PEAK1

Summary

Gene Symbol: PEAK1
Description: NKF3 kinase family member
Alias: SGK269, pseudopodium enriched atypical kinase, pseudopodium-enriched atypical kinase 1, sugen kinase 269, tyrosine-protein kinase SgK269
Species: human

Top Publications

  1. ncbi Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
    Osamu Ohara
    Department of Human Gene Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:47-57. 2002
  2. ncbi The protein kinase complement of the human genome
    G Manning
    SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Science 298:1912-34. 2002
  3. ncbi The mouse kinome: discovery and comparative genomics of all mouse protein kinases
    Sean Caenepeel
    SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA
    Proc Natl Acad Sci U S A 101:11707-12. 2004
  4. ncbi Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]
    Yingchun Wang
    Department of Pathology, Moores Cancer Center, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:10920-5. 2010

Research Grants

  1. Mechanisms of Lamellipodia Growth and Retraction
    Richard L Klemke; Fiscal Year: 2010

Scientific Experts

  • G Manning
  • O Ohara
  • Richard L Klemke
  • Richard Klemke
  • Yingchun Wang
  • Sean Caenepeel
  • John R Yates
  • Thomas S Edgington
  • Hop S Tran Cao
  • Sharmeela Kaushal
  • Robert M Hoffman
  • Rui Lin
  • Jeanne M Bristow
  • Wei Wang
  • Greg T Cantin
  • Michael Bouvet
  • Jonathan A Kelber
  • Sucha Sudarsanam
  • Glen Charydczak
  • Tony Hunter

Detail Information

Publications5

  1. ncbi Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
    Osamu Ohara
    Department of Human Gene Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:47-57. 2002
    ..Taking all these results together, we here conclude that this new method for the construction of size-fractionated cDNA libraries makes it possible to analyze cDNAs efficiently and comprehensively...
  2. ncbi The protein kinase complement of the human genome
    G Manning
    SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Science 298:1912-34. 2002
    ..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons...
  3. ncbi The mouse kinome: discovery and comparative genomics of all mouse protein kinases
    Sean Caenepeel
    SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA
    Proc Natl Acad Sci U S A 101:11707-12. 2004
    ..Chromosomal mapping links 163 kinases to mutant phenotypes and unlocks the use of mouse genetics to determine functions of orthologous human kinases...
  4. ncbi Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]
    Yingchun Wang
    Department of Pathology, Moores Cancer Center, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:10920-5. 2010
    ..Here, we report the discovery of a cytoskeleton-associated kinase, pseudopodium-enriched atypical kinase 1 (PEAK1). PEAK1 is a 190-kDa nonreceptor tyrosine kinase that localizes to actin filaments and focal adhesions...

Research Grants2

  1. Mechanisms of Lamellipodia Growth and Retraction
    Richard L Klemke; Fiscal Year: 2010
    ..We will also determine whether KIAA2002 contributes to cancer progression by regulating cell invasion and metastasis. ..