PEBP1

Summary

Gene Symbol: PEBP1
Description: phosphatidylethanolamine binding protein 1
Alias: HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, PBP, PEBP, PEBP-1, RKIP, phosphatidylethanolamine-binding protein 1, Raf kinase inhibitory protein, epididymis luminal protein 210, epididymis secretory protein Li 34, epididymis secretory protein Li 96, hippocampal cholinergic neurostimulating peptide, neuropolypeptide h3, prostatic binding protein, raf kinase inhibitor protein
Species: human
Products:     PEBP1

Top Publications

  1. Shemon A, Eves E, Clark M, Heil G, Granovsky A, Zeng L, et al. Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS ONE. 2009;4:e6028 pubmed publisher
    b>Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway...
  2. Zaravinos A, Kanellou P, Baritaki S, Bonavida B, Spandidos D. BRAF and RKIP are significantly decreased in cutaneous squamous cell carcinoma. Cell Cycle. 2009;8:1402-8 pubmed
    ..However, little is known about the implication of BRAF and RKIP expression, or about the incidence of BRAF mutations in the formation of these cutaneous diseases...
  3. Schuierer M, Heilmeier U, Boettcher A, Ugocsai P, Bosserhoff A, Schmitz G, et al. Induction of Raf kinase inhibitor protein contributes to macrophage differentiation. Biochem Biophys Res Commun. 2006;342:1083-7 pubmed
    Differential gene expression analysis of human blood monocytes has identified the Raf kinase inhibitor protein (RKIP) as a continuously upregulated gene in macrophage and dendritic cell maturation...
  4. Karamitopoulou E, Zlobec I, Panayiotides I, Patsouris E, Peros G, Rallis G, et al. Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. Hum Pathol. 2011;42:1888-96 pubmed publisher
    ..regulated kinase [pERK], receptor for hyalouronic acid mediated motility [RHAMM], Raf-1 kinase inhibitor protein [RKIP], ?-catenin, E-cadherin, phosphorylated AK transforming [pAKT], p16, p21, Ki-67, B-cell Lymphoma-2 [BCL2], vascular ..
  5. Yeung K, Janosch P, McFerran B, Rose D, Mischak H, Sedivy J, et al. Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol. 2000;20:3079-85 pubmed
    We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway...
  6. Al Mulla F, Bitar M, Taqi Z, Yeung K. RKIP: much more than Raf kinase inhibitory protein. J Cell Physiol. 2013;228:1688-702 pubmed publisher
    ..protein in bovine brain to its designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical molecule for maintaining subdued, well-orchestrated cellular responses to stimuli...
  7. Kim H, Kim G, Lim S, Kim Y. Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma. Pathology. 2010;42:655-60 pubmed publisher
    Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human cancers...
  8. Tang H, Park S, Sun S, Trumbly R, Ren G, Tsung E, et al. RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. FEBS Lett. 2010;584:662-8 pubmed publisher
    b>RKIP was first identified as an inhibitor of the Raf-MEK-ERK signaling pathway. RKIP was also found to play an important role in the NF-kappaB pathway...
  9. Al Mulla F, Hagan S, Al Ali W, Jacob S, Behbehani A, Bitar M, et al. Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability. J Clin Pathol. 2008;61:524-9 pubmed publisher
    b>Raf kinase inhibitory protein (RKIP; also known as PEBP, for phosphatidylethanolamine-binding protein) is an endogenous inhibitor of the Raf- MAPK kinase (MEK)-MAP kinase pathway...

More Information

Publications62

  1. Eves E, Shapiro P, Naik K, Klein U, Trakul N, Rosner M. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell. 2006;23:561-74 pubmed
    b>Raf kinase inhibitory protein (RKIP or PEBP) is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and a suppressor of cancer metastasis...
  2. Baritaki S, Katsman A, Chatterjee D, Yeung K, Spandidos D, Bonavida B. Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation. J Immunol. 2007;179:5441-53 pubmed
    Raf-1 kinase inhibitor protein (RKIP) has been implicated in the regulation of cell survival pathways and metastases, and is poorly expressed in tumors...
  3. Schuierer M, Bataille F, Weiss T, Hellerbrand C, Bosserhoff A. Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma. Oncol Rep. 2006;16:451-6 pubmed
    ..We analyzed expression of Raf-1 kinase inhibitory protein (RKIP) in HCC...
  4. Corbit K, Trakul N, Eves E, Diaz B, Marshall M, Rosner M. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem. 2003;278:13061-8 pubmed
    ..Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1...
  5. Gimenez M, Souza V, Izumi C, Barbieri M, Chammas R, Oba Shinjo S, et al. Proteomic analysis of low- to high-grade astrocytomas reveals an alteration of the expression level of raf kinase inhibitor protein and nucleophosmin. Proteomics. 2010;10:2812-21 pubmed publisher
    ..05), whereas four proteins were down-regulated, among them raf kinase inhibitor protein (RKIP) (p<0.05)...
  6. Banfield M, Barker J, Perry A, Brady R. Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction. Structure. 1998;6:1245-54 pubmed
    Proteins belonging to the phosphatidylethanolamine-binding protein (PEBP) family are highly conserved throughout nature and have no significant sequence homology with other proteins of known structure or function...
  7. Li H, Wang Y, Gao Y, Shao J, Zhao X, Deng W, et al. Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer. Mol Cancer Res. 2008;6:917-28 pubmed publisher
    ..Studies in cell culture and animal models have suggested a role of Raf kinase inhibitor protein (RKIP) in suppressing the metastatic spread of prostate cancer, breast cancer, and melanoma cells...
  8. Wang J, Yang Y, Wang A, Yao B, Xie G, Feng G, et al. Immunohistochemical detection of the Raf kinase inhibitor protein in nonneoplastic gastric tissue and gastric cancer tissue. Med Oncol. 2010;27:219-23 pubmed publisher
    Expression of the Raf kinase inhibitor protein (RKIP), a metastasis suppressor, is high in normal tissues, low in primary cancers, and lowest or absent in metastatic cancers...
  9. Zlobec I, Baker K, Minoo P, Jass J, Terracciano L, Lugli A. Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression. Clin Cancer Res. 2008;14:143-8 pubmed publisher
    ..015), overexpression of RHAMM (P = 0.008), negative expression of Raf-1 kinase inhibitor protein (RKIP; P = 0.001), and absence of intraepithelial lymphocytes (P = 0...
  10. Yun J, Frankenberger C, Kuo W, Boelens M, Eves E, Cheng N, et al. Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer. EMBO J. 2011;30:4500-14 pubmed publisher
    ..We previously showed that the suppressor Raf kinase inhibitory protein (RKIP) inhibits breast tumour metastasis in part via let-7...
  11. Lorenz K, Lohse M, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature. 2003;426:574-9 pubmed
    ..In our search for a control mechanism for this vital kinase, here we show that the Raf kinase inhibitor protein (RKIP) is a physiological inhibitor of GRK-2...
  12. Fujimori Y, Inokuchi M, Takagi Y, Kato K, Kojima K, Sugihara K. Prognostic value of RKIP and p-ERK in gastric cancer. J Exp Clin Cancer Res. 2012;31:30 pubmed publisher
    ..kinase (ERK), mitogen-activated protein kinase (MEK), an upstream regulator of ERK, and Raf kinase inhibitor protein (RKIP), and investigated correlations of these expressions with clinicopathological features and ..
  13. Dangi Garimella S, Yun J, Eves E, Newman M, Erkeland S, Hammond S, et al. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009;28:347-58 pubmed publisher
    b>Raf kinase inhibitory protein (RKIP) negatively regulates the MAP kinase (MAPK), G protein-coupled receptor kinase-2, and NF-kappaB signalling cascades...
  14. Yeung K, Rose D, Dhillon A, Yaros D, Gustafsson M, Chatterjee D, et al. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol. 2001;21:7207-17 pubmed
    The Raf kinase inhibitor protein (RKIP) acts as a negative regulator of the mitogen-activated protein (MAP) kinase (MAPK) cascade initiated by Raf-1...
  15. Hu C, Zhou L, Zhang J, Huang C, Zhang G. Immunohistochemical detection of Raf kinase inhibitor protein in normal cervical tissue and cervical cancer tissue. J Int Med Res. 2011;39:229-37 pubmed
    b>Raf kinase inhibitor protein (RKIP) may be a suppressor of metastasis: RKIP levels are high in normal tissues, low in primary cancers and lowest or absent in metastatic cancers...
  16. Rath O, Park S, Tang H, Banfield M, Brady R, Lee Y, et al. The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. Cell Signal. 2008;20:935-41 pubmed publisher
    ..The Raf kinase inhibitory protein (RKIP) is a widely expressed negative modulator of the Raf-MEK-ERK signaling pathway...
  17. Hagan S, Al Mulla F, Mallon E, Oien K, Ferrier R, Gusterson B, et al. Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res. 2005;11:7392-7 pubmed
    Raf-1 kinase inhibitor protein (RKIP) was originally identified as the first physiologic inhibitor of the Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) pathway...
  18. Song S, Zhang S, Li Z, Zhou Y, Li B, Bian Z, et al. Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer. Clin Transl Oncol. 2012;14:848-52 pubmed publisher
    b>Raf kinase inhibitory protein (RKIP) is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and a suppressor of cancer metastasis. But its function in pancreatic cancer was not yet clarified completely...
  19. Al Mulla F, Hagan S, Behbehani A, Bitar M, George S, Going J, et al. Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. J Clin Oncol. 2006;24:5672-9 pubmed
    b>Raf kinase inhibitor protein (RKIP) inhibits the Raf and nuclear factor kappa B signaling pathways, and suppresses metastasis in animal models...
  20. Al Mulla F, Bitar M, Al Maghrebi M, Behbehani A, Al Ali W, Rath O, et al. Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3?. Cancer Res. 2011;71:1334-43 pubmed publisher
    b>Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor ?B signaling that represses tumor invasion and metastasis...
  21. Zhang X, Gu H, Yan L, Zhang G. RKIP inhibits the malignant phenotypes of gastric cancer cells. Neoplasma. 2013;60:196-202 pubmed
    b>Raf kinase inhibitor protein (RKIP) is first identified as an interacting partner of Raf-1. RKIP expression is low or absent in several established cell lines derived from metastatic breast cancer, prostate cancer and melanoma cells...
  22. Koelzer V, Karamitopoulou E, Dawson H, Kondi Pafiti A, Zlobec I, Lugli A. Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer. Br J Cancer. 2013;108:2088-96 pubmed publisher
    This study evaluates the geographic expression pattern of Raf-1 Kinase Inhibitor Protein (RKIP) in colorectal cancer (CRC) in correlation with clinicopathological and molecular features, markers of epithelial-mesenchymal transition (EMT) ..
  23. Seddiqi N, Bollengier F, Alliel P, Perin J, Bonnet F, Bucquoy S, et al. Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues. J Mol Evol. 1994;39:655-60 pubmed
    The amino acid sequence of neuropolypeptide h3 from Homo sapiens brain has been determined...
  24. Chen Y, Ouyang G, Yi H, Li M, Zhang P, Li C, et al. Identification of RKIP as an invasion suppressor protein in nasopharyngeal carcinoma by proteomic analysis. J Proteome Res. 2008;7:5254-62 pubmed publisher
    ..b>Raf kinase inhibitor protein (RKIP), one of the downregulated proteins in NPC compared to ANNET, was investigated for its role in ..
  25. Das S, Bhutia S, Sokhi U, Azab B, Su Z, Boukerche H, et al. Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma. Cancer Res. 2012;72:6217-26 pubmed publisher
    ..In contrast, the Raf kinase inhibitor, RKIP, a negative modulator of RAF-stimulated MEKK activation, is strongly downregulated in metastatic melanoma cells...
  26. Ruan L, Wang G, Yi H, Chen Y, Tang C, Zhang P, et al. Raf kinase inhibitor protein correlates with sensitivity of nasopharyngeal carcinoma to radiotherapy. J Cell Biochem. 2010;110:975-81 pubmed publisher
    b>Raf kinase inhibitory protein (RKIP) is a metastasis suppressor whose expression is reduced in nasopharyngeal carcinoma (NPC) tissues and is absent in NPC metastases...
  27. Lee H, Tian B, Sedivy J, Wands J, Kim M. Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology. 2006;131:1208-17 pubmed
    The Raf kinase inhibitor protein (RKIP) has been identified as a suppressor of the mitogen-activated protein kinase (MAPK) pathway. Loss of RKIP function promotes tumor metastasis in prostate cancer and melanoma...
  28. Martinho O, Gouveia A, Silva P, Pimenta A, Reis R, Lopes J. Loss of RKIP expression is associated with poor survival in GISTs. Virchows Arch. 2009;455:277-84 pubmed publisher
    ..However, additional studies screening for new molecular prognostic markers in GISTs are missing. Raf kinase inhibitor protein (RKIP) has been considered as a suppressor of metastasis and a prognostic marker in several neoplasms...
  29. Martinho O, Pinto F, Granja S, Miranda Gonçalves V, Moreira M, Ribeiro L, et al. RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy. PLoS ONE. 2013;8:e59104 pubmed publisher
    ..The raf kinase inhibitory protein (RKIP) has been associated with tumor progression and metastasis in several human neoplasms, however ..
  30. Escara Wilke J, Yeung K, Keller E. Raf kinase inhibitor protein (RKIP) in cancer. Cancer Metastasis Rev. 2012;31:615-20 pubmed publisher
    b>Raf kinase inhibitory protein (RKIP) was initially identified as phosphatidylethanolamine binding protein in bovine brain. It was later identified as a protein that inhibits Raf kinase activation of MEK...
  31. Ren G, Baritaki S, Marathe H, Feng J, Park S, Beach S, et al. Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer. Cancer Res. 2012;72:3091-104 pubmed publisher
    ..Expression levels of the novel tumor and metastasis suppressor Raf-1 kinase inhibitor protein (RKIP) have been shown to correlate negatively with those of EZH2 in breast and prostate cell lines as well as in ..
  32. Shemon A, Heil G, Granovsky A, Clark M, McElheny D, Chimon A, et al. Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. PLoS ONE. 2010;5:e10479 pubmed publisher
    b>Raf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway...
  33. Maki M, Matsukawa N, Yuasa H, Otsuka Y, Yamamoto T, Akatsu H, et al. Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease. J Neuropathol Exp Neurol. 2002;61:176-85 pubmed
    b>Hippocampal cholinergic neurostimulating peptide (HCNP) is involved in the phenotype development of the septo-hippocampal system...
  34. Moon A, Park J, Sung J, Park Y, Kim Y. Reduced expression of Raf-1 kinase inhibitory protein in renal cell carcinoma: a significant prognostic marker. Pathology. 2012;44:534-9 pubmed
    Renal cell carcinoma (RCC) is the third most common urological malignancy. Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor and useful prognostic marker for a variety of human cancers...
  35. Chen Y, Tang C, Ouyang G, Ruan L, Li M, Zhang P, et al. Identification of RKIP as a differentially tyrosine-phosphorylated protein in nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissues by phosphoproteomic approach. Med Oncol. 2009;26:463-70 pubmed publisher
    ..sites of the identified proteins, and Western blotting was used to detect the tyrosine-phosphorylated levels of RKIP in NPC and NNET...
  36. Hellmann J, Rommelspacher H, Muhlbauer E, Wernicke C. Raf kinase inhibitor protein enhances neuronal differentiation in human SH-SY5Y cells. Dev Neurosci. 2010;32:33-46 pubmed publisher
    ..To study the effects of Raf kinase inhibitor protein (RKIP) on neuronal differentiation, we generated neuroblastoma cell lines overexpressing RKIP (RKIP(+)) ..
  37. Martinho O, Granja S, Jaraquemada T, Caeiro C, Miranda Gonçalves V, Honavar M, et al. Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas. PLoS ONE. 2012;7:e30769 pubmed publisher
    ..The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated ..
  38. Odabaei G, Chatterjee D, Jazirehi A, Goodglick L, Yeung K, Bonavida B. Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis. Adv Cancer Res. 2004;91:169-200 pubmed
    ..A novel protein designated Raf-1 kinase inhibitor protein (RKIP) has been partially characterized. RKIP is a member of the phosphatidylethanolamine-binding protein family...
  39. Al Mulla F, Bitar M, Feng J, Park S, Yeung K. A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. PLoS ONE. 2012;7:e29532 pubmed publisher
    Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of sensitizing cancerous cells to radio- and chemotherapy...
  40. Birner P, Jesch B, Schultheis A, Schoppmann S. RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases. Clin Exp Metastasis. 2012;29:551-9 pubmed publisher
    b>Raf kinase inhibitor protein (RKIP) is an inhibitor of Raf-mediated activation of mitogen-activated protein (MAP) kinase (MEK)-MAP kinase and is considered as an important tumor suppressor...
  41. Granovsky A, Clark M, McElheny D, Heil G, Hong J, Liu X, et al. Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism. Mol Cell Biol. 2009;29:1306-20 pubmed publisher
    b>Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) ..
  42. Chatterjee D, Bai Y, Wang Z, Beach S, Mott S, Roy R, et al. RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem. 2004;279:17515-23 pubmed
    ..Here we show that low RKIP expression levels in tumorigenic human prostate and breast cancer cells are rapidly induced upon chemotherapeutic ..
  43. Doyle B, Hagan S, Al Mulla F, Scott L, Harden S, Paul J, et al. Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients. Histopathology. 2013;62:505-10 pubmed
    ..New markers, identifying high-risk Dukes' B patients, are needed. Here, we examine the utility of Raf kinase inhibitor protein (RKIP) as such a marker and promoter methylation as a mechanism of RKIP down-regulation...
  44. Maresch J, Birner P, Zakharinov M, Toumangelova Uzeir K, Natchev S, Guentchev M. Additive effect on survival of Raf kinase inhibitor protein and signal transducer and activator of transcription 3 in high-grade glioma. Cancer. 2011;117:2499-504 pubmed publisher
    ..However, this joint action has not yet been confirmed in human studies. The expression of Raf kinase inhibitory protein (RKIP) was examined in 159 patients with high-grade and low-grade gliomas and correlated with ..
  45. Huerta Yepez S, Yoon N, Hernández Cueto A, Mah V, Rivera Pazos C, Chatterjee D, et al. Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival. BMC Cancer. 2011;11:259 pubmed publisher
    Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways...
  46. Al Mulla F, Bitar M, Taqi Z, Rath O, Kolch W. RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility. Mol Biosyst. 2011;7:928-41 pubmed publisher
    b>RKIP-1 is a metastasis suppressor that is frequently downregulated in aggressive cancers. However, the consequences of RKIP loss in primary or immortalized cells have not yet been explored...
  47. Schoentgen F, Jolles P. From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site. FEBS Lett. 1995;369:22-6 pubmed
    ..These results imply that 21-23 kDa proteins function in oxidoreduction reactions and signal mechanisms during cell growth and maturation. ..
  48. Park S, Rath O, Beach S, Xiang X, Kelly S, Luo Z, et al. Regulation of RKIP binding to the N-region of the Raf-1 kinase. FEBS Lett. 2006;580:6405-12 pubmed
    The Raf kinase inhibitory protein (RKIP) binds to Raf-1 interfering with binding of the MEK substrate and potentially also Raf-1 activation. In response to mitogen stimulation RKIP dissociates from Raf-1 and later re-associates...
  49. Beach S, Tang H, Park S, Dhillon A, Keller E, Kolch W, et al. Snail is a repressor of RKIP transcription in metastatic prostate cancer cells. Oncogene. 2008;27:2243-8 pubmed
    Diminished expression of the metastasis suppressor protein RKIP was previously reported in a number of cancers. The underlying mechanism remains unknown...
  50. Chatterjee D, Sabo E, Tavares R, Resnick M. Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome. Clin Cancer Res. 2008;14:2994-3001 pubmed publisher
    b>Raf Kinase Inhibitory Protein (RKIP) plays a pivotal role in cancer by regulating apoptosis induced by chemotherapeutic agents, or immune-mediated stimuli and is a metastasis suppressor protein...
  51. Park S, Yeung M, Beach S, Shields J, Yeung K. RKIP downregulates B-Raf kinase activity in melanoma cancer cells. Oncogene. 2005;24:3535-40 pubmed
    ..We have previously identified Raf kinase inhibitor protein (RKIP) as a negative regulator of the Raf-MEK-ERK signaling pathway by specifically binding to the Raf-..
  52. Xu Y, Yi Y, Qiu S, Gao Q, Li Y, Dai C, et al. PEBP1 downregulation is associated to poor prognosis in HCC related to hepatitis B infection. J Hepatol. 2010;53:872-9 pubmed publisher
    Phosphatidylethanolamine-binding protein 1 (PEBP1, also RKIP) plays a pivotal role in cancer by regulating multiple cellular signaling processes and suppressing metastasis in animal models...
  53. Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, et al. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 1999;401:173-7 pubmed
    ..This protein inhibits the phosphorylation and activation of MEK by Raf-1 and is designated RKIP (Raf kinase inhibitor protein). In vitro, RKIP binds to Raf-1, MEK and ERK, but not to Ras...