PDI

Summary

Gene Symbol: PDI
Description: protein disulfide isomerase family A member 2
Alias: PDA2, PDI, PDIP, PDIR, protein disulfide-isomerase A2, Rho GDP dissociation inhibitor gamma, pancreas-specific protein disulfide isomerase, pancreatic protein disulfide isomerase, protein disulfide isomerase, pancreatic, protein disulfide isomerase-associated 2
Species: human
Products:     PDI

Top Publications

  1. Swiatkowska M, Padula G, Michalec L, Stasiak M, Skurzynski S, Cierniewski C. Ero1alpha is expressed on blood platelets in association with protein-disulfide isomerase and contributes to redox-controlled remodeling of alphaIIbbeta3. J Biol Chem. 2010;285:29874-83 pubmed publisher
    Recent evidence supports a role of protein-disulfide isomerase (PDI) in redox-controlled remodeling of the exofacial domains of ?(IIb)?(3) in blood platelets...
  2. DeSilva M, Lu J, Donadel G, Modi W, Xie H, Notkins A, et al. Characterization and chromosomal localization of a new protein disulfide isomerase, PDIp, highly expressed in human pancreas. DNA Cell Biol. 1996;15:9-16 pubmed
    ..In this study we describe the isolation and characterization from human pancreas of a new protein, PDIp, that is structurally and functionally related to PDIs...
  3. Markovic I, Stantchev T, Fields K, Tiffany L, Tomic M, Weiss C, et al. Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry. Blood. 2004;103:1586-94 pubmed
    ..Catalysts with redox-isomerase activity, such as protein disulfide isomerase (PDI), facilitate Env conversion from its inactive to its fusion-competent conformation...
  4. Ou W, Silver J. Role of protein disulfide isomerase and other thiol-reactive proteins in HIV-1 envelope protein-mediated fusion. Virology. 2006;350:406-17 pubmed
    Cell-surface protein disulfide isomerase (PDI) has been proposed to promote disulfide bond rearrangements in HIV-1 envelope protein (Env) that accompany Env-mediated fusion...
  5. Fu X, Zhu B. Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells. J Steroid Biochem Mol Biol. 2009;115:20-9 pubmed publisher
    ..Here we report that, of the six representative PDI homologs examined (human PDI, PDIp, ERp57, ERp72, PDIA6 and rat PDIr), only the human pancreas-specific PDI homolog (PDIp) had a similar binding affinity for radiolabeled 17beta-..
  6. Pirneskoski A, Klappa P, Lobell M, Williamson R, Byrne L, Alanen H, et al. Molecular characterization of the principal substrate binding site of the ubiquitous folding catalyst protein disulfide isomerase. J Biol Chem. 2004;279:10374-81 pubmed
    ..endoplasmic reticulum of eukaryotes is catalyzed by the ubiquitously expressed enzyme protein disulfide isomerase (PDI)...
  7. Billington J, Hickling T, Munro G, Halai C, Chung R, Dodson G, et al. Stability of a receptor-binding active human immunodeficiency virus type 1 recombinant gp140 trimer conferred by intermonomer disulfide bonding of the V3 loop: differential effects of protein disulfide isomerase on CD4 and coreceptor binding. J Virol. 2007;81:4604-14 pubmed
    ..Treatment of rgp140 with protein disulfide isomerase (PDI) severely restricted 17b binding capabilities...
  8. Auwerx J, Isacsson O, Söderlund J, Balzarini J, Johansson M, Lundberg M. Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication. Int J Biochem Cell Biol. 2009;41:1269-75 pubmed publisher
    ..Protein disulfide isomerase (PDI) catalyzes the disulfide reduction in vitro and inhibition of this enzyme blocks viral entry...
  9. Li S, Hong X, Shi Y, Li H, Wang C. Annular arrangement and collaborative actions of four domains of protein-disulfide isomerase: a small angle X-ray scattering study in solution. J Biol Chem. 2006;281:6581-8 pubmed
    We presented for the first time a small angle x-ray scattering study of intact protein-disulfide isomerase (PDI) in solution...

More Information

Publications104 found, 100 shown here

  1. Wallis A, Sidhu A, Byrne L, Howard M, Ruddock L, Williamson R, et al. The ligand-binding b' domain of human protein disulphide-isomerase mediates homodimerization. Protein Sci. 2009;18:2569-77 pubmed publisher
    Purified preparations of the recombinant b'x domain fragment of human protein-disulphide isomerase (PDI), which are homogeneous by mass spectrometry and sodium dodecyl sulfate polyacrylamide gel electrophoresis, comprise more than one ..
  2. Nguyen V, Wallis K, Howard M, Haapalainen A, Salo K, Saaranen M, et al. Alternative conformations of the x region of human protein disulphide-isomerase modulate exposure of the substrate binding b' domain. J Mol Biol. 2008;383:1144-55 pubmed publisher
    Protein disulphide isomerase (PDI) is a key multi-domain protein folding catalyst in the endoplasmic reticulum. The b' domain of PDI is essential for the non-covalent binding of incompletely folded protein substrates...
  3. Denisov A, Maattanen P, Dabrowski C, Kozlov G, Thomas D, Gehring K. Solution structure of the bb' domains of human protein disulfide isomerase. FEBS J. 2009;276:1440-9 pubmed publisher
    ..Our findings provide a structural basis for previous kinetic and cross-linking studies which have shown that protein disulfide isomerase exhibits a saturable, substrate-binding site. ..
  4. Papandréou M, Barbouche R, Guieu R, Rivera S, Fantini J, Khrestchatisky M, et al. Mapping of domains on HIV envelope protein mediating association with calnexin and protein-disulfide isomerase. J Biol Chem. 2010;285:13788-96 pubmed publisher
    The cell catalysts calnexin (CNX) and protein-disulfide isomerase (PDI) cooperate in establishing the disulfide bonding of the HIV envelope (Env) glycoprotein...
  5. Reiser K, François K, Schols D, Bergman T, Jornvall H, Balzarini J, et al. Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120. Int J Biochem Cell Biol. 2012;44:556-62 pubmed publisher
    ..Previous studies indicate that protein disulfide isomerase (PDI), thioredoxin-1 (Trx1), and glutaredoxin-1 (Grx1) catalyze gp120 reduction, but their specific disulfide targets ..
  6. Appenzeller Herzog C, Riemer J, Zito E, Chin K, Ron D, Spiess M, et al. Disulphide production by Ero1?-PDI relay is rapid and effectively regulated. EMBO J. 2010;29:3318-29 pubmed publisher
    ..Both the oxidase Ero1? and the oxidoreductase protein disulphide isomerase (PDI) strongly contribute to the rapid recovery kinetics, but experiments in ERO1-deficient cells indicate the existence ..
  7. Khan M, Simizu S, Lai N, Kawatani M, Shimizu T, Osada H. Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120. ACS Chem Biol. 2011;6:245-51 pubmed publisher
    Protein disulfide isomerase (PDI) is a promiscuous protein with multifunctional properties. PDI mediates proper protein folding by oxidation or isomerization and disrupts disulfide bonds by reduction...
  8. Gallina A, Hanley T, Mandel R, Trahey M, Broder C, Viglianti G, et al. Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry. J Biol Chem. 2002;277:50579-88 pubmed
    We previously reported that monoclonal antibodies to protein-disulfide isomerase (PDI) and other membrane-impermeant PDI inhibitors prevented HIV-1 infection...
  9. Barbouche R, Miquelis R, Jones I, Fenouillet E. Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion. J Biol Chem. 2003;278:3131-6 pubmed
    ..Inhibition of lymphocyte surface-associated protein-disulfide isomerase (PDI) blocks HIV/cell fusion, suggesting that redox changes within Env are required...
  10. Fraldi A, Zito E, Annunziata F, Lombardi A, Cozzolino M, Monti M, et al. Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. Hum Mol Genet. 2008;17:2610-21 pubmed publisher
    ..Here we show that SUMF1 interacts with protein disulfide isomerase (PDI) and ERp44, two thioredoxin family members residing in the early secretory pathway, and with ERGIC-53, a lectin ..
  11. Bernardi K, Williams J, Kikkert M, van Voorden S, Wiertz E, Ye Y, et al. The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation. Mol Biol Cell. 2010;21:140-51 pubmed publisher
  12. Wang Z, Zhou Z, Guo Z, Chi C. Snapshot of the interaction between HIV envelope glycoprotein 120 and protein disulfide isomerase. Acta Biochim Biophys Sin (Shanghai). 2010;42:358-62 pubmed
    ..Previous studies suggest the cell surface protein disulfide isomerase (PDI) might interact with disulfide bond(s) of gp120 and thus facilitate HIV-1 entry...
  13. Araki K, Nagata K. Functional in vitro analysis of the ERO1 protein and protein-disulfide isomerase pathway. J Biol Chem. 2011;286:32705-12 pubmed publisher
    ..by efficient electron relays driven by enzymatic reactions centering on the ERO1-protein-disulfide isomerase (PDI) pathway. A controlled in vitro oxygen consumption assay was carried out to analyze the ERO1-PDI reaction...
  14. Otsu M, Bertoli G, Fagioli C, Guerini Rocco E, Nerini Molteni S, Ruffato E, et al. Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44. Antioxid Redox Signal. 2006;8:274-82 pubmed
    ..interchange reactions: Ero1alpha and Ero1beta transfer oxidative equivalents to protein disulfide isomerase (PDI), which in turn oxidizes cargo proteins...
  15. Raturi A, Miersch S, Hudson J, Mutus B. Platelet microparticle-associated protein disulfide isomerase promotes platelet aggregation and inactivates insulin. Biochim Biophys Acta. 2008;1778:2790-6 pubmed publisher
    ..Here we sought to investigate whether, like platelets, protein disulfide isomerase (PDI) is present on the surface of pMP and, if so, to analyze its contribution to platelet hyperaggregability and ..
  16. Wang C, Li W, Ren J, Fang J, Ke H, Gong W, et al. Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase. Antioxid Redox Signal. 2013;19:36-45 pubmed publisher
    ..The redox-regulated open/closed conformational switch of hPDI endows the protein with versatile target-binding capacities for its enzymatic and chaperone functions. ..
  17. Elmasry K, Ibrahim A, Saleh H, Elsherbiny N, Elshafey S, Hussein K, et al. Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy. Diabetologia. 2018;61:1220-1232 pubmed publisher
    ..kinase-like ER-regulated kinase (p-PERK), activating transcription factor 6 (ATF6) and protein disulfide isomerase (PDI) in HRECs...
  18. Machado J, Iborra R, Fusco F, Castilho G, Pinto R, Machado Lima A, et al. N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1. Atherosclerosis. 2014;237:343-52 pubmed publisher
    ..serum albumin (1 mg/mL; 18 h) from all groups, and the expression of ERS markers (protein disulfide isomerase - PDI, Grp78 and Grp94), ABCA-1 and ABCG-1 determined by immunoblot...
  19. Ye Z, Zhang J, Ancrum T, Manevich Y, Townsend D, Tew K. Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response. Antioxid Redox Signal. 2017;26:247-261 pubmed publisher
    ..in the regulation of ER stress (immunoglobulin heavy chain-binding protein [BiP], protein disulfide isomerase [PDI], calnexin, calreticulin, endoplasmin, sarco/endoplasmic reticulum Ca2+-ATPase [SERCA]) that ..
  20. Gutierrez T, Simmen T. Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death. Cell Calcium. 2018;70:64-75 pubmed publisher
    ..Although not considered chaperones per se, the ER oxidoreductases of the protein disulfide isomerase (PDI) family complete the folding job by catalyzing the formation of disulfide bonds through cysteine oxidation...
  21. Chiarelli N, Carini G, Zoppi N, Ritelli M, Colombi M. Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome. PLoS ONE. 2018;13:e0191220 pubmed publisher
    ..Furthermore, the altered distribution of the ER marker protein disulfide isomerase PDI and the strong reduction of the COLLs-modifying enzyme FKBP22 are consistent with the disturbance of ER-related ..
  22. Wang H, Shao Y, Zhang W, Li C, Lv Z, Jin C. Molecular characterization of two novel molecular chaperones in bacterial-challenged Apostichopus japonicus. Gene. 2015;570:141-9 pubmed publisher
    Molecular chaperones of 78 kDa glucose-regulated protein (GRP78) and protein disulfide isomerase (PDI) are involved in protein folding and assembly in the endoplasmic reticulum (ER)...
  23. Langsjoen R, Auguste A, Rossi S, Roundy C, Penate H, Kastis M, et al. Host oxidative folding pathways offer novel anti-chikungunya virus drug targets with broad spectrum potential. Antiviral Res. 2017;143:246-251 pubmed publisher
    ..of the E1 and E2 envelope glycoproteins, and likely depend on host protein disulfide isomerase-family enzymes (PDI) to aid in facilitating disulfide bond formation and isomerization in these proteins...
  24. Lumb R, Bulleid N. Is protein disulfide isomerase a redox-dependent molecular chaperone?. EMBO J. 2002;21:6763-70 pubmed
    Protein disulfide isomerase (PDI) is a multifunctional protein catalysing the formation of disulfide bonds, acting as a molecular chaperone and being a component of the enzymes prolyl 4-hydroxylase (P4H) and microsomal triglyceride ..
  25. Carmello J, Dovigo L, Mima E, Jorge J, de Souza Costa C, Bagnato V, et al. In vivo evaluation of photodynamic inactivation using Photodithazine® against Candida albicans. Photochem Photobiol Sci. 2015;14:1319-28 pubmed publisher
    ..albicans to induce oral candidosis. After five days, photodynamic inactivation (PDI) mediated by PDZ at concentrations of 75, 100, 125 and 150 mg L(-1) was applied on the tongue of mice...
  26. Guan Y, Qin Y, Sun Y, Chen J, Xu W, Zhu D. Donor-acceptor co-assembled supramolecular nanofibers with high and well-balanced ambipolar charge transport properties under ambient conditions. Chem Commun (Camb). 2016;52:4648-51 pubmed publisher
    ..nanofiber based OFETs were fabricated from co-assembled supramolecular nanofibers which comprise TCAT and PDI-13, using a simple gelation method...
  27. Dangre P, Gilhotra R, Dhole S. Formulation and statistical optimization of self-microemulsifying drug delivery system of eprosartan mesylate for improvement of oral bioavailability. Drug Deliv Transl Res. 2016;6:610-21 pubmed publisher
    ..S mix (X 2), whereas the dependent variables were emulsification time (s), globule size (nm), polydispersity index (pdi), and zeta potential (mV), and the multiple linear regression analysis (MLRA) was employed to understand the ..
  28. Helal H, Mortada S, Sallam M. Paliperidone-Loaded Nanolipomer System for Sustained Delivery and Enhanced Intestinal Permeation: Superiority to Polymeric and Solid Lipid Nanoparticles. AAPS PharmSciTech. 2017;18:1946-1959 pubmed publisher
    ..An optimized lipomer formulation possessed a particle size of 168 nm, PDI of 0.2, zeta potential of -23 mV and an encapsulation efficiency of 87.27% ± 0.098...
  29. Cho K, Cho S, Lee S, Oh C, Kang K, Ryoo J, et al. Redox-regulated peptide transfer from the transporter associated with antigen processing to major histocompatibility complex class I molecules by protein disulfide isomerase. Antioxid Redox Signal. 2011;15:621-33 pubmed publisher
    ..In this study, we investigated the possible role of protein disulfide isomerase (PDI) as a peptide carrier between TAP and MHC-I...
  30. Alibolandi M, Sadeghi F, Abnous K, Atyabi F, Ramezani M, Hadizadeh F. The chemotherapeutic potential of doxorubicin-loaded PEG-b-PLGA nanopolymersomes in mouse breast cancer model. Eur J Pharm Biopharm. 2015;94:521-31 pubmed publisher
    ..The PEG-PLGA nanopolymersomes were 134±1.2nm spherical NPs with a narrow size distribution (PDI=0.121)...
  31. Zhao Z, Eberhart L, Orfe L, Lu S, Besser T, Call D. Genome-Wide Screening Identifies Six Genes That Are Associated with Susceptibility to Escherichia coli Microcin PDI. Appl Environ Microbiol. 2015;81:6953-63 pubmed publisher
    The microcin PDI inhibits a diverse group of pathogenic Escherichia coli strains. Coculture of a single-gene knockout library (BW25113; n=3,985 mutants) against a microcin PDI-producing strain (E...
  32. Miller T, Zak V, Shrader P, Ravishankar C, Pemberton V, Newburger J, et al. Growth Asymmetry, Head Circumference, and Neurodevelopmental Outcomes in Infants with Single Ventricles. J Pediatr. 2016;168:220-5.e1 pubmed publisher
    ..Associations between growth indices and scores on the Psychomotor Developmental Index (PDI) and Mental Developmental Index (MDI) of the Bayley Scales of Infant Development-II (BSID-II) at 14 months were ..
  33. Mahmoud M, Samy W. Enhanced Periodontal Regeneration by Novel Single Application Sustained Release Nano-Structured Doxycycline Films. Curr Drug Deliv. 2016;13:899-908 pubmed
    ..The formed particles had a zeta potential of + 13.8 mV and particle size of 52.86 nm with a polydispersity of PDI=0.946. No significant drug/polymer interaction was detected by DSC thermal analysis...
  34. Shang P, Lu G, Sun X, Bian Z, Shang Z, Li J. The influence of continuous glucose monitoring of high-risk neonate on guiding perinatal complications and one-year follow-up results. Eur Rev Med Pharmacol Sci. 2016;20:125-8 pubmed
    ..The mental development index (MDI) and the physical development index (PDI) of hypoglycemic group were significantly lower than those in the normal group and differences were statistically ..
  35. Nasr A, Gardouh A, Ghorab M. Novel Solid Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) for Oral Delivery of Olmesartan Medoxomil: Design, Formulation, Pharmacokinetic and Bioavailability Evaluation. Pharmaceutics. 2016;8: pubmed publisher
    ..91-22.97 nm) with optimum PDI values (0.036-0.241). All formulae also showed rapid emulsification time (15.46 ± 1.34-24.17 ± 1...
  36. Gandara L, Mamone L, Dotto C, Buzzola F, Casas A. Sae regulator factor impairs the response to photodynamic inactivation mediated by Toluidine blue in Staphylococcus aureus. Photodiagnosis Photodyn Ther. 2016;16:136-141 pubmed publisher
    Photodynamic inactivation (PDI) involves the combined use of light and a photosensitizer, which, in the presence of oxygen, originates cytotoxic species capable of inactivating bacteria...
  37. Hadmojo W, Yim D, Aqoma H, Ryu D, Shin T, Kim H, et al. Artificial light-harvesting n-type porphyrin for panchromatic organic photovoltaic devices. Chem Sci. 2017;8:5095-5100 pubmed publisher
    ..The n-type acceptor, PDI-PZn-PDI, was designed by connecting a zinc porphyrin (PZn) core to two perylenediimide (PDI) ..
  38. Kenche H, Ye Z, Vedagiri K, Richards D, Gao X, Tew K, et al. Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase. J Biol Chem. 2016;291:4763-78 pubmed publisher
    ..An increase in the levels of protein-disulfide isomerase (PDI), a multifaceted endoplasmic reticulum resident chaperone, has been demonstrated in human smokers, presumably as a ..
  39. Al Mahrouqi D, Vinogradov J, Jackson M. Zeta potential of artificial and natural calcite in aqueous solution. Adv Colloid Interface Sci. 2017;240:60-76 pubmed publisher
    ..5-11. Several studies have suggested that SO42- is also a PDI for the calcite surface, but new data presented here indicate that the value of pSO4 may affect zeta ..
  40. Stopa J, Neuberg D, Puligandla M, Furie B, Flaumenhaft R, Zwicker J. Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation. JCI Insight. 2017;2:e89373 pubmed publisher
    b>BACKGROUND: Protein disulfide isomerase (PDI) is required for thrombus formation...
  41. Nomura J, Hosoi T, Kaneko M, Ozawa K, Nishi A, Nomura Y. Neuroprotection by Endoplasmic Reticulum Stress-Induced HRD1 and Chaperones: Possible Therapeutic Targets for Alzheimer's and Parkinson's Disease. Med Sci (Basel). 2016;4: pubmed publisher
    ..examine the role of HMG-CoA reductase degradation protein 1 (HRD1) and the chaperone protein-disulfide isomerase (PDI), which are both produced in the ER in response to stress...
  42. Ahmed S, Gull A, Alam M, Aqil M, Sultana Y. Ultrasonically tailored, chemically engineered and "QbD" enabled fabrication of agomelatine nanoemulsion; optimization, characterization, ex-vivo permeation and stability study. Ultrason Sonochem. 2018;41:213-226 pubmed publisher
    ..The PDI, Zeta potential and the refractive index of optimized Ago-NE were found to be 0.137±0.016, -7.40±0.12mV and 1...
  43. Hu J, Shi Y, Wang C, Wan H, Wu D, Wang H, et al. Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury. Sci Rep. 2018;8:3201 pubmed publisher
    ..Mechanistically, ITF enhanced autophagy, reduces endoplasmic reticulum stress (ERS), and alleviates the impaired PDI, ASCT2, and B0AT1 in IECs and BBMVs after burn injury likely through AMPK activation...
  44. Ko H, Uehara T, Nomura Y. Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. J Biol Chem. 2002;277:35386-92 pubmed
    ..Previously, we found that protein-disulfide isomerase (PDI) is specifically up-regulated in response to hypoxia/brain ischemia in astrocytes...
  45. Flaumenhaft R. Protein disulfide isomerase as an antithrombotic target. Trends Cardiovasc Med. 2013;23:264-8 pubmed publisher
    Protein disulfide isomerase (PDI) is a ubiquitously expressed oxidoreductase required for proper protein folding. It is highly concentrated in the endoplasmic reticulum, but can also be released into the extracellular environment...
  46. Diwaker D, Mishra K, Ganju L, Singh S. Protein disulfide isomerase mediates dengue virus entry in association with lipid rafts. Viral Immunol. 2015;28:153-60 pubmed publisher
    ..This study investigated the interaction of host protein disulfide isomerase (PDI) with DENV proteins and role of lipid rafts in viral immunopathogenesis...
  47. Busch V, Loosli F, Santagapita P, Buera M, Stoll S. Formation of complexes between hematite nanoparticles and a non-conventional galactomannan gum. Toward a better understanding on interaction processes. Sci Total Environ. 2015;532:556-63 pubmed publisher
    ..VG showed a polydispersed size distribution (300-475 nm Z-average diameter, 0.65 Pdi) and a negative zeta potential (between -1 and -12 mV for pH2 and 12, respectively)...
  48. Seedat N, Kalhapure R, Mocktar C, Vepuri S, Jadhav M, Soliman M, et al. Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid-polymer hybrid nanoparticles: In vitro and in silico studies. Mater Sci Eng C Mater Biol Appl. 2016;61:616-30 pubmed publisher
    ..Results indicated rod-shaped LPNs with suitable size, PDI and zeta potential, while encapsulation efficiency (%EE) increased from 27.8% to 41.5%, 54.3% and 69...
  49. Luo B, Wang S, Rao R, Liu X, Xu H, Wu Y, et al. Conjugation Magnetic PAEEP-PLLA Nanoparticles with Lactoferrin as a Specific Targeting MRI Contrast Agent for Detection of Brain Glioma in Rats. Nanoscale Res Lett. 2016;11:227 pubmed publisher
    ..6?±?0.3, 165.7?±?0.6, and 218.2?±?0.4 nm, with polydispersity index (PDI) of 0.185?±?0.023, 0.192?±?0.021, and 0.224?±?0.036, respectively...
  50. Balzan R, Ephraums R, Delfabbro P, Andreou C. Beads task vs. box task: The specificity of the jumping to conclusions bias. J Behav Ther Exp Psychiatry. 2017;56:42-50 pubmed publisher
    ..Delusions Inventory (PDI) to assess for delusion-proneness. The number of 'draws to decision' was assessed for both tasks...
  51. Vuddanda P, Montenegro Nicolini M, Morales J, Velaga S. Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films. Eur J Pharm Sci. 2017;109:372-380 pubmed publisher
    ..Particle size (PS), polydispersity index (PDI), and zeta potential (ZP) of TDF nanosuspensions were measured in a Zetasizer...
  52. Baruah U, Gowthamarajan K, Ravisankar V, Karri V, Simhadri P, Singh V. Optimisation of chloroquine phosphate loaded nanostructured lipid carriers using Box-Behnken design and its antimalarial efficacy. J Drug Target. 2017;:1-16 pubmed publisher
    ..The optimised CQ loaded NLC showed a particle size of 66.50?±?1.21?nm, PDI of 0.210?±?0.016, ZP of +38.4?±?1.44 and EE of 78.2?±?1.2%, respectively...
  53. Farmer D, Thom E, Brock J, Burrows P, Johnson M, Howell L, et al. The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. Am J Obstet Gynecol. 2018;218:256.e1-256.e13 pubmed publisher
    ..Current data suggest that outcomes related to the need for shunting should be counseled separately from the outcomes related to distal neurologic functioning. ..
  54. Mazumdar S, Italiya K, Sharma S, Chitkara D, Mittal A. Effective cellular internalization, cell cycle arrest and improved pharmacokinetics of Tamoxifen by cholesterol based lipopolymeric nanoparticles. Int J Pharm. 2018;543:96-106 pubmed publisher
    ..TMX loaded lipopolymeric nanoparticles of particle size 151.25?±?3.74 (PDI 0.123) and entrapment efficiency of 73.62?±?3.08% were formulated...
  55. Wooten E, Iyer L, Montefusco M, Hedgepeth A, Payne D, Kapur N, et al. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. PLoS ONE. 2010;5:e8830 pubmed publisher
    ..Further, these studies demonstrate that leveraging existing expression and genomic data in the context of GWAS studies can identify biologically relevant genes and pathways associated with a congenital heart defect. ..
  56. Rullán M, Carvajal A, Núñez Córdoba J, Martínez M, Carrasco J, García I, et al. Spanish Version of the Patient Dignity Inventory: Translation and Validation in Patients With Advanced Cancer. J Pain Symptom Manage. 2015;50:874-81.e1 pubmed publisher
    The Patient Dignity Inventory (PDI) is an instrument to measure sources of distress related to dignity at the end of life. To obtain a Spanish version of the PDI and measure psychometric aspects in patients with advanced cancer...
  57. Bolinskey P, Smith E, Schuder K, Cooper Bolinskey D, Myers K, Hudak D, et al. Schizophrenia spectrum personality disorders in psychometrically identified schizotypes at two-year follow-up. Psychiatry Res. 2017;252:289-295 pubmed publisher
    ..Scales (CPPS), and were interviewed at baseline and follow-up with the Personality Disorder Interview for DSM-IV (PDI-IV)...
  58. Satija A, Bhupathiraju S, Spiegelman D, Chiuve S, Manson J, Willett W, et al. Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults. J Am Coll Cardiol. 2017;70:411-422 pubmed publisher
    ..We created an overall plant-based diet index (PDI) from repeated semiquantitative food-frequency questionnaire data, by assigning positive scores to plant foods and ..
  59. Raj M, Margabandu R, Mangalaraja R, Anandan S. Influence of imide-substituents on the H-type aggregates of perylene diimides bearing cetyloxy side-chains at bay positions. Soft Matter. 2017;13:9179-9191 pubmed publisher
    A series of perylene-3,4:9,10-tetracarboxylic acid diimides (PDIs, namely TYR-PDI, AEP-PDI, CET-PDI, ANP-PDI and KOD-PDI), comprising long linear cetyloxy side-chains functionalized at the 1,7-bay positions and the different substituents ..
  60. Rajpal G, Schuiki I, Liu M, Volchuk A, Arvan P. Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells. J Biol Chem. 2012;287:43-7 pubmed publisher
    ..Protein disulfide isomerase (PDI) has long been assumed to assist proinsulin in this process...
  61. Liu T, Hu X, Wang Y, Meng L, Zhou Y, Zhang J, et al. Triazine-based covalent organic frameworks for photodynamic inactivation of bacteria as type-II photosensitizers. J Photochem Photobiol B. 2017;175:156-162 pubmed publisher
    With the increase of antibiotic resistances in microorganisms, photodynamic inactivation (PDI) as a clinically proven antibacterial therapy is gaining increasing attention in recent years due to its high efficacy...
  62. Na K, Park B, Jang M, Cho S, Lee D, Kang S, et al. Protein disulfide isomerase is cleaved by caspase-3 and -7 during apoptosis. Mol Cells. 2007;24:261-7 pubmed
    ..Previously, using the proteomic approach, protein disulfide isomerase (PDI) was found to be a candidate substrate of caspase-7...
  63. Li Y, Hong J, Li H, Qi X, Guo Y, Han M, et al. Genkwanin nanosuspensions: a novel and potential antitumor drug in breast carcinoma therapy. Drug Deliv. 2017;24:1491-1500 pubmed publisher
    ..The obtained GKA-NSps had an average particle size of 183.1?±?4.4?nm, a PDI value of 0.16?±?0.07, a zeta potential of -16.2?±?0.1?mV, and a drug loading content of 49.36?±?0.14%...
  64. Chaves L, Costa Lima S, Vieira A, Barreiros L, Segundo M, Ferreira D, et al. Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability. Eur J Pharm Sci. 2018;112:28-37 pubmed publisher
    ..among process and formulation parameters and the selected responses were particle size, polydispersity index (PDI), association efficiency (AE) and drug loading (DL)...
  65. Basak D, Pal D, Sakurai T, Yoneda S, Seki S, Ghosh S. Cooperative supramolecular polymerization of a perylene diimide derivative and its impact on electron-transporting properties. Phys Chem Chem Phys. 2017;19:31024-31029 pubmed publisher
    H-bonding-promoted supramolecular polymerization of a perylene diimide (PDI) building block and its impact on charge carrier mobility were studied...
  66. Remelli W, Santabarbara S, Carbonera D, Bonomi F, Ceriotti A, Casazza A. Iron Binding Properties of Recombinant Class A Protein Disulfide Isomerase from Arabidopsis thaliana. Biochemistry. 2017;56:2116-2125 pubmed publisher
    The protein disulfide isomerase (PDI) family comprises a wide set of enzymes mainly involved in thiol-disulfide exchange reactions in the endoplasmic reticulum...
  67. Kutlehria S, Behl G, Patel K, Doddapaneni R, Vhora I, Chowdhury N, et al. Cholecalciferol-PEG Conjugate Based Nanomicelles of Doxorubicin for Treatment of Triple-Negative Breast Cancer. AAPS PharmSciTech. 2018;19:792-802 pubmed publisher
    ..DOX-loaded PEGCCF (PEGCCF-DOX) micelles have particle size, polydispersity index (PDI), and zeta potential of 40 ± 8.7 nm, 0.180 ± 0.051, and 2.39 ± 0.157 mV, respectively...
  68. Fu X, Zhu B. Human pancreas-specific protein disulfide-isomerase (PDIp) can function as a chaperone independently of its enzymatic activity by forming stable complexes with denatured substrate proteins. Biochem J. 2010;429:157-69 pubmed publisher
    ..In the present paper, we report that the chaperone activity of the human pancreas-specific PDI homologue (PDIp) is independent of its enzymatic activity on the basis of the following lines of evidence...
  69. Ren G, Jiang M, Guo W, Sun B, Lian H, Wang Y, et al. Construction and cellular uptake behavior of redox-sensitive docetaxel prodrug-loaded liposomes. Pharm Dev Technol. 2018;23:22-32 pubmed publisher
    ..process were optimized using entrapment efficiency (EE), drug-loading (DL), particle size and polydispersity index (PDI) as the evaluation indices...
  70. Imanparast F, Faramarzi M, Vatannejad A, Paknejad M, Deiham B, Kobarfard F, et al. mZD7349 peptide-conjugated PLGA nanoparticles directed against VCAM-1 for targeted delivery of simvastatin to restore dysfunctional HUVECs. Microvasc Res. 2017;112:14-19 pubmed publisher
    ..The study showed that mZD7349-SIM-PLGA-NPs have particle size, zeta potential value, polydispersity index (PDI) and encapsulation efficacy % of 233±18nm, -9.6±1.1mV, 0.59±0.066 and 69±17.3%, respectively...
  71. Cui Z, Huang J, Peng Q, Yu D, Wang S, Liang D. Risk assessment for human health in a seleniferous area, Shuang'an, China. Environ Sci Pollut Res Int. 2017;24:17701-17710 pubmed publisher
    ..The probable daily intake (PDI) was calculated on the basis of Se contents in food, water, and dietary habits to evaluate the risk of selenosis...
  72. Nakajima S, Saijo Y, Miyashita C, Ikeno T, Sasaki S, Kajiwara J, et al. Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children: Sapporo cohort study. Environ Res. 2017;159:222-231 pubmed publisher
    ..levels of 10 DLC isomers were significantly negatively associated with the Psychomotor Developmental Index (PDI) at 6 months of age after adjustment for potential confounding variables...
  73. van Nispen tot Pannerden H, van Dijk S, Du V, Heijnen H. Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activation. Blood. 2009;114:4738-40 pubmed publisher
    ..that encryption of TF and initiation of coagulation are facilitated by the enzyme protein disulfide isomerase (PDI), possibly on the surface of activated platelets or endothelial cells...
  74. Kushwah V, Agrawal A, Dora C, Mallinson D, Lamprou D, Gupta R, et al. Novel Gemcitabine Conjugated Albumin Nanoparticles: a Potential Strategy to Enhance Drug Efficacy in Pancreatic Cancer Treatment. Pharm Res. 2017;34:2295-2311 pubmed publisher
    ..2 ± 7.3, PDI 0.16 ± 0.06 and ZP -19.2 ± 1.4...
  75. Jiao Y, Liu K, Wang G, Wang Y, Zhang X. Supramolecular free radicals: near-infrared organic materials with enhanced photothermal conversion. Chem Sci. 2015;6:3975-3980 pubmed publisher
    ..Perylene diimide (PDI) can undergo chemical reduction to generate PDI radical anions...
  76. Clissold P, Bicknell R. The thioredoxin-like fold: hidden domains in protein disulfide isomerases and other chaperone proteins. Bioessays. 2003;25:603-11 pubmed
    Although protein disulphide isomerase (PDI) has been known for nearly 40 years, several new PDIs have recently been described that reveal a remarkable diversity in both structure and function...
  77. Wang C, Chen S, Wang X, Wang L, Wallis A, Freedman R, et al. Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance. J Biol Chem. 2010;285:26788-97 pubmed publisher
    Protein disulfide isomerase (PDI), which consists of multiple domains arranged as abb'xa'c, is a key enzyme responsible for oxidative folding in the endoplasmic reticulum...
  78. Peña E, Arderiu G, Badimon L. Protein disulphide-isomerase A2 regulated intracellular tissue factor mobilisation in migrating human vascular smooth muscle cells. Thromb Haemost. 2015;113:891-902 pubmed publisher
    Protein-disulphide isomerase family (PDI) are an ER-stress protein that controls TF-procoagulant activity but its role in HVSMC migration and coronary artery disease remains to be elucidated...
  79. Leng D, Thanki K, Fattal E, Foged C, Yang M. Engineering of budesonide-loaded lipid-polymer hybrid nanoparticles using a quality-by-design approach. Int J Pharm. 2018;548:740-746 pubmed publisher
    ..CQAs), which included the intensity-based hydrodynamic particle diameter (z-average), the polydispersity index (PDI), the zeta-potential, the budesonide encapsulation efficiency, the actual budesonide loading and the DOTAP ..
  80. Chen D, Zhu Y, Zhang Y, Wang L, Wei Y. [Preparation and in vitro evaluation of rhein-loaded PEG-PCL-PEI nanoparticles]. Zhongguo Zhong Yao Za Zhi. 2017;42:3121-3130 pubmed publisher
    ..3±3.6) nm in particle size with PDI of (0.19±0.08), Zeta potential of (6.3±1.5) mV, entrapment efficiency of (93.64±5.28)%, and drug loading of (8...
  81. Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K. Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease. Brain Res. 2010;1349:90-6 pubmed publisher
    ..Protein disulfide isomerase (PDI) is a member of the thioredoxin (TX) superfamily and is believed to accelerate the folding of disulfide-bonded ..
  82. Haefliger S, Klebig C, Schaubitzer K, Schardt J, Timchenko N, Mueller B, et al. Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML. Blood. 2011;117:5931-40 pubmed publisher
    ..this study, we screened for additional CEBPA mRNA binding proteins and we identified protein disulfide isomerase (PDI), an endoplasmic reticulum (ER) resident protein, to bind to the CEBPA mRNA stem loop region...
  83. Witayaudom P, Klinkesorn U. Effect of surfactant concentration and solidification temperature on the characteristics and stability of nanostructured lipid carrier (NLC) prepared from rambutan (Nephelium lappaceum L.) kernel fat. J Colloid Interface Sci. 2017;505:1082-1092 pubmed publisher
    ..zeta-potential (ζ-potential) and particle size (Z-average) with no significant effect on the polydispersity index (PDI)...
  84. Elnaggar Y, Etman S, Abdelmonsif D, Abdallah O. Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity. J Pharm Sci. 2015;104:3544-3556 pubmed publisher
    ..Formula optimization was based on particle size (PS), zeta potential (ZP), polydispersity index (PDI), % entrapment efficiency (% EE), release studies, and transmission electron microscopy...
  85. Jones M, Wu X, Chaudhuri J, Davidson M, Ellis M. Zirconium amine tris(phenolate): A more effective initiator for biomedical lactide. Mater Sci Eng C Mater Biol Appl. 2017;80:69-74 pubmed publisher
    ..The zirconium-catalyzed PLA (PLA-Zr) required 30min, resulting in a polydispersity index (PDI) of 1.17, compared to 1h and PDI=1.77 for tin-catalyzed PLA (PLA-Sn)...
  86. Zhang Y, Yue Y, Chang M. Local anaesthetic pain relief therapy: In vitro and in vivo evaluation of a nanotechnological formulation co-loaded with ropivacaine and dexamethasone. Biomed Pharmacother. 2017;96:443-449 pubmed publisher
    ..The results showed that the NPs was around 190nm, with PDI of less than 0.20. The zeta potentials of NPs were about 36mV...
  87. Wang L, He D, Wang S, Dai Y, Ju J, Zhao C. Preparation and evaluation of Curcumin-loaded self-assembled micelles. Drug Dev Ind Pharm. 2017;:1-17 pubmed publisher
    ..Conclusions The prepared SSCMs were characterized by PS, PDI, LE%, EE% data analysis...
  88. Duan Y, Xu X, Li Y, Li Z, Peng Q. Chalcogen-Atom-Annulated Perylene Diimide Trimers for Highly Efficient Nonfullerene Polymer Solar Cells. Macromol Rapid Commun. 2017;38: pubmed publisher
    This communication reports the synthesis of two novel chalcogen-atom-annulated perylene diimide (PDI) trimers with twisted structures, TriPDI-S and TriPDI-Se, for efficient nonfullerene polymer solar cells...
  89. Do B, Nguyen M, Song J, Park S, Yoo J, Jang J, et al. Soluble Prokaryotic Expression and Purification of Bioactive Tumor Necrosis Factor-related Apoptosis-inducing Ligand. J Microbiol Biotechnol. 2017;: pubmed publisher
    ..protein (MBP), b'a' domain of protein disulfide isomerase (PDIb'a'), or protein disulfide isomerase (PDI) at the N-terminus of TRAIL...
  90. Gao G, Liang N, Geng H, Jiang W, Fu H, Feng J, et al. Spiro-Fused Perylene Diimide Arrays. J Am Chem Soc. 2017;139:15914-15920 pubmed publisher
    ..of broadened and intensive absorption, aligned LUMO levels, and unique molecular geometry, the spiro-fused PDI system represents a new kind of high-performance semiconducting framework as the electron acceptor in high-..
  91. Karuppuswamy P, Chen H, Wang P, Hsu C, Wong K, Chu C. The three-dimensional-structure of twisted benzo[ghi]perylene-triimide dimer as a non-fullerene acceptor for inverted perovskite solar cells. ChemSusChem. 2017;: pubmed publisher
    ..ETL layer was applied in our perovskite solar cells with structure of glass/ITO/PEDOT:PSS/perovskite/BPTI/C60 or PDI-C4/BCP/Al. Use of a double ETL layer structure can effectively eliminate the leakage current...
  92. Donnier Maréchal M, Galanos N, Grandjean T, Pascal Y, Ji D, Dong L, et al. Perylenediimide-based glycoclusters as high affinity ligands of bacterial lectins: synthesis, binding studies and anti-adhesive properties. Org Biomol Chem. 2017;15:10037-10043 pubmed publisher
    ..The fluorescence properties of the PDI core were then investigated by confocal microscopy on cell-bacteria cultures...