Gene Symbol: PGBD3
Description: piggyBac transposable element derived 3
Alias: piggyBac transposable element-derived protein 3
Sarkar A, Sim C, Hong Y, Hogan J, Fraser M, Robertson H, et al
. Molecular evolutionary analysis of the widespread piggyBac transposon family and related "domesticated" sequences. Mol Genet Genomics. 2003;270:173-80 pubmed
..Novel members of the piggyBac family may be useful in genetic engineering of many organisms. ..
Newman J, Bailey A, Fan H, Pavelitz T, Weiner A. An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome. PLoS Genet. 2008;4:e1000031 pubmed publisher
..We now show that a domesticated PiggyBac-like transposon PGBD3, residing within intron 5 of the CSB gene, functions as an alternative 3' terminal exon...
Horibata K, Saijo M, Bay M, Lan L, Kuraoka I, Brooks P, et al
. Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex. Genes Cells. 2011;16:101-14 pubmed publisher
..These results suggested that reduced repair of a DNA topoisomerase I-DNA covalent complex because of truncated CSB proteins is involved in the pathogenesis of CS-B. ..
Bailey A, Gray L, Pavelitz T, Newman J, Horibata K, Tanaka K, et al
. The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells. DNA Repair (Amst). 2012;11:488-501 pubmed publisher
..Over 43Mya before marmosets diverged from humans, a piggyBac3 (PGBD3) transposable element integrated into intron 5 of the CSB gene...
Gray L, Fong K, Pavelitz T, Weiner A. Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans. PLoS Genet. 2012;8:e1002972 pubmed publisher
The CSB-PGBD3 fusion protein arose more than 43 million years ago when a 2.5-kb piggyBac 3 (PGBD3) transposon inserted into intron 5 of the Cockayne syndrome Group B (CSB) gene in the common ancestor of all higher primates...
Weiner A, Gray L. What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?. Mech Ageing Dev. 2013;134:225-33 pubmed publisher
The PGBD3 piggyBac transposon inserted into CSB intron 5 early in the primate lineage...