Gene Symbol: PECAM 1
Description: platelet and endothelial cell adhesion molecule 1
Alias: CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet endothelial cell adhesion molecule, CD31 antigen, platelet endothelial cell adhesion molecule-1
Species: human
Products:     PECAM 1

Top Publications

  1. Stockinger H, Gadd S, Eher R, Majdic O, Schreiber W, Kasinrerk W, et al. Molecular characterization and functional analysis of the leukocyte surface protein CD31. J Immunol. 1990;145:3889-97 pubmed
    The CD31 Ag is a surface glycoprotein of 130 kDa with a broad cellular distribution. We show that among peripheral human blood cells, it is expressed on monocytes, granulocytes, platelets, and a subpopulation of lymphocytes...
  2. Akers S, O Leary H, Minnear F, Craig M, Vos J, Coad J, et al. VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers. Exp Hematol. 2010;38:733-43 pubmed publisher
    ..on the contribution of the unique coexpression of vascular endothelial (VE)-cadherin and platelet endothelial cell adhesion molecule-1 (PECAM-1) by ALL in mediating leukemic cell interactions with HBMEC as an in vitro model of ..
  3. Dhanjal T, Ross E, Auger J, McCarty O, Hughes C, Senis Y, et al. Minimal regulation of platelet activity by PECAM-1. Platelets. 2007;18:56-67 pubmed
  4. Lee F, van Lier M, Relou I, Foley L, Akkerman J, Heijnen H, et al. Lipid rafts facilitate the interaction of PECAM-1 with the glycoprotein VI-FcR gamma-chain complex in human platelets. J Biol Chem. 2006;281:39330-8 pubmed
    ..We propose that lipid raft clustering facilitates the interaction of PECAM-1 with the GPVI-FcR gamma-chain complex, leading to the down-regulation of the latter. ..
  5. Pajusto M, Tarkkanen J, Mattila P. Platelet endothelial cell adhesion molecule-1 is expressed in adenoidal crypt epithelial cells. Scand J Immunol. 2005;61:82-6 pubmed
    ..possibly mediate leucocyte infiltration, expressions of leucocyte adhesion molecules, such as platelet endothelial cell adhesion molecule-1 (PECAM-1) (CD31), vascular cell adhesion molecule-1 (VCAM-1) (CD106) and intercellular ..
  6. Ilan N, Madri J. PECAM-1: old friend, new partners. Curr Opin Cell Biol. 2003;15:515-24 pubmed
    The maintenance of vascular function is of paramount importance to an organism's existence. PECAM-1 (CD31), first thought of as a marker for endothelia, has been shown to be an important scaffolding molecule involved in several signaling ..
  7. Righi L, Deaglio S, Pecchioni C, Gregorini A, Horenstein A, Bussolati G, et al. Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells. Am J Pathol. 2003;162:1163-74 pubmed
    ..Our finding that a subset of these tumors express CD31/platelet endothelial cell adhesion molecule-1 suggests that breast cancer represents an informative model for studying the involvement of ..
  8. Newton J, Hunter A, Simmons D, Buckley C, Harvey D. CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylated. Biochem Biophys Res Commun. 1999;261:283-91 pubmed
    b>CD31 (PECAM-1) is a highly abundant cell surface glycoprotein expressed on hemopoietic and endothelial cells where it functions as a homophilic adhesion and signaling receptor...
  9. Kirschbaum N, Gumina R, Newman P. Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain. Blood. 1994;84:4028-37 pubmed
    b>Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell-cell adhesion molecule that is expressed on circulating platelets, on leukocytes, and at the intercellular junctions of vascular endothelial cells and mediates the ..

More Information


  1. Jackson D, Kupcho K, Newman P. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2. J Biol Chem. 1997;272:24868-75 pubmed
    ..Together, these data provide a molecular model for PECAM-1/SHP-2 interactions that may shed light on the downstream events that follow PECAM-1-mediated interactions of vascular cells. ..
  2. Deaglio S, Aydin S, Grand M, Vaisitti T, Bergui L, D Arena G, et al. CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells. Mol Med. 2010;16:87-91 pubmed publisher
    ..CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) ..
  3. Sandlund J, Hedberg Y, Bergh A, Grankvist K, Ljungberg B, Rasmuson T. Evaluation of CD31 (PECAM-1) expression using tissue microarray in patients with renal cell carcinoma. Tumour Biol. 2007;28:158-64 pubmed
    ..the prognostic information of MVD in renal cell carcinoma (RCC) we assessed the immunohistochemical expression of CD31 in 208 tumours using the tissue microarray technique...
  4. Ilan N, Cheung L, Pinter E, Madri J. Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation. J Biol Chem. 2000;275:21435-43 pubmed
    ..These data further support the concept that PECAM-1 functions as a binder and modulator of catenins and provides a molecular mechanism for previously reported PECAM-1/cytoskeleton interactions. ..
  5. Cicmil M, Thomas J, Sage T, Barry F, Leduc M, Bon C, et al. Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases. J Biol Chem. 2000;275:27339-47 pubmed
    b>Platelet endothelial cell adhesion molecule-1 (CD31) is a 130-kDa glycoprotein receptor present on the surface of platelets, neutrophils, monocytes, certain T-lymphocytes, and vascular endothelial cells...
  6. Tang D, Chen Y, Newman P, Shi L, Gao X, Diglio C, et al. Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium. J Biol Chem. 1993;268:22883-94 pubmed
    PECAM-1 (CD31/EndoCAM) is an adhesion molecule in the immunoglobulin supergene family that is expressed on endothelial cells, platelets, and some hematopoietic lineage cells...
  7. Jackson D. The unfolding tale of PECAM-1. FEBS Lett. 2003;540:7-14 pubmed
    b>Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is a member of the immunoglobulin (Ig) superfamily that has distinctive features of an immunoreceptor based upon its genomic structure and the presence of intrinsic ..
  8. Lu T, Yan L, Madri J. Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Proc Natl Acad Sci U S A. 1996;93:11808-13 pubmed
    Platelet-endothelial cell adhesion molecule 1 (PECAM-1, CD31) is a 130-kDa member of the immunoglobulin gene superfamily expressed on endothelial cells, platelets, neutrophils, and monocytes and plays a role during endothelial cell ..
  9. Albelda S, Muller W, Buck C, Newman P. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol. 1991;114:1059-68 pubmed a member of the immunoglobulin gene superfamily and that antibodies against the bovine form of this protein (endoCAM) can inhibit endothelial cell-cell interactions...
  10. Kim M, Jin E, Zhang H, Kim S. Robust angiogenic properties of cultured human peripheral blood-derived CD31? cells. Int J Cardiol. 2013;166:709-15 pubmed publisher
    Recently, we showed the angio-vasculogenic potential of uncultured human peripheral blood (hPB)-derived CD31(+) cells. However, thus far, the angiogenic property of the cultured hPB-derived CD31(+) (C-31(+)) cells is unknown...
  11. Tonino S, Spijker R, Luijks D, van Oers M, Kater A. No convincing evidence for a role of CD31-CD38 interactions in the pathogenesis of chronic lymphocytic leukemia. Blood. 2008;112:840-3 pubmed publisher
    ..Interaction with its proposed ligand CD31 expressed on nurse-like cells would result in proliferative and survival-signals...
  12. Lutzky V, Carnevale R, Alvarez M, Maffia P, Zittermann S, Podhajcer O, et al. Platelet-endothelial cell adhesion molecule-1 (CD31) recycles and induces cell growth inhibition on human tumor cell lines. J Cell Biochem. 2006;98:1334-50 pubmed
    b>CD31 (PECAM-1) is a 130-kDa member of the immunoglobulin gene superfamily expressed on endothelial cells, platelets, and most leukocytes...
  13. Cao M, Huber M, Beauchemin N, Famiglietti J, Albelda S, Veillette A. Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J Biol Chem. 1998;273:15765-72 pubmed
  14. Casals Pascual C, Allen S, Allen A, Kai O, Lowe B, Pain A, et al. Short report: codon 125 polymorphism of CD31 and susceptibility to malaria. Am J Trop Med Hyg. 2001;65:736-7 pubmed
    Platelet-endothelial cell adhesion molecule 1 (PECAM-1/CD31) has been identified as an endothelial cell receptor of Plasmodium falciparum-infected erythrocytes...
  15. Lu T, Barreuther M, Davis S, Madri J. Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties. J Biol Chem. 1997;272:14442-6 pubmed
    b>Platelet endothelial cell adhesion molecule-1 (PECAM-1) is 130-kDa member of the immunoglobulin gene superfamily that localizes to cell-cell borders of confluent endothelial cells and has been shown to play a role in the control of ..
  16. Newman P, Berndt M, Gorski J, White G, Lyman S, Paddock C, et al. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. 1990;247:1219-22 pubmed
    An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular ..
  17. Newman P, Newman D. Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology. Arterioscler Thromb Vasc Biol. 2003;23:953-64 pubmed
    Recent studies of platelet endothelial cell adhesion molecule-1 (PECAM-1 [CD31])-deficient mice have revealed that this molecule plays an important role in controlling the activation and survival of cells on which it is expressed...
  18. Behar E, Chao N, Hiraki D, Krishnaswamy S, Brown B, Zehnder J, et al. Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease. N Engl J Med. 1996;334:286-91 pubmed
    ..We sought to determine whether the CD31 adhesion molecule is a minor alloantigen...
  19. Pellegatta F, Chierchia S, Zocchi M. Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils. J Biol Chem. 1998;273:27768-71 pubmed
    In this paper we show that the engagement of the platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) up-regulates the adhesion of human neutrophils to the EA...
  20. Kikuchi M, Looareesuwan S, Ubalee R, Tasanor O, Suzuki F, Wattanagoon Y, et al. Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais. Parasitol Int. 2001;50:235-9 pubmed
    ..PECAM-1/CD31 is one of these candidate ligands and is coded by a polymorphic gene...
  21. Tai L, Zheng Q, Pan S, Jin Z, Berk B. Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2. J Biol Chem. 2005;280:29620-4 pubmed
    ..These results establish Tie2 transactivation via PECAM1 as an early event in flow-mediated mechanotransduction and suggest an important role for a PECAM1-SHP2-Tie2 pathway in flow-mediated signal transduction. ..
  22. Jones C, Garner S, Moraes L, Kaiser W, Rankin A, Ouwehand W, et al. PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways. FEBS Lett. 2009;583:3618-24 pubmed publisher
    b>Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored...
  23. Zhao T, Newman P. Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell. J Cell Biol. 2001;152:65-73 pubmed
    b>Platelet endothelial cell adhesion molecule (PECAM)-1 is a 130-kD transmembrane glycoprotein having six Ig homology domains within its extracellular domain and an immunoreceptor tyrosine-based inhibitory motif within its cytoplasmic ..
  24. Bergom C, Goel R, Paddock C, Gao C, Newman D, Matsuyama S, et al. The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy. Cancer Biol Ther. 2006;5:1699-707 pubmed
    ..In addition, reducing PECAM-1 levels in the tumor endothelium may aid in low-dose, anti-angiogenic therapy. ..
  25. Jackson D, Ward C, Wang R, Newman P. The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular s. J Biol Chem. 1997;272:6986-93 pubmed
  26. Gao C, Sun W, Christofidou Solomidou M, Sawada M, Newman D, Bergom C, et al. PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis. Blood. 2003;102:169-79 pubmed
    ..Here we show that platelet endothelial cell adhesion molecule-1 (PECAM-1), a homophilic-binding member of the immunoreceptor tyrosine-based inhibitory motif (..
  27. Ferrero E, Belloni D, Contini P, Foglieni C, Ferrero M, Fabbri M, et al. Transendothelial migration leads to protection from starvation-induced apoptosis in CD34+CD14+ circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation. Blood. 2003;101:186-93 pubmed
    ..Interestingly, ligation of the platelet endothelial cell adhesion molecule-1 (PECAM-1), which drives CD14(+)CD34(+) transendothelial migration, leads to an increase in ..
  28. Amodu O, Gbadegesin R, Ralph S, Adeyemo A, Brenchley P, Ayoola O, et al. Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria?. Acta Trop. 2005;95:248-55 pubmed
    ..Further studies of host loci are needed to further delineate which polymorphisms are associated with severe malaria and increase our knowledge of the biology of host-parasite interactions. ..
  29. Listi F, Candore G, Lio D, Cavallone L, Colonna Romano G, Caruso M, et al. Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily. Eur J Immunogenet. 2004;31:175-8 pubmed
    ..Platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31), involved in this migration, has been associated with the developmental course of atherosclerosis...
  30. Hata K, Maeno Hikichi Y, Yumoto N, Burden S, Landmesser L. Distinct Roles of Different Presynaptic and Postsynaptic NCAM Isoforms in Early Motoneuron-Myotube Interactions Required for Functional Synapse Formation. J Neurosci. 2018;38:498-510 pubmed publisher
    ..Our identification of novel roles for NCAM and Lrp4 and possible interactions between them in transforming motile growth cones into stable contacts opens interesting new avenues for exploration. ..
  31. Mishra R, Roux B, Posukonis M, Bodamer E, Brey E, Fisher J, et al. Effect of prevascularization on in vivo vascularization of poly(propylene fumarate)/fibrin scaffolds. Biomaterials. 2016;77:255-66 pubmed publisher
    ..During in vitro studies, CD31 staining showed a significant increase in vascular network area over 3 weeks of culture...
  32. Hirano Y, Kobayashi K, Tomiki H, Inaba Y, Ichikawa M, Kim B, et al. The role of ?4 integrin in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease: an infectious animal model for multiple sclerosis (MS). Int Immunol. 2016;28:575-584 pubmed publisher
    ..05). HCA3551 treatment in the effector phase might inhibit the binding of ?4 integrin to vascular cell adhesion molecule-1, thereby decreasing the number of mononuclear cells in the CNS. ..
  33. Segal D, Dhanyasi N, Schejter E, Shilo B. Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia. Dev Cell. 2016;38:291-304 pubmed publisher
    ..We therefore propose that the filopodia are necessary to prime the heterotypic adhesion process between the two cell types, possibly by recruiting the cell-adhesion molecule Sns to discrete patches on the myoblast cell surface. ..
  34. Lee H, Park S, Park D. Novel treatments for inflammatory bowel disease. Korean J Intern Med. 2017;: pubmed publisher
    ..These agents will likely expand the treatment options available for the management of IBD patients in the future. In this review, we discuss the efficacy and safety of novel agents currently under investigation in IBD clinical trials...
  35. Suzuki Y, Nishio K, Takeshita K, Takeuchi O, Watanabe K, Sato N, et al. Effect of steroid on hyperoxia-induced ICAM-1 expression in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L245-52 pubmed
    ..These results suggest that MP downregulates hyperoxia-induced ICAM-1 expression by inhibiting NF-kappaB activation via increased IkappaB-alpha expression...
  36. Gao C, Ding P, Yang L, He X, Chen M, Wang D, et al. Oxymatrine Sensitizes the HaCaT Cells to the IFN-γ Pathway and Downregulates MDC, ICAM-1, and SOCS1 by Activating p38, JNK, and Akt. Inflammation. 2018;41:606-613 pubmed publisher
    ..Thus, the mechanisms through which OMT and FK506 ameliorate allergic skin diseases differ. ..
  37. Musumeci G, Castorina A, Magro G, Cardile V, Castorina S, Ribatti D. Enhanced expression of CD31/platelet endothelial cell adhesion molecule 1 (PECAM1) correlates with hypoxia inducible factor-1 alpha (HIF-1α) in human glioblastoma multiforme. Exp Cell Res. 2015;339:407-16 pubmed publisher
    ..In this study we have investigated whether the expression levels of CD31/ PECAM1 are deregulated in human GBM tissue specimens and we have also correlated the expression levels of CD31/..
  38. Pérez S, Pereda J, Sabater L, Sastre J. Pancreatic ascites haemoglobin up-regulates the HIF/VEGF pathway in the lung in severe acute pancreatitis. Free Radic Biol Med. 2014;75 Suppl 1:S44 pubmed publisher
    ..In conclusion, extracellular hemoglobin contributes to the inflammatory response in severe acute pancreatitis through abdominal fat necrosis and inflammation and increasing VEGF and leukocyte infiltration in the lung. ..
  39. Wang X, Liu M, Sun X, Xu C, Liu J, Chen J, et al. TGF-β1 pathway affects the protein expression of many signaling pathways, markers of liver cancer stem cells, cytokeratins, and TERT in liver cancer HepG2 cells. Tumour Biol. 2016;37:3675-81 pubmed publisher
    ..These data will contribute to the understanding of the pathogenesis of liver cancer and the role of TGF-β pathway in this process. ..
  40. Zhu Y, Qu N, Sun L, Meng X, Li X, Zhang Y. Solitary pulmonary capillary hemangioma presents as ground glass opacity on computed tomography indicating adenocarcinoma in situ/atypical adenomatous hyperplasia: A case report. Biomed Rep. 2017;7:515-519 pubmed publisher
    ..Immunohistochemical staining revealed that the flat cells were positive for cluster of differentiation CD31 and CD34, and negative for thyroid transcription factor-1 and cytokeratin...
  41. Neil D. CD31 highlights platelet-rich microthrombi. Histopathology. 2009;54:387-8 pubmed publisher
  42. Kulkarni M, Bowman E, Gabriel J, Amburgy T, Mayne E, Zidar D, et al. Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection. Open Forum Infect Dis. 2016;3:ofw224 pubmed publisher
    ..05 for all). Increased proportions of CD16+ monocytes, cells with altered adhesion molecule expression, combined with elevated levels of their ligands, may promote vascular inflammation in HIV infection. ..
  43. Iannacone M. Platelet-mediated modulation of adaptive immunity. Semin Immunol. 2016;28:555-560 pubmed publisher
    ..By using mouse models of viral hepatitis as a paradigmatic example, we will review here how platelets coordinate adaptive immune responses and suggest possible clinical implications. ..
  44. DI D, Chen L, Wang L, Wang C, Ju J. [Down-regulation of human intercellular adhesion molecule-1 expression in MCF-7 cells infected by lentiviral short hairpin RNA interference vectors]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:1048-52 pubmed
    ..Lentiviral interference vectors of human ICAM-1 were constructed successfully and the expression of ICAM-1 in MCF-7 cells was down-regulated by ICAM-1 shRNA. ..
  45. Ji M, Wang Y, Wang L, Chen L, Li J. Protective effect of Xuebijing injection against acute lung injury induced by left ventricular ischemia/reperfusion in rabbits. Exp Ther Med. 2016;12:51-58 pubmed
    ..These results suggest that XBJ may protect against left ventricular I/R-induced ALI by regulating the expression of the inflammatory mediators TNF-? and ICAM-1. ..
  46. Namgung S, Yoon J, Yoon C, Han B, Choi E, Oh H, et al. Prunella vulgaris Attenuates Diabetic Renal Injury by Suppressing Glomerular Fibrosis and Inflammation. Am J Chin Med. 2017;45:475-495 pubmed publisher
    ..Therefore, APV may be useful in potential therapies that target glomerulonephritis and glomerulosclerosis, which lead to diabetic nephropathy. ..
  47. Zhang Y, Sui F, Ma J, Ren X, Guan H, Yang Q, et al. Positive Feedback Loops Between NrCAM and Major Signaling Pathways Contribute to Thyroid Tumorigenesis. J Clin Endocrinol Metab. 2017;102:613-624 pubmed publisher
  48. Tanaka Y, Aishima S, Kohashi K, Okumura Y, Wang H, Hida T, et al. Spalt-like transcription factor 4 immunopositivity is associated with epithelial cell adhesion molecule expression in combined hepatocellular carcinoma and cholangiocarcinoma. Histopathology. 2016;68:693-701 pubmed publisher
    ..Further study is necessary to interpret the immunostaining pattern for SALL4. ..
  49. Yin L, Duan T, Ulloa L, Yang Y. Ezrin Orchestrates Signal Transduction in Airway Cells. Rev Physiol Biochem Pharmacol. 2018;174:1-23 pubmed publisher
    ..These studies provide new insights for the design of novel therapeutic strategies for asthma treatment. ..
  50. Przhiialkovskaia E, Abrosimov A, Grigor ev A, Marova E, Rozhinskaia L. [Prognostic value of of the expression Ki-67, CD31, and VEGF in somatotropinomas]. Arkh Patol. 2010;72:35-8 pubmed analyze the prognostic value of immunoexpression of the proliferation marker Ki-67 and the angiogenetic factors CD31 and VEGF in somatotropinomas...
  51. Kim W, Ma L, Lomoio S, Willen R, Lombardo S, Dong J, et al. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener. 2018;13:6 pubmed publisher
    ..Therefore, therapeutic approaches aimed to restore GGA3 function and to prevent the down stream effects of its depletion (e.g. BACE1 elevation) represent an attractive alternative to BACE inhibition for the prevention/treatment of AD. ..
  52. Cui D, Li H, Lei L, Chen C, Yan F. Nonsurgical periodontal treatment reduced aortic inflammation in ApoE(-/-) mice with periodontitis. Springerplus. 2016;5:940 pubmed publisher
  53. McClung J, McCord T, Southerland K, Schmidt C, Padgett M, Ryan T, et al. Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density. J Vasc Surg. 2016;64:1101-1111.e2 pubmed publisher
    ..muscle injury, as evidenced by increased inflammation and myofiber atrophy, despite having no differences in CD31(+) and SMA(+) vascular density and area...
  54. Higashi K, Ueda Y, Shimasaki M, Ishigaki Y, Nakamura Y, Oguchi M, et al. High FDG uptake on PET is associated with negative cell-to-cell adhesion molecule E-cadherin expression in lung adenocarcinoma. Ann Nucl Med. 2017;: pubmed publisher
    ..These findings may cause the association between high FDG uptake and negative E-cadherin expression. ..
  55. Hussein A, Saad K, Askar E, Zahran A, Farghaly H, Metwalley K, et al. Functional variants in intercellular adhesion molecule-1 and toll-like receptor-4 genes are more frequent in children with febrile urinary tract infection with renal parenchymal involvement. Acta Paediatr. 2017;: pubmed publisher
  56. Solimando A, Brandl A, Mattenheimer K, Graf C, Ritz M, Ruckdeschel A, et al. JAM-A as a prognostic factor and new therapeutic target in multiple myeloma. Leukemia. 2018;32:736-743 pubmed publisher
    ..These results demonstrate that therapeutic targeting of JAM-A has the potential to prevent MM progression, and lead us to propose JAM-A as a biomarker in MM, and sJAM-A as a serum-based marker for clinical stratification. ..
  57. Alese M, Adewole S, Akinwunmi K, Omonisi A, Alese O. Aspirin-Induced Gastric Lesions Alters EGFR and PECAM-1 Immunoreactivity in Wistar Rats: Modulatory Action of Flavonoid Fraction of Musa Paradisiaca. Open Access Maced J Med Sci. 2017;5:569-577 pubmed publisher
    In this study, Epithelial Growth Factor Receptor and Platelet Endothelial Cell Adhesion Molecule-1 were localised to investigate the healing effects of a flavonoid-rich fraction of M...
  58. Fornasa G, Groyer E, Clement M, Dimitrov J, Compain C, Gaston A, et al. TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol. 2010;184:5485-92 pubmed publisher
    b>CD31 is a transmembrane molecule endowed with T cell regulatory functions owing to the presence of 2 immunotyrosine-based inhibitory motifs...
  59. Barak O, Mladinov S, Hoiland R, Tremblay J, Thom S, Yang M, et al. Disturbed blood flow worsens endothelial dysfunction in moderate-severe chronic obstructive pulmonary disease. Sci Rep. 2017;7:16929 pubmed publisher
    ..05). Oscillatory shear stress elevated circulating markers of endothelial cell apoptosis (CD31+/CD41b- microparticles) in COPD patients, but not age-matched controls...
  60. Wei Y, Lan Y, Liu Y, Meng L, Xu Q, Xie H. Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with ischemic stroke. DNA Cell Biol. 2009;28:151-8 pubmed publisher
    ..The Leu125Val polymorphism of PECAM-1 and its sPECAM-1 levels are associated with ischemic stroke in Chinese population. Our data suggest that the PECAM-1 gene may play a role in the development of ischemic stroke. ..
  61. Xu H, Xu J, Zhang S, Zhu Q, Jin B, ZhuGe D, et al. Temperature-sensitive heparin-modified poloxamer hydrogel with affinity to KGF facilitate the morphologic and functional recovery of the injured rat uterus. Drug Deliv. 2017;24:867-881 pubmed publisher
    ..epithelial cells and luminal epithelial cells but also angiogenesis of injured uterus were observed by Ki67 and CD31 staining after 7?d of treatment with KGF-HP hydrogel...
  62. Asashima T, Iizasa H, Terasaki T, Hosoya K, Tetsuka K, Ueda M, et al. Newly developed rat brain pericyte cell line, TR-PCT1, responds to transforming growth factor-beta1 and beta-glycerophosphate. Eur J Cell Biol. 2002;81:145-52 pubmed
    ..We believe that TR-PCT1 will help us gain a better understanding of the physiological and/or pathophysiological role of pericytes...
  63. Bravo K, Ortega F, Messina G, Sanz M, Fernández Baldo M, Raba J. Integrated bio-affinity nano-platform into a microfluidic immunosensor based on monoclonal bispecific trifunctional antibodies for the electrochemical determination of epithelial cancer biomarker. Clin Chim Acta. 2017;464:64-71 pubmed publisher
    ..This microfluidic immunosensor is intended for use in diagnosis and prognosis of epithelial cancer, to monitor the disease, and to assess therapeutic efficacy. ..
  64. Doñate C, Vijaya Kumar A, Imhof B, Matthes T. Anti-JAM-C therapy eliminates tumor engraftment in a xenograft model of mantle cell lymphoma. J Leukoc Biol. 2016;100:843-853 pubmed
    ..Targeting JAM-C could constitute a new therapeutic strategy reducing lymphoma B-cell proliferation and their capacity to reach supportive lymphoid microenvironments. ..
  65. Forlow S, Ley K. Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1. Am J Physiol Heart Circ Physiol. 2001;280:H634-41 pubmed
    ..Comparison of our data with mice lacking individual or other combinations of adhesion molecules reveal that elimination of more adhesion molecules further reduces leukocyte recruitment but the effect is less than additive...
  66. Todd M. Inflammation and Cognition in Older Adults: Evidence from Taiwan. Biodemography Soc Biol. 2017;63:309-323 pubmed publisher
    ..The observed cross-sectional relationship could reflect a causal relationship that arises earlier in life, or confounding; additional research across the life course is warranted...
  67. Białas M, Papla B, Bulanda A. Immunohistochemical investigation of selected endothelial markers in pulmonary epithelioid haemangioendothelioma. Pol J Pathol. 2011;62:236-40 pubmed
    ..Medications inhibiting vascular endothelial growth factors can be considered as a treatment option for multifocal EH that does not qualify for surgical intervention. ..
  68. Qin D, Yan Y, Hu B, Zhang W, Li H, Li X, et al. Wisp2 disruption represses Cxcr4 expression and inhibits BMSCs homing to injured liver. Oncotarget. 2017;8:98823-98836 pubmed publisher
    ..By tracing the GFP marker, more BMSCs were observed to differentiate into CD31 positive endothelial cells in the functional Wisp2 cells but less in the Wisp2 gene disrupted cells...
  69. Kovacs D, Bastonini E, Ottaviani M, Cota C, Migliano E, Dell Anna M, et al. Vitiligo Skin: Exploring the Dermal Compartment. J Invest Dermatol. 2018;138:394-404 pubmed publisher
  70. Koh Y, Han J, Yoon D, Suh C, Huh J. PD-L1 expression correlates with VEGF and microvessel density in patients with uniformly treated classical Hodgkin lymphoma. Ann Hematol. 2017;96:1883-1890 pubmed publisher
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