PDE4D

Summary

Gene Symbol: PDE4D
Description: phosphodiesterase 4D, cAMP-specific
Alias: ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific phosphodiesterase PDE4D6, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Species: human

Top Publications

  1. ncbi Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization
    Xavier Miro
    Department of Molecular Genetics, Instituto de Biologia Molecular de Barcelona, CID CSIC, E 08034 Barcelona, Spain
    Synapse 45:259-69. 2002
  2. ncbi Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle
    Jy Young Park
    Division of Reproductive Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5317, USA
    Mol Endocrinol 17:1117-30. 2003
  3. ncbi RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells
    Martin J Lynch
    Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, Wolfson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 280:33178-89. 2005
  4. ncbi Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays
    Derek J Nancarrow
    Oncogenomics, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Res 68:4163-72. 2008
  5. ncbi Association between the PDE4D gene and ischaemic stroke in the Chinese Han population
    Yun Sun
    Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China
    Clin Sci (Lond) 117:265-72. 2009
  6. ncbi beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi
    George S Baillie
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute for Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Proc Natl Acad Sci U S A 100:940-5. 2003
  7. ncbi mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
    K L Dodge
    Howard Hughes Medical Institute and Vollum Institute, and Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    EMBO J 20:1921-30. 2001
  8. ncbi The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains
    M B Beard
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, University of Glasgow, UK
    FEBS Lett 460:173-7. 1999
  9. ncbi A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells
    Charlotte K Billington
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Am J Respir Cell Mol Biol 38:1-7. 2008
  10. ncbi Association of phosphodiesterase 4D gene polymorphisms with chronic obstructive pulmonary disease: relationship to interleukin 13 gene polymorphism
    Shinsuke Homma
    Department of Pulmonary Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Int J Mol Med 18:933-9. 2006

Research Grants

  1. CRYSTAL STRUCT. OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE
    Hengming Ke; Fiscal Year: 2003
  2. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2006
  3. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2007
  4. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2009
  5. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark J Fisher; Fiscal Year: 2010
  6. Hormonal Regulation of Phosphodiestrases
    Marco Conti; Fiscal Year: 2010
  7. Canthinones as Human Isozyme Selective PDE4 Inhibitors
    KEVIN CZERWINSKI; Fiscal Year: 2002
  8. NEUROPSYCHOPHARMACOLOGY OF CYCLIC AMP PDE INHIBITORS
    JAMES O DONNELL; Fiscal Year: 2002
  9. NEUROPSYCHOPHARMACOLOGY OF CYCLIC AMP PDE INHIBITORS
    JAMES O DONNELL; Fiscal Year: 2007
  10. Spatiotemporal regulation of beta adrenoceptor signaling in cardiacmyocytes
    Yang K Xiang; Fiscal Year: 2011

Detail Information

Publications149 found, 100 shown here

  1. ncbi Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization
    Xavier Miro
    Department of Molecular Genetics, Instituto de Biologia Molecular de Barcelona, CID CSIC, E 08034 Barcelona, Spain
    Synapse 45:259-69. 2002
    ..Members of the PDE4 enzyme family are selectively inhibited by rolipram. Five different mRNA splice forms for PDE4D have been isolated...
  2. ncbi Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle
    Jy Young Park
    Division of Reproductive Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5317, USA
    Mol Endocrinol 17:1117-30. 2003
    ..Here, we provide evidence that one of these feedback regulations involving the cyclic nucleotide phosphodiesterase PDE4D plays a critical role in cAMP signaling during the differentiation of granulosa cells of the ovarian follicle...
  3. ncbi RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells
    Martin J Lynch
    Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, Wolfson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 280:33178-89. 2005
    PDE4B and PDE4D provide >90% of PDE4 cAMP phosphodiesterase activity in human embryonic kidney (HEK293B2) cells...
  4. ncbi Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays
    Derek J Nancarrow
    Oncogenomics, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Res 68:4163-72. 2008
    ..were also noted for known tumor suppressor genes (TSG), including CDKN2A, CDKN2B, SMAD4, and GALR1, and identified PDE4D and MGC48628 as potentially novel TSGs...
  5. ncbi Association between the PDE4D gene and ischaemic stroke in the Chinese Han population
    Yun Sun
    Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China
    Clin Sci (Lond) 117:265-72. 2009
    Recent findings suggests that PDE4D (gene encoding phosphodiesterase 4D) is a stroke-related gene in the Icelandic population, but it is still very controversial as to whether it is a susceptible gene for stroke in other populations...
  6. ncbi beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi
    George S Baillie
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute for Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Proc Natl Acad Sci U S A 100:940-5. 2003
    ..are treated with the selective PDE4-inhibitor rolipram or when they are transfected with a catalytically inactive PDE4D mutant (PDE4D5-D556A) that competitively inhibits isoprenaline-stimulated recruitment of native PDE4 to the beta(2)..
  7. ncbi mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
    K L Dodge
    Howard Hughes Medical Institute and Vollum Institute, and Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    EMBO J 20:1921-30. 2001
    ..Disruption of PKA- mAKAP interaction prevents this enhancement of PDE4D3 activity, suggesting that the proximity of both enzymes in the mAKAP signaling complex forms a negative feedback loop to restore basal cAMP levels...
  8. ncbi The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains
    M B Beard
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, University of Glasgow, UK
    FEBS Lett 460:173-7. 1999
    Of the five PDE4D isoenzymes, only the PDE4D4 cAMP specific phosphodiesterase was able to bind to SH3 domains...
  9. ncbi A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells
    Charlotte K Billington
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Am J Respir Cell Mol Biol 38:1-7. 2008
    ..previously reported that PDE4 family members are likely to be important in this process, and that expression of PDE4D variants is actively regulated at the transcriptional level...
  10. ncbi Association of phosphodiesterase 4D gene polymorphisms with chronic obstructive pulmonary disease: relationship to interleukin 13 gene polymorphism
    Shinsuke Homma
    Department of Pulmonary Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Int J Mol Med 18:933-9. 2006
    ..We hypothesized that polymorphisms of the phosphodiesterase 4D (PDE4D) gene activate its protein function which leads to the downregulation of cAMP, resulting in the development of ..
  11. ncbi Stroke genetics--focus on PDE4D gene
    Anjana Munshi
    Department of Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad, India
    Int J Stroke 3:188-92. 2008
    ..Recently, the deCODE group has suggested an association between the phosphodiesterase 4D (PDE4D) gene and the risk of stroke in Icelanders...
  12. ncbi Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls
    Steve Bevan
    Centre for Clinical Neuroscience, St George s, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1966-71. 2008
    b>PDE4D was identified as the first novel gene associated with ischemic stroke risk. Replication studies have produced conflicting results, but many have been small and underpowered...
  13. ncbi Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion
    Daniel R Raymond
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada K7L 3N6
    Cell Signal 19:2507-18. 2007
    ..PKA- or EPAC-containing complexes can contain either phosphodiesterase 3B, [PDE3B] or phosphodiesterase 4D [PDE4D], they do not contain both these phosphodiesterases...
  14. ncbi Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity
    Qing Huai
    Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC 27599 7260, USA
    J Biol Chem 279:13095-101. 2004
    ..IBMX binds to a subpocket that comprises key residues Ile-336, Phe-340, Gln-369, and Phe-372 of PDE4D2 or Val-782, Phe-786, Gln-817, and Phe-820 of PDE5A1. This subpocket may be a common site for binding nonselective inhibitors of PDEs...
  15. ncbi Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter
    Ivan R Le Jeune
    Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 277:35980-9. 2002
    Phosphodiesterase 4D (PDE4D), part of the complex cAMP-specific PDE4 family, plays a pivotal role in the regulation of airway smooth muscle relaxation by catalyzing the hydolysis of cAMP...
  16. ncbi Lack of association between variations of PDE4D and ischemic stroke in the Japanese population
    Tomonaga Matsushita
    Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
    Stroke 40:1245-51. 2009
    After the first genomewide association study of ischemic stroke identified PDE4D as a susceptible gene, many replication studies have been conducted...
  17. ncbi An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
    Debbie Willoughby
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    EMBO J 25:2051-61. 2006
    ..Co-immunoprecipitation confirmed that gravin maintains a signaling complex that includes PKA and PDE4D. We propose that gravin-associated PDE4D isoforms provide a means to rapidly terminate subplasmalemmal cAMP ..
  18. ncbi cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model
    R Hoffmann
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Davidson and Wolfson Buildings, IBLS, University of Glasgow, Glasgow G12 8QQ, Scotland, U K
    Biochem J 333:139-49. 1998
    ..The increase in susceptibility to inhibition by rolipram upon PKA-mediated phosphorylation is suggested to involve the disruption of a hydrogen-bond involving the side-chain hydroxy group of Ser-54...
  19. ncbi Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
    Qing Huai
    Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA
    Structure 11:865-73. 2003
    ..Docking of the PDE5 inhibitor sildenafil into the PDE4 catalytic pocket further helps understand inhibitor selectivity...
  20. ncbi Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study
    Qing Song
    Morehouse School of Medicine, Atlanta, GA 30314, USA
    Hum Mol Genet 15:2468-78. 2006
    An association between polymorphisms within the phosphodiesterase 4D gene (PDE4D) and ischemic stroke was initially reported in older adults from Iceland and has been supported by studies in several other primarily elderly populations...
  21. ncbi Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population
    Sofie Nilsson-Ardnor
    Department of Medical Biosciences, Umea University, SE 901 87, Umea, Sweden
    Stroke 36:1666-71. 2005
    ..demonstrated linkage for common forms of stroke to chromosome 5q12 and association between phosphodiesterase4D (PDE4D) and ischemic stroke...
  22. ncbi Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins
    Stephen J Perry
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 298:834-6. 2002
    ....
  23. ncbi Association of PDE4D and IL-1 gene polymorphism with ischemic stroke in a Han Chinese population
    Nan Li
    Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Brain Res Bull 81:38-42. 2010
    The single-nucleotide polymorphisms (SNPs) of the phosphodiesterase 4D (PDE4D) and interleukin-1 (IL-1) genes are associated with increased risk for the development of ischemic stroke (IS) in whites...
  24. ncbi Many hypotheses but no replication for the association between PDE4D and stroke
    Jonathan Rosand
    Nat Genet 38:1091-2; author reply 1092-3. 2006
  25. ncbi Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 58:351-61. 2005
    ..Iceland identified risk polymorphisms in two putative candidate genes for ischemic stroke: phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP)...
  26. ncbi The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins
    Graeme B Bolger
    University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham, Alabama 35294 3300, USA
    J Biol Chem 278:49230-8. 2003
    Isoproterenol challenge of Hek-B2 cells causes a transient recruitment of the endogenous PDE4D isoforms found in these cells, namely PDE4D3 and PDE4D5, to the membrane fraction...
  27. ncbi Phosphodiesterase 4D gene and risk of noncardiogenic ischemic stroke in a Korean population
    Myeong Kyu Kim
    Department of Neurology, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, Korea
    J Korean Med Sci 24:307-10. 2009
    ..different populations provide apparently conflicting evidence on the association between the phosphodiesterase 4D (PDE4D) gene and ischemic stroke...
  28. ncbi Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population
    M J E van Rijn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Neurology 65:1203-9. 2005
    The purpose of this investigation was to study the familial aggregation of ischemic stroke and the association between the PDE4D gene and ischemic stroke.
  29. ncbi Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population
    Danish Saleheen
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Stroke 36:2275-7. 2005
    Identification of STRK1 locus by the deCODE group followed by the discovery of phosphodiesterase 4D (PDE4D) gene in strong association with ischemic stroke patients has provided useful insights toward understanding the genetic etiology ..
  30. ncbi Genotype and haplotype association study of the STRK1 region on 5q12 among Japanese: a case-control study
    Tomohiro Nakayama
    Division of Receptor Biology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Stroke 37:69-76. 2006
    ..infarction with a significant logarithm of odds score at 5q12 in whites in 2002 and subsequently identified the PDE4D gene as a susceptibility gene at this locus in 2003...
  31. ncbi ALOX5AP gene and the PDE4D gene in a central European population of stroke patients
    Elin Lõhmussaar
    Institutes of Human Genetics, GSF National Research Institute for Environment and Health, Neuherberg, Germany
    Stroke 36:731-6. 2005
    Recent evidence has implicated the genes for 5-lipoxygenase activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) as susceptibility genes for stroke in the Icelandic population...
  32. ncbi Association of Phosphodiesterase 4D with ischemic stroke: a population-based case-control study
    Daniel Woo
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0525, USA
    Stroke 37:371-6. 2006
    The Phosphodiesterase 4D (PDE4D) gene was reported recently to be associated with ischemic stroke in an Icelandic population. The association was found predominately with large vessel and cardioembolic stroke...
  33. ncbi Evaluation of single nucleotide polymorphisms in the phosphodiesterase 4D gene (PDE4D) and their association with ischaemic stroke in a large German cohort
    G Kuhlenbaumer
    Department of Neurology and Leibniz Institute for Atherosclerosis Research, University of Munster, Albert Schweitzer Str 33, 48129, Munster, Germany
    J Neurol Neurosurg Psychiatry 77:521-4. 2006
    ..which has been mapped to chromosome 5q12 in Icelandic families), has identified the phosphodiesterase 4D gene (PDE4D) gene as a good candidate gene...
  34. ncbi Association of phosphodiesterase 4D polymorphisms with ischemic stroke in a US population stratified by hypertension status
    Victoria H Brophy
    Roche Molecular Systems, Alameda, CA 94501, USA
    Stroke 37:1385-90. 2006
    Phosphodiesterase 4D (PDE4D) underlies the STRK1 linkage peak for stroke on chromosome 5q12 identified in Iceland...
  35. ncbi Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis
    S Bevan
    Department of Clinical Neuroscience, St George s Hospital Medical School, Tooting, London, UK
    Stroke 36:949-53. 2005
    Phosphodiesterase 4D (PDE4D) was identified recently as the first novel stroke gene to predispose to ischemic stroke independently of conventional risk factors...
  36. ncbi Polymorphisms of the phosphodiesterase 4D, cAMP-specific (PDE4D) gene and risk of ischemic stroke: a prospective, nested case-control evaluation
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA
    Stroke 37:2012-7. 2006
    In an Icelandic population, gene variants of the phosphodiesterase 4D, cAMP-specific (PDE4D) gene were reported to be risk predictors for ischemic stroke...
  37. ncbi Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
    Graeme B Bolger
    Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Biochem J 398:23-36. 2006
    ..Modelled on the PDE4D catalytic domain, these form distinct well-defined surface-exposed patches on helices-15-16, for RACK1, and helix-..
  38. ncbi Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5
    Graeme B Bolger
    Veterans Affairs Medical Center, Huntsman Cancer Institute, Division of Oncology, Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84148, USA
    BMC Biochem 3:24. 2002
    ..Two-hybrid analysis of truncation and mutant constructs of the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5 were used to define a domain conferring interaction with the signaling scaffold protein, RACK1...
  39. ncbi ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions
    S J Mackenzie
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Davidson Bldg, IBLS, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 275:16609-17. 2000
    ..isoforms, are proposed to amplify the small, inherent inhibitory effect that ERK2 phosphorylation exerts on the PDE4D catalytic unit...
  40. ncbi cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling
    M J Lynch
    Division of Biochemistry and Molecular Biology, IBLS Institute of Biomedical and Life Sciences, Wolfson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U K
    Biochem Soc Trans 35:938-41. 2007
    ....
  41. ncbi Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region
    Håkan Lövkvist
    Department of Clinical Sciences, Lund, Neurology, Lund University Hospital, Lund, Sweden
    Eur J Hum Genet 16:1117-25. 2008
    Previous Icelandic studies reported that single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) region and the 5-lipoxygenase activating protein ALOX5AP were associated with ischaemic stroke, whereas other studies ..
  42. ncbi The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform
    S J Yarwood
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biology and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 274:14909-17. 1999
    ..RACK1 did not interact with other PDE4D isoforms or with known PDE4A, PDE4B, and PDE4C isoforms...
  43. ncbi Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation
    C Sette
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305 5317, USA
    J Biol Chem 271:16526-34. 1996
    ..These findings support the hypothesis that the PDE4D3 variant contains a regulatory domain target for phosphorylation at the amino terminus of the protein and that Ser54 in this domain plays a crucial role in activation...
  44. ncbi 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1
    K John Smith
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, PO Box 363, B15 2TT, UK
    Cell Signal 19:2612-24. 2007
    ....
  45. ncbi Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population
    L Fidani
    Department of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur J Neurol 14:745-9. 2007
    We have examined the association of phosphodiesterase 4D (PDE4D) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818-1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with ..
  46. ncbi A whole genome association study of neuroticism using DNA pooling
    S Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 13:302-12. 2008
    ..We were able to replicate association of one SNP within the PDE4D gene in a second sample collected by our laboratory and in a family-based test in an independent sample; however, ..
  47. ncbi Association between phosphodiesterase 4D gene and ischaemic stroke
    J M Staton
    Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia
    J Neurol Neurosurg Psychiatry 77:1067-9. 2006
    An association between the phosphodiesterase 4D (PDE4D) gene and risk of ischaemic stroke in an Icelandic population has been suggested by the deCODE group.
  48. ncbi PDE4D and ALOX5AP genetic variants and risk for Ischemic Cerebrovascular Disease in Sweden
    Konstantinos Kostulas
    Department of Neurology, Neuro Angiological Research Center, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Huddinge, Sweden
    J Neurol Sci 263:113-7. 2007
    Genetic variants in Phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP) have been shown to confer risk of Ischemic Cerebrovascular Disease (ICVD) in Iceland...
  49. ncbi Localization of a susceptibility gene for common forms of stroke to 5q12
    Solveig Gretarsdottir
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 70:593-603. 2002
    ..This locus on 5q12, which we have designated as "STRK1," does not correspond to known susceptibility loci for stroke or for its risk factors and represents the ..
  50. ncbi A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
    G Bolger
    Cold Spring Harbor Laboratory, New York 11724
    Mol Cell Biol 13:6558-71. 1993
    ..Each of the four genes demonstrated a distinctive pattern of expression in RNA from human cell lines...
  51. ncbi Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene
    G B Bolger
    Department of Veterans Affairs Medical Center, 151M, and Huntsman Cancer Institute, Department of Oncologic Sciences and Department of Medicine Hematology Oncology University of Utah Health Sciences Center, Salt Lake City, UT 84148, USA
    Biochem J 328:539-48. 1997
    We have isolated and characterized complete cDNAs for two isoforms (HSPDE4D4 and HSPDE4A5) encoded by the human PDE4D gene, one of four genes that encode cAMP-specific rolipram-inhibited 3',5'-cyclic nucleotide phosphodiesterases (type ..
  52. ncbi Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium
    Anthony P Barnes
    Department of Cell and Developmental Biology and Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 280:7997-8003. 2005
    ..Using reverse transcription-PCR, Western blotting, and activity measurements, PDE4D was identified as the major PDE species in airway epithelia...
  53. ncbi The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
    Solveig Gretarsdottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 35:131-8. 2003
    ..We found the strongest association in the gene encoding phosphodiesterase 4D (PDE4D), especially for carotid and cardiogenic stroke, the forms of stroke related to atherosclerosis...
  54. ncbi Genetics of common polygenic stroke
    Anna F Dominiczak
    Nat Genet 35:116-7. 2003
  55. ncbi Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5
    M R Steele
    Veterans Affairs Medical Center, Huntsman Cancer Institute, Department of Medicine Division of Oncology and Oncological Science, University of Utah Health Sciences Center, 500 Foothill Drive, Salt Lake City, UT 84148, USA
    Cell Signal 13:507-13. 2001
    ..We propose that this surface of RACK1 is the major site for its interaction with the unique amino-terminal region of PDE4D5...
  56. ncbi PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries
    António José Santos-Silva
    Centro de Investigacao em Ciencias da Saude, Universidade da Beira Interior, Av Infante D Henrique, 6200 506 Covilha, Portugal
    Eur J Pharmacol 582:102-9. 2008
    ..in human umbilical artery smooth muscle was analysed by RT-PCR and the expression of PDE1B, PDE3A, PDE3B, PDE4C, PDE4D and PDE5A was detected...
  57. ncbi Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 3:1176-86. 2010
    ..recurrent small regions of chromosomal loss disrupted single genes, including FHIT, WWOX, RUNX1, KIF26B, MGC48628, PDE4D, C20orf133, GMDS, DMD, and PARK2, most of which are common fragile site regions in the human genome...
  58. ncbi Both protein kinase A and exchange protein activated by cAMP coordinate adhesion of human vascular endothelial cells
    Stuart J Netherton
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada, K7L 3N6
    Circ Res 101:768-76. 2007
    ..complexes in both macro- and micro-VECs and demonstrate that each of these complexes contains either PDE3B or PDE4D but not both of these PDEs...
  59. ncbi Cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase is functional in bovine mammary gland
    V Dostaler-Touchette
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Universite Laval, Quebec, Canada
    J Dairy Sci 92:3757-65. 2009
    ..Reverse transcription PCR revealed that the PDE4D transcript was amplified, and the expected size fragment was obtained in a 1% agarose gel...
  60. ncbi Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease
    M A Giembycz
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Expert Opin Investig Drugs 10:1361-79. 2001
    ..or PDE4, isoenzyme that predominates in pro-inflammatory and immune cells and is ten-fold more selective for PDE4D than for PDE4A, B and C...
  61. ncbi Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells
    S I Takahashi
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599, USA
    Biochim Biophys Acta 1540:68-81. 2001
    ..Under basal conditions, transcripts corresponding to PDE4A, PDE4B, PDE4C, and PDE4D were present...
  62. ncbi Expression of the cAMP-phosphodiesterase PDE4D isoforms and age-related changes in follicle-stimulating hormone-stimulated PDE4 activities in immature rat sertoli cells
    Guénaëlle Levallet
    EA 2608, INRA USC 2006, Laboratoire Oestrogènes et Reproduction, Universite de Caen, 14032 Caen, France
    Biol Reprod 76:794-803. 2007
    ..RT-PCR and immunoblotting experiments showed that almost all the PDE4D isoforms, known as the main cAMP-regulated rolipram-sensitive PDE in Sertoli cells, were expressed throughout the ..
  63. ncbi Phosphodiesterase 4 inhibition synergizes with relaxin signaling to promote decidualization of human endometrial stromal cells
    Olaf Bartsch
    Institute for Hormone and Fertility Research, University of Hamburg, 20251 Hamburg, Germany
    J Clin Endocrinol Metab 89:324-34. 2004
    ..Gene expression for PDE4D and PDE4C was significantly up-regulated during in vitro decidualization...
  64. ncbi Vascular smooth muscle cell phosphodiesterase (PDE) 3 and PDE4 activities and levels are regulated by cyclic AMP in vivo
    Douglas G Tilley
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Mol Pharmacol 62:497-506. 2002
    ..agent induced increase in PDE3 and PDE4, 1) systemic administration of forskolin increased PDE3A, PDE3B, and PDE4D mRNA levels in aortic VSMC and femoral artery VSMC, 2) local delivery of dbcAMP increased PDE3A, PDE3B, and PDE4D3 ..
  65. ncbi Selective activation of rolipram-sensitive, cAMP-specific phosphodiesterase isoforms by phosphatidic acid
    G Nemoz
    Unité 352 Institut National de la Santé de de la Recherche Médicale, Biochimie et Pharmacologie Institut National des Sciences Appliquées Lyon, Villeurbanne, France
    Mol Pharmacol 51:242-9. 1997
    ..activation by using recombinant cAMP-specific PDE4 isoforms derived from three different genes (PDE4A, PDE4B, and PDE4D)...
  66. ncbi Characterization of novel phosphodiesterases in the bovine ovarian follicle
    Maxime Sasseville
    Departement des Sciences Animales, Centre de Recherche en Biologie de la Reproduction, Universite Laval, Sainte Foy, Quebec, Canada
    Biol Reprod 81:415-25. 2009
    ..rodents, the current mammalian model of PDE distribution in the ovarian follicle predicts Pde3a in the oocyte and Pde4d in the somatic cells...
  67. ncbi Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats
    Dongmei Cheng
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    Hypertension 56:1096-101. 2010
    ..both cell types from both rat strains, mRNA levels for the PDE4B subtype exceeded levels for the PDE4A, PDE4C, and PDE4D subtypes, and small interfering RNA knockdown of PDE4B mRNA in SHR smooth muscle cells increased isoproterenol-..
  68. ncbi Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
    Annette Robichaud
    Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Clin Invest 110:1045-52. 2002
    ..The specific roles of PDE4B and PDE4D in this model were studied using mice deficient in either subtype...
  69. ncbi Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect
    J A Cherry
    Department of Psychology, Boston University, Massachusetts 02215, USA
    J Comp Neurol 407:287-301. 1999
    ..specific antibodies were generated against the proteins encoded by each of three dunce homologs PDE4A, PDE4B, and PDE4D in the mouse. On Western blots, these antibodies recognized multiple protein species in all brain regions studied...
  70. ncbi Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain
    S Pérez-Torres
    Department of Neurochemistry, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, C Rosselló 161, 6a, E 08036, Barcelona, Spain
    J Chem Neuroanat 20:349-74. 2000
    ..examined the distribution of four different cyclic AMP-specific phosphodiesterase isozyme (PDE4A, PDE4B, PDE4C and PDE4D) mRNAs in the brain of different species by in situ hybridization histochemistry and by autoradiography with [3H]..
  71. ncbi Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells
    Mikael Ahlstrom
    Department of Applied Chemistry and Microbiology, University of Helsinki, P O Box 66, Helsinki 00014, Finland
    Biochem Pharmacol 69:267-75. 2005
    ..subtypes were detected by reverse transcriptase PCR (RT-PCR): PDE1A, PDE1C, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE10A and PDE11A...
  72. ncbi Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation
    Zhude Tu
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 37:509-16. 2010
    ..inhibitor of phosphodiesterase (PDE) 10A with IC(50) values of 36 nM for PDE10A, 1,300 nM for PDE3A and 320 nM for PDE4D, has served as a useful pharmaceutical tool to study the physiological role of PDE10A...
  73. ncbi The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release
    W K Ong
    Strathclyde Institute of Pharmacy, Cell Biology Group, University of Strathclyde, Glasgow, UK
    Br J Pharmacol 157:633-44. 2009
    ..As cAMP is hydrolysed by cAMP phosphodiesterases (PDEs), we determined the role of PDEs and particularly PDE4 in regulating GLP-1 release...
  74. ncbi Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 27:587-95. 2002
    ..In the present study, immunoblot analysis showed loss of phosphodiesterase 4D (PDE4D) expression in the cerebral cortex and hippocampus of PDE4D knockout (PDE4D-/-) mice, but unchanged PDE4A and ..
  75. ncbi The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D
    F Mori
    Department of Neurochemistry and Neuropharmacology, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, CIBERNED, Rossello 161, 6 a 08036 Barcelona, Spain
    J Chem Neuroanat 40:36-42. 2010
    ..distribution and cellular localization of the four gene transcripts of the PDE4 subfamily (PDE4A, PDE4B, PDE4C and PDE4D) in human brainstem...
  76. ncbi Tilapia hepcidin 2-3 peptide modulates lipopolysaccharide-induced cytokines and inhibits tumor necrosis factor-alpha through cyclooxygenase-2 and phosphodiesterase 4D
    Venugopal Rajanbabu
    Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, 262 Jiaushi, Taiwan
    J Biol Chem 285:30577-86. 2010
    ..In LPS-stimulated cells, TH2-3 acts like melaxicam and down-regulates COX-2 and up-regulates PDE4D. The reduction in intracellular cAMP by TH2-3 or melaxicam in LPS-stimulated cells supports the negative ..
  77. ncbi Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2
    M Sullivan
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, IBLS, Davidson and Wolfson Buildings, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Biochem J 333:693-703. 1998
    ..produce this short PDE4A isoform shown to occur at a different position from that seen in both the rat PDE4B and PDE4D genes...
  78. ncbi Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes
    Xiang Li
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, IBLS, Wolfson Link Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland, UK
    Biochem J 394:427-35. 2006
    ..inactivated, either chemically with rolipram or by siRNA (small interfering RNA)-mediated knockdown of PDE4B and PDE4D. PDE4-selective inhibition by rolipram facilitates the isoprenaline-induced membrane translocation of GRK2, ..
  79. ncbi Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A
    Karnam S Murthy
    Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Gastrointest Liver Physiol 294:G327-35. 2008
    ..by PKA-mediated phosphorylation of cAMP-specific phosphodiesterase 3A (PDE3A) and PDE4D5; the latter is the only PDE4D isoform expressed in smooth muscle...
  80. ncbi Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen
    Eric P Rahrmann
    Department of Genetics, Cell Biology, and Development and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Cancer Res 69:4388-97. 2009
    ..analysis of transposon insertions identified candidate prostate cancer genes at common insertion sites, including Pde4d. PDE4D was also overexpressed in human prostate cancer patient samples and cell lines, and changes in PDE4D mRNA ..
  81. ncbi Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D
    Hong Zhu
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 30:4379-90. 2010
    ..calcineurin binds directly to and inhibits the proteosomal degradation of cAMP-hydrolyzing phosphodiesterase 4D (PDE4D)...
  82. ncbi Subtype selectivity in phosphodiesterase 4 (PDE4): a bottleneck in rational drug design
    P Srivani
    Molecular Modeling Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India
    Curr Pharm Des 14:3854-72. 2008
    ..followed by a detailed structural analysis of more than three dozen available X-ray structures of PDE4B and PDE4D. Usually, the lack of a 3-dimensional structure of a target protein is a bottleneck for rational drug design ..
  83. ncbi Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme
    Judith A Siuciak
    CNS Discovery Research, Pfizer Global Research and Development, Groton, CT, 06340, USA
    Psychopharmacology (Berl) 197:115-26. 2008
    ..Four separate PDE4 genes (PDE4A, PDE4B, PDE4C, and PDE4D) have been identified...
  84. ncbi Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs
    Han Ting Zhang
    Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, Morgantown, WV 26506 9137, USA
    Curr Pharm Des 15:1688-98. 2009
    ..First, limited, but significant studies point to PDE4D as the major PDE4 subtype responsible for antidepressant-like effects of PDE4 inhibitors, although the role of ..
  85. ncbi Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)
    Han Ting Zhang
    Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Neuropsychopharmacology 33:1611-23. 2008
    ..However, the functions of the four PDE4 subfamilies (PDE4A, PDE4B, PDE4C, and PDE4D) remain largely unknown...
  86. ncbi Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors
    R Hersperger
    Novartis Pharma AG, Research, CH 4002 Basel, Switzerland
    J Med Chem 43:675-82. 2000
    ..synthesis of 6,8-disubstituted 1,7-naphthyridines and their characterization as potent and selective inhibitors of PDE4D which suppress the oxidative burst in human eosinophils with IC(50) values as low as 0.7 nM...
  87. ncbi Effect of pregnancy on PDE4 cAMP-specific phosphodiesterase messenger ribonucleic acid expression in human myometrium
    M J Leroy
    Institut National de la Sante et de la Recherche Medicale, Unité U361, Maternité Port Royal Cochin, Universite Rene Descartes, Paris, France
    Cell Signal 11:31-7. 1999
    ..Concurrent expression of the PDE4A, 4B, 4C and 4D genes is demonstrated. We found that the PDE4D transcripts are the most prominently expressed...
  88. ncbi Development of decompensated dilated cardiomyopathy is associated with decreased gene expression and activity of the milrinone-sensitive cAMP phosphodiesterase PDE3A
    C J Smith
    Department of Pathology, New York Medical College, Valhalla 10595, USA
    Circulation 96:3116-23. 1997
    ..Little is known about relative changes in PDE3 activity or gene expression during the evolution of cardiomyopathy...
  89. ncbi The induction of cyclic nucleotide phosphodiesterase 4 gene (PDE4D) impairs memory in a water maze task
    Mauro Giorgi
    Department of Basic and Applied Biology, University of L Aquila, Via Vetoio, località Coppito, 67100 L Aquila, Italy
    Behav Brain Res 154:99-106. 2004
    ..RT-PCR analysis, together with Western blot immunodetection, showed a mRNA and protein induction of PDE4D PDE isoforms, that may account for the increase of PDE activity observed...
  90. ncbi Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 179:613-9. 2005
    ..Inhibition of cyclic AMP (cAMP)-specific phosphodiesterase (PDE4) enhances memory in rodents. MEM1018 and MEM1091 are newly developed PDE4 inhibitors that had not been evaluated as yet for their effects on working and reference memory...
  91. ncbi Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus
    F M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Mol Psychiatry 9:932-45, 895. 2004
    ..in which significant changes in gene expression were also noted for adenylate cyclase (AC4), phosphodiesterase (PDE4D), protein kinase A (PKA), and protein kinase C (PKC)...
  92. ncbi Research actuality in the genetics of stroke
    Antonio Orlacchio
    Laboratorio di Neurogenetica, I R C C S Santa Lucia, Rome, Italy
    Clin Exp Hypertens 28:191-7. 2006
    ..approaches has led to the identification of the first putative gene associated with common polygenic stroke, PDE4D, mapped to chromosome 5q21...
  93. ncbi DMSO-treated HL60 cells: a model of neutrophil-like cells mainly expressing PDE4B subtype
    C Jacob
    Fresnes Laboratories, Department of Biology, Pfizer Global R and D, 3 9, rue de la Loge, 94265 Fresnes, France
    Int Immunopharmacol 2:1647-56. 2002
    ..A change of their PDE4 subtype profile was also observed: PDE4B was the predominant isoenzyme, PDE4D was down-regulated and PDE4A was no longer detectable...
  94. ncbi Characterization of cAMP degradation by phosphodiesterases in the accessory olfactory system
    James A Cherry
    Department of Psychology, Boston University, 64 Cummington Street, Boston, MA 02215, USA
    Chem Senses 27:643-52. 2002
    ..We show that the cAMP-specific isoforms PDE4A and PDE4D are found preferentially in the apical and basal layers, respectively, of the VNO neuroepithelium and in the ..
  95. ncbi Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4)
    W Joseph Thompson
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36608, USA
    Biochem Pharmacol 63:797-807. 2002
    ..chain reaction identification of mRNAse supported these conclusions with the exception that PDE2 and PDE4D mRNA isoform transcripts were present...
  96. ncbi Gene expression in human peripheral blood mononuclear cells upon acute ischemic stroke
    C Grond-Ginsbach
    Dept of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol 255:723-31. 2008
    ..Ischemic stroke provokes a systemic inflammatory response. The purpose of this study was to characterize this response on the gene expression level in circulating mononuclear leukocytes from acute ischemic stroke (AIS) patients...
  97. ncbi Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors
    Ji Hyun Lee
    Department of Pharmacology, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
    J Biol Chem 282:10414-22. 2007
    ..CFTR, Shank2 was found to be physically and functionally associated with the cyclic nucleotide phosphodiesterase PDE4D that precludes cAMP/PKA signals in epithelial cells and mouse brains...
  98. ncbi Genetics of ischaemic stroke
    Martin Dichgans
    Department of Neurology, Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians University, D 81377 Munchen, Germany
    Lancet Neurol 6:149-61. 2007
    ..Genome-wide linkage studies in extended pedigrees from Iceland led to the identification of PDE4D and ALOX5AP...
  99. ncbi Advances in the genetic basis of coronary artery disease
    Qing Wang
    Department of Molecular Cardiology, Lerner Research Institute ND4 38, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Atheroscler Rep 7:235-41. 2005
    ..protein involved in synthesizing potent pro-inflammatory leukotrienes) on 13q12-13 for MI and stroke; and PDE4D (encoding phosphodiesterase 4D) on 5q12 for ischemic stroke...
  100. ncbi Relaxin and phosphodiesterases collaborate during decidualization
    Olaf Bartscha
    Institute for Hormone and Fertility Research, University of Hamburg, D 20251 Hamburg, Germany
    Ann N Y Acad Sci 1030:479-92. 2004
    ..The observations that expression of PDE4D transcripts were selectively increased by cAMP and that inhibition of protein kinase A by H89 to potentially block ..
  101. ncbi New advances in identifying genetic anomalies in stroke-prone probands
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurol Neurosci Rep 4:420-6. 2004
    ..In a landmark Icelandic study, linkage was established between stroke and a locus on chromosome 5q12 designated STRK1. Association studies continue to identify polymorphisms that predispose to stroke and to markers for ..

Research Grants74

  1. CRYSTAL STRUCT. OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE
    Hengming Ke; Fiscal Year: 2003
    ..2) the catalytic domain of PDE4B complexed with the inhibitors rolipram and iodonated cAMP, (3) full length PDE4D and its complexes with the inhibitors rolipram and denbufylline and (4) the catalytic domain of PDE3 and its ..
  2. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2006
    ..In the first Specific Aim, the biochemical changes that induce impaired ovulation and follicle function in the PDE4D null mice will be studied using granulosa cell cultures...
  3. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2007
    ..Initial work has demonstrated that low expression of PDE4D isoforms are associated with increased risk for both carotid and cardiogenic stroke...
  4. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 2009
    ..Initial work has demonstrated that low expression of PDE4D isoforms are associated with increased risk for both carotid and cardiogenic stroke...
  5. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark J Fisher; Fiscal Year: 2010
    ..Initial work has demonstrated that low expression of PDE4D isoforms are associated with increased risk for both carotid and cardiogenic stroke...
  6. Hormonal Regulation of Phosphodiestrases
    Marco Conti; Fiscal Year: 2010
    ..Indeed, our analysis of PDE4 KO phenotypes has provided initial evidence that PDE4D and PDE4B play distinct functions in the body...
  7. Canthinones as Human Isozyme Selective PDE4 Inhibitors
    KEVIN CZERWINSKI; Fiscal Year: 2002
    ..In addition, the human isozymes of PDE4 (PDE4A, PDE4C, PDE4D) are highly homologous to PDE4B...
  8. NEUROPSYCHOPHARMACOLOGY OF CYCLIC AMP PDE INHIBITORS
    JAMES O DONNELL; Fiscal Year: 2002
    ..First, experiments will be carried our to determine which PDE4 subtypes (PDE4A, PDE4B, PDE4D) are involved in the mediation of AD-like behavioral effects, as well as other CNS effects...
  9. NEUROPSYCHOPHARMACOLOGY OF CYCLIC AMP PDE INHIBITORS
    JAMES O DONNELL; Fiscal Year: 2007
    ..do so will require a better understanding of the roles of the PDE4 subtypes expressed in brain (PDE4A, PDE4B, and PDE4D) in mediating the behavioral effects of PDE4 inhibitors...
  10. Spatiotemporal regulation of beta adrenoceptor signaling in cardiacmyocytes
    Yang K Xiang; Fiscal Year: 2011
    ..Aim 1. To characterize the effects of subtype-specific bAR/PDE4D complexes on spatiotemporal cAMP/PKA signaling propagation in cardiac myocytes...
  11. Novel prostate cancer oncogenes identified by transposon mutagenesis
    Paul C Marker; Fiscal Year: 2010
    ..One of the first genes identified in the mouse screen, PDE4D, was also over-expressed in human prostate cancer patient samples...
  12. Vascular tone & cAMP phosphodiesterase in angioplasty
    Carolyn Smith; Fiscal Year: 2002
    ..Aim lB: To determine the time course of PDE4B, PDE4D and PDE3A protein splice variants in RASMC stimulated with serum, PDGF-BB or bFGF...
  13. HORMONAL REGULATION OF PHOSPHODIESTERASES
    ANITA PAYNE; Fiscal Year: 2005
    ..In the first Specific Aim, the biochemical changes that induce impaired ovulation and follicle function in the PDE4D null mice will be studied using granulosa cell cultures...
  14. SALIVARY SECRETION-ROLE OF CALCIUM
    EILEEN WATSON; Fiscal Year: 2005
    ..of PDE4 isoenzymes which will be identified by immunoprecipitation and immunoblot analysis with specific PDE4D antibodies, and PDE assays, and amylase release...
  15. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2001
    ..In the second specific aim, the role of the different PDE variants originating from the PDE4D gene will be investigated...
  16. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Susana Neves; Fiscal Year: 2005
    ..This loop involves the differential expression of the cyclic nucleotide phosphodiesterase PDE4D long and short isoforms...
  17. MULTICENTERED STUDY OF STROKE GENETICS
    JAMES MESCHIA; Fiscal Year: 2004
    ..A centralized stroke verification committee will assure and accuracy in stroke phenotyping. DNA banking will be done to permitted future collaborative efforts to study the genetic basis for stroke risk. ..
  18. ISGS: The Ischemic Stroke Genetics Study
    JAMES MESCHIA; Fiscal Year: 2006
    ..The application and SWISS share the same definitions for the present and absence of phenotype and key enrollment criteria. ..
  19. REGULATION OF THE CAMP SPECIFIC PHOSPHODIESTERASES
    Graeme Bolger; Fiscal Year: 2003
    ..5. The two-hybrid system will be used to clone cDNAs encoding proteins that interact with 4 novel PDE4 isoforms. ..
  20. Genomewide search for modifiers of severity in beta-tha*
    Andreas Braun; Fiscal Year: 2004
    ..To our knowledge, using 100,000 gene-based SNPs, this will be the largest genomewide association study ever undertaken in an attempt to identify disease susceptibility or protective alleles. ..
  21. GENES FOR VASCULAR MORPHOGENESIS: A GENETIC APPROACH
    Qing Wang; Fiscal Year: 2003
    ..Moreover, understanding the genetic mechanisms underlying KTS offers possibilities for treatment of KTS as well as conditions such as cancer that depend on angiogenesis. ..