Gene Symbol: PFDN1
Description: prefoldin subunit 1
Alias: PDF, PFD1, prefoldin subunit 1, prefoldin 1
Species: human
Products:     PFDN1

Top Publications

  1. Vainberg I, Lewis S, Rommelaere H, Ampe C, Vandekerckhove J, Klein H, et al. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell. 1998;93:863-73 pubmed
    ..We show that by directing target proteins to chaperonin, prefoldin promotes folding in an environment in which there are many competing pathways for nonnative proteins. ..
  2. Matson J. Random Transposon Mutagenesis of Vibrio cholerae. Methods Mol Biol. 2018;1839:39-44 pubmed publisher
    ..Here we present a detailed protocol for the use of plasmid pFD1 (containing the mariner transposon magellan3) to create mutant libraries in V. cholerae.
  3. Zhang J, Han Q, Song Y, Chen Q, Xia X. Analysis of Subcellular Prefoldin 1 Redistribution During Rabies Virus Infection. Jundishapur J Microbiol. 2015;8:e24757 pubmed publisher aimed to investigate the change in the subcellular distribution and expression of the host protein Prefoldin subunit 1 (PFDN1) in RABV-infected cells and the viral expression of plasmids in the transfected cells...
  4. Simons C, Staes A, Rommelaere H, Ampe C, Lewis S, Cowan N. Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding. J Biol Chem. 2004;279:4196-203 pubmed
    ..Here we demonstrate that functional PFD can spontaneously assemble from its six constituent individual subunits (PFD1-PFD6), each expressed as a recombinant protein...
  5. Iijima M, Kano Y, Nohno T, Namba M. Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines. Acta Med Okayama. 1996;50:73-7 pubmed
    ..These results suggest that the C-1 gene product may function as a transcription factor related to the cell cycle. ..
  6. Wang P, Zhao J, Yang X, Guan S, Feng H, Han D, et al. PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization. Med Oncol. 2015;32:264 pubmed publisher
    ..PFDN) subunits have been reported upregulated in various tumor types, while the expression and functions of PFDN1 (PFDN subunit 1) in colorectal cancer (CRC) are not well elucidated...
  7. Narita R, Kitaura H, Torii A, Tashiro E, Miyazawa M, Ariga H, et al. Rabring7 degrades c-Myc through complex formation with MM-1. PLoS ONE. 2012;7:e41891 pubmed publisher
    ..These results suggest that Rabring7 stimulates c-Myc degradation via mono-ubiquitination of MM-1. ..
  8. Tsao M, Chao C, Yeh C. Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization. Biochem Biophys Res Commun. 2006;348:271-7 pubmed
    ..Functional prefoldin spontaneously assembles from its six subunits (prefoldin 1-6)...
  9. Horrigan S, Bartoloni L, Speer M, Fulton N, Kravarusic J, Ramesar R, et al. A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences. Genomics. 1999;57:24-35 pubmed
    ..The study demonstrates the utility of a radiation hybrid breakpoint panel for correction of map errors and for the efficient identification of new transcript units in a large genomic interval. ..

More Information


  1. Gstaiger M, Luke B, Hess D, Oakeley E, Wirbelauer C, Blondel M, et al. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science. 2003;302:1208-12 pubmed
    ..Thus, URI is a component of a signaling pathway that coordinates nutrient availability with gene expression. ..
  2. Bruneel A, Labas V, Mailloux A, Sharma S, Vinh J, Vaubourdolle M, et al. Proteomic study of human umbilical vein endothelial cells in culture. Proteomics. 2003;3:714-23 pubmed
    ..The presented annotated 2-D maps of HUVECs will be soon available on the web at http://www. ..
  3. Martín Benito J, Boskovic J, Gomez Puertas P, Carrascosa J, Simons C, Lewis S, et al. Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. EMBO J. 2002;21:6377-86 pubmed
    ..This defines the phasing of the CCT rings and suggests a handoff mechanism for PFD. ..
  4. Munnia A, Schutz N, Romeike B, Maldener E, Glass B, Maas R, et al. Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. Oncogene. 2001;20:4853-63 pubmed
    ..of the TX3868 cell line identified the nuclear mitotic apparatus protein (NuMA), the KIAA1009 protein, and prefoldin subunit 1 (PFDN1) as potential interacting partners of GAS41...
  5. Cowan N, Lewis S. A chaperone with a hydrophilic surface. Nat Struct Biol. 1999;6:990-1 pubmed
    ..The structure of the yeast homolog of cofactor A, Rbl2p, shows it to be a dimer with largely hydrophilic surfaces, reflecting the fact that it interacts with quasi-native, not unfolded, beta-tubulin. ..
  6. Stirling P, Cuellar J, Alfaro G, El Khadali F, Beh C, Valpuesta J, et al. PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. J Biol Chem. 2006;281:7012-21 pubmed
    ..We propose that the antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo. ..
  7. Hartl F, Hayer Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science. 2002;295:1852-8 pubmed
    ..Understanding how the thousands of different proteins synthesized in a cell use this chaperone machinery has profound implications for biotechnology and medicine. ..
  8. Rommelaere H, De Neve M, Neirynck K, Peelaers D, Waterschoot D, Goethals M, et al. Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families. J Biol Chem. 2001;276:41023-8 pubmed
    ..In addition, they also compete with tubulins, suggesting that these target proteins contact similar prefoldin subunits. ..
  9. Wang D, Shi W, Tang Y, Liu Y, He K, Hu Y, et al. Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression. Oncogene. 2017;36:885-898 pubmed publisher
    ..Here, we report a marked increase in prefoldin subunit 1 (PFDN1) levels during the transforming growth factor (TGF)-?1-mediated epithelial-mesenchymal transition (..
  10. Jun G, Chung J, Mez J, Barber R, Beecham G, Bennett D, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017;13:727-738 pubmed publisher single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ?4 allele with NFIC ..
  11. Hansen W, Cowan N, Welch W. Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins. J Cell Biol. 1999;145:265-77 pubmed
    ..We conclude that PFD functions by selectively targeting nascent actin and tubulin chains pending their transfer to CCT for final folding and/or assembly. ..