Gene Symbol: PECR
Description: peroxisomal trans-2-enoyl-CoA reductase
Alias: DCRRP, HPDHASE, HSA250303, PVIARL, SDR29C1, TERP, peroxisomal trans-2-enoyl-CoA reductase, 2,4-dienoyl-CoA reductase-related protein, DCR-RP, pVI-ARL, short chain dehydrogenase/reductase family 29C member 1
Species: human
Products:     PECR

Top Publications

  1. Wong N, Liu X, Lloyd H, Colthart A, Ferrazzoli A, Cooper D, et al. A new approach to understanding structure-function relationships in cytochromes P450 by targeting terpene metabolism in the wild. J Inorg Biochem. 2018;188:96-101 pubmed publisher
    ..Shotgun sequencing of PnTPJM identified four candidate P450 genes, including an apparently fragmentary gene with a high degree of homology with the known enzyme CYP108 (P450terp).
  2. Liu K, Aggarwal P, Tolley H, Lawson J, Lee M. Fabrication of highly cross-linked reversed-phase monolithic columns via living radical polymerization. J Chromatogr A. 2014;1367:90-8 pubmed publisher
    ..tetraacrylate (PETA)] were synthesized using organotellurium-mediated living radical polymerization (TERP), which was expected to produce more efficient monolithic columns than conventional free-radical polymerization...
  3. Singh G, Sarkar N, Grover A. Mapping of domains of heat stress transcription factor OsHsfA6a responsible for its transactivation activity. Plant Sci. 2018;274:80-90 pubmed publisher
    ..The results obtained in yeast were complemented with transient expression of reporter in protoplast (TERP) based assay...
  4. Stuczyńska A, Piórkowska K, Tyra M, Zukowski K. The effect of QTL-rich region polymorphisms identified by targeted DNA-seq on pig production traits. Mol Biol Rep. 2018;45:361-371 pubmed publisher
    The aim of the present study was to analyse the effect of PLCD4, PECR, FN1 and PNKD mutations on pig productive traits and tested the usefulness of targeted enrichment DNA sequencing method as tool for preselection of genetic markers...
  5. Liu Z, Geng Y, Wang H, Sun L, Ma Z, Tian X, et al. Emergy-based comparative analysis of energy intensity in different industrial systems. Environ Sci Pollut Res Int. 2015;22:18687-98 pubmed publisher
    ..PEC) of DEDA was much higher than that of FETA during 2006 to 2010 and its primary energy consumption ratio (PECR) to total emergy involvement had a dramatically decline from year 2006 to 2010...
  6. Ameen D, Michniak Kohn B. Transdermal delivery of dimethyl fumarate for Alzheimer's disease: Effect of penetration enhancers. Int J Pharm. 2017;529:465-473 pubmed publisher
    ..80 (T80), N-methyl pyrrolidone (NMP), laurocapram (Azone®) (Az), Transcutol P (Tc), Terpineol (Terp), and cineole (Cin) using vertical Franz diffusion cells and human cadaver skin...
  7. Loutchanwoot P, Vortherms T, Jarry H. Evaluation of in vivo estrogenic potency of natural estrogen-active chemical, puerarin, on pituitary function in gonadectomized female rats. Life Sci. 2016;165:75-82 pubmed publisher
    ..genes, such as estrogen receptor (ER) subtypes alpha (ER?) and beta (ER?), truncated ER product-1 (TERP-1) and -2 (TERP-2) and gonadotropin alpha subunit, were examined using radioimmunoassay and TaqMan® real-time PCR, ..
  8. Brabec V, Pracharova J, Stepankova J, Sadler P, Kasparkova J. Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex. J Inorg Biochem. 2016;160:149-55 pubmed publisher
    We report DNA cleavage by ruthenium(II) arene anticancer complex [(η(6)-p-terp)Ru(II)(en)Cl](+) (p-terp=para-terphenyl, en=1,2-diaminoethane, complex 1) after its photoactivation by UVA and visible light, and the toxic effects of ..
  9. Grando T, Baldissera M, Gressler L, de Sa M, Bortoluzzi B, Schafer A, et al. Melaleuca alternifolia anthelmintic activity in gerbils experimentally infected by Haemonchus contortus. Exp Parasitol. 2016;170:177-183 pubmed publisher tea tree oil (TTO), a solid lipid nanocarrier made with essential oil of Melaleuca (nanoTTO), and terpinen-4-ol (terp-4-ol). In vivo studies were performed by determining the mean worm burden of H. contortus in gerbils TTO (0...

More Information


  1. Furfari A, Wan B, Ding K, Wong A, Zhu L, Bezjak A, et al. Genetic biomarkers associated with pain flare and dexamethasone response following palliative radiotherapy in patients with painful bone metastases. Ann Palliat Med. 2017;6:S240-S247 pubmed publisher
    ..Significant SNVs associated with pain flare were found in genes with functions in biosynthesis (DHODH, PECR), lipid excretion and metabolism (UGT2A1/2, VLDLR), and intracellular signalling (DNM2, SEC23A)...
  2. Gloerich J, Ruiter J, van den Brink D, Ofman R, Ferdinandusse S, Wanders R. Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. FEBS Lett. 2006;580:2092-6 pubmed
    ..In conclusion, our results show that human TER is responsible for the reduction of phytenoyl-CoA to phytanoyl-CoA in peroxisomes. ..
  3. Gay F, Anglade I, Gong Z, Salbert G. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol Endocrinol. 2000;14:1627-48 pubmed
    ..Taken together, these data suggest that ISL1-ER cross-talk could differentially regulate the expression of ER and ISL1 target genes. ..
  4. Hersh C, Pillai S, Zhu G, Lomas D, Bakke P, Gulsvik A, et al. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Am J Respir Crit Care Med. 2010;182:605-13 pubmed publisher
    ..By combining data from COPD genetic association studies conducted in four independent patient samples, we have identified XRCC5, an ATP-dependent DNA helicase, as a potential COPD susceptibility gene. ..
  5. D Agosto F, Wolpers A, Ebeling B, Nakamura Y, Yamago S, Monteil V. Controlled radical polymerization of ethylene using organotellurium compounds. Angew Chem Int Ed Engl. 2017;: pubmed publisher
    ..conditions (70 °C, 200 bar of ethylene) within the concept of organotellurium-mediated radical polymerization (TERP)...
  6. Treutlein J, Cichon S, Ridinger M, Wodarz N, Soyka M, Zill P, et al. Genome-wide association study of alcohol dependence. Arch Gen Psychiatry. 2009;66:773-84 pubmed publisher
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  7. Braastad C, Leguia M, Hendrickson E. Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. Nucleic Acids Res. 2002;30:1713-24 pubmed
    ..These data expand our understanding of this important DNA repair locus. ..
  8. Hua T, Wu D, Ding W, Wang J, Shaw N, Liu Z. Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal ?-oxidation of unsaturated fatty acids. J Biol Chem. 2012;287:28956-65 pubmed publisher
    ..Unlike mDCR, hinge movements permit pDCR to process very long chain polyunsaturated fatty acids. ..
  9. Das A, Uhler M, Hajra A. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. J Biol Chem. 2000;275:24333-40 pubmed publisher
    ..Northern blot analysis demonstrated that a single transcript of 1.3 kilobases is present in most mouse tissues, with particularly high concentrations in liver and kidney...
  10. Amery L, Mannaerts G, Subramani S, Van Veldhoven P, Fransen M. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. Comb Chem High Throughput Screen. 2001;4:545-52 pubmed
    ..These results further demonstrate the suitability of the gVI-cDNA phage display technology for cDNA expression cloning using an antibody as a probe. ..