peptide YY


Gene Symbol: peptide YY
Description: peptide YY
Alias: PYY-I, PYY1, peptide YY, peptide tyrosine tyrosine, prepro-PYY
Species: human
Products:     peptide YY

Top Publications

  1. Wen J, Phillips S, Sarr M, Kost L, Holst J. PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon. Am J Physiol. 1995;269:G945-52 pubmed
    ..The ileum was also perfused with 154 mM NaCl while peptide YY (PYY) was infused by vein...
  2. Yang H. Central and peripheral regulation of gastric acid secretion by peptide YY. Peptides. 2002;23:349-58 pubmed
    b>Peptide YY (PYY) released postprandially from the ileum and colon displays a potent inhibition of cephalic and gastric phases of gastric acid secretion through both central and peripheral mechanisms...
  3. Weickert M, Reimann M, Otto B, Hall W, Vafeiadou K, Hallund J, et al. Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women. J Negat Results Biomed. 2006;5:11 pubmed
    ..indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, and thus influence body weight...
  4. Pfluger P, Kampe J, Castaneda T, Vahl T, D Alessio D, Kruthaupt T, et al. Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J Clin Endocrinol Metab. 2007;92:583-8 pubmed
    Recent findings suggest that low plasma peptide YY (PYY) levels may contribute to diet-induced human obesity and justify PYY replacement therapy...
  5. Jones T, Basilio J, Brophy P, McCammon M, Hickner R. Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin. Obesity (Silver Spring). 2009;17:1189-95 pubmed publisher
    ..HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, leptin, active ghrelin, total peptide YY (PYY), adiponectin, and resistin concentrations were measured...
  6. El Salhy M, Gundersen D, Hatlebakk J, Hausken T. High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. World J Gastroenterol. 2012;18:6070-5 pubmed publisher
    ..To investigate colonic endocrine cells in lymphocytic colitis (LC) patients...
  7. Habib A, Richards P, Rogers G, Reimann F, Gribble F. Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells. Diabetologia. 2013;56:1413-6 pubmed publisher
    Targeting the secretion of gut peptides such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) is a strategy under development for the treatment of diabetes and obesity, aiming to mimic the beneficial alterations in intestinal ..
  8. Adrian T, Ferri G, Bacarese Hamilton A, Fuessl H, Polak J, Bloom S. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology. 1985;89:1070-7 pubmed
    A radioimmunoassay has been developed for the new intestinal hormonal peptide tyrosine tyrosine [peptide YY (PYY)]...
  9. Hallden G, Hadi M, Hong H, Aponte G. Y receptor-mediated induction of CD63 transcripts, a tetraspanin determined to be necessary for differentiation of the intestinal epithelial cell line, hBRIE 380i cells. J Biol Chem. 1999;274:27914-24 pubmed
    b>Peptide YY (PYY) and neuropeptide Y (NPY) are peptides that coordinate intestinal activities in response to luminal and neuronal signals...

More Information

Publications122 found, 100 shown here

  1. Ekblad E, Sundler F. Distribution of pancreatic polypeptide and peptide YY. Peptides. 2002;23:251-61 pubmed
    ..A limited expression of PYY is found also in endocrine cells in the adrenal gland, respiratory tract and pituitary. Peripheral, particularly enteric, neurons also express PYY as does a restricted set of central neurons. ..
  2. Sandström O, El Salhy M. Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY. Peptides. 2002;23:263-7 pubmed
    Pancreatic polypeptide (PP) and peptide YY (PYY) are related neuroendocrine peptides that are expressed in specialized cells. PP is found around the time of birth in different species. PYY in mice and rats has been extensively studied...
  3. El Salhy M, Suhr O, Danielsson A. Peptide YY in gastrointestinal disorders. Peptides. 2002;23:397-402 pubmed
    ..Thus, in cases where an increase or decrease in PYY is desirable, a diet that increases or decreases PYY synthesis and release can be followed, or a receptor agonist or antagonist can be utilized. ..
  4. Imamura M. Effects of surgical manipulation of the intestine on peptide YY and its physiology. Peptides. 2002;23:403-7 pubmed
    ..After total colectomy, PYY release is reduced first due to reduction of PYY-containing cells, then gradually increases with time, contributing to adaptation of the digestive organs to the new condition. ..
  5. Kim B, Carlson O, Jang H, Elahi D, Berry C, Egan J. Peptide YY is secreted after oral glucose administration in a gender-specific manner. J Clin Endocrinol Metab. 2005;90:6665-71 pubmed
    Previous studies with small numbers of subjects showed a negative correlation between plasma peptide YY (PYY) levels and obesity. If correct, this would imply that low PYY levels might be involved in the pathogenesis of obesity...
  6. Nematy M, O Flynn J, Wandrag L, Brynes A, Brett S, Patterson M, et al. Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study. Crit Care. 2006;10:R10 pubmed
    ..Recent evidence suggests that gut released peptides, such as ghrelin and peptide YY (PYY) regulate the initiation and termination of meals and could play a role in the altered eating behaviour of ..
  7. Feltrin K, Patterson M, Ghatei M, Bloom S, Meyer J, Horowitz M, et al. Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Peptides. 2006;27:1638-43 pubmed
    We have evaluated the effects of fatty acid chain length on ghrelin, peptide YY (PYY), glucagon-like peptide-2 (GLP-2) and pancreatic polypeptide (PP) secretion and hypothesized that intraduodenal administration of dodecanoic ("C12&..
  8. Vazquez Roque M, Camilleri M, Stephens D, Jensen M, Burton D, Baxter K, et al. Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people. Gastroenterology. 2006;131:1717-24 pubmed
    b>Peptide YY (PYY) levels are reported to be decreased in obesity. The relation between gastric functions, satiation, and gut hormones in obesity is incompletely understood...
  9. Batterham R, ffytche D, Rosenthal J, Zelaya F, Barker G, Withers D, et al. PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature. 2007;450:106-9 pubmed
    ..An increased understanding of how such homeostatic and higher brain functions are integrated may pave the way for the development of new treatment strategies for obesity. ..
  10. Jacobsen S, Olesen S, Dirksen C, Jørgensen N, Bojsen Møller K, Kielgast U, et al. Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects. Obes Surg. 2012;22:1084-96 pubmed publisher
    ..peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2 (GLP-2), peptide YY(3-36) (PYY), cholecystokinin (CCK), total and active ghrelin, gastrin, somatostatin, pancreatic polypeptide (PP),..
  11. El Salhy M, Umezawa K. Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis. Int J Mol Med. 2016;37:556-64 pubmed publisher
    ..were sacrificed and tissue samples from the colon were immunostained for chromogranin A (CgA), serotonin, peptide YY (PYY), enteroglucagon, pancreatic polypeptide (PP), somatostatin, leukocytes, B/T lymphocytes, B lymphocytes, T ..
  12. Skrha J, Busek P, Uhrova J, Hrabal P, Kmochová K, Laclav M, et al. Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss. Pancreatology. 2017;17:89-94 pubmed publisher
    ..of glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide 1 (GLP-1), pancreatic polypeptide (PP), peptide YY (PYY) and neuropeptide Y (NPY), and cytokines leptin and adiponectin in 94 patients with histologically ..
  13. Schroeter J, Fenn C, Small B. Elucidating the roles of gut neuropeptides on channel catfish feed intake, glycemia, and hypothalamic NPY and POMC expression. Comp Biochem Physiol A Mol Integr Physiol. 2015;188:168-74 pubmed publisher
    ..peptide (GRP), cholecystokinin (CCK), glucagon-like peptide (GLP), pancreatic polypeptide (PP), and peptide YY (PYY) on appetite, glycemia, and hypothalamic expression of NPY and POMC in channel catfish...
  14. Breij L, Mulder M, van Vark van der Zee L, Hokken Koelega A. Appetite-regulating hormones in early life and relationships with type of feeding and body composition in healthy term infants. Eur J Nutr. 2017;56:1725-1732 pubmed publisher
    ..of ghrelin, leptin, insulin, glucose-dependent insulinotropic peptide (GIP), pancreatic polypeptide (PP) and peptide YY (PYY) at 3 months and in 41 infants also at 6 months and their associations with type of feeding and ..
  15. Stote K, Corkum A, Sweeney M, Shakerley N, Kean T, Gottschall Pass K. Postprandial Effects of Blueberry (Vaccinium angustifolium) Consumption on Glucose Metabolism, Gastrointestinal Hormone Response, and Perceived Appetite in Healthy Adults: A Randomized, Placebo-Controlled Crossover Trial. Nutrients. 2019;11: pubmed publisher
    ..gastrointestinal hormones, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), peptide YY (PYY) concentrations and perceived appetite did not change significantly with blueberry consumption...
  16. Zhang L, Yagi M, Herzog H. The role of NPY and ghrelin in anorexia nervosa. Curr Pharm Des. 2012;18:4766-78 pubmed of the most strongly stimulating agents for food intake while its two other closely related family members peptide YY (PYY) and pancreatic polypeptide (PP) released from the gut induce satiety...
  17. Heruc G, Little T, Kohn M, Madden S, Clarke S, Horowitz M, et al. Appetite Perceptions, Gastrointestinal Symptoms, Ghrelin, Peptide YY and State Anxiety Are Disturbed in Adolescent Females with Anorexia Nervosa and Only Partially Restored with Short-Term Refeeding. Nutrients. 2018;11: pubmed publisher, appetite perceptions, GI symptoms, state anxiety, and plasma acyl-ghrelin, cholecystokinin (CCK), peptide tyrosine tyrosine (PYY) and pancreatic polypeptide (PP) concentrations were assessed at baseline and in response to a ..
  18. Rigamonti A, Leoncini R, Casnici C, Marelli O, Col A, Tamini S, et al. Whey Proteins Reduce Appetite, Stimulate Anorexigenic Gastrointestinal Peptides and Improve Glucometabolic Homeostasis in Young Obese Women. Nutrients. 2019;11: pubmed publisher
    ..and anorexigenic gastrointestinal peptides (pancreatic polypeptide or PP, glucagon-like peptide 1 or GLP-1 and peptide YY or PYY) in a cohort of obese young women (n = 9; age: 18.1 ± 3.0 years; body mass index, BMI: 38.8 ± 4...
  19. Rock C, Flatt S, Barkai H, Pakiz B, Heath D. A walnut-containing meal had similar effects on early satiety, CCK, and PYY, but attenuated the postprandial GLP-1 and insulin response compared to a nut-free control meal. Appetite. 2017;117:51-57 pubmed publisher
    ..0433), and peptide YY, cholecystokinin and ghrelin did not differ after the two meals...
  20. Saydam B, Yildiz B. Gut-Brain Axis and Metabolism in Polycystic Ovary Syndrome. Curr Pharm Des. 2016;22:5572-5587 pubmed
    ..hormone whereas anorexigenic peptides include glucagon like peptide-1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY) and cholecystokinin (CCK)...
  21. Svane M, Bojsen Møller K, Martinussen C, Dirksen C, Madsen J, Reitelseder S, et al. Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. Gastroenterology. 2019;156:1627-1641.e1 pubmed publisher
    ..of plasma glucose and amino acids were accompanied by higher secretion of insulin, glucagon-like peptide 1, peptide YY, and cholecystokinin after RYGB, whereas levels of ghrelin were lower after SG, compared with RYGB and controls...
  22. El Salhy M, Mazzawi T, Umezawa K, Gilja O. Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis. Int J Mol Med. 2016;38:1743-1751 pubmed publisher
    ..These substances may also interfere with the colonogenic activity and the differentiation of the stem-cell secretory lineage into mature enteroendocrine cells. ..
  23. Kuhre R, Wewer Albrechtsen N, Larsen O, Jepsen S, Balk Møller E, Andersen D, et al. Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Mol Metab. 2018;11:84-95 pubmed publisher
    ..The mechanisms of GLP-1, neurotensin, and peptide YY (PYY) secretion was secondary to intestinal absorption and depended on activation of basolateral membrane Takeda ..
  24. Guemes M, Rahman S, Shah P, Hussain K. Enteroinsular hormones in two siblings with Donohue syndrome and complete leptin deficiency. Pediatr Diabetes. 2018;19:675-679 pubmed publisher gut hormones active glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), ghrelin, peptide YY (PYY) and leptin were analyzed using a Multiplex assay. Results were compared to those of 2 pediatric controls...
  25. Byrne C, Chambers E, Alhabeeb H, Chhina N, Morrison D, Preston T, et al. Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods. Am J Clin Nutr. 2016;104:5-14 pubmed publisher
    ..These observations were not related to changes in blood peptide YY (PYY), glucagon-like peptide 1 (GLP-1), glucose, or insulin concentrations...
  26. Olli K, Salli K, Alhoniemi E, Saarinen M, Ibarra A, Vasankari T, et al. Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants. Nutr J. 2015;14:2 pubmed publisher
    ..of satiety-related peptides, namely ghrelin, cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY), as well as SCFAs and lactic acid were assessed...
  27. He C, Zhang J, Gao S, Meng F, Bu G, Li J, et al. Molecular characterization of three NPY receptors (Y2, Y5 and Y7) in chickens: Gene structure, tissue expression, promoter identification, and functional analysis. Gen Comp Endocrinol. 2016;236:24-34 pubmed publisher
    Six neuropeptide Y (NPY) receptors are suggested to mediate the biological actions of NPY, peptide YY (PYY), and pancreatic polypeptide (PP), such as food intake in birds, however, information regarding the structure and signaling of ..
  28. Pankova A, Kralikova E, Kavalkova P, Stepankova L, Zvolská K, Haluzik M. No change in serum incretins levels but rise of leptin levels after smoking cessation: a pilot study. Physiol Res. 2016;65:651-659 pubmed
    ..In conclusions, smoking cessation increased leptin levels probably owing to weight gain while it did not influence incretin levels. ..
  29. El Salhy M, Umezawa K. Effects of AP‑1 and NF‑κB inhibitors on colonic endocrine cells in rats with TNBS‑induced colitis. Mol Med Rep. 2016;14:1515-22 pubmed publisher
    ..The expression density of these endocrine cell types was restored to control levels following treatment with AP‑1 or NF‑κB inhibitors. These results indicated that the immune system and enteroendocrine cells interact in IBD. ..
  30. El Salhy M, Gilja O. Abnormalities in ileal stem, neurogenin 3, and enteroendocrine cells in patients with irritable bowel syndrome. BMC Gastroenterol. 2017;17:90 pubmed publisher
    ..and immunostained for Musashi-1 (Msi-1), neurogenin 3 (NEUROG3), chromogranin A (CgA), serotonin, peptide YY (PYY), oxyntomodulin (enteroglucagon), pancreatic polypeptide, and somatostatin...
  31. Yang H, Kawakubo K, Wong H, Ohning G, Walsh J, Tache Y. Peripheral PYY inhibits intracisternal TRH-induced gastric acid secretion by acting in the brain. Am J Physiol Gastrointest Liver Physiol. 2000;279:G575-81 pubmed
    The site of action of peripheral peptide YY (PYY)-induced inhibition of vagally stimulated gastric acid secretion was studied using immunoneutralization with PYY antibody in urethan-anesthetized rats...
  32. Siahanidou T, Mandyla H, Militsi H, Papassotiriou I, Chrousos G. Peptide YY (3-36) represents a high percentage of total PYY immunoreactivity in preterm and full-term infants and correlates independently with markers of adiposity and serum ghrelin concentrations. Pediatr Res. 2007;62:200-3 pubmed
    The gut hormone peptide YY 3-36 [PYY (3-36)] has been suggested to posses anorexigenic actions in animals and human adults. However, its circulating concentrations and function have not been studied in neonates...
  33. Cegla J, Cuenco J, Minnion J, Ghourab S, Hostomska K, Tan T, et al. Pharmacokinetics and pharmacodynamics of subcutaneously administered PYY3-36 and its analogues in vivo. Lancet. 2015;385 Suppl 1:S28 pubmed publisher
  34. Forbes S, Stafford S, Coope G, Heffron H, Real K, Newman R, et al. Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models. Diabetes. 2015;64:3763-71 pubmed publisher
    ..acid receptor 2 (FFA2) is expressed on enteroendocrine L cells that release glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) when activated by short-chain fatty acids (SCFAs)...
  35. El Salhy M, Hausken T. The role of the neuropeptide Y (NPY) family in the pathophysiology of inflammatory bowel disease (IBD). Neuropeptides. 2016;55:137-44 pubmed publisher
    ..These neurohormones are believed to include members of the neuropeptide YY (NPY) family, which comprises NPY, peptide YY (PYY), and pancreatic polypeptide (PP)...
  36. van der Beek C, Canfora E, Lenaerts K, Troost F, Damink S, Holst J, et al. Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men. Clin Sci (Lond). 2016;130:2073-2082 pubmed publisher
    ..78±0.28 compared with -0.78±0.89 g fat 2 h-1, P=0.015), fasting peptide YY (PYY, P=0.01) and postprandial glucose and insulin concentrations (P<0...
  37. Rigamonti A, Agosti F, Compri E, Giunta M, Marazzi N, Muller E, et al. Anorexigenic postprandial responses of PYY and GLP1 to slow ice cream consumption: preservation in obese adolescents, but not in obese adults. Eur J Endocrinol. 2013;168:429-36 pubmed publisher
    ..Circulating levels of glucagon-like peptide 1 (GLP1), peptide YY (PYY), glucose, insulin, and triglycerides were measured over 210? min...
  38. Zhang X, Cheng Z, Xiao Z, Du X, Du J, Li Y, et al. Comparison of Short- and Mid-term Efficacy and the Mechanisms of Gastric Bypass Surgeries on Managing Obese and Nonobese Type 2 Diabetes Mellitus: A Prospective Study. Arch Med Res. 2015;46:303-9 pubmed publisher
    ..Meanwhile, β-cell function, glucagon-like peptide 1 (GLP-1), peptide YY (PYY) and gastric inhibitory polypeptide (GIP) levels were also investigated...
  39. Egerod K, Engelstoft M, Lund M, Grunddal K, Zhao M, Barir Jensen D, et al. Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells. Endocrinology. 2015;156:3909-23 pubmed publisher
    ..Thus, the article provides a comprehensive map of receptors through which SST secretion is regulated by hormones, neurotransmitters, neuropeptides and metabolites that act directly on the SST cells in the gastric mucosa. ..
  40. Espinós J, Turró R, Moragas G, Bronstone A, Buchwald J, Mearin F, et al. Gastrointestinal Physiological Changes and Their Relationship to Weight Loss Following the POSE Procedure. Obes Surg. 2016;26:1081-9 pubmed publisher
    ..Weight loss following POSE may be mediated through changes in gastrointestinal neuro-endocrine physiology. ..
  41. Wagner L, Kaestner F, Wolf R, Stiller H, Heiser U, Manhart S, et al. Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation. Neuropeptides. 2016;57:21-34 pubmed publisher
    ..Post-translational modification of DPP4-isoforms and degradation of NPY, Peptide YY (PYY), Galanin-like peptide (GALP), Orexin B (OrxB), OrxA, pituitary adenylate cyclase-activating polypeptide (..
  42. Toräng S, Bojsen Møller K, Svane M, Hartmann B, Rosenkilde M, Madsbad S, et al. In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans. Am J Physiol Regul Integr Comp Physiol. 2016;310:R866-74 pubmed publisher
    b>Peptide YY (PYY) is a 36-amino-acid peptide released from enteroendocrine cells upon food intake...
  43. Wu W, Zhou H, Pestka J. Potential roles for calcium-sensing receptor (CaSR) and transient receptor potential ankyrin-1 (TRPA1) in murine anorectic response to deoxynivalenol (vomitoxin). Arch Toxicol. 2017;91:495-507 pubmed publisher
    ..inhibited both DON-induced food refusal and plasma elevations of the satiety hormones cholecystokinin (CCK) and peptide YY3-36 (PYY3-36); cotreatment with both antagonists additively suppressed both anorectic and ..
  44. Magouliotis D, Tasiopoulou V, Sioka E, Chatedaki C, Zacharoulis D. Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis. Obes Surg. 2017;27:1345-1357 pubmed publisher
    ..acids (BCAAs) decreased, while trimethylamine-n-oxide (TMAO); glucagon-like peptide 1, 2 (GLP-1, GLP-2); and peptide YY (PYY) increased postoperatively. Postoperative gut microbiota was similar to that of lean and less obese objects...
  45. AL ABSI M, Lemieux A, Nakajima M. Peptide YY and ghrelin predict craving and risk for relapse in abstinent smokers. Psychoneuroendocrinology. 2014;49:253-9 pubmed publisher
    ..This study investigated the ability of peptide YY (PYY) and ghrelin during the initial 24-48 h of a smoking cessation attempt to predict smoking relapse at 4 ..
  46. Rhee N, Wahlgren C, Pedersen J, Mortensen B, Langholz E, Wandall E, et al. Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes. Diabetologia. 2015;58:2254-8 pubmed publisher
    ..taken during surgery and enteroscopy were immunohistochemically stained for glucagon-like peptide-1 (GLP-1), peptide YY (PYY), cholecystokinin (CCK), glucose-dependent insulinotropic polypeptide (GIP) and prohormone convertase 2 (..
  47. Alhadeff A, Golub D, Hayes M, Grill H. Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor. Am J Physiol Endocrinol Metab. 2015;309:E759-66 pubmed publisher
    ..Together, these results highlight the lPBN as a novel site of action for the intake-stimulatory effects of central PYY-Y1 receptor signaling. ..
  48. Steinert R, Gerspach A, Gutmann H, Asarian L, Drewe J, Beglinger C. The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Clin Nutr. 2011;30:524-32 pubmed publisher
    ..originally identified in the oral epithelium) to modulate the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)...
  49. Hill B, De Souza M, Williams N. Characterization of the diurnal rhythm of peptide YY and its association with energy balance parameters in normal-weight premenopausal women. Am J Physiol Endocrinol Metab. 2011;301:E409-15 pubmed publisher
    ..Thus, PYY varies in accordance with energy content and RMR, supporting a role for PYY in energy balance modulation. ..
  50. Köşüş A, Köşüş N, UsluoÄŸullari B, Hizli D, Namuslu M, Ayyıldız A. Gut satiety hormones and hyperemesis gravidarum. Arch Gynecol Obstet. 2015;292:1225-30 pubmed publisher
    ..blood samples were taken from all subjects for measurement of plasma gut hormone levels; obestatin (pg/mL), peptide YY (PYY), pancreatic polypeptide (PP) and cholecystokinin (CCK)...
  51. Casajoana A, Pujol J, García A, Elvira J, Virgili N, de Oca F, et al. Predictive Value of Gut Peptides in T2D Remission: Randomized Controlled Trial Comparing Metabolic Gastric Bypass, Sleeve Gastrectomy and Greater Curvature Plication. Obes Surg. 2017;27:2235-2245 pubmed publisher
    ..Enhanced GLP-1 secretion 1 month after surgery was a determinant of glucose metabolism improvement. Registration number ( ): NCT14104758. ..
  52. Stoeckel L, Weller R, Giddings M, Cox J. Peptide YY levels are associated with appetite suppression in response to long-chain fatty acids. Physiol Behav. 2008;93:289-95 pubmed
    Release of peptide YY(3-36) (PYY(3-36)) has been proposed to contribute to postprandial satiety...
  53. Toräng S, Veedfald S, Rosenkilde M, Hartmann B, Holst J. The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo. Physiol Rep. 2015;3: pubmed publisher
    b>Peptide YY (PYY) is a 36 amino acid peptide hormone released from enteroendocrine cells. An N-terminally degraded metabolite, PYY3-36, has anorexigenic effects, which makes the PYY system a target for obesity treatment...
  54. Nguyen N, Fraser R, Bryant L, Chapman M, Wishart J, Holloway R, et al. The relationship between gastric emptying, plasma cholecystokinin, and peptide YY in critically ill patients. Crit Care. 2007;11:R132 pubmed
    Cholecystokinin (CCK) and peptide YY (PYY) are released in response to intestinal nutrients and play an important physiological role in regulation of gastric emptying (GE)...
  55. Aoki K, Kondo M, Okuda M, Saneyasu T, Honda K, Kamisoyama H. Identification, expression analysis, and functional characterization of peptide YY in chickens (Gallus gallus domesticus). Gen Comp Endocrinol. 2017;242:11-17 pubmed publisher
    b>Peptide YY (PYY) functions as a postprandial satiety signal in mammals. However, the genomic information and physiological roles of chicken PYY have not yet been clarified, although PYY peptide was isolated from chicken intestines in 1992...
  56. Johnson M, Saffrey M, Taylor V. Glucagon-like peptide-1 (GLP-1) increases in plasma and colon tissue prior to estrus and circulating levels change with increasing age in reproductively competent Wistar rats. Peptides. 2017;90:55-62 pubmed publisher
    ..Slightly older females had reduced fed plasma GLP-1 suggesting that a relaxation of regulatory control of this incretin hormone may also take place with increasing age in reproductively competent females. ..
  57. Lloyd B, Ravi P, Mendes N, Klibanski A, Misra M. Peptide YY levels across pubertal stages and associations with growth hormone. J Clin Endocrinol Metab. 2010;95:2957-62 pubmed publisher
    ..b>Peptide YY (PYY) is an anorexigenic hormone that is high in anorexia nervosa and low in obesity, inhibits GnRH secretion, ..
  58. Bligh H, Godsland I, Frost G, Hunter K, Murray P, MacAulay K, et al. Plant-rich mixed meals based on Palaeolithic diet principles have a dramatic impact on incretin, peptide YY and satiety response, but show little effect on glucose and insulin homeostasis: an acute-effects randomised study. Br J Nutr. 2015;113:574-84 pubmed publisher
    ..Plasma glucose, insulin, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and peptide YY (PYY) concentrations were measured over a period of 180 min...
  59. Svendsen B, Holst J. Regulation of gut hormone secretion. Studies using isolated perfused intestines. Peptides. 2016;77:47-53 pubmed publisher
  60. Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, et al. Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell. 2013;23:477-88 pubmed publisher
    ..Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment. ..
  61. Bala V, Rajagopal S, Kumar D, Nalli A, Mahavadi S, Sanyal A, et al. Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S. Front Physiol. 2014;5:420 pubmed publisher
  62. Ramracheya R, McCulloch L, Clark A, Wiggins D, Johannessen H, Olsen M, et al. PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery. Cell Rep. 2016;15:944-950 pubmed publisher
    ..These latter effects were reversed following neutralization of the gut hormone peptide tyrosine tyrosine (PYY) but persisted in the presence of a glucagon-like peptide-1 (GLP-1) receptor antagonist...
  63. Utz A, Lawson E, Misra M, Mickley D, Gleysteen S, Herzog D, et al. Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa. Bone. 2008;43:135-139 pubmed publisher
    ..b>Peptide YY (PYY) is an anorexigenic peptide derived primarily from the intestine, with actions mediated via activation of Y ..
  64. Priori D, Colombo M, Clavenzani P, Jansman A, Lallès J, Trevisi P, et al. The Olfactory Receptor OR51E1 Is Present along the Gastrointestinal Tract of Pigs, Co-Localizes with Enteroendocrine Cells and Is Modulated by Intestinal Microbiota. PLoS ONE. 2015;10:e0129501 pubmed publisher
    ..OR51E1 co-localization with serotonin (5HT) and peptide YY (PYY) were evaluated in PL and CO respectively...
  65. Schmidt J, Sjödin A, Stevner L, Ritz C, Michaelsen N, Thomsen A, et al. Serum lipase activity and concentration during intravenous infusions of GLP-1 and PYY3-36 and after ad libitum meal ingestion in overweight men. Physiol Rep. 2016;4: pubmed
    ..serum lipase activity and protein concentration of intravenous infusions of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY3-36) and of an ad libitum meal in healthy overweight men...
  66. Coutinho S, Halset E, GÃ¥sbakk S, Rehfeld J, Kulseng B, Truby H, et al. Compensatory mechanisms activated with intermittent energy restriction: A randomized control trial. Clin Nutr. 2018;37:815-823 pubmed publisher consumption (PFC)), and appetite-regulating hormones (active ghrelin (AG), cholecystokinin (CCK), total peptide YY (PYY), active glucagon-like peptide-1 (GLP-1), and insulin) were measured before and after WL...
  67. Olsen J, Kofoed J, Østergaard S, Wulff B, Nielsen F, Jorgensen R. Metabolism of peptide YY 3-36 in Göttingen mini-pig and rhesus monkey. Peptides. 2016;78:59-67 pubmed publisher
    b>Peptide YY 3-36-amide (PYY3-36) is a peptide hormone, which is known to decrease appetite and food-intake by activation of the Y2 receptor...
  68. Yamaguchi E, Yasoshima Y, Shimura T. Systemic administration of anorexic gut peptide hormones impairs hedonic-driven sucrose consumption in mice. Physiol Behav. 2017;171:158-164 pubmed publisher
    A number of reports suggest that gut hormones such as cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and peptide YY(3-36) (PYY3-36), which are released postprandially, suppress homeostatic food intake and result in ..
  69. Lemieux A, AL ABSI M. Changes in circulating peptide YY and ghrelin are associated with early smoking relapse. Biol Psychol. 2018;131:43-48 pubmed publisher
    Ghrelin and peptide YY (PYY) during ad libitum smoking have been associated with decreased reported craving (ghrelin) and increased positive affect (PYY), and higher baseline ghrelin levels predicted subsequent increased risk of smoking ..
  70. Atanes P, Ruz Maldonado I, Hawkes R, Liu B, Zhao M, Huang G, et al. Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets. Cell Mol Life Sci. 2018;75:3039-3050 pubmed publisher
    ..out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets...
  71. Bard J, Walker M, Branchek T, Weinshank R. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J Biol Chem. 1995;270:26762-5 pubmed
    The pancreatic polypeptide family includes pancreatic polypeptide (PP), neuropeptide Y (NPY), and peptide YY (PYY)...
  72. Heden T, Liu Y, Sims L, Kearney M, Whaley Connell A, Chockalingam A, et al. Liquid meal composition, postprandial satiety hormones, and perceived appetite and satiety in obese women during acute caloric restriction. Eur J Endocrinol. 2013;168:593-600 pubmed publisher was to compare postprandial satiety regulating hormone responses (pancreatic polypeptide (PP) and peptide tyrosine tyrosine (PYY)) and visual analog scale- (VAS) assessed perceived appetite and satiety between liquid high-..
  73. Scheid J, Birch L, Williams N, Rolls B, De Souza M. Postprandial peptide YY is lower in young college-aged women with high dietary cognitive restraint. Physiol Behav. 2013;120:26-33 pubmed publisher
    Acylated ghrelin and peptide YY (PYY3-36) are involved in appetite-regulation and energy homeostasis...
  74. Facer P, Bishop A, Cole G, Aitchison M, Kendall C, van Aswegen G, et al. Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells. Gastroenterology. 1989;97:48-57 pubmed
    ..somatostatin 28 (1-14), somatostatin cryptic peptide, glucagon, glucagonlike peptides 1 and 2, glicentin, peptide YY, glucose-dependent insulinotropic peptide, secretin, neurotensin, and substance P in human fetal stomach and ..
  75. Kanatani A, Mashiko S, Murai N, Sugimoto N, Ito J, Fukuroda T, et al. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. 2000;141:1011-6 pubmed
    ..At least six subtypes of NPY, peptide YY (PYY), and pancreatic polypeptide (PP) receptors have been identified in mice...
  76. Bertenshaw G, Turk B, Hubbard S, Matters G, Bylander J, Crisman J, et al. Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. J Biol Chem. 2001;276:13248-55 pubmed
    ..Homology models of the mouse meprin alpha and beta protease domains, based on the astacin crystal structure, revealed active site differences that can account for the marked differences in substrate specificity of the two subunits. ..
  77. Chan J, Stoyneva V, Kelesidis T, Raciti P, Mantzoros C. Peptide YY levels are decreased by fasting and elevated following caloric intake but are not regulated by leptin. Diabetologia. 2006;49:169-73 pubmed
    b>Peptide YY (PYY) is a gut-derived hormone that has been shown to reduce short-term food intake in animals and humans. It has been proposed that deficiency of PYY contributes to obesity in humans...
  78. Beglinger C, Degen L. Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?. Physiol Behav. 2006;89:460-4 pubmed
    ..The review focuses on the question, whether the two peptides are true endocrine factors that act as physiologic, hormonal regulators of appetite. ..
  79. Bacha F, Arslanian S. Ghrelin and peptide YY in youth: are there race-related differences?. J Clin Endocrinol Metab. 2006;91:3117-22 pubmed
    ..Ghrelin is a "hunger" peptide that is high preprandially and decreases postprandially, and peptide YY (PYY) is a "satiety" hormone increasing after meals...
  80. Lomenick J, Clasey J, Anderson J. Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children. Obesity (Silver Spring). 2008;16:547-52 pubmed publisher
    Ghrelin and peptide YY (PYY) are two gut hormones that have effects on appetite...
  81. Lawson E, Eddy K, Donoho D, Misra M, Miller K, Meenaghan E, et al. Appetite-regulating hormones cortisol and peptide YY are associated with disordered eating psychopathology, independent of body mass index. Eur J Endocrinol. 2011;164:253-61 pubmed publisher
    Disordered eating occurs in women at both weight extremes of anorexia nervosa (AN) and obesity. Cortisol, peptide YY (PYY), leptin, and ghrelin are hormones involved in appetite and feeding behavior that vary with weight and body fat...
  82. Cahill F, Ji Y, Wadden D, Amini P, Randell E, Vasdev S, et al. The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study. PLoS ONE. 2014;9:e95235 pubmed publisher
    ..Although the effect size of the positive association of PYY with obesity in women is small, and potentially negligible, it may in fact represent a protective response against significant weight gain. ..
  83. Steingoetter A, Buetikofer S, Curcic J, Menne D, Rehfeld J, Fried M, et al. The Dynamics of Gastric Emptying and Self-Reported Feelings of Satiation Are Better Predictors Than Gastrointestinal Hormones of the Effects of Lipid Emulsion Structure on Fat Digestion in Healthy Adults-A Bayesian Inference Approach. J Nutr. 2017;147:706-714 pubmed publisher
    ..sought to deduce the relative importance of the hormones ghrelin, cholecystokinin, glucagon-like peptide-1, and peptide YY (PYY) in controlling fat emptying and related satiation...
  84. Gillespie A, Pan X, Marco Ramell A, Meharg C, Green B. Detailed characterisation of STC-1 cells and the pGIP/Neo sub-clone suggests the incretin hormones are translationally regulated. Peptides. 2017;96:20-30 pubmed publisher
    ..High Content Analysis found altered intracellular GLP-1, GIP, cholecystokinin (CCK) and peptide YY (PYY) levels and differing hormone co-localisation...
  85. Zhang X, Tang N, Qi J, Wang S, Hao J, Wu Y, et al. CCK reduces the food intake mainly through CCK1R in Siberian sturgeon (Acipenser baerii Brandt). Sci Rep. 2017;7:12413 pubmed publisher
    ..On the other hand, LY 225910, the CCK2R selective antagonist, partially reversed these effects. These results indicate CCK is a satiety factor inhibits the feeding of Siberian sturgeon primarily through CCK1R. ..
  86. Mannon P. Peptide YY as a growth factor for intestinal epithelium. Peptides. 2002;23:383-8 pubmed
    b>Peptide YY is an abundant distal gut hormone that may play a significant role in intestinal epithelial proliferation...
  87. Degen L, Drewe J, Piccoli F, Gräni K, Oesch S, Bunea R, et al. Effect of CCK-1 receptor blockade on ghrelin and PYY secretion in men. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1391-9 pubmed
    Cholecystokinin (CCK), peptide YY (PYY), and ghrelin have been proposed to act as satiety hormones...
  88. Nguyen N, Fraser R, Chapman M, Bryant L, Wishart J, Holloway R, et al. Fasting and nutrient-stimulated plasma peptide-YY levels are elevated in critical illness and associated with feed intolerance: an observational, controlled study. Crit Care. 2006;10:R175 pubmed
    ..In these patients, gastric motor responses to nutrients are disturbed. Peptide YY (PYY) slows gastric emptying...
  89. Siddiq A, Gueorguiev M, Samson C, Hercberg S, Heude B, Levy Marchal C, et al. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. Diabetologia. 2007;50:574-84 pubmed
    Genetic variants of genes for peptide YY (PYY), neuropeptide Y2 receptor (NPY2R) and pancreatic polypeptide (PPY) were investigated for association with severe obesity...
  90. Maier C, Riedl M, Vila G, Nowotny P, Wolzt M, Clodi M, et al. Cholinergic regulation of ghrelin and peptide YY release may be impaired in obesity. Diabetes. 2008;57:2332-40 pubmed publisher
    Ghrelin and peptide YY (PYY) are both hormones derived from the gastrointestinal tract involved in appetite regulation. The cholinergic part of the vagal nerve is involved in the regulation of glucose and insulin...
  91. Broom D, Batterham R, King J, Stensel D. Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. Am J Physiol Regul Integr Comp Physiol. 2009;296:R29-35 pubmed publisher
    ..of resistance and aerobic exercise on hunger and circulating levels of the gut hormones acylated ghrelin and peptide YY (PYY). Eleven healthy male students: age 21.1 +/- 0.3 yr, body mass index 23.1 +/- 0...
  92. Holler J, Schmitz J, Roehrig R, Wilker S, Hecker A, Padberg W, et al. Expression of peptide YY by human blood leukocytes. Peptides. 2014;58:78-82 pubmed publisher
    b>Peptide YY is produced by L cells in the mucosa of the distal ileum, colon, and rectum and may have systemic and paracrine functions. We hypothesized that peptide YY is expressed by peripheral blood mononuclear cells...