PEX14

Summary

Gene Symbol: PEX14
Description: peroxisomal biogenesis factor 14
Alias: NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal membrane protein PEX14, NF-E2 associated polypeptide 2, PTS1 receptor docking protein, peroxin-14, peroxisomal membrane anchor protein PEX14, peroxisomal membrane anchor protein Pex14p
Species: human
Products:     PEX14

Top Publications

  1. Chang C, Warren D, Sacksteder K, Gould S. PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. J Cell Biol. 1999;147:761-74 pubmed
    ..These and other results lead us to propose that PEX12 and PEX10 play direct roles in peroxisomal matrix protein import downstream of the receptor docking event. ..
  2. Will G, Soukupova M, Hong X, Erdmann K, Kiel J, Dodt G, et al. Identification and characterization of the human orthologue of yeast Pex14p. Mol Cell Biol. 1999;19:2265-77 pubmed
    b>Pex14p is a central component of the peroxisomal protein import machinery, which has been suggested to provide the point of convergence for PTS1- and PTS2-dependent protein import in yeast cells...
  3. Fransen M, Terlecky S, Subramani S. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. Proc Natl Acad Sci U S A. 1998;95:8087-92 pubmed
    ..Previous studies have identified two yeast proteins, Pex14p and Pex13p, as Pex5p-binding proteins...
  4. Zhang M, Yang S, Shi M, Zhang S, Zhang T, Li Y, et al. Regulatory Roles of Peroxisomal Metabolic Pathways Involved in Musk Secretion in Muskrats. J Membr Biol. 2019;252:61-75 pubmed publisher
    ..We detected 21 genes in the peroxisomal metabolic pathways, including PEX14(peroxin-14) and ACOX3(acyl-CoA oxidase), which exhibited significant differential expression between the musk-..
  5. Klümper J, Oeljeklaus S, Warscheid B, Erdmann R, Schliebs W. Using Pull Down Strategies to Analyze the Interactome of Peroxisomal Membrane Proteins in Human Cells. Subcell Biochem. 2018;89:261-285 pubmed publisher
    ..As exemplified for Protein A-tagged human PEX14, one of the central constituents of the peroxisomal matrix protein import machinery, MS analyses of the affinity-..
  6. Hagmann V, Sommer S, Fabian P, Bierlmeier J, van Treel N, Mootz H, et al. Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery. Sci Rep. 2018;8:16014 pubmed publisher
    ..Here, we investigated the protein interactions of monoubiquitinated PEX5 with the docking proteins PEX13, PEX14 and the REM. "Click" chemistry was used to synthesise monoubiquitinated recombinant PEX5...
  7. Guder P, Lotz Havla A, Woidy M, Reiß D, Danecka M, Schatz U, et al. Isoform-specific domain organization determines conformation and function of the peroxisomal biogenesis factor PEX26. Biochim Biophys Acta Mol Cell Res. 2019;1866:518-531 pubmed publisher
    ..PEX26 associates with the peroxisomal translocation pore via PEX14 and a splice variant (PEX26Δex5) of unknown function has been reported...
  8. Schwerter D, Grimm I, Girzalsky W, Erdmann R. Receptor recognition by the peroxisomal AAA complex depends on the presence of the ubiquitin moiety and is mediated by Pex1p. J Biol Chem. 2018;293:15458-15470 pubmed publisher
    ..In vitro assays revealed its interaction at WT level with the native cargo protein Pcs60p and Pex14p, a constituent of the receptor docking complex...
  9. Mukai S, Matsuzaki T, Fujiki Y. The cytosolic peroxisome-targeting signal (PTS)-receptors, Pex7p and Pex5pL, are sufficient to transport PTS2 proteins to peroxisomes. Biochim Biophys Acta Mol Cell Res. 2019;1866:441-449 pubmed publisher
    ..import and show that the PTS2 pre-import complexes comprising Pex7p, Pex5p, and Hsc70 isolated from the cytosol of pex14 Chinese hamster ovary cell mutant ZP161 is import-competent...

More Information

Publications74

  1. Jiang L, Hara Kuge S, Yamashita S, Fujiki Y. Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II. Genes Cells. 2015;20:36-49 pubmed publisher
    Pexophagy can be experimentally induced in mammalian cells by removing the culture serum. Pex14p, a peroxisomal membrane protein essential for matrix protein import in docking of soluble receptor Pex5p, is involved in the mammalian ..
  2. Yu Z, Ma J, Li X, Liu Y, Li M, Wang L, et al. Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions. Sci Rep. 2018;8:9972 pubmed publisher
    ..ECIs) and found that the ECIs were majorly composed of sequestosome 1/P62, neighbor of BRCA1 gene 1 (NBR1), PEX14, and CATALASE1 (CAT1)...
  3. Yoshida Y, Niwa H, Honsho M, Itoyama A, Fujiki Y. Pex11mediates peroxisomal proliferation by promoting deformation of the lipid membrane. Biol Open. 2015;4:710-21 pubmed publisher
    ..The fission-deficient peroxisomes exhibited an elongated morphology, and peroxisomal marker proteins, such as Pex14p or matrix proteins harboring peroxisomal targeting signal 1, were discernible in a segmented staining pattern, ..
  4. Lee J, Dutta R, Maharjan Y, Liu Z, Lim J, Kim S, et al. Catalase inhibition induces pexophagy through ROS accumulation. Biochem Biophys Res Commun. 2018;501:696-702 pubmed publisher
    ..decreased the number of peroxisomes and resulted in the downregulation of peroxisomal proteins, such as PMP70 and PEX14 under serum starvation...
  5. Hojjat H, Jardim A. Identification of Leishmania donovani peroxin 14 residues required for binding the peroxin 5 receptor proteins. Biochem J. 2015;465:247-57 pubmed publisher
    ..Biochemical studies revealed that these point mutations did not alter either the secondary or quaternary structure of LdPEX14 and indicated that the latter residues were critical for stabilizing the LdPEX5-LdPEX14 interaction. ..
  6. Mbekeani A, Stanley W, Kalel V, Dahan N, Zalckvar E, Sheiner L, et al. Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii. Genes (Basel). 2018;9: pubmed publisher
    ..receptor Pex5 and are then imported into the peroxisome via the membrane-bound protein complex formed by Pex13 and Pex14. Surprisingly, whilst Pex5 is clearly identifiable, Pex13 and, perhaps, Pex14 are apparently absent from the ..
  7. Pan R, Satkovich J, Hu J. E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis. Proc Natl Acad Sci U S A. 2016;113:E7307-E7316 pubmed
    ..SP1 interacts physically with the two components of the peroxisome protein docking complex PEX13-PEX14 and the (RING)-finger peroxin PEX2...
  8. Cyr N, Smith T, Boisselier E, Leroux L, Kottarampatel A, Davidsen A, et al. The hydrophobic region of the Leishmania peroxin 14: requirements for association with a glycosome mimetic membrane. Biochem J. 2018;475:511-529 pubmed publisher
    ..into the Leishmania glycosome requires docking of the cargo-loaded peroxin 5 (PEX5) receptor to the peroxin 14 (PEX14) bound to the glycosome surface. To examine the LdPEX14-membrane interaction, we purified L...
  9. Bhogal M, Lanyon Hogg T, Johnston K, Warriner S, Baker A. Covalent Label Transfer between Peroxisomal Importomer Components Reveals Export-driven Import Interactions. J Biol Chem. 2016;291:2460-8 pubmed publisher
    ..This technique was capable of identifying the PEX5-PEX14 interaction as the first interaction of the import process through competition experiments...
  10. Vijayan V, Srinu T, Karnati S, Garikapati V, Linke M, Kamalyan L, et al. A New Immunomodulatory Role for Peroxisomes in Macrophages Activated by the TLR4 Ligand Lipopolysaccharide. J Immunol. 2017;198:2414-2425 pubmed publisher
    ..In contrast, disturbing peroxisome function by knockdown of peroxisomal gene Pex14 or Mfp2 markedly increased the LPS-dependent upregulation of the proinflammatory proteins COX-2 and TNF-..
  11. Jin A, Lee J, Kim M, Kwak S, Kim S, Song K, et al. 2,2'-dipyridyl induces pexophagy. Biochem Biophys Res Commun. 2016;469:941-7 pubmed publisher
    ..originating from peroxisomes and a decrease in the expression of peroxisomal proteins such as catalase, Pex14, and PMP70...
  12. Knoops K, de Boer R, Kram A, van der Klei I. Yeast pex1 cells contain peroxisomal ghosts that import matrix proteins upon reintroduction of Pex1. J Cell Biol. 2015;211:955-62 pubmed publisher
    ..matrix proteins but are the sole sites of the major peroxisomal membrane proteins Pex2, Pex10, Pex11, Pex13, and Pex14. Upon reintroduction of Pex1 in Pex1-deficient cells, these peroxisomal membrane remnants (ghosts) rapidly ..
  13. Caswell J, Camarda R, Zhou A, Huntsman S, Hu D, Brenner S, et al. Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors. Hum Mol Genet. 2015;24:7421-31 pubmed publisher
    ..05 (BABAM1, DCLRE1B/PHTF1, PEX14, RAD51L1, SRGAP2D and STXBP4)...
  14. Hojjat H, Jardim A. The Leishmania donovani peroxin 14 binding domain accommodates a high degeneracy in the pentapeptide motifs present on peroxin 5. Biochim Biophys Acta. 2015;1850:2203-12 pubmed publisher
  15. Montilla Martinez M, Beck S, Klümper J, Meinecke M, Schliebs W, Wagner R, et al. Distinct Pores for Peroxisomal Import of PTS1 and PTS2 Proteins. Cell Rep. 2015;13:2126-34 pubmed publisher
    ..A pore consisting of the PTS1 receptor Pex5 and the docking protein Pex14 imports PTS1 proteins...
  16. Kinoshita N, Matsuura A, Fujiki Y. Peroxisome biogenesis: a novel inducible PEX19 splicing variant is involved in early stages of peroxisome proliferation. J Biochem. 2017;161:297-308 pubmed publisher
    ..Non-prenylated Pex19p interacted with a membrane protein cargo, Pex14p, but more weakly than Pex19pi and the farnesylated Pex19p...
  17. Meinecke M, Bartsch P, Wagner R. Peroxisomal protein import pores. Biochim Biophys Acta. 2016;1863:821-7 pubmed publisher
    ..The identification of a water-filled pore that is mainly constituted by Pex5 and Pex14 led to the assumption that proteins are translocated through a large, probably transient, protein-conducting ..
  18. Qian G, Fan W, Ahlemeyer B, Karnati S, Baumgart Vogt E. Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors. PLoS ONE. 2015;10:e0143439 pubmed publisher
    ..activated the PPRE-mediated luciferase expression and up-regulated peroxisomal gene transcription (Pex11, Pex13, Pex14, Acox1 and Cat), whereas the PPARß antagonist GSK0660 led to repression of the PPRE and a decrease of the ..
  19. Chan A, Schummer A, Fischer S, Schröter T, Cruz Zaragoza L, Bender J, et al. Pex17p-dependent assembly of Pex14p/Dyn2p-subcomplexes of the peroxisomal protein import machinery. Eur J Cell Biol. 2016;95:585-597 pubmed publisher
    ..The docking-complex is composed of Pex13p, Pex14p and in yeast also Pex17p, whose function is still elusive...
  20. Yuan W, Veenhuis M, van der Klei I. The birth of yeast peroxisomes. Biochim Biophys Acta. 2016;1863:902-10 pubmed publisher
    ..This is especially evident for pex3 and pex19 mutants, where the localization of receptor docking proteins (Pex13, Pex14) resulted in the identification of peroxisomal membrane remnants, which do not contain other peroxisomal membrane ..
  21. Agrawal G, Fassas S, Xia Z, Subramani S. Distinct requirements for intra-ER sorting and budding of peroxisomal membrane proteins from the ER. J Cell Biol. 2016;212:335-48 pubmed publisher
    ..Although the docking subcomplex proteins (Pex13, Pex14, and Pex17) also required Pex19 for budding from the ER, they sorted to the pER independently of Pex3 and Pex19 ..
  22. Saho S, Satoh H, Kondo E, Inoue Y, Yamauchi A, Murata H, et al. Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells. Cancer Microenviron. 2016;9:93-105 pubmed publisher
    ..was produced selectively in the peroxisome after transportation of monomeric S100A11 through an interaction with PEX14, a peroxisome membrane protein, resulting in peroxisomal secretion of dimerized S100A11...
  23. Lee M, Sumpter R, Zou Z, Sirasanagandla S, Wei Y, Mishra P, et al. Peroxisomal protein PEX13 functions in selective autophagy. EMBO Rep. 2017;18:48-60 pubmed publisher
    ..mitophagy function of PEX13 is shared with another peroxin family member PEX3, but not with two other peroxins, PEX14 and PEX19, which are required for general autophagy...
  24. Morvay P, Baes M, Van Veldhoven P. Differential activities of peroxisomes along the mouse intestinal epithelium. Cell Biochem Funct. 2017;35:144-155 pubmed publisher
    ..b>PEX14 showed a similar profile, but was still substantial expressed in large intestinal epithelium...
  25. Sugiura A, Mattie S, Prudent J, McBride H. Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes. Nature. 2017;542:251-254 pubmed publisher
    ..are imported into mitochondria in mammalian cells in the absence of peroxisomes, including Pex3, Pex12, Pex13, Pex14, Pex26, PMP34 and ALDP...
  26. Suaste Olmos F, Zirión Martínez C, Takano Rojas H, Peraza Reyes L. Meiotic development initiation in the fungus Podospora anserina requires the peroxisome receptor export machinery. Biochim Biophys Acta Mol Cell Res. 2018;1865:572-586 pubmed publisher
    ..However, this defect is not seen in the absence of the receptors PEX5 and PEX7, or of the docking peroxins PEX14 and PEX14/17. Here we describe the function of the remaining uncharacterized P...
  27. Al Olama A, Kote Jarai Z, Berndt S, Conti D, Schumacher F, Han Y, et al. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet. 2014;46:1103-9 pubmed publisher
    ..These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease. ..
  28. Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, et al. PEX14 is required for microtubule-based peroxisome motility in human cells. J Cell Sci. 2011;124:1759-68 pubmed publisher
    ..Protein-A-tagged peroxin 14 (PEX14), a central component of the peroxisomal protein translocation machinery was genomically expressed in Flp-..
  29. Dawidowski M, Emmanouilidis L, Kalel V, Tripsianes K, Schorpp K, Hadian K, et al. Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science. 2017;355:1416-1420 pubmed publisher
    ..report a way to selectively kill Trypanosoma by blocking glycosomal/peroxisomal import that depends on the PEX14-PEX5 protein-protein interaction. We developed small molecules that efficiently disrupt the PEX14-PEX5 interaction...
  30. Macgregor S, Hewitt A, Hysi P, Ruddle J, Medland S, Henders A, et al. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Hum Mol Genet. 2010;19:2716-24 pubmed publisher
    ..0136). Furthermore, the Arg65Gly variant was found to have very low frequency (0.00066) in an additional set of 672 controls. ..
  31. Shimozawa N, Tsukamoto T, Nagase T, Takemoto Y, Koyama N, Suzuki Y, et al. Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene. Hum Mutat. 2004;23:552-8 pubmed
    ..The peroxisomal membrane protein PEX14 is a key component of the peroxisomal import machinery and may be the initial docking site for the ..
  32. Oliveira M, Reguenga C, Gouveia A, Guimaraes C, Schliebs W, Kunau W, et al. Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction. Biochim Biophys Acta. 2002;1567:13-22 pubmed
    ..One central component of this machinery is Pex14p, an intrinsic peroxisomal membrane protein probably involved in the docking of Pex5p, the receptor for PTS1-..
  33. Gavva N, Wen S, Daftari P, Moniwa M, Yang W, Yang Feng L, et al. NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor. Genomics. 2002;79:423-31 pubmed
    ..We have isolated a protein, NAPP2, which contains an aspartic-acid- and glutamic-acid-rich region and a nuclear localization signal...
  34. Amery L, Mannaerts G, Subramani S, Van Veldhoven P, Fransen M. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. Comb Chem High Throughput Screen. 2001;4:545-52 pubmed
    ..These results further demonstrate the suitability of the gVI-cDNA phage display technology for cDNA expression cloning using an antibody as a probe. ..
  35. Effelsberg D, Cruz Zaragoza L, Schliebs W, Erdmann R. Pex9p is a new yeast peroxisomal import receptor for PTS1-containing proteins. J Cell Sci. 2016;129:4057-4066 pubmed
    ..The new peroxin was designated Pex9p, and it interacts with the docking protein Pex14p and a subclass of PTS1-containing peroxisomal matrix enzymes...
  36. Wróblewska J, Cruz Zaragoza L, Yuan W, Schummer A, Chuartzman S, de Boer R, et al. Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins. Biochim Biophys Acta Mol Cell Res. 2017;1864:1656-1667 pubmed publisher
    ..microscopy and biochemical approaches, we show that a subset of the PMPs, including the receptor docking protein Pex14, localizes to membrane vesicles in S. cerevisiae pex3 cells...
  37. Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, et al. The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis. J Biol Chem. 1999;274:12593-604 pubmed
    ..The primary sequence showed 28 and 24% amino acid identity with the yeast Pex14p from Hansenula polymorpha and Saccharomyces cerevisiae, respectively; therefore, we termed this cDNA rat PEX14 (..
  38. Okumoto K, Abe I, Fujiki Y. Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p. J Biol Chem. 2000;275:25700-10 pubmed
    ..Hence, the RING finger peroxins are most likely to be involved in Pex5p-mediated matrix protein import into peroxisomes. ..
  39. Smith C, Poulter J, Levin A, Capasso J, Price S, Ben Yosef T, et al. Spectrum of PEX1 and PEX6 variants in Heimler syndrome. Eur J Hum Genet. 2016;24:1565-1571 pubmed publisher
    ..six further HS families, five with PEX6 variants and one with PEX1 variants, and show the patterns of Pex1, Pex14 and Pex6 immunoreactivity in the mouse retina. While Ratbi et al...
  40. Neuhaus A, Kooshapur H, Wolf J, Meyer N, Madl T, Saidowsky J, et al. A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes. J Biol Chem. 2014;289:437-48 pubmed publisher
    ..Receptor-cargo docking occurs at the membrane-associated protein Pex14. In human cells, this interaction is mediated by seven conserved diaromatic penta-peptide motifs (WXXX(F/Y) motifs)..
  41. Faber K, Haan G, Baerends R, Kram A, Veenhuis M. Normal peroxisome development from vesicles induced by truncated Hansenula polymorpha Pex3p. J Biol Chem. 2002;277:11026-33 pubmed
    ..These structures also contain Pex14p and can develop into functional peroxisomes after subsequent reintroduction of the full-length Pex3p protein...
  42. Garcia Closas M, Couch F, Lindstrom S, Michailidou K, Schmidt M, Brook M, et al. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013;45:392-8, 398e1-2 pubmed publisher
    ..05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers. ..
  43. Williams C, Schueller N, Thompson C, van den Berg M, van Haren S, Erdmann R, et al. The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition. BMC Biochem. 2011;12:12 pubmed publisher
    ..In this study, we have tested the contribution of a second, ancillary receptor-cargo binding site, which was found in addition to the characterised Peroxisomal Target Signal type 1...
  44. Nury T, Zarrouk A, Ragot K, Debbabi M, Riedinger J, Vejux A, et al. 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. J Steroid Biochem Mol Biol. 2017;169:123-136 pubmed publisher
    ..However, the Pex14 level was unchanged...
  45. Sacksteder K, Jones J, South S, Li X, Liu Y, Gould S. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol. 2000;148:931-44 pubmed
    ..This hypothesis is supported by the observation that the loss of PEX19 results in degradation of PMPs and/or mislocalization of PMPs to the mitochondrion. ..
  46. Fransen M, Brees C, Ghys K, Amery L, Mannaerts G, Ladant D, et al. Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. Mol Cell Proteomics. 2002;1:243-52 pubmed
    ..Finally, we show that the Pex5p-Pex13p interaction is bridged by Pex14p and that the latter molecule exists predominantly as a dimer in vivo...
  47. Liu F, Chen Y, Zhu G, Hysi P, Wu S, Adhikari K, et al. Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair. Hum Mol Genet. 2017;: pubmed publisher
    ..A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13...
  48. Shuptrine C, Ajina R, Fertig E, Jablonski S, Kim Lyerly H, Hartman Z, et al. An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection. Cancer Immunol Immunother. 2017;66:1529-1544 pubmed publisher
    ..that selectively regulated adaptive anti-tumor immunity and focused on five genes (CD47, TGFβ1, Sgpl1, Tex9 and Pex14) with the greatest impact...
  49. Dias A, Rodrigues T, Pedrosa A, Barros Barbosa A, Francisco T, Azevedo J. The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo. J Biol Chem. 2017;292:15287-15300 pubmed publisher
    ..Finally, we found that the interaction between PEX5 and PEX14, a major DTM component, is stable at pH 11.5...
  50. Fransen M, Vastiau I, Brees C, Brys V, Mannaerts G, Van Veldhoven P. Potential role for Pex19p in assembly of PTS-receptor docking complexes. J Biol Chem. 2004;279:12615-24 pubmed
    ..addition, through in vitro biochemical analysis, we show that Pex19p competes with Pex5p and Pex13p for binding to Pex14p, supporting a role for this peroxin in regulating assembly/disassembly of membrane-associated protein complexes...
  51. Nenicu A, Lüers G, Kovacs W, David M, Zimmer A, Bergmann M, et al. Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol Reprod. 2007;77:1060-72 pubmed
    ..Our results suggest a cell type-specific metabolic function of peroxisomes in the testis and point to an important role for peroxisomes in spermiogenesis and in the lipid metabolism of Sertoli cells. ..
  52. Neufeld C, Filipp F, Simon B, Neuhaus A, Schüller N, David C, et al. Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. EMBO J. 2009;28:745-54 pubmed publisher
    Protein import into peroxisomes depends on a complex and dynamic network of protein-protein interactions. Pex14 is a central component of the peroxisomal import machinery and binds the soluble receptors Pex5 and Pex19, which have ..
  53. Shiozawa K, Konarev P, Neufeld C, Wilmanns M, Svergun D. Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering. J Biol Chem. 2009;284:25334-42 pubmed publisher
    ..As the interaction of the cargo-loaded Pex5p receptor and the peroxisomal membrane protein Pex14p is the essential primary docking step, we have investigated the solution structure of these complexes by small ..
  54. Galiani S, Waithe D, Reglinski K, Cruz Zaragoza L, Garcia E, Clausen M, et al. Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins. J Biol Chem. 2016;291:16948-62 pubmed publisher
    ..to investigate with sub-60-nm resolution the heterogeneous spatial organization of the peroxisomal proteins PEX5, PEX14, and PEX11 around actively importing peroxisomes, showing distinct differences between these peroxins...
  55. Fransen M, Amery L, Hartig A, Brees C, Rabijns A, Mannaerts G, et al. Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b. Biochim Biophys Acta. 2008;1783:864-73 pubmed publisher
    ..The implications of these findings for the possible peroxisome-related functions of Pex5Rp/TRIP8b are discussed. ..
  56. Huybrechts S, Van Veldhoven P, Hoffman I, Zeevaert R, de Vos R, Demaerel P, et al. Identification of a novel PEX14 mutation in Zellweger syndrome. J Med Genet. 2008;45:376-83 pubmed publisher
    ..fibroblasts demonstrated that the cells contain peroxisomal remnants lacking apparent matrix protein content and PEX14, a central membrane component of the peroxisomal matrix protein import machinery...
  57. Woudenberg J, Rembacz K, van den Heuvel F, Woudenberg Vrenken T, Buist Homan M, Geuken M, et al. Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes. Hepatology. 2010;51:1744-53 pubmed publisher
    ..marker proteins (catalase, the 70 kDa peroxisomal membrane protein PMP70, the adrenoleukodystrophy protein ALDP, Pex14p, and the bile acid-coenzyme A:amino acid N-acyltransferase BAAT) in rat hepatocytes...
  58. Nguyen T, Bjorkman J, Paton B, Crane D. Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance. J Cell Sci. 2006;119:636-45 pubmed
  59. Nazarko T. Pexophagy is responsible for 65% of cases of peroxisome biogenesis disorders. Autophagy. 2017;13:991-994 pubmed publisher
    ..In recent years, it became clear that many peroxins (e.g., PEX3 and PEX14) play additional roles in peroxisome homeostasis (such as promoting autophagic degradation of peroxisomes or ..
  60. Freitas M, Francisco T, Rodrigues T, Alencastre I, Pinto M, Grou C, et al. PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14. J Biol Chem. 2011;286:40509-19 pubmed publisher
    ..Interestingly, the PEX5-catalase interaction is disrupted by the N-terminal domain of PEX14, a component of the docking/translocation machinery...
  61. Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y. Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import. Mol Cell Biol. 2002;22:1639-55 pubmed
    ..Pex5pL transports PTS1 proteins and Pex7p-PTS2 cargo complexes to the initial Pex5p-docking site, Pex14p, on peroxisome membranes, while Pex5pS translocates only PTS1 cargoes...
  62. Bodelon C, Oh H, Chatterjee N, Garcia Closas M, Palakal M, Sherman M, et al. Association between breast cancer genetic susceptibility variants and terminal duct lobular unit involution of the breast. Int J Cancer. 2017;140:825-832 pubmed publisher
    ..25). Six of the 62 SNPs (9.7%) were nominally associated with at least one TDLU measure: rs616488 (PEX14), rs11242675 (FOXQ1) and rs6001930 (MKL1) were associated with higher TDLU count (p?=?0.047, 0.045 and 0...
  63. Komatsuzaki S, Ogawa E, Shimozawa N, Sakamoto O, Haginoya K, Uematsu M, et al. First Japanese case of Zellweger syndrome with a mutation in PEX14. Pediatr Int. 2015;57:1189-92 pubmed publisher
    ..Most of the patients with this disease die before the age of 1 year. PEX14 is the 13th PEX gene responsible for peroxisome biogenesis disorders...
  64. Steinberg S, Wang S, Kim D, Mihalik S, Watkins P. Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. Biochem Biophys Res Commun. 1999;257:615-21 pubmed
    ..This orientation, coupled with the observation that hVLCS activates branched-chain fatty acids, suggests that hVLCS could play a role in the intraperoxisomal reactivation of pristanic acid produced via alpha-oxidation of phytanic acid. ..