acute administration of ramipril on the excretion of uric acid]M Labeeuw
, , CNRS UA 1177, , Lyon
Arch Mal Coeur Vaiss 80:870-4. 1987..The simultaneous changes in FeAU and in ACE activity indicate that the effect on uric acid excretion is presumably due to the fall in angiotensin concentration...
- Renal artery clipping attenuates the progression of adriamycin nephropathyA L Balbi
Department of Medicine, Botucatu Medical School (UNESP, , Brazil
Am J Hypertens 11:1124-8. 1998..05 v nonclipped). The data suggest that diminished perfusion pressure of the clipped kidney, by decreasing the intraglomerular pressure, protects the glomerulus from damage and attenuates the evolution of adriamycin nephropathy...
- Application of solid-phase extraction discs with a glass fiber matrix to fast determination of polycyclic aromatic hydrocarbons in waterI Urbe
J Chromatogr A 778:337-45. 1997..They can concentrate volume samples of up to 1 l, with PAH recoveries at the level of 1-2 ng/l higher than 80 +/- 10% and detection limits of between 0.1-2 ng/l, depending on the compound studied...
- Variation in the response of T cells to concanavalin A after in vitro exposure to benzo[A]pyrene and 2-aminofluoreneM Lee
Department of Microbiology/Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
Immunopharmacol Immunotoxicol 18:309-21. 1996..Studies with beta NF indicate that this P-450 inducer enhances the anti-proliferative effect of BP, while it abolishes this effect of AF...
- Mechanisms of renal tubular defects in old ageA S Dontas
Department of Clinical Therapeutics, University of Athens, and Centre of Studies of Age-related Changes in Man, Athens, Greece
Postgrad Med J 48:295-303. 1972..Finally, it appears that renal infection aggravates the larger glomerular and proximal tubular deficits observed in non-infected men: it depresses distal tubular function equally in both sexes...
- Application of micro-scale sealed vessel thermal desorption-gas chromatography-mass spectrometry for the organic analysis of airborne particulate matter: linearity, reproducibility and quantificationD Waterman
Division of Life Sciences, King's College London, UK
J Chromatogr A 912:143-50. 2001..62 mg kg(-1) (< or = 11%)]. We show linearity for a series of 10 n-alkanes and 10 polycyclic aromatic hydrocarbons (PAHs) in the SRM. The technique is also shown to be quantifiable (PAH concentrations typically 4-6 mg kg(-1))...
- Separation of polycyclic aromatic hydrocarbon metabolites by gamma-cyclodextrin-modified micellar electrokinetic chromatography with laser-induced fluorescence detectionC J Smith
Division of Environmental Health Laboratory Sciences, National Center for Environmental Health, US Department of Health and Human Services, Atlanta, GA 30341, USA
J Chromatogr A 803:241-7. 1998..08-0.5) x 10(-15) mol range. To our knowledge, this is the first report of the separation of metabolic products of PAHs (and several positional isomers) using gamma-CD and micellar electrokinetic chromatography...
- [Hypertension induced by cyclosporin A in insulin-dependent diabetic patients. A one-year follow-up]T Hannedouche
, , Paris
Arch Mal Coeur Vaiss 83:1347-50. 1990..In conclusion: 1) CyA-induced increase in blood pressure paralleled that in RVR at M3 and decreased sodium excretion at M12. 2) There was a dissociation between MAP and GFR changes after 12 months of treatment with CyA...
- Blood pressure and renal blood flow responses to dietary calcium and sodium intake in humansG M Rich
Endocrinology/Hypertension Division, Brigham and Women's Hospital, Boston, MA 02115
Am J Hypertens 4:642S-645S. 1991..05 between groups). These data suggest that a low calcium diet may contribute to the phenomenon of salt sensitivity in a white population. The low calcium intake appears to affect both the systemic and renal vasculature...
- Validation of an analytical procedure for polychlorinated biphenyls, coplanar polychlorinated biphenyls and polycyclic aromatic hydrocarbons in environmental samplesA Jaouen-Madoulet
IFREMER, Centre de Brest, , , , France
J Chromatogr A 886:153-73. 2000..This method allows the measurement of these contaminants in biota and sediment at trace levels as low as 1 pg g(-1) for coplanar PCBs with a precision better than 20%...
- Polycyclic aromatic hydrocarbon 13C/12C ratio measurement in petroleum and marine sediments application to standard reference materials and a sediment suspected of contamination from the Erika oil spillL Mazeas
, UPRESA 5472, , Talence, France
J Chromatogr A 923:165-76. 2001..This analytical procedure has then been successfully applied to confirm the contamination of a sediment by the petroleum product spilled by the Erika tanker after its wreck on 12 December 1999 close to the Atlantic Coast of France...
- Hydrophobic interaction electrokinetic chromatography for the separation of polycyclic aromatic hydrocarbons using non-aqueous matricesJ T Koch
Department of Chemistry, Furman University, Greenville, SC 29613-1120 USA
J Chromatogr A 914:223-31. 2001..Solid-phase microextraction is demonstrated to be an effective sample preparation technique for extraction/preconcentration of PAHs from water into methanol run buffer prior to injection...
- Stability and determination of aflatoxins by high-performance liquid chromatography with amperometric detectionM P Elizalde-González
Centro de Quimica, Instituto de Ciencias, Universidad Autónoma de Puebla Apdo, Mexico
J Chromatogr A 828:439-44. 1998..3 mmol/l, respectively. Sensitivity varied between 7 and 10 ng for the different aflatoxins. The combination of different HPLC detectors in the analysis of these compounds was applied to investigate the stability of aflatoxins G1 and B2...
- Laterally attached liquid crystalline polymers as stationary phases in reversed-phase high-performance liquid chromatography. II. Optimization of the molecular parameter of the polymerF Gritti
, B.P. 108, Talence, France
J Chromatogr A 897:131-43. 2000..The results show that the combination of a long spacer and long terminal chains, which generates a smectic phase in the polymer bulk, leads to the best chromatographic performances towards planarity and shape recognition for PAH solutes...
- Influence of the para-aminohippuric acid analysis method on the net hepatic flux of nutrients in lactating cowsJ M Rodríguez-López
INRA, UMR 1213, Unité Mixte de Recherches sur les Herbivores, F 63122 Saint Genes Champanelle, France
J Anim Sci 92:1074-82. 2014..05). In conclusion, our results highlight the importance of including a deacetylation step in the pAH analysis method in cattle studies and of using plasma as standard matrix. ..
- Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in miceLi Li
Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A and M Health Science Center, 1901 South 1st St, Bldg 205, Temple, TX
Hypertension 63:1260-9. 2014....
- Monitoring of polycyclic aromatic hydrocarbons (PAH) in food supplements containing botanicals and other ingredients on the Dutch marketM J Martena
a Food and Consumer Product Safety Authority VWA, PO Box 2168, NL 5600 CD Eindhoven, The Netherlands
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 28:925-42. 2011..Regular control of EFSA indicator PAH levels in food supplements may prove a way forward to reduce further the intake of PAH from food...
- PAH effects on meio- and microbial benthic communities strongly depend on bioavailabilityJ Fredrik Lindgren
Department of Shipping and Marine Technology, Chalmers University of Technology, 41296 Gothenburg, Sweden Electronic address
Aquat Toxicol 146:230-8. 2014....
- The determination of polycyclic aromatic hydrocarbons in the urine of non-smoking Polish pregnant womenKinga Polanska
Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 8 Teresy Str, 91 348 Lodz, Poland Electronic address
Sci Total Environ 487:102-9. 2014..This higher PAH exposure level probably poses a significant health risk for the newborns and young children and will require further attention in the future...
- Serial changes of serum endostatin and angiopoietin-1 levels in preterm infants with severe bronchopulmonary dysplasia and subsequent pulmonary artery hypertensionDo Hyun Kim
Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea
Neonatology 106:55-61. 2014..In bronchopulmonary dysplasia (BPD), disrupted angiogenesis may result from an imbalance between pro- and anti-angiogenic factors triggered by inflammation, leading to the late development of pulmonary artery hypertension (PAH)...
- Genetic Reconstitution for PhenylketonuriaSavio Woo; Fiscal Year: 2006..is a recessive monogenic disorder in amino acid metabolism that results from a deficiency of hepatic phenylalanine hydroxylase (PAH), and it predisposes affected individuals to severe and permanent mental retardation...
- Augmented Phenylalanine Clearance by Muscles as Novel Therapy for PhenylketonuriaCary O Harding; Fiscal Year: 2013..More specifically, the investigators will focus their efforts upon phenylalanine hydroxylase (PAH)-deficient Pahenu2 mice, a model of human phenylketonuria (PKU), and will evaluate expression of a ..
- BIOLOGICAL OXIDATION OF PHENYLALANINE BY NONHEME IRONJohn Caradonna; Fiscal Year: 2003..elucidate the chemical and physical properties of the mononuclear non-heme iron dependent metalloenzyme, phenylalanine hydroxylase (PAH, phenylalanine 4-monooxygenase, E.C. 18.104.22.168)...
- Non-Invasive Blood Phenylalanine MonitorABDEL HALIM GHANEM; Fiscal Year: 2002Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH). Without PAH, the patient with PKU cannot metabolize phenylalanine (PHE) to tyrosine...
- Novel therapy for monoamine neurotransmitter deficiency in PKUCary O Harding; Fiscal Year: 2013..novel therapies for the neurobehavioral symptoms associated with chronic hyperphenylalaninemia in phenylketonuria (PKU), one of the most common inborn errors of metabolism detected through newborn screening...
- Phase 2 Study of Glycomacropeptide vs. Amino Acid Diet for the Management of PKUDenise M Ney; Fiscal Year: 2013DESCRIPTION (provided by applicant): Individuals with PKU lack the enzyme phenylalanine hydroxylase that is needed to metabolize the essential amino acid phenylalanine (phe)...
- Mothers' Experience of Breastfeeding Infants with Phenylketonuria (PKU)SANDRA ANN BANTA WRIGHT; Fiscal Year: 2010..this proposed study is to understand how mothers manage breastfeeding infants with the disorder of phenylketonuria (PKU). PKU is an inborn error of metabolism disorder...
- A Policy-Oriented History of Newborn Screening for PKUDiane Paul; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): Phenylketonuria (PKU) has played a prominent role in the development of modern genetic medicine...
- AROMATIC AMINO ACID HYDROXYLASE GENES AND SCHIZOPHRENIAHELEN CHAO; Fiscal Year: 2000Genetic analysis of phenylalanine hydroxylase (PAH) in psychiatric patients and control subjects has shown that a mutation in the cofactor binding domain of the PAH enzyme is identified in patients only among those with the diagnosis of ..
- Intravenous non-viral gene therapy for phenylketonuria (PKU)Cary Harding; Fiscal Year: 2006..To this end, we will evaluate a novel intravenous hydrodynamic DNA transfer method to express the enzyme phenylalanine hydroxylase (PAH) in skeletal muscle of hyperphenylalaninemic Pahenu2 mice, a model of human PKU...
- Dietary Control of PKU with Glycomacropeptide from WheyDenise Ney; Fiscal Year: 2007Individuals with phenylketonuria (PKU) lack the enzyme phenylalanine hydroxylase needed to metabolize phenylalanine (phe) and show elevated blood phe (>20 mg phe/dL) with normal protein intake...
- AAV2/8 vector-mediated liver gene therapy for phenylketonuria (PKU)Cary Harding; Fiscal Year: 2009..this project is to develop a safe, effective liver- directed gene transfer technique for IEM by treating phenylalanine hydroxylase (PAH)-deficient Pahenu2 mice, a model of human phenylketonuria (PKU)...
- Phenylalanine Hydroxylase Deficiency: Response to BH4Reuben Matalon; Fiscal Year: 2002Phenylketonuria (PKU), due to phenylalanine hydroxylase (PAH) deficiency, is treated by dietary restriction of phenylalanine (Phe)...
- DOES PKU PROTECT AGAINST CANCER?Neil Sidell; Fiscal Year: 2003The disease phenylketonuria (PKU) is caused by mutations in the gene coding for phenylalanine hydroxylase (PAH) which results in hyperphenylalaninemia and elevated levels of abnormal phenylalanine metabolites...
- Stem Cell-Mediated Liver Repopulation for Murine PKUCary Harding; Fiscal Year: 2006..Wild type murine HSC will be transplanted into phenylalanine hydroxylase (PAH) deficient Pahenu2 mice, a model of human PKU, under the necessary proliferative and growth ..
- Nitric Oxide in Pulmonary HypertensionSerpil C Erzurum; Fiscal Year: 2013..Overall our goals are to define the pathophysiology of the abnormal vascular growth in PAH, and in so doing, apply the knowledge to improve the care of patients. ..
- National PKU Alliance 2014 &2016 Conference - Scientific ExchangeCHRISTINE SCHLEGEL BROWN; Fiscal Year: 2013DESCRIPTION (provided by applicant): This application is to support the National PKU Alliance's third and fourth national conference and focusing on the day long Scientific Exchange...
- Smooth Muscle Cell Protein Serotonylation and Pulmonary HypertensionBARRY FANBURG; Fiscal Year: 2013..We hope to better define any role of SERT, TGase activity and protein serotonylation in the development of PH and to consider possible new interventional strategies through these pathways that might be used for treating this disease. ..
- Right Ventricular-Pulmonary Vascular Interactions in Pulmonary HypertensionNaomi C Chesler; Fiscal Year: 2013..1 ..
- Modulating BMPRII Signaling in Pulmonary Arterial HypertensionEDDA FRAUKE SPIEKERKOETTER; Fiscal Year: 2013..The opportunity to modulate levels of relevant microRNAs and to identify a FDA approved drug that could arrest the progression or reverse PH by restoring normal BMP signaling would be a major breakthrough. ..
- Fibroblasts and Mononuclear Fibrogenic Cells Drive Right Ventricular Pulmonary ArKurt R Stenmark; Fiscal Year: 2013..Collectively, work by this interdisciplinary group will provide insight into abnormalities of RV-pulmonary arterial interactions in the setting of severe pulmonary hypertension and will lay the groundwork for potential new therapies. ..
- mTOR coordinates cell metabolism, growth and survival in pulmonary hypertensionElena Goncharova; Fiscal Year: 2013..abstract_text> ..
- Stanford Career Development Program in Omics of Lung DiseasesMichael P Snyder; Fiscal Year: 2013....
- Collagen Accumulation &Mechanical Mechanisms in Pulmonary HypertensionNaomi C Chesler; Fiscal Year: 2013....
- An inhaled PDGF receptor inhibitor for the treatment of pulmonary arterial hyperLawrence S Zisman; Fiscal Year: 2013..At the conclusion of this project, the inhaled formulation of PK10453 will have been identified for pivotal IND enabling studies. ..
- Genotypic and functional properties of HIV-1 Nef clinical isolates in PAH-HIVPriscilla Y Hsue; Fiscal Year: 2013..Our research tem, with a combination of basic and clinician scientists is well poised to address how the nef viral protein and immune dysregulation are contributing factors to this lung complication of HIV. ..
- Hormonal, Metabolic and Signaling Interactions in PAHJames E Loyd; Fiscal Year: 2013..This novel program builds directly on recent discoveries of PAH mechanisms to develop therapeutics targeted to interdict those biologic pathways. ..
- Role of MicroRNAs 424 and 503 in Pulmonary Arterial HypertensionHyung Joon Chun; Fiscal Year: 2013....
- Genetic Analysis of Murine Chronic Hypoxia-Induced Pulmonary HypertensionWilliam C Nichols; Fiscal Year: 2013..A better understanding of the genetics of right heart dysfunction in these diseases will likely enable new therapies to prevent and/or to treat right heart failure, resulting in reduced morbidity and mortality. ..
- A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary DysplasiaPrakash Jagtap; Fiscal Year: 2013..The heart will undergo morphometric analysis for evidence of PAH (as shown by right ventricular (RV) hypertrophy). ..
- Asthma Increases Vaso-occlusion in Sickle Cell DiseaseKirkwood A Pritchard; Fiscal Year: 2013..If we are correct, then our drug therapies should improve blood vessel function and decrease airway resistance in SCD mice with experimental asthma. ..
- Pulmonary Vascular-Right Ventricular Axis Research ProgramWai Hong Wilson Tang; Fiscal Year: 2013..We test this hypothesis PAEC derived from patients'lungs, explanted human hearts, and in a mechanistic longitudinal study of ?AR blockade in PAH patients. ..
- Molecular Mechanisms of Pulmonary Hypertension in COPDFerhaan Ahmad; Fiscal Year: 2010..This project will analyze the way genes are expressed in their lungs, to determine how this disease develops and to identify ways of curing it. (End of Abstract) ..
- IXth International Pulmonary Hypertension Conference: Scientific SessionsIvan M Robbins; Fiscal Year: 2010..It should also serve to foster collaboration between basic scientists and clinicians to stimulate more translational research. ..
- Prenatal Exposures & Procarcinogenic MutationsManuela Orjuela; Fiscal Year: 2007..Thus, the ultimate goal of this research is to contribute to the prevention of future childhood ALL. ..
- Validation of PAH Biomarkers for Quantifying Cancer RiskJunfeng Zhang; Fiscal Year: 2003..Statistical methods to be used will include descriptive analyses, scatter plots, correlation analyses, paired comparisons, and linear mixed models. In the mixed models, age, sex, height, weight, and body mass index will be adjusted for. ..
- Nitric Oxide in Pulmonary HypertensionSerpil Erzurum; Fiscal Year: 2009..Our goals in this competitive renewal are to define the pathophysiology of the abnormal vascular growth, and in so doing, apply the knowledge to improve the care of patients. ..