PDZK1IP1

Summary

Gene Symbol: PDZK1IP1
Description: PDZK1 interacting protein 1
Alias: DD96, MAP17, SPAP, PDZK1-interacting protein 1, 17 kDa membrane-associated protein, epithelial protein up-regulated in carcinoma, membrane associated protein 17, membrane-associated protein 17
Species: human
Products:     PDZK1IP1

Top Publications

  1. Pribanic S, Gisler S, Bacic D, Madjdpour C, Hernando N, Sorribas V, et al. Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells. Am J Physiol Renal Physiol. 2003;285:F784-91 pubmed
    ..We identified MAP17, a 17-kDa membrane protein that has been described to be associated with various human carcinomas, but it is also ..
  2. Guijarro M, Castro M, Romero L, Moneo V, Carnero A. Large scale genetic screen identifies MAP17 as protein bypassing TNF-induced growth arrest. J Cell Biochem. 2007;101:112-21 pubmed
    ..We identified MAP17, a small 17 kDa nonglycosylated membrane protein that localizes to the plasma membrane and the Golgi apparatus...
  3. Guijarro M, Leal J, Fominaya J, Blanco Aparicio C, Alonso S, Lleonart M, et al. MAP17 overexpression is a common characteristic of carcinomas. Carcinogenesis. 2007;28:1646-52 pubmed
    ..We identified MAP17, a small 17 kDa non-glycosylated membrane protein previously identified, being overexpressed in carcinomas...
  4. Guijarro M, Leal J, Blanco Aparicio C, Alonso S, Fominaya J, Lleonart M, et al. MAP17 enhances the malignant behavior of tumor cells through ROS increase. Carcinogenesis. 2007;28:2096-104 pubmed
    ..We identified MAP17, a small 17 kDa non-glycosylated membrane protein previously identified by differential display being over-..
  5. Guijarro M, Link W, Rosado A, Leal J, Carnero A. MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation. Carcinogenesis. 2007;28:2443-50 pubmed
    b>MAP17 is a non-glycosylated membrane-associated protein that has been shown to be over-expressed in human carcinomas, suggesting a possible role of this protein in tumorigenesis...
  6. Kocher O, Cheresh P, Lee S. Identification and partial characterization of a novel membrane-associated protein (MAP17) up-regulated in human carcinomas and modulating cell replication and tumor growth. Am J Pathol. 1996;149:493-500 pubmed
    ..that the DD96 protein product is a 17-kd membrane-associated protein, which we have therefore redesignated MAP17. In normal tissues, MAP17 is expressed in significant amounts only in the kidney, where it was localized to the ..
  7. Atshaves B, McIntosh A, Martin G, Landrock D, Payne H, Bhuvanendran S, et al. Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice. J Lipid Res. 2009;50:1429-47 pubmed publisher
    ..Taken together, these findings support an important role for SCP-2 in hepatic cholesterol homeostasis...
  8. Binepal G, Wenderska I, Crowley P, Besingi R, Senadheera D, Jeannine Brady L, et al. K+ modulates genetic competence and the stress regulon of Streptococcus mutans. Microbiology. 2017;163:719-730 pubmed publisher
    ..At low K+, the expression of stress response elements gcrR and codY, cell-adhesion-associated genes such as spaP and metabolism-associated genes such as bglP was induced at stationary phase (P<0...
  9. Xu X, Zhang J, Wang H, Li Y, Zhang H, Lin D. [Severe idiopathic pulmonary arterial hypertension in pregnancy: a review of 10 cases]. Zhonghua Fu Chan Ke Za Zhi. 2014;49:419-23 pubmed
    ..The systolic pulmonary artery pressure (sPAP) estimated by transthoracic echocardiography was (95.6 ± 1.3) mmHg (1 mmHg = 0.133 kPa) ...

More Information

Publications99

  1. Di Maro G, Orlandella F, Bencivenga T, Salerno P, Ugolini C, Basolo F, et al. Identification of targets of Twist1 transcription factor in thyroid cancer cells. J Clin Endocrinol Metab. 2014;99:E1617-26 pubmed publisher
    ..Quantitative RT-PCR showed that HS6ST2, COL1A1, F2RL1, LEPREL1, PDZK1, and PDZK1IP1 are overexpressed in thyroid carcinoma samples compared with normal thyroids...
  2. Zou L, Zhang S, Xu X, Xiao F, Zhai Z. [Expression of PAI-2 mRNA in peripheral blood leucocytes and regulation by sGC activator in pulmonary hypertension]. Zhonghua Yi Xue Za Zhi. 2016;96:1247-51 pubmed publisher
    ..mRNA level of PAI-2 was negative correlated with echocardiography-estimated systolic pulmonary arterial pressure (sPAP) (r=-0.744, P=0.034)...
  3. Kulshrestha S, Khan S, Hasan S, Khan M, Misba L, Khan A. Calcium fluoride nanoparticles induced suppression of Streptococcus mutans biofilm: an in vitro and in vivo approach. Appl Microbiol Biotechnol. 2016;100:1901-14 pubmed publisher
    ..The qRT-PCR gene expression analysis showed significant downregulation of various virulence genes (vicR, gtfC, ftf, spaP, comDE) associated with biofilm formation...
  4. Lazzeri C, Bonizzoli M, Cianchi G, Batacchi S, Terenzi P, Cozzolino M, et al. Lactate and Echocardiography Before Veno-Venous Extracorporeal Membrane Oxygenation Support. Heart Lung Circ. 2018;27:99-103 pubmed publisher
    ..002). At echocardiography, non survivors showed higher values of systolic pulmonary artery pressure (sPAP) (p=0...
  5. Li A, Zhai Z, Zhai Y, Xie W, Wan J, Tao X. The value of speckle-tracking echocardiography in identifying right heart dysfunction in patients with chronic thromboembolic pulmonary hypertension. Int J Cardiovasc Imaging. 2018;34:1895-1904 pubmed publisher
    ..188 and P = 0.394, respectively). Pearson correlation analysis showed that GLS has no correlation with sPAP as evaluated by echocardiography in CTEPH patients (r = - 0.079, P = 0...
  6. Nomura R, Otsugu M, Naka S, Teramoto N, Kojima A, Muranaka Y, et al. Contribution of the interaction of Streptococcus mutans serotype k strains with fibrinogen to the pathogenicity of infective endocarditis. Infect Immun. 2014;82:5223-34 pubmed publisher
    ..the 120-kDa cell surface collagen-binding protein Cbm and negative for the 190-kDa protein antigen (PA) known as SpaP, P1, antigen I/II, and other designations...
  7. Zhang J, Liu J, Ling J, Tong Z, Fu Y, Liang M. Inactivation of glutamate racemase (MurI) eliminates virulence in Streptococcus mutans. Microbiol Res. 2016;186-187:1-8 pubmed publisher
    ..0001). The expression levels of the gene coding for surface protein antigen P (spaP) and the acid-tolerance related gene (atpD) were down-regulated by 99% (P<0.0001)...
  8. Doutreleau S, Enache I, Pistea C, Geny B, Charloux A. Pulmonary hemodynamics responses to hypoxia and/or CO2 inhalation during moderate exercise in humans. Pflugers Arch. 2018;470:1035-1045 pubmed publisher
    ..b>sPAP increases from rest in ambient air to exercise ranged as follows: ambient +?110%, CO2 inhalation +?135%, ..
  9. Suzuki K, Izumo M, Yoneyama K, Mizukoshi K, Kamijima R, Kou S, et al. Influence of exercise-induced pulmonary hypertension on exercise capacity in asymptomatic degenerative mitral regurgitation. J Cardiol. 2015;66:246-52 pubmed publisher
    ..for detecting exercise-induced pulmonary hypertension (EIPH) defined by systolic pulmonary arterial pressure (SPAP) ≥60mmHg. The mean peak V˙O2 was 22.6±5.1mL/kg/min (86.7±14...
  10. İlgen U, Yayla M, Duzgun N. Anti-angiotensin II type 1 receptor autoantibodies (AT1R-AAs) in patients with systemic sclerosis: lack of association with disease manifestations. Rheumatol Int. 2017;37:593-598 pubmed publisher
    ..the association of serum levels of AT1R-AA with disease duration, systolic pulmonary artery pressure (sPAP) measurements, and disease manifestations like cutaneous, lung and esophageal involvements, and the presence of ..
  11. Altit G, Bhombal S, Hopper R, Tacy T, Feinstein J. Death or resolution: the "natural history" of pulmonary hypertension in bronchopulmonary dysplasia. J Perinatol. 2019;39:415-425 pubmed publisher
    ..ECHO estimation of pulmonary artery pressure (PAP) was available in 84%. PAP was higher in those who died (sPAP/sBP ratio 1.09 ± 27 vs 0.83 ± 20 %, p = 0.0002)...
  12. Wang R, Zhou S, Wu P, Li M, Ding X, Sun L, et al. Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin. Mol Ther Nucleic Acids. 2018;13:44-54 pubmed publisher
    ..The value of systolic pulmonary artery pressure (SPAP) and the ratio of medial thickening in the monocrotaline (MCT) group were increased, whereas the melatonin ..
  13. Wang H, Liu T, Cai Y, Luo L, Wang M, Yang M, et al. Pulmonary hypertension in polymyositis. Clin Rheumatol. 2015;34:2105-12 pubmed publisher
    ..PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥40 mmHg. PH was identified in ten patients (16.39 %) who had few cardiopulmonary symptoms...
  14. Schwarze Zander C, Pabst S, Hammerstingl C, Ohlig J, Wasmuth J, Boesecke C, et al. Pulmonary hypertension in HIV infection: a prospective echocardiographic study. HIV Med. 2015;16:578-82 pubmed publisher
    ..Patients with systolic pulmonary artery pressure (sPAP) > 30 mmHg were more likely to be female, to have a history of injecting drug use and to ..
  15. Ramjug S, Hussain N, Hurdman J, Billings C, Charalampopoulos A, Elliot C, et al. Idiopathic and Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Hemodynamic, and MRI Characteristics and Outcomes. Chest. 2017;152:92-102 pubmed publisher
    ..The relationship between mean pulmonary arterial pressure (mPAP) and systolic pulmonary arterial pressure (sPAP) in IPAH was identical to that previously reported (mPAP = 0.61 sPAP + 2 mm Hg)...
  16. Mancuso F, Moises V, Almeida D, Poyares D, Storti L, Brito F, et al. Prognostic value of real-time three-dimensional echocardiography compared to two-dimensional echocardiography in patients with systolic heart failure. Int J Cardiovasc Imaging. 2018;34:553-560 pubmed publisher
    ..3%; p?=?0.04), and greater E/e' ratio (19?±?9 vs. 16?±?8; p?=?0.04) and systolic pulmonary artery pressure (SPAP) (50?±?15 vs. 36?±?11 mmHg; p?<?0.01). In multivariate analysis, LVEF (OR 4.6; CI 95% 1.2-17.6; p?<?0...
  17. Adil M, Singh K, Verma P, Khan A. Eugenol-induced suppression of biofilm-forming genes in Streptococcus mutans: An approach to inhibit biofilms. J Glob Antimicrob Resist. 2014;2:286-292 pubmed publisher
    ..eugenol on expression of biofilm- and QS-related genes (gtfB, gtfC, comDE, smu630, vicR, brpA, ftf, relA, gbpB and spaP) were checked by quantitative real-time PCR (qRT-PCR)...
  18. Coutinho G, Garcia A, Correia P, Branco C, Antunes M. Negative impact of atrial fibrillation and pulmonary hypertension after mitral valve surgery in asymptomatic patients with severe mitral regurgitation: a 20-year follow-up. Eur J Cardiothorac Surg. 2015;48:548-55; discussion 555-6 pubmed publisher
    ..There was a significant reduction in the systolic pulmonary artery pressure (SPAP) after surgery, more pronounced in Group A patients; nonetheless, the mean SPAP at late follow-up was higher in ..
  19. Sun L, Cai Z, Pu J, Li J, Shen J, Yang C, et al. 5-Aminosalicylic Acid Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats by Increasing the Expression of Nur77. Inflammation. 2017;40:806-817 pubmed publisher
    ..body mass and weight increment except for groups 5-ASA-150 and 5-ASA-200 and greater overall survival rates; (2) SPAP, DPAP, MPAP, and RVHI in 5-ASA-treated groups, except for MPAP and RVHI in 5-ASA-200 group, were lower than those ..
  20. Wang Y, Tian W, Xiu C, Yan M, Wang S, Mei Y. Urantide improves the structure and function of right ventricle as determined by echocardiography in monocrotaline-induced pulmonary hypertension rat model. Clin Rheumatol. 2019;38:29-35 pubmed publisher
    ..Compared with the MCT group, systolic pulmonary arterial pressure (SPAP) and mean pulmonary arterial pressure (mPAP) were significantly lower in the urantide group (P < 0.05)...
  21. Araujo C, Quintero I, Ovaska K, Herrala A, Hautaniemi S, Vihko P. Transmembrane prostatic acid phosphatase (TMPAP) delays cells in G1 phase of the cell cycle. Prostate. 2016;76:151-62 pubmed publisher
    ..We used stable overexpression of the secreted isoform (SPAP) and TMPAP in LNCaP cells, live cell imaging, microarray and qRT-PCR analyses, and fluid phase uptake of HRP and ..
  22. Najjar S, Steiner J, Najjar A, Bechter K. A clinical approach to new-onset psychosis associated with immune dysregulation: the concept of autoimmune psychosis. J Neuroinflammation. 2018;15:40 pubmed publisher
    ..This is particularly relevant to the diagnosis of seronegative but probable autoimmune psychosis (SPAP) that might masquerade as antipsychotic drug-resistant primary psychotic disorder...
  23. Liu S, Zhu W, Zhi Q, Liu J, Wang Y, Lin H. Analysis of sucrose-induced small RNAs in Streptococcus mutans in the presence of different sucrose concentrations. Appl Microbiol Biotechnol. 2017;101:5739-5748 pubmed publisher
    ..The expression levels of sRNAs and target genes (gtfB, gtfC, and spaP) related to virulence were assessed. In addition, some phenotypic traits were evaluated...
  24. Bane O, Shah S, Cuttica M, Collins J, Selvaraj S, Chatterjee N, et al. A non-invasive assessment of cardiopulmonary hemodynamics with MRI in pulmonary hypertension. Magn Reson Imaging. 2015;33:1224-1235 pubmed publisher
    ..wedge pressure (PCWP), time-averaged intra-pulmonary pressure waveforms and pulmonary artery pressures (systolic (sPAP) and diastolic (dPAP))...
  25. Citro R, Bossone E, Parodi G, Carerj S, Ciampi Q, Provenza G, et al. Clinical profile and in-hospital outcome of Caucasian patients with takotsubo syndrome and right ventricular involvement. Int J Cardiol. 2016;219:455-61 pubmed publisher
    ..score index, E/e' ratio, tricuspid annular plane systolic excursion (TAPSE) and systolic pulmonary artery pressure (sPAP) were associated with adverse in-hospital outcome. At multivariate analysis, CCI (HR: 1.871; 95% CI: 1.202-2...
  26. Fabiani I, Conte L, Pugliese N, Calogero E, Barletta V, Di Stefano R, et al. The integrated value of sST2 and global longitudinal strain in the early stratification of patients with severe aortic valve stenosis: a translational imaging approach. Int J Cardiovasc Imaging. 2017;33:1915-1920 pubmed publisher
    ..58; p?=?0.0007), GLS (r?=?0.61; p?=?0.0002), LAVi (r?=?0.51; p?=?0.003), LVMi (r?=?0.43; p?=?0.01), sPAP (r?=?0.36; p?=?0.04) and SVi (r?=?-0.47; p?<?0.005). No correlation was found between MF and sST2...
  27. Toyama H, Takei Y, Saito K, Ota T, Kurotaki K, Ejima Y, et al. Management of three cardiogenic pulmonary edemas occurring in a patient scheduled for left ventricular assist device implantation: indicators for determining left ventricular assist device pump speed. J Anesth. 2016;30:711-5 pubmed publisher
    ..Additionally, systolic pulmonary artery pressure (sPAP), left atrial diameter (LAD), RV end-diastolic diameter (RVEDD) and estimated RV systolic pressure (esRVP) changed ..
  28. Trombetta A, Pizzorni C, Ruaro B, Paolino S, Sulli A, Smith V, et al. Effects of Longterm Treatment with Bosentan and Iloprost on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion, and Clinical Status in Systemic Sclerosis. J Rheumatol. 2016;43:2033-2041 pubmed
    ..videocapillaroscopy, FBP by laser Doppler flowmetry, DU incidence, DLCO, systolic pulmonary arterial pressure (sPAP), renal arterial resistive index, and other biomarkers. From T2 to T4, laser speckled contrast analysis was added...
  29. Morales Rull J, Bielsa S, Conde Martel A, Aramburu Bodas O, Llácer P, Quesada M, et al. Pleural effusions in acute decompensated heart failure: Prevalence and prognostic implications. Eur J Intern Med. 2018;52:49-53 pubmed publisher
    ..2; 95%CI 1.25-3.77), estimated systolic pulmonary artery pressure (sPAP) >55 mm Hg by echocardiography (OR 2.05; 95%CI 1.12-3.75), and serum prealbumin <15 mg/l (OR 1...
  30. Liu D, Hu K, Liebner E, Weidemann F, Herrmann S, Ertl G, et al. Value of low-dose dobutamine stress echocardiography on defining true severe low gradient aortic stenosis in patients with preserved left ventricular ejection fraction. Int J Cardiovasc Imaging. 2018;34:1877-1887 pubmed publisher
    ..Higher systolic pulmonary artery pressure (SPAP, OR 1.43, P = 0.045) was associated with TS-LGAS in patients with LVEF < 50%...
  31. Gencer E, Dogan V, Ozturk M, Nadir A, Musmul A, Cavusoglu Y. Comparison of the Effects of Levosimendan Dobutamine and Vasodilator Therapy on Ongoing Myocardial Injury in Acute Decompensated Heart Failure. J Cardiovasc Pharmacol Ther. 2016;: pubmed
    ..protein [HsCRP], and others), left ventricular ejection fraction (LVEF), systolic pulmonary artery pressure (sPAP), and 6-minute walk distance (6MWD) were compared before and after treatment...
  32. Kivrak T, Durmus E, Sunbul M, Yildizeli B, Mutlu B. [Effect of pulmonary endarterectomy on six-minute walking test and echocardiography in the early stage]. Turk Kardiyol Dern Ars. 2016;44:300-5 pubmed publisher
    ..in ejection fraction (EF) were not significant, significant reduction in systolic pulmonary artery pressure (sPAP) and tricuspid regurgitation were observed...
  33. Zhang Y, Wang D, Liu Y, Tao D, Jin Y, Jiang H, et al. Surgical Management of Severe Ischaemic Mitral Regurgitation. Heart Lung Circ. 2018;27:517-523 pubmed publisher
    ..There was no significant change in LVEF, but LVEDD, LVESD and systolic pulmonary artery pressure (sPAP) improved significantly, and there was no difference between the groups...
  34. Zhang D, Tian X, Feng R, Guo X, Wang P, Situ Y, et al. Secondary pulmonary alveolar proteinosis: a single-center retrospective study (a case series and literature review). BMC Pulm Med. 2018;18:15 pubmed publisher
    Secondary pulmonary alveolar proteinosis (sPAP) is an extremely rare disease. The clinical features of sPAP patients remain to be summarizeds...
  35. Cho I, Chang H, Lee S, Shim C, Hong G, Chung N. Differential Impact of Net Atrioventricular Compliance on Clinical Outcomes in Patients with Mitral Stenosis According to Cardiac Rhythm. J Am Soc Echocardiogr. 2017;30:552-560 pubmed publisher
    ..Cn on symptom status and clinical outcomes, as well as its contribution toward systolic pulmonary artery pressure (SPAP), differed according to cardiac rhythm. We retrospectively reviewed patients (N = 308) with rheumatic pure MS...
  36. Coady M, El Tarazi A, Santer R, Bissonnette P, Sasseville L, Calado J, et al. MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2. J Am Soc Nephrol. 2017;28:85-93 pubmed publisher
    ..176+1G>A) in the MAP17 coding gene (PDZK1IP1)...
  37. Bal Z, Sezer S, Uyar M, Bal U, Kulah E, Guliyev O, et al. Pulmonary hypertension is closely related to arterial stiffness in renal transplant patients. Transplant Proc. 2015;47:1186-9 pubmed publisher
    ..PH was defined as systolic pulmonary artery pressure (sPAP) ≥ 35 mm Hg...
  38. Reque J, Quiroga B, Ruiz C, Villaverde M, Vega A, Abad S, et al. [Pulmonary hypertension in hemodialysis patients: Prevalence and associated factors]. Med Clin (Barc). 2016;146:143-7 pubmed publisher
    ..PH was defined as a systolic pulmonary artery pressure (SPAP) estimated by Doppler ultrasound above 35mmHg...
  39. Giannoni A, Raglianti V, Mirizzi G, Taddei C, Del Franco A, Iudice G, et al. Influence of central apneas and chemoreflex activation on pulmonary artery pressure in chronic heart failure. Int J Cardiol. 2016;202:200-6 pubmed publisher
    ..Patients with CSR presented with: a) higher systolic pulmonary artery pressure (sPAP: 42.8 standard deviation-SD 10.1 vs 32.3 SD 5.7 mmHg, p<0...
  40. Ferreira R, Spensberger D, Silber Y, Dimond A, Li J, Green A, et al. Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expression. Mol Cell Biol. 2013;33:1254-66 pubmed publisher
    ..The Scl +40 enhancer is situated downstream of Map17, the 3' flanking gene of Scl, and is active in transgenic mice during primitive and definitive erythropoiesis...
  41. Erden S, Demir S, Kanatlı U, Danacı F, Carboğa B. The effect of standard pain assessment on pain and analgesic consumption amount in patients undergoing arthroscopic shoulder surgery. Appl Nurs Res. 2017;33:121-126 pubmed publisher
    ..In this study, we aimed to examine the effect of the Standard Pain Assessment Protocol (SPAP), which we developed based on acute pain guidelines, on pain level, and analgesic consumption...
  42. Chakraborty B, Burne R. Effects of Arginine on Streptococcus mutans Growth, Virulence Gene Expression, and Stress Tolerance. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..The genes encoding virulence factors required for attachment/accumulation (gtfB and spaP), bacteriocins (nlmA, nlmB, nlmD, and cipB), and the sigma factor required for ..
  43. Lima M, Nader C, Franco L, Meira Z, Capanema F, Guimarães R, et al. Pulmonary hypertension evaluation by Doppler echocardiogram in children and adolescents with mouth breathing syndrome. Braz J Otorhinolaryngol. 2017;83:292-298 pubmed publisher
    ..The Systolic Pulmonary Artery Pressure (SPAP) was determined by tricuspid regurgitation and the Mean Pulmonary Artery Pressure (MPAP) was calculated from the ..
  44. Testa L, Latib A, De Marco F, De Carlo M, Fiorina C, Montone R, et al. Persistence of Severe Pulmonary Hypertension After Transcatheter Aortic Valve Replacement: Incidence and Prognostic Impact. Circ Cardiovasc Interv. 2016;9: pubmed publisher
    ..were enrolled in 6 high-volume centers and analyzed as follows: group 1, systolic pulmonary artery pressure (sPAP) <40 mm?Hg (346 patients; 35%); group 2, sPAP 40 to 60 mm?Hg (426 patients; 43%); and group 3, sPAP >60 mm?Hg ..
  45. Baker J. A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors. PLoS ONE. 2010;5:e15487 pubmed publisher
    ..cell lines were constructed with each of the turkey β-adrenoceptors and 3H-CGP12177 whole cell binding, CRE-SPAP production and (3)H-cAMP accumulation assays performed...
  46. Rossi A, Dini F, Agricola E, Faggiano P, Benfari G, Temporelli P, et al. Left atrial dilatation in systolic heart failure: a marker of poor prognosis, not just a buffer between the left ventricle and pulmonary circulation. J Echocardiogr. 2018;16:155-161 pubmed publisher
    The relation between systolic pulmonary pressure (sPAP) and left atrium in patients with heart failure (HF) is unclear...
  47. Denault A, Bussieres J, Arellano R, Finegan B, Gavra P, Haddad F, et al. A multicentre randomized-controlled trial of inhaled milrinone in high-risk cardiac surgical patients. Can J Anaesth. 2016;63:1140-53 pubmed publisher
    ..0 (2.6), and the baseline mean (SD) systolic pulmonary artery pressure (SPAP) was 53 (9) mmHg. The use of iMil was associated with increases in cardiac output (P = 0...
  48. Azari A, Beheshti A, Moravvej Z, Bigdelu L, Salehi M. Surgical embolectomy versus thrombolytic therapy in the management of acute massive pulmonary embolism: Short and long-term prognosis. Heart Lung. 2015;44:335-9 pubmed publisher
    ..Early and late mortality, systolic pulmonary artery pressure (SPAP), right ventricular diameter (RVD) and bleeding complications were evaluated...
  49. Sanati H, Zolfaghari R, Samiei N, Rezaei Y, Chitsazan M, Zahedmehr A, et al. Mitral valve resistance determines hemodynamic consequences of severe rheumatic mitral stenosis and immediate outcomes of percutaneous valvuloplasty. Echocardiography. 2017;34:162-168 pubmed publisher
    ..8±10.5 years. MVR ?140.6 dynes·s/cm5 detected systolic pulmonary arterial pressure (sPAP) >55 mm Hg with a sensitivity of 100% and a specificity of 74%. The sensitivity and specificity of MVA<0...
  50. Galli E, Fournet M, Chabanne C, Lelong B, Leguerrier A, Flecher E, et al. Prognostic value of left atrial reservoir function in patients with severe aortic stenosis: a 2D speckle-tracking echocardiographic study. Eur Heart J Cardiovasc Imaging. 2016;17:533-41 pubmed publisher
    ..regression analysis, LV global longitudinal strain, mitral E/e' ratio, and systolic pulmonary arterial pressure (sPAP) were the best correlates to PLAS. During follow-up, the predefined MACEs occurred in 39 patients...
  51. Hu K, Liu D, Störk S, Herrmann S, Oder D, Ertl G, et al. Echocardiographic Determinants of One-Year All-Cause Mortality in Patients With Chronic Heart Failure Complicated by Significant Functional Tricuspid Regurgitation. J Card Fail. 2017;23:434-443 pubmed publisher
    ..05). Compared to baseline levels, systolic pulmonary artery pressure (sPAP) was significantly reduced in nonsurvivors during follow-up echocardiography (54?±?19 vs 49?±?21?mm?Hg; P?=?...
  52. Kovacs G, Avian A, Wutte N, Hafner F, Moazedi Fürst F, Kielhauser S, et al. Changes in pulmonary exercise haemodynamics in scleroderma: a 4-year prospective study. Eur Respir J. 2017;50: pubmed publisher
    ..The primary end-point was the echocardiographic systolic pulmonary arterial pressure at 50?W exercise (sPAP50).We included 99 patients, of whom 58 had a complete dataset...
  53. Wang T, Lu J, Chen Y, Li Q, Ye Q, Gao J, et al. [The application of peripartum use of pulmonary artery catheter in pregnant patients with pulmonary hypertension]. Zhonghua Nei Ke Za Zhi. 2015;54:773-7 pubmed
    ..The systolic pulmonary artery pressure (sPAP) measured by preoperative echocardiography has no significant difference between the PAC inserted patients [(103...
  54. Baptista R, Serra S, Martins R, Teixeira R, Castro G, Salvador M, et al. Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic review. Arthritis Res Ther. 2016;18:153 pubmed publisher
    ..The elevation of systolic pulmonary arterial pressure (sPAP) during exercise in patients with SSc with normal resting haemodynamics may anticipate the development of PAH...
  55. Gustavsson C, Nordqvist M, Bröms K, Jerdén L, Kallings L, Wallin L. What is required to facilitate implementation of Swedish physical activity on prescription? - interview study with primary healthcare staff and management. BMC Health Serv Res. 2018;18:196 pubmed publisher
    The method, Swedish Physical Activity on Prescription (SPAP), has been launched in Swedish healthcare to promote physical activity for prevention and treatment of lifestyle related health disorders...
  56. De Miguel Luken M, Chaves Conde M, Quintana B, Menoyo A, Tirado I, de Miguel Luken V, et al. Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival. Oncotarget. 2016;7:31723-37 pubmed publisher
    ..to determine whether gH2AX phosphorylation (pH2AX) alone or in combination with the membrane protein MAP17 (PDZK1IP1) could be used as prognostic biomarkers...
  57. Zhang C, Liu Y, Qing E, Ma J. [Preoperative risk factors analysis of pulmonary hypertension crisis during perioperative period for caesarean section of woman with severe pulmonary hypertension]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:431-435 pubmed publisher
    ..fraction (LVEF), left ventricular diastolic final diameter (LVEDD), the pulmonary artery systolic pressure (sPAP) estimated by ultrasonic TI method, radial artery systolic blood pressure (SBP) and diastolic blood pressure (DBP), ..
  58. Zhu W, Li Y, Li H, Lü X, Kong L, Ye X, et al. Integrative Cardiopulmonary Ultrasound for Interstitial Lung Disease Assessment: Correlation between Lung Ultrasound Performance and Cardiac Involvement. Ultrasound Med Biol. 2017;43:744-752 pubmed publisher
    ..between lung ultrasound signs and echocardiographic parameters such as systolic pulmonary artery pressure (SPAP) and various right ventricular parameters...
  59. Silver D, Wang N, Vogel S. Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. J Biol Chem. 2003;278:28528-32 pubmed
    ..an in vivo PDZK1-interacting protein that we named small PDZK1-associated protein (SPAP; also known as DD96/MAP17). Unexpectedly, we found that hepatic overexpression of SPAP in mice resulted in liver deficiency of PDZK1...
  60. Berger M, Macholz F, Lehmann L, Dankl D, Hochreiter M, Bacher B, et al. Remote ischemic preconditioning does not prevent acute mountain sickness after rapid ascent to 3,450 m. J Appl Physiol (1985). 2017;123:1228-1234 pubmed publisher
    ..AMS was evaluated by the Lake Louise score (LLS) and the AMS-C score. Systolic pulmonary artery pressure (SPAP) was assessed by transthoracic Doppler echocardiography...
  61. Sugarbaker D, Richards W, Gordon G, Dong L, De Rienzo A, Maulik G, et al. Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc Natl Acad Sci U S A. 2008;105:3521-6 pubmed publisher
    ..Of the seven point mutations, three were observed in at least one tumor from 49 other MPM patients. The mutations were in genes that could be causally related to cancer and included XRCC6, PDZK1IP1, ACTR1A, and AVEN.
  62. Goublaire C, Melissopoulou M, Lobo D, Kubota N, Verdonk C, Cimadevilla C, et al. Prognostic Value of Exercise-Stress Echocardiography in Asymptomatic Patients With Aortic Valve Stenosis. JACC Cardiovasc Imaging. 2018;11:787-795 pubmed publisher
    ..evaluate the prognostic value of mean pressure gradient (MPG) increase and peak systolic pulmonary artery pressure (SPAP) measured during exercise stress echocardiography in asymptomatic patients with aortic stenosis (AS)...
  63. Noh M, Yeo H, Ko J, Kim H, Lee C. MAP17 is associated with the T-helper cell cytokine-induced down-regulation of filaggrin transcription in human keratinocytes. Exp Dermatol. 2010;19:355-62 pubmed publisher
    ..microarray databases for different skin diseases, we revealed seven commonly up-regulated genes, DSG3, KRT6, MAP17, PLSCR1, RPM2, SOD2 and SPRR2B...
  64. Haeck M, Kapel G, Scherptong R, Swenne C, Maan A, Bax J, et al. Detection of elevated pulmonary pressures by the ECG-derived ventricular gradient: A comparison of conversion matrices in patients with suspected pulmonary hypertension. J Electrocardiol. 2017;50:115-122 pubmed publisher
    ..vectorcardiogram (VCG) and the Kors-derived VCG to detect elevated systolic pulmonary artery pressure (SPAP) in suspected pulmonary hypertension (PH)...
  65. García Heredia J, Lucena Cacace A, Verdugo Sivianes E, Pérez M, Carnero A. The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB. Clin Cancer Res. 2017;23:3871-3883 pubmed publisher
    ..We have used patient-derived xenografts (PDX) and public transcriptomic databases of human tumors.Results: MAP17 (PDZKIP1), a small cargo protein overexpressed in tumors, interacts with NUMB through the PDZ-binding domain ..
  66. Zilkenat S, Franz Wachtel M, Stierhof Y, Galán J, Macek B, Wagner S. Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach. Mol Cell Proteomics. 2016;15:1598-609 pubmed publisher
    ..Here, we provide evidence that the export apparatus of type III secretion systems contains five SpaP, one SpaQ, one SpaR, and one SpaS...
  67. Allemann Y, Sartori C, Lepori M, Pierre S, Melot C, Naeije R, et al. Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude. Am J Physiol Heart Circ Physiol. 2000;279:H2013-6 pubmed
    ..Many studies of HAPE have estimated systolic pulmonary arterial pressure (SPAP) with Doppler echocardiography...
  68. Toyama K, Ayabe K, Kar S, Kubo S, Minamishima T, Rader F, et al. Postprocedural Changes of Tricuspid Regurgitation After MitraClip Therapy for Mitral Regurgitation. Am J Cardiol. 2017;120:857-861 pubmed publisher
    ..The TR regression group showed a significant reduction in the systolic pulmonary artery pressure (sPAP) (49?±?13 to 37?±?11?mm?Hg, p <0...
  69. Muñoz Galván S, Gutierrez G, Perez M, Carnero A. MAP17 (PDZKIP1) Expression Determines Sensitivity to the Proteasomal Inhibitor Bortezomib by Preventing Cytoprotective Autophagy and NFκB Activation in Breast Cancer. Mol Cancer Ther. 2015;14:1454-65 pubmed publisher
    b>MAP17 is a small nonglycosylated membrane protein that is overexpressed in a high percentage of carcinomas...
  70. Li Y, Wang Y, Li H, Zhu W, Meng X, Lu X. Evaluation of the hemodynamics and right ventricular function in pulmonary hypertension by echocardiography compared with right-sided heart catheterization. Exp Ther Med. 2017;14:3616-3622 pubmed publisher
    ..Patients were divided into the following two groups according to their difference between SPAPecho and SPAPRHC measurement: The overestimated group and underestimated group...
  71. Gisler S, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin L, et al. PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int. 2003;64:1733-45 pubmed
    ..screens, the most abundant candidate protein to interact with PDZK1 was the membrane-associated protein of 17 kD (MAP17)...
  72. García Heredia J, Carnero A. The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment. Oncotarget. 2017;8:98580-98597 pubmed publisher
    ..b>MAP17 is a cargo protein that transports membrane proteins from the endoplasmic reticulum...
  73. Coady M, Wallendorff B, Lapointe J. Characterization of the transport activity of SGLT2/MAP17, the renal low-affinity Na+-glucose cotransporter. Am J Physiol Renal Physiol. 2017;313:F467-F474 pubmed publisher
    The cotransporter SGLT2 is responsible for 90% of renal glucose reabsorption, and we recently showed that MAP17 appears to work as a required ?-subunit...
  74. Gottgens B, Barton L, Chapman M, Sinclair A, Knudsen B, Grafham D, et al. Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci. Genome Res. 2002;12:749-59 pubmed
    ..and characterization of the zebrafish SCL locus together with the identification of three neighboring genes, IER5, MAP17, and MUPP1...
  75. Perez M, Peinado Serrano J, García Heredia J, Felipe Abrio I, Tous C, Ferrer I, et al. Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1). Oncotarget. 2016;7:67033-67046 pubmed publisher
    ..Many tumors display marginal levels of chemoresponsiveness, and new treatment approaches are needed. MAP17 is a small non-glycosylated membrane protein overexpressed in carcinomas...
  76. Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown L, et al. PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Lab Invest. 1999;79:1161-70 pubmed
    We recently reported the isolation and partial characterization of two novel proteins, MAP17 and PDZK1. Using in situ hybridization, we demonstrated that MAP17 and PDZK1 mRNAs are markedly up-regulated in human carcinomas...
  77. Zientara A, Genoni M, Graves K, Odavic D, Loblein H, Häussler A, et al. Tricuspid Valve Repair for the Poor Right Ventricle: Tricuspid Valve Repair in Patients with Mild-to-Moderate Tricuspid Regurgitation Undergoing Mitral Valve Repair Improves In-Hospital Outcome. Thorac Cardiovasc Surg. 2017;65:612-616 pubmed publisher
    ..were compared: postoperative and peak dose of noradrenaline (NA), pre/postoperative systolic pulmonary pressure (sPAP), extubation time, operation time, cross-clamp time, cardiopulmonary bypass (CPB) time, pre/postoperative ejection ..
  78. Kocher O, Cheresh P, Brown L, Lee S. Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique. Clin Cancer Res. 1995;1:1209-15 pubmed
    ..up-regulated in renal cell carcinoma compared with normal renal parenchyma, we isolated a novel gene, designated DD96. As determined by in situ and Northern blot hybridization studies, DD96 is expressed only in rare normal epithelial ..
  79. Guo L, Shokeen B, He X, Shi W, Lux R. Streptococcus mutans SpaP binds to RadD of Fusobacterium nucleatum ssp. polymorphum. Mol Oral Microbiol. 2017;32:355-364 pubmed publisher
    ..mutans. Screening of existing mutant derivatives indicated SpaP as the major S. mutans adhesin specific for binding to Fusobacterium nucleatum ssp...
  80. Chen X, Liao Y, Yu Y, Zhu P, Li J, Qin L, et al. Elevation of MAP17 enhances the malignant behavior of cells via the Akt/mTOR pathway in hepatocellular carcinoma. Oncotarget. 2017;8:92589-92603 pubmed publisher
    b>MAP17, a small non-glycosylated membrane protein, was significantly up-regulated in hepatocellular carcinoma (HCC) tissues in our previous genome-wide microarray analysis...
  81. Esberg A, Sheng N, Mårell L, Claesson R, Persson K, Boren T, et al. Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development. EBioMedicine. 2017;24:205-215 pubmed publisher
    ..We therefore investigated if adhesin types of S.mutans with sucrose-independent adhesion to host DMBT1 (i.e. SpaP A, B or C) and collagen (i.e. Cnm, Cbm) match and predict individual differences in caries development...
  82. Blissenbach B, Nakas C, Kronke M, Geiser T, Merz T, Pichler Hefti J. Hypoxia-induced changes in plasma microRNAs correlate with pulmonary artery pressure at high altitude. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00146.2017 pubmed publisher
    ..and -190 were measured by quantitative Real-time (qRT)-PCR and correlated with systolic pulmonary artery pressure (SPAP), which was assessed by echocardiography...
  83. Skaf S, Thibault B, Khairy P, O Meara E, Fortier A, Vakulenko H, et al. Impact of Left Ventricular vs Biventricular Pacing on Reverse Remodelling: Insights From the Evaluation of Resynchronization Therapy for Heart Failure (EARTH) Trial. Can J Cardiol. 2017;33:1274-1282 pubmed publisher
    ..and function, mitral regurgitation (MR), indices of diastolic function, systolic pulmonary artery pressure (sPAP), and disease-specific biomarkers. One hundred twenty patients (60.9 ± 8.8 years; 75.0% men; LVEF, 24.4% ± 6...
  84. Zhuan B, Yu Y, Yang Z, Zhao X, Li P. Mechanisms of oxidative stress effects of the NADPH oxidase-ROS-NF-?B transduction pathway and VPO1 on patients with chronic obstructive pulmonary disease combined with pulmonary hypertension. Eur Rev Med Pharmacol Sci. 2017;21:3459-3464 pubmed
    ..Systolic pulmonary pressure (SPAP) (63.65±9.47 mmHg) of the observation group was higher than SPAP (53.13±7.52 mmHg) of the control group (p<0...
  85. De Miguel Luken M, Chaves Conde M, de Miguel Luken V, Muñoz Galvan S, López Guerra J, Mateos J, et al. MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer. Oncotarget. 2015;6:12625-36 pubmed
    ..b>MAP17 is a small non-glycosylated membrane protein overexpressed in carcinomas...
  86. Guijarro M, Vergel M, Marin J, Muñoz Galvan S, Ferrer I, Ramon Y Cajal S, et al. p38? limits the contribution of MAP17 to cancer progression in breast tumors. Oncogene. 2012;31:4447-59 pubmed publisher
    b>MAP17 is a small, 17-kDa, non-glycosylated membrane protein that is overexpressed in a percentage of carcinomas. In the present work, we have analyzed the role of MAP17 expression during mammary cancer progression...
  87. Kocher O, Comella N, Tognazzi K, Brown L. Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains. Lab Invest. 1998;78:117-25 pubmed
    We recently reported the isolation and partial characterization of a novel membrane-associated protein designated MAP17. In normal tissues, MAP17 was expressed only in the apical brush border of proximal tubular epithelial cells of the ..
  88. Yang G, Zong H. Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic cholangiocarcinoma. Mol Med Rep. 2016;13:4786-90 pubmed publisher
    ..Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the iCCA samples when compared with the matched para?tumor samples...
  89. Carreira P, Carmona L, Joven B, Loza E, Andreu J, Riemekasten G, et al. Clinical determinants of elevated systolic pulmonary artery pressure measured by transthoracic Doppler echocardiography in early systemic sclerosis. Clin Exp Rheumatol. 2017;35 Suppl 106:114-121 pubmed
    To explore the prevalence and clinical associations of elevated systolic pulmonary artery pressure (sPAP), measured by Transthoracic Doppler-echocardiography (TTE) in patients with early systemic sclerosis (SSc)...
  90. Perez M, Praena Fernández J, Felipe Abrio B, Lopez Garcia M, Lucena Cacace A, Garcia A, et al. MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival. PLoS ONE. 2013;8:e56169 pubmed publisher
    b>MAP17 is a membrane-associated protein that is overexpressed in human tumors...