Gene Symbol: PDGFB
Description: platelet derived growth factor subunit B
Alias: IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet-derived growth factor subunit B, PDGF subunit B, PDGF, B chain, becaplermin, platelet-derived growth factor 2, platelet-derived growth factor B chain, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog), platelet-derived growth factor, beta polypeptide (oncogene SIS), proto-oncogene c-Sis
Species: human
Products:     PDGFB

Top Publications

  1. Gharibi B, Ghuman M, Hughes F. Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFR?-induced MSC self-renewal. J Cell Mol Med. 2012;16:2789-801 pubmed publisher
    ..Thus, activation of multiple intracellular cascades is required for successful and sustainable MSC self-renewal strategies. ..
  2. Shimizu A, O Brien K, Sjoblom T, Pietras K, Buchdunger E, Collins V, et al. The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res. 1999;59:3719-23 pubmed
    ..and 22, which fuse the collagen type Ialpha1 (COLIA1) gene to the platelet-derived growth factor (PDGF) B-chain (PDGFB) gene...
  3. Siegfried G, Basak A, Prichett Pejic W, Scamuffa N, Ma L, Benjannet S, et al. Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases. Oncogene. 2005;24:6925-35 pubmed
    ..Our findings emphasize the importance of the convertase-directed processing of proPDGF-B at the RGRR81/ sequence for PDGF-B maturation and secretion. ..
  4. Peng F, Dhillon N, Yao H, Zhu X, Williams R, Buch S. Mechanisms of platelet-derived growth factor-mediated neuroprotection--implications in HIV dementia. Eur J Neurosci. 2008;28:1255-64 pubmed publisher
    ..Furthermore, PDGF-mediated protection also involved the inhibition of gp120-induced release of mitochondrial cytochrome C. Our findings thus underscore the roles of both PI3K/Akt and Bcl family pathways in PDGF-mediated neuroprotection. ..
  5. Hermansson M, Nister M, Betsholtz C, Heldin C, Westermark B, Funa K. Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Proc Natl Acad Sci U S A. 1988;85:7748-52 pubmed
    The genes for platelet-derived growth factor (PDGF) A chain, B chain/c-sis, and the PDGF receptor are expressed in human malignant glioma cell lines...
  6. Li X, Ponten A, Aase K, Karlsson L, Abramsson A, Uutela M, et al. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol. 2000;2:302-9 pubmed
  7. Gilbertson D, Duff M, West J, Kelly J, Sheppard P, Hofstrand P, et al. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem. 2001;276:27406-14 pubmed
    ..Together, these studies describe a third member of the PDGF family (PDGF-C) as a potent mitogen for cells of mesenchymal origin in in vitro and in vivo systems with a binding pattern similar to PDGF-AB. ..
  8. LaRochelle W, Jeffers M, McDonald W, Chillakuru R, Giese N, Lokker N, et al. PDGF-D, a new protease-activated growth factor. Nat Cell Biol. 2001;3:517-21 pubmed
    ..However, in cells expressing both PDGFRs, PDGF-D activates both receptors. This indicates that PDGFR-alpha activation may result from PDGFR-alpha/beta heterodimerization. ..
  9. Ullerås E, Wilcock A, Miller S, Franklin G. The sequential activation and repression of the human PDGF-B gene during chronic hypoxia reveals antagonistic roles for the depletion of oxygen and glucose. Growth Factors. 2001;19:233-45 pubmed
    ..We also show that a putative hypoxia response element in the PDGF-B promoter is not sufficient for hypoxic induction, although it does function as a hypoxia independent enhancer element in hepatocellular carcinoma cells. ..

More Information

Publications120 found, 100 shown here

  1. Takahira T, Oda Y, Tamiya S, Higaki K, Yamamoto H, Kobayashi C, et al. Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans. Mod Pathol. 2007;20:668-75 pubmed
    Fusion of the collagen type I alpha 1 (COL1A1) gene with the platelet-derived growth factor beta chain (PDGFB) gene has been described in dermatofibrosarcoma protuberans...
  2. Patel K, Szabo S, Hernandez V, Prieto V, Abruzzo L, Lazar A, et al. Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridiza. Hum Pathol. 2008;39:184-93 pubmed
    ..by a t(17;22) translocation or a supernumerary ring chromosome that results in the fusion of exon 2 of PDGFB to various exons of the COL1A1 gene...
  3. Peng F, Dhillon N, Callen S, Yao H, Bokhari S, Zhu X, et al. Platelet-derived growth factor protects neurons against gp120-mediated toxicity. J Neurovirol. 2008;14:62-72 pubmed publisher
    ..Taken together these findings lead us to suggest that PDGF-BB could be considered as a therapeutic agent that can mitigate gp120-mediated neurotoxicity in HAD. ..
  4. Donnem T, Al Saad S, Al Shibli K, Busund L, Bremnes R. Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer. Ann Oncol. 2010;21:223-31 pubmed publisher
    ..8, confidence interval 95% 2.80-8.31, P < 0.001). Tumor cell PDGF-A expression correlates with LNM, and the co-expression of PDGF-B and VEGFR-3 is strongly associated with poor survival in NSCLC patients. ..
  5. Llombart B, Sanmartin O, Lopez Guerrero J, Monteagudo C, Serra C, Requena C, et al. Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1-PDGFB ) study with therapeutic implications. Histopathology. 2009;54:860-72 pubmed publisher
    To analyse the presence of collagen type I alpha 1-platelet-derived growth factor beta (COL1A1-PDGFB) transcripts in 20 cases of dermatofibrosarcoma protuberans (DFSP) and to assess the relationship between COL1A1 breakpoints and ..
  6. Suzuki S, Dobashi Y, Hatakeyama Y, Tajiri R, Fujimura T, Heldin C, et al. Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-? phosphorylation, and microvessel density in gastric cancer. BMC Cancer. 2010;10:659 pubmed publisher
  7. Veevers Lowe J, Ball S, Shuttleworth A, Kielty C. Mesenchymal stem cell migration is regulated by fibronectin through ?5?1-integrin-mediated activation of PDGFR-? and potentiation of growth factor signals. J Cell Sci. 2011;124:1288-300 pubmed publisher
    ..This synergistic relationship between ?5?1-integrin and PDGFR-? is a fundamental determinant of cell migration. Thus, fibronectin-rich matrices can prime PDGFR-? to recruit mesenchymal cells at sites of vascular remodelling. ..
  8. Caplan A, Correa D. PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs. J Orthop Res. 2011;29:1795-803 pubmed publisher
    ..This thesis explains how PDGF functions as a powerful therapeutic agent for bone formation and repair. ..
  9. Qiao J, Patel K, Lopez Terrada D, Fang H. Atrophic dermatofibrosarcoma protuberans: report of a case demonstrated by detecting COL1A1-PDGFB rearrangement. Diagn Pathol. 2012;7:166 pubmed publisher
    ..Molecular analysis showed a fusion between COL1A1 exon 31 to exon 2 of PDGFB. The lesion was totally excised, with negative margins of the resection demonstrated by CD34 immunostaining...
  10. Zhu X, Yao H, Peng F, Callen S, Buch S. PDGF-mediated protection of SH-SY5Y cells against Tat toxin involves regulation of extracellular glutamate and intracellular calcium. Toxicol Appl Pharmacol. 2009;240:286-91 pubmed publisher
    ..These findings thus underscore the role of PDGF-mediated calcium signaling and Erk phosphorylation in the protection of cells against HIV Tat toxicity. ..
  11. Taglia I, Bonifati V, Mignarri A, Dotti M, Federico A. Primary familial brain calcification: update on molecular genetics. Neurol Sci. 2015;36:787-94 pubmed publisher
    ..To date, three causative genes have been found: SLC20A2, PDGFRB and PDGFB. SLC20A2 gene codes for the 'sodium-dependent phosphate transporter 2' (PiT-2), a cell membrane transporters of ..
  12. Koseła Paterczyk H, Rutkowski P. Dermatofibrosarcoma protuberans and gastrointestinal stromal tumor as models for targeted therapy in soft tissue sarcomas. Expert Rev Anticancer Ther. 2017;17:1107-1116 pubmed publisher
    ..DFSP is characterized, by chromosomal translocation which results in the formation of COL1A1-PDGFB fusion gene causing platelet-derived growth factor receptor beta(PDGFRB) signaling activation in tumor cells...
  13. Mathorne S, Sørensen K, Fagerberg C, Bode M, Hertz J. A novel PDGFRB sequence variant in a family with a mild form of primary familial brain calcification: a case report and a review of the literature. BMC Neurol. 2019;19:60 pubmed publisher
    ..Mutations in five genes have been identified so far including SLC20A2, PDGFRB, PDGFB, XPR1, and MYORG...
  14. Durante C, Tallini G, Puxeddu E, Sponziello M, Moretti S, Ligorio C, et al. BRAF(V600E) mutation and expression of proangiogenic molecular markers in papillary thyroid carcinomas. Eur J Endocrinol. 2011;165:455-63 pubmed publisher
    ..those harboring BRAF(V600E) exhibit downregulated VEGFA, VEGFR, and PDGFRβ expression, suggesting that the presence of BRAF mutation does not imply a stronger prediction of response to drugs targeting VEGF and PDGFB signaling pathways.
  15. Lee J, Lee W, Seol M, Lee S, Kim D, Kim H, et al. Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation. Oncotarget. 2016;7:66728-66739 pubmed publisher
    ..Mechanistically, up-regulation of LETM1 induced YAP1 nuclear accumulation, increasing the expression of PDGFB, PDGFRB and THBS4...
  16. Wang C, Yao X, Chen H, Lai J, Guo X, Su H, et al. Novel mutations of PDGFRB cause primary familial brain calcification in Chinese families. J Hum Genet. 2017;62:697-701 pubmed publisher
    ..20 member 2 (SLC20A2), platelet-derived growth factor receptor b (PDGFRB), platelet-derived growth factor b (PDGFB)and xenotropic and polytropic retrovirus receptor 1 (XPR1), have been identified to cause primary familial brain ..
  17. Zhang H, Hua Y, Jiang Z, Yue J, Shi M, Zhen X, et al. Cancer-associated Fibroblast-promoted LncRNA DNM3OS Confers Radioresistance by Regulating DNA Damage Response in Esophageal Squamous Cell Carcinoma. Clin Cancer Res. 2019;25:1989-2000 pubmed publisher
    ..Our study highlighted CAF-promoted DNM3OS as an attractive target to reverse tumor radioresistance in ESCC. ..
  18. Liu P, LU J, Cardoso W, Vaziri C. The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. Mol Biol Cell. 2008;19:248-61 pubmed
    ..Therefore, SMOC-2 contributes to cell cycle progression by maintaining ILK activity during G1. These results identify a novel role for SMOC-2 in cell cycle control. ..
  19. Fu P, Cong R, Chen S, Zhang L, Ding Z, Zhou Q, et al. [CONDITIONS OF SYNOVIAL MESENCHYMAL STEM CELLS DIFFERENTIATING INTO FIBROCARTILAGE CELLS]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015;29:81-91 pubmed
    ..0 with 2 level conditions and the cells were induced to differentiate on the small intestinal submucosa (SIS)-3D scaffold...
  20. Lim S, Esain V, Kwan W, Theodore L, Cortes M, Frost I, et al. HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Exp Hematol. 2017;46:83-95.e6 pubmed publisher
    ..Platelet-Derived Growth Factor B (pdgfb), a Hif1α-target, and its receptor, pdgfrb, were significantly upregulated in response to metabolic stimulation...
  21. Terlizzi V, Kolibabka M, Burgess J, Hammes H, Harmsen M. The Pericytic Phenotype of Adipose Tissue-Derived Stromal Cells Is Promoted by NOTCH2. Stem Cells. 2017;: pubmed publisher
    ..In contrast, ongoing in vivo angiogenesis is influenced by paracrine signaling of ASC, irrespective of Notch signaling. Stem Cells 2017...
  22. Sun C, Zhao Y, Shi J, Zhang J, Yuan Y, Gu Y, et al. Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours. J Neurooncol. 2019;: pubmed publisher
    ..The transcriptions of the angiogenesis-related genes were assessed in TCGA datasets, including ANGPT1, PDGFB and VEGFA...
  23. Stacchiotti S, Pedeutour F, Negri T, Conca E, Marrari A, Palassini E, et al. Dermatofibrosarcoma protuberans-derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib. Int J Cancer. 2011;129:1761-72 pubmed publisher
    Dermatofibrosarcoma Protuberans (DFSP) carries a translocation resulting in the COL1A1/PDGFB fusion-gene, responsible for platelet derived growth factor beta receptor (PDGFRB) activation...
  24. Yin L, He J, Xue J, Na F, Tong R, Wang J, et al. PDGFR-β inhibitor slows tumor growth but increases metastasis in combined radiotherapy and Endostar therapy. Biomed Pharmacother. 2018;99:615-621 pubmed publisher
    ..Tumor growth can be further suppressed by pericyte inhibitor; however, metastases are potentially enhanced. More in-depth studies are warranted to confirm the potential benefits and risks of anti-pericyte therapy. ..
  25. Huang Y, Zhang L, Li M, Cheng L, Zou G, Zhou H. A splice site mutation causing exon 6 skipping in SLC20A2 gene in a primary familial brain calcification family. Brain Res Bull. 2019;: pubmed publisher
    ..Previous studies reported that SLC20A2, PDGFRB, PDGFB, XPR1 and MYORG are associated with PFBC, with SLC20A2 the main culprit...
  26. Munday J, Thomson N, Dunowska M, Knight C, Laurie R, Hills S. Genomic characterisation of the feline sarcoid-associated papillomavirus and proposed classification as Bos taurus papillomavirus type 14. Vet Microbiol. 2015;177:289-95 pubmed publisher
    ..Interestingly BPV-14 has not been detected in any equine sarcoid suggesting that BPV-14 has a host range that is limited to bovids and felids. ..
  27. Kesserwan C, Sokolic R, Cowen E, Garabedian E, Heselmeyer Haddad K, Lee C, et al. Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiency. J Allergy Clin Immunol. 2012;129:762-769.e1 pubmed publisher
    ..chromosomal translocation (t[17;22][q22;q13]) resulting in the COL1A1-platelet-derived growth factor β(PDGFB) fusion gene. This malignancy is rarely diagnosed in childhood...
  28. Fjaer R, Brodtkorb E, Øye A, Sheng Y, Vigeland M, Kvistad K, et al. Generalized epilepsy in a family with basal ganglia calcifications and mutations in SLC20A2 and CHRNB2. Eur J Med Genet. 2015;58:624-8 pubmed publisher
    ..PFBC) has increased considerably in recent years due to the finding of causal genes like SLC20A2, PDGFRB and PDGFB. The phenotype of PFBC is complex and has as of yet been poorly delineated...
  29. Ionescu C, Berindan Neagoe I, Burz C, Balacescu O, Balacescu L, Tudoran O, et al. The clinical implications of platelet derived growth factor B, vascular endothelial growth factor and basic fibroblast growth factor in colorectal cancer. J BUON. 2011;16:274-6 pubmed
    ..by qRT-PCR the level of expression of 3 growth factors involved in angiogenesis: platelet derived growth factor-B (PDGFb), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in patients with different ..
  30. Krzystek Korpacka M, Diakowska D, Gamian A, Matusiewicz M. Increase in serum platelet-derived growth factor (PDGF)-BB reflects lymph node involvement in esophageal cancer patients independently from platelet count. Exp Oncol. 2011;33:140-4 pubmed
  31. Denard P, Lädermann A, Brady P, Narbona P, Adams C, Arrigoni P, et al. Pseudoparalysis From a Massive Rotator Cuff Tear Is Reliably Reversed With an Arthroscopic Rotator Cuff Repair in Patients Without Preoperative Glenohumeral Arthritis. Am J Sports Med. 2015;43:2373-8 pubmed publisher
    ..Shoulder and Elbow Surgeons (ASES) Shoulder Score, visual analog scale (VAS), and subjective shoulder value (SSV). Of the 58 patients enrolled, 56 had at least 1 year of follow-up...
  32. Bacaër N. Le modèle stochastique SIS pour une épidémie dans un environnement aléatoire. J Math Biol. 2016;73:847-66 pubmed publisher
    The stochastic SIS epidemic model in a random environment...
  33. Huang L, Van Schooneveld T, Huang R, Olsen K, Rupp M, Gross A. Guideline-Concordant Versus Discordant Antimicrobial Therapy in Patients With Community-Onset Complicated Intra-abdominal Infections. Infect Control Hosp Epidemiol. 2016;37:855-8 pubmed publisher
    Overall IDSA/SIS intra-abdominal infection guideline compliance was not associated with improved outcomes; however, there was a longer time to active therapy (P=.024) and higher mortality (P=...
  34. Mazzolini G, Sowa J, Canbay A. Cell death mechanisms in human chronic liver diseases: a far cry from clinical applicability. Clin Sci (Lond). 2016;130:2121-2138 pubmed
    ..are limited to surrogate markers for apoptosis (M30), and possibly for pyroptosis (IL-1 family) and necro(pto)sis (HMGB1)...
  35. Lopez J, Sarkanen J, Huttala O, Kaartinen I, Kuokkanen H, Ylikomi T. Adipose tissue extract shows potential for wound healing: in vitro proliferation and migration of cell types contributing to wound healing in the presence of adipose tissue preparation and platelet rich plasma. Cytotechnology. 2018;70:1193-1204 pubmed publisher
    ..Adipose tissue preparation appears to offer the distinct advantage of containing the adequate quantities of growth factors that induce cell activation, proliferation and migration, particularly in the early phase of wound healing. ..
  36. Weich H, Sebald W, Schairer H, Hoppe J. The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain. FEBS Lett. 1986;198:344-8 pubmed
    ..clone of about 2500 base pairs was prepared from the human osteosarcoma cell line U-2 OS by hybridizing with a v-sis probe. Sequence analysis showed that this cDNA contains the coding region for the PDGF-B chain...
  37. Göhring W, Sasaki T, Heldin C, Timpl R. Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope. Eur J Biochem. 1998;255:60-6 pubmed
    ..Neither nidogen, BM-40 or perlecan domain III-2 interfered with the binding of PDGF to its alpha and beta receptors, however, suggesting that these interactions may be mainly used for storage of PDGF in the extracellular matrix. ..
  38. Ren X, Yu X, Gao B, Li J, Liu P. The immune responses and antioxidant status of Portunus trituberculatus individuals with different body weights. Fish Shellfish Immunol. 2016;51:337-345 pubmed publisher
    ..and phenoloxidase activities, of the big individuals (BIs) were higher than those of the small individuals (SIs) (P < 0.05)...
  39. Tutolo M, de Ridder D, Montorsi F, Castagna G, Deprest J, Schellart R, et al. A minimum of 1-year follow-up for MiniArc single incision slings compared to Monarc transobturator slings: An analysis to evaluate durability of continence and medium-term outcomes. Neurourol Urodyn. 2017;36:803-807 pubmed publisher
    To compare efficacy and safety of two commercially available single incision slings (SIS) and trans-obturator vaginal tapes (TOT), namely MiniArcâ„¢ and Monarcâ„¢ slings, and report the results at 5-year follow-up...
  40. Andreini D, Pontone G, Mushtaq S, Gransar H, Conte E, Bartorelli A, et al. Long-term prognostic impact of CT-Leaman score in patients with non-obstructive CAD: Results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) study. Int J Cardiol. 2017;231:18-25 pubmed publisher
    ..Segment-involvement score (SIS) and CT-LeSc were calculated...
  41. Malden L, Chait A, Raines E, Ross R. The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages. J Biol Chem. 1991;266:13901-7 pubmed
    ..This modulation may influence chemotaxis and mitogenesis of smooth muscle cells locally in the artery wall during atherogenesis. ..
  42. Lackerbauer C, Grueterich M, Kojetinsky C, Ulbig M, Kollias A. Customizing the Amadeus II microkeratome: evaluation of cut quality with various settings using electron microscopy. Eur J Ophthalmol. 2009;19:743-7 pubmed
    To evaluate the cut quality of keratectomy specimens created with the new Amadeus II microkeratome (SIS, Ziemer Ophthalmic, Port, Switzerland) using scanning electron microscopy (SEM). Methods...
  43. Asellus P, Nordström P, Nordström A, Jokinen J. CSF Apolipoprotein E in attempted suicide. J Affect Disord. 2018;225:246-249 pubmed publisher
    ..suicide attempts and the reversibility of suicide attempt method were assessed with the Suicide Intent Scale (SIS) and the Freeman Scale. Suicide attempts were classified according to violence of method...
  44. Fischer W, Schubert D. Characterization of a novel platelet-derived growth factor-associated protein. J Neurochem. 1996;66:2213-6 pubmed
    ..PAP binds to PDGF with low affinity and enhances the mitogenic effect of PDGF-A but lowers the mitogenic activity of PDGF-B. PAP mRNA is abundant in the brain of newborn rats and is found in several other tissues. ..
  45. Zhang Y, Zhao Y, Li L, Shen Y, Cai X, Zhang X, et al. The oncoprotein HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote the proliferation of breast cancer cells. Biochem Biophys Res Commun. 2013;434:305-10 pubmed publisher
    ..As an oncogene, the platelet-derived growth factor beta polypeptide (PDGFB) plays crucial roles in carcinogenesis...
  46. Texl J, Huser M, Belkov I, Juráková M, Hudeček R, Janků P, et al. [Efficacy of surgical treatment of stress urinary incontinence with mini-invasive single incision sling]. Ceska Gynekol. 2015;80:345-50 pubmed
    ..All patients included in the study received single incision sling (SIS) Ophira (Promedon). The length of the surgery and blood loss and complication was observed...
  47. Eun K, Jeon H, Kim S, Choi S, Lee S, Jin X, et al. A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells. Biochem Biophys Res Commun. 2017;486:564-570 pubmed publisher
    ..ID4 expression significantly increased PDGF subunit B expression in both in vitro cultures and in vivo tumor xenografts and regulated NO synthase 2 (NOS2) ..
  48. Ji Q, Ma Z, Deng X. Volunteer study and serum protein profiling to understand inflammatory response induced by Satsuma mandarin. Food Res Int. 2015;75:367-373 pubmed publisher
    ..We define the adverse reaction to Satsuma as Satsuma-induced syndrome (SIS). Volunteers were assigned to oral Satsuma challenge in an open manner...
  49. Patel M, Velagapudi C, Burns H, Doss R, Lee M, Mariappan M, et al. Mouse Metanephric Mesenchymal Cell-Derived Angioblasts Undergo Vasculogenesis in Three-Dimensional Culture. Am J Pathol. 2018;188:768-784 pubmed publisher
    ..Thus, MM cells resemble early renal angioblasts that may provide an ideal platform for the investigation of renal vasculogenesis in vitro. ..
  50. Heldin C, Ostman A, Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta. 1998;1378:F79-113 pubmed
    ..Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel. ..
  51. Kovacevic D, Gulotta L, Ying L, Ehteshami J, Deng X, Rodeo S. rhPDGF-BB promotes early healing in a rat rotator cuff repair model. Clin Orthop Relat Res. 2015;473:1644-54 pubmed publisher
    ..Augmenting the healing environment to improve the structural integrity and to reduce the retear rate after rotator cuff repair may be realized with continued understanding and optimization of growth factor delivery systems. ..
  52. Sysol J, Natarajan V, Machado R. PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation. Am J Physiol Cell Physiol. 2016;310:C983-92 pubmed publisher
    ..This novel mechanism of SphK1 regulation may be a therapeutic target in pulmonary vascular remodeling in PAH. ..
  53. Skordos D, Papafragou A. Children's derivation of scalar implicatures: Alternatives and relevance. Cognition. 2016;153:6-18 pubmed publisher
    ..Preschoolers typically fail to spontaneously generate SIs without the assistance of training or context that make the stronger alternative salient...
  54. Bienaime F, Muorah M, Yammine L, Burtin M, Nguyen C, Baron W, et al. Stat3 Controls Tubulointerstitial Communication during CKD. J Am Soc Nephrol. 2016;27:3690-3705 pubmed
    ..Stat3 activation triggered the expression of a specific subset of paracrine profibrotic factors, including Lcn2, Pdgfb, and Timp1...
  55. Le Croizier G, Schaal G, Gallon R, Fall M, Le Grand F, Munaron J, et al. Trophic ecology influence on metal bioaccumulation in marine fish: Inference from stable isotope and fatty acid analyses. Sci Total Environ. 2016;573:83-95 pubmed publisher
    ..This study confirmed the influence of diet in the metal accumulation of marine fish communities, and proved that FAs are very useful and complementary tools to SIs to link metal accumulation in fish with their trophic ecology.
  56. Iannacone M, Beets I, Lopes L, Churgin M, Fang Yen C, Nelson M, et al. The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans. elife. 2017;6: pubmed publisher
    ..In Caenorhabditis elegans, stress-induced sleep(SIS) is regulated by cytokine activation of the ALA neuron, which releases FLP-13 neuropeptides characterized by an ..
  57. Govindarajan B, Shah A, Cohen C, Arnold R, Schechner J, Chung J, et al. Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem. 2005;280:13936-43 pubmed
    ..Our model allows the assessment of epigenetic changes that occur during human carcinogenesis. In addition, these studies provide insight into the clinical failure of tyrosine kinase inhibitors as monotherapy for advanced malignancy. ..
  58. Chua J, Culpan J, Menon E. Efficacy of an Electromechanical Gait Trainer Poststroke in Singapore: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2016;97:683-90 pubmed publisher
    ..Secondary outcomes were the Barthel Index (BI), gait speed and endurance, and Stroke Impact Scale (SIS). Measures were taken at baseline and 4, 8, 12, 24, and 48 weeks...
  59. He S, Guo J, Wang Z, Zhang Y, Tu Y, Wu S, et al. Efficacy and safety of small intestinal submucosa in dural defect repair in a canine model. Mater Sci Eng C Mater Biol Appl. 2017;73:267-274 pubmed publisher
    ..The small intestinal submucosa (SIS) is a promising material used in a variety of applications...
  60. Hann C, Kraus N, Minkus M, Maziak N, Scheibel M. Combined arthroscopically assisted coraco- and acromioclavicular stabilization of acute high-grade acromioclavicular joint separations. Knee Surg Sports Traumatol Arthrosc. 2018;26:212-220 pubmed publisher
    ..At the final follow-up, the constant score (CS), the subjective shoulder value (SSV), the Taft score (TF) and the acromioclavicular joint instability score (ACJI) as well as bilateral anteroposterior ..
  61. Muro Báez V, Mendoza García M, Vera López J, Pérez Núñez R. [Analysis of road traffic injuries in Mexican cyclists]. Gac Med Mex. 2017;153:653-661 pubmed publisher
    ..national level: mortality, Ministry of Health's hospital discharges, Unintentional and Violence Registry System (SIS-SS-17-P) and the 2012 National Health and Nutrition Survey (ENSANUT)...
  62. Mathew B, Léon J, Sannemann W, Sillanpää M. Detection of Epistasis for Flowering Time Using Bayesian Multilocus Estimation in a Barley MAGIC Population. Genetics. 2018;208:525-536 pubmed publisher
    ..In this study, we successfully apply Sure Independence Screening (SIS) for dimensionality reduction to identify two-way and three-way epistasis for the FT trait in a Multiparent ..
  63. Ehrlich H, Freedman B. Topical platelet-derived growth factor in patients enhances wound closure in the absence of wound contraction. Cytokines Cell Mol Ther. 2002;7:85-90 pubmed
    ..Topical PDGF limits the role of wound contraction in wound closure. Control wounds healed by wound contraction, while PDGF-treated wounds close by re-epithelialization and filling in with scar. ..
  64. Allen C, Bayraktutan U. Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells. J Mol Cell Cardiol. 2008;45:198-208 pubmed publisher
  65. Ostrowski K, Dugi D, Hedges J, Barry J. Bone Saw for Calcified Peyronie's Disease Plaques. Urology. 2015;86:415-6 pubmed publisher
    ..Four of those 6 underwent grafting procedures with porcine submucosal intestinal substance (SIS) and 2 underwent placement of inflatable penile prosthesis (IPP) after plaque incision...
  66. Delavaran H, Aked J, Sjunnesson H, Lindvall O, Norrving B, Kokaia Z, et al. Spontaneous Recovery of Upper Extremity Motor Impairment After Ischemic Stroke: Implications for Stem Cell-Based Therapeutic Approaches. Transl Stroke Res. 2017;8:351-361 pubmed publisher
    ..NIHSS, Fugl-Meyer assessment of upper extremity (FMA-UE), modified Rankin Scale (mRS), and Stroke Impact Scale (SIS). UEMI was defined as NIHSS arm/hand score ≥1...
  67. Nedeau A, Bauer R, Gallagher K, Chen H, Liu Z, Velazquez O. A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2008;314:2176-86 pubmed publisher
    ..Our results reveal that PDGF-B-aFBs play a key role in the recruitment/migration and differentiation of MSCs and implicate a bFGF- and CXCL5-dependent mechanism in mediating these effects. ..
  68. Hindi N, Casali P, Morosi C, Messina A, Palassini E, Pilotti S, et al. Imatinib in advanced chordoma: A retrospective case series analysis. Eur J Cancer. 2015;51:2609-14 pubmed publisher
    ..We now report on a retrospective series of PDGFB/PDGFRB positive advanced chordoma patients treated with imatinib as a single agent within a compassionate-use ..
  69. Banerjee S, Sengupta K, Dhar K, Mehta S, D Amore P, Dhar G, et al. Breast cancer cells secreted platelet-derived growth factor-induced motility of vascular smooth muscle cells is mediated through neuropilin-1. Mol Carcinog. 2006;45:871-80 pubmed
    ..Moreover, we demonstrate that PDGF physically interacts with NRP-1. We propose that tumor-derived PDGF and NRP-1 of AOSMCs function as a relay system that promotes motility of vascular SMCs. ..
  70. Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell. 2007;131:463-75 pubmed
    ..The efficacy and safety of alphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment. ..
  71. Katzan I, Thompson N, Lapin B, Uchino K. Added Value of Patient-Reported Outcome Measures in Stroke Clinical Practice. J Am Heart Assoc. 2017;6: pubmed publisher
    ..from September 14, 2012 to June 16, 2015 who completed the routinely collected PROMs: Stroke Impact Scale-16 (SIS-16), EQ-5D, Patient Health Questionnaire-9, PROMIS Physical Function, and PROMIS fatigue...
  72. Bartlett C, Scott R, Carota I, Wnuk M, Kanwar Y, Miner J, et al. Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1. Am J Physiol Renal Physiol. 2017;313:F1232-F1242 pubmed publisher
    ..In vitro data show that the potent chemotactic effect of PDGFB is lost in Nrp1-deficient mesangial cells...
  73. Ceulemans A, Verhulst S, Van Haele M, Govaere O, Ventura J, van Grunsven L, et al. RNA-sequencing-based comparative analysis of human hepatic progenitor cells and their niche from alcoholic steatohepatitis livers. Cell Death Dis. 2017;8:e3164 pubmed publisher
    ..Integration of the HPC niche profile suggests autocrine signalling by HPCs (TNFα, PDGFB and VEGFA) as well as paracrine signalling from the surrounding niche cells including MIF and IGF-1...
  74. Andersson M, Ostman A, Backstrom G, Hellman U, George Nascimento C, Westermark B, et al. Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. J Biol Chem. 1992;267:11260-6 pubmed
    ..Thus, structural information has been obtained that will allow the large scale production of properly folded monomeric PDGF, as well as design of specific PDGF heterodimers. ..
  75. Gonias S, Carmichael A, Mettenburg J, Roadcap D, Irvin W, Webb D. Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta. J Biol Chem. 2000;275:5826-31 pubmed
    ..Thus, FP3 may inhibit the activity of PDGF-BB. ..
  76. Kamp H, Geilen C, Sommer C, Blume Peytavi U. Regulation of PDGF and PDGF receptor in cultured dermal papilla cells and follicular keratinocytes of the human hair follicle. Exp Dermatol. 2003;12:662-72 pubmed
    ..The question concerning the latter hypothesis remains to be elucidated in further studies on whole organ cultures. ..
  77. Theisen C, Wahl J, Johnson K, Wheelock M. NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motility. Mol Biol Cell. 2007;18:1220-32 pubmed
    ..These studies implicate N-cadherin and beta-catenin in cell migration via PDGF-R-mediated signaling through the scaffolding molecule NHERF. ..
  78. Li L, Asteriou T, Bernert B, Heldin C, Heldin P. Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem J. 2007;404:327-36 pubmed
    ..We conclude that the ERK MAPK and PI3K signalling pathways are necessary for the regulation of hyaluronan synthesis by PDGF-BB, and that prevention of its binding to CD44 inhibits PDGF-BB-induced cell growth. ..
  79. Reinmuth N, Rensinghoff S, Raedel M, Fehrmann N, Schwöppe C, Kessler T, et al. Paracrine interactions of vascular endothelial growth factor and platelet-derived growth factor in endothelial and lung cancer cells. Int J Oncol. 2007;31:621-6 pubmed
    ..g. by the reciprocal induction of VEGF and PDGF-BB. Thus, targeting key molecules would result in expression alterations of multiple factors and alter the biological functions of both stromal and tumor cells. ..
  80. Westenberger A, Klein C. The genetics of primary familial brain calcifications. Curr Neurol Neurosci Rep. 2014;14:490 pubmed publisher
    ..In the past 2 years, 3 genes have been identified to cause PFBC, (ie, SLC20A2, PDGFRB, and PDGFB)...
  81. Vanlandewijck M, Lebouvier T, Andaloussi Mäe M, Nahar K, Hornemann S, Kenkel D, et al. Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification. PLoS ONE. 2015;10:e0143407 pubmed publisher
    ..characterized by progressive pericapillary calcifications, has recently been linked to heterozygous mutations in PDGFB and PDGFRB genes. Here, we functionally analyzed several of these mutations in vitro...
  82. Liu Y, Ma W, Liu B, Wang Y, Chu J, Xiong G, et al. Urethral reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model. Stem Cell Res Ther. 2017;8:63 pubmed publisher
    ..the feasibility of using autologous urine-derived stem cells (USCs) seeded on small intestinal submucosa (SIS) to repair a urethral defect in a rabbit model...
  83. Lesage F, Pranpanus S, Bosisio F, Jacobs M, Ospitalieri S, Toelen J, et al. Minimal modulation of the host immune response to SIS matrix implants by mesenchymal stem cells from the amniotic fluid. Hernia. 2017;21:973-982 pubmed publisher
    ..We implant cell free small intestinal submucosa (SIS) or SIS seeded with AF-MSC at a density of 1 × 105/cm2 subcutaneously at the abdominal ..
  84. Bastos A, Blunck C, Emerenciano M, Gimba E. Osteopontin and their roles in hematological malignancies: Splice variants on the new avenues. Cancer Lett. 2017;408:138-143 pubmed publisher
    ..This review aims to summarize tOPN roles in HMs and provide evidence that OPN-SIs can also modulate specific functions in HMs biology...
    ..structural characteristics of intraocular lenses (IOLs) implanted with transconjunctival sutureless intrascleral (SIS) fixation in human eyes. Retrospective interventional surgical case series involving live and cadaveric human eyes...
  86. Kaminski W, Lindahl P, Lin N, Broudy V, Crosby J, Hellstrom M, et al. Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice. Blood. 2001;97:1990-8 pubmed
    ..The chimera models in this study will serve as valuable tools to test the role of PDGF in inflammatory and immune responses. (Blood. 2001;97:1990-1998) ..
  87. Sun J, Wang D, Jain R, Carie A, Paquette S, Ennis E, et al. Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene. 2005;24:4701-9 pubmed
    ..Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis. Thus, inhibition of VEGF and PDGF receptor binding with a synthetic molecule results in potent inhibition of angiogenesis and tumorigenesis. ..
  88. Bezuidenhout L, Bracher M, Davison G, Zilla P, Davies N. Ang-2 and PDGF-BB cooperatively stimulate human peripheral blood monocyte fibrinolysis. J Leukoc Biol. 2007;81:1496-503 pubmed
    ..These data give further credence to the concept of Ang-2 as a key regulator of several essential phases of wound healing. ..
  89. Rong Z, Wang C, Hao J, Duan H. [Expression and clinical implication of platelet-derived growth factor-D and platelet-derived growth factor-beta in childhood IgA nephropathy]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008;20:275-8 pubmed
    ..PDGF-D might significantly enhance the development of mesangial proliferation and tubulointerstitial fibrosis. In comparison with PDGF-B, PDGF-D appears to reflect more sensitive to the severity and prognosis of IgA nephropathy. ..
  90. Widder A, Kuehn C. Heterogeneous population dynamics and scaling laws near epidemic outbreaks. Math Biosci Eng. 2016;13:1093-1118 pubmed publisher
    ..and stochasticity of the population on the dynamical structure of a basic susceptible-infected-susceptible (SIS) model...
  91. Dénes A, Muroya Y, Rost G. Global stability of a multistrain SIS model with superinfection. Math Biosci Eng. 2017;14:421-435 pubmed publisher
    In this paper, we study the global stability of a multistrain SIS model with superinfection...
  92. Kim M, Sohn M, Shim M, Choi S, Park M, Kim E, et al. Prognostic value of vascular endothelial growth factor (VEGF), VEGF receptor 2, platelet-derived growth factor-? (PDGF-?), and PDGF-? receptor expression in papillary renal cell carcinoma. Hum Pathol. 2017;61:78-89 pubmed publisher
    ..3%; progressive disease, 41.7%; P=.052). pRCC with high VEGFR2 expression seems to be associated with a better initial response to targeted drug therapy and a better prognostic outcome. ..