PFKP

Summary

Gene Symbol: PFKP
Description: phosphofructokinase, platelet
Alias: ATP-PFK, PFK-C, PFK-P, PFKF, ATP-dependent 6-phosphofructokinase, platelet type, 6-phosphofructokinase type C, 6-phosphofructokinase, platelet type, phosphofructo-1-kinase isozyme C, phosphofructokinase 1, phosphohexokinase
Species: human
Products:     PFKP

Top Publications

  1. Hannemann A, Jandrig B, Gaunitz F, Eschrich K, Bigl M. Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines. Gene. 2005;345:237-47 pubmed
    In humans three isoforms of 6-phosphofructo-1-kinase (PFK) exist. Among them platelet-type PFK (PFKP) is highly abundant in the brain...
  2. Scuteri A, Sanna S, Chen W, Uda M, Albai G, Strait J, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3:e115 pubmed
    ..Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight...
  3. Peng M, Yang D, Hou Y, Liu S, Zhao M, Qin Y, et al. Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis. Cell Death Dis. 2019;10:228 pubmed publisher
    ..and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes...
  4. Lang L, Chemmalakuzhy R, Shay C, Teng Y. PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism. Adv Exp Med Biol. 2019;1134:243-258 pubmed publisher
    ..Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism...
  5. Bjerre M, Strand S, Nørgaard M, Kristensen H, Rasmussen A, Mortensen M, et al. Aberrant DOCK2, GRASP, HIF3A and PKFP Hypermethylation has Potential as a Prognostic Biomarker for Prostate Cancer. Int J Mol Sci. 2019;20: pubmed publisher
    ..eight top candidate markers (cg12799885, DOCK2, FBXO30, GRASP, HIF3A, MOB3B, PFKP, and TPM4) that were specifically hypermethylated in PCa tissue samples and hypomethylated in other ..
  6. Deng X, Li Z, Xiong R, Liu J, Liu R, Peng J, et al. FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis. Biomed Pharmacother. 2019;109:1659-1669 pubmed publisher
    ..Notably, FS-7 noticeably down-regulated glycolysis-related protein HIF-1α, HK-II and PFKP expression in a concentration-dependent manner, possibly causing glycolysis inhibition...
  7. dos Santos E, Varchetta R, de Lima C, Ispada J, Martinho H, Fontes P, et al. The effects of crocetin supplementation on the blastocyst outcome, transcriptomic and metabolic profile of in vitro produced bovine embryos. Theriogenology. 2019;123:30-36 pubmed publisher
    ..as well as up regulation of genes related to DNA damage, stress response and energy metabolism (MORF4L2, SOD1, TXN, PFKP, PGK1 and PPARGC1A)...
  8. Moussa M, Li M, Zheng H, Yang C, Yan S, Yu N, et al. Buffalo oocyte-secreted factors promote cumulus cells apoptosis and the rate of cGMP production but not steroidogenesis. Reprod Domest Anim. 2018;53:1523-1529 pubmed publisher
    ..were harvested for evaluation of the relative mRNA abundance of the genes encoding gap junction (GJA1), glycolysis (PFKP and LDHA), apoptosis (CASPASE-3 and BCL-2) and steroidogenesis (ER-β and PGR) by QRT-PCR, and CASPASE-3 proteins, ..
  9. Zhou K, Yao Y, He Z, Chen C, Zhang X, Yang K, et al. VDAC2 interacts with PFKP to regulate glucose metabolism and phenotypic reprogramming of glioma stem cells. Cell Death Dis. 2018;9:988 pubmed publisher
    ..in NSTCs relative to GSCs and coupled a glycolytic rate-limiting enzyme platelet-type of phosphofructokinase (PFKP) on mitochondrion to inhibit PFKP-mediated glycolysis required for GSC maintenance...

More Information

Publications62

  1. Liu X, Haines J, Mehanna E, Genet M, Ben Sahra I, Asara J, et al. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev. 2014;28:1917-28 pubmed publisher
    ..directly binds to the promoter and represses the transcription of critical glycolytic genes, including GLUT3, PFKP, and PKM...
  2. Xu W, Zeng F, Li S, Li G, Lai X, Wang Q, et al. Crosstalk of protein kinase C ε with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis. Cell Mol Life Sci. 2018;75:4583-4598 pubmed publisher
    ..either PKCε or Smad2/3 promoted aerobic glycolysis, expression of the glycolytic genes encoding HIF-1α, HKII, PFKP and MCT4, and tumor cell proliferation, while overexpression of PKCε or Smad3 enhanced aerobic glycolysis and cell ..
  3. Chen G, Liu H, Zhang Y, Liang J, Zhu Y, Zhang M, et al. Silencing PFKP inhibits starvation-induced autophagy, glycolysis, and epithelial mesenchymal transition in oral squamous cell carcinoma. Exp Cell Res. 2018;370:46-57 pubmed publisher
    ..We determined that the expression of the key glycolytic enzyme phosphofructokinase-platelet (PFKP) obviously increased under starvation conditions and that PFKP knockdown inhibited starvation-mediated glycolysis, ..
  4. Lee J, Liu R, Li J, Wang Y, Tan L, Li X, et al. EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Mol Cell. 2018;70:197-210.e7 pubmed publisher
    ..resulted in lysine acetyltransferase 5 (KAT5)-mediated K395 acetylation of the platelet isoform of phosphofructokinase 1 (PFKP) and subsequent translocation of PFKP to the plasma membrane, where the PFKP was phosphorylated at ..
  5. Ausina P, Da Silva D, Majerowicz D, Zancan P, Sola Penna M. Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms. Biomed Pharmacother. 2018;103:228-233 pubmed publisher
    ..In mammals, this enzyme exists as three different isoforms, PFKM, PFKL and PFKP, presenting different regulatory and catalytic properties...
  6. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, et al. GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells. Endocrinology. 2015;156:1860-72 pubmed publisher
    ..GATA4-depleted mLTC-1 cells had reduced expression of glycolytic genes (Hk1, Gpi1, Pfkp, and Pgam1), lower intracellular levels of ATP, and increased extracellular levels of glucose...
  7. Machado M, Caixeta E, Sudiman J, Gilchrist R, Thompson J, Lima P, et al. Fibroblast growth factor 17 and bone morphogenetic protein 15 enhance cumulus expansion and improve quality of in vitro-produced embryos in cattle. Theriogenology. 2015;84:390-8 pubmed publisher
    ..gene 6 [TNFAIP6], and pentraxin 3 [PTX3]) and markers of oocyte developmental competence (phosphofructokinase [PFKP], gremlin [GREM1], versican [VCAN], and the genomic progesterone receptor [nPR]) in cumulus cells...
  8. Boruszewska D, Sinderewicz E, Kowalczyk Zieba I, Grycmacher K, Woclawek Potocka I. The effect of lysophosphatidic acid during in vitro maturation of bovine cumulus-oocyte complexes: cumulus expansion, glucose metabolism and expression of genes involved in the ovulatory cascade, oocyte and blastocyst competence. Reprod Biol Endocrinol. 2015;13:44 pubmed publisher
    ..augmentation of GLUT1 expression in cumulus cells as well as stimulating lactate production via the enhancement of PFKP expression in cumulus cells...
  9. Zhai Y, Yao G, Rao F, Wang Y, Song X, Sun F. Excessive nerve growth factor impairs bidirectional communication between the oocyte and cumulus cells resulting in reduced oocyte competence. Reprod Biol Endocrinol. 2018;16:28 pubmed publisher
    ..After culture, mRNA expression levels of Pfkp and Ldha genes in cumulus cells (CCs) and Gdf9, Bmp15 and Fgf8 genes in oocytes, were determined by real-time ..
  10. Cervantes Anaya N, Ponciano Gómez A, López Álvarez G, Gonzalez Reyes C, Hernández García S, Cabañas Cortés M, et al. Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats. Tumour Biol. 2017;39:1010428317695932 pubmed publisher
    ..Based on a microarray analysis performed in our laboratory, we selected six genes-namely, ANXA2, DYNLT1, PFKP, PLA2G7, KRT19, and SNX10-as candidates for validation as tumor markers of liver cancer in a rat model...
  11. Calvier L, Chouvarine P, Legchenko E, Hoffmann N, Geldner J, Borchert P, et al. PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism. Cell Metab. 2017;25:1118-1134.e7 pubmed publisher
    ..VSMC proliferation, and regulates two glucose metabolism-related enzymes, platelet isoform of phosphofructokinase (PFKP, a PPARγ target, via miR-331-5p) and protein phosphatase 1 regulatory subunit 3G (PPP1R3G, a Smad3 target)...
  12. Yang X, Zheng K, Lin K, Zheng G, Zou H, Wang J, et al. Energy Metabolism Disorder as a Contributing Factor of Rheumatoid Arthritis: A Comparative Proteomic and Metabolomic Study. PLoS ONE. 2015;10:e0132695 pubmed publisher
    ..identified in our previous proteomic study shows that the enzymes of anaerobic catabolism were up-regulated (PFKP and LDHA), and the enzymes of aerobic oxidation and fatty acid oxidation were down-regulated (CS, DLST, PGD, ACSL4, ..
  13. Webb B, Dosey A, Wittmann T, Kollman J, Barber D. The glycolytic enzyme phosphofructokinase-1 assembles into filaments. J Cell Biol. 2017;216:2305-2313 pubmed publisher
    ..Recombinant liver PFK1 (PFKL) isoform, but not platelet PFK1 (PFKP) or muscle PFK1 (PFKM) isoforms, assembles into filaments...
  14. Kim N, Cha Y, Lee J, Lee S, Yang J, Yun J, et al. Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress. Nat Commun. 2017;8:14374 pubmed publisher
    ..Mechanistically, Snail regulates glycolytic activity via repression of phosphofructokinase, platelet (PFKP), a major isoform of cancer-specific phosphofructokinase-1 (PFK-1), an enzyme involving the first rate-limiting ..
  15. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez V, et al. GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells. Endocrinology. 2016;157:2416-31 pubmed publisher
    ..Furthermore, Gata4 gene silencing was associated with altered expression of Hk1, Gpi1, Pfkp, Pgam1, Gls2, Pdk3, Pkd4, and Ldhb, genes regulating the production of lactate, a key nutrient that SCs provide to ..
  16. Hammond E, Stewart B, Peek J, Shelling A, Cree L. Assessing embryo quality by combining non-invasive markers: early time-lapse parameters reflect gene expression in associated cumulus cells. Hum Reprod. 2015;30:1850-60 pubmed publisher
    ..5 kDa (NDUFA1), lactate dehydrogenase A (LDHA), phosphofructokinase platelet (PFKP) and solute carrier family 2 member 4 (SLC2A4), mitochondrial biogenesis (DNA directed RNA polymerase, ..
  17. Campen K, McNatty K, Pitman J. A protective role of cumulus cells after short-term exposure of rat cumulus cell-oocyte complexes to lifestyle or environmental contaminants. Reprod Toxicol. 2017;69:19-33 pubmed publisher
    ..THC) on gap junction genes (Gja1, Gja4) and proteins (GJA1), glucose metabolism genes (Gfpt1, Pfkp) and oocyte growth factor genes (Bmp15, Gdf9), as well as gap junction transfer rate, in rat cumulus-oocyte ..
  18. Chen Y, Xu Q, Ji D, Wei Y, Chen H, Li T, et al. Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia. Tumour Biol. 2016;37:6027-34 pubmed publisher
    ..Expressions of critical PPP genes such as G6PD, PFKL, PFKP, and PGLS were consistently upregulated in all altered cases...
  19. Matsuno Y, Onuma A, Fujioka Y, Emori C, Fujii W, Naito K, et al. Effects of porcine oocytes on the expression levels of transcripts encoding glycolytic enzymes in granulosa cells. Anim Sci J. 2016;87:1114-21 pubmed publisher
    ..roles in regulating the expression of transcripts encoding the glycolytic enzymes phosphofructokinase, platelet (PFKP) and lactate dehydrogenase A (LDHA) in granulosa cells in mice, but whether this is the case in pigs or other ..
  20. Leiherer A, Stoemmer K, Muendlein A, Saely C, Kinz E, Brandtner E, et al. Quercetin Impacts Expression of Metabolism- and Obesity-Associated Genes in SGBS Adipocytes. Nutrients. 2016;8: pubmed publisher
    ..significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated ..
  21. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser M, et al. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015;112:15372-7 pubmed publisher
  22. Wang J, Zhang P, Zhong J, Tan M, Ge J, Tao L, et al. The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma. Oncotarget. 2016;7:27142-57 pubmed publisher
    ..The mRNA level of the platelet isoform of phosphofructokinase (PFKP) is reported to be up-regulated in ccRCC patients...
  23. Sun C, Xiong D, Yan Y, Geng J, Liu M, Yao X. Genetic alteration in phosphofructokinase family promotes growth of muscle-invasive bladder cancer. Int J Biol Markers. 2016;31:e286-93 pubmed publisher
    ..database using the cBioPortal platform, we studied genetic alteration of genes within the PFK family (PFKL, PFKM, PFKP, PFKFB1, PFKFB2, PFKFB3, and PFKFB4)...
  24. Pandruvada S, Beauregard J, Benjannet S, Pata M, Lazure C, Seidah N, et al. Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking. Mol Cell Biol. 2016;36:507-21 pubmed publisher
    ..These Ostm1 molecular and cellular functions could elucidate all of the pathophysiologic mechanisms underlying the wide phenotypic spectrum of Ostm1-deficient mice. ..
  25. Meienhofer M, Lagrange J, Cottreau D, Lenoir G, Dreyfus J, Kahn A. Phosphofructokinase in human blood cells. Blood. 1979;54:389-400 pubmed
    ..This enzyme might represent a useful marker in the characterization of the leukemic cells. ..
  26. Morrison N, Simpson C, Fothergill Gilmore L, Boyd E, Connor J. Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15. Hum Genet. 1992;89:105-6 pubmed
    A cDNA for human platelet 6-phosphofructokinase (PFKP) has been isolated from a human Raji cell line cDNA library. Using this cDNA as a probe, the gene for human PFKP, previously mapped to chromosome 10pter-p11...
  27. Vora S, Seaman C, Durham S, Piomelli S. Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system. Proc Natl Acad Sci U S A. 1980;77:62-6 pubmed
    ..The structural heterogeneity of erythrocyte PFK provides a molecular genetic basis for the differential organ involvement observed in some inherited PFK deficiency states in which myopathy or hemolysis or both can occur. ..
  28. Martínez Costa O, Sánchez Martinez C, Sánchez V, Aragon J. Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites. FEBS Lett. 2007;581:3033-8 pubmed
    ..Grafting the N-terminus of PFK-M onto the C-terminus of the fructose-1,6-P(2) insensitive PFK-C restored transduction of this signal to the catalytic site, which significance is also discussed. ..
  29. Williams F, Bansal A, van Meurs J, Bell J, Meulenbelt I, Suri P, et al. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis. 2013;72:1141-8 pubmed publisher
    ..This gene has not previously been considered a candidate in LDD and further functional work is needed on this hitherto unsuspected pathway. ..
  30. Chen C, Liao D, Wang J, Liang Z, Yao Q. Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase. Thromb Res. 2014;133:222-8 pubmed publisher
    ..05). In addition, anti-hPS Ab specifically cross-interacted with platelet phosphofructokinase (PFKP) in HCAECs. Anti-hPS Ab was able to directly inhibit PFKP activities in HCAECs...
  31. Kloos M, Brüser A, Kirchberger J, Schöneberg T, Sträter N. Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation. Biochem J. 2015;469:421-32 pubmed publisher
    ..Whereas the nature of this conformational switch appears to be largely conserved in bacterial, yeast and mammalian Pfk, initiation of these changes differs significantly in eukaryotic Pfk. ..
  32. Zhou Y, Fang L, Du D, Zhou W, Feng X, Chen J, et al. Proteome identification of binding-partners interacting with cell polarity protein Par3 in Jurkat cells. Acta Biochim Biophys Sin (Shanghai). 2008;40:729-39 pubmed
    ..Our results have the potential to uncover novel functions of the cell polarity protein Par3 in blood cells. ..
  33. Kahn A, Meienhofer M, Cottreau D, Lagrange J, Dreyfus J. Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues. Hum Genet. 1979;48:93-108 pubmed
    ..Testis and red cell phosphofructokinase enzymes definitely include msucle-type aand liver-type subunits, associated in various hybrid forms. ..
  34. Nakajima H, Noguchi T, Yamasaki T, Kono N, Tanaka T, Tarui S. Cloning of human muscle phosphofructokinase cDNA. FEBS Lett. 1987;223:113-6 pubmed
    ..Like RMPFK, HMPFK also possessed the internal homology between C- and N-halves in its primary structure. Cloning of HMPFK cDNA will help to identify the molecular defect in patients with glycogenosis type VII (HMPFK deficiency). ..
  35. Eto K, Sakura H, Yasuda K, Hayakawa T, Kawasaki E, Moriuchi R, et al. Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet. Biochem Biophys Res Commun. 1994;198:990-8 pubmed
    ..Considerable amount of platelet-type PFK expression was demonstrated in brain, heart, kidney, colon and testis. ..
  36. Adam G, Sorensen E, Cravatt B. Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes. Mol Cell Proteomics. 2002;1:828-35 pubmed
  37. Andreasen C, Mogensen M, Borch Johnsen K, Sandbaek A, Lauritzen T, Sørensen T, et al. Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS ONE. 2008;3:e2872 pubmed publisher
    The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants...
  38. Moon J, Kim H, Koh E, Park S, Jin W, Park B, et al. Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer. J Biol Chem. 2011;286:23808-16 pubmed publisher
    ..glycolytic metabolism in breast cancer cells by up-regulating the platelet isoform of phosphofructokinase (PFKP). KLF4 activated the transcription of the PFKP gene by directly binding to the PFKP promoter...
  39. Park Y, Kim S, Han H, Sohn B, Kim J, Liang J, et al. Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520. Hepatology. 2013;58:182-91 pubmed publisher
    ..TARDBP regulates expression of the platelet isoform of phosphofructokinase (PFKP), the rate-limiting enzyme of glycolysis that catalyzes the irreversible conversion of fructose-6-phosphate to ..
  40. Wang Y, Mei Q, Ai Y, Li R, Chang L, Li Y, et al. Identification of lung cancer oncogenes based on the mRNA expression and single nucleotide polymorphism profile data. Neoplasma. 2015;62:966-73 pubmed publisher
    ..Also, 39 common genes, like PFKP (phosphofructokinase, platelet) and DGKH-rs11616202 (diacylglycerol kinase, eta) that enriched in sub-pathways such ..
  41. Prasad C, Södergren K, Andersson T. Reduced production and uptake of lactate are essential for the ability of WNT5A signaling to inhibit breast cancer cell migration and invasion. Oncotarget. 2017;8:71471-71488 pubmed publisher
    ..lactate production and caused selective down-regulation of the glycolytic enzyme phosphofructokinase platelet-type (PFKP). These events occurred in parallel with a WNT5A-induced inhibition of ?-catenin signaling...
  42. Wang G, Xu Z, Wang C, Yao F, Li J, Chen C, et al. Differential phosphofructokinase-1 isoenzyme patterns associated with glycolytic efficiency in human breast cancer and paracancer tissues. Oncol Lett. 2013;6:1701-1706 pubmed
    ..Thus, during the development of human breast cancer, the enhancement of glycolytic activity depends primarily on the conversion of the PFK-1, from PFK-L to PFK-P. ..
  43. Agostini M, Romeo F, Inoue S, Niklison Chirou M, Elia A, Dinsdale D, et al. Metabolic reprogramming during neuronal differentiation. Cell Death Differ. 2016;23:1502-14 pubmed publisher
    ..was linked to an increase in glucose uptake and enhanced GLUT3 mRNA expression and platelet isoform of phosphofructokinase 1 (PFKp) protein expression...
  44. Sanders E, Diehl S. Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma. Oncoscience. 2015;2:151-86 pubmed
    ..Genes that are highly over-expressed include ENO2, HK2, PFKP, SLC2A3, PDK1, and SLC16A1...
  45. Vora S, DiMauro S, Spear D, Harker D, Danon M. Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII. J Clin Invest. 1987;80:1479-85 pubmed
    ..The presence of a small amount of enzyme activity in the muscle may account for the atypical myopathy in this patient...
  46. Cowan J, Tariq M, Shaw C, Rao M, Belmont J, Lalani S, et al. Copy number variation as a genetic basis for heterotaxy and heterotaxy-spectrum congenital heart defects. Philos Trans R Soc Lond B Biol Sci. 2016;371: pubmed
    ..in Xenopus support a role for one of these novel candidates, the platelet isoform of phosphofructokinase-1 (PFKP) in heterotaxy...
  47. Simpson C, Fothergill Gilmore L. Isolation and sequence of a cDNA encoding human platelet phosphofructokinase. Biochem Biophys Res Commun. 1991;180:197-203 pubmed
    ..The platelet gene has been assigned to chromosome 10p15.2-p15.3 by using the cDNA clone as a biotinylated probe against human chromosome spreads (Morrison et al. 1991, submitted to Human Genetics). ..
  48. Lee J, Liu R, Li J, Zhang C, Wang Y, Cai Q, et al. Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis. Nat Commun. 2017;8:949 pubmed publisher
    b>Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis; however, its role and regulation in tumorigenesis are not well understood...
  49. Mahlknecht U, Chesney J, Hoelzer D, Bucala R. Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2). Int J Oncol. 2003;23:883-91 pubmed
    ..3-p15.2, and its locus is 3 million bp centromeric to PFKP, the platelet-type phosphofructokinase...
  50. Sanzey M, Abdul Rahim S, Oudin A, Dirkse A, Kaoma T, Vallar L, et al. Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma. PLoS ONE. 2015;10:e0123544 pubmed publisher
    ..The most drastic effect was observed for PFKP (PFK1, +21.8%) and PDK1 (+20.9%), followed by PGAM1 and ENO1 (+14.5% each), HK2 (+11.8%), ALDOA (+10...
  51. Webb B, Forouhar F, Szu F, Seetharaman J, Tong L, Barber D. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature. 2015;523:111-4 pubmed publisher
    ..Here we report the first structures of the mammalian PFK1 tetramer, for the human platelet isoform (PFKP), in complex with ATP-Mg(2+) and ADP at 3.1 and 3.4 Å, respectively...
  52. Raben N, Exelbert R, Spiegel R, Sherman J, Nakajima H, Plotz P, et al. Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency. Am J Hum Genet. 1995;56:131-41 pubmed
    ..The mutants expressed in yeast generate functional enzyme with modest changes in thermal stability. The advantages and limitations of the yeast system for expression of human mutant PFKs are discussed...
  53. Vora S. Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system. Blood. 1981;57:724-32 pubmed