Gene Symbol: PDCD1LG2
Description: programmed cell death 1 ligand 2
Alias: B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2, programmed cell death 1 ligand 2, B7 dendritic cell molecule, B7-DC, PD-1-ligand 2, PDCD1 ligand 2, butyrophilin B7-DC, programmed death ligand 2
Species: human
Products:     PDCD1LG2

Top Publications

  1. Brown J, Dorfman D, Ma F, Sullivan E, Munoz O, Wood C, et al. Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol. 2003;170:1257-66 pubmed
    ..PD-L1 is also highly expressed on most carcinomas but minimally expressed on adjacent normal tissue suggesting a role in attenuating antitumor immune responses. ..
  2. Saunders P, Hendrycks V, Lidinsky W, Woods M. PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. Eur J Immunol. 2005;35:3561-9 pubmed
    The B7 family member programmed death ligand 2 (PD-L2) has been implicated in both positive and negative regulation of T cell activity...
  3. Ma Y, Wang Z, Zhang A, Xu F, Zhao N, Xue J, et al. Human placenta-derived mesenchymal stem cells ameliorate GVHD by modulating Th17/Tr1 balance via expression of PD-L2. Life Sci. 2018;214:98-105 pubmed publisher
    ..Conversely, Tr1 cell number and TGF-β production were enhanced by hpMSCs. Moreover, knockdown of programmed death ligand 2 (PD-L2) increased Th17 cell number from PMA activated T cells co-cultured with hpMSCs...
  4. Ramalingam K, Kandasamy A, Joshua Stephen Chellakumar P. Production of eco-friendly fuel with the help of steam distillation from new plant source and the investigation of its influence of fuel injection strategy in diesel engine. Environ Sci Pollut Res Int. 2019;: pubmed publisher
    ..The IT and IP are speckled in the array of 21 degCA bTDC, 23 degCA bTDC and 25 degCA bTDC and 180, 200, 220 and 240 bar correspondingly...
  5. Takamori S, Takada K, Azuma K, Jogo T, Shimokawa M, Toyokawa G, et al. Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients. Ann Surg Oncol. 2019;: pubmed publisher
    ..The potential role of PD-L2 expression as a predictive biomarker for response to immunotherapy should be investigated in future studies. ..
  6. Ren T, Zheng B, Huang Y, Wang S, Bao X, Liu K, et al. Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. Cell Death Dis. 2019;10:261 pubmed publisher
    ..Furthermore, we demonstrate a regulatory role for PD-L2 on autophagy, as well as a relationship between autophagy and metastasis in osteosarcoma, which may represent a potential therapeutic target for osteosarcoma. ..
  7. Zhou X, Busemann A, Meijer M, Siegler M, Bonnet S. The two isomers of a cyclometallated palladium sensitizer show different photodynamic properties in cancer cells. Chem Commun (Camb). 2019;55:4695-4698 pubmed publisher
    ..e. going from PdL1 (N^N^C^N) to PdL2 (N^N^N^C), dramatically influences the photodynamic properties of the complex in cancer cells...
  8. Matsubara T, Takada K, Azuma K, Takamori S, Toyokawa G, Haro A, et al. A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma. Ann Surg Oncol. 2019;: pubmed publisher
    ..PD-L2 protein expression was associated with prognosis in primary lung SCC patients. PD-L2 expression might be a potential biomarker for response to PD-1/PD-L1-targeted immunotherapy, which should be investigated in future studies. ..
  9. Kazemi Z, Amiri Rudbari H, Sahihi M, Mirkhani V, Moghadam M, Tangestaninejad S, et al. Synthesis, characterization and separation of chiral and achiral diastereomers of Schiff base Pd(II) complex: A comparative study of their DNA- and HSA-binding. J Photochem Photobiol B. 2016;163:246-60 pubmed publisher
    ..to separate diastereomeric pairs of Pd(II) complex: (mesoPdL2) and (racPdL2) that in this paper are known as PdL2(1) and PdL2(2), respectively...

More Information

Publications155 found, 100 shown here

  1. Wang Y, Wang X, Zhang K, Wang X, Xin X, Fan W, et al. Solvent-induced terbium metal-organic frameworks for highly selective detection of manganese(ii) ions. Dalton Trans. 2019;48:2569-2573 pubmed publisher
    ..Herein, by utilizing the solvent regulation approach, a pair of terbium metal-organic frameworks (UPC-36, [Tb2(btdc)3(DMF)(H2O)4]·DMF and UPC-37, [Tb2(btdc)3(H2O)6]) based on a π-electron-rich ligand (H2btdc = 2,2'-bithiophene-5,..
  2. Stempin C, Motrán C, Aoki M, Falcón C, Cerbán F, Cervi L. PD-L2 negatively regulates Th1-mediated immunopathology during Fasciola hepatica infection. Oncotarget. 2016;7:77721-77731 pubmed publisher
    ..AAM expressing the co-inhibitory molecule programmed death ligand 2 (PD-L2), which is capable of binding programmed death 1 (PD-1) expressed on activated T cells, have been ..
  3. Wolkow N, Jakobiec F, Afrogheh A, Eagle R, Pai S, Faquin W. Programmed Cell Death 1 Ligand 1 and Programmed Cell Death 1 Ligand 2 Are Expressed in Conjunctival Invasive Squamous Cell Carcinoma: Therapeutic Implications. Am J Ophthalmol. 2019;200:226-241 pubmed publisher
    ..Tissue expression of programmed cell death 1 ligand 1 (PD-L1) and programmed cell death 1 ligand 2 (PD-L2) has been shown to predict tumor response to these drugs...
  4. Yi J, Chen Z, Xu F, Wang Z, Zhang A, Liu T, et al. IL-27 Promotes Human Placenta-Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4+IL-10+IFN-γ+ T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease. J Immunol. 2019;202:1124-1136 pubmed publisher
    ..Activation occurred through increases in the expression of programmed death ligand 2 (PDL2) in hPMSCs via the JAK/STAT signaling pathway...
  5. Kumar A, Kishore P, Raju K, Kasianantham N, Bragadeshwaran A. Engine parameter optimization of palm oil biodiesel as alternate fuel in CI engine. Environ Sci Pollut Res Int. 2019;26:6652-6676 pubmed publisher
    ..The test outcomes revealed that 20% mix of palm oil at 27° bTDC with exhaust gas blending of 20% generated higher brake thermal efficiency, higher peak pressure, and less ..
  6. Venu H, Dinesh Babu M. Improvement of ternary fuel combustion with various injection pressure strategies in a toroidal re-entrant combustion chamber. Environ Sci Pollut Res Int. 2018;25:32024-32043 pubmed publisher
    ..respectively and are operated in toroidal re-entrant chamber geometry (TG) at an injection timing of 22 obTDC. From experimentation, it was identified that, for TG-HPF, higher injection pressure of 22 MPa ensued highest BTE (..
  7. Kaczmarek M, Banaszewski J, Leszczyńska M, Łagiedo Żelazowska M, Nowicka A, Romańska A, et al. High frequency of macrophages expressing elevated level of CD80, PD-Ls and TLR1 in nasal polyps of CRS patients. Immunobiology. 2019;224:154-162 pubmed publisher
    ..In our study, we observed a significantly higher level of CD80, CD274, CD273 and TLR1 in nasal polyps compared to blood samples from patients with CRSwNP...
  8. Rogers T, Christenson J, Greene L, O Neill K, Williams M, Gordon M, et al. Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression. Mol Cancer Res. 2019;17:30-41 pubmed publisher
    ..a classic EMT signature, miR-200c repressed many genes encoding immunosuppressive factors including CD274/CD273, HMOX-1, and GDF15...
  9. Pozdeyev N, Gay L, Sokol E, Hartmaier R, Deaver K, Davis S, et al. Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers. Clin Cancer Res. 2018;24:3059-3068 pubmed publisher
    ..tyrosine kinase genes KDR, KIT, and PDGFRA, amplification of immune evasion genes CD274, PDCD1LG2, and JAK2, and activating point mutations in small GTPase RAC1 were associated with ATC...
  10. Tierney J, Vogle A, Poirier J, Min I, Finnerty B, Zarnegar R, et al. Expression of programmed death ligand 1 and 2 in adrenocortical cancer tissues: An exploratory study. Surgery. 2019;165:196-201 pubmed publisher
    ..Immunohistochemistry was performed for programmed death ligand 1, programmed death ligand 2, and CD8 and scored for membranous staining on adrenal and stromal tissue according to the ..
  11. Tordesillas L, Lozano Ojalvo D, Dunkin D, Mondoulet L, Agudo J, Merad M, et al. PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs. Nat Commun. 2018;9:5238 pubmed publisher
    ..These results indicate an important function for hair follicle niche and CD11b+ cDC2s in antigen acquisition, and in generation of primary immune tolerance to topical antigens. ..
  12. Kwak O, Arooj M, Yoon Y, Jeong E, Park J. Orbital interaction and electron density transfer in PdII([9]aneB2A)L2 complexes: theoretical approaches. Molecules. 2013;18:12687-706 pubmed publisher
    ..orbital interaction towards equatorial or axial (soft A…Pd) coordination of macrocyclic [9]aneB2A tridentate to PdL2, and electron density transfer from the electron-rich trans L-ligand to the low-lying unfilled a1g(5s)-orbital of ..
  13. Steidl C, Shah S, Woolcock B, Rui L, Kawahara M, Farinha P, et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature. 2011;471:377-81 pubmed publisher
    ..class II expression and overexpression of ligands of the receptor molecule programmed cell death 1 (CD274/PDL1 and CD273/PDL2)...
  14. Camilleri E, Gustafson M, Dudakovic A, Riester S, Garces C, Paradise C, et al. Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production. Stem Cell Res Ther. 2016;7:107 pubmed publisher
    ..e., CD36, CD163, CD271, CD200, CD273, CD274, CD146, CD248, and CD140B) that may potentially discriminate AMSCs from other cell types...
  15. Saha A, Aoyama K, Taylor P, Koehn B, Veenstra R, Panoskaltsis Mortari A, et al. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 2013;122:3062-73 pubmed publisher
    ..Taken together, these data provide new insight into the differential roles of host PD-L1 and PD-L2 and their associated cellular and metabolic mechanisms controlling acute GVHD. ..
  16. Gulati N, Suárez Fariñas M, Correa Da Rosa J, Krueger J. Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions. F1000Res. 2015;4:149 pubmed publisher
    ..4 (CTLA4), programmed cell death 1 (PD1), programmed cell death 1 ligand 1 (PDL1), programmed cell death 1 ligand 2 (PDL2), and indoleamine 2,3-dioxygenase (IDO1)...
  17. Zhou X, Louissaint A, Wenzel A, Yang J, Martínez Escala M, Moy A, et al. Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type. J Invest Dermatol. 2018;138:2365-2376 pubmed publisher
    ..0% of DLBCLs-not otherwise specified) harbored PDL1/PDL2 translocations, which lead to overexpression of PD-L1 or PD-L2 in 50% of the cases...
  18. Machado Rugolo J, Fabro A, Ascheri D, Farhat C, Ab Saber A, de Sá V, et al. Usefulness of complementary next-generation sequencing and quantitative immunohistochemistry panels for predicting brain metastases and selecting treatment outcomes of non-small cell lung cancer. Hum Pathol. 2019;83:177-191 pubmed publisher
    ..Patients with a solid ADC subtype and mutated genes EGFR, CTLA4, PDCD1LG2, or ZEB1 complemented with PD-L1 or p53 protein lower expression that only underwent surgical treatment who ..
  19. Du G, Qin X, Li Q, Zhou Y, Shen X, Tang G. The high expression level of programmed death-1 ligand 2 in oral lichen planus and the possible costimulatory effect on human T cells. J Oral Pathol Med. 2011;40:525-32 pubmed publisher
    ..05). These data show that the increased expression of PD-L2, as a costimulatory molecule, may have an important modulatory function on the local immune responses of OLP in vivo. ..
  20. Remon J, Chaput N, Planchard D. Predictive biomarkers for programmed death-1/programmed death ligand immune checkpoint inhibitors in nonsmall cell lung cancer. Curr Opin Oncol. 2016;28:122-9 pubmed publisher
    ..Care should be also taken when using anti-PD-1/PD-L1 therapies in combination with other therapies, which may impact the predictive value of PD-L1 expression. ..
  21. Ho C, Rodig S. Immunohistochemical markers in lymphoid malignancies: Protein correlates of molecular alterations. Semin Diagn Pathol. 2015;32:381-91 pubmed publisher
    ..MYC; BCL2), somatic mutations (BRAF V600E; NOTCH1), and gene copy number gains (CD274 (encoding PD-L1); PDCD1LG2 (encoding PD-L2)) in fixed tissue biopsy sections...
  22. Damodharan D, Sathiyagnanam A, Rajesh Kumar B, Ganesh K. Cleaner emissions from a DI diesel engine fueled with waste plastic oil derived from municipal solid waste under the influence of n-pentanol addition, cold EGR, and injection timing. Environ Sci Pollut Res Int. 2018;25:13611-13625 pubmed publisher
    ..Smoke density for WPO70P30 was found to be twice lower than that of neat WPO at standard injection timing of 23°CA bTDC at any given EGR rate, NOx emissions were slightly on the higher side about 12% for WPO70P30 blend against WPO at ..
  23. Vats B, Kannan S, Sundararajan M, Kumar M, Drew M. Synthesis, structural and theoretical studies of dithiodiglycolamide compounds of palladium(II). Dalton Trans. 2015;44:11867-76 pubmed publisher
    ..5); X = I, L = (CH2SCH2CON(i)Bu2)2 (6)), whereas palladium(ii) nitrate yielded compounds of the type [PdL2](NO3)2 (where L = (CH2SCH2CON(i)Pr2)2 (7); L = (CH2SCH2CON(i)Bu2)2 (8))...
  24. Singh A, Stock P, Akbari O. Role of PD-L1 and PD-L2 in allergic diseases and asthma. Allergy. 2011;66:155-62 pubmed publisher
    ..Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was shown to regulate T-cell activation and tolerance...
  25. Lee R, Mao C, Vo H, Gao W, Zhong X. Fluorescence tagging and inducible depletion of PD-L2-expressing B-1 B cells in vivo. Ann N Y Acad Sci. 2015;1362:77-85 pubmed publisher
    L2pB1 cells are a subpopulation of B-1a B cells that express programmed death ligand 2 (PD-L2) as their unique cell surface marker. In mice, about 50% of peritoneal B-1a cells are L2pB1 cells...
  26. Adam I, Heikal M, Aziz A, Yusup S. Mitigation of NOx emission using aromatic and phenolic antioxidant-treated biodiesel blends in a multi-cylinder diesel engine. Environ Sci Pollut Res Int. 2018;25:28500-28516 pubmed publisher
    ..The start of combustion angles (SOC) of PB blends was - 13.2 to - 15.6 °CA BTDC, but the combustion delays were 5.4-7...
  27. Yoon H, Park S, Ju H, Ha S, Sohn I, Jo J, et al. Integrated copy number and gene expression profiling analysis of Epstein-Barr virus-positive diffuse large B-cell lymphoma. Genes Chromosomes Cancer. 2015;54:383-96 pubmed publisher
    ..An integrated analysis indicated that SLAMF1 and PDL2 were key targets of the gains detected at 1q23.2-23.3 and 9p24.1. The chromosomal gain at 9p24...
  28. Cerkovnik P, Novakovic B, Stegel V, Novakovic S. Changes in expression of genes involved in antitumor immunity in mice vaccinated with tumor vaccine composed of irradiated syngeneic tumor cells and CpG oligodeoxynucleotides. Mol Immunol. 2016;79:1-13 pubmed publisher
    ..the activation of genes involved in generation of Treg and induction of immune tolerance (Sit1, Sla2, Cd1d1, Pdcd1lg2, Pawr, Socs5, Il27, Il4)...
  29. Care M, Westhead D, Tooze R. Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma. Genome Med. 2015;7:96 pubmed publisher
    ..a hierarchy of immune-regulatory gene expression that places IDO1, LAG3 and FGL2 ahead of PD1-ligands CD274 and PDCD1LG2. Immune responses in DLBCL converge onto the IFNγ-STAT1-IRF1 axis and link to diverse potential mediators of ..
  30. Cader F, Schackmann R, Hu X, Wienand K, Redd R, Chapuy B, et al. Mass cytometry of Hodgkin lymphoma reveals a CD4+ exhausted T-effector and T-regulatory cell rich microenvironment. Blood. 2018;: pubmed publisher
    ..1/CD274(PD-L1)/PDCD1LG2(PD-L2) genetic alterations, overexpression of the PD-1 ligands and associated T-cell exhaustion and ..
  31. Mottok A, Steidl C. Genomic alterations underlying immune privilege in malignant lymphomas. Curr Opin Hematol. 2015;22:343-54 pubmed publisher
    ..These prominently include structural genomic changes of the CIITA and programmed death ligand (CD274/PDCD1LG2) loci, alterations affecting antigen presentation and mutations in JAK-STAT and NFκB signaling pathways...
  32. Dimitrov V, Bouttier M, Boukhaled G, Salehi Tabar R, Avramescu R, Memari B, et al. Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice. J Biol Chem. 2017;292:20657-20668 pubmed publisher
  33. Pfistershammer K, Klauser C, Pickl W, Stockl J, Leitner J, Zlabinger G, et al. No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. Eur J Immunol. 2006;36:1104-13 pubmed
    ..Our results demonstrate that PD-L2 negatively regulates human T cell activation and thus might be a candidate molecule for immunotherapeutic approaches aimed to attenuate pathological immune responses. ..
  34. Gatalica Z, Xiu J, Swensen J, Vranic S. Comprehensive analysis of cancers of unknown primary for the biomarkers of response to immune checkpoint blockade therapy. Eur J Cancer. 2018;94:179-186 pubmed publisher
    ..Amplifications of CD274 (PD-L1) and PDCD1LG2 (PD-L2) genes were also rare (1.4% and 0.8%, respectively)...
  35. Howitt B, Sun H, Roemer M, Kelley A, Chapuy B, Aviki E, et al. Genetic Basis for PD-L1 Expression in Squamous Cell Carcinomas of the Cervix and Vulva. JAMA Oncol. 2016;2:518-22 pubmed publisher
    ..status of CD274 (encoding PD-L1 [programmed cell death 1 ligand 1]) and PDCD1LG2 (encoding PD-L2 [programmed cell death 1 ligand 2]) in SCCs of the cervix and vulva and to correlate the findings with PD-L1 protein expression...
  36. Pittet C, Newcombe J, Prat A, Arbour N. Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis. J Neuroinflammation. 2011;8:155 pubmed publisher
    ..However, such impact is impaired in MS lesions due to downregulation of endothelium PD-L2 levels. ..
  37. Montero Barrera D, Valderrama Carvajal H, Terrazas C, Rojas Hernández S, Ledesma Soto Y, Vera Arias L, et al. The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection. Biomed Res Int. 2015;2015:615865 pubmed publisher
    ..Flow cytometry and RT-PCR analyses showed overexpression of the mannose receptors, IL-4Rα, PDL2, arginase-1, Ym1, and RELM-α on MGL1(-/-) macrophages. These studies indicate that MGL1 is involved in T...
  38. Takahashi H, Sakakura K, Kawabata Iwakawa R, Rokudai S, Toyoda M, Nishiyama M, et al. Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma. Cancer Immunol Immunother. 2015;64:1407-17 pubmed publisher
    ..CAFs expressed the co-regulatory molecules, B7H1 and B7DC, whereas NFs did not...
  39. Barcia R, Santos J, Teixeira M, Filipe M, Pereira A, Ministro A, et al. Umbilical cord tissue-derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing. Cytotherapy. 2017;19:360-370 pubmed publisher
    ..the expression of relevant surface markers such as CD14, CD19, CD31, CD34, CD44, CD45, CD90, CD105, CD146, CD200, CD273, CD274 and HLA-DR...
  40. Sanlorenzo M, Vujic I, Floris A, Novelli M, Gammaitoni L, Giraudo L, et al. BRAF and MEK Inhibitors Increase PD-1-Positive Melanoma Cells Leading to a Potential Lymphocyte-Independent Synergism with Anti-PD-1 Antibody. Clin Cancer Res. 2018;24:3377-3385 pubmed publisher
    ..i>Clin Cancer Res; 24(14); 3377-85. ©2018 AACR. ..
  41. Huang C, Wong R, Wei J, Tsay M, Chen W, Chen H, et al. Effects of genetic polymorphisms of programmed cell death 1 and its ligands on the development of ankylosing spondylitis. Rheumatology (Oxford). 2011;50:1809-13 pubmed publisher
    ..Our results suggest that PD-1 G-536A, PD-L1 A8923C and PD-L2 C47103T polymorphisms are associated with the presence of AS. ..
  42. Ghavale N, Manjare S, Singh H, Butcher R. Bis(chalcogenones) as pincer ligands: isolation and Heck activity of the selone-ligated unsymmetrical C,C,Se-Pd pincer complex. Dalton Trans. 2015;44:11893-900 pubmed publisher
    ..The chelated complex of the type [PdL2](2+)2[PF6](-) (L = bis(selone)) was isolated from the reaction of the bis(selone) with [PdCl2(PhCN)2] and NH4PF6...
  43. Shi M, Roemer M, Chapuy B, Liao X, Sun H, Pinkus G, et al. Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain. Am J Surg Pathol. 2014;38:1715-23 pubmed publisher
    ..b>Programmed cell death 1 ligand 2 (PD-L2) is a cell surface protein expressed by activated macrophages and dendritic cells that binds ..
  44. Bianchini G, Pusztai L, Pienkowski T, Im Y, Bianchi G, Tseng L, et al. Immune modulation of pathologic complete response after neoadjuvant HER2-directed therapies in the NeoSphere trial. Ann Oncol. 2015;26:2429-36 pubmed publisher
    ..1%) were correlated with pCRB. We studied five selected genes (IFNG, PD1, PDL1, PDL2, CTLA4) and six immune metagenes corresponding to plasma cells (IGG), T cells (CD8A), antigen-presenting cells (..
  45. Horlad H, Ma C, Yano H, Pan C, Ohnishi K, Fujiwara Y, et al. An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma. Cancer Sci. 2016;107:1696-1704 pubmed publisher
    ..Although the significance of PD-L1/2 expressions on macrophages in lymphoma progression has never been clarified, an IL-27-Stat3 axis might be a target for immunotherapy for lymphoma patients. ..
  46. Giroux Leprieur E, Dumenil C, Julie C, Giraud V, Dumoulin J, Labrune S, et al. Immunotherapy revolutionises non-small-cell lung cancer therapy: Results, perspectives and new challenges. Eur J Cancer. 2017;78:16-23 pubmed publisher
    ..that target key signalling pathways such as programmed death 1 (PD1)/programmed death-ligands 1 and 2 (PDL1 and PDL2) to improve anti-tumour immune responses...
  47. Sponaas A, Moharrami N, Feyzi E, Standal T, Holth Rustad E, Waage A, et al. PDL1 Expression on Plasma and Dendritic Cells in Myeloma Bone Marrow Suggests Benefit of Targeted anti PD1-PDL1 Therapy. PLoS ONE. 2015;10:e0139867 pubmed publisher
    ..DCs are important in regulating T cell responses against tumors. We therefore determined PDL1 and PDL2 expression on DC populations in bone marrow of patients with plasma cell disorders using multicolour Flow Cytometry...
  48. Chiku V, Silva K, de Almeida B, Venturin G, Leal A, de Martini C, et al. PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis. Immunobiology. 2016;221:879-88 pubmed publisher
    ..a new member of the B7-CD28 family that is expressed by immune cells, and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces the deactivation or apoptosis of T cells...
  49. Bossi P, Siano M, Bergamini C, Cossu Rocca M, Sponghini A, Giannoccaro M, et al. Are Fusion Transcripts in Relapsed/Metastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?. Dis Markers. 2017;2017:6870614 pubmed publisher
    ..0027). The CD274-PDCD1LG2 fusion was present in 7/14 short PFS patients harboring fusions and was absent in long PFS patients (P = 0...
  50. Twa D, Mottok A, Savage K, Steidl C. The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies. Blood Rev. 2018;32:249-255 pubmed publisher
    ..CIITA, B2M, and HLA loci) and structural rearrangements of programmed death ligands 1 (CD274) and 2 (PDCD1LG2)...
  51. Menter T, Tzankov A. Genetic alterations of 9p24 in lymphomas and their impact for cancer (immuno-)therapy. Virchows Arch. 2019;474:497-509 pubmed publisher
    ..The most prominent genes of this locus are programmed death ligands 1 and 2 (PDL1/PDL2), with the amplification of PDL1 being a hallmark of both classical Hodgkin and primary mediastinal B cell lymphoma,..
  52. Twa D, Chan F, Ben Neriah S, Woolcock B, Mottok A, Tan K, et al. Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma. Blood. 2014;123:2062-5 pubmed publisher
    ..Our data suggest that recurrent genomic rearrangement events underlie an immune privilege phenotype in a subset of B-cell lymphomas. ..
  53. Saigi M, Alburquerque Béjar J, Mc Leer Florin A, Pereira C, Pros E, Romero O, et al. MET-Oncogenic and JAK2-Inactivating Alterations Are Independent Factors That Affect Regulation of PD-L1 Expression in Lung Cancer. Clin Cancer Res. 2018;24:4579-4587 pubmed publisher
    ..The activation of MET also upregulated other immunosuppressive genes (PDCD1LG2 and SOCS1) and transcripts involved in angiogenesis (VEGFA and NRP1) and in cell ..
  54. Otani T, Tsuji Takayama K, Okochi A, Yamamoto M, Takeuchi M, Yamasaki F, et al. Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line. Immunol Cell Biol. 2011;89:246-54 pubmed publisher
    ..molecules, and not MHC class II or other costimulatory molecules, such as ICOSL (CD275), PD-L1 (CD274), PD-L2 (CD273), CD40, OX40L (CD252) and 4-1BBL (CD137L) in the absence of stimulation...
  55. Daneshmandi S, Pourfathollah A, Karimi M, Emadi Baygi M. PDL-1/PDL-2 blockade in mice dendritic cells by RNAi techniques to induce antitumor immunity. Immunotherapy. 2015;7:1145-58 pubmed publisher
    ..Manipulated DCs induced significant antitumor immunity, but this subject needs further evaluation in different animals. ..
  56. Ansell S, Lesokhin A, Borrello I, Halwani A, Scott E, Gutierrez M, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med. 2015;372:311-9 pubmed publisher
    ..objectives were measurement of safety and efficacy and assessment of the PDL1 and PDL2 (also called CD274 and PDCD1LG2, respectively) loci and PD-L1 and PD-L2 protein expression...
  57. Gao Y, Li S, Xu D, Chen S, Cai Y, Jiang W, et al. Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma. Chin J Cancer. 2017;36:61 pubmed publisher
  58. Poole J, Mikuls T, Duryee M, Warren K, Wyatt T, Nelson A, et al. A role for B cells in organic dust induced lung inflammation. Respir Res. 2017;18:214 pubmed publisher
    ..of conventional B2-, innate B1 (CD19+CD11b+CD5+/-)-, and memory (CD19+CD273+/-CD73+/-) B cells following ODE exposure in WT mice...
  59. Yamamoto R, Nishikori M, Kitawaki T, Sakai T, Hishizawa M, Tashima M, et al. PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. Blood. 2008;111:3220-4 pubmed publisher
    ..Our finding provides a potentially effective immunologic strategy for the treatment of HL. ..
  60. Ellis J, Guloglu F, Zaghouani H. Presentation of high antigen-dose by splenic B220(lo) B cells fosters a feedback loop between T helper type 2 memory and antibody isotype switching. Immunology. 2016;147:464-75 pubmed publisher
    ..peritoneal B220(lo) cells were most effective in sustaining Th2 memory development as well as immunoglobulin isotype switching, and this function involved a tight control by programmed death 1-programmed death ligand 2 interactions.
  61. Van Roosbroeck K, Ferreiro J, Tousseyn T, van der Krogt J, Michaux L, Pienkowska Grela B, et al. Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies. Genes Chromosomes Cancer. 2016;55:428-41 pubmed publisher
    ..in lymphoid malignancies potentially involving four cancer-related and druggable genes (JAK2, CD274/PDL1, PDCD1LG2/PDL2, and KDM4C/JMJD2Cl) are incompletely characterized...
  62. Lin L, Maestá I, Braga A, Sun S, Fushida K, Francisco R, et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review. Gynecol Oncol. 2017;145:88-95 pubmed publisher
    ..from New England Trophoblastic Disease Center (NETDC) (1966-2015) and four Brazilian Trophoblastic Disease Centers (BTDC) (1990-2015). From a total of 12,455 cases of gestational trophoblastic disease seen, 72 CHMCF were identified...
  63. Latchman Y, Wood C, Chernova T, Chaudhary D, Borde M, Chernova I, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001;2:261-8 pubmed
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses. ..
  64. Riccomi A, Palma C. B Cells and Programmed Death-Ligand 2 Signaling Are Required for Maximal Interferon-γ Recall Response by Splenic CD4⁺ Memory T Cells of Mice Vaccinated with Mycobacterium tuberculosis Ag85B. PLoS ONE. 2015;10:e0137783 pubmed publisher
    ..tuberculosis antigens. We also invite to consider B cells, PD-L2 and PI3K as potential targets for therapeutic modulation of T cell cytokine responses for tuberculosis control. ..
  65. Xu J, Sun H, Fletcher C, Hornick J, Morgan E, Freeman G, et al. Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders. Am J Surg Pathol. 2016;40:443-53 pubmed publisher
    ..PD-L1 and PD-L2 are useful new markers for identifying select histiocyte and dendritic cell disorders and reveal novel patient populations as rational candidates for immunotherapy. ..
  66. Harakal J, Rival C, Qiao H, Tung K. Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis. J Immunol. 2016;197:27-41 pubmed publisher
    ..Furthermore, expansion of both Th2-promoting IFN regulatory factor 4(+) programmed death ligand 2(+) dendritic cells and ILT3(+) rebounded Tregs was detected after transient Treg depletion...
  67. Nagamatsu T, Schust D, Sugimoto J, Barrier B. Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions. Hum Reprod. 2009;24:3160-71 pubmed publisher
    ..This helps to maintain a balanced cytokine milieu at the feto-maternal interface. ..
  68. Mathios D, Ruzevick J, Jackson C, Xu H, Shah S, Taube J, et al. PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment. J Neurooncol. 2015;121:251-9 pubmed publisher
    ..Its ligands, PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273), are expressed on a variety of human cancers; however this pathway has not been previously reported in chordomas...
  69. Deng J, Qian Y, Geng L, Xie H, Wang Y, Jiang G, et al. Involvement of ERK and JNK pathways in IFN-?-induced B7-DC expression on tumor cells. J Cancer Res Clin Oncol. 2011;137:243-50 pubmed publisher
    ..Our findings demonstrate that the pretreatment of tumor cells with IFN-? enhances B7-DC expression through ERK and JNK pathways. ..
  70. Meshkibaf S, Martins A, Henry G, Kim S. Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages. Cytokine. 2016;78:69-78 pubmed publisher
    ..factor (M-CSF) (G-BMDM) expressed higher levels of regulatory macrophage markers such as programmed death ligand 2 (PDL2), CD71 and CD206, but not in arginase I, transforming growth factor (TGF)-β, Ym1 (chitinase-..
  71. Xerri L, Chetaille B, Serriari N, Seriari N, Attias C, Guillaume Y, et al. Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Hum Pathol. 2008;39:1050-8 pubmed publisher
    ..Because the anti-PD-1.6.4 antibody works on paraffin sections, it represents a useful tool to differentiate SLL/CLL from other small B-cell lymphomas. ..
  72. Kazemi Z, Rudbari H, Sahihi M, Mirkhani V, Moghadam M, Tangestaninejad S, et al. Synthesis, characterization and biological application of four novel metal-Schiff base complexes derived from allylamine and their interactions with human serum albumin: Experimental, molecular docking and ONIOM computational study. J Photochem Photobiol B. 2016;162:448-462 pubmed publisher
    Novel metal-based drug candidate including VOL2, NiL2, CuL2 and PdL2 have been synthesized from 2-hydroxy-1-allyliminomethyl-naphthalen ligand and have been characterized by means of elemental analysis (CHN), FT-IR and UV-vis ..
  73. Fukasawa T, Yoshizaki A, Ebata S, Nakamura K, Saigusa R, Miura S, et al. Contribution of Soluble Forms of Programmed Death 1 and Programmed Death Ligand 2 to Disease Severity and Progression in Systemic Sclerosis. Arthritis Rheumatol. 2017;69:1879-1890 pubmed publisher
    ..These results suggest that sPD-1 and sPD-L2 contribute to disease development in SSc via the regulation of cognate interactions with T cells and B cells. ..
  74. Kelly R. Immunotherapy for Esophageal and Gastric Cancer. Am Soc Clin Oncol Educ Book. 2017;37:292-300 pubmed publisher
  75. Froidure A, Vandenplas O, D Alpaos V, Evrard G, Pilette C. Persistence of asthma following allergen avoidance is associated with proTh2 myeloid dendritic cell activation. Thorax. 2015;70:967-73 pubmed publisher
    ..disease increased the production of interleukin (IL) 5 and IL-13 by CD4(+) T cells, and upregulated programmed death ligand 2 (PD-L2) upon allergen pulsing...
  76. Wang P, Wang J, Zhou Y, Chen X, Zhou K, Wen J, et al. Expression of programmed death-1 and its ligands in the liver of biliary atresia. World J Pediatr. 2017;13:604-610 pubmed publisher
    ..Only PD-1 and PD-L1 are involved in the immune reactions of early BA. Elucidation of the detailed role of PD-L2 in BA requires further research. ..
  77. D Souza L, Gupta S, Bal V, Rath S, George A. CD73 expression identifies a subset of IgM+ antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent. Immunology. 2017;152:602-612 pubmed publisher
    ..Further, expression of CD73, CD80 and CD273 has allowed the categorization of B-cell memory into multiple subsets, with combinatorial expression of the ..
  78. Wang S, Lin C, Li R, Ou T, Wu C, Tsai W, et al. Polymorphisms of genes for programmed cell death 1 ligands in patients with rheumatoid arthritis. J Clin Immunol. 2007;27:563-7 pubmed
    ..This study demonstrated that the PD-L1 and PD-L2 polymorphisms were not associated with susceptibility to RA in Taiwan. PD-L1 6777 G was associated with the prevalence of rheumatoid nodule. ..
  79. Cramer M, Shao G, Rodino Klapac L, Chicoine L, Martin P. Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone. Hum Gene Ther. 2017;28:493-509 pubmed publisher
    ..AAV-transduced skeletal muscles also had elevated expression of programmed death ligand 2 (PDL2) on skeletal myofibers, and this increase in expression extended to muscles where transgene was ..
  80. Messal N, Serriari N, Pastor S, Nunes J, Olive D. PD-L2 is expressed on activated human T cells and regulates their function. Mol Immunol. 2011;48:2214-9 pubmed publisher
    ..These observations indicate that PD-L2 is expressed following activation and is involved in the regulation of T cell function, highlighting the level of complexity in the T cell cosignaling network. ..
  81. Mo Z, Liu J, Zhang Q, Chen Z, Mei J, Liu L, et al. Expression of PD-1, PD-L1 and PD-L2 is associated with differentiation status and histological type of endometrial cancer. Oncol Lett. 2016;12:944-950 pubmed
    ..Programmed cell death protein 1 (PD-1) and its ligands programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2) have been well studied in lung cancer, melanoma and renal-cell cancer...
  82. Qu Y, Lin Q, Yuan Y, Sun Z, Li P, Wang F, et al. Cyclosporin A inhibits adipogenic differentiation and regulates immunomodulatory functions of murine mesenchymal stem cells. Biochem Biophys Res Commun. 2018;498:516-522 pubmed publisher
    ..In conclusion, our results proposed that CsA may exert an effect on regulating the bone marrow environment by influencing BM-MSCs, which have a beneficial effect on treating AA. ..
  83. Ryan R, Drier Y, Whitton H, Cotton M, Kaur J, Issner R, et al. Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma. Cancer Discov. 2015;5:1058-71 pubmed publisher
    ..This method detects rearrangements involving known cancer genes, including CCND1, BCL2, MYC, PDCD1LG2, NOTCH1, CIITA, and SGK1, as well as novel enhancer duplication events of likely oncogenic significance...
  84. Poncini C, Ilarregui J, Batalla E, Engels S, Cerliani J, Cucher M, et al. Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms. J Immunol. 2015;195:3311-24 pubmed publisher
    ..Concomitant with the upregulation of immune inhibitory mediators, including IL-10, TGF-β1, IDO, and programmed death ligand 2, T. cruzi infection induced an early increase of Gal-1 expression in vivo...
  85. Chen J, Wang Q, Yin D, Vu V, Sciammas R, Chong A. Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients. J Immunol. 2015;195:4069-73 pubmed publisher
    ..were shown to harbor H-2K(d)-specific IgG(+) memory B cells with a post-germinal center phenotype (CD73(+)CD273(+)CD38(hi)CD138(-)GL7(-))...
  86. Geng F, Liu J, Guo Y, Li C, Wang H, Wang H, et al. Persistent Exposure to Porphyromonas gingivalis Promotes Proliferative and Invasion Capabilities, and Tumorigenic Properties of Human Immortalized Oral Epithelial Cells. Front Cell Infect Microbiol. 2017;7:57 pubmed publisher
    ..of bioinformatics analyses and validation assays, tumor-related genes such as NNMT, FLI1, GAS6, lncRNA CCAT1, PDCD1LG2, and CD274 may be considered as the key regulators in tumor-like transformation in response to long-time exposure ..
  87. Wang G, Wang F, Li H, Zhang L, Luan X. [PD-L1/PD-L2 on human placenta-derived mesenchymal stem cells inhibits the IL-17 secretion of peripheral blood T cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:132-6 pubmed
    ..PD-L1 and PD-L2 expressed on hPMSCs could inhibit the hPMSCs-mediated up-regulation on the expression of IL-17 secreted by peripheral blood T cells. ..
  88. Inoue Y, Yoshimura K, Mori K, Kurabe N, Kahyo T, Mori H, et al. Clinical significance of PD-L1 and PD-L2 copy number gains in non-small-cell lung cancer. Oncotarget. 2016;7:32113-28 pubmed publisher
    ..Therefore, we conclude that an increase in PD-L1 gene copy number can be a feasible alternative biomarker for predicting response to anti-PD-1/PD-L1 therapy. ..
  89. Danilova L, Wang H, Sunshine J, Kaunitz G, Cottrell T, Xu H, et al. Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors. Proc Natl Acad Sci U S A. 2016;113:E7769-E7777 pubmed
    ..This study elucidates the highly interdependent nature of these parameters, and also indicates that future biomarkers for anti-PD-1/PD-L1 will benefit from tumor-type-specific, integrated, mRNA, protein, and genomic approaches. ..
  90. García Díaz A, Shin D, Moreno B, Saco J, Escuin Ordinas H, Rodriguez G, et al. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell Rep. 2017;19:1189-1201 pubmed publisher
    ..Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression. ..
  91. Abelson A, Johansson C, Kozyrev S, Kristjansdottir H, Gunnarsson I, Svenungsson E, et al. No evidence of association between genetic variants of the PDCD1 ligands and SLE. Genes Immun. 2007;8:69-74 pubmed
    ..We do not find support for genetic association to SLE. This is the first genetic study of SLE and the PDCD1 ligands and the lack of association in several cohorts implies that these genes are not major risk factors for SLE. ..
  92. Ni R, Ihara K, Miyako K, Kuromaru R, Inuo M, Kohno H, et al. PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. Hum Genet. 2007;121:223-32 pubmed
    ..In conclusion, the genetic evaluation by association study demonstrated that the PD-1 gene was a predisposing gene to the development of T1D mellitus in the Japanese population. ..