PDHX

Summary

Gene Symbol: PDHX
Description: pyruvate dehydrogenase complex component X
Alias: DLDBP, E3BP, OPDX, PDHXD, PDX1, proX, pyruvate dehydrogenase protein X component, mitochondrial, dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, lipoyl-containing pyruvate dehydrogenase complex component X, pyruvate dehydrogenase complex, E3-binding protein subunit, pyruvate dehydrogenase complex, lipoyl-containing component X
Species: human
Products:     PDHX

Top Publications

  1. Tajir M, Arnoux J, Boutron A, Elalaoui S, de Lonlay P, Sefiani A, et al. Pyruvate dehydrogenase deficiency caused by a new mutation of PDHX gene in two Moroccan patients. Eur J Med Genet. 2012;55:535-40 pubmed publisher
    ..We describe two unrelated Moroccan patients with the same new mutation c.1182 + 2T > C in the E3 binding protein gene PDHX and different clinical forms.
  2. Mine M, Brivet M, Schiff M, de Baulny H, Chuzhanova N, Marsac C. A novel gross deletion caused by non-homologous recombination of the PDHX gene in a patient with pyruvate dehydrogenase deficiency. Mol Genet Metab. 2006;89:106-10 pubmed
    ..E3BP subunit was undetectable on Western blot. The sequence of exons 1-9 and exon 11 of the PDHX gene were normal, but exon 10 was impossible to amplify with standard PCR. Long-range PCR including exons 9-11 (11...
  3. Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, et al. JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice. Gastroenterology. 2018;154:1480-1493 pubmed publisher
    ..administered by gavage to mice with xenograft tumors, C57BL/6 mice with orthographic pancreatic tumors grown from Pdx1-Cre;KRasG12D/+;Tp53R172H/+ (KPC) cells, mice with metastases following tail-vein injection of ..
  4. Calise S, Zheng B, Hasegawa T, Satoh M, Isailovic N, Ceribelli A, et al. Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies. Clin Chem Lab Med. 2018;: pubmed publisher
    ..AMA-REF reacted with E2/E3, E3BP, E1α and E1β subunits of the pyruvate dehydrogenase complex by IP and western blotting and was positive for ..
  5. Xie Y, Zhu S, Zhong M, Yang M, Sun X, Liu J, et al. Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. Gastroenterology. 2017;153:1429-1443.e5 pubmed publisher
    ..We derived cells from tumors that developed in Pdx1-Cre;K-RasG12D/+;p53R172H/+ (KPC) mice...
  6. Gundala N, Naidu V, Das U. Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo. Nutrition. 2017;35:61-80 pubmed publisher
    ..Changes in the antioxidant content, lipid peroxides, nitric oxide, and expression of PDX1, P65, nuclear factor-?b (NF-?b), and IKB genes in STZ-treated RIN5 F cells in vitro and Nrf2, GLUT2, COX2, iNOS ..
  7. Wang S, Xu Z, Yin H, Min Y, Li S. Alleviation Mechanisms of Selenium on Cadmium-Spiked in Chicken Ovarian Tissue: Perspectives from Autophagy and Energy Metabolism. Biol Trace Elem Res. 2018;186:521-528 pubmed publisher
    ..of glucose-related genes including hexokinase II (HK2), pyruvate kinase (PK), pyruvate dehydrogenase complex (PDHX), and succinate dehydrogenase (SDH) and the activities of ATPase, including Na+-K+-ATPase, Ca<..
  8. Laine L, Biddau M, Byron O, Muller S. Biochemical and structural characterization of the apicoplast dihydrolipoamide dehydrogenase of Plasmodium falciparum. Biosci Rep. 2015;35: pubmed publisher
    ..A homology model for PfaE3 reveals an extra anti-parallel β-strand at the position where human E3BP (E3-binding protein) interacts with E3; a parasite-specific feature that may be exploitable for drug discovery ..
  9. Kel A, Boyarskikh U, Stegmaier P, Leskov L, Sokolov A, Yevshin I, et al. Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer. BMC Bioinformatics. 2019;20:119 pubmed publisher
    ..The markers include hypermethylated positions in regulatory regions of the following genes: CALCA, ENO1, MYC, PDX1, TCF7, ZNF43.

More Information

Publications155 found, 100 shown here

  1. Gundala N, Naidu V, Das U. Arachidonic acid and lipoxin A4 attenuate alloxan-induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo. Biofactors. 2017;43:251-271 pubmed publisher
    ..Expression of PDX1, P65 NF-kB and IKB in RIN5F cells and Nrf2, GLUT2, COX2, iNOS protein levels in the pancreatic tissue and plasma ..
  2. Herrou J, Willett J, Czyz D, Babnigg G, Kim Y, Crosson S. Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria. J Bacteriol. 2017;199: pubmed publisher
    ..a class II periplasmic binding protein fold with significant structural homology to Archaeoglobus fulgidus ProX, which binds glycine betaine...
  3. Liao J, Hwang S, Li H, Liu J, Hammock B, Yang G. Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG¹²D/Pdx-1-Cre Mice. Anticancer Res. 2016;36:27-37 pubmed
    ..on inhibiting the development of pancreatitis and pancreatic intraepithelial neoplasia (mPanIN) in LSL-Kras(G12D)/Pdx1-Cre mice...
  4. Niibo M, Shirouchi B, Umegatani M, Morita Y, Ogawa A, Sakai F, et al. Probiotic Lactobacillus gasseri SBT2055 improves insulin secretion in a diabetic rat model. J Dairy Sci. 2019;102:997-1006 pubmed publisher
    ..The plasma C-peptide levels and pancreatic mRNA levels of insulin genes (Ins1 and Ins2) and Pdx1 (a transcriptional factor of insulin genes) were increased in LG2055 diet-fed rats...
  5. Wu R, Cao L, Mattson E, Witwer K, Cao J, Zeng H, et al. Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice. Aging Cell. 2017;16:125-135 pubmed publisher
    ..Moreover, DNA damage and senescence responses were enhanced and Pdx1 and MafA mRNA expression were reduced in pancreas of the Se-deficient mice...
  6. Shojima N, Hara K, Fujita H, Horikoshi M, Takahashi N, Takamoto I, et al. Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice. Diabetologia. 2012;55:3318-30 pubmed publisher
    ..Levels of PDX1 and GSK-3β phosphorylation were significantly decreased in Hipk3 ( -/- ..
  7. Good A, Cannon C, Haemmerle M, Yang J, Stanescu D, Doliba N, et al. JUND regulates pancreatic β cell survival during metabolic stress. Mol Metab. 2019;: pubmed publisher
    ..ChIP-qPCR was used to determine chromatin enrichment. TRAP-seq in a PDX1-deficiency model of β cell dysfunction uncovered a cohort of genes regulated at the level of mRNA translation, ..
  8. Merry T, Tran M, Stathopoulos M, Wiede F, Fam B, Dodd G, et al. High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage. Antioxid Redox Signal. 2014;20:2114-29 pubmed publisher
    ..The decreased insulin secretion was associated with reduced islet β cell pancreatic and duodenal homeobox-1 (Pdx1) and insulin content, elevated pancreatic PTP oxidation (including PTPN2 oxidation), and elevated signal transducer ..
  9. Wu H, Liu Y, Wang H, Xu X. High-fat diet induced insulin resistance in pregnant rats through pancreatic pax6 signaling pathway. Int J Clin Exp Pathol. 2015;8:5196-202 pubmed
    ..of Pax6 transcription factor and its target genes in pancreas, such as pancreatic and duodenal homeobox factor-1 (Pdx1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) and glucose transporter 2 (Glut2) were decreased ..
  10. Vasu S, Ojo O, Moffett R, Conlon J, Flatt P, Abdel Wahab Y. Anti-diabetic actions of esculentin-2CHa(1-30) and its stable analogues in a diet-induced model of obesity-diabetes. Amino Acids. 2017;49:1705-1717 pubmed publisher
    ..Peptide treatments had beneficial effects on expression of islet genes (Ins1, Slc2a2, Pdx1) and skeletal muscle genes involved in insulin action (Slc2a4, Pdk1, Irs1, Akt1)...
  11. Balakumar M, Raji L, Prabhu D, Sathishkumar C, Prabu P, Mohan V, et al. High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress. Mol Cell Biochem. 2016;423:93-104 pubmed
    ..Transcription factors of ?-cell function (INSIG1, SREBP1c and PDX1) as well as hepatic gluconeogenesis (FOXO1 and PEPCK) were adversely affected in diet-induced insulin-resistant ..
  12. Yamaguchi J, Mino Kenudson M, Liss A, Chowdhury S, Wang T, Fernández Del Castillo C, et al. Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice. Gastroenterology. 2016;151:1232-1244.e10 pubmed publisher
    ..We performed mitochondrial DNA mutational mapping studies to determine the cell lineage and fate of PDG cells. Pdx1-Cre;LSL-KRASG12D (KC) mice were bred with TFF2-knockout mice to generate KC/Tff2-/- and KC/..
  13. Wang D, Ding X, Xue W, Zheng J, Tian X, Li Y, et al. A new scaffold containing small intestinal submucosa and mesenchymal stem cells improves pancreatic islet function and survival in vitro and in vivo. Int J Mol Med. 2017;39:167-173 pubmed publisher
    ..controls, as well as with the increased the expression of insulin 1 (Ins1), pancreatic and duodenal homeobox 1 (Pdx1), platelet endothelial cell adhesion molecule 1 [Pecam1; also known as cluster of differentiation 31 (CD31)] ..
  14. Shi J, Zhu C, Liu J, Sun J, Rao G, Li A. [Recombinant hFOXA2 and hPDX1 lentivirus induced dental pulp stem cells from deciduous teeth reprogramming for insulin-producing cells]. Shanghai Kou Qiang Yi Xue. 2013;22:634-42 pubmed
    ..Immunofluorescence staining was used to measure the expression of proinsulin, FOXA2 and PDX1. ELISA method was used to detect the insulin secretion. The data was analyzed Using SPSS13.0 software package...
  15. Kang R, Xie Y, Zhang Q, Hou W, Jiang Q, Zhu S, et al. Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer. Cell Res. 2017;27:916-932 pubmed publisher
    ..K-Ras signaling activation, prevent cancer development and metastasis/invasion, and prolong animal survival in Pdx1-Cre;K-RasG12D/+;Hmgb1-/- mice...
  16. Fazeli W, Karakaya M, Herkenrath P, Vierzig A, Dotsch J, von Kleist Retzow J, et al. Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis. Mol Cell Pediatr. 2016;3:22 pubmed publisher
    ..On day 27 of life, we identified a homozygous stop mutation in the PDHX gene, causing pyruvate dehydrogenase E3-binding protein deficiency...
  17. Bhattacharya S, Oksbjerg N, Young J, Jeppesen P. Caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion and glucose sensitivity in INS-1E cells. Diabetes Obes Metab. 2014;16:602-12 pubmed publisher
    ..glucose transporter 2), Gck (glucokinase), Ins1 (insulin 1), Ins2, Beta2 (neurogenic differentiation protein 1), Pdx1 (pancreatic and duodenal homeobox protein 1), Akt1 (RAC-α serine/threonine-protein kinase encoding gene), Akt2 (..
  18. Sharma A, Rani R. Do we really need to differentiate mesenchymal stem cells into insulin-producing cells for attenuation of the autoimmune responses in type 1 diabetes: immunoprophylactic effects of precursors to insulin-producing cells. Stem Cell Res Ther. 2017;8:167 pubmed publisher
    ..Expression of the PDX1 gene in pIPCs was assessed using Western blot and fluorescence-activated cell sorting (FACS)...
  19. Albury Warren T, Pandey V, Spinel L, Masternak M, Altomare D. Prediabetes linked to excess glucagon in transgenic mice with pancreatic active AKT1. J Endocrinol. 2016;228:49-59 pubmed publisher
    ..We previously showed that mice with myristoylated Akt1 (AKT1(Myr)) expressed through a bicistronic Pdx1-TetA and TetO-MyrAkt1 system were susceptible to islet cell carcinomas, and in this study we characterized an early ..
  20. Ding Y, Li Z, Cheng X, Ran Y, Wu S, Shi Y, et al. Dityrosine administration induces dysfunction of insulin secretion accompanied by diminished thyroid hormones T3 function in pancreas of mice. Amino Acids. 2017;49:1401-1414 pubmed publisher
    ..glucose-stimulated insulin secretion by upregulating mRNA levels of insulin synthesis-related genes (Ins2, MafA, Pdx1) and T3 action-related genes, as well as increasing protein level of TRβ1...
  21. Ferriero R, Boutron A, Brivet M, Kerr D, Morava E, Rodenburg R, et al. Phenylbutyrate increases pyruvate dehydrogenase complex activity in cells harboring a variety of defects. Ann Clin Transl Neurol. 2014;1:462-70 pubmed publisher
    ..have defects in the X-linked E1-α gene but defects in the other components of the complex encoded by PDHB, PDHX, DLAT, DLD genes or in the regulatory enzyme encoded by PDP1 have also been found...
  22. Karunakaran U, Elumalai S, Moon J, Jeon J, Kim N, Park K, et al. Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5. Diabetes Metab J. 2019;43:192-205 pubmed publisher
    ..ATPase 2b (SERCA2b) gene expression and reduced the nuclear accumulation of pancreatic duodenal homeobox 1 (PDX1) leads to β-cell apoptosis...
  23. Wilson L, Wong S, Yu N, Geras Raaka E, Raaka B, Gershengorn M. Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. Stem Cells. 2009;27:2703-11 pubmed publisher
    ..factors known to induce transcription of this gene in beta cells, pancreatic and duodenal homeobox factor 1 (Pdx1), V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (Mafa), and neurogenic differentiation 1 (Neurod1), ..
  24. Johnson C, Peat J, Volante S, Wang R, McLean C, Pin C. Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. J Pathol. 2012;228:351-65 pubmed publisher
    ..R26r acini showed increased acinar dedifferentiation, formation of ductal cysts and transient increases in PDX1 expression compared to wild-type acinar cells...
  25. Calvani J, Lopez P, Sarnacki S, Molina T, Gibault L, Fabre M, et al. Solid pseudopapillary neoplasms of the pancreas do not express major pancreatic markers in pediatric patients. Hum Pathol. 2019;83:29-35 pubmed publisher
    ..It is now well known that the undifferentiated PDX1+ pancreatic progenitors proliferate and differentiate into endocrine, ductal, and acinar cells, thanks to the ..
  26. Shaer A, Azarpira N, Vahdati A, Karimi M, Shariati M. miR-375 induces human decidua basalis-derived stromal cells to become insulin-producing cells. Cell Mol Biol Lett. 2014;19:483-99 pubmed publisher
    ..The expressions of insulin, NGN3, GLUT2, PAX4, PAX6, KIR6.2, NKX6.1, PDX1, and glucagon genes were evaluated using real-time qPCR...
  27. Kara B, Genç H, Uyur Yalçın E, Sakarya Güneş A, Topçu U, Mülayim S, et al. Pyruvate dehydrogenase-E1α deficiency presenting as recurrent acute proximal muscle weakness of upper and lower extremities in an 8-year-old boy. Neuromuscul Disord. 2017;27:94-97 pubmed publisher
    ..Thiamine was ordered (15 mg/kg/day), dietary carbohydrates were restricted and clinical findings improved in a few weeks. This rare phenotype of PDHC deficiency is discussed. ..
  28. Fiory F, Lombardi A, Miele C, Giudicelli J, Beguinot F, Van Obberghen E. Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E. Diabetologia. 2011;54:2941-52 pubmed publisher
    ..Further, the insulin- and glucose-induced expression of Ins1, Gck and Pdx1 mRNA was abolished by MGO. Finally, MGO blocked glucose-induced insulin secretion and PI3K/PKB pathway activation...
  29. Johnson J, Kono T, Tong X, Yamamoto W, Zarain Herzberg A, Merrins M, et al. Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell. J Biol Chem. 2014;289:32798-810 pubmed publisher
    ..To determine whether restoration of SERCA2b could rescue ER stress induced by Pdx-1 loss, Pdx1(+/-) mice were fed a high-fat diet...
  30. Khan M, Nazir F, Asgher M, Per T, Khan N. Selenium and sulfur influence ethylene formation and alleviate cadmium-induced oxidative stress by improving proline and glutathione production in wheat. J Plant Physiol. 2015;173:9-18 pubmed publisher
    ..accumulation as a result of increased activity of glutamyl kinase (GK) and decreased activity of proline oxidase (PROX)...
  31. Zheng Y, Lei Q, Jongejan A, Mulder C, van Daalen S, Mastenbroek S, et al. The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells. DNA Repair (Amst). 2018;70:55-66 pubmed publisher
    ..For instance, we found that the transcription factor PDX1 was specifically expressed in undifferentiated spermatogonia and thus may be a novel marker for these cells...
  32. Boutant M, Ramos O, Tourrel Cuzin C, Movassat J, Ilias A, Vallois D, et al. COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways. PLoS ONE. 2012;7:e30847 pubmed publisher
    ..mice were generated and crossed with mice expressing Cre under the control of pancreatic duodenal homeobox 1 (pdx1) gene promoter. Ablation of COUP-TFII in pancreas resulted in glucose intolerance...
  33. Bathina S, Das U. Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats. Lipids Health Dis. 2018;17:168 pubmed publisher
    ..Gene expression of Nf-kB, IkB, Bax, Bcl-2 and Pdx1 gene was studied invitro by qRT-PCR in RIN5F cells. In STZ (65 mg/kg i.p...
  34. Mato E, Lucas M, Petriz J, Gomis R, Novials A. Identification of a pancreatic stellate cell population with properties of progenitor cells: new role for stellate cells in the pancreas. Biochem J. 2009;421:181-91 pubmed publisher
    ..cell clusters occurred during cell expansion and they showed weak expression of the transcription factor Pdx1 (pancreatic and duodenal homeobox 1)...
  35. Besseiche A, Riveline J, Gautier J, Breant B, Blondeau B. Metabolic roles of PGC-1α and its implications for type 2 diabetes. Diabetes Metab. 2015;41:347-57 pubmed publisher
    ..PGC-1α also is associated with glucocorticoid receptors in repressing expression of Pdx1, a key β-cell transcription factor...
  36. Green A, Vasu S, McClenaghan N, Flatt P. Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells. Pflugers Arch. 2015;467:2219-28 pubmed publisher
    ..of gene expression by reverse-transcription, real-time PCR showed that genes involved with insulin secretion (INS, PDX1, PCSK1, PCSK2, GLP1R and GIPR), cell-cell communication (GJD2, GJA1 and CDH1) and antioxidant defence (SOD1, SOD2, ..
  37. Jurczyk A, Nowosielska A, Przewozniak N, Aryee K, Diiorio P, Blodgett D, et al. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β. FASEB J. 2016;30:983-93 pubmed publisher
    ..Insulin secretion was reduced (0.5 vs. 0.1 ng/ml; P < 0.05), and critical β-cell transcription factors Pdx1 and Nkx6.1 were significantly decreased...
  38. Dygai A, Skurikhin E, Pershina O, Ermakova N, Krupin V, Ermolaeva L, et al. Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus. Bull Exp Biol Med. 2016;160:474-9 pubmed publisher
    ..oligopotent progenitor β-cells (CD45(-), TER119(-), CD133(+), and CD49f(low)), and insulinproducing β-cells (Pdx1(+))...
  39. Ceribelli A, Isailovic N, De Santis M, Generali E, Satoh M, Selmi C. Detection of anti-mitochondrial antibodies by immunoprecipitation in patients with systemic sclerosis. J Immunol Methods. 2018;452:1-5 pubmed publisher
    ..The four proteins were identified as the proteins X/E3BP, E1α, E1β, and E2/E3 of the pyruvate dehydrogenase antigen complex by immunoprecipitation-Western blot...
  40. Kaitsuka T, Tomizawa K. Cell-Penetrating Peptide as a Means of Directing the Differentiation of Induced-Pluripotent Stem Cells. Int J Mol Sci. 2015;16:26667-76 pubmed publisher
    ..lineage from mouse and human pluripotent stem cells via the protein transduction of three transcription factors, Pdx1, NeuroD, and MafA...
  41. KIMMEL R, Dobler S, Schmitner N, Walsen T, Freudenblum J, Meyer D. Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment. Sci Rep. 2015;5:14241 pubmed publisher
    ..In this work, we characterize pancreatic islet development and function in zebrafish mutant for pdx1, a gene which in humans is linked to genetic forms of diabetes and is associated with increased susceptibility to ..
  42. Kondratyeva L, Didych D, Chernov I, Kopantzev E, Stukacheva E, Vinogradova T, et al. Dependence of expression of regulatory master genes of embryonic development in pancreatic cancer cells on the intracellular concentration of the master regulator PDX1. Dokl Biochem Biophys. 2017;475:259-263 pubmed publisher
    Exogenous expression of the gene encoding the pancreatic master regulator PDX1 in cell lines with different degrees of differentiation of pancreatic cancer cells is accompanied by changes in the expression of known master genes involved ..
  43. Du Z, Uversky V. A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes. Int J Mol Sci. 2017;18: pubmed publisher
    ..several computational tools for the intrinsic disorder characterization revealed that IRS1, IRS2, IRS4, MAFA, PDX1, ADIPO, PIK3R2, PIK3R5, SoCS1, and SoCS3 are expected to be highly disordered, whereas VDCC, SoCS2, SoCS4, JNK9, ..
  44. Dawes L, Shelley E, McAvoy J, Lovicu F. A role for Hippo/YAP-signaling in FGF-induced lens epithelial cell proliferation and fibre differentiation. Exp Eye Res. 2018;169:122-133 pubmed publisher
    ..detect the expression of Hippo-signaling components, Total and Phosphorylated YAP, as well as fibre cell markers, Prox-1 and β-crystallin...
  45. Kawasaki A, Itoh S, Shima K, Kato K, Ohashi H, Ishikawa T, et al. Change in the crystalline structure during the phase transition of the palladium-hydrogen system. Phys Chem Chem Phys. 2015;17:24783-90 pubmed publisher
    ..Fast growth of the β phase was observed at around x = 0.1 and x = 0.45 of PdHx, and the phase transition rate has an exponential behavior in between...
  46. Purohit A, Varney M, Rachagani S, Ouellette M, Batra S, Singh R. CXCR2 signaling regulates KRAS(G¹²D)-induced autocrine growth of pancreatic cancer. Oncotarget. 2016;7:7280-96 pubmed publisher
    ..Progressively increasing expression of mCXCR2 and its ligands was detected in the malignant ductal cells of Pdx1-cre;LSL-Kras(G12D) mice...
  47. Lokmic Z. Isolation, Identification, and Culture of Human Lymphatic Endothelial Cells. Methods Mol Biol. 2016;1430:77-90 pubmed publisher
    ..LEC and LM LEC purity is determined immunohistochemically using cell surface markers CD31, CD34, podoplanin, VEGFR-3 and nuclear marker PROX-1. Cells whose purity is >98 % are used for experiments between passage 4 and 6.
  48. Ahangarpour A, Afshari G, Mard S, Khodadadi A, Hashemitabar M. Preventive effects of procyanidin A2 on glucose homeostasis, pancreatic and duodenal homebox 1, and glucose transporter 2 gene expression disturbance induced by bisphenol A in male mice. J Physiol Pharmacol. 2016;67:243-52 pubmed
    ..A2 (PCA2) against glucose homeostasis disturbance and gene expression of pancreatic and duodenal homebox 1 (Pdx1) as well as glucose transporter 2 (Glut2) induced by BPA in male mice...
  49. Neelankal John A, Ram R, Jiang F. RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/db. Endocr Pathol. 2018;29:207-221 pubmed publisher
    ..A reduction in both insulin secretion and the expression of Ins1, Ins2, Glut2, Pdx1 and MafA was indicative of dedifferentiation in db/db islets...
  50. Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, et al. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. elife. 2013;2:e00940 pubmed publisher
    ..Expression of the cardinal islet developmental regulators Neurog3, MafA, Pdx1 and Pax6 converted exocrine duct cells into endocrine progeny with hallmark β-cell properties, including the ..
  51. Taha M, Javeri A, Majidizadeh T, Valojerdi M. Both BMP4 and serum have significant roles in differentiation of embryonic stem cells to primitive and definitive endoderm. Cytotechnology. 2016;68:1315-24 pubmed publisher
    ..Quantitative real-time PCR analysis showed higher expression levels of Sox17, Pdx1, Cdx2 and Villin mRNAs in the KoSR plus BMP4 condition and higher Gata4 and Afp expression levels in the FBS plus ..
  52. Sasaki S, Miyatsuka T, Matsuoka T, Takahara M, Yamamoto Y, Yasuda T, et al. Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice. Diabetologia. 2015;58:2582-91 pubmed publisher
    ..beta cells expressed beta cell specific transcription factors, such as pancreatic and duodenal homeobox 1 (PDX1), NK6 homeobox 1 (NKX6.1) and musculoaponeurotic fibrosarcoma oncogene family A (MafA)...
  53. Gopinathan A, Morton J, Jodrell D, Sansom O. GEMMs as preclinical models for testing pancreatic cancer therapies. Dis Model Mech. 2015;8:1185-200 pubmed publisher
    ..different GEMMs of human pancreatic cancer, with a focus on the Lox-Stop-Lox (LSL)-Kras(G12D); LSL-Trp53(R172H); Pdx1-cre (KPC) model, one of the most widely used preclinical models for this disease...
  54. Shih H, Seymour P, Patel N, Xie R, Wang A, Liu P, et al. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Rep. 2015;13:326-36 pubmed publisher
    ..Here, we identify Pdx1 and Sox9 as cooperative inducers of a gene regulatory network that distinguishes the pancreatic from the intestinal ..
  55. Xu J, Cui J, del Campo A, Shin C. Four and a Half LIM Domains 1b (Fhl1b) Is Essential for Regulating the Liver versus Pancreas Fate Decision and for β-Cell Regeneration. PLoS Genet. 2016;12:e1005831 pubmed publisher
    ..and intestinal cells, contributed to the liver by directly or indirectly modulating the discrete levels of pdx1 expression in endodermal progenitors...
  56. Trott J, Tan E, Ong S, Titmarsh D, Denil S, Giam M, et al. Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells. Stem Cell Reports. 2017;8:1675-1688 pubmed publisher
    ..These cultured pancreatic progenitor (cPP) cells express key pancreatic transcription factors, including PDX1 and SOX9, and exhibit transcriptomes closely related to their in vivo counterparts...
  57. Villamayor L, Rodríguez Seguel E, Araujo R, Carrasco M, Bru Tari E, Mellado Gil J, et al. GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells. Diabetes. 2018;67:448-460 pubmed publisher
    ..We also demonstrate that Pdx1 expression in adult β-cells depends on GATA sites in transgenic reporter mice and that loss of GATA6 greatly ..
  58. Miller B, Morton J, Pinese M, Saturno G, Jamieson N, McGhee E, et al. Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Mol Med. 2015;7:1063-76 pubmed publisher
    ..We found that LOX expression is upregulated in metastatic tumors from Pdx1-Cre Kras(G12D/+) Trp53(R172H/+) (KPC) mice and that inhibition of LOX in these mice suppressed metastasis...
  59. Catenacci D, Junttila M, Karrison T, Bahary N, Horiba M, Nattam S, et al. Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer. J Clin Oncol. 2015;33:4284-92 pubmed publisher
    ..biologic mechanisms of SMO inhibition, two autochthonous pancreatic cancer models (Kras(G12D); p16/p19(fl/fl); Pdx1-Cre and Kras(G12D); p53(R270H/wt); Pdx1-Cre) were studied...
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    ..HMGB1?, MPO?, CD68?, IL-4?, IL-10?, and TGF-??) and enhanced regeneration of damaged pancreas (Reg4?, PTF1?, and PDX1?) are also promoted. But these effects diminish or disappear after antagonizing miR-9 (TuD)...
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    ..Moreover, APNtg-DHT mice displayed increased pancreatic mRNA levels of insulin receptors, Pdx1 and Igf1R, suggesting adiponectin stimulates beta cell viability/hyperplasia in the context of PCOS...
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    ..Insulin secretion was measured by ELISA. Insulin expression and some islet factors were evaluated by RT-PCR. PDX1, a marker for ?-cell function and differentiation, was evaluated by both immunocytochemistry and Western blot...
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    ..and classified as follows: FC-Dist, free carina (no links connected to a carina) and distal cell re-wiring; CC-Prox, connected to a carina (the presence of a link connected to a central carina) and proximal cell rewiring; CC-Dist, ..
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    ..By interbreeding conditional LsL-Trp53R172H,LsL-KrasG12D and Pdx1-Cre strains, we obtained LsL-KrasG12D;LsL-Trp53R172H;Pdx1-Cre(KPC), LsL-KrasG12D;..
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