Gene Symbol: PGC
Description: progastricsin
Alias: PEPC, PGII, gastricsin, pepsin C, pepsinogen C, pepsinogen group II, preprogastricsin
Species: human
Products:     PGC

Top Publications

  1. Broutet N, Plebani M, Sakarovitch C, Sipponen P, Megraud F. Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics. Br J Cancer. 2003;88:1239-47 pubmed
    ..The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG)..
  2. Di Mario F, Moussa A, Cavallaro L, Caruana P, Merli R, Bertolini S, et al. Clinical usefulness of serum pepsinogen II in the management of Helicobacter pylori infection. Digestion. 2004;70:167-72 pubmed
    ..sPGII levels may be used as a reliable marker of H. pylori infection in the initial diagnosis as well as to evaluate H. pylori eradication and subsequent changes in gastric inflammation. ..
  3. Shiotani A, Iishi H, Uedo N, Kumamoto M, Nakae Y, Ishiguro S, et al. Histologic and serum risk markers for noncardia early gastric cancer. Int J Cancer. 2005;115:463-9 pubmed
    ..Annual endoscopic follow-up is warranted for patients with IM found at the greater curvature of the corpus. ..
  4. Pimanov S, Makarenko E, Voropaeva A, Matveenko M, Voropaev E. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. J Gastroenterol Hepatol. 2008;23:1666-71 pubmed
    ..pylori score reduced. Other morphological changes were statistically non-significant. Patients with duodenal ulcer after successful eradication have improvement of morphological and functional characteristics of gastric mucosa. ..
  5. He C, Sun L, Gong Y, Xu Q, Dong N, Yuan Y. Serum pepsinogen II: a neglected but useful biomarker to differentiate between diseased and normal stomachs. J Gastroenterol Hepatol. 2011;26:1039-46 pubmed publisher
    ..Furthermore, Chinese patients with sPGII greater than 10.25 microg/L are at greater risk of various H. pylori-related gastropathies, and are therefore prior candidates for gastro-protection therapy. ..
  6. Li D, Zhang J, Xi Y, Zhang L, Li W, Cui J, et al. Mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein induce cell differentiation in gastric cancer. BMC Cancer. 2015;15:637 pubmed publisher
    ..MAWD/MAWBP and clinicopathologic characteristics of GC tissues and examined the expression of E-cadherin and pepsinogen C (PGC)-used as gastric mucosa differentiation markers-in MAWD/MAWBP-overexpressing GC cells and xenografts...
  7. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..biogenesis as a compensatory adaptation to the energetic deficits in mitochondrial diseases are described (PGC- 1, Sirtuins, AMPK)...
  8. Ogias D, Rattes I, Hosoya L, Zulian J, Yan C, Gama P. Neonatal- maternal separation primes zymogenic cells in the rat gastric mucosa through glucocorticoid receptor activity. Sci Rep. 2018;8:9823 pubmed publisher
    ..In the gastric mucosa, Mist1 (encoded by Bhlha15 gene) and moesin organize the secretory apparatus for pepsinogen C in zymogenic cells...
  9. Jakic B, Carlsson M, Buszko M, Cappellano G, Ploner C, Onestingel E, et al. The Effects of Endurance Exercise and Diet on Atherosclerosis in Young and Aged ApoE-/- and Wild-Type Mice. Gerontology. 2019;65:45-56 pubmed publisher
    ..Moreover, gene expression analysis showed that exercise seems to affect the AMPK signaling pathway. In particular, PGC-1α1 mRNA was induced in aged WT mice, whereas it was reduced in young ApoE-/- mice...

More Information

Publications145 found, 100 shown here

  1. Singh A, Pandey S, Saha G, Gattupalli N. Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats. Exp Gerontol. 2015;66:1-9 pubmed publisher
    ..hepatic mitochondrial content (41%), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) mRNA (25%) and mitochondrial Superoxide Dismutase (Mit-SOD) activity (94%) were also observed in EcN-5 ..
  2. Xu Y, Ruan S, Lin J, Zhang Z. Yishen Jiangzhuo Granules affect tubulointerstitial fibrosis via a mitochondrion-mediated apoptotic pathway. Chin J Integr Med. 2015;21:928-37 pubmed publisher
    ..The expressions of Bax, Bcl-2, peroxisome proliferator-activated receptor γ coactivator- 1α (PGC-1α), mitochondrial transcription factor A (Tfam), mitogen-activated protein kinases (MAPK) phosphorylation were ..
  3. Shi H, Xu C, Liu M, Wang B, Liu W, Chen D, et al. Resveratrol Improves the Energy Sensing and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK-SIRT1-PGC-1α Network. Front Physiol. 2018;9:1258 pubmed publisher
    ..and p-AMPKα/t-AMPKα ratio as well as the transcriptions of AMPKα1, AMPKα2, SIRT1, PPARγ coactivator-1α (PGC-1α), phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase (FBPase), glucose-6-phosphatase, carnitine ..
  4. Ghosh S, Taylor J, Mendoza T, Dang T, Burk D, Yu Y, et al. Siah2 modulates sex-dependent metabolic and inflammatory responses in adipose tissue to a high-fat diet challenge. Biol Sex Differ. 2019;10:19 pubmed publisher
    ..expression of markers of inflammation (F4/80, Ccl2) and thermogenic genes (Pgc1alpha, Dio2, Ucp-1) and proteins (PGC-1α, UCP-1) in females...
  5. Rahman M, Kwon H, Kim M, Go H, Oak M, Kim D. Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. Biomed Pharmacother. 2017;92:606-614 pubmed publisher
    ..biogenesis related proteins such as peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1 α), nuclear respiratory factor (NRFs) and mitochondrial transcription factor-A were up-regulated skeletal and ..
  6. Wang R, Sun Q, Xia F, Chen Z, Wu J, Zhang Y, et al. Methane rescues retinal ganglion cells and limits retinal mitochondrial dysfunction following optic nerve crush. Exp Eye Res. 2017;159:49-57 pubmed publisher
    ..function was assessed by the mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator-1? (PGC-1?), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM), the mitochondrial DNA (..
  7. Waldman M, Nudelman V, Shainberg A, Abraham N, Kornwoski R, Aravot D, et al. PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis. Exp Cell Res. 2018;373:112-118 pubmed publisher
    ..PARP-1 inhibition led to increased SIRT1 and Peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α) levels, attenuating oxidative stress, inflammation and fibrosis...
  8. Raefsky S, Mattson M. Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance. Free Radic Biol Med. 2017;102:203-216 pubmed publisher
    ..g., Ca2+, CREB, PGC-1α, NF-κB) that stimulate mitochondrial biogenesis and cellular stress resistance...
  9. Whitaker E, Bissonnette B, Miller A, Koppert T, Tobias J, Pierson C, et al. A novel, clinically relevant use of a piglet model to study the effects of anesthetics on the developing brain. Clin Transl Med. 2016;5:2 pubmed publisher
    ..National Institutes of Health, Bethesda, MD, USA) was used to count absolute number of progenitor glial cells (PGC) and number of PGCs per cluster...
  10. Melis M, Diaz G, Kleiner D, Zamboni F, Kabat J, Lai J, et al. Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus-associated hepatocellular carcinoma. J Transl Med. 2014;12:230 pubmed publisher
    ..of pathways involved in the activation of PXR/RXR and PPARα/RXRα nuclear receptors, comprising PGC-1α and FOXO1, two key regulators critically involved not only in the metabolic functions of the liver but also ..
  11. Marineli R, Moura C, Moraes Ã, Lenquiste S, Lollo P, Morato P, et al. Chia (Salvia hispanica L.) enhances HSP, PGC-1α expressions and improves glucose tolerance in diet-induced obese rats. Nutrition. 2015;31:740-8 pubmed publisher
    ..seed and short treatment with chia oil restored peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) expression...
  12. Shah M, Brownlee M. Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circ Res. 2016;118:1808-29 pubmed publisher
    ..ROS and poly(ADP-ribose) polymerase also reduce sirtuin, PGC-1?, and AMP-activated protein kinase activity...
  13. Du X, Shen T, Wang H, Qin X, Xing D, Ye Q, et al. Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver. J Dairy Sci. 2018;101:9544-9558 pubmed publisher
    ..COX IV), voltage dependent anion channel 1 (VDAC1), peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) and nuclear respiratory factor 1 (NRF1), and adenosine triphosphate (ATP) content were all markedly increased ..
  14. Mizutani T, Ishikane S, Kawabe S, Umezawa A, Miyamoto K. Transcriptional regulation of genes related to progesterone production. Endocr J. 2015;62:757-63 pubmed publisher
    ..various NR5A-interacting proteins including peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), nuclear receptor subfamily 0, group B, member 1 (DAX-1), and CCAAT/enhancer-binding proteins (C/EBP) are ..
  15. Zhang X, Lv Q, Jia S, Chen Y, Sun C, Li X, et al. Effects of flavonoid-rich Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit extract on regulating glucose and lipid metabolism in diabetic KK-A(y) mice. Food Funct. 2016;7:3130-40 pubmed publisher
    ..through the inhibition of hepatic gluconeogenesis, which was supported by the reduced PPARγ coactivator 1-alpha (PGC-1α) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA expressions in the liver of KK-A(y) mice and by the ..
  16. Chen L, Chien Y, Liang C, Chan C, Fan M, Huang H. Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat. Food Nutr Res. 2017;61:1347480 pubmed publisher
    ..HDL: High-density lipoprotein; HED: high-energy diet; LDL: Low-density lipoprotein; MFP: Mesenteric fat pad; PGC-1α: Activates PPAR-γ coactivator-1; PPAR-γ: Peroxisome proliferator-activated receptor-γ; PRDM-16: PR ..
  17. Zhang M, Tang J, Li Y, Xie Y, Shan H, Chen M, et al. Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1?/SIRT3 pathway involved. Chem Biol Interact. 2017;277:168-175 pubmed publisher
    ..Furthermore, curcumin significantly increased the mRNA and protein expression of PGC-1? and SIRT3 in the skeletal muscle tissues of COPD rats...
  18. Katic M, Kennedy A, Leykin I, Norris A, McGettrick A, Gesta S, et al. Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell. 2007;6:827-39 pubmed
    ..synthase activity, increased expression of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) and PGC-1beta, and an increase in mitochondrial DNA in WAT of FIRKO mice...
  19. Lu Y, Li S, Wu H, Bian Z, Xu J, Gu C, et al. Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells. Int J Mol Med. 2015;36:1223-32 pubmed publisher
    ..led to an increase in the mRNA expression of peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) and mitochondrial transcription factor A (Tfam), and in the protein expression of PGC-1α, parkin and ..
  20. Waldman M, Cohen K, Yadin D, Nudelman V, Gorfil D, Laniado Schwartzman M, et al. Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving 'SIRT1 and PGC-1α'. Cardiovasc Diabetol. 2018;17:111 pubmed publisher
    ..heart; this effect involves antioxidant defenses and is mediated by SIRT1 and the transcriptional coactivator PGC-1α (Peroxisome proliferator-activated receptor-γ coactivator)...
  21. Liu Q, Krishnasamy Y, Rehman H, Lemasters J, Schnellmann R, Zhong Z. Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats. PLoS ONE. 2015;10:e0140906 pubmed publisher
    ..Renal PGC-1α, the major regulator of MB, decreased 57% with lower mRNA and increased acetylation, indicating inhibited ..
  22. Xu X, Zheng N, Chen Z, Huang W, Liang T, Kuang H. Puerarin, isolated from Pueraria lobata (Willd.), protects against diabetic nephropathy by attenuating oxidative stress. Gene. 2016;591:411-6 pubmed publisher protein O1 (FOXO1) and alpha subunit of peroxisome proliferators-activated receptor-gamma coactivator-1 (PGC-1?) expressions were significantly up-regulated at protein level by PR administration in renal cortex...
  23. Fernández Galilea M, Pérez Matute P, Prieto Hontoria P, Houssier M, Burrell M, Langin D, et al. α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects. Biochim Biophys Acta. 2015;1851:273-81 pubmed publisher
    ..The involvement of the Sirtuin1/Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (SIRT1/PGC-1α) pathway was also evaluated...
  24. Suliman H, Kraft B, Bartz R, Chen L, Welty Wolf K, Piantadosi C. Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2017;313:L699-L709 pubmed publisher
    ..regulators nuclear respiratory factor-1 (NRF-1) and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and increases in light chain 3B protein (LC3-I)/LC3II ratios...
  25. Gehrke N, Wörns M, Huber Y, Hess M, Straub B, Hövelmeyer N, et al. Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors. J Hepatol. 2016;65:1188-1197 pubmed publisher
    ..Based on in vivo and in vitro studies we identified the transcription factors PPAR?, PPAR? and PGC-1? as critical regulators of hepatic metabolism and inflammation downstream of Bcl-3...
  26. Zhou X, Chen M, Zeng X, Yang J, Deng H, Yi L, et al. Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells. Cell Death Dis. 2014;5:e1576 pubmed publisher
    ..protein kinase (p-AMPK), peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and Sirt3, as well as estrogen-related receptor-α (ERRα)-dependent Sirt3 mRNA transcription, which ..
  27. Singh V, Jain M, Misra A, Khanna V, Prakash P, Malasoni R, et al. Curcuma oil ameliorates insulin resistance & associated thrombotic complications in hamster & rat. Indian J Med Res. 2015;141:823-32 pubmed publisher
    ..regulatory element binding protein 1c (SREBP-1c), peroxisome proliferator-activated receptor-gamma co-activator 1 (PGC-1)α and PGC-1β genes known to be involved in lipid and glucose metabolism...
  28. Diaz Gerevini G, Repossi G, Dain A, Tarres M, Das U, Eynard A. Beneficial action of resveratrol: How and why?. Nutrition. 2016;32:174-8 pubmed publisher
    ..This increases the cytosolic cAMP that activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway, which in turn facilitates increased oxidation of fatty acids, mitochondrial biogenesis, ..
  29. Mutlur Krishnamoorthy R, Carani Venkatraman A. Polyphenols activate energy sensing network in insulin resistant models. Chem Biol Interact. 2017;275:95-107 pubmed publisher
    ..dependent type III deacetylase (SIRT1) and peroxisome proliferator-activated receptor-? coactivator-1? (PGC-1?) which is disrupted in T2D...
  30. Martínez Redondo V, Jannig P, Correia J, Ferreira D, Cervenka I, Lindvall J, et al. Peroxisome Proliferator-activated Receptor ? Coactivator-1 ? Isoforms Selectively Regulate Multiple Splicing Events on Target Genes. J Biol Chem. 2016;291:15169-84 pubmed publisher
    ..Peroxisome proliferator-activated receptor ? coactivator-1 ? (PGC-1?) coactivators are not only among the genes differentially induced by distinct training methods, but they also ..
  31. Shirane K, Kurimoto K, Yabuta Y, Yamaji M, Satoh J, Ito S, et al. Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells. Dev Cell. 2016;39:87-103 pubmed publisher
    ..Here, we uncover regulatory principles for DNA methylation reprogramming during in vitro PGC specification, in which mouse embryonic stem cells (ESCs) are induced into epiblast-like cells (EpiLCs) and then ..
  32. Lai T, Lin C, Wu Y, Wu C. Tissue transglutaminase (TG2) and mitochondrial function and dysfunction. Front Biosci (Landmark Ed). 2017;22:1114-1137 pubmed
    ..the assembly of respiratory chain complexes but can also modulate the transcription of critical genes including PGC-1alpha and cytochrome C that are important for function and biogenesis of mitochondria...
  33. Ferrazoli E, de Souza H, Nascimento I, Oliveira Giacomelli Ã, Schwindt T, Britto L, et al. Brilliant Blue G, But Not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease. Cell Transplant. 2017;26:669-677 pubmed publisher
    ..On the other hand, peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) is involved in energy metabolism and mitochondrial biogenesis...
  34. Kumazoe M, Takai M, Hiroi S, Takeuchi C, Kadomatsu M, Nojiri T, et al. The FOXO3/PGC-1? signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. J Biol Chem. 2017;292:10813-10823 pubmed publisher
    ..kinase B1 (LKB1)/AMP-activated protein kinase/peroxisome proliferator-activated receptor-? co-activator-1? (PGC-1?)/pyruvate dehydrogenase-A1 pathway is essential for CD44 expression and CSC properties...
  35. Inata Y, Kikuchi S, Samraj R, Hake P, O Connor M, Ledford J, et al. Autophagy and mitochondrial biogenesis impairment contributes to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway. FASEB J. 2017;: pubmed publisher
    ..controls mitochondrial biogenesis by activation of peroxisome proliferator-activated receptor-? coactivator-? (PGC-1?) and disposal of defective organelles by autophagy...
  36. Ashwood C, Lin C, Thaysen Andersen M, Packer N. Discrimination of Isomers of Released N- and O-Glycans Using Diagnostic Product Ions in Negative Ion PGC-LC-ESI-MS/MS. J Am Soc Mass Spectrom. 2018;29:1194-1209 pubmed publisher
    ..This platform-independent workflow can potentially be extended to automate the characterization and quantitation of other challenging glycan isomers. Graphical Abstract ᅟ. ..
  37. Eisele P, Furrer R, Beer M, Handschin C. The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo. Biochem Biophys Res Commun. 2015;464:692-7 pubmed publisher
    The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is abundantly expressed in trained muscles and regulates muscle adaptation to endurance exercise...
  38. Lee J, Seo W, Han H, Oh K, Lee Y, Kim D, et al. Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis. Diabetes. 2016;65:62-73 pubmed publisher
    The role of a glucagon/cAMP-dependent protein kinase-inducible coactivator PGC-1α signaling pathway is well characterized in hepatic gluconeogenesis...
  39. Toda K, Takeda S, Hitoe S, Nakamura S, Matsuda H, Shimoda H. Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism. J Nat Med. 2016;70:163-72 pubmed publisher
    ..The expression of peroxisome proliferator-activated receptor γ coactivator (PGC)-1α was enhanced in pC2C12 cells. In addition, KPE enhanced the production of ATP and mitochondrial biogenesis...
  40. Chen S, Su X, Gao J, Han H, Chen Z, Lin S. [Suppression of Kiss-1 gene inhibits HCT116 human colorectal carcinoma cell migration in vitro via nuclear factor-κB signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:1643-8 pubmed
    ..A recombinant lentiviral vector of Kiss-1 gene pGC-LV-Kiss-1-EGFP or the empty vector was transfected in HCT116 cells...
  41. Chandra A, Sharma A, Calingasan N, White J, Shurubor Y, Yang X, et al. Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease. Hum Mol Genet. 2016;25:2269-2282 pubmed
    ..Recently, we showed that the administration of bezafibrate, a pan-PPAR agonist, increases the expression of PGC-1α and mitochondrial biogenesis, and improves phenotype and survival in R6/2 transgenic mouse model of HD...
  42. Szalárdy L, Molnár M, Török R, Zadori D, Kovacs G, Vecsei L, et al. Lack of age-related clinical progression in PGC-1α-deficient mice - implications for mitochondrial encephalopathies. Behav Brain Res. 2016;313:272-281 pubmed publisher
    Impaired peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) function has been demonstrated in several neurodegenerative diseases, and murine whole-body knockouts of PGC-1α have been considered as models for ..
  43. Chamoto K, Chowdhury P, Kumar A, Sonomura K, Matsuda F, Fagarasan S, et al. Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity. Proc Natl Acad Sci U S A. 2017;114:E761-E770 pubmed publisher
    ..kinase (AMPK) but also an increment of their downstream transcription factors such as PPAR-gamma coactivator 1α (PGC-1α) and T-bet...
  44. Zhang Y, Ma J, Li H, Lv J, Wei R, Cong Y, et al. bFGF signaling-mediated reprogramming of porcine primordial germ cells. Cell Tissue Res. 2016;364:429-41 pubmed publisher
    ..To explore molecular events involved in porcine PGC reprogramming, transcriptome data of porcine EGCs and fetal fibroblasts (FFs) were assembled and 1169 ..
  45. Oropeza D, Jouvet N, Bouyakdan K, Perron G, Ringuette L, Philipson L, et al. PGC-1 coactivators in ?-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids. Mol Metab. 2015;4:811-22 pubmed publisher
    Peroxisome proliferator-activated receptor ? coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important for nutrient metabolism...
  46. Choi J, Yun J. Chrysin induces brown fat-like phenotype and enhances lipid metabolism in 3T3-L1 adipocytes. Nutrition. 2016;32:1002-10 pubmed publisher
    ..carnitine palmitoyltransferase 1, acyl-coenzyme A oxidase 1, peroxisome proliferator-activated receptor-1 alpha (PGC-1?), and uncoupling protein 1 (UCP-1), suggesting its possible role in augmentation of lipolysis, fat oxidation, ..
  47. Slaidina M, Lehmann R. Quantitative Differences in a Single Maternal Factor Determine Survival Probabilities among Drosophila Germ Cells. Curr Biol. 2017;27:291-297 pubmed publisher germ plasm inheritance, such that higher germ plasm inheritance correlates with higher primordial germ cell (PGC) survival probability...
  48. Sasado T, Kondoh H, Furutani Seiki M, Naruse K. Mutation in cpsf6/CFIm68 (Cleavage and Polyadenylation Specificity Factor Subunit 6) causes short 3'UTRs and disturbs gene expression in developing embryos, as revealed by an analysis of primordial germ cell migration using the medaka mutant naruto. PLoS ONE. 2017;12:e0172467 pubmed publisher
    Our previous studies analyzing medaka mutants defective in primordial germ cell (PGC) migration identified cxcr4b and cxcr7, which are both receptors of the chemokine sdf1/cxcl12, as key regulators of PGC migration...
  49. Xu Y, Zhao C, Sun X, Liu Z, Zhang J. MicroRNA-761 regulates mitochondrial biogenesis in mouse skeletal muscle in response to exercise. Biochem Biophys Res Commun. 2015;467:103-8 pubmed publisher
    ..myocytes by targeting the 3'-UTR of peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1 (PGC-1α). Overexpression of miR-761 was capable of inhibiting the protein expression levels of PGC-1α...
  50. Yan M, Audet Walsh E, Manteghi S, Dufour C, WALKER B, Baba M, et al. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1?/ERR?. Genes Dev. 2016;30:1034-46 pubmed publisher
    ..key transcriptional regulators of cellular metabolism, proliferator-activated receptor ? (PPAR?) coactivator-1? (PGC-1?) and estrogen-related receptor ? (ERR?)...
  51. Cheng L, Hung K, Lee T, Huang C, Chiu W, Lo J, et al. Mitochondrial co-chaperone protein Tid1 is required for energy homeostasis during skeletal myogenesis. Stem Cell Res Ther. 2016;7:185 pubmed
    ..The protein levels of ATP sensor (p-AMPK) and mitochondrial biogenesis protein (PGC-1?) were also significantly reduced in HSA-Tid1f/f mice...
  52. Xie X, Lin J, Li P, Xie J, Wang J, Lu J, et al. A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer. Oncotarget. 2017;8:81511-81519 pubmed publisher
    ..factors of postoperative hemorrhage (PH) following laparoscopy-assisted radical gastrectomy (LARG) with D2 lymphadenectomy for primary gastric cancer (PGC) and to use those risk factors to develop a scoring system for risk assessment.
  53. Pettersson Klein A, Izadi M, Ferreira D, Cervenka I, Correia J, Martínez Redondo V, et al. Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration. Mol Metab. 2018;9:28-42 pubmed publisher
    The peroxisome proliferator-activated receptor-γ coactivator-1α1 (PGC-1α1) regulates genes involved in energy metabolism...
  54. Kunst S, Wolloscheck T, Kelleher D, Wolfrum U, Sargsyan S, Iuvone P, et al. Pgc-1α and Nr4a1 Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina. Invest Ophthalmol Vis Sci. 2015;56:6084-94 pubmed publisher
    ..transcriptional regulators important for retinal physiology and/or pathology (Dbp, Egr-1, Fos, Nr1d1, Nr2e3, Nr4a1, Pgc-1α, Rorβ) for circadian regulation and dependence on melatonin signaling/MT1 receptors or dopamine signaling/..
  55. Tang L, Wang J, Xu T, Zhao Z, Zheng J, Ge R, et al. Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes. Toxicology. 2017;382:108-116 pubmed publisher
    ..interaction of IP3R-Grp75-VDAC and accumulated intracellular fatty acids by activating Rictor, thereby attenuating PGC-1? and Mfn2 expressions, then destroying mitochondria-associated endoplasmic reticulum membrane (MAM), which ..
  56. Stein M, Dütting S, Mougiakakos D, Bösl M, Fritsch K, Reimer D, et al. A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1. Cell Death Differ. 2017;24:1239-1252 pubmed publisher
    ..EFhd1 in EFhd1 transgenic mice beyond the pro B cell stage increased expression of the mitochondrial co-activator PGC-1? in primary pre B cells, but reduced mitochondrial ATP production at the pro to pre B cell transition in IL-7 ..
  57. Brandt N, Dethlefsen M, Bangsbo J, Pilegaard H. PGC-1? and exercise intensity dependent adaptations in mouse skeletal muscle. PLoS ONE. 2017;12:e0185993 pubmed publisher
    The aim of the present study was to examine the role of PGC-1? in intensity dependent exercise and exercise training-induced metabolic adaptations in mouse skeletal muscle...
  58. Petrov D, Luque M, Pedrós I, Ettcheto M, Abad S, Pallas M, et al. Evaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer's Disease. Mol Neurobiol. 2016;53:6183-6193 pubmed publisher
    ..In addition, protein levels of PPAR gamma coactivator-1? (PGC-1?), a molecule involved in mitochondrial biogenesis and energy homeostasis, were decreased in 9-month-old APPswe/..
  59. Tran N, Kissner M, Subramanyam D, Parchem R, Laird D, Blelloch R. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. Stem Cells. 2016;34:1985-91 pubmed publisher
    ..These findings uncover a miR-372/let-7 axis regulating human primordial germ cell (PGC) specification. Stem Cells 2016;34:1985-1991.
  60. Lee C, Huntley B, McCormick D, Ichiki T, Sangaralingham S, Lisy O, et al. Cenderitide: structural requirements for the creation of a novel dual particulate guanylyl cyclase receptor agonist with renal-enhancing in vivo and ex vivo actions. Eur Heart J Cardiovasc Pharmacother. 2016;2:98-105 pubmed publisher
    ..natriuretic peptide (NP) receptor chimeric peptide activator, which targets the particulate guanylyl cyclase B (pGC-B) receptor and pGC-A unlike native NPs...
  61. Imasawa T, Obre E, Bellance N, Lavie J, Imasawa T, Rigothier C, et al. High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy. FASEB J. 2017;31:294-307 pubmed publisher
    ..during cell differentiation that was characterized by peroxisome proliferator-activated receptor-? coactivator 1? (PGC-1?)-dependent stimulation of mitochondrial biogenesis and function, with concomitant reduction of the glycolytic ..
  62. Kang M, Liu X, Fu Y, Timothy Garvey W. Improved systemic metabolism and adipocyte biology in miR-150 knockout mice. Metabolism. 2018;83:139-148 pubmed publisher
    ..Expression of PGC-1α, another target gene of miR-150, was also increased together with upregulation of PPARα and glycerol kinase in ..
  63. Pinto Correia A, Pinto D, Pereira D, Rodrigues H, de Sousa J, Sousa H, et al. Overall survival in women with breast cancer: the influence of pepsinogen C gene polymorphism. DNA Cell Biol. 2008;27:333-6 pubmed publisher
    We aimed to study the role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients. The six polymorphic alleles were amplified using PCR...
  64. Ogasawara R, Fujita S, Hornberger T, Kitaoka Y, Makanae Y, Nakazato K, et al. The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep. 2016;6:31142 pubmed publisher
    ..synthesis, ribosome biogenesis, autophagy, and the expression of peroxisome proliferator gamma coactivator 1 alpha (PGC-1α). However, direct evidence to support the aforementioned relationships is lacking...
  65. Park G, Horie T, Kanayama T, Fukasawa K, Iezaki T, Onishi Y, et al. The transcriptional modulator Ifrd1 controls PGC-1? expression under short-term adrenergic stimulation in brown adipocytes. FEBS J. 2017;284:784-795 pubmed publisher
    ..These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex. ..
  66. Yu H, Zhang M, Ma Y, Lu J, Pan J, Pan P, et al. 5-ALA ameliorates hepatic steatosis through AMPK signaling pathway. J Mol Endocrinol. 2017;59:121-128 pubmed publisher
    ..Treated cells had a higher expression of lipolysis-related genes, including PGC-1α...
  67. Pae J, Cinalli R, Marzio A, Pagano M, Lehmann R. GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK. Dev Cell. 2017;42:130-142.e7 pubmed publisher
    ..We show that CRL3GCL promotes PGC fate by mediating degradation of Torso, a receptor tyrosine kinase (RTK) and major determinant of somatic cell fate...
  68. Oh D, Houston D. Role of maternal Xenopus syntabulin in germ plasm aggregation and primordial germ cell specification. Dev Biol. 2017;432:237-247 pubmed publisher
    ..oocytes results in defects in the aggregation and perinuclear transport of germ plasm and subsequently in reduced PGC numbers...
  69. Huang Y, Ye Z, Ma T, Li H, Zhao Y, Chen W, et al. Carbon monoxide (CO) modulates hydrogen peroxide (H2O2)-mediated cellular dysfunction by targeting mitochondria in rabbit lens epithelial cells. Exp Eye Res. 2018;169:68-78 pubmed publisher
    ..To evaluate mitochondrial biogenesis, several mitochondrial transcription factors (PGC-1α, NRF-1, and mtTFA) were detected by western blot analysis...
  70. Qin Q, Jin J, He F, Zheng Y, Li T, Zhang Y, et al. Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells. Biochem Biophys Res Commun. 2018;497:292-297 pubmed publisher
    ..Our findings demonstrated that Humanin treatment significantly increased the expression of PGC-1α and its downstream target genes NRF1 and TFAM in MIN6 β-cells...
  71. Xu X, Shi X, Chen Y, Zhou T, Wang J, Xu X, et al. HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter. Metabolism. 2018;85:126-138 pubmed publisher
    ..were performed to detect the binding of FXR to peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) promoter...
  72. Goto R, Saito T, Kawakami Y, Kitauchi T, Takagi M, Todo T, et al. Visualization of primordial germ cells in the fertilized pelagic eggs of the barfin flounder Verasper moseri. Int J Dev Biol. 2015;59:465-70 pubmed publisher
    ..The method developed here for labeling PGCs with gfp-nos3 mRNA will provide a means to study PGC development in the embryos of a wide range of marine fish species.
  73. Lee Y, Stevens D, Kang S, Jiang H, Lee Y, Ko H, et al. PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Rep. 2017;18:918-932 pubmed publisher
    ..role in dopamine cell loss through repression of proliferator-activated receptor gamma coactivator-1-alpha (PGC-1α) promoter activity...
  74. Tagami T, Miyahara D, Nakamura Y. Avian Primordial Germ Cells. Adv Exp Med Biol. 2017;1001:1-18 pubmed publisher
    ..The main factor involved in chicken PGC proliferation is fibroblast growth factor 2, which activates the signaling of MEK/ERK and thus promotes the cell ..
  75. Karnewar S, Neeli P, Panuganti D, Kotagiri S, Mallappa S, Jain N, et al. Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1115-1128 pubmed publisher
    ..Intriguingly, enhanced PGC-1? expression by SIRT3 via AMPK activation was responsible for increased hTERT expression and delayed endothelial ..
  76. Blitz I. Primordial Germ Cell Transplantation for CRISPR/Cas9-based Leapfrogging in Xenopus. J Vis Exp. 2018;: pubmed publisher
    ..Leapfrogging utilizes the transfer of primordial germ cells (PGCs) from efficiently-mutagenized donor embryos into PGC-ablated wildtype siblings...
  77. Mu Q, Yu W, Zheng S, Shi H, Li M, Sun J, et al. RIP140/PGC-1α axis involved in vitamin A-induced neural differentiation by increasing mitochondrial function. Artif Cells Nanomed Biotechnol. 2018;46:806-816 pubmed publisher
    ..regulate the morphology and function of mitochondria in its induction of neural differentiation through the RIP140/PGC-1α axis are unclear...
  78. Popov D, Lysenko E, Vepkhvadze T, Kurochkina N, Maknovskii P, Vinogradova O. Promoter-specific regulation of PPARGC1A gene expression in human skeletal muscle. J Mol Endocrinol. 2015;55:159-68 pubmed publisher
    The goal of this study was to identify unknown transcription start sites of the PPARGC1A (PGC-1α) gene in human skeletal muscle and investigate the promoter-specific regulation of PGC-1α gene expression in human skeletal muscle...
  79. Handschin C. Caloric restriction and exercise "mimetics'': Ready for prime time?. Pharmacol Res. 2016;103:158-66 pubmed publisher act on the common downstream effector peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in skeletal muscle...
  80. Lee S, Dorotea D, Jung I, Nakabayashi T, Miyata T, Ha H. TM5441, a plasminogen activator inhibitor-1 inhibitor, protects against high fat diet-induced non-alcoholic fatty liver disease. Oncotarget. 2017;8:89746-89760 pubmed publisher
    ..mitochondrial dysfunction, presented by enhanced p-Akt and p-GSK3?, reduced p-JNK signaling, along with p-AMPK and PGC-1? activation...
  81. Sanchez L, Freije J, Merino A, Vizoso F, Foltmann B, Lopez Otin C. Isolation and characterization of a pepsin C zymogen produced by human breast tissues. J Biol Chem. 1992;267:24725-31 pubmed
    ..The amino-terminal sequence of the purified breast proteinase was identical to that corresponding to gastric pepsinogen C. Additional data on cleavage specificity, pH optimum, and immunological properties supported the close ..
  82. Paton C, Vaughan R, Selen Alpergin E, Assadi Porter F, Dowd M. Dihydrosterculic acid from cottonseed oil suppresses desaturase activity and improves liver metabolomic profiles of high-fat-fed mice. Nutr Res. 2017;45:52-62 pubmed publisher
    ..PPAR? expression; however, in the liver, it was consistently elevated along with its transcriptional coactivator Pgc-1...
  83. Aoki T, Tomaki E, Morikawa J, Tsubota N, Watabe H. Purification of pepsinogens from human urine and electrophoretic analysis by caseogram print. Biochem Mol Biol Int. 1996;39:1147-56 pubmed
    ..Although the concentration of urinary PGC was very low, a trace amount was purified and visualized by electrophoresis...
  84. von Meyenn F, Berrens R, Andrews S, Santos F, Collier A, Krueger F, et al. Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification. Dev Cell. 2016;39:104-115 pubmed publisher
    Primordial germ cell (PGC) development is characterized by global epigenetic remodeling, which resets genomic potential and establishes an epigenetic ground state...
  85. Gleyzer N, Scarpulla R. Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction. J Biol Chem. 2016;291:25529-25541 pubmed
    b>PGC-1-related coactivator (PRC) has a dual function in growth-regulated mitochondrial biogenesis and as a sensor of metabolic stress...
  86. Liu A, Philip J, Vinnakota K, Van den Bergh F, Tabima D, HACKER T, et al. Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension. Physiol Rep. 2017;5: pubmed publisher
    ..The changes in mitochondrial biogenesis and function paralleled the expression levels of PGC-1α in RV Our results suggest that estrogen protects RV function by preserving mitochondrial content and ..
  87. Ruby M, Riedl I, Massart J, Åhlin M, Zierath J. Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2017;313:E483-E491 pubmed publisher
    ..At the transcriptional level, PKN2 knockdown increased expression of PGC-1α and SREBP-1c and their target genes...
  88. Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, et al. Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat. Cell Rep. 2017;20:641-654 pubmed publisher
    ..Mechanistically, SIRT6 interacts with and promotes phospho-ATF2 binding to the PGC-1? gene promoter to activate its expression...
  89. Han S, Wu M, Nam B, Park J, Yoo T, Kang S, et al. PGC-1α Protects from Notch-Induced Kidney Fibrosis Development. J Am Soc Nephrol. 2017;28:3312-3322 pubmed publisher
    ..Here, we show that, that expression of peroxisomal proliferation g-coactivator (PGC-1α) and fatty acid oxidation-related genes are lower in mice expressing active Notch1 in tubular epithelial ..
  90. Hong S, Lee J, Seo D, In Lee H, Ri Park D, Lee G, et al. Euphorbia factor L1 inhibits osteoclastogenesis by regulating cellular redox status and induces Fas-mediated apoptosis in osteoclast. Free Radic Biol Med. 2017;112:191-199 pubmed publisher
    ..EFL1 decreased the level of reactive oxygen species by scavenging them or activating Nrf2, and inhibited PGC-1? that regulates mitochondria biogenesis...
  91. Nakamura Y. Avian Biotechnology. Adv Exp Med Biol. 2017;1001:187-214 pubmed publisher
    ..Today, avian PGC transplantation combined with recent advanced manipulation techniques, including cell purification, ..
  92. Xiao Y, Wang J, Yan W, Zhou K, Cao Y, Cai W. p38? MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure. Cell Death Dis. 2017;8:e3110 pubmed publisher
    ..enzyme cholesterol 7-?-hydroxylase (CYP7A1) and peroxisome proliferator-activated receptor ? coactivator-1? (PGC-1?), which in turn activated the transcription of the CYP7A1...