PDGFR beta

Summary

Gene Symbol: PDGFR beta
Description: platelet derived growth factor receptor beta
Alias: CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT, platelet-derived growth factor receptor beta, Activated tyrosine kinase PDGFRB, CD140 antigen-like family member B, NDEL1-PDGFRB, PDGF-R-beta, PDGFR-beta, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor, beta polypeptide
Species: human
Products:     PDGFR beta

Top Publications

  1. Seifert R, Hart C, Phillips P, Forstrom J, Ross R, Murray M, et al. Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem. 1989;264:8771-8 pubmed
    ..Both the absolute and relative numbers of these two PDGF receptor subunits vary on different cell types and correspond to differences in the mitogenic sensitivity of cells to the different PDGF isoforms. ..
  2. Waters C, Sambi B, Kong K, Thompson D, Pitson S, Pyne S, et al. Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. J Biol Chem. 2003;278:6282-90 pubmed
  3. Hewitt K, Shamis Y, Knight E, Smith A, Maione A, Alt Holland A, et al. PDGFR? expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation. J Cell Sci. 2012;125:2276-87 pubmed publisher
    Platelet-derived growth factor receptor-beta (PDGFR?) is required for the development of mesenchymal cell types, and plays a diverse role in the function of fibroblasts in tissue homeostasis and regeneration...
  4. Nicolas G, Pottier C, Charbonnier C, Guyant Marechal L, Le Ber I, Pariente J, et al. Phenotypic spectrum of probable and genetically-confirmed idiopathic basal ganglia calcification. Brain. 2013;136:3395-407 pubmed publisher
    ..Other biomarkers may be helpful in better predicting clinical expression. ..
  5. Ustach C, Huang W, Conley LaComb M, Lin C, Che M, Abrams J, et al. A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer. Cancer Res. 2010;70:9631-40 pubmed publisher
    Increasing evidence indicates the significance of platelet-derived growth factor receptor-? (?-PDGFR) signaling in prostate cancer (PCa)...
  6. Chi S, Vetiska S, Gill R, Hsiung M, Liu F, Van Tol H. Transactivation of PDGFRbeta by dopamine D4 receptor does not require PDGFRbeta dimerization. Mol Brain. 2010;3:22 pubmed publisher
    ..Hence, the DRD4-PDGFRbeta-ERK1/2 pathway can occur independently of a PDGF-like ligand, PDGFRbeta cross-phosphorylation and dimerization, which is distinct from other known forms of transactivation of RTKs by GPCRs. ..
  7. Trojani A, Ripamonti C, Penco S, Beghini A, Nadali G, Di Bona E, et al. Molecular analysis of PDGFRA and PDGFRB genes by rapid single-strand conformation polymorphism (SSCP) in patients with core-binding factor leukaemias with KIT or FLT3 mutation. Anticancer Res. 2008;28:2745-51 pubmed
    ..The aim of this study was to investigate if PDGFR mutations are involved in CBFL...
  8. Heldin C, Ostman A, Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta. 1998;1378:F79-113 pubmed
    ..Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel. ..
  9. Cheung Y, Gayden T, Campeau P, LeDuc C, Russo D, Nguyen V, et al. A recurrent PDGFRB mutation causes familial infantile myofibromatosis. Am J Hum Genet. 2013;92:996-1000 pubmed publisher
    ..b>PDGFR-? promotes growth of mesenchymal cells, including blood vessels and smooth muscles, which are affected in IM...

More Information

Publications86

  1. Veevers Lowe J, Ball S, Shuttleworth A, Kielty C. Mesenchymal stem cell migration is regulated by fibronectin through ?5?1-integrin-mediated activation of PDGFR-? and potentiation of growth factor signals. J Cell Sci. 2011;124:1288-300 pubmed publisher
    ..Here, we report extracellular matrix (ECM)-directed crosstalk between platelet-derived growth factor receptor (PDGFR)-? and ?5?1-integrin, which controls the migration of mesenchymal stem (stromal) cells (MSCs)...
  2. Dolloff N, Shulby S, Nelson A, Stearns M, Johannes G, Thomas J, et al. Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha platelet-derived growth factor receptor. Oncogene. 2005;24:6848-54 pubmed
    ..This difference in PDGF responsiveness depends on the higher expression of alpha-PDGFR in bone-metastatic compared to nonmetastatic prostate cells and the lack of alpha-PDGFR expression in normal and ..
  3. Toffalini F, Kallin A, Vandenberghe P, Pierre P, Michaux L, Cools J, et al. The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation. Haematologica. 2009;94:1085-93 pubmed publisher
    ..We have shown that chimeric receptor tyrosine kinases escape ubiquitination and down-regulation and that their stabilization is critical to efficient stimulation of cell proliferation. ..
  4. Estevez Garcia P, Castaño A, Martin A, Lopez Rios F, Iglesias J, Muñoz Galvan S, et al. PDGFR?/? and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome. BMC Cancer. 2012;12:514 pubmed publisher
    ..VEGFR and PDGFR are key players involved in this process...
  5. Wehler T, Frerichs K, Graf C, Drescher D, Schimanski K, Biesterfeld S, et al. PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy. Oncol Rep. 2008;19:697-704 pubmed
    ..03). In summary, our results revealed that PDGFRalpha/beta expression significantly correlates with lymphatic dissemination and therefore encourages application of PDGFRalpha/beta RTK-inhibitors within a combination therapy. ..
  6. Erben P, Horisberger K, Muessle B, Müller M, Treschl A, Ernst T, et al. mRNA expression of platelet-derived growth factor receptor-beta and C-KIT: correlation with pathologic response to cetuximab-based chemoradiotherapy in patients with rectal cancer. Int J Radiat Oncol Biol Phys. 2008;72:1544-50 pubmed publisher
    ..Cetuximab-based chemoradiotherapy increased PDGFRbeta levels even further compared with the pretreatment samples and deserves further investigation. ..
  7. Lennartsson J, Wardega P, Engstrom U, Hellman U, Heldin C. Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation. J Biol Chem. 2006;281:39152-8 pubmed
    ..Our data suggest that Alix inhibits down-regulation of PDGFRbeta by modulating the interaction between c-Cbl and the receptor, thereby affecting the ubiquitination of the receptor. ..
  8. Chiara F, Bishayee S, Heldin C, Demoulin J. Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail. J Biol Chem. 2004;279:19732-8 pubmed
    ..These findings indicate that allosteric inhibition of the PDGF beta-receptor by its C-terminal tail is one of the mechanisms involved in keeping the receptor inactive in the absence of ligand. ..
  9. Kumar A, Salimath B, Stark G, Finkenzeller G. Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A. 2010;16:983-93 pubmed publisher
    ..From these experiments, we conclude that PDGF receptor signaling sustains proliferation without affecting osteogenic differentiation of MSCs. ..
  10. Matsumoto T, Yokote K, Take A, Takemoto M, Asaumi S, Hashimoto Y, et al. Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. Biochem Biophys Res Commun. 2000;270:28-33 pubmed
    ..The differential binding of CrkII to the PDGF alpha- and beta- receptors may be a rationale for functional diversity between the two receptors. ..
  11. Sánchez Contreras M, Baker M, Finch N, Nicholson A, Wojtas A, Wszolek Z, et al. Genetic screening and functional characterization of PDGFRB mutations associated with basal ganglia calcification of unknown etiology. Hum Mutat. 2014;35:964-71 pubmed publisher
    ..of the platelet-derived growth factor receptor family type ?, and PDGFB, encoding PDGF-B, the specific ligand of PDGFR?, were found implicating the PDGF-B/PDGFR? pathway in abnormal brain calcification...
  12. Claesson Welsh L, Eriksson A, Moren A, Severinsson L, Ek B, Ostman A, et al. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol Cell Biol. 1988;8:3476-86 pubmed
    ..Binding assays with different 125I-labeled dimeric forms of PDGF A and B chains showed that the PDGF receptor expressed in CHO cells bound PDGF-BB and, to a lesser extent, PDGF-AB, but not PDGF-AA. ..
  13. Freedman N, Kim L, Murray J, Exum S, Brian L, Wu J, et al. Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization. J Biol Chem. 2002;277:48261-9 pubmed
    ..Specificity of GRK2 for receptor protein-tyrosine kinases, expressed at physiologic levels, may be determined by the ability of these receptors to activate heterotrimeric G proteins, among other factors. ..
  14. Nicolas G, Pottier C, Maltete D, Coutant S, Rovelet Lecrux A, Legallic S, et al. Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification. Neurology. 2013;80:181-7 pubmed publisher
    ..To identify a new idiopathic basal ganglia calcification (IBGC)-causing gene...
  15. Kruk J, Vasefi M, Liu H, Heikkila J, Beazely M. 5-HT(1A) receptors transactivate the platelet-derived growth factor receptor type beta in neuronal cells. Cell Signal. 2013;25:133-43 pubmed publisher
    ..This crosstalk between 5-HT and PDGF? receptors identifies a potentially important signaling link between the serotonergic system and growth factor signaling in neurons. ..
  16. Kim Y, Kim E, Wu Q, Guryanova O, Hitomi M, Lathia J, et al. Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes Dev. 2012;26:1247-62 pubmed publisher
    ..While PDGFR? alterations inform intertumoral heterogeneity toward a proneural glioblastoma (GBM) subtype, we interrogated the ..
  17. Gilbertson D, Duff M, West J, Kelly J, Sheppard P, Hofstrand P, et al. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem. 2001;276:27406-14 pubmed
    ..Together, these studies describe a third member of the PDGF family (PDGF-C) as a potent mitogen for cells of mesenchymal origin in in vitro and in vivo systems with a binding pattern similar to PDGF-AB. ..
  18. Choi M, Lee I, Kim G, Kim B, Han Y, Yu D, et al. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature. 2005;435:347-53 pubmed
    ..Prx II deficiency results in increased production of H2O2, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cgamma1, and subsequently increased cell proliferation and migration in response to PDGF...
  19. Gronwald R, Grant F, Haldeman B, Hart C, O Hara P, Hagen F, et al. Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. Proc Natl Acad Sci U S A. 1988;85:3435-9 pubmed
    ..This observation is consistent with the existence of more than one PDGF receptor class. ..
  20. Martignetti J, Tian L, Li D, Ramirez M, Camacho Vanegas O, Camacho S, et al. Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis. Am J Hum Genet. 2013;92:1001-7 pubmed publisher
  21. Weissmueller S, Manchado E, Saborowski M, Morris J, Wagenblast E, Davis C, et al. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor ? signaling. Cell. 2014;157:382-394 pubmed publisher
    ..Finally, high PDGFRb expression correlates with poor disease-free survival in pancreatic, colon, and ovarian cancer patients, implicating PDGFRb as a prognostic marker and possible target for attenuating metastasis in p53 mutant tumors...
  22. Reddi A, Ying G, Duan L, Chen G, Dimri M, Douillard P, et al. Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. J Biol Chem. 2007;282:29336-47 pubmed
    ..Cbl as an E3 ubiquitin ligase for ubiquitinylation and degradation of platelet-derived growth factor receptor (PDGFR) alpha and PDGFRbeta...
  23. Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore P, Dikic I. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol. 2003;5:461-6 pubmed
    ..Thus, monoubiquitination is the principal signal responsible for the movement of RTKs from the plasma membrane to the lysosome. ..
  24. Toffalini F, Hellberg C, Demoulin J. Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein. J Biol Chem. 2010;285:12268-78 pubmed publisher
    The fusion of TEL with platelet-derived growth factor receptor (PDGFR) beta (TPbeta) is found in a subset of patients with atypical myeloid neoplasms associated with eosinophilia and is the archetype of a larger group of hybrid receptors ..
  25. Kodama M, Kitadai Y, Sumida T, Ohnishi M, Ohara E, Tanaka M, et al. Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor ? is associated with lymphatic metastasis in human gastric carcinoma. Cancer Sci. 2010;101:1984-9 pubmed publisher
    ..Blockade of PDGF-R signaling pathways may inhibit lymph node metastasis of gastric carcinoma. ..
  26. Nupponen N, Paulsson J, Jeibmann A, Wrede B, Tanner M, Wolff J, et al. Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas. Mod Pathol. 2008;21:265-70 pubmed
  27. Suzuki S, Dobashi Y, Hatakeyama Y, Tajiri R, Fujimura T, Heldin C, et al. Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-? phosphorylation, and microvessel density in gastric cancer. BMC Cancer. 2010;10:659 pubmed publisher
    ..was to define: i) the expression pattern of VEGF-A and PDGF-B in tumor cells and the activation of PDGF receptor (PDGFR)-? tyrosine kinase in stromal cells of human gastric adenocarcinomas; and ii) the relationship between VEGF-A and ..
  28. Moores S, Selfors L, Fredericks J, Breit T, Fujikawa K, Alt F, et al. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000;20:6364-73 pubmed
    ..Thus, although each Vav isoform can respond to similar cell surface receptors, there are isoform-specific differences in their activation of downstream signaling pathways. ..
  29. Garbelli R, de Bock F, Medici V, Rousset M, Villani F, Boussadia B, et al. PDGFRβ(+) cells in human and experimental neuro-vascular dysplasia and seizures. Neuroscience. 2015;306:18-27 pubmed publisher
    ..Platelet-derived growth factor receptor beta (PDGFRβ) is used as a marker of perivascular pericytes...
  30. Cortez E, Gladh H, Braun S, Bocci M, Cordero E, Björkström N, et al. Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD. Proc Natl Acad Sci U S A. 2016;113:E864-73 pubmed publisher
    ..Aberrant platelet-derived growth factor receptor beta (PDGFRβ) signaling in cancer has motivated the development of several antagonists currently in clinical use, including ..
  31. Morrison D, Kaplan D, Escobedo J, Rapp U, Roberts T, Williams L. Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell. 1989;58:649-57 pubmed
    ..This is the first demonstration of the direct modulation of a protein activity by a growth factor receptor tyrosine kinase. ..
  32. Qin Y, Fortin J, Tye D, Gleason Guzman M, Brooks T, Hurley L. Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression. Biochemistry. 2010;49:4208-19 pubmed publisher
    To understand the mechanisms controlling platelet-derived growth factor receptor beta (PDGFR-beta) expression in malignancies, we have cloned and characterized the first functional promoter of the human PDGFR-beta gene, which has been ..
  33. Ham O, Lee S, Song B, Lee C, Lee J, Seo H, et al. Small molecule-mediated induction of miR-9 suppressed vascular smooth muscle cell proliferation and neointima formation after balloon injury. Oncotarget. 2017;8:93360-93372 pubmed publisher
    ..Here we report that both platelet-derived growth factor receptor (PDGFR) targeting miR-9 and a small molecule that increases miR-9 can inhibit the serum-induced proliferation of VSMCs...
  34. Sparwel J, Vantler M, Caglayan E, Kappert K, Fries J, Dietrich H, et al. Differential effects of red and white wines on inhibition of the platelet-derived growth factor receptor: impact of the mash fermentation. Cardiovasc Res. 2009;81:758-70 pubmed publisher
    ..We investigated the effects of selected red and white wines on PDGF receptor (PDGFR) signalling in rat and human vascular smooth muscle cells (VSMCs)...
  35. Ball S, Worthington J, Canfield A, Merry C, Kielty C. Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential. Stem Cells. 2014;32:694-705 pubmed publisher
    ..Thus, MSC potency and vascular induction are regulated by perturbing mesenchymal fate. ..
  36. Tang Q, Zhai X, Tu Y, Wang P, Wang L, Wu C, et al. Synthesis and antiproliferative activity of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing the 2-oxo-4-chloro-1,2-dihydroquinoline-3-carboxamide moiety. Bioorg Med Chem Lett. 2016;26:1794-8 pubmed publisher
    ..1-fold increase in activity against H460 cell line in vitro. The enzymatic assays (c-Met, VEGFR-2, Flt-3, PDGFR-β, c-Kit, and EGFR) of compound 42 were evaluated in vitro...
  37. Boer J, den Boer M. BCR-ABL1-like acute lymphoblastic leukaemia: From bench to bedside. Eur J Cancer. 2017;82:203-218 pubmed publisher
    ..In this review, we discuss the types of tyrosine kinase-activating lesions discovered, and the preclinical and clinical evidence for the use of tyrosine kinase inhibitors in the treatment of this novel subtype of ALL. ..
  38. McCarthy N, Liu J, Richarte A, Eskiocak B, Lovely C, Tallquist M, et al. Pdgfra and Pdgfrb genetically interact during craniofacial development. Dev Dyn. 2016;245:641-52 pubmed publisher
    ..Developmental Dynamics 245:641-652, 2016. © 2016 Wiley Periodicals, Inc. ..
  39. Lubman O, Waksman G. Structural and thermodynamic basis for the interaction of the Src SH2 domain with the activated form of the PDGF beta-receptor. J Mol Biol. 2003;328:655-68 pubmed
    ..Surprisingly, we show that water plays a role in the recognition process. ..
  40. Salva E, Turan S, Akbuğa J. Inhibition of Glomerular Mesangial Cell Proliferation by siPDGF-B- and siPDGFR-β-Containing Chitosan Nanoplexes. AAPS PharmSciTech. 2017;18:1031-1042 pubmed publisher
    ..The objective of this study was to decrease mesangial cell proliferation by knocking down PDGF-B and its receptor, PDGFR-β...
  41. Yap K, Furtado L, Kiyotani K, Curran E, Stock W, McNeer J, et al. Diagnostic evaluation of RNA sequencing for the detection of genetic abnormalities associated with Ph-like acute lymphoblastic leukemia (ALL). Leuk Lymphoma. 2017;58:950-958 pubmed publisher
    ..While total RNAseq can be a second tier approach allowing discovery of novel genetic alterations, the targeted RNAseq workflow offers a clinically applicable method for the detection of fusion transcripts. ..
  42. Appiah Kubi K, Wang Y, Qian H, Wu M, Yao X, Wu Y, et al. Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment response biomarker with multifarious therapeutic targets in cancers. Tumour Biol. 2016;37:10053-66 pubmed publisher
    ..The oncologic alterations of the PDGFR/PDGF system affect the extracellular, transmembrane and tyrosine kinase domains as well as the juxtamembrane ..
  43. Superti Furga G, Fumagalli S, Koegl M, Courtneidge S, Draetta G. Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. EMBO J. 1993;12:2625-34 pubmed
    ..Moreover, the system we describe here allows for further study of the regulation of tyrosine kinases in a neutral background and in an organism amenable to genetic analysis. ..
  44. Kartha V, Stawski L, Han R, Haines P, Gallagher G, Noonan V, et al. PDGFR? Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas. PLoS ONE. 2016;11:e0154645 pubmed publisher
    ..matrix remodeling and tumor invasion and migration, including platelet-derived growth factor receptor beta (PDGFR?), which was found to be the highest-ranking receptor protein genome-wide...
  45. Spagnuolo R, Brich S, Bozzi F, Conca E, Castelli C, Tazzari M, et al. Sunitinib-induced morpho-functional changes and drug effectiveness in malignant solitary fibrous tumours. Oncotarget. 2016;7:45015-45026 pubmed publisher
    ..Finally, we also found that PDGFRB is one of the components of a complex that includes Beclin 1 and VPS34.The results of these tissue-based analyses provide new insights into sunitinib's mechanism of action in SFT patients. ..
  46. Rider S, Christian H, Mullins L, Howarth A, Macrae C, Mullins J. Zebrafish mesonephric renin cells are functionally conserved and comprise two distinct morphological populations. Am J Physiol Renal Physiol. 2017;312:F778-F790 pubmed publisher
    ..Our studies demonstrate substantive conservation of renin regulation across vertebrates, and ultrastructural studies of renin cells reveal at least two distinct morphologies of mesonephric perivascular ren-expressing cells. ..
  47. Balestri M, Crisafulli C, Donato L, Giegling I, Calati R, Antypa N, et al. Nine differentially expressed genes from a post mortem study and their association with suicidal status in a sample of suicide completers, attempters and controls. J Psychiatr Res. 2017;91:98-104 pubmed publisher
    ..Nevertheless, neurotrophic gene variants, in particular EFEMP1 and PTPRR, may have a role in the pathogenesis of suicidal behaviour. ..
  48. Weigel M, Meinhold Heerlein I, Bauerschlag D, Schem C, Bauer M, Jonat W, et al. Combination of imatinib and vinorelbine enhances cell growth inhibition in breast cancer cells via PDGFR beta signalling. Cancer Lett. 2009;273:70-9 pubmed publisher
    ..was performed to evaluate the effects of imatinib on breast cancer cell lines with respect to the activity of PDGFR beta and Akt: a downstream modulator of cell growth and survival...
  49. Huang L, Cohen A, Colman H, Jensen R, Fults D, Couldwell W. IGFBP2 expression predicts IDH-mutant glioma patient survival. Oncotarget. 2017;8:191-202 pubmed publisher
    ..We propose therefore that an unexpected biological consequence of IDH mutations in glioma is to ameliorate patient survival by promoting tumor-suppressor signaling while inhibiting that of oncogenes, particularly IGFBP2. ..
  50. Van Swearingen A, Sambade M, Siegel M, Sud S, McNeill R, Bevill S, et al. Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer. Neuro Oncol. 2017;19:1481-1493 pubmed publisher
  51. Fountas A, Diamantopoulos L, Tsatsoulis A. Tyrosine Kinase Inhibitors and Diabetes: A Novel Treatment Paradigm?. Trends Endocrinol Metab. 2015;26:643-56 pubmed publisher
    ..results in β cell survival and enhanced insulin secretion, while platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) inhibition leads to improvement in insulin sensitivity...
  52. Chen C, Liu S, Chen C, Chen P, Chen C. Human placenta-derived multipotent mesenchymal stromal cells involved in placental angiogenesis via the PDGF-BB and STAT3 pathways. Biol Reprod. 2015;93:103 pubmed publisher
    ..endothelial cells from umbilical veins for platelet-derived growth factor (PDGF)-BB expression and to induce hPMSC PDGFR-beta and STAT3 activation. Endothelial cells were co-cultured with hPMSCs for in vitro angiogenesis...
  53. Songyang Z, Gish G, Mbamalu G, Pawson T, Cantley L. A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains. J Biol Chem. 1995;270:26029-32 pubmed
    ..These results establish the importance of the beta D5 residue in determining specificities of SH2 domains. ..
  54. Teekamp N, van Dijk F, Broesder A, Evers M, Zuidema J, Steendam R, et al. Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGF?-receptor in the fibrotic kidney. Int J Pharm. 2017;534:229-236 pubmed publisher
    ..Altogether, we show that subcutaneously administered polymeric microspheres present a suitable sustained release drug delivery system for the controlled systemic delivery for proteins such as pPB-HSA. ..
  55. Plantamura I, Casalini P, Dugnani E, Sasso M, D Ippolito E, Tortoreto M, et al. PDGFR? and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells. Mol Oncol. 2014;8:968-81 pubmed publisher
    ..e. Sunitinib and Bevacizumab) or by siRNA-mediating silencing, allowed the identification of PDGFR? and FGFR2 as relevant players in this phenomenon...
  56. Hellberg C, Schmees C, Karlsson S, Ahgren A, Heldin C. Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling. Mol Biol Cell. 2009;20:2856-63 pubmed publisher
  57. Tanaka K, Nagayama Y, Nakano T, Takamura N, Namba H, Fukada S, et al. Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid. Endocrinology. 1998;139:852-8 pubmed
    ..Insulin-like growth factor I receptor, platelet-derived growth factor receptor (PDGFR), TrkE, Axl, epidermal growth factor receptor, etc...
  58. Wagner J, Wolf Yadlin A, Sevecka M, Grenier J, Root D, Lauffenburger D, et al. Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks. Sci Signal. 2013;6:ra58 pubmed publisher
    ..class constituting insulin-like growth factor 1 receptor and neurotrophic tyrosine receptor kinase 2; and (iii) a PDGFR? class constituting platelet-derived growth factor receptor ?...
  59. Lierman E, Lahortiga I, Van Miegroet H, Mentens N, Marynen P, Cools J. The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors. Haematologica. 2007;92:27-34 pubmed
    ..been shown to have activity against receptor tyrosine kinases from the platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR) families...
  60. Welin S, Fjällskog M, Saras J, Eriksson B, Janson E. Expression of tyrosine kinase receptors in malignant midgut carcinoid tumors. Neuroendocrinology. 2006;84:42-8 pubmed
    ..Therefore, these tumors might be susceptible for treatment with TKRI or monoclonal antibodies and this should be further explored in clinical trials. ..
  61. Dalvi P, Gupta V, Griffin B, O Brien Ladner A, Dhillon N. Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus-Transactivator of Transcription and Cocaine-Mediated Smooth Muscle Hyperplasia. Am J Respir Cell Mol Biol. 2015;53:336-45 pubmed publisher
    ..smooth muscle cells (SMCs), while also suggesting involvement of platelet-derived growth factor receptor (PDGFR) activation in the absence of further increase in PDGF-BB ligand...
  62. Roberts W, Look A, Roussel M, Sherr C. Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes. Cell. 1988;55:655-61 pubmed
    ..The as yet unidentified c-fms promoter/enhancer sequences may be confined to the nucleotides separating the two genes or could potentially lie within the PDGF receptor gene itself. ..
  63. Floege J, Eitner F, Alpers C. A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol. 2008;19:12-23 pubmed
    The PDGF system, comprising four isoforms (PDGF-A, -B, -C, and -D) and two receptor chains (PDGFR-alpha and -beta), plays important roles in wound healing, atherosclerosis, fibrosis, and malignancy...
  64. De Sepulveda P, Okkenhaug K, Rose J, Hawley R, Dubreuil P, Rottapel R. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 1999;18:904-15 pubmed
    ..These data suggest that Socs1 is an inducible switch which modulates proliferative signals in favour of cell survival signals and functions as an adaptor protein in receptor tyrosine kinase signalling pathways. ..
  65. Ronnstrand L, Arvidsson A, Kallin A, Rorsman C, Hellman U, Engstrom U, et al. SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis. Oncogene. 1999;18:3696-702 pubmed
  66. Chen J, Williams I, Kutok J, Duclos N, Anastasiadou E, Masters S, et al. Positive and negative regulatory roles of the WW-like domain in TEL-PDGFbetaR transformation. Blood. 2004;104:535-42 pubmed
    ..Therefore, the WW-like domain in the context of TELPDGFbetaR may have both positive and negative regulatory roles in kinase activation. ..
  67. Muhle Goll C, Hoffmann S, Afonin S, Grage S, Polyansky A, Windisch D, et al. Hydrophobic matching controls the tilt and stability of the dimeric platelet-derived growth factor receptor (PDGFR) ? transmembrane segment. J Biol Chem. 2012;287:26178-86 pubmed publisher
    ..The effect of hydrophobic mismatch might play a key role in the redistribution and activation of the receptor within different lipid microdomains of the plasma membrane in vivo. ..
  68. Finerty P, Mittermaier A, Muhandiram R, Kay L, Forman Kay J. NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain. Biochemistry. 2005;44:694-703 pubmed
    ..PLCC) binds the phosphorylated Tyr-1021 site (pTyr-1021) in the beta-platelet-derived growth factor receptor (PDGFR)...
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    ..coronary arteries showed markedly increased expression of LRP6 and colocalization with PDGF receptor ? (PDGFR-?)...
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    ..EWS tumor cells express the receptor tyrosine kinases, platelet-derived growth factor receptor (PDGFR) and c-KIT...
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    ..NHERFs were shown to interact directly with platelet-derived growth factor receptor (PDGFR), and we demonstrate the assembly of a ternary complex between PTEN, NHERFs and PDGFR...
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    ..in part, by vascular endothelial growth factor receptor 2 (VEGFR2), and platelet-derived growth factor receptor (PDGFR) ? and ?...
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    ..Furthermore, this desensitization appears to involve GRK2-mediated phosphorylation of PDGFRbeta Ser(1104), with consequent dissociation of the PDGFRbeta from NHERF. ..
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    ..of this study was to clarify the clinical implications of p53 and platelet-derived growth factor receptor-β (PDGFR-β) in pancreatic cancer using immunohistochemistry (IHC)...
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