Gene Symbol: PCM1
Description: pericentriolar material 1
Alias: PTC4, RET/PCM-1, pericentriolar material 1 protein, PCM-1, hPCM-1, pericentriolar material 1, PCM1
Species: human
Products:     PCM1

Top Publications

  1. Zhang Q, Yu D, Seo S, Stone E, Sheffield V. Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome. J Biol Chem. 2012;287:20625-35 pubmed publisher
    ..BBS1, BBS5, BBS8, and finally BBS4 are added to the BBSome core to form the complete BBSome. ..
  2. Kim J, Krishnaswami S, Gleeson J. CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium. Hum Mol Genet. 2008;17:3796-805 pubmed publisher
    ..Our results suggest that PCM-1 is a potential mediator that may link CEP290 with BBS proteins in common molecular pathways. ..
  3. Adelaide J, Perot C, Gelsi Boyer V, Pautas C, Murati A, Copie Bergman C, et al. A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma. Leukemia. 2006;20:536-7 pubmed
  4. Tang Z, Lin M, Stowe T, Chen S, Zhu M, Stearns T, et al. Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature. 2013;502:254-7 pubmed publisher
    ..This work reveals that removal of OFD1 by autophagy at centriolar satellites represents a general mechanism to promote ciliogenesis in mammalian cells. These findings define a newly recognized role of autophagy in organelle biogenesis. ..
  5. Kim K, Lee K, Rhee K. CEP90 is required for the assembly and centrosomal accumulation of centriolar satellites, which is essential for primary cilia formation. PLoS ONE. 2012;7:e48196 pubmed publisher
    ..Our results imply that the assembly and transport of centriolar satellites are critical steps for primary cilia formation and ciliary protein recruitment. ..
  6. Kodani A, Tonthat V, Wu B, Sutterlin C. Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment. Mol Biol Cell. 2010;21:3376-85 pubmed publisher
    ..We propose a model in which Par6? controls centrosome organization through its association with the dynactin subunit p150(Glued). ..
  7. Nachury M, Loktev A, Zhang Q, Westlake C, Peranen J, Merdes A, et al. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell. 2007;129:1201-13 pubmed
    ..Conversely, preventing Rab8(GTP) production blocks ciliation in cells and yields characteristic BBS phenotypes in zebrafish. Our data reveal that BBS may be caused by defects in vesicular transport to the cilium. ..
  8. Balczon R, Bao L, Zimmer W. PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. J Cell Biol. 1994;124:783-93 pubmed
    ..These results demonstrate that the pericentriolar material is a dynamic substance whose composition can fluctuate during the cell cycle. ..
  9. Wang G, Chen Q, Zhang X, Zhang B, Zhuo X, Liu J, et al. PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. J Cell Sci. 2013;126:1355-65 pubmed publisher
    ..Furthermore, we showed that pericentriolar material 1 (PCM1) acts upstream of Plk1 and recruits the kinase to pericentriolar matrix (PCM) in a dynein-dynactin complex-..

More Information


  1. Staples C, Myers K, Beveridge R, Patil A, Lee A, Swanton C, et al. The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci. 2012;125:4770-9 pubmed publisher
    ..Cep131 is recruited to centriolar satellites by PCM1, and localised to the centriolar core region by both pericentrin and Cep290...
  2. Akimov V, Rigbolt K, Nielsen M, Blagoev B. Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics. Mol Biosyst. 2011;7:3223-33 pubmed publisher
    ..Furthermore, we found two centrosomal proteins, PCM1 and Azi1, to form a multi-protein complex with the ubiquitin E3 ligases MIB1 and WWP2 downstream of the EGFR, ..
  3. Dammermann A, Merdes A. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. J Cell Biol. 2002;159:255-66 pubmed
  4. Li Q, Hansen D, Killilea A, Joshi H, Palazzo R, Balczon R. Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1. J Cell Sci. 2001;114:797-809 pubmed
    ..This observation may help to explain the generation of anti-centrosome autoantibodies in certain autoimmune patients and may be important for centrosome function. ..
  5. Hames R, Crookes R, Straatman K, Merdes A, Hayes M, Faragher A, et al. Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. Mol Biol Cell. 2005;16:1711-24 pubmed
    ..Together, these data highlight multiple processes involved in regulating the abundance of Nek2 kinase at the centrosome including microtubule binding, the centriolar satellite component PCM-1, and localized protein degradation. ..
  6. Kim J, Badano J, Sibold S, Esmail M, Hill J, Hoskins B, et al. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet. 2004;36:462-70 pubmed
    ..as an adaptor of the p150(glued) subunit of the dynein transport machinery to recruit PCM1 (pericentriolar material 1 protein) and its associated cargo to the satellites...
  7. Ge X, Frank C, Calderon de Anda F, Tsai L. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron. 2010;65:191-203 pubmed publisher
    ..that trafficking of pericentriolar satellites requires the interaction between Hook3 and Pericentriolar Material 1 (PCM1). Hook3, previously shown to link the centrosome and the nucleus in C...
  8. Villumsen B, Danielsen J, Povlsen L, Sylvestersen K, Merdes A, Beli P, et al. A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis. EMBO J. 2013;32:3029-40 pubmed publisher
    ..heat shock, and transcription blocks, invoking acute and selective displacement of the factors AZI1/CEP131, PCM1, and CEP290 from this compartment triggered by activation of the stress-responsive kinase p38/MAPK14...
  9. Srsen V, Gnadt N, Dammermann A, Merdes A. Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. J Cell Biol. 2006;174:625-30 pubmed
    ..Inhibition of p38 mitogen-activated protein kinase rescued cell cycle activity after centrosome protein depletion, indicating that p53 is activated by the p38 stress pathway. ..
  10. Choi Y, Lee S, Lee W, Jeon H, Lee E, Lee H, et al. RACK1 is a candidate gene associated with the prognosis of patients with early stage non-small cell lung cancer. Oncotarget. 2015;6:4451-66 pubmed
    ..Among those, five SNPs (RACK1 rs1279736C>A and rs3756585T>G, C3 rs2287845T>C, PCAF rs17006625A>G, and PCM1 rs17691523C>G) were found to be significantly associated with survival in the same direction as the discovery ..
  11. Hoang Minh L, Deleyrolle L, Nakamura N, Parker A, Martuscello R, Reynolds B, et al. PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide. Transl Oncol. 2016;9:392-402 pubmed publisher
    ..In this study, we characterize the role of pericentriolar material 1 (PCM1), a component of centriolar satellites surrounding centrosomes, in GBM cell proliferation and sensitivity to ..
  12. Tang G, Sydney Sir Philip J, Weinberg O, Tam W, Sadigh S, Lake J, et al. Hematopoietic neoplasms with 9p24/JAK2 rearrangement: a multicenter study. Mod Pathol. 2019;32:490-498 pubmed publisher
    ..to examine hematopoietic neoplasms with 9p24/JAK2 rearrangement including neoplasms associated with t(8;9)(p22;p24)/PCM1-JAK2 fusion neoplasm as well as cases with translocations involving 9p24/JAK2 and other partner genes...
  13. Sacristán Reviriego A, Martín H, Molina M. Identification of putative negative regulators of yeast signaling through a screening for protein phosphatases acting on cell wall integrity and mating MAPK pathways. Fungal Genet Biol. 2015;77:1-11 pubmed publisher
    ..Moreover, we have found that Ptc2 and Ptc4 bind to the CWI MAPK Slt2...
  14. Pettersson M, Viljakainen H, Loid P, Mustila T, Pekkinen M, Armenio M, et al. Copy Number Variants Are Enriched in Individuals With Early-Onset Obesity and Highlight Novel Pathogenic Pathways. J Clin Endocrinol Metab. 2017;102:3029-3039 pubmed publisher
    ..Expression analysis of 37 candidate genes showed discordant expression for 10 genes (PCM1, EFEMP1, MAMLD1, ACP6, BAZ2B, SORBS1, KLF15, MACROD2, ATR, and MBD5)...
  15. Thapa S, Pattathil S, Hahn M, Jacques M, Gilbertson R, Coaker G. Genomic Analysis of Clavibacter michiganensis Reveals Insight Into Virulence Strategies and Genetic Diversity of a Gram-Positive Bacterial Pathogen. Mol Plant Microbe Interact. 2017;30:786-802 pubmed publisher
    ..Plasmid profiles of the California strains were variable and supported the essential role of the pCM1-like plasmid and the CelA cellulase in virulence, whereas the absence of the pCM2-like plasmid in some pathogenic C...
  16. Hall E, Keighren M, Ford M, Davey T, Jarman A, Smith L, et al. Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. PLoS Genet. 2013;9:e1003928 pubmed publisher
    ..Our study highlights the importance of both acute removal of a protein, in addition to mouse knock-out studies, when functionally characterising candidates for human disease. ..
  17. Lee J, Stearns T. FOP is a centriolar satellite protein involved in ciliogenesis. PLoS ONE. 2013;8:e58589 pubmed publisher
    ..We find that FOP partially co-localizes with the satellite component PCM1 in a cell cycle-dependent manner, similarly to the satellite and cilium component BBS4...
  18. Porpora M, Sauchella S, Rinaldi L, Delle Donne R, Sepe M, Torres Quesada O, et al. Counterregulation of cAMP-directed kinase activities controls ciliogenesis. Nat Commun. 2018;9:1224 pubmed publisher
    ..At centriolar satellites, we identify a multimeric complex nucleated by PCM1 that includes two kinases, NEK10 and PKA, and the E3 ubiquitin ligase CHIP...
  19. Rampino A, Walker R, Torrance H, Anderson S, Fazio L, Di Giorgio A, et al. Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. PLoS ONE. 2014;9:e99892 pubmed publisher
    ..Finally, the expression levels of DISC1, AKAP9, FEZ1, NDEL1 and PCM1 were compared between 63 controls and 69 schizophrenic subjects...
  20. Hsu T, Lin S, Lu P, Chang W, Hung C, Yeh Y, et al. MMP7-mediated cleavage of nucleolin at Asp255 induces MMP9 expression to promote tumor malignancy. Oncogene. 2015;34:826-37 pubmed publisher
    ..anaplastic lymphoma kinase (ALK), HIF1a and CBLB, and decreased the expression of tumor suppressors including BRD4, PCM1, TFG and KLF6 by modulating mRNA stability through binding to the 3'-untranslated regions of their transcripts, ..
  21. Schwaab J, Knut M, Haferlach C, Metzgeroth G, Horny H, Chase A, et al. Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes. Ann Hematol. 2015;94:233-8 pubmed publisher
    ..g., t(8;9)(p22;p24) with a PCM1-JAK2 and t(9;22)(p24;q11) with a BCR-JAK2 fusion gene, respectively...
  22. Bain B, Ahmad S. Should myeloid and lymphoid neoplasms with PCM1-JAK2 and other rearrangements of JAK2 be recognized as specific entities?. Br J Haematol. 2014;166:809-17 pubmed publisher
    ..On the basis of this analysis, it is suggested that lymphoid and myeloid neoplasms associated with t(8;9)(p22;p24); PCM1-JAK2 fusion should be recognized as an entity...
  23. Zoubovsky S, Oh E, Cash Padgett T, Johnson A, Hou Z, Mori S, et al. Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1). Neurosci Res. 2015;98:45-9 pubmed publisher
    ..Here, we show that mice haploinsufficient for Pericentriolar material 1 (Pcm1(+/-)), which encodes a component of the PCM found to bear rare loss of function mutations in patients with ..
  24. Richardson G. Simultaneous Assessment of Cardiomyocyte DNA Synthesis and Ploidy: A Method to Assist Quantification of Cardiomyocyte Regeneration and Turnover. J Vis Exp. 2016;: pubmed publisher
    ..as a result of DNA replication and cardiomyocyte nuclei identified by utilizing nuclei isolation and subsequent PCM1 immunolabeling...
  25. Zhang W, Kim P, Chen Z, Lokman H, Qiu L, Zhang K, et al. MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex. elife. 2016;5: pubmed publisher
    ..microRNA (miR)-128 regulates the proliferation and differentiation of NPCs by repressing pericentriolar material 1 (PCM1)...
  26. Sandgren J, Holm S, Marino A, Asmundsson J, Grillner P, Nister M, et al. Whole Exome- and mRNA-Sequencing of an AT/RT Case Reveals Few Somatic Mutations and Several Deregulated Signalling Pathways in the Context of SMARCB1 Deficiency. Biomed Res Int. 2015;2015:862039 pubmed publisher
    ..genes affected by predicted damaging germline variants that were expressed were detected (KDM5C, NUMA1, and PCM1)...
  27. Tozer S, Baek C, Fischer E, Goïame R, Morin X. Differential Routing of Mindbomb1 via Centriolar Satellites Regulates Asymmetric Divisions of Neural Progenitors. Neuron. 2017;93:542-551.e4 pubmed publisher
    ..we show that the Notch pathway regulator Mindbomb1 co-localizes asymmetrically with centriolar satellite proteins PCM1 and AZI1 at the daughter centriole in interphase...
  28. Brzozowska E, Koba M, Smietana M, Górska S, Janik M, Gamian A, et al. Label-free Gram-negative bacteria detection using bacteriophage-adhesin-coated long-period gratings. Biomed Opt Express. 2016;7:829-40 pubmed publisher
    ..coli O111 (PCM418), Klebsiella pneumoniae O1 (PCM1) and Yersinia enterocolitica O1 (PCM1879)...
  29. Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, et al. WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. J Cell Sci. 2016;129:621-36 pubmed publisher
    ..We show that WDR8 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component Cep135...
  30. Farina F, Gaillard J, Guérin C, Couté Y, Sillibourne J, Blanchoin L, et al. The centrosome is an actin-organizing centre. Nat Cell Biol. 2016;18:65-75 pubmed publisher
    ..Pericentriolar material 1 (PCM1) seemed to modulate the centrosomal actin network by regulating Arp2/3 complex and WASH recruitment to the ..
  31. Hori A, Barnouin K, Snijders A, Toda T. A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. EMBO Rep. 2016;17:326-37 pubmed publisher
    ..Plk4 interacts with the satellite component PCM1, and its kinase activity is required for phosphorylation of the conserved S372...
  32. Bacher U, Reiter A, Haferlach T, Mueller L, Schnittger S, Kern W, et al. A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia. Haematologica. 2006;91:817-20 pubmed
    ..RT-PCR confirmed a PCM1-JAK2 fusion underlying the t(8;9). FISH analysis suggested a rearrangement involving PDGFRA in the ins(9;4)...
  33. Wang Q, Tang Y, Xu Y, Xu S, Jiang Y, Dong Q, et al. The X-linked deubiquitinase USP9X is an integral component of centrosome. J Biol Chem. 2017;292:12874-12884 pubmed publisher
    ..Interestingly, we showed that USP9X promotes stabilization of centrosome proteins PCM1 and CEP55 through its catalytic activity...
  34. Gurling H, Critchley H, Datta S, McQuillin A, Blaveri E, Thirumalai S, et al. Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Arch Gen Psychiatry. 2006;63:844-54 pubmed
    ..Variation in brain morphology associated with pericentriolar material 1 (PCM1) alleles was examined using voxel-based morphometry and statistical parametric mapping with magnetic resonance ..
  35. Ehrentraut S, Nagel S, Scherr M, Schneider B, Quentmeier H, Geffers R, et al. t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5. PLoS ONE. 2013;8:e53767 pubmed publisher
    ..Here we describe the genomic, transcriptional and signalling characteristics of PCM1-JAK2 formed by t(8;9)(p22;p24) in a trio of cell lines established at indolent (MAC-1) and aggressive (MAC-2A/2B) ..
  36. Reiter A, Walz C, Watmore A, Schoch C, Blau I, Schlegelberger B, et al. The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer Res. 2005;65:2662-7 pubmed
    ..Rapid amplification of cDNA ends-PCR identified the 8p22 partner gene as human autoantigen pericentriolar material (PCM1), a gene encoding a large centrosomal protein with multiple coiled-coil domains...
  37. Greer Y, Westlake C, Gao B, Bharti K, Shiba Y, Xavier C, et al. Casein kinase 1? functions at the centrosome and Golgi to promote ciliogenesis. Mol Biol Cell. 2014;25:1629-40 pubmed publisher
  38. Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, et al. No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. Schizophr Res. 2011;129:80-4 pubmed publisher
    ..The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton...
  39. Joachim J, Razi M, Judith D, Wirth M, Calamita E, Encheva V, et al. Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy. Curr Biol. 2017;27:2123-2136.e7 pubmed publisher
    ..We show that the centriolar satellite protein PCM1 regulates the recruitment of GABARAP to the pericentriolar material...
  40. Hwang I, Oh E, Kim D, Oh C. Multiple plasmid-borne virulence genes of Clavibacter michiganensis ssp. capsici critical for disease development in pepper. New Phytol. 2017;: pubmed publisher
    ..The C. michiganensis ssp. capsici type strain PF008 carries one chromosome (3.056 Mb) and two plasmids (39 kb pCM1Cmc and 145 kb pCM2Cmc )...
  41. Sakamoto S, Takaki M, Okahisa Y, Mizuki Y, Kodama M, Ujike H, et al. Four polymorphisms of the pericentriolar material 1 (PCM1) gene are not associated with schizophrenia in a Japanese population. Psychiatry Res. 2014;216:288-9 pubmed publisher
  42. Kumar S, Connor J, Dodds R, Halsey W, Van Horn M, Mao J, et al. Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. Osteoarthritis Cartilage. 2001;9:641-53 pubmed
    ..Further analysis of genes identified from these libraries may provide molecular targets for diagnosis and/or treatment of osteoarthritis (OA). ..
  43. Ansley S, Badano J, Blacque O, Hill J, Hoskins B, Leitch C, et al. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature. 2003;425:628-33 pubmed
    ..In cells, BBS8 localizes to centrosomes and basal bodies and interacts with PCM1, a protein probably involved in ciliogenesis...
  44. Sillibourne J, Hurbain I, Grand Perret T, Goud B, Tran P, Bornens M. Primary ciliogenesis requires the distal appendage component Cep123. Biol Open. 2013;2:535-45 pubmed publisher
    ..Together, the data implicate Cep123 as a new player in the primary ciliogenesis pathway and expand upon the role of the distal appendages in this process. ..
  45. Staples C, Myers K, Beveridge R, Patil A, Howard A, Barone G, et al. Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. J Cell Sci. 2014;127:2910-9 pubmed publisher
    ..We establish that Ccdc13 is a newly identified centriolar satellite protein that interacts with PCM1, Cep290 and pericentrin and prevents the accumulation of DNA damage during mitotic transit...
  46. Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, et al. DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. J Biol Chem. 2017;292:1351-1360 pubmed publisher
    ..Here we demonstrate that the centrosome protein Dzip1 mediates the assembly of the BBSome-Dzip1-PCM1 complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome...
  47. Eastwood S, Walker M, Hyde T, Kleinman J, Harrison P. The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain. Hum Mol Genet. 2010;19:2487-96 pubmed publisher
    ..that one DISC1 variant, Leu607Phe, influenced the extent of centrosomal localization of pericentriolar material 1 (PCM1) in SH-SY5Y cells...
  48. Firat Karalar E, Santé J, Elliott S, Stearns T. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. J Cell Sci. 2014;127:4128-33 pubmed publisher
    ..We examined the highly conserved protein CCDC113 further and found that it is a component of centriolar satellites, is in a complex with the satellite proteins HAP1 and PCM1, and functions in primary cilium formation.
  49. Bousquet M, Quelen C, De Mas V, Duchayne E, Roquefeuil B, Delsol G, et al. The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. Oncogene. 2005;24:7248-52 pubmed
    ..The locus at 8p22 contains different candidate genes including the pericentriolar material 1 gene (PCM1), already implicated in reciprocal translocations...
  50. Chung A, Hou Y, Ohgami R, Von Gehr A, Fisk D, Roskin K, et al. A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia. Cancer Genet. 2017;216-217:10-15 pubmed publisher
    ..with FLT3 fusion genes exhibit similar clinicopathologic features to, and should be included in, the WHO category of "Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2."
  51. Conkar D, Culfa E, Odabasi E, Rauniyar N, Yates J, Firat Karalar E. The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking. J Cell Sci. 2017;130:1450-1462 pubmed publisher
    ..satellite proteins, and co-immunoprecipitation experiments revealed interactions between CCDC66, CEP290 and PCM1. Ciliogenesis, ciliary recruitment of BBS4 and centriolar satellite organization are impaired in cells depleted for ..
  52. Gimpel P, Lee Y, Sobota R, Calvi A, Koullourou V, Patel R, et al. Nesprin-1?-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells. Curr Biol. 2017;27:2999-3009.e9 pubmed publisher
    ..The relocalization of centrosomal proteins, including Pericentrin, Pcm1, and ?-tubulin, depends on Nesprin-1, an outer nuclear membrane (ONM) protein that connects the nucleus to the ..
  53. Corvi R, Berger N, Balczon R, Romeo G. RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma. Oncogene. 2000;19:4236-42 pubmed
    ..However, heterozygosity is retained for seven microsatellite markers in the 8p21-22 region, suggesting that the non-rearranged PCM-1 allele is not lost and that the translocation is balanced. Oncogene (2000) 19, 4236 - 4242 ..
  54. Eastwood S, Hodgkinson C, Harrison P. DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release. Mol Psychiatry. 2009;14:556-7 pubmed publisher
  55. Oberley M, Denton C, Ji J, Hiemenz M, Bhojwani D, Ostrow D, et al. A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia. Cancer Genet. 2017;216-217:91-99 pubmed publisher
    ..group called "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 or with PCM1-JAK2"...
  56. Datta S, McQuillin A, Rizig M, Blaveri E, Thirumalai S, Kalsi G, et al. A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia. Mol Psychiatry. 2010;15:615-28 pubmed publisher
    Markers at the pericentriolar material 1 gene (PCM1) have shown genetic association with schizophrenia in both a University College London (UCL) and a USA-based case-control sample...
  57. Hori A, Ikebe C, Tada M, Toda T. Msd1/SSX2IP-dependent microtubule anchorage ensures spindle orientation and primary cilia formation. EMBO Rep. 2014;15:175-84 pubmed publisher
    ..We propose that the Msd1 family comprises conserved microtubule-anchoring proteins. ..
  58. Huang K, Chase A, Cross N, Reiter A, Li T, Wang T, et al. Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia. Int J Hematol. 2008;88:197-201 pubmed publisher
    The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was recently characterized in diverse hematological malignancies...
  59. Murati A, Gelsi Boyer V, Adelaide J, Perot C, Talmant P, Giraudier S, et al. PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation. Leukemia. 2005;19:1692-6 pubmed
  60. Chen X, Paranjape T, Stahlhut C, McVeigh T, Keane F, Nallur S, et al. Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer. Oncogene. 2015;34:2125-37 pubmed publisher
    ..single-nucleotide polymorphisms in the 3'UTR of the vascular endothelial growth factor receptor/FLT1, E2F2 and PCM1 oncogenes were highly enriched in ovarian cancer patients compared with the 1000 Genome Project...
  61. Kodani A, Yu T, Johnson J, Jayaraman D, Johnson T, Al Gazali L, et al. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. elife. 2015;4: pubmed publisher
    ..Thus, centriolar satellites build a MCPH complex critical for human neurodevelopment that promotes CDK2 centrosomal localization and centriole duplication. ..
  62. Oeffner F, Moch C, Neundorf A, Hofmann J, Koch M, Grzeschik K. Novel interaction partners of Bardet-Biedl syndrome proteins. Cell Motil Cytoskeleton. 2008;65:143-55 pubmed
    ..Our work provides new insights into the understanding of BBS interactions and thus their biological function. ..
  63. Kim S, Kim S, Kim S, Rhee K. NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells. J Cell Sci. 2011;124:3760-70 pubmed publisher
    ..Our study revealed that NEK7 activity is required for centrosome cycle progression not only at M phase, but also at G1 phase. ..
  64. Joachim J, Tooze S. Centrosome to autophagosome signaling: Specific GABARAP regulation by centriolar satellites. Autophagy. 2017;:1-2 pubmed publisher
    ..To address this, we have shown that the archetypal centriolar satellite protein PCM1 regulates recruitment of GABARAP to the centrosome...
  65. Moens L, Ceulemans S, Alaerts M, Van Den Bossche M, Lenaerts A, De Zutter S, et al. PCM1 and schizophrenia: a replication study in the Northern Swedish population. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1240-3 pubmed publisher
    ..2006; Datta et al., 2008. Mol Psychiatry] described an association between polymorphisms in the PCM1 gene and SZ in a UK/Scottish population...
  66. Pils D, Horak P, Gleiss A, Sax C, Fabjani G, Moebus V, et al. Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival. Cancer. 2005;104:2417-29 pubmed
    ..the authors selected the eight most noteworthy genes from 8p22 (DLC1, N33, ZDHHC2, FLJ32642, PDGFRL, MTSG1, PCM1, and EFA6R) for a detailed expression analysis in 58 primary ovarian carcinoma tissues and in 38 ovarian cancer ..
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    ..These findings associate AZI1 with the BBS pathway. Our findings provide further insight into the regulation of BBSome ciliary trafficking and identify AZI1 as a novel BBS candidate gene. ..
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    ..Moreover, Nudel seems to tether dynactin and dynein to the mother centriole for MT anchoring. ..
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    ..These findings provide a mechanistic link between the RNF168/USP10 axis and TOP2α ubiquitylation and function, and suggest a role for RNF168 in the response to anti-cancer chemotherapeutics that target TOP2. ..
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    ..Thus, HAP1 and huntingtin may play a role in vesicle trafficking within the cell and disruption of this function could contribute to the neuronal dysfunction and death seen in HD. ..
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    ..Our findings reveal the molecular mechanism underlying dynamic CS remodelling to modulate centrosome functions on cell stress. ..
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    ..Collectively, these results identify the interaction between Mib1 and Plk4 as a new and important element in the control of centriole homeostasis. ..
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    ..WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1)...
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    ..interfering RNA strategy, we found that Hook2 interacts with and stabilizes pericentriolar material protein 1 (PCM1), which was reported to be essential for the recruitment of Rab8a, a GTPase that is believed to be crucial for ..
  76. Armes J, Hammet F, De Silva M, Ciciulla J, Ramus S, Soo W, et al. Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers. Oncogene. 2004;23:5697-702 pubmed
    ..b>PCM1, which encodes a centrosomal protein, and DUSP4/MKP-2, which encodes a MAP kinase phosphatase, both showed frequent ..
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    ..To show that pericentriolar material 1 protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1 (DISC1) and Bardet-Biedl ..
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    To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites...