PEAK1

Summary

Gene Symbol: PEAK1
Description: pseudopodium-enriched atypical kinase 1
Alias: SGK269, NKF3 kinase family member, sugen kinase 269, tyrosine-protein kinase SgK269
Species: human

Top Publications

  1. pmc KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer
    Jonathan A Kelber
    Department of Pathology, Division of Surgical Oncology, UCSD, La Jolla, CA 92093, USA
    Cancer Res 72:2554-64. 2012
  2. pmc Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover
    Jeanne M Bristow
    Department of Pathology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:123-31. 2013
  3. doi Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway
    David R Croucher
    Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Cancer Res 73:1969-80. 2013
  4. doi Temporal regulation of EGF signalling networks by the scaffold protein Shc1
    Yong Zheng
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Nature 499:166-71. 2013
  5. ncbi Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
    Osamu Ohara
    Department of Human Gene Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:47-57. 2002
  6. ncbi The protein kinase complement of the human genome
    G Manning
    SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Science 298:1912-34. 2002
  7. pmc The mouse kinome: discovery and comparative genomics of all mouse protein kinases
    Sean Caenepeel
    SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA
    Proc Natl Acad Sci U S A 101:11707-12. 2004
  8. pmc Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]
    Yingchun Wang
    Department of Pathology, Moores Cancer Center, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:10920-5. 2010

Scientific Experts

  • O Ohara
  • David R Croucher
  • Jeanne M Bristow
  • Richard L Klemke
  • Jonathan A Kelber
  • Yingchun Wang
  • Roger J Daly
  • Yong Zheng
  • Robert M Hoffman
  • Michael Bouvet
  • Sharmeela Kaushal
  • Sean Caenepeel
  • G Manning
  • James W Dennis
  • Theresa A Reno
  • Brigid C Browne
  • Darren N Saunders
  • Karen Colwill
  • Stephen A Tate
  • Mohamed A Soliman
  • Luxi Zhang
  • Nicole St-Denis
  • Adrian Pasculescu
  • Anna Yue Dai
  • Carole M Tactacan
  • Steven L Gonias
  • Minji Jo
  • Tony Pawson
  • W Rod Hardy
  • Falko Hochgräfe
  • Anne Claude Gingras
  • Ruth J Lyons
  • Ling Liu
  • David Gallego-Ortega
  • Lorne Taylor
  • Howard Chan
  • Robert Shearer
  • Cunjie Zhang
  • Danny Rickwood
  • Naveid Ali
  • Alexander Swarbrick
  • Rick Bagshaw
  • Frederick D Park
  • Theresa Reno
  • Evangeline Mose
  • Andrew M Lowy
  • Konstantin Stoletov
  • Jessica M Weems
  • Tracy Wright
  • Cristina Metildi
  • Wei Wang
  • Hop S Tran Cao
  • John R Yates
  • Thomas S Edgington
  • Greg T Cantin
  • Rui Lin
  • Sucha Sudarsanam
  • Glen Charydczak
  • Tony Hunter
  • Gerard Manning
  • R Martinez
  • D B Whyte
  • S Sudarsanam
  • T Hunter

Detail Information

Publications9

  1. pmc KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer
    Jonathan A Kelber
    Department of Pathology, Division of Surgical Oncology, UCSD, La Jolla, CA 92093, USA
    Cancer Res 72:2554-64. 2012
    ..Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN)...
  2. pmc Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover
    Jeanne M Bristow
    Department of Pathology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:123-31. 2013
    Pseudopodium-enriched atypical kinase 1 (PEAK1) is a recently described tyrosine kinase that associates with the actin cytoskeleton and focal adhesion (FA) in migrating cells...
  3. doi Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway
    David R Croucher
    Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Cancer Res 73:1969-80. 2013
    ..In this study, we identified novel Lyn kinase substrates, the most prominent of which was the atypical kinase SgK269 (PEAK1). In breast cancer cells, SgK269 expression associated with the basal phenotype...
  4. doi Temporal regulation of EGF signalling networks by the scaffold protein Shc1
    Yong Zheng
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Nature 499:166-71. 2013
    ..reorganization, trafficking and signal termination that binds Shc1 with delayed kinetics, largely through the SgK269 pseudokinase/adaptor protein...
  5. ncbi Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
    Osamu Ohara
    Department of Human Gene Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:47-57. 2002
    ..Taking all these results together, we here conclude that this new method for the construction of size-fractionated cDNA libraries makes it possible to analyze cDNAs efficiently and comprehensively...
  6. ncbi The protein kinase complement of the human genome
    G Manning
    SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Science 298:1912-34. 2002
    ..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons...
  7. pmc The mouse kinome: discovery and comparative genomics of all mouse protein kinases
    Sean Caenepeel
    SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA
    Proc Natl Acad Sci U S A 101:11707-12. 2004
    ..Chromosomal mapping links 163 kinases to mutant phenotypes and unlocks the use of mouse genetics to determine functions of orthologous human kinases...
  8. pmc Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]
    Yingchun Wang
    Department of Pathology, Moores Cancer Center, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:10920-5. 2010
    ..Here, we report the discovery of a cytoskeleton-associated kinase, pseudopodium-enriched atypical kinase 1 (PEAK1). PEAK1 is a 190-kDa nonreceptor tyrosine kinase that localizes to actin filaments and focal adhesions...