perlecan

Summary

Gene Symbol: perlecan
Description: heparan sulfate proteoglycan 2
Alias: HSPG, PLC, PRCAN, SJA, SJS, SJS1, basement membrane-specific heparan sulfate proteoglycan core protein, endorepellin (domain V region), perlecan proteoglycan
Species: human
Products:     perlecan

Top Publications

  1. Mongiat M, Sweeney S, San Antonio J, Fu J, Iozzo R. Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J Biol Chem. 2003;278:4238-49 pubmed
    b>Perlecan, a ubiquitous basement membrane heparan sulfate proteoglycan, plays key roles in blood vessel growth and structural integrity...
  2. Allen J, Bateman J, Hansen U, Wilson R, Bruckner P, Owens R, et al. WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. J Biol Chem. 2006;281:7341-9 pubmed
    ..cartilage, WARP is highly specific for the chondrocyte pericellular microenvironment and co-localizes with perlecan, a prominent component of the chondrocyte pericellular region...
  3. Murdoch A, Dodge G, Cohen I, Tuan R, Iozzo R. Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal . J Biol Chem. 1992;267:8544-57 pubmed
    ..and deduced amino acid sequence of the major protein core of the human heparan sulfate proteoglycan HSPG2/perlecan of basement membranes. Eighteen overlapping cDNA clones comprise 14...
  4. Smeland S, Kolset S, Lyon M, Norum K, Blomhoff R. Binding of perlecan to transthyretin in vitro. Biochem J. 1997;326 ( Pt 3):829-36 pubmed
    ..Immunoprecipitation showed that the [35S]sulphate-labelled material contained perlecan. Further analysis by binding studies revealed specific and saturable binding of 125I-transthyretin to perlecan-..
  5. Göhring W, Sasaki T, Heldin C, Timpl R. Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope. Eur J Biochem. 1998;255:60-6 pubmed
    ..This identified several collagen types; laminin-1, nidogen, perlecan and BM-40 as potential ligands for PDGF with Kd values in the range 2-3200 nM...
  6. Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato J, Iozzo R. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. J Biol Chem. 2001;276:10263-71 pubmed
    b>Perlecan, a widespread heparan sulfate proteoglycan, functions as a bioactive reservoir for growth factors by stabilizing them against misfolding or proteolysis...
  7. Cailhier J, Sirois I, Laplante P, Lepage S, Raymond M, Brassard N, et al. Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis. J Biol Chem. 2008;283:27220-9 pubmed publisher
    ..These data demonstrate that caspase-3 activation is a novel pathway of importance for triggering extracellular CathL release and the cleavage of extracellular matrix components. ..
  8. Brown J, Sasaki T, Göhring W, Yamada Y, Timpl R. The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans. Eur J Biochem. 1997;250:39-46 pubmed
    Domain V of the major basement-membrane proteoglycan perlecan, a domain which consists of three laminin type G (LG) and four epidermal-growth-factor-like (EG) modules, was obtained in recombinant form by transfecting embryonic kidney ..
  9. Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock J, et al. The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7. J Biol Chem. 2000;275:7095-100 pubmed
    b>Perlecan is a multifaceted heparan sulfate proteoglycan that is expressed not only as an intrinsic constituent of basement membranes but also as a cell-surface and pericellular proteoglycan...

More Information

Publications119 found, 100 shown here

  1. Arikawa Hirasawa E, Wilcox W, Le A, Silverman N, Govindraj P, Hassell J, et al. Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene. Nat Genet. 2001;27:431-4 pubmed
    b>Perlecan is a large heparan sulfate (HS) proteoglycan present in all basement membranes and in some other tissues such as cartilage, and is implicated in cell growth and differentiation...
  2. Arikawa Hirasawa E, Le A, Nishino I, Nonaka I, Ho N, Francomano C, et al. Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia. Am J Hum Genet. 2002;70:1368-75 pubmed
    b>Perlecan, a large heparan sulfate proteoglycan, is a component of the basement membrane and other extracellular matrices and has been implicated in multiple biological functions...
  3. Bix G, Fu J, Gonzalez E, Macro L, Barker A, Campbell S, et al. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol. 2004;166:97-109 pubmed
    Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis...
  4. Gonzalez E, Reed C, Bix G, Fu J, Zhang Y, Gopalakrishnan B, et al. BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J Biol Chem. 2005;280:7080-7 pubmed
    Endorepellin, the C-terminal domain of the heparan sulfate proteoglycan perlecan, possesses angiostatic activity...
  5. Savorè C, Zhang C, Muir C, Liu R, Wyrwa J, Shu J, et al. Perlecan knockdown in metastatic prostate cancer cells reduces heparin-binding growth factor responses in vitro and tumor growth in vivo. Clin Exp Metastasis. 2005;22:377-90 pubmed
    b>Perlecan (Pln) is a major heparan sulfate proteoglycan (HSPG) of extracellular matrices and bone marrow stroma...
  6. Stum M, Davoine C, Vicart S, Guillot Noël L, Topaloglu H, Carod Artal F, et al. Spectrum of HSPG2 (Perlecan) mutations in patients with Schwartz-Jampel syndrome. Hum Mutat. 2006;27:1082-91 pubmed
    ..SJS results from mutations in the HSPG2 gene, which encodes perlecan, a major component of basement membranes. Only eight HSPG2 mutations have been reported in six SJS families...
  7. Arikawa Hirasawa E, Watanabe H, Takami H, Hassell J, Yamada Y. Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999;23:354-8 pubmed
    b>Perlecan, a large, multi-domain, heparan sulfate proteoglycan originally identified in basement membrane, interacts with extracellular matrix proteins, growth factors and receptors, and influences cellular signalling...
  8. Nicole S, Davoine C, Topaloglu H, Cattolico L, Barral D, Beighton P, et al. Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). Nat Genet. 2000;26:480-3 pubmed
    ..Here we describe mutations, including missense and splicing mutations, of the gene encoding perlecan (HSPG2) in three SJS1 families...
  9. Sher I, Zisman Rozen S, Eliahu L, Whitelock J, Maas Szabowski N, Yamada Y, et al. Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation. J Biol Chem. 2006;281:5178-87 pubmed
    ..Here we investigated the role of the heparan sulfate proteoglycan, perlecan, in the formation of human epidermis, by utilizing in vitro engineered human skin...
  10. Cheng F, Syu F, Lee K, Chen F, Wu C, Chen C. Correlation between drug-drug interaction-induced Stevens-Johnson syndrome and related deaths in Taiwan. J Food Drug Anal. 2016;24:427-432 pubmed publisher
    ..To date, there are few reports of incidences of Stevens-Johnson syndrome (SJS) associated with combination drug administration...
  11. Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, et al. Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology. 2018;155:1578-1592.e16 pubmed publisher
    ..Human primary hepatocytes and hepatoma (PLC/PRF/5) cell lines were used to study mechanisms that regulate OATP3A1 expression and transport...
  12. Tajbakhsh A, Pasdar A, Rezaee M, Fazeli M, Soleimanpour S, Hassanian S, et al. The current status and perspectives regarding the clinical implication of intracellular calcium in breast cancer. J Cell Physiol. 2017;: pubmed publisher
    ..homeostasis may cause tumor progression by affecting key factors/pathways including phospholipase C (PLC), inositol 1,4,5-trisphosphate (IP3), calmodulin (CaM), nuclear factor of activated T-cells (NFAT), calpain, ..
  13. Wang C, Lei H, Tian Y, Shang M, Wu Y, Li Y, et al. Clonorchis sinensis granulin: identification, immunolocalization, and function in promoting the metastasis of cholangiocarcinoma and hepatocellular carcinoma. Parasit Vectors. 2017;10:262 pubmed publisher
    ..Stable CsGRN-overexpressed cell lines of hepatoma cells (PLC-GRN cells) and cholangiocarcinoma cells (RBE-GRN cells) were constructed by transfection of eukaryotic expression ..
  14. Finley J. Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1. Med Hypotheses. 2016;93:34-47 pubmed publisher
    ..Upon sperm binding to the oocyte plasma membrane, a sperm-associated phospholipase C (PLC) isoform, PLC zeta (PLC?), is released into the oocyte cytoplasm...
  15. Chen B, Wei W, Ma L, Yang B, Gill R, Chua M, et al. Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. Gastroenterology. 2017;152:2022-2036 pubmed publisher
    ..activity of niclosamide and its ethanolamine salt (NEN) in HCC cell lines (HepG2, Huh7, Hep3B, Hep40, and PLC/PRF/5), primary human hepatocytes, and 2 mouse models of HCC...
  16. Vance D, Dufresne J, Florentinus Mefailoski A, Tucholska M, Trimble W, Grinstein S, et al. A phagocytosis assay for oxidized low-density lipoprotein versus immunoglobulin G-coated microbeads in human U937 macrophages. Anal Biochem. 2016;500:24-34 pubmed publisher
    ..Pharmacological inhibitors of the receptor enzymes JAK, SRC, and PLC prevented both IgG and oxLDL receptor function...
  17. Carraz M, Lavergne C, Jullian V, Wright M, Gairin J, Gonzales de la Cruz M, et al. Antiproliferative activity and phenotypic modification induced by selected Peruvian medicinal plants on human hepatocellular carcinoma Hep3B cells. J Ethnopharmacol. 2015;166:185-99 pubmed publisher
    ..Best extracts were further assessed against other HCC cell lines HepG2, PLC/PRF/5 and SNU-182 and their toxicity measured in vitro on primary human hepatocytes...
  18. Yanashima K, Chieosilapatham P, Yoshimoto E, Okumura K, Ogawa H, Niyonsaba F. Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-ĸB-sensitive pathways. Immunol Res. 2017;65:920-931 pubmed publisher
    ..IDR-1018-induced mast cell activation is mediated through G protein, PLC, MAPK and NF-κB pathways. IDR-1018 will be a useful therapeutic agent for wound healing.
  19. Montalbano R, Honrath B, Wissniowski T, Elxnat M, Roth S, Ocker M, et al. Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells. Oncotarget. 2016;7:20312-23 pubmed publisher
    ..Inhibition of CB1 receptor counteracted BiP expression in transfected Huh-7 and in HBV+ PLC/PRF/5 cells; whereas no effect was observed in HBV- HLF cells...
  20. Mo S, Hou X, Hao X, Cai J, Liu X, Chen W, et al. EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-κB-dependent RAP1 transactivation. Cancer Commun (Lond). 2018;38:9 pubmed publisher
    ..Stable EYA4-expressing plasmid (pEYA4) transfectants of the human HCC cell lines Huh-7 and PLC/PRF/5 (PLC) were established...
  21. Chang Y, Hsu W, Lu W, Jayakumar T, Liao J, Lin M, et al. Inhibitory Mechanisms of CME-1, a Novel Polysaccharide from the Mycelia of Cordyceps sinensis, in Platelet Activation. Curr Pharm Biotechnol. 2015;: pubmed
    ..the ATP-release reaction, relative intracellular [Ca+2] mobilization, and the phosphorylation of phospholipase C (PLC)γ2 and protein kinase C (PKC) stimulated by collagen...
  22. Prysyazhnyuk A, Bazyka D, Romanenko A, Gudzenko N, Fuzik M, Trotsyuk N, et al. Quarter of century since the Chornobyl accident: ?ancer risks in affected groups of population. Probl Radiac Med Radiobiol. 2014;19:147-69 pubmed
    ..uchasti. Oskil'ky latentnyj period dlja riznyh nozologichnyh form radiacijno indukovanyh puhlyn vidriznjajet'sja, u podal'shyh doslidzhennjah slid prydiljaty uvagu ne til'ky zaznachenym formam zlojakisnyh puhlyn, ale j ..
  23. Zhang J, Zhang F, Guo L, Li N, Shan B. Chronic alcohol administration affects purine nucleotide catabolism in vivo. Life Sci. 2017;168:58-64 pubmed publisher
    ..The PLC method was used to detect the absolute content of purine nucleotides in different tissues...
  24. Datta M, Hernandez A, Schlicht M, Kahler A, DeGueme A, Dhir R, et al. Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. Mol Cancer. 2006;5:9 pubmed
    ..We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signaling in Drosophila...
  25. Akimzhanov A, Boehning D. Rapid and transient palmitoylation of the tyrosine kinase Lck mediates Fas signaling. Proc Natl Acad Sci U S A. 2015;112:11876-80 pubmed publisher
    ..Lck palmitoylation kinetics are consistent with the activation of downstream signaling proteins, such as Zap70 and PLC-γ1...
  26. Yoo J, Yang J, Yang H, Cho W, Ma J. Inhibitory effect of fermented Arctium lappa fruit extract on the IgE-mediated allergic response in RBL‑2H3 cells. Int J Mol Med. 2016;37:501-8 pubmed publisher
    ..Lyn, Fyn and Syk, which are involved in the FcεRI signaling pathway, that of phosphoinositide phospholipase C (PLC)γ1/2 and protein kinase C (PKC)δ, which are associated with the degranulation process, as well as that of ..
  27. Pan Y, Zhou C, Yuan D, Zhang J, Shao C. Radiation Exposure Promotes Hepatocarcinoma Cell Invasion through Epithelial Mesenchymal Transition Mediated by H2S/CSE Pathway. Radiat Res. 2016;185:96-105 pubmed publisher
    ..triggering the epithelial mesenchymal transition (EMT) in two hepatocellular carcinoma (HCC) cell lines, HepG2 and PLC/PRF/5...
  28. Zhu Q, Sun L, Lian J, Gao X, Zhao L, Ding M, et al. The phospholipase C (FgPLC1) is involved in regulation of development, pathogenicity, and stress responses in Fusarium graminearum. Fungal Genet Biol. 2016;97:1-9 pubmed publisher
    Phospholipase C (PLC) is an important phospholipid hydrolase that plays critical roles in various biological processes in eukaryotic cells...
  29. Park K, Kim D, Lee B, Ma J. Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line. Mediators Inflamm. 2016;2016:6189590 pubmed
    ..Moreover, KIOM-MA/MA128 suppressed the expression of PLC?1 and PKC...
  30. Leong K, Cheng C, Wong C, Ng I, Kwong Y, Tse E. miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression. Oncotarget. 2017;8:11343-11355 pubmed publisher
    ..Functionally, over-expression of miR-874-3p in HCC cell line PLC/PRF/5 inhibited cell growth and colony formation in-vitro, and promoted cellular apoptosis...
  31. Wang B, Yang G, Liu Q, Qin J, Xu Y, Li W, et al. Inhibitory action of tongue sole LPXRFa, the piscine ortholog of gonadotropin-inhibitory hormone, on the signaling pathway induced by tongue sole kisspeptin in COS-7 cells transfected with their cognate receptors. Peptides. 2017;95:62-67 pubmed publisher
    ..activity, whereas this stimulatory effect was evidently attenuated by two inhibitors of the phospholipase C (PLC)/protein kinase C (PKC) pathway...
  32. Guo Y, Peng Y, Gao D, Zhang M, Yang W, Linghu E, et al. Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma. Clin Epigenetics. 2017;9:116 pubmed publisher
    ..normal liver tissue samples (15), and 13 HCC cell lines (SNU182, SNU449, HBXF344, SMMC7721, Huh7, HepG2, LM3, PLC/PRF/5, BEL7402, SNU387, SNU475, QGY7703, and Huh1) were included in this study...
  33. Yu Y, Hao G, Zhang Q, Hua W, Wang M, Zhou W, et al. Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways. Biochem Pharmacol. 2015;97:173-7 pubmed publisher
    ..We adopted inhibitors of PLC and TRPM5 known to be involved in bitter taste transduction to investigate the underlying pathways mediated in ..
  34. Maekawa K, Nakamura R, Kaniwa N, Mizusawa S, Kitamoto A, Kitamoto T, et al. Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese. Pharmacogenomics. 2015;16:1689-99 pubmed publisher
    ..of HLA-A*31:01, a risk factor for carbamazepine (CBZ) related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). DNAs from Japanese SJS/TEN patients were used for genotyping and developing the assay...
  35. Ramachandren T, Petrilli R. Early toxic epidermal necrolysis syndrome post-intra-cranial tumor resection. Scott Med J. 2016;61:200-202 pubmed
    b>SJS and TEN are two rare self-limited but serious cutaneous drug reactions with significant morbidity and mortality. There are many drugs associated with the condition...
  36. Grindel B, Li Q, Arnold R, Petros J, Zayzafoon M, Muldoon M, et al. Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients. Oncotarget. 2016;7:10433-47 pubmed publisher
    Prostate cancer (PCa) cells use matrix metalloproteinases (MMPs) to degrade tissue during invasion. Perlecan/HSPG2 is degraded at basement membranes, in reactive stroma and in bone marrow during metastasis...
  37. Lu N, Rai S, Terkeltaub R, Kim S, Menendez M, Choi H. Racial disparities in the risk of Stevens-Johnson Syndrome and toxic epidermal necrolysis as urate-lowering drug adverse events in the United States. Semin Arthritis Rheum. 2016;46:253-8 pubmed publisher
    ..varies substantially among races, which may lead to racial disparities in the risk of Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) in the context of urate-lowering drug adverse events (ULDAEs)...
  38. Ichikawa K, Konta T, Sato H, Ueda Y, Yokoyama H. The clinical and pathological characteristics of nephropathies in connective tissue diseases in the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol. 2017;21:1024-1029 pubmed publisher
    ..Our analysis included patients with rheumatoid arthritis (RA) (n?=?52), Sjögren's syndrome (SjS) (n?=?35), scleroderma (n?=?10), mixed connective tissue disease (MCTD; n?=?5), anti-phospholipid syndrome (APS; n?=..
  39. Browning P. The House of Lords debates wound care strategy. J Wound Care. 2017;26:707-711 pubmed publisher
    ..Here, Paul Browning, (Doctoral Research Student, University of Worcester, employed by 3M UK plc) summarises the key points from the evening and explains why it is so important we keep wound care on the ..
  40. Zeng Y, Shen Z, Gu W, Wu M. Inhibition of hepatocellular carcinoma tumorigenesis by curcumin may be associated with CDKN1A and CTGF. Gene. 2018;651:183-193 pubmed publisher
    ..Finally, we detected the expression of CDKN1A, CTGF, LEF1 TF and MIR-19A regulated by curcumin in PLC/PRF/5 cells using RT-PCR. In total, 345 upregulated and 212 downregulated genes were identified...
  41. Stavarachi M, Toma M, Butoianu N, Gavrila L. Preliminary results in a study regarding the relationship between perlecan gene polymorphism and spinal muscular atrophy type I disease. Genet Test Mol Biomarkers. 2009;13:821-4 pubmed publisher
    ..To identify possible modifier genes, the aim of our study was to investigate the relationship between BamH1 perlecan gene polymorphism and SMA type I, the classical severe form of the disease...
  42. Kang Y, Nagaraja A, Armaiz Pena G, Dorniak P, Hu W, Rupaimoole R, et al. Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer. Clin Cancer Res. 2016;22:1713-24 pubmed publisher
    ..analyses indicated that norepinephrine-induced DUSP1 gene expression was mediated through ADRB2 activation of cAMP-PLC-PKC-CREB signaling, which inhibits JNK-mediated phosphorylation of c-Jun and protects ovarian cancer cells from ..
  43. Chidgey J, Fraser P, Aaronson P. Reactive oxygen species facilitate the EDH response in arterioles by potentiating intracellular endothelial Ca(2+) release. Free Radic Biol Med. 2016;97:274-284 pubmed publisher
    ..Inhibiting PLC, PLA2 or CYP450 2C9 each greatly reduced the carbachol-induced increase in EC [Ca(2+)]i and vasodilatation, but ..
  44. Xue G, Romano E, Massi D, Mandala M. Wnt/?-catenin signaling in melanoma: Preclinical rationale and novel therapeutic insights. Cancer Treat Rev. 2016;49:1-12 pubmed publisher
    ..of downstream targets through two independent branches mediated by ?-catenin (defined as canonical pathway) or PLC and small GTPase (defined as non-canonical pathway), respectively...
  45. Tong G, Meng Y, Hao S, Hu S, He Y, Yan W, et al. Parathyroid Hormone Activates Phospholipase C (PLC)-Independent Protein Kinase C Signaling Pathway via Protein Kinase A (PKA)-Dependent Mechanism: A New Defined Signaling Route Would Induce Alternative Consideration to Previous Conceptions. Med Sci Monit. 2017;23:1896-1906 pubmed
    ..to its receptor PTHR1, several signaling pathways, including cAMP/protein kinase A (PKA) and phospholipase C (PLC)/protein kinase C (PKC), are initiated through G proteins; with the cAMP/PKA pathway as the major pathway...
  46. Cabrera Pastor A, Taoro Gonzalez L, López Merino E, Celma F, Llansola M, Felipo V. Chronic hyperammonemia alters in opposite ways membrane expression of GluA1 and GluA2 AMPA receptor subunits in cerebellum. Molecular mechanisms involved. Biochim Biophys Acta Mol Basis Dis. 2018;1864:286-295 pubmed publisher
    ..This leads to increased protein kinase A (PKA) activity which activates phospholipase C (PLC) and protein kinase C (PKC) thus increasing phosphorylation of GluA2 in Ser880, which reduces GluA2 membrane ..
  47. Zhang S, Ni Y, Zhao C, Qiao Z, Yu H, Wang L, et al. Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling. Acta Pharmacol Sin. 2018;39:438-448 pubmed publisher
    ..Treatment with capsaicin alone dose-dependently inhibited the proliferation of the HCC cell lines PLC/PRF/7, HuH7 and HepG2 with IC50 values of 137, 108 and 140.7 μmol/L, respectively...
  48. Wu C, Jin H, Yan Y, Chen J, Wang K, Wang J, et al. Biomechanical Role of the Thoracolumbar Ligaments of the Posterior Ligamentous Complex: A Finite Element Study. World Neurosurg. 2018;112:e125-e133 pubmed publisher
    ..The posterior ligamentous complex (PLC) in the fractured T12-L1 segment was then reduced in a sequential manner from the facet capsular ligament (FCL), ..
  49. Wang J, Yang M, Xiao S, Sun B, Li Y, Yang L. Downregulation of castor zinc finger 1 predicts poor prognosis and facilitates hepatocellular carcinoma progression via MAPK/ERK signaling. J Exp Clin Cancer Res. 2018;37:45 pubmed publisher
    ..and tumor growth and metastasis in vivo, whereas silencing CASZ1 significantly enhanced the above abilities of PLC/PRF/5 cells...
  50. Hopf M, Göhring W, Mann K, Timpl R. Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan. J Mol Biol. 2001;311:529-41 pubmed
    b>Perlecan, a major basement membrane proteoglycan, has a complex modular structure designed for the binding of many cellular and extracellular ligands...
  51. Kvansakul M, Hopf M, Ries A, Timpl R, Hohenester E. Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan. EMBO J. 2001;20:5342-6 pubmed
    Nidogen and perlecan are large multifunctional basement membrane (BM) proteins conserved in all metazoa...
  52. Ravasi P, Braia M, Eberhardt F, Elena C, Cerminati S, Peirú S, et al. High-level production of Bacillus cereus phospholipase C in Corynebacterium glutamicum. J Biotechnol. 2015;216:142-8 pubmed publisher
    Enzymatic oil degumming (removal of phospholipids) using phospholipase C (PLC) is a well-established and environmentally friendly process for vegetable oil refining...
  53. Nicolle D, Fabre M, Simon Coma M, Gorse A, Kappler R, Nonell L, et al. Patient-derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management. Hepatology. 2016;64:1121-35 pubmed publisher
    ..the establishment of an unprecedented preclinical platform of 24 pediatric liver cancer patient-derived xenografts (PLC-PDXs) from 20 hepatoblastomas (HBs), 1 transitional liver cell tumor (TCLT), 1 hepatocellular carcinoma, and 2 ..
  54. Su L, Yang L, Huang S, Su X, Li Y, Wang F, et al. Comparative Gut Microbiomes of Four Species Representing the Higher and the Lower Termites. J Insect Sci. 2016;16: pubmed publisher
    ..8-14%) as the main phyla, and Treponema, TG5, Dysgonomonas, Tannerella, za29, Lactococcus, Pseudomonas, and SJA-88 as the common genera in all the four termites...
  55. Zhang G, Wu X, Xu G, Weng S, Yang X, Zhong Y. Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina. Neuropharmacology. 2018;133:38-50 pubmed publisher
    ..The orexin-B-induced inhibition of GABAC currents was likely mediated by a Gi/o/PC-PLC/Ca2+-independent PKC signaling pathway, as such inhibition was absent when each step of the above-..
  56. D Alessandro R, Refolo M, Lippolis C, Carella N, Messa C, Cavallini A, et al. Strong enhancement by IGF1-R antagonists of hepatocellular carcinoma cell migration inhibition by Sorafenib and/or vitamin K1. Cell Oncol (Dordr). 2018;41:283-296 pubmed publisher
    ..Scratch wound migration assays were performed to assess the motility of HCC-derived PLC/PRF/5, HLF and Hep3B cells...
  57. Lu G, Wu Y, Jiang Y, Wang S, Hou Y, Guan X, et al. Structural insights into neutrophilic migration revealed by the crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1. PLoS ONE. 2013;8:e76219 pubmed publisher
    ..We recently showed that CXCR2 formed a signaling complex with NHERF1 and PLC-2, and that the formation of this complex was required for intracellular calcium mobilization and neutrophilic ..
  58. Wang X, Cao H, Guan X, Long L, Hu Z, Ni L, et al. Sulfite triggers sustained calcium overload in cultured cortical neurons via a redox-dependent mechanism. Toxicol Lett. 2016;258:237-248 pubmed publisher
    ..Pharmacological inhibition of phospholipase C (PLC)-inositol 1,4,5-triphosphate (IP3) signaling pathway blocked sulfite-induced increase of [Ca(2+)]i...
  59. Van Batavia J, Chu D, Long C, Jen M, Canning D, Weiss D. Genitourinary involvement and management in children with Stevens-Johnson syndrome and toxic epidermal necrolysis. J Pediatr Urol. 2017;13:490.e1-490.e7 pubmed publisher
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are devastating hypersensitivity disorders that cause epidermal cell death and can affect all epidermal surfaces, including the urethra, vagina, labial and scrotal skin...
  60. Premshekharan G, Nguyen K, Zhang H, Forman H, Leppert V. Low dose inflammatory potential of silica particles in human-derived THP-1 macrophage cell culture studies - Mechanism and effects of particle size and iron. Chem Biol Interact. 2017;272:160-171 pubmed publisher
    ..scavenger of superoxide and hydrogen peroxide, and an inhibitor of phosphatidylcholine specific phospholipase C (PC-PLC), suppressed the increase in cytokine mRNA expression...
  61. Zheng C, Zou X, Lin H, Zhao B, Zhang M, Luo C, et al. miRNA-185 regulates the VEGFA signaling pathway in dairy cows with retained fetal membranes. Theriogenology. 2018;110:116-121 pubmed publisher
    ..Expression levels of most of the investigated genes (VEGFA, PLC, PRK, RAF, MEK, MAPK, and PLA) were down-regulated in the caruncle tissue of RFM cows...
  62. Williams S, Undieh A. Dopamine-sensitive signaling mediators modulate psychostimulant-induced ultrasonic vocalization behavior in rats. Behav Brain Res. 2016;296:1-6 pubmed publisher
    ..Inhibition of cyclic-AMP/PKA signaling with H89 or inhibition of PLC signaling with U73122 significantly blocked both the acute and subchronic amphetamine-induced USV behavior...
  63. Storch U, Forst A, Pardatscher F, Erdogmus S, Philipp M, Gregoritza M, et al. Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol. Proc Natl Acad Sci U S A. 2017;114:E37-E46 pubmed publisher
    ..the classical transient receptor potential channels TRPC4 and -5 via the Gq/11 protein-phospholipase C (PLC) signaling pathway has remained elusive so far...
  64. Triki Fourati H, Bouaziz M, Benzina M, Bouaziz S. Detection of terrain indices related to soil salinity and mapping salt-affected soils using remote sensing and geostatistical techniques. Environ Monit Assess. 2017;189:177 pubmed publisher
    ..Emission and Reflection Radiometer data to depict geomorphological parameters: elevation, slope, plan curvature (PLC), profile curvature (PRC), and aspect...
  65. Chardonnet S, Bessiron T, Ramos C, Dammak R, Richard M, Boursier C, et al. Native metabotropic glutamate receptor 4 depresses synaptic transmission through an unusual Gαq transduction pathway. Neuropharmacology. 2017;121:247-260 pubmed publisher
    ..First, the Gαq subunit, PLC and PKC signaling proteins present in cerebellar extracts are retained on affinity chromatography columns grafted ..
  66. Abraham G, Dézsi C. The Antihypertensive Efficacy of the Triple Fixed Combination of Perindopril, Indapamide, and Amlodipine: The Results of the PETRA Study. Adv Ther. 2017;34:1753-1763 pubmed publisher
    ..This combination may offer a new therapeutic option for hypertensive patients who have failed to achieve the desired BP target on their previous dual combination therapy. EGIS Pharmaceuticals PLC.
  67. Banan A, Fields J, Zhang Y, Keshavarzian A. Phospholipase C-gamma inhibition prevents EGF protection of intestinal cytoskeleton and barrier against oxidants. Am J Physiol Gastrointest Liver Physiol. 2001;281:G412-23 pubmed
    ..We hypothesized that phospholipase C (PLC)-gamma is required...
  68. Saidi H, Magri G, Nasreddine N, Requena M, Belec L. R5- and X4-HIV-1 use differentially the endometrial epithelial cells HEC-1A to ensure their own spread: implication for mechanisms of sexual transmission. Virology. 2007;358:55-68 pubmed
    ..The removal of heparan sulfate moieties of cell-surface proteoglycans (HSPG) from the apical pole of HEC-1A accounted for at least 60% of both R5- and X4-HIV-1 attachment, showing their ..
  69. Ida Yonemochi H, Ahsan M, Saku T. Differential expression profiles between ?-dystroglycan and integrin ?1 in ameloblastoma: two possible perlecan signalling pathways for cellular growth and differentiation. Histopathology. 2011;58:234-45 pubmed publisher
    Intercellular deposition of perlecan, an extracellular matrix molecule, results in characteristic stellate reticulum-like structures in ameloblastomas...
  70. Morell M, Varela N, Marañon C. Myeloid Populations in Systemic Autoimmune Diseases. Clin Rev Allergy Immunol. 2017;53:198-218 pubmed publisher
    ..RA), primary antiphospholipid antibody syndrome (PAPS), systemic sclerosis (SSc), and Sjögren's syndrome (SjS), based on the data from both mouse preclinical models and patients...
  71. Xuan Z, Zhou L, Wang Y, Zheng X. Prognostic value of the combination of serum levels of vascular endothelial growth factor, C-reactive protein and contrast-enhanced ultrasound in patients with primary liver cancer who underwent transcatheter arterial chemoembolization. Expert Rev Anticancer Ther. 2017;17:1169-1178 pubmed publisher
    ..of serum levels of vascular endothelial growth factor (VEGF), C-reactive protein (CRP), and contrast-enhanced ultrasound (CEUS) in patients with primary liver cancer (PLC) after transcatheter arterial chemoembolization (TACE).
  72. Mongiat M, Fu J, Oldershaw R, Greenhalgh R, Gown A, Iozzo R. Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. J Biol Chem. 2003;278:17491-9 pubmed
    The goal of this study was to discover novel partners for perlecan, a major heparan sulfate proteoglycan of basement membranes, and to examine new interactions through which perlecan may influence cell behavior...
  73. Chen G, Ding J, Luo L, Liu Y, Yan K, Chen P, et al. [Expression of perlecan in laryngeal carcinoma cell and its significance]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006;20:78-80 pubmed
    To study the expression of perlecan in human laryngeal carcinoma cells and its significance. The expression of perlecan mRNA in human laryngeal carcinoma cells, Hep-2 cells were investigated by using the techniques of semi-quantify RT-PCR...
  74. Cao Z, Maupin K, Curnutte B, Fallon B, Feasley C, Brouhard E, et al. Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from nonmucinous pancreatic cysts. Mol Cell Proteomics. 2013;12:2724-34 pubmed publisher
    ..The results show that MUC5AC and endorepellin glycoforms may be highly specific and sensitive biomarkers for the differentiation of mucinous from nonmucinous pancreatic cysts. ..
  75. Kurnaz Gömleksiz Ö, Tokat B, Aslan E, Yanar F, Ermiş Karaali Z, Ozturk O, et al. Can rs3767140 SNP of the perlecan (HSPG2) gene affect the diabetes mellitus through the dyslipidemia?. Cell Mol Biol (Noisy-le-grand). 2016;62:35-9 pubmed
    b>Perlecan (HSPG2) play an important role in the lipoprotein metabolisms. The G allele of the HSPG2-rs3767140 may affect the binding of heparan sulfate (HS) chains and hence cause loss of HS from the basement membrane...
  76. Nagashima S, Takahashi M, Kobayashi T, Nishizawa T, Nishiyama T, Primadharsini P, et al. Characterization of the Quasi-Enveloped Hepatitis E Virus Particles Released by the Cellular Exosomal Pathway. J Virol. 2017;91: pubmed publisher
    ..In this study, we characterized exosomes purified from the culture supernatants of HEV-infected PLC/PRF/5 cells...
  77. Lv M, Zhou Y, Chen X, Han L, Wang L, Lu X. Calcium signaling of in situ chondrocytes in articular cartilage under compressive loading: Roles of calcium sources and cell membrane ion channels. J Orthop Res. 2017;: pubmed publisher
    ..Depletion of intracellular Ca2+ stores, inhibition of PLC-IP3 pathway, and block of purinergic receptors on plasma membrane led to significant reduction in the ..
  78. Tomasella M, Häberle K, Nardini A, Hesse B, Machlet A, Matyssek R. Post-drought hydraulic recovery is accompanied by non-structural carbohydrate depletion in the stem wood of Norway spruce saplings. Sci Rep. 2017;7:14308 pubmed publisher
    ..During the second cycle, stem percent loss of hydraulic conductivity (PLC) and NSC content showed no carry-over effects from the previous drought, indicating complete long-term recovery...
  79. Gu S, Hsieh Y, Lin P. Signaling involved in PTTH-stimulated 4E-BP phosphorylation in prothoracic gland cells of Bombyx mori. J Insect Physiol. 2017;96:1-8 pubmed publisher
    ..In addition, we found that a potent and specific inhibitor of phospholipase C (PLC), U73122, greatly inhibited 4E-BP phosphorylation...
  80. Tomizawa K, Nishino M, Sesumi Y, Kobayashi Y, Sato K, Chiba M, et al. Prognostic impact of pleural lavage cytology in patients with primary lung cancer. Lung Cancer. 2016;102:60-64 pubmed publisher
    Positive pleural lavage cytology (PLC) has been reported to have a negative prognostic impact in patients with surgically resected non-small cell lung cancer (NSCLC)...
  81. Whitaker L, Warren B, Venniro M, Harte T, McPherson K, Beidel J, et al. Bidirectional Modulation of Intrinsic Excitability in Rat Prelimbic Cortex Neuronal Ensembles and Non-Ensembles after Operant Learning. J Neurosci. 2017;37:8845-8856 pubmed publisher
    ..Here, we use the Fos promoter to identify strongly activated neuronal ensembles in rat prelimbic cortex (PLC) and assess altered intrinsic excitability after 10 d of operant food self-administration training (1 h/d)...
  82. Ntostis P, Carter D, Iles D, Huntriss J, Tzetis M, Miller D. Potential sperm contributions to the murine zygote predicted by in silico analysis. Reproduction. 2017;154:777-788 pubmed publisher
    ..In addition, sperm-egg fusion activates several downstream processes that contribute to zygote formation, including PLC zeta-mediated egg activation and maternal RNA clearance...
  83. Flori E, Rosati E, Cardinali G, Kovacs D, Bellei B, Picardo M, et al. The ?-melanocyte stimulating hormone/peroxisome proliferator activated receptor-? pathway down-regulates proliferation in melanoma cell lines. J Exp Clin Cancer Res. 2017;36:142 pubmed publisher
    ..This effect was independent of the cAMP/PKA pathway and was mediated by the activation of the PI(4,5)P2/PLC pathway, a pathway which we have described to be triggered by the ?MSH-dependent MC1R stimulation...
  84. McCormick N, Marra C, Aviña Zubieta J. Productivity Losses and Costs in the Less-Common Systemic Autoimmune Rheumatic Diseases. Curr Rheumatol Rep. 2017;19:72 pubmed publisher
    ..on productivity losses and costs in the less-common systemic autoimmune rheumatic diseases: Sjogren's syndrome (SjS), systemic sclerosis (SSc), poly/dermatomyositis (PM/DM), and systemic vasculitides (SV)...
  85. Okamoto Uchida Y, Nakamura R, Matsunaga K, Aihara M, Saito Y. Specific association of the rs6500265 and rs9933632 single-nucleotide polymorphisms in Japanese patients with antipyretic analgesic-related Stevens-Johnson syndrome and toxic epidermal necrolysis with severe ocular involvements. Pharmacogenet Genomics. 2018;28:95-98 pubmed publisher
    ..genome-wide imputation showed the association of several SNPs with cold medicine-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications...
  86. Gonzalez E, Mongiat M, Slater S, Baffa R, Iozzo R. A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth. J Biol Chem. 2003;278:38113-6 pubmed
    In an in vivo search of novel partners for perlecan, a major heparan sulfate proteoglycan of basement membranes and cell surfaces, we identified progranulin, a secreted growth factor, as a strong interacting protein...
  87. Gnoatto N, Lotufo R, Toffoletto O, Marquezini M. Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth. J Periodontol. 2003;74:1747-53 pubmed
    ..mRNA expression of the proteoglycans perlecan, decorin, biglycan, and versican was analyzed by reverse transcription polymerase chain reaction (RT-PCR) in ..
  88. Suzuki A, Ji G, Numabe Y, Muramatsu M, Gomi K, Kanazashi M, et al. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. Biochem Biophys Res Commun. 2004;317:887-92 pubmed
    ..These appear to be good candidates as genetic factors for future study. ..
  89. Argyris E, Kulkosky J, Meyer M, Xu Y, Mukhtar M, Pomerantz R, et al. The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity. Virology. 2004;330:481-6 pubmed
    ..Herein, we report that human WiDr cells, which express perlecan but no other HSPGs, can internalize 125I-labeled Tat with minimal lysosomal degradation...
  90. Wang B, Jin F, Yang Z, Lu Z, Zheng C, Wang L. HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese. Dement Geriatr Cogn Disord. 2007;23:312-5 pubmed
    ..Likewise with the stratification of APOE epsilon4 status, no statistical difference was observed between cases and controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD. ..
  91. Greenbaum L, Alkelai A, Zozulinsky P, Kohn Y, Lerer B. Support for association of HSPG2 with tardive dyskinesia in Caucasian populations. Pharmacogenomics J. 2012;12:513-20 pubmed publisher
    ..03). Although the associations were only nominally significant, the findings provide further support for the possible involvement of HSPG2 in susceptibility to TD. ..
  92. Hall S, Ward R. Septate Junction Proteins Play Essential Roles in Morphogenesis Throughout Embryonic Development in Drosophila. G3 (Bethesda). 2016;6:2375-84 pubmed publisher
    ..More than 20 genes have been identified to function in the establishment or maintenance of SJs in Drosophila melanogaster Numerous studies have demonstrated the cell biological function of these proteins in ..