PGBD5

Summary

Gene Symbol: PGBD5
Description: piggyBac transposable element derived 5
Alias: piggyBac transposable element-derived protein 5, piggyBac domain related protein 5, piggyBac transposase 5
Species: human
Products:     PGBD5

Top Publications

  1. Henssen A, Jiang E, Zhuang J, Pinello L, Socci N, Koche R, et al. Forward genetic screen of human transposase genomic rearrangements. BMC Genomics. 2016;17:548 pubmed publisher
    ..Here, we report the HPRT1 mutational spectrum induced by the human transposase PGBD5, including PGBD5-specific signal sequences (PSS) that serve as potential genomic rearrangement substrates...
  2. Giri A, Wu J, Ward R, Hartmann K, Park A, North K, et al. Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. PLoS ONE. 2015;10:e0141647 pubmed publisher
    ..36; p = 4.2x10-7) in the grade 0 vs 1-3 analyses and for SNPs around PGBD5 (rs740494, OR:2.17; p = 8.6x10-7) and SHC3 (rs2209875, OR:0.60; p = 9.3x10-7) in the grade 0 vs 2-3 analyses...
  3. Henssen A, Henaff E, Jiang E, Eisenberg A, Carson J, Villasante C, et al. Genomic DNA transposition induced by human PGBD5. elife. 2015;4: pubmed publisher
    ..In this study, we find that the protein encoded by human PGBD5, the most evolutionarily conserved transposable element-derived gene in vertebrates, can induce stereotypical cut-..
  4. Henssen A, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, et al. PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat Genet. 2017;49:1005-1014 pubmed publisher
    ..Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal ..
  5. Sarkar A, Sim C, Hong Y, Hogan J, Fraser M, Robertson H, et al. Molecular evolutionary analysis of the widespread piggyBac transposon family and related "domesticated" sequences. Mol Genet Genomics. 2003;270:173-80 pubmed
    ..Novel members of the piggyBac family may be useful in genetic engineering of many organisms. ..
  6. Henssen A, Reed C, Jiang E, Garcia H, von Stebut J, MacArthur I, et al. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med. 2017;9: pubmed publisher
    ..rhabdoid tumors, neuroblastoma, medulloblastoma, and Ewing sarcoma, express an active DNA transposase, PGBD5, that can promote site-specific genomic rearrangements in human cells...