Gene Symbol: PHACTR3
Description: phosphatase and actin regulator 3
Alias: C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3, protein phosphatase 1, regulatory subunit 123, scaffold-associated PP1-inhibiting protein
Species: human
Products:     PHACTR3

Top Publications

  1. Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, et al. Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure. J Biol Chem. 2003;278:45611-9 pubmed
    ..Furthermore, it inhibited PP1 activity in vitro. We therefore named it scapinin (scaffold-associated PP1 inhibiting protein)...
  2. Allen P, Greenfield A, Svenningsson P, Haspeslagh D, Greengard P. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Proc Natl Acad Sci U S A. 2004;101:7187-92 pubmed
    ..The current findings present a mechanism by which PP1 may be directed toward neuronal substrates associated with the actin cytoskeleton. ..
  3. Worch S, Fiedler E, Hansmann I, Schlote D. Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human. Cytogenet Genome Res. 2006;115:23-9 pubmed
    b>Scapinin has been found to bind to cytoplasmic actin and is also a putative regulatory subunit of protein phosphatase-1 (PP1)...
  4. Papadia C, Louwagie J, Del Rio P, Grooteclaes M, Coruzzi A, Montana C, et al. FOXE1 and SYNE1 genes hypermethylation panel as promising biomarker in colitis-associated colorectal neoplasia. Inflamm Bowel Dis. 2014;20:271-7 pubmed publisher
    ..Methylation markers may be able to do this. SYNE1, FOXE1, NDRG4, and PHACTR3 genes were screened using methylation-specific PCR that permit the methylation status of the genes to be ..
  5. Liang L, Zeng J, Qin X, Chen J, Luo D, Chen G. Distinguishable Prognostic Signatures of Left- and Right-Sided Colon Cancer: a Study Based on Sequencing Data. Cell Physiol Biochem. 2018;48:475-490 pubmed publisher
    ..Using univariate COX regression analysis, five genes (PHACTR3, CKMT2, CYP2W1, ERFE, HOXC4) were related to overall survival in left-sided, and eight distinguishable genes (..
  6. Schneider E, El Hajj N, Müller F, Navarro B, Haaf T. Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers. Cytogenet Genome Res. 2015;146:19-27 pubmed publisher
    ..DMRs and published data sets, our methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
  7. Bourgier C, Kerns S, Gourgou S, Lemanski C, Gutowski M, Fenoglietto P, et al. Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial. Ann Oncol. 2016;27:474-80 pubmed publisher
    ..2 × 10(-9)) and rs1182532 (P = 3.6 × 10(-8)); both located within the PHACTR3 gene on chromosome 20q13.33...
  8. Sagara J, Arata T, Taniguchi S. Scapinin, the protein phosphatase 1 binding protein, enhances cell spreading and motility by interacting with the actin cytoskeleton. PLoS ONE. 2009;4:e4247 pubmed publisher
    b>Scapinin, also named phactr3, is an actin and protein phosphatase 1 (PP1) binding protein, which is expressed in the adult brain and some tumor cells. At present, the role(s) of scapinin in the brain and tumors are poorly understood...
  9. Bosch L, Oort F, Neerincx M, Khalid de Bakker C, Terhaar Sive Droste J, Melotte V, et al. DNA methylation of phosphatase and actin regulator 3 detects colorectal cancer in stool and complements FIT. Cancer Prev Res (Phila). 2012;5:464-72 pubmed publisher
    ..b>Phosphatase and Actin Regulator 3 (PHACTR3) was identified as a novel hypermethylated gene showing more than 70-fold increased DNA ..

More Information


  1. Bankovic J, Stojsic J, Jovanovic D, Andjelkovic T, Milinkovic V, Ruzdijic S, et al. Identification of genes associated with non-small-cell lung cancer promotion and progression. Lung Cancer. 2010;67:151-9 pubmed publisher
    ..homology search in GenBank database which revealed the following genes: TSPAN14, CDH12, RDH10, CYP4Z1, KIR, E2F4, PHACTR3, PHF20, PRAME family member and SLC2A13...
  2. Farghaian H, Chen Y, Fu A, Fu A, Ip J, Ip N, et al. Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm. J Biol Chem. 2011;286:19724-34 pubmed publisher
    b>Scapinin is an actin- and PP1-binding protein that is exclusively expressed in the brain; however, its function in neurons has not been investigated...
  3. Wang J, Bansal A, Martin M, Germer S, Benayed R, Essioux L, et al. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. Pharmacogenomics J. 2013;13:235-41 pubmed publisher
    ..This study suggests that it is unlikely that a major genetic determinant of response exists, and it illustrates the complexity of performing genome-wide association scans in clinical trials. ..