PEG3

Summary

Gene Symbol: PEG3
Description: paternally expressed 3
Alias: PW1, ZKSCAN22, ZNF904, ZSCAN24, paternally-expressed gene 3 protein, Kruppel-type zinc finger protein, zinc finger and SCAN domain-containing protein 24
Species: human
Products:     PEG3

Top Publications

  1. Kim J, Ashworth L, Branscomb E, Stubbs L. The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. Genome Res. 1997;7:532-40 pubmed
    b>Peg3 (paternally expressed gene 3) is the first imprinted gene detected in the proximal region of mouse chromosome 7...
  2. Relaix F, Wei X, Li W, Pan J, Lin Y, Bowtell D, et al. Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. Proc Natl Acad Sci U S A. 2000;97:2105-10 pubmed
    ..We have identified Pw1/Peg3 as a gene product induced during p53/c-myc-mediated apoptosis...
  3. Kim J, Bergmann A, Stubbs L. Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). Genomics. 2000;64:114-8 pubmed
    We have identified a novel human gene, ZIM2 (zinc-finger gene 2 from imprinted domain), located 25 kb downstream of PEG3 (paternally expressed gene 3). ZIM2 produces two different-size transcripts, 2.5 and 9...
  4. Kohda T, Asai A, Kuroiwa Y, Kobayashi S, Aisaka K, Nagashima G, et al. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. Genes Cells. 2001;6:237-47 pubmed
    Mouse imprinted gene Peg3 encodes a large C2H2 type zinc finger protein with unique characteristics. Peg3 knockout mice were found to show an impairment in maternal behaviour of the adult female...
  5. Johnson M, Wu X, Aithmitti N, Morrison R. Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. J Biol Chem. 2002;277:23000-7 pubmed
    ..We report here that Peg3/Pw1 is up-regulated after DNA damage in cortical neurons in a p53-dependent manner...
  6. Dowdy S, Gostout B, Shridhar V, Wu X, Smith D, Podratz K, et al. Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. Gynecol Oncol. 2005;99:126-34 pubmed
    To measure mRNA expression levels of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines and to determine if DNA methylation is involved in the control of PEG3 expression...
  7. Feng W, Marquez R, Lu Z, Liu J, Lu K, Issa J, et al. Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. Cancer. 2008;112:1489-502 pubmed publisher
    ..Two imprinted genes, paternally expressed 3 (PEG3) and aplasia Ras homologue member I (ARHI), are the most frequently down-regulated in ovarian cancers on gene ..
  8. Jiang X, Yu Y, Yang H, Agar N, Frado L, Johnson M. The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. J Biol Chem. 2010;285:8472-80 pubmed publisher
    The imprinted gene PEG3 confers parenting and sexual behaviors, alters growth and development, and regulates apoptosis. However, a molecular mechanism that can account for the diverse functions of Peg3/Pw1 is not known...
  9. Relaix F, Wei X, Wu X, Sassoon D. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. Nat Genet. 1998;18:287-91 pubmed
    ..We have determined that Pw1 is identical to Peg3, a paternally expressed gene of unknown function (and will therefore be referred to as Peg3 throughout this text)...

More Information

Publications125 found, 100 shown here

  1. Adnani L, Langevin L, Gautier E, Dixit R, Parsons K, Li S, et al. Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1. J Neurosci. 2015;35:13430-47 pubmed publisher
    ..g., Dlk1, Peg3, Ube3a, necdin, and Grb10)...
  2. Ebert S, Monteys A, Fox D, Bongers K, Shields B, Malmberg S, et al. The transcription factor ATF4 promotes skeletal myofiber atrophy during fasting. Mol Endocrinol. 2010;24:790-9 pubmed publisher
    ..These five mRNAs encode proteins previously implicated in growth suppression (p21(Cip1/Waf1), GADD45alpha, and PW1/Peg3) or titin-based stress signaling [muscle LIM protein (MLP) and cardiac ankyrin repeat protein (CARP)]...
  3. Liu L, Mao S, Ray C, Zhang Y, Bell F, Ng S, et al. Differential regulation of genomic imprinting by TET proteins in embryonic stem cells. Stem Cell Res. 2015;15:435-43 pubmed publisher
    ..By contrast, we did not observe a significant increase of DNA methylation imprint at the Peg3, Snrpn and Dlk1-Dio3 imprinted regions in ES cells lacking TET proteins...
  4. Buraschi S, Neill T, Iozzo R. Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy. Matrix Biol. 2019;75-76:260-270 pubmed publisher
    ..downstream of receptor engagement converge upon a newly-discovered nexus of autophagic machinery consisting of Peg3 for endothelial cell autophagy and mitostatin for tumor cell mitophagy...
  5. Jang H, Hong Y, Choi H, Song H, Byun S, Uhm S, et al. Changes in Parthenogenetic Imprinting Patterns during Reprogramming by Cell Fusion. PLoS ONE. 2016;11:e0156491 pubmed publisher
    ..In addition, methylation of several imprinted genes except Peg3 was comparable between hybrid cells and ESCs...
  6. Tonlorenzi R, Rossi G, Messina G. Isolation and Characterization of Vessel-Associated Stem/Progenitor Cells from Skeletal Muscle. Methods Mol Biol. 2017;1556:149-177 pubmed publisher
    ..This chapter provides detailed methods for isolation, culture, and characterization of MABs in light of the recent identification of a new marker, PW1 /Peg3, to screen and identify competent MABs before their use in cell therapy.
  7. Läppchen T, Dings R, Rossin R, Simon J, Visser T, Bakker M, et al. Novel analogs of antitumor agent calixarene 0118: Synthesis, cytotoxicity, click labeling with 2-[(18)F]fluoroethylazide, and in vivo evaluation. Eur J Med Chem. 2015;89:279-95 pubmed publisher
    ..respective precursors, a small series of 0118 analogs modified with short-chain linear alkyl substituents, and a PEG3-spaced calixarene dimer...
  8. Nye M, Hoyo C, Murphy S. In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. Toxicol In Vitro. 2015;29:544-50 pubmed publisher
    ..9% (MEG3) and 1.8% (MEG3-IG) at 5 μg/dL Pb, but were not statistically significant. The H19, NNAT, PEG3, PLAGL1, and SGCE/PEG10 DMRs showed a less than 0...
  9. Giuliano M, Herrera S, Christiny P, Shaw C, Creighton C, Mitchell T, et al. Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis. Breast Cancer Res. 2015;17:3 pubmed publisher
    ..with the presence of CTC clusters and with lung metastatic potential identified four genes (HLA-DP1A, GJA1, PEG3, and XIST)...
  10. Hu D, McKinnon R, Hulin J, Mackenzie P, Meech R. Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells. Int J Mol Sci. 2016;18: pubmed publisher
    ..in LNCaP cells, including genes known to modulate growth and proliferation of prostate cancer (PCGEM1, PEG3, EPHA3, and EFNB2) or other types of human cancers (TOX3, ST8SIA4, and SLITRK3
  11. Creeth H, McNamara G, Isles A, John R. Imprinted genes influencing the quality of maternal care. Front Neuroendocrinol. 2018;: pubmed publisher
    ..comes from observing alterations in the mother's behaviour when expression of the imprinted genes Phlda2 and Peg3 has been manipulated solely in the offspring...
  12. Lyssenko V, Groop L, Prasad R. Genetics of Type 2 Diabetes: It Matters From Which Parent We Inherit the Risk. Rev Diabet Stud. 2015;12:233-42 pubmed publisher
    ..Such PoO transmission is seen for variants in the KLF14, KCNQ1, GRB10, TCF7L2, THADA, and PEG3 genes...
  13. McDonald C, Liu L, Xiao L, Schaniel C, Li X. Genomic imprinting defect in Zfp57 mutant iPS cell lines. Stem Cell Res. 2016;16:259-63 pubmed
    ..Intriguingly, DNA methylation imprint was lost at the Peg1 and Peg3 but retained at the Snrpn and Dlk1-Dio3 imprinted regions in the iPS clones without zygotic Zfp57...
  14. Schmidt M, Schüler S, Hüttner S, von Eyss B, von Maltzahn J. Adult stem cells at work: regenerating skeletal muscle. Cell Mol Life Sci. 2019;: pubmed publisher
    ..on signaling pathways, cytoskeletal rearrangements, the importance of miRNAs, and the contribution of non-satellite cells such as immune cells, fibro-adipogenic progenitor cells, and PW1-positive/Pax7-negative interstitial cells.
  15. Perera B, Kim J. Next-generation sequencing-based 5' rapid amplification of cDNA ends for alternative promoters. Anal Biochem. 2016;494:82-4 pubmed publisher
    ..This protocol has successfully identified several alternative promoters for an imprinted gene, PEG3. Overall, this NGS-based 5'RACE protocol is a sensitive and reliable method for detecting low-abundant transcripts ..
  16. Ponzi M, Sidén Kiamos I, Bertuccini L, Currà C, Kroeze H, Camarda G, et al. Egress of Plasmodium berghei gametes from their host erythrocyte is mediated by the MDV-1/PEG3 protein. Cell Microbiol. 2009;11:1272-88 pubmed publisher
    ..Protein MDV-1/PEG3, like its Plasmodium falciparum orthologue, is present in gametocytes of both sexes, but more abundant in the ..
  17. Yin H, Wang H, Jiang W, Zhou Y, Ai S. Electrochemical immunosensor for N6-methyladenosine detection in human cell lines based on biotin-streptavidin system and silver-SiO2 signal amplification. Biosens Bioelectron. 2017;90:494-500 pubmed publisher
    ..strategy, anti-m6A antibody was selected as m6A recognition and capture reagent, silver nanoparticles and amine-PEG3-biotin functionalized SiO2 nanospheres (Ag@SiO2) was prepared and used as signal ..
  18. Ferraz de Souza B, Hudson Davies R, Lin L, Parnaik R, Hubank M, Dattani M, et al. Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal. J Clin Endocrinol Metab. 2011;96:E663-8 pubmed publisher
    ..This approach identified well-established SF-1 target genes (STAR, CYP11A) and several novel genes (VSNL1, ZIM2, PEG3, SOAT1, and MTSS1)...
  19. Ma P, De Waal E, Weaver J, Bartolomei M, Schultz R. A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes. Cell Rep. 2015;13:1552-60 pubmed publisher
    ..double-mutant growing oocytes exhibit global DNA hypomethylation and fail to establish imprinting marks for Igf2r, Peg3, and Srnpn...
  20. Yamanaka K, Yamashita K, Khatun H, Wada Y, Tatemoto H, Sakatani M, et al. Normal DNA methylation status in sperm from a somatic cell cloned bull and their fertilized embryos. Anim Sci J. 2018;89:1406-1414 pubmed publisher
    ..Here, we investigated the DNA methylation status of four developmentally regulated genes (PEG3, XIST, OCT4, and NANOG) in sperms from a cloned and a non-cloned bull, and blastocysts obtained by in vitro ..
  21. Rezvani G, Lui J, Barnes K, Baron J. A set of imprinted genes required for normal body growth also promotes growth of rhabdomyosarcoma cells. Pediatr Res. 2012;71:32-8 pubmed publisher
    ..decline is due, in part, to decline in the expression of growth-promoting imprinted genes including Mest, Plagl1, Peg3, Dlk1, and Igf2...
  22. Wang Q, Tang S, Song X, Deng T, Zhang T, Yin S, et al. High-glucose concentrations change DNA methylation levels in human IVM oocytes. Hum Reprod. 2018;33:474-481 pubmed publisher
    ..concentrations on DNA methylation of human oocytes? High-glucose concentrations altered DNA methylation levels of Peg3 and Adiponectin in human in vitro maturation oocytes...
  23. Varasteh Z, Rosenström U, Velikyan I, Mitran B, Altai M, Honarvar H, et al. The effect of mini-PEG-based spacer length on binding and pharmacokinetic properties of a 68Ga-labeled NOTA-conjugated antagonistic analog of bombesin. Molecules. 2014;19:10455-72 pubmed publisher
    ..3 nM, respectively. In normal mice all conjugates demonstrated similar biodistribution pattern, however 68Ga-NOTA-PEG3-RM26 showed lower liver uptake...
  24. Debbarma P, Raghuwanshi S, Singh J, Suyal D, Zaidi M, Goel R. Comparative in situ biodegradation studies of polyhydroxybutyrate film composites. 3 Biotech. 2017;7:178 pubmed publisher
    ..In the present study, a total of four bacterial strains, viz., MK3, PN12, PW1, and Lna3, were formulated into a consortium and subsequently used as biological tool for degradation of ..
  25. Moresi V, Garcia Alvarez G, Pristerá A, Rizzuto E, Albertini M, Rocchi M, et al. Modulation of caspase activity regulates skeletal muscle regeneration and function in response to vasopressin and tumor necrosis factor. PLoS ONE. 2009;4:e5570 pubmed publisher
    ..The contrasting effects of AVP and TNF in vivo are recapitulated in myogenic cell cultures, which express both PW1, a caspase activator, and Hsp70, a caspase inhibitor...
  26. Olivieri A, Bertuccini L, Deligianni E, Franke Fayard B, Currà C, Siden Kiamos I, et al. Distinct properties of the egress-related osmiophilic bodies in male and female gametocytes of the rodent malaria parasite Plasmodium berghei. Cell Microbiol. 2015;17:355-68 pubmed publisher
    ..We found that a drop in temperature triggers MOB clustering, independently of exposure to other stimuli. MDV1/PEG3, a protein associated with OB in Plasmodium berghei females, localizes to both non-clustered and clustered MOB, ..
  27. He H, Ye A, Kim J. Transcriptional Truncation of the Long Coding Imprinted Gene Usp29. PLoS ONE. 2016;11:e0158004 pubmed publisher
    Usp29 (Ubiquitin-specific protease 29) is a paternally expressed gene located upstream of another imprinted gene Peg3. In the current study, the transcription of this long coding gene spanning a 250-kb genomic distance was truncated using ..
  28. Özata D, Li X, Lee L, Liu J, Warsito D, Hajeri P, et al. Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors. Cell Death Dis. 2017;8:e2759 pubmed publisher
    ..we demonstrated that miR-514a-3p induced apoptosis through direct regulation of the paternally expressed gene 3 (PEG3), and ectopically expressed PEG3 could rescue the apoptotic effect of miR-514a-3p overexpression...
  29. Fadista J, Vikman P, Laakso E, Mollet I, Esguerra J, Taneera J, et al. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A. 2014;111:13924-9 pubmed publisher
    ..Notably, allelic imbalance in paternally expressed gene 3 (PEG3) was associated with its promoter methylation and T2D status...
  30. He H, Kim J. Regulation and function of the peg3 imprinted domain. Genomics Inform. 2014;12:105-13 pubmed publisher
    A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb genomic interval of the human and mouse ..
  31. Marjonen H, Toivonen M, Lahti L, Kaminen Ahola N. Early prenatal alcohol exposure alters imprinted gene expression in placenta and embryo in a mouse model. PLoS ONE. 2018;13:e0197461 pubmed publisher
    ..growth factor 2 (Igf2), H19, Small Nuclear Ribonucleoprotein Polypeptide N (Snrpn) and Paternally expressed gene 3 (Peg3), which all are known to be involved in embryonic and placental growth and development...
  32. Čamernik K, Marc J, Zupan J. Human Skeletal Muscle-Derived Mesenchymal Stem/Stromal Cell Isolation and Growth Kinetics Analysis. Methods Mol Biol. 2018;: pubmed publisher
    ..subpopulations of MSCs, such as paired box 7 (Pax-7)-positive satellite cells, fibro-/adipogenic progenitors, PW1-positive interstitial cells and others...
  33. Kärst S, Arends D, Heise S, Trost J, Yaspo M, Amstislavskiy V, et al. The direction of cross affects [corrected] obesity after puberty in male but not female offspring. BMC Genomics. 2015;16:904 pubmed publisher
    ..Obese males showed lower expression of the genetically imprinted and paternally expressed 3 (Peg3) gene (0.31 fold, p = 0.046) and higher expression of the androgen receptor (Ar) gene (2...
  34. Kumar D, Kumar S, Ayachit G, Bhairappanavar S, Ansari A, Sharma P, et al. Cross-Kingdom Regulation of Putative miRNAs Derived from Happy Tree in Cancer Pathway: A Systems Biology Approach. Int J Mol Sci. 2017;18: pubmed publisher
    ..The regulatory network analysis showed the association of some important hub proteins like GSK3B, NUMB, PEG3, ITGA2 and DLG2 with cancer-associated pathways...
  35. Sherwood C, Daines M, Price T, Vagner J, Boitano S. A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance. Am J Physiol Cell Physiol. 2014;307:C718-26 pubmed publisher
    ..In the present study, we used the newly developed PAR2 ligand 2at-LIGRLO(PEG3-Pam)-NH2 in combination with well-differentiated, primary cultured airway epithelial cells from wild-type and PAR2 (..
  36. Mukherjee G, Chaparro R, Schloss J, Smith C, Bando C, DiLorenzo T. Glucagon-reactive islet-infiltrating CD8 T cells in NOD mice. Immunology. 2015;144:631-40 pubmed publisher
    ..Several proteins, including those encoded by Abcc8, Atp2a2, Pcsk2, Peg3 and Scg2, were validated as antigens in this way...
  37. Janssen A, Tunster S, Savory N, Holmes A, Beasley J, Parveen S, et al. Placental expression of imprinted genes varies with sampling site and mode of delivery. Placenta. 2015;36:790-5 pubmed publisher
    ..Expression of the imprinted genes PHLDA2, CDKN1C, PEG3 and PEG10 was assayed by quantitative real time PCR. Intraplacental gene expression was analysed (N = 5)...
  38. Ye A, He H, Kim J. Paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor. PLoS ONE. 2014;9:e108596 pubmed publisher
    The expression of two adjacent imprinted genes, Peg3 and Zim1, is inversely correlated: down-regulation of Peg3 coinciding with up-regulation of Zim1...
  39. Ly L, Chan D, Aarabi M, Landry M, Behan N, MacFarlane A, et al. Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation. Mol Hum Reprod. 2017;23:461-477 pubmed publisher
    ..Transcript 1 (Non-Protein Coding)-Kcnq1ot1, Paternally Expressed Gene 1-Peg1 and Paternally Expressed Gene 3-Peg3) was assessed by luminometric methylation analysis and bisulfite pyrosequencing, respectively, in F1 sperm, F2 E18...
  40. Huang X, Shen M, Wang L, Yu F, Wu W, Liu H. Effects of tributyltin chloride on developing mouse oocytes and preimplantation embryos. Microsc Microanal. 2015;21:358-67 pubmed publisher
    ..Our results demonstrate that TBTCl treatment results in decreased mRNA levels of imprinted genes H19, Igf2r, and Peg3 during oocyte growth...
  41. Gutiérrez Zúñiga G, Hernández López J. Sensitivity improvement of a sandwich-type ELISA immunosensor for the detection of different prostate-specific antigen isoforms in human serum using electrochemical impedance spectroscopy and an ordered and hierarchically organized interfacial supram. Anal Chim Acta. 2016;902:97-106 pubmed publisher
    ..To address and minimize the issue of non-specific protein adsorption, an organic matrix (amine-PEG3-biotin/avidin) was assembled on the previously functionalized electrode surface to build up an ordered and ..
  42. Nickkholgh B, Mizrak S, van Daalen S, Korver C, Sadri Ardekani H, Repping S, et al. Genetic and epigenetic stability of human spermatogonial stem cells during long-term culture. Fertil Steril. 2014;102:1700-7.e1 pubmed publisher
    ..genes H19, H19-DMR (differentially methylated region), and MEG3 and the maternally imprinted genes KCNQ1OT1 and PEG3 were identified by means of bisulfite sequencing...
  43. Zhang X, Park J, Choi Y, Kang M, Gurunathan S, Kim J. Silver nanoparticles cause complications in pregnant mice. Int J Nanomedicine. 2015;10:7057-71 pubmed publisher
    ..5 dpc embryos and placentas, such as Ascl2, Snrpn, Kcnq1ot1, Peg3, Zac1, H19, Igf2r, and Igf2; DNA methylation studies revealed that AgNPs exposure significantly altered the ..
  44. Ye A, He H, Kim J. PEG3 binds to H19-ICR as a transcriptional repressor. Epigenetics. 2016;11:889-900 pubmed
    Paternally expressed gene 3 (Peg3) encodes a DNA-binding protein with 12 C2H2 zinc finger motifs. In the current study, we performed ChIP-seq using mouse embryonic fibroblast (MEF) cells...
  45. Yamazaki W, Amano T, Bai H, Takahashi M, Kawahara M. The Influence of Polyploidy and Genome Composition on Genomic Imprinting in Mice. J Biol Chem. 2016;291:20924-20931 pubmed
    ..The nine imprinted genes H19, Gtl2, Dlk1, Igf2r, Grb10, Zim1, Peg3, Ndn, and Ipw were all unregulated; in particular, the expression of Zim1 was more than 10-fold higher, and the ..
  46. Perera B, Kim J. Sex and Tissue Specificity of Peg3 Promoters. PLoS ONE. 2016;11:e0164158 pubmed publisher
    The expression of mouse Peg3 (Paternally expressed gene 3) is driven by 4 promoters, including its main and three alternative promoters...
  47. Sciorati C, Clementi E, Manfredi A, Rovere Querini P. Fat deposition and accumulation in the damaged and inflamed skeletal muscle: cellular and molecular players. Cell Mol Life Sci. 2015;72:2135-56 pubmed publisher
    ..These cells comprise the fibro-adipogenic precursors, the PW1-expressing cells and some interstitial cells associated with vessels (pericytes, mesoangioblasts and myoendothelial ..
  48. Xu X, Fu R, Wang L, Wang N, Zhang F, Le F, et al. Epigenetic inheritance of paternally expressed imprinted genes in the testes of ICSI mice. Curr Pharm Des. 2014;20:1764-71 pubmed
    ..Although the phenotypic abnormalities weren't found, Kcnq1ot1, Mest, Peg3, Plagl1 and Snrpn in ICSI group showed lower expressions than those in naturally conceived (NC) group...
  49. Yamazaki W, Takahashi M, Kawahara M. Restricted development of mouse triploid fetuses with disorganized expression of imprinted genes. Zygote. 2015;23:874-84 pubmed publisher
    ..86 ± 0.43 mm). In DGT fetuses, the expression level of paternally expressed genes, Igf2, Dlk1, Ndn, and Peg3, remained significantly reduced and that of maternally expressed genes, Igf2r and Grb10, increased...
  50. Li S, Pausch H, Venhoranta H, Adamowicz K, Andersson M, Zwierzchowski L, et al. PEG3 domain gene expression in maternal and foetal placenta in intrauterine growth restricted bovine foetuses. Anim Genet. 2016;47:106-9 pubmed publisher
    We used a genetic (MIMT1(Del)) model of intrauterine growth restriction to investigate dysregulation of PEG3 domain gene expression in bovine foetal and maternal placenta...
  51. Formicola L, Marazzi G, Sassoon D. The extraocular muscle stem cell niche is resistant to ageing and disease. Front Aging Neurosci. 2014;6:328 pubmed publisher
    ..PW1/Peg3 is expressed in progenitor cells in all adult tissues including satellite cells and a subset of interstitial non-..
  52. Barrow T, Barault L, Ellsworth R, Harris H, Binder A, Valente A, et al. Aberrant methylation of imprinted genes is associated with negative hormone receptor status in invasive breast cancer. Int J Cancer. 2015;137:537-47 pubmed publisher
    ..at IGF2 DMR2 were observed in 59% of cancer patients, IGF2 DMR0 in 38%, DIRAS3 DMR in 36%, GRB10 ICR in 23%, PEG3 DMR in 21%, MEST ICR in 19%, H19 ICR in 18%, KvDMR in 8% and SNRPN/SNURF ICR in 4%...
  53. Masemola M, van der Merwe L, Lombard Z, Viljoen D, Ramsay M. Reduced DNA methylation at the PEG3 DMR and KvDMR1 loci in children exposed to alcohol in utero: a South African Fetal Alcohol Syndrome cohort study. Front Genet. 2015;6:85 pubmed publisher
    ..role in growth and development and therefore four imprinting control regions (ICRs), H19 ICR, IG-DMR, KvDMR1 and PEG3 DMR were examined...
  54. Harrison K, Hoad G, Scott P, Simpson L, Horgan G, Smyth E, et al. Breast cancer risk and imprinting methylation in blood. Clin Epigenetics. 2015;7:92 pubmed publisher
    ..seven imprinted differentially methylated regions-PLAGL1/ZAC1, H19-ICR1, IGF2-DMR2, KvDMR-ICR2, RB1, SNRPN-DMR1 and PEG3-in blood samples from 189 women with the most common type of invasive breast cancer (invasive ductal carcinoma-IDC),..
  55. Bak M, Boonen S, Dahl C, Hahnemann J, Mackay D, Tumer Z, et al. Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57. BMC Med Genet. 2016;17:29 pubmed publisher
    ..at PLAGL1 have hypomethylation at additional imprinted loci throughout the genome, including GRB10, ZIM2 (PEG3), MEST (PEG1), KCNQ1OT1 and NESPAS (GNAS-AS1)...
  56. He H, Ye A, Kim H, Kim J. PEG3 Interacts with KAP1 through KRAB-A. PLoS ONE. 2016;11:e0167541 pubmed publisher
    b>Peg3 (Paternally Expressed Gene 3) is an imprinted gene that encodes a zinc finger DNA-binding protein. Peg3 itself is localized in the middle of a KRAB-A (Kruppel-Associated Box) zinc finger gene cluster...
  57. Pliushch G, Schneider E, Schneider T, El Hajj N, Rösner S, Strowitzki T, et al. In vitro maturation of oocytes is not associated with altered deoxyribonucleic acid methylation patterns in children from in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril. 2015;103:720-7.e1 pubmed publisher
    ..bisulfite pyrosequencing, we have measured average methylation levels of 6 imprinted (LIT1, MEG, MEST, NESPas, PEG3, and SNRPN), 5 tumor-suppressor (APC, ATM, BRCA1, RAD51C, and TP53), 2 pluripotency (NANOG and OCT4), and 2 ..
  58. Mai Q, Mai X, Huang X, Zhang D, Huang K, Zhou C. Imprinting Status in Two Human Parthenogenetic Embryonic Stem Cell Lines: Analysis of 63 Imprinted Gene Expression Levels in Undifferentiated and Early Differentiated Stages. Stem Cells Dev. 2018;27:430-439 pubmed publisher
    ..The four DMRs, including PEG3/ZIM2 (DMRs), SNURF/SNRPN DMRs, and KVDMR1 DMRs are highly methylated in the genes of two undifferentiated hPESCs ..
  59. Samizadeh M, Zhang X, Gunaseelan S, Nelson A, Palombo M, Myers D, et al. Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates--proof of concept for HIV mucosal pre-exposure prophylaxis. Drug Deliv Transl Res. 2016;6:1-16 pubmed publisher
    ..In MT-2 T cells, APV-PEG3.4 kDa-FITC (APF) anti-HIV-1 activity was significantly reduced (160-fold, IC50 = 8064 nM) due to poor ..
  60. Ye A, Kim H, Kim J. PEG3 control on the mammalian MSL complex. PLoS ONE. 2017;12:e0178363 pubmed publisher
    b>Peg3 (paternally expressed gene 3) encodes a DNA-binding protein that functions as a transcriptional repressor. Recent studies revealed that PEG3 binds to Msl1 (male-specific lethal 1) and Msl3, the two main components of the MSL complex...
  61. Neill T, Schaefer L, Iozzo R. Decorin as a multivalent therapeutic agent against cancer. Adv Drug Deliv Rev. 2016;97:174-85 pubmed publisher
    ..decorin initiates signaling pathways within endothelial cells downstream of VEGFR2 that ultimately culminate in a Peg3/Beclin 1/LC3-dependent autophagic program...
  62. Zhou H, Manthey J, Lioutikova E, Yang W, Yoshigoe K, Yang M, et al. The up-regulation of Myb may help mediate EGCG inhibition effect on mouse lung adenocarcinoma. Hum Genomics. 2016;10 Suppl 2:19 pubmed publisher
    ..level change caused by EGCG should be opposite to what occurred in the carcinogenesis, we identified Myb and Peg3 as the primary putative genes involved in the cancer inhibitory activity...
  63. Vidal A, Semenova V, Darrah T, Vengosh A, Huang Z, King K, et al. Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. BMC Pharmacol Toxicol. 2015;16:20 pubmed publisher
    ..03). Higher maternal blood Cd levels were also associated with lower offspring methylation at the PEG3 DMR in females (β = 0.55, se = 0.17, p = 0.05), and at the MEG3 DMR in males (β = 0.72, se = 0.3, p = 0...
  64. Kehrer J, Frischknecht F, Mair G. Proteomic Analysis of the Plasmodium berghei Gametocyte Egressome and Vesicular bioID of Osmiophilic Body Proteins Identifies Merozoite TRAP-like Protein (MTRAP) as an Essential Factor for Parasite Transmission. Mol Cell Proteomics. 2016;15:2852-62 pubmed publisher
    ..BioID of the osmiophilic body protein MDV1/PEG3 revealed a vesicular proteome of these gametocyte-specific secretory vesicles...
  65. Neill T, Torres A, Buraschi S, Iozzo R. Decorin has an appetite for endothelial cell autophagy. Autophagy. 2013;9:1626-8 pubmed publisher
    ..In our recent study, we discovered that DCN evokes synthesis of PEG3 (paternally expressed 3), an imprinted gene often silenced in various forms of cancer...
  66. Smeriglio P, Alonso Martin S, Masciarelli S, Madaro L, Iosue I, Marrocco V, et al. Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functions via epigenetic modulation of Sca-1 and Pw1 promoters. FASEB J. 2016;30:1404-15 pubmed publisher
    ..Fazi, F., Marazzi, G., Sassoon, D. A., Bouché, M. Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functionsviaepigenetic modulation of Sca-1 and Pw1 promoters.
  67. Patiño Parrado I, Gómez Jiménez Á, López Sánchez N, Frade J. Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting. Nucleic Acids Res. 2017;45:8822-8834 pubmed publisher
    ..characterized by strand-specific hemimethylation of contiguous CpG sites affecting the germline DMR of the murine Peg3, but not Snrpn, imprinted domain...
  68. Skiles W, Kester A, Pryor J, Westhusin M, Golding M, Long C. Oxygen-induced alterations in the expression of chromatin modifying enzymes and the transcriptional regulation of imprinted genes. Gene Expr Patterns. 2018;28:1-11 pubmed publisher
    ..were associated with alterations in the control of multiple imprinted genes, including H19, Igf2, Igf2r, and Peg3. Similarly, exposure of in vitro produced bovine embryos to atmospheric oxygen concentrations was associated with ..
  69. Klimczak A, Kozlowska U, Kurpisz M. Muscle Stem/Progenitor Cells and Mesenchymal Stem Cells of Bone Marrow Origin for Skeletal Muscle Regeneration in Muscular Dystrophies. Arch Immunol Ther Exp (Warsz). 2018;66:341-354 pubmed publisher
    ..satellite cells and non-satellite stem cells including MSCs, interstitial stem cells positive for stress mediator PW1 expression and negative for PAX7 called PICs (PW1+/PAX7- interstitial cells), fibro/..
  70. Kim J, Bretz C, Lee S. Epigenetic instability of imprinted genes in human cancers. Nucleic Acids Res. 2015;43:10689-99 pubmed publisher
    ..These changes are also accompanied by DNA methylation level changes in several imprinted domains, such as the PEG3, MEST and GNAS domains...
  71. Frey W, Kim J. Tissue-Specific Contributions of Paternally Expressed Gene 3 in Lactation and Maternal Care of Mus musculus. PLoS ONE. 2015;10:e0144459 pubmed publisher
    Paternally Expressed Gene 3 (Peg3) is an imprinted gene that controls milk letdown and maternal-caring behaviors...
  72. Douglass S, Goyal A, Iozzo R. The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy. Connect Tissue Res. 2015;56:381-91 pubmed publisher
    ..A novel and emerging role of endorepellin is its ability to evoke autophagy by activating Peg3 and various canonical autophagic markers...
  73. Liang F, Diao L, Jiang N, Zhang J, Wang H, Zhou W, et al. Chronic exposure to ethanol in male mice may be associated with hearing loss in offspring. Asian J Androl. 2015;17:985-90 pubmed publisher
    ..The methylation of H19, Peg3, Ndn and Snrpn was assessed in paternal spermatozoa and in the cerebral cortices of deaf mice...
  74. Garvilles R, Hasegawa T, Kimura H, Sharif J, Muto M, Koseki H, et al. Dual Functions of the RFTS Domain of Dnmt1 in Replication-Coupled DNA Methylation and in Protection of the Genome from Aberrant Methylation. PLoS ONE. 2015;10:e0137509 pubmed publisher
    ..DNA methylation of the differentially methylated regions of three imprinted genes, Kcnq1ot1/Lit1, Peg3, and Rasgrf1, was impaired in cells expressing the Dnmt1 with not the PCNA-binding domain alone but both the PCNA-..
  75. Malinverno M, Corada M, Ferrarini L, Formicola L, Marazzi G, Sassoon D, et al. Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors. Stem Cells. 2017;35:1328-1340 pubmed publisher
    ..In this group, we then concentrated on the progenitor cell marker Peg3/PW1...
  76. Kaneda M, Watanabe S, Akagi S, Inaba Y, Geshi M, Nagai T. Proper reprogramming of imprinted and non-imprinted genes in cloned cattle gametogenesis. Anim Sci J. 2017;88:1678-1685 pubmed publisher
    ..To test this hypothesis in cloned cattle, we compared the DNA methylation level of two imprinted genes (H19 and PEG3) and three non-imprinted genes (XIST, OCT4 and NANOG) and two repetitive elements (Satellite I and Satellite II) in ..
  77. Minamimoto R, Jamali M, Barkhodari A, Mosci C, Mittra E, Shen B, et al. Biodistribution of the ¹⁸F-FPPRGD₂ PET radiopharmaceutical in cancer patients: an atlas of SUV measurements. Eur J Nucl Med Mol Imaging. 2015;42:1850-8 pubmed publisher
    ..the biodistribution of 2-fluoropropionyl-labeled PEGylated dimeric arginine-glycine-aspartic acid (RGD) peptide (PEG3-E[c{RGDyk}]2) ((18)F-FPPRGD2) in cancer patients and to compare its uptake in malignant lesions with (18)F-FDG ..
  78. Lee S, Ye A, Kim J. DNA-Binding Motif of the Imprinted Transcription Factor PEG3. PLoS ONE. 2015;10:e0145531 pubmed publisher
    b>Peg3 is an imprinted gene that is predicted to encode a DNA-binding zinc finger protein. This was previously demonstrated through Chromatin ImmunoPrecipitation-based Sequencing experiments...
  79. Yuan B, Gu H, Xu B, Tang Q, Wu W, Ji X, et al. Effects of Gold Nanorods on Imprinted Genes Expression in TM-4 Sertoli Cells. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..We found significantly diminished expression of Kcnq1, Ntm, Peg10, Slc22a2, Pwcr1, Gtl2, Nap1l5, Peg3 and Slc22a2, while Plagl1 was significantly overexpressed...
  80. Sojoodi M, Stradiot L, Tanaka K, Heremans Y, Leuckx G, Besson V, et al. The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling. Diabetologia. 2016;59:1474-1479 pubmed publisher
    Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult...
  81. Cottle B, Lewis F, Shone V, Ellison Hughes G. Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing, and multi-potent in vitro and in vivo. Stem Cell Res Ther. 2017;8:158 pubmed publisher
    ..This study investigated the potential of muscle-derived PW1+/Pax7- interstitial progenitor cells (PICs) as a source of tissue-specific stem/progenitor ..
  82. Yao Y, Norris E, Mason C, Strickland S. Laminin regulates PDGFR?(+) cell stemness and muscle development. Nat Commun. 2016;7:11415 pubmed publisher
    Muscle-resident PDGFR?(+) cells, which include pericytes and PW1(+) interstitial cells (PICs), play a dual role in muscular dystrophy...
  83. He H, Perera B, Ye A, Kim J. Parental and sexual conflicts over the Peg3 imprinted domain. Sci Rep. 2016;6:38136 pubmed publisher
    In the current study, the imprinting control region of the mouse Peg3 domain was deleted to test its functional impact on animal growth and survival...
  84. Correa E, da Silva W, P Barreto P, Albernaz A. Theoretical study of the H + HCN → H + HCN process. J Mol Model. 2017;23:169 pubmed publisher
    ..Three different pathways (PW1, PW2, and PW3) were analyzed and the results from the potential energy surface calculations were used to solve the ..
  85. Denizot A, Besson V, Correra R, Mazzola A, Lopes I, Courbard J, et al. A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior. PLoS Genet. 2016;12:e1006053 pubmed publisher
    ..The mutant phenotype of the imprinted gene, Pw1/Peg3, provides a key example to illustrate the hypothesis on a coadaptation between mother and offspring, in which Pw1/..
  86. Mitchell M, Strick R, Strissel P, Dittrich R, McPherson N, Lane M, et al. Gene expression and epigenetic aberrations in F1-placentas fathered by obese males. Mol Reprod Dev. 2017;84:316-328 pubmed publisher
    ..gene family, we observed a significant effect of paternal diet-induced obesity on deregulated expression of Peg3, Peg9, Peg10, and the nutrient transporter gene Slc38a2, and aberrant DNA methylation of the Peg9 promoter in F1 ..
  87. Neill T, Sharpe C, Owens R, Iozzo R. Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy. J Biol Chem. 2017;292:16211-16220 pubmed publisher
    ..autophagic program downstream of VEGF receptor 2 (VEGFR2) signaling that requires paternally expressed gene 3 (PEG3)...
  88. Gibson C, de Ruijter Villani M, Stout T. Negative uterine asynchrony retards early equine conceptus development and upregulation of placental imprinted genes. Placenta. 2017;57:175-182 pubmed publisher
    ..Maternal (GRB10, H19, IGF2R, PHLDA2) and paternal (IGF2, INSR, PEG3, PEG10, DIO3, NDN, SNRPN) imprinted genes and DNMTs (DNMT1, 3A and 3B) were all up-regulated between day 14 and 19 ..
  89. Yarden R, Brody L. Identification of proteins that interact with BRCA1 by Far-Western library screening. J Cell Biochem. 2001;83:521-31 pubmed
    ..We isolated eight cDNAs that bind to the BRCT domain of BRCA1. Further analysis demonstrated that two of the clones encode for proteins that interact directly with the BRCT domain of BRCA1. ..
  90. Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens R, et al. Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A. 2013;110:E2582-91 pubmed publisher
    ..We found that decorin induced paternally expressed gene 3 (Peg3), an imprinted tumor suppressor gene, and that Peg3 relocated into autophagosomes labeled by Beclin 1 and ..
  91. Bonfanti C, Rossi G, Tedesco F, Giannotta M, Benedetti S, Tonlorenzi R, et al. PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence. Nat Commun. 2015;6:6364 pubmed publisher
    ..Here we show that PW1/Peg3 is expressed at high levels in mesoangioblasts obtained from mouse, dog and human tissues and its level of ..
  92. Kim J, Ye A. Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain. PLoS ONE. 2016;11:e0154216 pubmed publisher
    The Peg3 (Paternally Expressed Gene 3) imprinted domain is predicted to be regulated through a large number of evolutionarily conserved regions (ECRs) that are localized within its middle 200-kb region...