PEX5L

Summary

Gene Symbol: PEX5L
Description: peroxisomal biogenesis factor 5-like
Alias: PEX5R, PEX5RP, PXR2, PXR2B, TRIP8b, PEX2-related protein, PEX5-like protein, PEX5-related protein, Pex5p-related protein, peroxin-5-related protein, peroxisome biogenesis factor 5-like, tetratricopeptide repeat-containing Rab8b-interacting protein
Species: human

Top Publications

  1. pmc Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals
    L Amery
    Katholieke Universiteit Leuven, Campus Gasthuisberg O N, Departement Moleculaire Celbiologie, Afdeling Farmacologie, Herestraat 49, B 3000 Leuven, Belgium
    Biochem J 357:635-46. 2001
  2. doi TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels
    Zhuo Huang
    Department of Pharmacology, UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom
    J Neurosci 32:14835-48. 2012
  3. pmc The molecular biology of vestibular schwannomas and its association with hearing loss: a review
    Erika Celis-Aguilar
    Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, 14269 Ciudad de México, DF, Mexico
    Genet Res Int 2012:856157. 2012
  4. pmc Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels
    John R Bankston
    Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:7899-904. 2012
  5. doi Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b
    Marc Fransen
    Katholieke Universiteit Leuven, Campus Gasthuisberg O and N 1, Departement Moleculaire Celbiologie, LIPIT, Leuven, Belgium
    Biochim Biophys Acta 1783:864-73. 2008
  6. pmc Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites
    Ye Han
    Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 286:20823-34. 2011
  7. pmc Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia
    Xueling Sim
    Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
    PLoS Genet 7:e1001363. 2011
  8. pmc TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites
    Bina Santoro
    Department of Neuroscience and Pharmacology, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    J Neurosci 31:4074-86. 2011
  9. doi Interaction defect of the medium isoform of PTS1-receptor Pex5p with PTS2-receptor Pex7p abrogates the PTS2 protein import into peroxisomes in mammals
    Masanori Honsho
    Department of Biology, Faculty of Sciences, Kyushu University Graduate School, Higashi ku, Fukuoka, Japan
    J Biochem 149:203-10. 2011
  10. doi Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation
    Gerd Zolles
    Institute of Physiology, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany
    Neuron 62:814-25. 2009

Research Grants

  1. TRAINING PROGRAM IN SYSTEMS AND BEHAVIORAL NEUROSCIENCE
    Diane Lipscombe; Fiscal Year: 2007
  2. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2009
  3. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2009
  4. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2010
  5. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2006
  6. Interdisciplinary Predoctoral Neuroscience Training Program
    Diane Lipscombe; Fiscal Year: 2007
  7. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2007
  8. NEURONAL CALCIUM CHANNELS--REGULATION AND FUNCTION
    Diane Lipscombe; Fiscal Year: 2000
  9. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2004
  10. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2006

Scientific Experts

  • Marc Fransen
  • B Santoro
  • Diane Lipscombe
  • G Dodt
  • Alan S Lewis
  • Dane M Chetkovich
  • John R Bankston
  • Zhuo Huang
  • Erika Celis-Aguilar
  • Masanori Honsho
  • Ye Han
  • Xueling Sim
  • Merel S Ebberink
  • Gerd Zolles
  • Yukio Fujiki
  • Non Miyata
  • Xiaojian Wang
  • Frank DiMaio
  • Manuel Nistal
  • Luis Lassaletta
  • William N Zagotta
  • F Yuri Rodrigues
  • Miguel Torres-Martin
  • Stacey S Camp
  • Mala M Shah
  • Javier Gavilan
  • L Amery
  • Rafael Lujan
  • Juan A Rey
  • Javier S Castresana
  • Jose Martínez-Hernández
  • Yoav Noam
  • Mark Seielstad
  • Rick Twee Hee Ong
  • Yik Ying Teo
  • Jianjun Liu
  • Wytse J Wadman
  • Michael Boehnke
  • Chen Suo
  • Wan Ting Tay
  • E Shyong Tai
  • Tallie Z Baram
  • Kamran Ghaedi
  • Tien Yin Wong
  • Johnie J Gallagher
  • Yasuko Hashiguchi
  • Daniel Peng Keat Ng
  • Kee Seng Chia
  • Wolfgang Bildl
  • Peter G Barth
  • Janet Koster
  • Petra A W Mooyer
  • Ronald J A Wanders
  • Alexander Pfeifer
  • Uwe Schulte
  • Jochen Roeper
  • Andreas Vlachos
  • Peter T Clayton
  • Hans R Waterham
  • Daniela Wenzel
  • Francois J M Eyskens
  • Nikolaj Klocker
  • Carlo Dionisi-Vici
  • Conny J M Dekker
  • Andreas Hofmann
  • Bernd Fakler
  • Bernd K Fleischmann
  • Thomas Deller
  • Catrin S Müller
  • Jörg Oliver Thumfart
  • N Braverman
  • Taoyong Chen
  • Hongzhe Li
  • Xuetao Cao
  • Tao Wan
  • Lihuang Zhang
  • Hongying Sun
  • Bin Liu
  • Jianming Qiu
  • Nan Li
  • H Sano
  • J Snider
  • J Van Looy
  • P P Van Veldhoven
  • G P Mannaerts
  • S J Gould
  • D Valle

Detail Information

Publications17

  1. pmc Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals
    L Amery
    Katholieke Universiteit Leuven, Campus Gasthuisberg O N, Departement Moleculaire Celbiologie, Afdeling Farmacologie, Herestraat 49, B 3000 Leuven, Belgium
    Biochem J 357:635-46. 2001
    ..in an in vitro peroxisome-targeting signal 1 (PTS1)-binding assay, we refer to them as 'Pex5p-related proteins' (Pex5Rp)...
  2. doi TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels
    Zhuo Huang
    Department of Pharmacology, UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom
    J Neurosci 32:14835-48. 2012
    ..HCN channel trafficking to dendrites is regulated by the protein, TRIP8b. Additionally, altered TRIP8b expression may be one mechanism underlying seizure-induced dendritic HCN channel ..
  3. pmc The molecular biology of vestibular schwannomas and its association with hearing loss: a review
    Erika Celis-Aguilar
    Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, 14269 Ciudad de México, DF, Mexico
    Genet Res Int 2012:856157. 2012
    ..cyclin D1, expression of B7-H1, increased expression of the platelet-derived growth factor A, underexpression of PEX5L, RAD54B, and PSMAL, and overexpression of CEA...
  4. pmc Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels
    John R Bankston
    Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:7899-904. 2012
    ..b>TRIP8b (tetratricopetide repeat-containing Rab8b-interacting protein) is a recently discovered accessory subunit of ..
  5. doi Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b
    Marc Fransen
    Katholieke Universiteit Leuven, Campus Gasthuisberg O and N 1, Departement Moleculaire Celbiologie, LIPIT, Leuven, Belgium
    Biochim Biophys Acta 1783:864-73. 2008
    ..One such TPR-protein, TRIP8b, was originally identified in rat as an interaction partner of Rab8b, and its human orthologue as a protein ..
  6. pmc Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites
    Ye Han
    Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 286:20823-34. 2011
    ..Tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) is an auxiliary subunit for neuronal hyperpolarization-activated cyclic nucleotide-gated (HCN) channels...
  7. pmc Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia
    Xueling Sim
    Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
    PLoS Genet 7:e1001363. 2011
    ..These findings highlight the value of surveying across diverse racial/ethnic groups towards the fine-mapping efforts for the casual variants and also of the search for variants, which may be population-specific...
  8. pmc TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites
    Bina Santoro
    Department of Neuroscience and Pharmacology, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    J Neurosci 31:4074-86. 2011
    ..cyclic nucleotide-regulated (HCN) channels in the brain associate with their auxiliary subunit TRIP8b (also known as PEX5R), a cytoplasmic protein expressed as a family of alternatively spliced isoforms...
  9. doi Interaction defect of the medium isoform of PTS1-receptor Pex5p with PTS2-receptor Pex7p abrogates the PTS2 protein import into peroxisomes in mammals
    Masanori Honsho
    Department of Biology, Faculty of Sciences, Kyushu University Graduate School, Higashi ku, Fukuoka, Japan
    J Biochem 149:203-10. 2011
    ..1 nt upstream of exon 7 encoding Pex5pL specific 37-amino acid insertion, thereby generating 21-nt deleted mRNA of PEX5L in ZPEG241...
  10. doi Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation
    Gerd Zolles
    Institute of Physiology, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany
    Neuron 62:814-25. 2009
    ..Using affinity purification and high-resolution mass spectrometry, we identify the PEX5R/Trip8b protein as the beta subunit of HCN channels in the mammalian brain...
  11. doi Tripping the HCN breaker
    Diane Lipscombe
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 62:747-50. 2009
    ..In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a bidirectional spin.
  12. doi Genotype-phenotype correlation in PEX5-deficient peroxisome biogenesis defective cell lines
    Merel S Ebberink
    Laboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Hum Mutat 30:93-8. 2009
    ..Alternative splicing of PEX5 results in two protein variants, PEX5S and PEX5L. PEX5S is exclusively involved in PTS1 protein import, whereas PEX5L mediates the import of both PTS1 and PTS2 ..
  13. pmc Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export
    Non Miyata
    Department of Biology, Faculty of Sciences, Kyushu University Graduate School, Higashi ku, Fukuoka, Japan
    Mol Cell Biol 25:10822-32. 2005
    ..The longer isoform of Pex5, Pex5L, also transports Pex7-PTS2 protein complexes. After unloading the cargoes, Pex5 returns to the cytosol...
  14. ncbi Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction
    Bina Santoro
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 24:10750-62. 2004
    ..We identified a brain-specific protein, which has been previously termed TRIP8b (for TPR-containing Rab8b interacting protein) and PEX5Rp (for Pex5p-related protein), that specifically interacts ..
  15. ncbi A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization
    Xiaojian Wang
    Institute of Immunology, Zhejiang University, Hangzhou 310031, People s Republic of China
    J Biol Chem 279:45855-64. 2004
    ....
  16. ncbi Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p
    G Dodt
    Institut fur Physiologische Chemie, Systembiochemie Ruhr Universität, 44801 Bochum, Germany
    J Biol Chem 276:41769-81. 2001
    ..Human cells generate two isoforms of PEX5 through alternative splicing, PEX5S and PEX5L, and PEX5L contains an additional insert 37 amino acids long...
  17. ncbi An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes
    N Braverman
    Department of Pediatrics, Ruhr Universitat, Bochum, Germany q
    Hum Mol Genet 7:1195-205. 1998
    ..PEX5 expression and found that it undergoes alternative splicing, producing two transcripts, one containing (PEX5L) and one lacking (PEX5S) a 111 bp internal exon...

Research Grants25

  1. TRAINING PROGRAM IN SYSTEMS AND BEHAVIORAL NEUROSCIENCE
    Diane Lipscombe; Fiscal Year: 2007
    ..These include mentorship, laboratory research, grant writing, research seminars, retreats, skills workshops, and journal clubs. Funds are requested for five years of support for four postdoctoral trainees. ..
  2. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2009
    ..A defect in alternative splicing following nerve injury could contribute to aberrant pain processing and the de-habilitating symptoms of neuropathic pain. ..
  3. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2009
    ..2. This novel interaction is likely to mediate coupling of the CaV2.2 channel to the synaptic release machinery (aim 3). ..
  4. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2010
    ..By studying a novel form of the N-type calcium channel in the pain pathway, our studies of novel knock-in mice should lead to new strategies for inhibiting the activity of this N-type calcium channel and alleviating pain sufferers. ) ..
  5. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2006
    ..Pharmacologically distinct splice isoforms preferentially expressed in specific tissues or cell types offer exciting new targets for the design of highly specific drugs ..
  6. Interdisciplinary Predoctoral Neuroscience Training Program
    Diane Lipscombe; Fiscal Year: 2007
    ....
  7. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2007
    ..2. This novel interaction is likely to mediate coupling of the CaV2.2 channel to the synaptic release machinery (aim 3). ..
  8. NEURONAL CALCIUM CHANNELS--REGULATION AND FUNCTION
    Diane Lipscombe; Fiscal Year: 2000
    ..A better appreciation of the inter-relationship between different classes of Ca and K channel currents will provide new insights into the mechanisms by which neuronal excitability and neurotransmitter release are regulated. ..
  9. Neural Calcium Channels-Regulation and Function
    Diane Lipscombe; Fiscal Year: 2004
    ..Consequently, the identification of tissue-specific sites of alternative splicing may offer new strategies for improving specificity of drug action. ..
  10. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2006
    ..A defect in alternative splicing following nerve injury could contribute to aberrant pain processing and the de-habilitating symptoms of neuropathic pain. ..
  11. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2009
    ..A defect in alternative splicing following nerve injury could contribute to aberrant pain processing and the de-habilitating symptoms of neuropathic pain. ..