pericentrin

Summary

Gene Symbol: pericentrin
Description: pericentrin
Alias: KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin, kendrin, pericentrin-2, pericentrin-380, pericentrin-B
Species: human
Products:     pericentrin

Top Publications

  1. Diviani D, Langeberg L, Doxsey S, Scott J. Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain. Curr Biol. 2000;10:417-20 pubmed
    ..Here, we show that pericentrin, an integral component of the pericentriolar matrix of the centrosome that has been shown to regulate ..
  2. Li Q, Hansen D, Killilea A, Joshi H, Palazzo R, Balczon R. Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1. J Cell Sci. 2001;114:797-809 pubmed
    ..The N-terminal region of the protein, named pericentrin-B, shares 61% identity (75% similarity) with pericentrin, suggesting an evolutionary relationship between these ..
  3. Jurczyk A, Gromley A, Redick S, San Agustin J, Witman G, Pazour G, et al. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. J Cell Biol. 2004;166:637-43 pubmed
    ..Here, we show that the centrosome protein pericentrin (Pcnt) colocalizes with IFT proteins to the base of primary and motile cilia...
  4. Griffith E, Walker S, Martin C, Vagnarelli P, Stiff T, Vernay B, et al. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet. 2008;40:232-6 pubmed
    ..We now report that mutations in the gene encoding pericentrin (PCNT)--resulting in the loss of pericentrin from the centrosome, where it has key functions anchoring both ..
  5. Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, et al. Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:967-76 pubmed publisher
    ..Previously, we identified pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ) as binding partners of DISC1; further, we observed ..
  6. Haren L, Stearns T, Lüders J. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. PLoS ONE. 2009;4:e5976 pubmed publisher
    ..the recruitment of other PCM proteins implicated in centrosomal gamma-tubulin attachment (Cep192/hSPD2, pericentrin, Cep215/Cdk5Rap2)...
  7. Wang Z, Wu T, Shi L, Zhang L, Zheng W, Qu J, et al. Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. J Biol Chem. 2010;285:22658-65 pubmed publisher
    ..Furthermore, the CM2-like motif is essential for the association of the centrosome-targeting domain to pericentrin and AKAP450...
  8. Lee K, Rhee K. PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis. J Cell Biol. 2011;195:1093-101 pubmed publisher
    ..It is known that PLK1 is critical for the initiation of centrosome maturation. In this paper, we report that pericentrin (PCNT), a PCM protein, was specifically phosphorylated by PLK1 during mitosis...
  9. Flory M, Moser M, Monnat R, Davis T. Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin. Proc Natl Acad Sci U S A. 2000;97:5919-23 pubmed
    ..N-terminal regions of kendrin share significant sequence homology with pericentrin, a previously identified murine centrosome component known to interact with gamma-tubulin...

More Information

Publications118 found, 100 shown here

  1. Flory M, Davis T. The centrosomal proteins pericentrin and kendrin are encoded by alternatively spliced products of one gene. Genomics. 2003;82:401-5 pubmed
    b>Pericentrin, a critical centrosome component first identified in mouse, recruits factors required for assembly of the mitotic spindle apparatus...
  2. Miyoshi K, Asanuma M, Miyazaki I, Diaz Corrales F, Katayama T, Tohyama M, et al. DISC1 localizes to the centrosome by binding to kendrin. Biochem Biophys Res Commun. 2004;317:1195-9 pubmed
    ..One of the positive clones encoded kendrin/pericentrin-B, a giant protein known to localize specifically to the centrosome...
  3. Rauch A, Thiel C, Schindler D, Wick U, Crow Y, Ekici A, et al. Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science. 2008;319:816-9 pubmed publisher
    ..Using genetic linkage analysis, we find that biallelic loss-of-function mutations in the centrosomal pericentrin (PCNT) gene on chromosome 21q22...
  4. Numata S, Iga J, Nakataki M, Tayoshi S, Tanahashi T, Itakura M, et al. Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population. J Psychiatry Neurosci. 2009;34:195-8 pubmed
    b>Pericentrin (PCNT) interacts with disruption-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD)...
  5. Willems M, Genevieve D, Borck G, Baumann C, Baujat G, Bieth E, et al. Molecular analysis of pericentrin gene (PCNT) in a series of 24 Seckel/microcephalic osteodysplastic primordial dwarfism type II (MOPD II) families. J Med Genet. 2010;47:797-802 pubmed publisher
    ..In 2008, loss-of-function mutations in the pericentrin gene (PCNT) have been identified in 28 patients, including 3 SCKL and 25 MOPDII cases...
  6. Jurczyk A, Pino S, O Sullivan Murphy B, Addorio M, Lidstone E, Diiorio P, et al. A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS ONE. 2010;5:e11812 pubmed publisher
    ..Recently, mutations in the centrosomal protein, pericentrin, have been linked to human microcephalic osteodysplastic primordial dwarfism (MOPD II), a rare genetic disease ..
  7. Stiborova M, Cechova T, Bořek Dohalská L, Moserova M, Frei E, Schmeiser H, et al. Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes. Neuro Endocrinol Lett. 2012;33 Suppl 3:8-15 pubmed
    ..pretreated with Sudan I, β-naphthoflavone (β-NF), phenobarbital (PB), ethanol and pregnenolon 16α-carbonitrile (PCN), the inducers of cytochromes P450 (CYP) 1A1, 1A1/2, 2B, 2E1 and 3A, respectively, were used in this study...
  8. Dempsey J, Cui J. Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver. Drug Metab Dispos. 2019;47:329-339 pubmed publisher
    ..lncRNAs, RNA-Seq was performed from livers of adult male C57BL/6 mice treated with corn oil, the PXR agonist PCN, or the CAR agonist 1, 4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP)...
  9. Mossine V, Chance D, Waters J, Mawhinney T. Interaction of Bacterial Phenazines with Colistimethate in Bronchial Epithelial Cells. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..toxins, pyocyanin (PYO), 1-hydroxyphenazine (1-HP), phenazine-1-carboxylic acid (PCA), and phenazine-1-carboxamide (PCN), and two commonly prescribed polymyxin drugs, colistin-colistimethate sodium (CMS) and polymyxin B, in three human ..
  10. Costa K, Bergkessel M, Saunders S, Korlach J, Newman D. Enzymatic Degradation of Phenazines Can Generate Energy and Protect Sensitive Organisms from Toxicity. MBio. 2015;6:e01520-15 pubmed publisher
    ..degradation of three Pseudomonas-derived phenazines: phenazine-1-carboxylic acid (PCA), phenazine-1-carboxamide (PCN), and pyocyanin (PYO). PCA can be used as the sole carbon source for growth by these organisms...
  11. Chen J, Segni M, Payne F, Huang Doran I, Sleigh A, Adams C, et al. Truncation of POC1A associated with short stature and extreme insulin resistance. J Mol Endocrinol. 2015;55:147-58 pubmed publisher
    ..Further investigation of links between these molecular defects and adipose tissue dysfunction is likely to yield insights into mechanisms of adipose tissue maintenance and regeneration that are critical to metabolic health. ..
  12. McIntyre R, Lakshminarasimhan Chavali P, Ismail O, Carragher D, Sanchez Andrade G, Forment J, et al. Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. PLoS Genet. 2012;8:e1003022 pubmed publisher
    Disruption of the centromere protein J gene, CENPJ (CPAP, MCPH6, SCKL4), which is a highly conserved and ubiquitiously expressed centrosomal protein, has been associated with primary microcephaly and the microcephalic primordial dwarfism ..
  13. Jeffries J, Jia J, Choi W, Choe S, Miao J, Xu Y, et al. Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis(x) to increase binding to airway epithelial cells. Mucosal Immunol. 2016;9:1039-1050 pubmed publisher
    ..We found pyocyanin (PCN) to be a potent inducer of sialyl-Lewis(x) in both mouse airways and in primary and immortalized CF and non-CF ..
  14. Hassani Nezhad Gashti F, Rysa J, Kummu O, Näpänkangas J, Buler M, Karpale M, et al. Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver. Biochem Pharmacol. 2018;148:253-264 pubmed publisher
    ..PXR ligand pregnenolone-16ɑ-carbonitrile (PCN) impaired glucose tolerance in the wildtype mice but not in the PXR knockout mice...
  15. Virreira Winter S, Zychlinsky A. The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species. J Biol Chem. 2018;293:4893-4900 pubmed publisher
    ..The phenazine pyocyanin (PCN) is a virulence factor of Pseudomonas aeruginosa and generates superoxide in cells...
  16. Rashid M, Ali A, Andleeb S. Functional Annotation and Analysis of Dual Oxidase 1 (DUOX1): a Potential Anti-pyocyanin Immune Component. Interdiscip Sci. 2018;: pubmed publisher
    ..Both the host and pathogen enter a redox dual with DUOX1 and hypothiocyanite from host and Pyocyanin (PCN) as a redox active virulence factor from P. aeruginosa...
  17. Patel D, Rathinam M, Jarvis C, Mahimainathan L, Henderson G, Narasimhan M. Role for Cystathionine ? Lyase (CSE) in an Ethanol (E)-Induced Lesion in Fetal Brain GSH Homeostasis. Int J Mol Sci. 2018;19: pubmed publisher
    ..This was associated with a significant reduction in cystathionine ?-lyase (CSE) protein expression in PCN (p < 0.05) and in fetal cerebral cortex in utero (53%, p < 0...
  18. Santos Lopez A, Bernabe Balas C, Ares Arroyo M, Ortega Huedo R, Hoefer A, San Millan A, et al. A Naturally Occurring Single Nucleotide Polymorphism in a Multicopy Plasmid Produces a Reversible Increase in Antibiotic Resistance. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..This coexistence produced an increase of the total plasmid copy number (PCN) in the host bacteria, leading to a rise in both the antibiotic resistance level and the metabolic burden produced ..
  19. Garg A, Zhao A, Erickson S, Mukherjee S, Lau A, Alston L, et al. Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation. J Pharmacol Exp Ther. 2016;359:91-101 pubmed publisher
    ..In vivo, activation of the PXR [pregnenolone 16α-carbonitrile (PCN)] attenuated barrier disruption induced by toll-like receptor 4 activation in wild-type, but not Pxr-/-, mice...
  20. Antolino Lobo I, Meulenbelt J, Nijmeijer S, Maas Bakker R, Meijerman I, van den Berg M, et al. 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition. Toxicol Lett. 2011;203:82-91 pubmed publisher
    ..hepatocytes that were pretreated with or without the rodent PXR activator pregnenolone 16alpha-carbonitrile (PCN), MDMA inhibited CYP3A catalytic activity with IC₅₀ values of 0.06 ± 0.12 and 0.09 ± 0...
  21. Liu K, Joshi V, van Camp L, Yang Q, Baars J, Strasser S, et al. Prevalence and outcomes of pancreatic cystic neoplasms in liver transplant recipients. World J Gastroenterol. 2017;23:8526-8532 pubmed publisher
    ..03) compared to patients without pancreatic cysts. Thirteen patients (42%) were diagnosed with PCN pre-LT while 18 patients (58%) developed PCN post-LT...
  22. Bauer B, Hartz A, Lucking J, Yang X, Pollack G, Miller D. Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier. J Cereb Blood Flow Metab. 2008;28:1222-34 pubmed publisher
    ..drug efflux transporter, P-glycoprotein, in capillaries exposed to PXR ligands (pregnenolone-16alpha-carbonitrile (PCN) and dexamethasone) in vitro and in vivo...
  23. Cui H, Gu X, Chen J, Xie Y, Ke S, Wu J, et al. Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[?]-pyrene-induced DNA damage. Toxicol Lett. 2017;275:67-76 pubmed publisher
    ..Using PXR-null and wild type mouse hepatocytes we showed that PXR activation by pregnenolone 16?-carbonitrile (PCN) significantly inhibited BaP-induced DNA damage and this protective effect was abolished in PXR-null hepatocytes...
  24. Zheng M, Li C, Liu S, Gui M, Ni J. Potential application of aerobic denitrifying bacterium Pseudomonas aeruginosa PCN-2 in nitrogen oxides (NOx) removal from flue gas. J Hazard Mater. 2016;318:571-578 pubmed publisher
    ..for NOx removal at varying oxygen levels using the newly isolated bacterial strain Pseudomonas aeruginosa PCN-2 which was capable of aerobic and anoxic denitrification...
  25. Hukkanen J, Rysa J, Mäkelä K, Herzig K, Hakkola J, Savolainen M. The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humans. J Physiol Pharmacol. 2015;66:831-9 pubmed
    ..and insulin were analysed in previously collected rat OGTT samples after pregnenolone 16α-carbonitrile (PCN) or control treatment for 4 days...
  26. Patodia M, Goel A, Singh V, Singh B, Sinha R, Kumar M, et al. Are there any predictors of pyonephrosis in patients with renal calculus disease?. Urolithiasis. 2017;45:415-420 pubmed publisher
    ..All patients of RCD who had undergone either percutaneous nephrostomy (PCN) or surgical management (percutaneous nephrolithotomy/pyelolithotomy/nephrectomy) were included...
  27. Morales Caselles C, Desforges J, Dangerfield N, Ross P. A Risk-Based Characterization of Sediment Contamination by Legacy and Emergent Contaminants of Concern in Coastal British Columbia, Canada. Arch Environ Contam Toxicol. 2017;73:270-284 pubmed publisher
    ..contaminant classes detected in sediments were ?PCB > ?PBDE > ?PCDD/F > DDT > ?HBCDD > ?PCN. Near-urban harbor sediments had up to three orders of magnitude higher concentrations of contaminants than more ..
  28. Zhou L, Jiang H, Sun S, Yang D, Jin K, Zhang W, et al. Biotechnological potential of a rhizosphere Pseudomonas aeruginosa strain producing phenazine-1-carboxylic acid and phenazine-1-carboxamide. World J Microbiol Biotechnol. 2016;32:50 pubmed publisher
    ..In addition, PA1201 produced another antifungal metabolite, phenazine-1-carboxaminde (PCN), a derivative of PCA, with the fermentation titers of 18.1 and 489.5 mg/L in PPM and SCG medium respectively...
  29. Newton L, Kotowski A, Grinker M, Chun R. Diagnosis and management of pediatric sinusitis: A survey of primary care, otolaryngology and urgent care providers. Int J Pediatr Otorhinolaryngol. 2018;108:163-167 pubmed publisher
    ..ENT providers will also use clarithromycin and Bactrim more often compared to PCPs. For PCN allergy patients, most providers choose cefdinir...
  30. Ma W, Viveiros M. Depletion of pericentrin in mouse oocytes disrupts microtubule organizing center function and meiotic spindle organization. Mol Reprod Dev. 2014;81:1019-29 pubmed publisher
    ..and function of acentriolar MTOCs in mouse oocytes, we assessed the role of a key MTOC-associated protein, pericentrin (PCNT)...
  31. Sarwar A, Zhou L, Chakrala N, Brook O, Weinstein J, Rosen M, et al. The Relevance of Readmissions after Common IR Procedures: Readmission Rates and Association with Early Mortality. J Vasc Interv Radiol. 2017;28:629-636 pubmed publisher
    ..001), IVC filter (AOR 2.98; 95% CI, 1.3-6.9; P = .01), PLB (AOR 2.86; 95% CI, 1.71-4.79; P < .001), and PCN (AOR 3.09; 95% CI, 1.29-7.37; P = .01) were associated with 90-day mortality...
  32. Preston K, Hitchcock S, Aziz A, Tine J. The complete nucleotide sequence of the multi-drug resistance-encoding IncL/M plasmid pACM1. Plasmid. 2014;76:54-65 pubmed publisher
    ..Since resistance gene dosage is affected by plasmid copy number (PCN), we used a relatively simple new "efficiency-corrected" qPCR assay to measure the PCN of pACM1...
  33. Kukučka P, Audy O, Kohoutek J, Holt E, Kalábová T, Holoubek I, et al. Source identification, spatio-temporal distribution and ecological risk of persistent organic pollutants in sediments from the upper Danube catchment. Chemosphere. 2015;138:777-83 pubmed publisher
    ..Concentrations expressed as toxic equivalents (TEQs), for PCDD/F+dl-PCB+PCN (TEQPCDD/F+dl-PCB+PCN) ranged from 0.37 to 19 pg g(-1)...
  34. Boland A, Martin T, Zhang Z, Yang J, Bai X, Chang L, et al. Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution. Nat Struct Mol Biol. 2017;24:414-418 pubmed publisher
    ..Scc1 and Rec8) of cohesin, and regulates centrosome duplication and mitotic spindle function through cleavage of kendrin and Slk19...
  35. Stewart J, Smith T, Kim C. Clinical implications of acute pelvicaliceal hematoma formation during percutaneous catheter nephrostomy insertion. Clin Imaging. 2017;43:180-183 pubmed publisher
    ..the clinical implications of acute pelvicaliceal hematoma formation during percutaneous catheter nephrostomy (PCN) insertion. Collecting system hematoma burden was retrospectively assessed for 694 PCN insertions in 502 patients...
  36. Ahmadi S, Slotty P, Munoz Bendix C, Steiger H, Cornelius J. Early surgical occipitocervical stabilization for plasma cell neoplasms at the craniocervical junction: systematic review and proposal of a treatment algorithm. Spine J. 2016;16:91-104 pubmed publisher
    ..Therefore, PCNs at the CCJ require special consideration. Although the commonly used primary treatment of PCN is radiotherapy (RT), treatment guidelines are inexistent for CCJ occurrences...
  37. Iesato Y, Imai A, Hirano T, Toriyama Y, Murata T. Effect of leaking capillaries and microaneurysms in the perifoveal capillary network on resolution of macular edema by anti-vascular endothelial growth factor treatment. Jpn J Ophthalmol. 2016;60:86-94 pubmed publisher
    To investigate the effect of leaking capillaries and microaneurysms (MAs) in the perifoveal capillary network (PCN) on the treatment of fovea-involving macular edema (ME) secondary to branch retinal vein occlusion (BRVO) by intravitreal ..
  38. Wozniak L, Soprovich A, Rees S, Johnson S, Majumdar S, Johnson J. A qualitative study examining healthcare managers and providers' perspectives on participating in primary care implementation research. BMC Health Serv Res. 2016;16:316 pubmed publisher
    ..We conducted 34 in-person or telephone interviews with 17 individual PCN professionals. We used content analysis to identify emerging codes and concepts...
  39. Ma Z, Hua G, Ongena M, Hofte M. Role of phenazines and cyclic lipopeptides produced by pseudomonas sp. CMR12a in induced systemic resistance on rice and bean. Environ Microbiol Rep. 2016;: pubmed publisher
    ..completely lost their ability to induce systemic resistance, while a soil drench with pure phenazine-1-carboxamide (PCN) at a concentration of 0.1 or 1 ?M was active in inducing resistance against M. oryzae...
  40. Netsch C, Becker B, Gross A. [Management of ureteral obstruction : Value of percutaneous nephrostomy and ureteral stents]. Urologe A. 2016;55:1497-1510 pubmed
    ..represents a heterogeneous disease pattern and is treated by ureteral stenting or percutaneous nephrostomy (PCN) depending on the necessity...
  41. Medley J, DeMeyer L, Kabara M, Song M. APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans. G3 (Bethesda). 2017;7:3937-3946 pubmed publisher
    ..Our data suggest that the APC/CFZR-1 regulates SAS-5 levels by directly recognizing the conserved KEN-box motif, contributing to proper centrosome duplication...
  42. Huang Y, Li J, Xu Y, Xu W, Zhong G, Liu X, et al. Polychlorinated naphthalenes in the air over the equatorial Indian Ocean: Occurrence, potential sources, and toxicity. Mar Pollut Bull. 2016;107:240-244 pubmed publisher
    ..b>PCN concentration of these air samples ranged from 0.033 to 2.56pgm(-3), with an average of 0...
  43. Ma G, Goldberg D, Thiruvengadam N, Chandrasekhara V, Kochman M, Ginsberg G, et al. Comparing American Gastroenterological Association Pancreatic Cyst Management Guidelines with Fukuoka Consensus Guidelines as Predictors of Advanced Neoplasia in Patients with Suspected Pancreatic Cystic Neoplasms. J Am Coll Surg. 2016;223:729-737.e1 pubmed publisher
    ..We performed a retrospective study of 239 patients who underwent surgical resection for suspected mucinous PCN at a tertiary care center from 2000 to 2014. Surgical pathology was the gold standard...
  44. Wu J, Hu J, Wang S, Jin J, Wang R, Wang Y, et al. Levels, sources, and potential human health risks of PCNs, PCDD/Fs, and PCBs in an industrial area of Shandong Province, China. Chemosphere. 2018;199:382-389 pubmed publisher
    ..The PCN, PCDD/F, and PCB levels in these samples were determined...
  45. Shimizu S, Matsuzaki S, Hattori T, Kumamoto N, Miyoshi K, Katayama T, et al. DISC1-kendrin interaction is involved in centrosomal microtubule network formation. Biochem Biophys Res Commun. 2008;377:1051-6 pubmed publisher
    ..We previously identified 446-533 amino acids of DISC1 as the kendrin-binding region by means of a directed yeast two-hybrid interaction assay and showed that the DISC1-kendrin ..
  46. Zhang L, Zhang L, Dong L, Huang Y, Li X. Concentrations and patterns of polychlorinated naphthalenes in surface sediment samples from Wuxi, Suzhou, and Nantong, in East China. Chemosphere. 2015;138:668-74 pubmed publisher
    ..The total PCN (tri- to octachlorinated naphthalenes) concentrations in the samples from Wuxi, Suzhou, and Nantong were 0.89-40, 2...
  47. Kucharski T, Minshall P, Moustafa Kamal M, Turnell A, Teodoro J. Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress. Cell Rep. 2017;18:1982-1995 pubmed publisher
    ..Here, we show that the DNA damage response protein 53BP1 contains conserved KEN boxes that are required for APC/C-dependent degradation in early mitosis...
  48. Duceppe M, Lafond Lapalme J, Palomares Rius J, Sabeh M, Blok V, Moffett P, et al. Analysis of survival and hatching transcriptomes from potato cyst nematodes, Globodera rostochiensis and G. pallida. Sci Rep. 2017;7:3882 pubmed publisher
    ..Here, we have studied the progression of PCN transcriptomes from dry cysts to hatched juveniles using RNA-Seq...
  49. Pang J, Yuan S, Du D, Lollar C, Zhang L, Wu M, et al. Flexible Zirconium MOFs as Bromine-Nanocontainers for Bromination Reactions under Ambient Conditions. Angew Chem Int Ed Engl. 2017;56:14622-14626 pubmed publisher
    A series of flexible MOFs (PCN-605, PCN-606, and PCN-700) are synthesized and applied to reversible bromine encapsulation and release...
  50. Peng H, Ouyang Y, Bilal M, Wang W, Hu H, Zhang X. Identification, synthesis and regulatory function of the N-acylated homoserine lactone signals produced by Pseudomonas chlororaphis HT66. Microb Cell Fact. 2018;17:9 pubmed publisher
    ..the rice rhizosphere is an important plant growth-promoting rhizobacteria that produce phenazine-1-carboxamide (PCN) in high yield...
  51. Li S, Liu G, Zheng M, Liu W, Li J, Wang M, et al. Unintentional production of persistent chlorinated and brominated organic pollutants during iron ore sintering processes. J Hazard Mater. 2017;331:63-70 pubmed publisher
    ..The PCDD/F, PCB, PCN, PBDD/F, and PBDE emission factors were 2.47, 0.61, 552, 0.32, and 107?gt-1, respectively (109, 4.07, 10...
  52. Gewurtz S, Gandhi N, Drouillard K, Kolic T, MacPherson K, Reiner E, et al. Levels, patterns, trends and significance of polychlorinated naphthalenes (PCNs) in Great Lakes fish. Sci Total Environ. 2018;624:499-508 pubmed publisher
    ..A limited comparison of fillet and wholebody concentrations in Carp and Bullhead was also conducted. The ?PCN ranged from 0.006-6.7ng/g wet weight (ww) and 0...
  53. Davies A, Barrett I, Pambid M, Hu K, Stratford A, Freeman S, et al. YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification. Oncogene. 2011;30:3649-60 pubmed publisher
    ..revealed that YB-1 localized to the centrosome in a phosphorylation-dependent manner, where it complexed with pericentrin and ?-tubulin...
  54. Marinho J, da Silva J, Ferreira M. [Health education as a transversal proposal: an analysis of the national curriculum guidelines and certain teaching conceptions]. Hist Cienc Saude Manguinhos. 2015;22:429-44 pubmed publisher
    ..The analysis is founded on the transversal subject of "health" in the national curriculum guidelines (PCN), on semi-structured interviews and on reports resulting from conversations with teachers...
  55. Gao Q, Cieplik M, Budarin V, Gronnow M, Jansson S. Mechanistic evaluation of polychlorinated dibenzo-p-dioxin, dibenzofuran and naphthalene isomer fingerprints in microwave pyrolysis of biomass. Chemosphere. 2016;150:168-175 pubmed publisher
    ..The PCN isomer distributions showed a tendency for sequential chlorination from non-substituted naphthalene at successive ..
  56. Dat N, Chang K, Chang M. Characteristics of atmospheric polychlorinated naphthalenes (PCNs) collected at different sites in northern Taiwan. Environ Pollut. 2018;237:186-195 pubmed publisher
    ..at three sites in northern Taiwan using high-volume samplers during winter and summer to evaluate the atmospheric PCN characteristics including concentration, distribution, potential sources and gas/particle partitioning...
  57. Shizu R, Abe T, Benoki S, Takahashi M, Kodama S, Miayata M, et al. PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor. Biochem J. 2016;473:257-66 pubmed publisher
    ..this growth was augmented by the expression of mouse PXR and co-treatment with pregnenolone 16α-carbonitrile (PCN), a PXR ligand...
  58. Gao L, Zhang Y, Wang Y, Qiao X, Zi J, Chen C, et al. Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa. Redox Biol. 2016;8:252-8 pubmed publisher
    Pyocyanin (PCN), a virulence factor synthesized by Pseudomonas aeruginosa, plays an important role during clinical infections. There is no study of the effect of nitric oxide (NO) on PCN biosynthesis...
  59. Ali U, Sánchez García L, Rehman M, Syed J, Mahmood A, Li J, et al. Tracking the fingerprints and combined TOC-black carbon mediated soil-air partitioning of polychlorinated naphthalenes (PCNs) in the Indus River Basin of Pakistan. Environ Pollut. 2016;208:850-8 pubmed publisher
    ..4E(-04) pg TEQ m(-3) and 1.6E(+01) pg TEQ g(-1), respectively. Spatially, air and soil PCN concentrations were found to be high at Rahim Yar Khan (agricultural region)...
  60. Silva A, Nascimento A, Vitória M, Rabbani A, Soares A, Ledo A. Diversity and genetic stability in banana genotypes in a breeding program using inter simple sequence repeats (ISSR) markers. Genet Mol Res. 2017;16: pubmed publisher
    ..of this study was to analyze the genetic diversity of 21 banana genotypes (FHIA 23, PA42-44, Maçã, Pacovan Ken, Bucaneiro, YB42-47, Grand Naine, Tropical, FHIA 18, PA94-01, YB42-17, Enxerto, Japira, Pacovã, Prata-Anã, ..
  61. Chen Q, Li T, Gui M, Liu S, Zheng M, Ni J. Effects of ZnO nanoparticles on aerobic denitrification by strain Pseudomonas stutzeri PCN-1. Bioresour Technol. 2017;239:21-27 pubmed publisher
    ..In this study, inhibition of ZnO NPs to an aerobic denitrifier, Pseudomonas stutzeri PCN-1, was firstly reported. The results showed total nitrogen removal efficiency was decreased from 100% to 1...
  62. Javid M, Sasanakietkul T, Nicolson N, Gibson C, Callender G, Korah R, et al. DNA Mismatch Repair Deficiency Promotes Genomic Instability in a Subset of Papillary Thyroid Cancers. World J Surg. 2018;42:358-366 pubmed publisher
    ..MMR deficiency, potentially promoted by FOXO1 suppression, may explain the etiology for PTC development in some patients. FTC and FTA retain MMR activity and are likely caused by a different tumorigenic pathway. ..
  63. de Haan W, de Vries van der Weij J, Mol I, Hoekstra M, Romijn J, Jukema J, et al. PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice. Biochim Biophys Acta. 2009;1791:191-7 pubmed publisher
    ..were fed a diet with increasing amounts of the potent PXR agonist 5-pregnen-3beta-ol-20-one-16alpha-carbonitrile (PCN). In E3L and E3L.CETP mice, PCN increased liver lipids as well as plasma cholesterol and triglycerides...
  64. Pirani C, Buonavoglia A, Cirulli P, Baroni C, Chersoni S. The effect of the NRT files instrumentation on the quality of the surface of the root canal wall. J Appl Biomater Funct Mater. 2012;10:136-40 pubmed publisher
    To analyze in vitro, trough scanning electron microscope (SEM), the shaping ability of NRT NiTi rotary system (Mani, Inc, Toshigi-Ken, Japan).
  65. Fraser J, Maniskas M, Trout A, Lukins D, Parker L, Stafford W, et al. Intra-arterial verapamil post-thrombectomy is feasible, safe, and neuroprotective in stroke. J Cereb Blood Flow Metab. 2017;37:3531-3543 pubmed publisher
    ..We evaluated neuroprotective mechanism through in vitro primary cortical neuron (PCN) cultures...
  66. Lucca L, de Matos S, Kreutz T, Teixeira H, Veiga V, de Araújo B, et al. Anti-inflammatory Effect from a Hydrogel Containing Nanoemulsified Copaiba oil (Copaifera multijuga Hayne). AAPS PharmSciTech. 2018;19:522-530 pubmed publisher
    ..In skin permeation assay, both formulations, positively charged nanoemulsion (PCN) and negatively charged nanoemulsion (NCN), presented a high retention in epidermis (9.76 ± 2.65 ?g/g and 7...
  67. Dove A, Cook B, Irgebay Z, Vecsey C. Mechanisms of sleep plasticity due to sexual experience in Drosophila melanogaster. Physiol Behav. 2017;180:146-158 pubmed publisher
    ..Further, in ken/barbie male flies lacking external genitalia, courtship and physical contact without ejaculation were also unable ..
  68. Shellikeri S, Daulton R, Sertic M, Connolly B, Hogan M, Marshalleck F, et al. Pediatric Percutaneous Nephrostomy: A Multicenter Experience. J Vasc Interv Radiol. 2018;29:328-334 pubmed publisher
    To analyze technique, outcomes, and complications of a large series of pediatric percutaneous nephrostomy (PCN) procedures performed at 4 tertiary pediatric centers...
  69. Tynan S, Purohit A, Doxsey S, Vallee R. Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J Biol Chem. 2000;275:32763-8 pubmed
    ..Recently, we demonstrated the first known function for the LICs: binding to the centrosomal protein, pericentrin, which represents a novel, non-dynactin-based cargo-binding mechanism...
  70. Tsang W, Spektor A, Luciano D, Indjeian V, Chen Z, Salisbury J, et al. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. Mol Biol Cell. 2006;17:3423-34 pubmed
    ..Taken together, our data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. ..
  71. Numata S, Nakataki M, Iga J, Tanahashi T, Nakadoi Y, Ohi K, et al. Association study between the pericentrin (PCNT) gene and schizophrenia. Neuromolecular Med. 2010;12:243-7 pubmed publisher
    ..b>Pericentrin (PCNT) also interacts with DISC1 and recently single-nucleotide polymorphisms (SNPs) within the PCNT gene have ..
  72. Lee K, Rhee K. Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis. Cell Cycle. 2012;11:2476-85 pubmed publisher
    ..Separase is critical for centriole disengagement. Here, we showed that pericentrin B (PCNTB) is specifically cleaved by separase at the exit of mitosis...
  73. Unal S, Alanay Y, Cetin M, Boduroglu K, Utine E, Cormier Daire V, et al. Striking hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II (MOPD II): a potential role of pericentrin in hematopoiesis. Pediatr Blood Cancer. 2014;61:302-5 pubmed publisher
    ..Molecular testing showed that seven of the eight patients had pericentrin (PCNT) gene mutations. Hematological evaluation showed that 7 (87...
  74. Feng X, Linghu E, Chai N, Li H. New treatment of the pancreatic cystic neoplasm: Endoscopic ultrasonography-guided radiofrequency ablation combined with lauromacrogol ablation. Turk J Gastroenterol. 2017;: pubmed publisher
    ..In this case report, EUS-guided radiofrequency ablation combined with lauromacrogol ablation was applied for the first time in the treatment of PCN, and it showed complete resolution at a 3-month follow-up.
  75. Deng G, Wang Z. Triptycene-Based Microporous Cyanate Resins for Adsorption/Separations of Benzene/Cyclohexane and Carbon Dioxide Gas. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..contain different numbers of benzene rings per molecule were synthesized, from which two microporous cyanate resins PCN-TPC and PCN-TPPC were prepared...
  76. Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, et al. Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder. Biol Psychiatry. 2008;63:678-85 pubmed
    DISC1 has been suggested as a causative gene for psychoses in a large Scottish kindred. PCNT2 has recently been identified as an interacting partner of DISC1...
  77. Huang Doran I, Bicknell L, Finucane F, Rocha N, Porter K, Tung Y, et al. Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes. Diabetes. 2011;60:925-35 pubmed publisher
    Genetic defects in human pericentrin (PCNT), encoding the centrosomal protein pericentrin, cause a form of osteodysplastic primordial dwarfism that is sometimes reported to be associated with diabetes...
  78. Pagan J, Marzio A, Jones M, Saraf A, Jallepalli P, Florens L, et al. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nat Cell Biol. 2015;17:31-43 pubmed publisher
    ..We also found that Cep68 forms a complex with Cep215 (also known as Cdk5Rap2) and PCNT (also known as pericentrin), two PCM (pericentriolar material) proteins involved in centriole engagement...
  79. Li F, Wang X, Zhu M, Lou Z, Zhang Q, Zhu C, et al. Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms. Metab Brain Dis. 2015;30:1387-94 pubmed publisher
    ..In conclusion, we identified two novel mutations in the PCNT gene associated with MOPD II and intracranial aneurysms, and the mutations were expected to alter the stability and functioning of the protein by computer modeling. ..
  80. Kong L, Yin H, Yuan L. Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation. Biochem Biophys Res Commun. 2017;489:497-502 pubmed publisher
    ..We propose that Cep68 protein level needs to be fine-tuned in order to ensure that its direct interactors, such as the microcephaly protein Cep215 and PCNT, function properly. ..
  81. Mo J, Wang L, Huang X, Lu B, Zou C, Wei L, et al. Multifunctional nanoparticles for co-delivery of paclitaxel and carboplatin against ovarian cancer by inactivating the JMJD3-HER2 axis. Nanoscale. 2017;9:13142-13152 pubmed publisher
    ..In this study, we designed a novel folic acid-PEG-conjugated p-phosphonated calix[4]arene nanoparticle (Fp-PCN) for the simultaneous delivery of paclitaxel (PAC) and carboplatin (CAR) at an optimal ratio (5 : 1, mol : ..
  82. Kim J, Choi Y, Vallentin A, Hunrichs B, Hellerstein M, Peehl D, et al. Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res. 2008;68:6831-9 pubmed publisher
    ..We also find a unique effect of PKCbetaII inhibition on normalizing pericentrin (a protein regulating cytokinesis), especially in endothelial cells as well as in tumor cells...
  83. Kavazanjian E, Gutierrez A. Large scale centrifuge test of a geomembrane-lined landfill subject to waste settlement and seismic loading. Waste Manag. 2017;68:252-262 pubmed publisher
    ..The model was subjected to an input design motion intended to simulate strong ground motion from the 1994 Hyogo-ken Nanbu earthquake...
  84. Lloyd Jones K, Mahapatra M, Upadhyaya S, Paton D, Babu A, Hutchings G, et al. Genetic and antigenic characterization of serotype O FMD viruses from East Africa for the selection of suitable vaccine strain. Vaccine. 2017;35:6842-6849 pubmed publisher
    ..East and North Africa were characterized by virus neutralisation tests using bovine antisera to three existing (O/KEN/77/78, O/Manisa and O/PanAsia-2) and three putative (O/EA/2002, O/EA/2009 and O/EA/2010) vaccine strains and by ..
  85. Wyatt K. Interview with the Hon. Ken Wyatt: improving Indigenous health outcomes from a political viewpoint. Public Health Res Pract. 2017;27: pubmed publisher
    ..We spoke with the Honourable Ken Wyatt, the Minister for Indigenous Health and the Minister for Aged Care, about what has occurred over the past 50 ..
  86. Huang N, Yuan S, Drake H, Yang X, Pang J, Qin J, et al. Systematic Engineering of Single Substitution in Zirconium Metal-Organic Frameworks towards High-Performance Catalysis. J Am Chem Soc. 2017;: pubmed publisher
    ..In this work, we synthesized a series of isostructural PCN-224 analogues functionalized by ethyl, bromo, chloro, and fluoro groups on the porphyrin unit, which allowed us to ..
  87. Patel D, Mahimainathan L, Narasimhan M, Rathinam M, Henderson G. Ethanol (E) Impairs Fetal Brain GSH Homeostasis by Inhibiting Excitatory Amino-Acid Carrier 1 (EAAC1)-Mediated Cysteine Transport. Int J Mol Sci. 2017;18: pubmed publisher
    ..E reduced both PCN and cerebral cortical GSH and Cys up to 50% and the abridged GSH could be blocked by administration of N-..
  88. Golubkov V, Chekanov A, Doxsey S, Strongin A. Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis. J Biol Chem. 2005;280:42237-41 pubmed
    ..Our data suggested that the functionally important, integral, centrosomal protein, pericentrin-2, was a cleavage target of MT1-MMP in human and in canine cells and that the sequence of the cleavage sites ..
  89. Sillibourne J, Delaval B, Redick S, Sinha M, Doxsey S. Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. Mol Biol Cell. 2007;18:3667-80 pubmed
    b>Pericentrin is an integral centrosomal component that anchors regulatory and structural molecules to centrosomes. In a yeast two-hybrid screen with pericentrin we identified chromodomain helicase DNA-binding protein 4 (CHD4/Mi2beta)...
  90. Salemi M, Barone C, Romano C, Zolezzi F, Romano C, Scavuzzo C, et al. Gene expression profiling and qRT-PCR expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects. J Genet. 2012;91:e18-23 pubmed
  91. Die Q, Nie Z, Yue B, Zhu X, Gao X, Wang J, et al. Assessment of the temporal and spatial distribution of atmospheric PCNs and their air-soil exchange using passive air samplers in Shanghai, East China. Environ Sci Pollut Res Int. 2017;24:14365-14375 pubmed publisher
    ..6 to 153 pg/m3 (average of 40.0 pg/m3) in winter. In the soil samples, PCN concentrations were 54.7-1382 pg/g dry weight (average of 319 pg/g)...
  92. Jackson J, Kennedy C. Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish). Comp Biochem Physiol C Toxicol Pharmacol. 2017;200:34-41 pubmed publisher
    ..Zebrafish (Danio rerio) treated with the Pxr agonist pregnenolone 16?-carbonitrile (PCN) showed decreased P-gp (zebrafish Abcb4) and CYP3A (zebrafish Cyp3a65) mRNA levels after 48h exposure; however, ..