PCSK5

Summary

Gene Symbol: PCSK5
Description: proprotein convertase subtilisin/kexin type 5
Alias: PC5, PC6, PC6A, SPC6, proprotein convertase subtilisin/kexin type 5, prohormone convertase 5, proprotein convertase 6, protease PC6, subtilase, subtilisin/kexin-like protease PC5
Species: human
Products:     PCSK5

Top Publications

  1. Seidah N, Mayer G, Zaid A, Rousselet E, Nassoury N, Poirier S, et al. The activation and physiological functions of the proprotein convertases. Int J Biochem Cell Biol. 2008;40:1111-25 pubmed publisher
    ..Seven of them cleave after basic amino acids and are called PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7...
  2. Liu J, Afroza H, Rader D, Jin W. Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases. J Biol Chem. 2010;285:27561-70 pubmed publisher
    ..cell-based analysis of the interaction between ANGPTL3, furin, proprotein convertase subtilisin/kexin type 5 (PCSK5), paired amino acid converting enzyme-4 (PACE4), and LPL, we demonstrated that the cleavage of LPL by proprotein ..
  3. Seidah N, Prat A. The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov. 2012;11:367-83 pubmed
    ..Seven of these (proprotein convertase 1 (PC1), PC2, furin, PC4, PC5, paired basic amino acid cleaving enzyme 4 (PACE4) and PC7) activate cellular and pathogenic precursor proteins by ..
  4. Garten W, Braden C, Arendt A, Peitsch C, Baron J, Lu Y, et al. Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics. Eur J Cell Biol. 2015;94:375-83 pubmed publisher
    ..an enlarged cleavage site loop containing a multibasic amino acid motif, where the eukaryotic subtilases furin or PC5/6 cleave. Their ubiquitous presence in the organism allows a systemic virus infection...
  5. Osathanon T, Manokawinchoke J, Sa Ard Iam N, Mahanonda R, Pavasant P, Suwanwela J. Jagged1 promotes mineralization in human bone-derived cells. Arch Oral Biol. 2019;99:134-140 pubmed publisher
    ..The common genes differentially regulated of these two datasets were Hes1, Aph1a, Nsctn, Furin, Adam17, Hey1, Pcsk5, Nedd4, Jag1, Heyl, Notch3, Dlk1, and Hey2...
  6. Renauer P, Saruhan Direskeneli G, Coit P, Adler A, Aksu K, Keser G, et al. Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study. Arthritis Rheumatol. 2015;67:1361-8 pubmed publisher
    ..genes with suggestive levels of association (P < 1 × 10(-5)) with Takayasu arteritis, including PCSK5, LILRA3, PPM1G/NRBP1, and PTK2B...
  7. Magden E, Sleeper M, Buchl S, Jones R, Thiele E, Wilkerson G. Use of an Implantable Loop Recorder in a Chimpanzee (Pan troglodytes) to Monitor Cardiac Arrhythmias and Assess the Effects of Acupuncture and Laser Therapy. Comp Med. 2016;66:52-8 pubmed
    ..We used 2 well-known cardiac acupuncture sites on the wrist, PC6 (pericardium 6) and HT7 (heart 7), and evaluated the results of the therapy by using the ECG recordings from the ..
  8. Li J, Liu J, Lupino K, Liu X, Zhang L, Pei L. Growth Differentiation Factor 15 Maturation Requires Proteolytic Cleavage by PCSK3, -5, and -6. Mol Cell Biol. 2018;38: pubmed publisher
    ..We discovered that three members of the proprotein convertase, subtilisin/kexin-type (PCSK) family, namely, PCSK3, PCSK5, and PCSK6, can efficiently cleave GDF15 precursor, therefore licensing its maturation both in vitro and ..
  9. Cao Z, Sun L, Mou R, Zhou R, Zhu Z, Chen M. A novel method for the simultaneous analysis of seven biothiols in rice (Oryza sativa L.) using hydrophilic interaction chromatography coupled with electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;976-977:19-26 pubmed publisher
    ..However, both PC5 and PC6 were not detected throughout the stress experiment.

More Information

Publications157 found, 100 shown here

  1. Liu P, Cai W, Yu L, Yuan B, Feng Y. Determination of Phytochelatins in Rice by Stable Isotope Labeling Coupled with Liquid Chromatography-Mass Spectrometry. J Agric Food Chem. 2015;63:5935-42 pubmed publisher
    ..It was worth noting that PC5 was first identified and quantitated in rice tissues under Cd stress in the current study...
  2. Shi J, Ye Q, Zhao J, Liu J, Xu Z, Yi W, et al. EA promotes swallowing via activating swallowing-related motor neurons in the Nucleus Ambiguus. Brain Res. 2018;: pubmed publisher
    ..01). The excitatory neuron response rates were 66.67%, 71.11%, 42.22% and 35.56% for CV23, GV16, PC6 (Neiguan), and ST36 (Zusanli), respectively...
  3. Cheong K, Zhang J, Huang Y. The effectiveness of acupuncture in postoperative gastroparesis syndrome--a systematic review and meta-analysis. Complement Ther Med. 2014;22:767-86 pubmed publisher
    ..0001) respectively. All included RCTs reported positive effect of acupuncture in PGS treatment. ST36, CV12 and PC6 seemed to be the common acupoints selected...
  4. Aroxa F, Gondim I, Santos E, Coriolano M, Asano A, Asano N. Acupuncture as Adjuvant Therapy for Sleep Disorders in Parkinson's Disease. J Acupunct Meridian Stud. 2017;10:33-38 pubmed publisher
    ..executed using the acupuncture points LR3 (Taichong), SP6 (Sanyinjiao), LI4 (Hegu), TE5 (Wai-Guan), HT7 (Shenmen), PC6 (Neiguan), LI11 (Quchi), GB20 (Fengchi)...
  5. Lyu J, Liu X, Bi J, Jiao Y, Wu X, Ruan W. Characterization of Chinese white-flesh peach cultivars based on principle component and cluster analysis. J Food Sci Technol. 2017;54:3818-3826 pubmed publisher
    ..content, shikimic content and edible rate could be regarded as the characteristic indicators for PC1, PC2, PC3,PC4, PC5, PC6, PC7, PC8 and PC9, respectively...
  6. Demasi M, de S Molina E, Bowman Colin C, Lojudice F, Muras A, Sogayar M. Enhanced Proteolytic Processing of Recombinant Human Coagulation Factor VIII B-Domain Variants by Recombinant Furins. Mol Biotechnol. 2016;58:404-14 pubmed publisher
    ..By bioengineering CHO-DG44 cells to express stably the recombinant human endoproteases PACE, PACE-SOL, PCSK5, PCSK6, or PCKS7, we were able to achieve complete intra- or extracellular proteolytic processing of this rFVIII ..
  7. Zotelli V, Grillo C, Sousa M. A Case Report on the Effect of Sham Acupuncture. J Acupunct Meridian Stud. 2016;9:275-278 pubmed publisher
    ..The patient in this case report received nonpenetrating sham acupuncture at acupoint Neiguan (PC6), which resulted in the complete remission of nausea during an intra-oral impression-taking procedure, but it is ..
  8. Koistinen N, Bacanu S, Iverfeldt K. Phosphorylation of Fe65 amyloid precursor protein-binding protein in response to neuronal differentiation. Neurosci Lett. 2016;613:54-9 pubmed publisher
    ..Similar effects were observed in rat PC6.3 cells treated with nerve growth factor. The electrophoretic mobility shift was shown to be due to phosphorylation...
  9. Kim K, Kim D, Bae J, Son G, Kim K, Hong S, et al. Acupuncture and PC6 stimulation for the prevention of postoperative nausea and vomiting in patients undergoing elective laparoscopic resection of colorectal cancer: a study protocol for a three-arm randomised pilot trial. BMJ Open. 2017;7:e013457 pubmed publisher
    This study aims to assess the feasibility of acupuncture and a Pericardium 6 (PC6) wristband as an add-on intervention of antiemetic medication for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing ..
  10. Janež N, Peterka M, Accetto T. Complete Genome Sequences of Group III Campylobacter Bacteriophages PC5 and PC14. Genome Announc. 2016;4: pubmed publisher
    Here, we present the whole-genome sequences of bacteriophages PC5 and PC14 specific for Campylobacter jejuni, a leading cause of gastroenteritis in developed countries...
  11. Török A, Gulyás Z, Szalai G, Kocsy G, Majdik C. Phytoremediation capacity of aquatic plants is associated with the degree of phytochelatin polymerization. J Hazard Mater. 2015;299:371-8 pubmed publisher
    ..minor. In addition, PCs with higher degree of polymerization were only observed in L. minor (PC4, PC6 and PC7) while PC2 and PC3 occurred in E. canadensis and S. natans only...
  12. Enblom A, Johnsson A. Type and frequency of side effects during PC6 acupuncture: observations from therapists and patients participating in clinical efficacy trials of acupuncture. Acupunct Med. 2017;35:421-429 pubmed publisher
    Many therapists practise PC6 acupuncture for emesis (nausea and vomiting) during pregnancy, different cancer therapies, palliative care, after surgery, or to induce relaxing effects in general...
  13. Li T, Wu H, Soto Aguliar F, Huang L, Li W, Lao L, et al. Efficacy of electrical acupuncture on vascular cognitive impairment with no dementia: study protocol for a randomized controlled trial. Trials. 2018;19:52 pubmed publisher
    ..weeks (24 sessions in total), with the same acupoint prescription (DU20, EX-HN3, DU24, DU17, DU26, EX-HN1, HT7, PC6, GB20, SP6). The primary assessment is the Montreal Cognitive Assessment...
  14. Parker J, Lundgren L. Surfing the Waves of the CMJ; Are There between-Sport Differences in the Waveform Data?. Sports (Basel). 2018;6: pubmed publisher
    ..The main features of the movement cycles were characterized by magnitude (PC1 and PC5), waveform (PC2 and PC4), and phase shift features (PC3)...
  15. Gade C, Sharma N. Hybrid DNA i-motif: Aminoethylprolyl-PNA (pC5) enhance the stability of DNA (dC5) i-motif structure. Bioorg Med Chem Lett. 2017;27:5424-5428 pubmed publisher
    ..Hence aep-PNA C-rich sequence cytosine could be considered as potential DNA i-motif stabilizing agents in vivo conditions. ..
  16. Khan M, Latif M, Amil N, Juneng L, Mohamad N, Nadzir M, et al. Characterization and source apportionment of particle number concentration at a semi-urban tropical environment. Environ Sci Pollut Res Int. 2015;22:13111-26 pubmed publisher
    ..8 % variance) predominates with PNC in the fine and sub-microme tre range. PC2, PC3, PC4 and PC5 explain 16.5, 12.4, 6.0 and 5...
  17. Greco M, Sáez C, Contreras R, Rodríguez Rojas F, Bitonti M, Brown M. Cadmium and/or copper excess induce interdependent metal accumulation, DNA methylation, induction of metal chelators and antioxidant defences in the seagrass Zostera marina. Chemosphere. 2019;224:111-119 pubmed publisher
    ..Levels of glutathione (GSH) and phytochelatins (PCs) followed patterns similar to metal accumulation, with up to PC5, displaying adaptations in tolerance...
  18. Wang G, Tian Y, Jia S, Zhou W, Zhang W. Acupuncture regulates the heart rate variability. J Acupunct Meridian Stud. 2015;8:94-8 pubmed publisher
    Acupuncture is widely used in clinical practice. According to traditional acupuncture theory, the Neiguan acupoint (PC6) is one of the most commonly used acupoints and is indicated for treating cardiovascular-related disorders...
  19. Yang Y, Higgins C, Rehman I, Galvão K, Brito I, Bicalho M, et al. Genomic Diversity, Virulence, and Antimicrobial Resistance of Klebsiella pneumoniae Strains from Cows and Humans. Appl Environ Microbiol. 2019;85: pubmed publisher
    ..Furthermore, on two dairy farms, we identified a unique IncN-type plasmid, pC5, coharboring bla CTX-M-1 and mph(A) genes, which confer resistance to cephalosporins and ..
  20. Wang W, Li J, Meng X, Chen Y, Jing Q. [Effect of Electroacupuncture on ATP-sensitive Potassium Channel and Protein Kinase mRNA Ex- pression in Myocardial Ischemia Model Rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2017;37:448-452 pubmed
    ..Then they were randomly divided into 4 groups, i.e., the model group, Neiguan (PC6) group, Lieque (LU7) group, non-acupoint group, 10 in each group...
  21. Xiao J, Yi W, Wu L. Effects of electroacupuncture on reducing labor pain and complications in the labor analgesia process of combined spinal-epidural analgesia with patient-controlled epidural analgesia. Arch Gynecol Obstet. 2019;299:123-128 pubmed publisher
    ..Group 1 was first operated CSEA and PCEA, then EA at Hegu (LI4), Neiguan (PC6), Zusanli (ST36) and Sanyinjiao (SP6) by HANS-200A device for 25 min. Group 2 was only treated by CSEA and PCEA...
  22. Elhage R, Cheraï M, Levacher B, Darrasse Jèze G, Baillou C, Zhao X, et al. C-terminal cleavage of human Foxp3 at a proprotein convertase motif abrogates its suppressive function. Scand J Immunol. 2015;81:229-39 pubmed publisher
    ..Here, we show by transcriptome analysis that the proprotein convertases PCSK7, PCSK5 and Furin are present in human CD4(+) T cells with different expression patterns...
  23. Ma J, Evrard S, Badiola I, Siegfried G, Khatib A. Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF). Eur J Cell Biol. 2017;96:457-468 pubmed publisher
    ..Here, using the zebrafish fin regeneration model, we report induced expression of furin and PC5 but not PACE4 and PC7 during fin regeneration that is associated with increased PC activity...
  24. de Lima Pimentel R, Duque A, Moreira B, Rodrigues L. Acupuncture for the Treatment of Cardiovascular Diseases: A Systematic Review. J Acupunct Meridian Stud. 2019;12:43-51 pubmed publisher
    ..The most used acupoint was PC6 (10 studies, 64.7%), followed by ST36 (6 studies, 35.3%) and auricular acupoints (4 studies, 23.5%)...
  25. Kim W, Essalmani R, Szumska D, Creemers J, Roebroek A, D Orléans Juste P, et al. Loss of endothelial furin leads to cardiac malformation and early postnatal death. Mol Cell Biol. 2012;32:3382-91 pubmed publisher
    ..PCs) cleave secretory proteins after basic residues, and four of them are called furin-like PCs: furin, PC5, PACE4, and PC7. In vitro, they share many substrates...
  26. De Bie I, Marcinkiewicz M, Malide D, Lazure C, Nakayama K, Bendayan M, et al. The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. J Cell Biol. 1996;135:1261-75 pubmed
    The proprotein convertase PC5 is encoded by multiple mRNAs, two of which give rise to the COOH-terminal variant isoforms PC5-A (915 amino acids [aa]) and PC5-B (1877 aa)...
  27. Schmied Tobies M, Arroyo Abad U, Mattusch J, Reemtsma T. Mass spectrometric detection, identification, and fragmentation of arseno-phytochelatins. J Mass Spectrom. 2014;49:1148-55 pubmed publisher
    ..and mass spectrometric fragmentation of arseno-PC (As-PC) with PC of different degree of oligomerization (PC2-PC5) in solution were studied using liquid chromatography coupled in parallel to inductively coupled plasma mass ..
  28. Liu M, Wang C, Wu Z, Li N. Electroacupuncture for the prevention of postoperative gastrointestinal dysfunction in patients undergoing vascular surgery under general anesthesia: study protocol for a prospective practical randomized controlled trial. J Integr Med. 2014;12:512-9 pubmed publisher
    ..We aim to analyze the effectiveness of preventing PGD by preoperatively stimulating Neiguan (PC6), Zusanli (ST36) and Shangjuxu (ST37) bilaterally twice a day compared with sham-acupuncture treatment and standard ..
  29. Wang Q, Liang D, Wang F, Li W, Han Y, Zhang W, et al. Efficacy of electroacupuncture pretreatment for myocardial injury in patients undergoing percutaneous coronary intervention: A randomized clinical trial with a 2-year follow-up. Int J Cardiol. 2015;194:28-35 pubmed publisher
    ..EAP was conducted by 30-minute electrical stimulation through 4 electrodes attached to the Antiguan (PC6) and Ximen (PC4) acupoints in the forearm bilaterally 1-2h prior to PCI...
  30. Maccariello C, Franzini de Souza C, Morena L, Dias D, Medeiros M. Effects of acupuncture on the heart rate variability, cortisol levels and behavioural response induced by thunder sound in beagles. Physiol Behav. 2018;186:37-44 pubmed publisher
    ..the sound, the dogs underwent a 20-minute session of needle insertion at acupuncture points Yintang, GV20, HT7, PC6 and ST36 (ACUP), in non-points (NP) or left undisturbed (CTL)...
  31. Chen Y, Lee H, Lee M, WU Y, Lee Y, Hwang L, et al. Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray. Proc Natl Acad Sci U S A. 2018;115:E10720-E10729 pubmed publisher
    ..Here, we found that low-frequency median nerve stimulation (MNS) through acupuncture needles at the PC6 (Neiguan) acupoint (MNS-PC6) induced an antinociceptive effect that engaged this mechanism...
  32. Viana L, Gomes Marcondes M. A leucine-rich diet modulates the tumor-induced down-regulation of the MAPK/ERK and PI3K/Akt/mTOR signaling pathways and maintains the expression of the ubiquitin-proteasome pathway in the placental tissue of NMRI mice. Biol Reprod. 2015;92:49 pubmed publisher
    ..In the tumor-bearing group (MAC) only, the placental tissue showed increased PC5 mRNA expression, as assessed by quantitative RT-PCR, decreased 19S and 20S protein expression, as assessed by ..
  33. Zheng S, Pan X, Xu J, Xiu C, Dong Y, Zhu X. Variations in energy metabolism along the pericardium meridian and its relationship with visceral function adjustments during electroacupuncture. BMC Complement Altern Med. 2014;14:323 pubmed publisher
    ..blood perfusion units (BPU) along the pericardium meridian, and cardiac function during EA at Neiguan (PC6) to explore variations in energy metabolism and its relationship with visceral function adjustments during EA...
  34. Heng S, Dynon K, Li Y, Edgell T, Walton K, Rombauts L, et al. Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. Anal Biochem. 2015;475:14-21 pubmed publisher
    ..We have previously demonstrated that proprotein convertase 5/6A (PC6) is highly expressed in the receptive endometrium and that PC6 is critical for receptivity establishment in women...
  35. Makowski A, Granke M, Ayala O, Uppuganti S, Mahadevan Jansen A, Nyman J. Applying Full Spectrum Analysis to a Raman Spectroscopic Assessment of Fracture Toughness of Human Cortical Bone. Appl Spectrosc. 2017;71:2385-2394 pubmed publisher
    ..0% (PC5) to 48.5% (PC7), 31.4% (PC6), and 25.8% (PC7) of the variance in Kinit, Kgrow, and J-int, respectively...
  36. Lee S, Lee D, Lee M, Yoon J. Proprotein convertase 5/6a is associated with bone morphogenetic protein-2-induced squamous cell differentiation. Am J Respir Cell Mol Biol. 2015;52:749-61 pubmed publisher
    ..model of cultured human nasal epithelial cells (HNECs), we observed a significant increase in the expression of PC5/6A, a PC member, and bone morphogenetic protein-2 (BMP-2), a candidate substrate for PC5/6A...
  37. Bang S, Ryu Y, Chang S, Im C, Bae J, Gwak Y, et al. Attenuation of hypertension by C-fiber stimulation of the human median nerve and the concept-based novel device. Sci Rep. 2018;8:14967 pubmed publisher
    ..Experimental animal studies have shown that stimulation of the median nerve or PC6 acupoint over the wrist has effects on cardiovascular activities, including reductions in systolic and diastolic ..
  38. Jang C, Jung M, Sohn E, Kim M, Yoo H, Bae K, et al. The evaluation of changes in peripheral neuropathy and quality-of-life using low-frequency electrostimulation in patients treated with chemotherapy for breast cancer: a study protocol. Trials. 2018;19:526 pubmed publisher
    ..Electrostimulation will be administered on the unilateral PC6 acupoint. A numerical rating scale will be used to assess the overall intensity of CIPN symptoms...
  39. Cho J, Hyun S, Han J, Kim S, Shin D. Historical trend in heavy metal pollution in core sediments from the Masan Bay, Korea. Mar Pollut Bull. 2015;95:427-32 pubmed publisher
    ..The three short cores used for this study were collected from the catchment area (MS-PC5, 60cm length), the central part (MS-PC4, 40cm length) and the offshore (MS-PC2, 60cm length) of the Masan Bay, ..
  40. Setiadi A, Owen D, Tsang A, Milner R, Vercauteren S. The significance of peripheral blood minimal residual disease to predict early disease response in patients with B-cell acute lymphoblastic leukemia. Int J Lab Hematol. 2016;38:527-34 pubmed publisher
    ..BM MRD at diagnosis and day 29 of induction therapy was analyzed using the following antibody combinations: CD45-PC5/CD19-PC7/CD20-PE/CD10-ECD/CD38-FITC/CD13 + CD33-PE/CD10-ECD/CD34-FITC...
  41. Kucharska A, Gorska E, Stelmaszczyk Emmel A, Demkow U, Pyrżak B. Immunological Characteristics of Children with Hashimoto's Autoimmune Thyroiditis. Adv Exp Med Biol. 2015;833:47-53 pubmed publisher
    ..was evaluated using a Beckman Coulter flow cytometer with the following monoclonal antibodies: CD4-FITC, CD28-PC5, CD152-PE and CD8-FITC, CD28-PC5, CD152-PE...
  42. Zhang C, Guo L. Dalitong granule combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial. Chin J Integr Med. 2015;21:743-50 pubmed publisher
    ..6 g DG 3 times daily; the EA group was treated with puncture of points Zusanli (ST36), Zhongwan (CV12), Neiguan (PC6), Taichong (LR3) and Gongsun (SP4) twice daily; the combined group with above-mentioned DG and EA; and the control ..
  43. Jang D, Jung C, Kim K, Lee J. Electroacupuncture for abdominal pain relief in patients with acute pancreatitis: study protocol for a randomized controlled trial. Trials. 2018;19:279 pubmed publisher
    ..while distal EA includes 12 peripheral acupoints, Zhong Wan (CV12), Shang Wan (CV13), He Gu (LI4), Nei Guan (PC6), San Yin Jiao (SP6), Xuan Zhong (GB39), Zu San Li (ST36), and Shang Ju Xu (ST37)...
  44. Dingemann J, Plewig B, Baumann I, Plinkert P, Sertel S. Acupuncture in posttonsillectomy pain : A prospective, double-blinded, randomized, controlled trial. HNO. 2017;65:73-79 pubmed publisher
    ..after drug intake, the verum group also received acupuncture according to classical acupuncture rules (S34, S44 and PC5). The control group had acupuncture needles placed at nonspecific acupuncture points in the midaxillary line...
  45. Carter T, Kay D, Browne M, Liu A, Romitti P, Kuehn D, et al. Anorectal atresia and variants at predicted regulatory sites in candidate genes. Ann Hum Genet. 2013;77:31-46 pubmed publisher
    ..Variants predicted to affect transcription factor binding, splicing, and DNA methylation in WNT3A, PCSK5, TCF4, MKKS, GLI2, HOXD12, and BMP4 were associated with anorectal atresia based on a nominal P value < 0.05...
  46. Xie Y, Chai X, Wang Y, Gao Y, Ma J. Effect of electro-acupuncture stimulation of Ximen (PC4) and Neiguan (PC6) on remifentanil-induced breakthrough pain following thoracal esophagectomy. J Huazhong Univ Sci Technolog Med Sci. 2014;34:569-574 pubmed publisher
    ..groups: group A (control) receiving a general anesthesia only; group B (sham) given EA needles at PC4 (Ximen) and PC6 (Neiguan) but no stimulation; and group C (EAS) electrically given EAS of the ipsilateral PC4 and PC6 throughout ..
  47. Ji C, Song F, Huang G, Wang S, Liu H, Liu S, et al. The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury. Life Sci. 2018;211:51-62 pubmed publisher
    ..Gels were embedded at bilateral Neiguan (PC6) points of rats and their protective effects against myocardial I/R injury evaluated in terms of changes in ..
  48. Urroz P, Colagiuri B, Smith C, Yeung A, Cheema B. Effect of acupuncture and instruction on physiological recovery from maximal exercise: a balanced-placebo controlled trial. BMC Complement Altern Med. 2016;16:227 pubmed publisher
    ..Real acupuncture points included Neiguan (PC6), Zusanli (ST36), Lieque (LU7), and Tanzhang (REN17), while placebo acupuncture was delivered using the Park sham ..
  49. Madsen M, Knight S, Sweeney C, Factor R, Salama M, Stijleman I, et al. Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15. Cancer Epidemiol Biomarkers Prev. 2018;27:644-652 pubmed publisher
    ..explained the majority of the PAM50 expression variance: three captured intrinsic subtype, two were novel (PC3, PC5). All five replicated in 745 TCGA tumors...
  50. Watari R, Osis S, Phinyomark A, Ferber R. Runners with patellofemoral pain demonstrate sub-groups of pelvic acceleration profiles using hierarchical cluster analysis: an exploratory cross-sectional study. BMC Musculoskelet Disord. 2018;19:120 pubmed publisher
    ..Two pelvic acceleration components were different between clusters (PC1 and PC5; p < 0.001)...
  51. Boligon A, Silveira F, Silveira D, Dionello N, Santana M, Bignardi A, et al. Reduced-rank models of growth and reproductive traits in Nelore cattle. Theriogenology. 2015;83:1338-43 pubmed publisher
    ..additive direct (co)variance matrix, fitting the first one (PC1), two (PC2), three (PC3), four (PC4), and five (PC5) principal components. The model considering the first three principal components (PC3) provided the best fit...
  52. Lilge L, Terry M, Walter J, Pinnaduwage D, Glendon G, Hanna D, et al. Non-invasive optical spectroscopic monitoring of breast development during puberty. Breast Cancer Res. 2017;19:12 pubmed publisher
    ..Of the eight PCs, three component scores (PC4, PC5, and PC8) remained in the best-fitting model of BCRS, suggesting different levels of collagen in the breast tissue ..
  53. Kwan R, Leung M, Lai C. Acupressure for agitation in nursing home residents with dementia: study protocol for a randomized controlled trial. Trials. 2014;15:410 pubmed publisher
    ..acupressure group, participants receive acupressure at the Fengchi (GB20), Baihui (GV20), Shenmen (HT7), Niguan (PC6) and Yingtang (EX-HN3) acupoints...
  54. Kang J, Kim K, Lee J, Kim E, Kim T, Yoo K, et al. Predicting treatable traits for long-acting bronchodilators in patients with stable COPD. Int J Chron Obstruct Pulmon Dis. 2017;12:3557-3565 pubmed publisher
    ..volume in 1 second, bronchodilator reversibility (BDR) to salbutamol, expression of three genes (CLN8, PCSK5, and SKP2), and damage scores of four genes (EPG5, FNBP4, SCN10A, and SPTBN5..
  55. Ying Wang -, Zhao W, Li D, Xu Y, Li M, Chen J, et al. The Beneficial Effects of Electroacupuncture at PC6 Acupoints (Neiguan) on Myocardial Ischemia in ASIC3 -/- mice. J Acupunct Meridian Stud. 2018;11:88-96 pubmed publisher
    This study aims to investigate the possible mechanisms of electroacupuncture (EA) at PC6 to improve myocardial ischemia (MI) by regulating the cardiac transient outward potassium current channel (Ito)...
  56. Dingemann J, Plewig B, Baumann I, Plinkert P, Sertel S. [Acupuncture in posttonsillectomy pain : A prospective double-blind randomized controlled trial. German version]. HNO. 2017;65:643-650 pubmed publisher
    ..after drug intake, the verum group also received acupuncture according to classical acupuncture rules (S34, S44 and PC5). The control group had acupuncture needles placed at nonspecific acupuncture points in the midaxillary line...
  57. Han K, Kim S, Chung S. Effect of acupuncture on patients with insomnia: study protocol for a randomized controlled trial. Trials. 2014;15:403 pubmed publisher
    ..Five sham acupoints are used in the control group. In the experimental group, five real acupoints (PC6, SP6, HT7, KI6, and BL62) are used unilaterally in turn. Sham acupoints are over 1 cm away from each real acupoint...
  58. Kathy Lee S, Yoon K, Park J, Kim H, Woo J, Lee S, et al. Additional Effects of Back-Shu Electroacupuncture and Moxibustion in Cardioprotection of Rat Ischemia-Reperfusion Injury. Evid Based Complement Alternat Med. 2015;2015:625645 pubmed publisher
    Many preclinical studies show that electroacupuncture (EA) on PC6 and ST36 can reduce infarct size after ischemia-reperfusion (IR) injury. Yet studies to enhance the treatment effect size are limited...
  59. Jacquart A, Brayner R, El Hage Chahine J, Ha Duong N. Cd2+ and Pb2+ complexation by glutathione and the phytochelatins. Chem Biol Interact. 2017;267:2-10 pubmed publisher
    ..with Cd2+, PC2-Cd, PC2-Cd2, (PC2)3-Cd2, PC4-Cd, PC4-Cd2, PC6-Cd, (PC6)2-Cd3 and PC6-Cd3 complexes are detected...
  60. Zhao Z, Kim S, Zhao R, Wu Y, Zhang J, Liu H, et al. The tegmental-accumbal dopaminergic system mediates the anxiolytic effect of acupuncture during ethanol withdrawal. Neurosci Lett. 2015;597:143-8 pubmed publisher
    ..During EW, the rats were bilaterally treated with acupuncture at acupoints HT7 (Shenmen) or PC6 (Neiguan) or at a non-acupoint (tail) once daily for 1min over 3 days...
  61. Chen B, Hu S, Liu B, Zhao T, Li B, Liu Y, et al. Efficacy and safety of electroacupuncture with different acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial. Trials. 2015;16:212 pubmed publisher
    ..trial (RCT) with four parallel arms: a control group and three electroacupuncture groups (one with Neiguan (PC6), one with Zhongwan (CV12), and one with both PC6 and CV12)...
  62. Jiang W, Wei H, Guo Z, Ni Y, Yang H, Xie S. Effects of different-intensity laser acupuncture at two adjacent same-meridian acupoints on nitric oxide and soluble guanylate cyclase releases in human. Microcirculation. 2017;24: pubmed publisher
    ..Different intensities (12, 24, 48 mW) of infrared laser were used for irradiating Jianshi (PC5), Ximen (PC4) acupoints and nonacupoint for 20, 40 minutes, respectively...
  63. Li S, Zheng M, Wu W, Guo J, Ji F, Zheng Z. Effects of Electroacupuncture Administered 24hours Prior to Surgery on Postoperative Nausea and Vomiting and Pain in Patients Undergoing Gynecologic Laparoscopic Surgery: A Feasibility Study. Explore (NY). 2017;13:313-318 pubmed publisher
    ..The patients in the EA group received EA at bilateral neiguan (PC6) and zusanli (ST36) within 24hours prior to the surgery...
  64. Gao J, Zhao Y, Wang Y, Xin J, Cui J, Ma S, et al. Anti-arrhythmic effect of acupuncture pretreatment in the rats subjected to simulative global ischemia and reperfusion--involvement of intracellular Ca2+ and connexin 43. BMC Complement Altern Med. 2015;15:5 pubmed publisher
    ..For EA pretreatment, bilateral Neiguan acupoints (PC6) of the rats were stimulated for 30 min once a day in 3 consecutive days...
  65. Do H, Bruelle C, Pham D, Jauhiainen M, Eriksson O, Korhonen L, et al. Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth. J Neurochem. 2016;136:306-15 pubmed publisher
    ..Here, we show that nerve growth factor (NGF) increases LDLR levels in PC6.3 cells and in cultured septal neurons from embryonic rat brain...
  66. Mazda Y, Kikuchi T, Yoshimatsu A, Kato A, Nagashima S, Terui K. Acupuncture for reducing pruritus induced by intrathecal morphine at elective cesarean delivery: a placebo-controlled, randomized, double-blind trial. Int J Obstet Anesth. 2018;36:66-76 pubmed publisher
    ..certified acupuncturists inserted either indwelling press needles or sham needles, into Hegu (LI4), Neiguan (PC6), Quchi (LI11), and Zhigou (SJ6) on both arms the day before surgery...
  67. Susan Resiga D, Essalmani R, Hamelin J, Asselin M, Benjannet S, Chamberland A, et al. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. J Biol Chem. 2011;286:22785-94 pubmed publisher
    ..In vitro digestion of a 12-mer peptide encompassing the predicted cleavage site with furin, PACE4, PC5/6, and PC7, showed that furin cleaves the best, whereas PC7 is inactive on this peptide...
  68. Sathyamurthy M, Kim C, Bang Y, Kim Y, Jang J, Lee G. Characterization and expression of proprotein convertases in CHO cells: Efficient proteolytic maturation of human bone morphogenetic protein-7. Biotechnol Bioeng. 2015;112:560-8 pubmed publisher
    ..Analysis of the mRNA expression levels of four PCs (furin, PACE4, PC5/6, and PC7) revealed that only furin and PC7 genes are expressed in CHO-BMP-7 cells...
  69. Sui X, Liu X, Lin W, Wu Z, Yang L. Targeting of rice grassy stunt virus pc6 protein to plasmodesmata requires the ER-to-Golgi secretory pathway and an actin-myosin VIII motility system. Arch Virol. 2018;163:1317-1323 pubmed publisher
    The nonstructural protein pc6 encoded by rice grassy stunt virus (RGSV) plays a significant role in viral cell-to-cell movement, presumably by transport through plasmodesmata (PD)...
  70. Zhang B, Xu F, Hu P, Zhang M, Tong K, Ma G, et al. Needleless Transcutaneous Electrical Acustimulation: A Pilot Study Evaluating Improvement in Post-Operative Recovery. Am J Gastroenterol. 2018;113:1026-1035 pubmed publisher
    ..TEA was performed via acupoints ST36 and PC6 1?h twice daily from the postoperative day (POD) 1 to day 3. Sham-TEA was performed at non-acupoints...
  71. Zotelli V, Grillo C, de Sousa M. Nausea control by needling at acupuncture point Neiguan (PC6) during an intraoral impression-taking procedure. J Acupunct Meridian Stud. 2014;7:318-23 pubmed publisher
    The objective of this study was to evaluate the effectiveness of acupuncture point PC6 (Neiguan) in controlling nausea during intraoral impression taking. This study was conducted in Piracicaba, São Paulo, Brazil...
  72. Huang Y, Lu S, Hu C, Fu S, Shen W, Liu W, et al. Electro-acupuncture at Neiguan pretreatment alters genome-wide gene expressions and protects rat myocardium against ischemia-reperfusion. Molecules. 2014;19:16158-78 pubmed publisher
    ..genome-wide gene expressions and the cardioprotective effects of electro-acupuncture pretreatment at the PC6 Neiguan acupoint on myocardial ischemia reperfusion (I/R) injury...
  73. Ozkisacik S, Erdem A, Etensel B, Tataroglu C, Serter M, Yazici M. Short-interval postconditioning protects the bowel against ischaemia-reperfusion injury in rats. J Int Med Res. 2017;45:1036-1041 pubmed publisher
    ..sham (Sh), ischaemia + reperfusion (IR), ischaemia + postconditioning for 5 seconds (PC5), ischaemia + postconditioning for 10 seconds (PC10), and ischaemia + postconditioning ..
  74. Declercq J, Brouwers B, Pruniau V, Stijnen P, Tuand K, Meulemans S, et al. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. Biomed Res Int. 2015;2015:148651 pubmed publisher
    ..In a mouse model for HCC expression of Furin was not altered in the tumors, while those of PC7, PC5/6, and PACE4 significantly decreased, at least at some time points...
  75. Gouveia F, Oliveira C, Losa N. Acupuncture in the Management of Intraoperative Nausea and Vomiting. J Acupunct Meridian Stud. 2016;9:325-329 pubmed publisher
    ..Acupuncture at PC6 has demonstrated efficacy in randomized trials, although evidence regarding its efficacy in treating IONV and PONV ..
  76. Sun J, Li X, Yang C, Wang Y, Shi F, Gao Y, et al. Transcutaneous electrical acupuncture stimulation as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans. Acupunct Med. 2015;33:381-7 pubmed publisher
    ..4 days HDBR without countermeasures) and a TEAS treatment group (TEAS, n=8, 4 days HDBR with TEAS at Neiguan (PC6) for 30 min each day for 4 consecutive days during HDBR)...
  77. Heng S, Paule S, Li Y, Rombauts L, Vollenhoven B, Salamonsen L, et al. Posttranslational removal of α-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women. FASEB J. 2015;29:4011-22 pubmed publisher
    ..epithelium is a barrier for embryo attachment and that removal of α-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation) regulates receptivity...
  78. Noll E, Shodhan S, Madariaga M, Page C, Santangelo D, Guo X, et al. Randomized trial of acupressure to improve patient satisfaction and quality of recovery in hospitalized patients: study protocol for a randomized controlled trial. Trials. 2017;18:110 pubmed publisher
    ..parallel, superiority, blinded, randomized controlled trial will test the hypothesis that a combination of PC6, LI4 and HT7 acupressure is superior to sham or no intervention for improving postoperative quality of recovery in ..
  79. Paule S, Nebl T, Webb A, Vollenhoven B, Rombauts L, Nie G. Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation. Mol Hum Reprod. 2015;21:262-70 pubmed publisher
    ..Proprotein convertase 5/6 (referred to as PC6) is up-regulated in the human endometrium specifically at the time of epithelial receptivity...
  80. Liu J, Zhang F, Zhang A, Tong Q, Tung C, Wang W. New Class of Hydrido Iron(II) Compounds with cis-Reactive Sites: Combination of Iron and Diphosphinodithio Ligand. Chem Asian J. 2016;11:2271-7 pubmed publisher
    The cationic complex [Fe(P2 S2 )(NCMe)2 ](2+) (P2 S2 =(Ph2 PC6 H4 CH2 S)2 (C2 H4 ) ([1(NCMe)2 ](2+) )), with two MeCN ligands in a cis orientation, was synthesized and characterized...
  81. Cao H, Mok A, Miskie B, Hegele R. Single-nucleotide polymorphisms of the proprotein convertase subtilisin/ kexin type 5 (PCSK5) gene. J Hum Genet. 2001;46:730-2 pubmed
    The proprotein convertase. subtilisin/kexin type 5, or PCSK5, mediates post-translational endoproteolytic processing for several integrin alpha subunits...
  82. Kilpatrick L, Stephens A, Hardman B, Salamonsen L, Li Y, Stanton P, et al. Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment. J Proteome Res. 2009;8:4983-92 pubmed publisher
    Proprotein convertase 5/6 (PC6), a member of the proprotein convertase (PC) family, is a critical regulator in the uterus for embryo implantation...
  83. Hochstrasser R, Endler P, Klein S. Introduction of two novel devices for investigating the influence of non-mechanical components such as therapeutic qi in acupuncture. J Integr Med. 2013;11:168-74 pubmed publisher
    ..The Acuplicator was used to insert needles at Neiguan (PC6) on the right forearm of 23 volunteers. The insertion depth was measured using a depth gauge...
  84. Bardarov K, Naydenov M, Djingova R. HPLC-HRMS method for fast phytochelatins determination in plants. Application to analysis of Clinopodium vulgare L. Talanta. 2015;142:20-7 pubmed publisher
    ..A baseline separation of glutathione (GSH) and phytochelatins from 2 to 5 (PC2-PC5) for 3 min was achieved at conventional HPLC backpressure, with detection limits from 3 ppt (for GSH) to 2...
  85. Butte N, Liu Y, Zakeri I, Mohney R, Mehta N, Voruganti V, et al. Global metabolomic profiling targeting childhood obesity in the Hispanic population. Am J Clin Nutr. 2015;102:256-67 pubmed publisher
    ..Steroid derivatives were markedly higher in obese children as were markers of inflammation and oxidative stress. PC6 (BCAAs and aromatic AAs) and PC10 (asparagine, glycine, and serine) made the largest contributions to body mass ..
  86. Gao Y, Li C, Wang J, Tan L, Duanmu C, Jing X, et al. Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model. Purinergic Signal. 2017;13:215-225 pubmed publisher
    ..EA stimulation was applied to bilateral LI18, LI4-PC6, or ST36-GB34...
  87. Chen K, Lu Y, Chen J, Shi D, Huang Z, Zheng Y, et al. Transcutaneous electroacupuncture alleviates postoperative ileus after gastrectomy: A randomized clinical trial. World J Gastrointest Surg. 2018;10:13-20 pubmed publisher
    ..The patients in the TEA group received 1 h TEA on Neiguan (ST36) and Zusanli (PC6) twice daily in the morning and afternoon until they passed flatus...
  88. Fugere M, Limperis P, Beaulieu Audy V, Gagnon F, Lavigne P, Klarskov K, et al. Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains. J Biol Chem. 2002;277:7648-56 pubmed
    ..and short C-terminal prodomain peptides of each SPC on highly purified, soluble enzyme preparations of human SPC1, SPC6, and SPC7...
  89. Tran T, Kim M, Jang Y, Lee H, Nguyen H, Nguyen T, et al. Characterization and mechanisms of anti-influenza virus metabolites isolated from the Vietnamese medicinal plant Polygonum chinense. BMC Complement Altern Med. 2017;17:162 pubmed publisher
    ..5 μg/mL in a CPE inhibition assay. Among the eight pure metabolites isolated from P. chinense, ellagic acid (PC5), methyl gallate (PC7) and caffeic acid (PC8) significantly inhibited viral replication in a dose-dependent manner ..
  90. Miranda L, Wolf J, Pichuantes S, Duke R, Franzusoff A. Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes. Proc Natl Acad Sci U S A. 1996;93:7695-700 pubmed
    ..We have cloned novel members of the SPC family, known as the human PC6 genes. Two isoforms of the hPC6 protease are expressed in human T cells, hPC6A and the larger hPC6B...
  91. Yamamoto H, Ramos Molina B, Lick A, Prideaux M, Albornoz V, Bonewald L, et al. Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition. Bone. 2016;84:120-130 pubmed publisher
    ..In vitro, PC1/3 and PC2, but not furin, efficiently cleaved glycosylated FGF23; surprisingly, PC5/6 accomplished a small amount of conversion...
  92. Gao L, Chen B, Zhang Q, Zhao T, Li B, Sha T, et al. Acupuncture with different acupoint combinations for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial. BMC Complement Altern Med. 2016;16:441 pubmed
    ..Acupuncture group I and II will receive distal-proximal point association ("Neiguan (PC6) and Zhongwan (CV12)", and "Zusanli (ST36) and CV12", respectively); Acupuncture group III will receive local ..