PCLAF

Summary

Gene Symbol: PCLAF
Description: PCNA clamp associated factor
Alias: KIAA0101, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF, PCNA-associated factor, HCV NS5A-transactivated protein 9, PCNA-associated factor of 15 kDa, hepatitis C virus NS5A-transactivated protein 9, overexpressed in anaplastic thyroid carcinoma 1
Species: human
Products:     PCLAF

Top Publications

  1. Li K, Ma Q, Shi L, Dang C, Hong Y, Wang Q, et al. NS5ATP9 gene regulated by NF-kappaB signal pathway. Arch Biochem Biophys. 2008;479:15-9 pubmed publisher
    NS5ATP9 was previously identified as p15 PAF [proliferating cell nuclear antigen (PCNA)-associated factor] to bind with PCNA. We earlier identified the promoter region of NS5ATP9 and found NS5ATP9 is a NS5A up-regulation gene...
  2. Liu L, Chen X, Xie S, Zhang C, Qiu Z, Zhu F. Variant 1 of KIAA0101, overexpressed in hepatocellular carcinoma, prevents doxorubicin-induced apoptosis by inhibiting p53 activation. Hepatology. 2012;56:1760-9 pubmed publisher
    b>KIAA0101 overexpression was detected in numerous malignant solid tumors and involved in tumor progression; however, the correlation between KIAA0101 expression level and human hepatocellular carcinoma (HCC) was controversial...
  3. Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, et al. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. Oncogene. 2004;23:7734-45 pubmed
  4. Mizutani K, Onda M, Asaka S, Akaishi J, Miyamoto S, Yoshida A, et al. Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma. Cancer. 2005;103:1785-90 pubmed
    ..and anonymous genes and investigated a novel gene, named the overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) gene...
  5. Yuan R, Jeng Y, Pan H, Hu F, Lai P, Lee P, et al. Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma. Clin Cancer Res. 2007;13:5368-76 pubmed
    b>KIAA0101 is a proliferating cell nuclear antigen-associated factor and involved in cell proliferation. This study is to elucidate its role in the progression, early tumor recurrence (ETR), and prognosis of hepatocellular carcinoma (HCC)...
  6. Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, et al. p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. Oncogene. 2001;20:484-9 pubmed
    ..A novel 15 kD protein, p15(PAF), was identified as a PCNA-associated factor in a yeast two-hybrid screen using PCNA as the bait...
  7. Emanuele M, Ciccia A, Elia A, Elledge S. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Proc Natl Acad Sci U S A. 2011;108:9845-50 pubmed publisher
    ..We have identified an APC/C substrate and cell cycle-regulated protein, KIAA0101/PAF15...
  8. Kais Z, Barsky S, Mathsyaraja H, Zha A, Ransburgh D, He G, et al. KIAA0101 interacts with BRCA1 and regulates centrosome number. Mol Cancer Res. 2011;9:1091-9 pubmed publisher
    ..in the pathogenesis of breast cancer, we used an informatics approach and found a candidate BRCA interactor, KIAA0101, to function like BRCA1 in exerting a powerful control over centrosome number...
  9. Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts J, Bowles J, Adolphe C, et al. The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Exp Cell Res. 2006;312:73-85 pubmed
    The KIAA0101/p15(PAF)/OEATC-1 protein was initially isolated in a yeast two-hybrid screen for proliferating cell nuclear antigen (PCNA) binding partners, and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF)...

More Information

Publications40

  1. Guo M, Li J, Wan D, Gu J. KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma. BMC Cancer. 2006;6:109 pubmed
    Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver...
  2. Shi L, Zhang S, Li K, Hong Y, Wang Q, Li Y, et al. NS5ATP9, a gene up-regulated by HCV NS5A protein. Cancer Lett. 2008;259:192-7 pubmed
    ..b>NS5ATP9 was identified as a NS5A trans-activated protein in suppression subtractive hybridization (SSH), and the ..
  3. Turchi L, Fareh M, Aberdam E, Kitajima S, Simpson F, Wicking C, et al. ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress. Cell Death Differ. 2009;16:728-37 pubmed publisher
    ..We provide evidence that ATF3 directly regulates the proliferating cell nuclear antigen (PCNA)-associated factor KIAA0101/p15(PAF)...
  4. Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kaji M. Overexpression of KIAA0101 predicts poor prognosis in primary lung cancer patients. Lung Cancer. 2012;75:110-8 pubmed publisher
    High expression of KIAA0101 (p15(PAF)/OEATC-1) which contains a proliferating cell nuclear antigen (PCNA)-binding motif, a key factor in DNA repair and/or apoptosis and cell cycle regulation, has been observed in a variety of human ..
  5. Jain M, Zhang L, Patterson E, Kebebew E. KIAA0101 is overexpressed, and promotes growth and invasion in adrenal cancer. PLoS ONE. 2011;6:e26866 pubmed publisher
    b>KIAA0101 is a proliferating cell nuclear antigen-associated factor that is overexpressed in some human malignancies. Adrenocortical neoplasm is one of the most common human neoplasms for which the molecular causes are poorly understood...
  6. Zhu K, Diao D, Dang C, Shi L, Wang J, Yan R, et al. Elevated KIAA0101 expression is a marker of recurrence in human gastric cancer. Cancer Sci. 2013;104:353-9 pubmed publisher
    ..The purpose of the present study was to investigate a factor related to recurrence. Expression of KIAA0101 was assessed in 61 paired human primary GC and non-cancerous gastric tissue using immunohistochemistry...
  7. Chang C, Feng M, Chen Y, Yuan R, Jeng Y. p15(PAF) is an Rb/E2F-regulated S-phase protein essential for DNA synthesis and cell cycle progression. PLoS ONE. 2013;8:e61196 pubmed publisher
    The p15(PAF)/KIAA0101 protein is a proliferating cell nuclear antigen (PCNA)-associated protein overexpressed in multiple types of cancer...
  8. Han J, Liu T, Huen M, Hu L, Chen Z, Huang J. SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. J Cell Biol. 2014;205:811-27 pubmed publisher
    ..Collectively, our results provide evidence that the RAD18 E3 ligase requires an accessory protein for binding to its substrate PCNA. ..
  9. Yan R, Zhu K, Dang C, Lan K, Wang H, Yuan D, et al. Paf15 expression correlates with rectal cancer prognosis, cell proliferation and radiation response. Oncotarget. 2016;7:38750-38761 pubmed publisher
    b>Paf15, which participates in DNA repair, is overexpressed in numerous solid tumors. Blocking of Paf15 inhibits the growth of many types of cancer cells; while simultaneously enhancing cellular sensitivity to UV radiation...
  10. Liu L, Liu Y, Chen X, Wang M, Zhou Y, Zhou P, et al. Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma. Oncotarget. 2017;8:43990-44003 pubmed publisher
    ..Our previous work demonstrates that oncogenic KIAA0101 transcript variant (tv) 1 promotes HCC development and might be a HCC therapeutic target...
  11. Jung H, Jun S, Lee M, Kim H, Wang X, Ji H, et al. PAF and EZH2 induce Wnt/?-catenin signaling hyperactivation. Mol Cell. 2013;52:193-205 pubmed publisher
    ..Here, we identify a function of PAF, a component of translesion DNA synthesis, in modulating Wnt signaling...
  12. Ji W, Chen J, Mi Y, Wang G, Xu X, Wang W. Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway. Int J Oncol. 2016;49:181-8 pubmed publisher
    Platelet-activating factor (PAF) and its receptor (PAFR), have been reported to participate in many cellular processes of cancer. However, little is known about their function in prostate cancer...
  13. Quan M, Liu S, Li G, Wang Q, Zhang J, Zhang M, et al. A functional role for NS5ATP9 in the induction of HCV NS5A-mediated autophagy. J Viral Hepat. 2014;21:405-15 pubmed publisher
    ..To obtain new insights into HCV-regulated autophagy, NS5ATP9 was overexpressed in HepG2 and L02 cells, resulting in up-regulation of endogenous Beclin 1 mRNA and protein ..
  14. Fan S, Li X, Tie L, Pan Y, Li X. KIAA0101 is associated with human renal cell carcinoma proliferation and migration induced by erythropoietin. Oncotarget. 2016;7:13520-37 pubmed publisher
    ..proteomics expression profiling suggested that exogenous EPO stimulated RCC progression via up-regulation of KIAA0101 expression. Loss of KIAA0101 impeded the undesirable propensity of EPO in RCC...
  15. Liu C, Liu H, Wang X, Xinbo S. Clinical significance and expression of PAF and TNF-alpha in seminal plasma of leukocytospermic patients. Mediators Inflamm. 2012;2012:639735 pubmed publisher
    Discuss the changes and roles of PAF in the reproductive tract infection by observing the expression of platelet activating factor (PAF) and tumor necrosis factor ? (TNF-?) in seminal plasma of patients with leukocytospermia...
  16. Williamson A, Banerjee S, Zhu X, Philipp I, Iavarone A, Rape M. Regulation of ubiquitin chain initiation to control the timing of substrate degradation. Mol Cell. 2011;42:744-57 pubmed publisher
    ..Based on our results, we propose that initiation motifs and their cognate E2s allow E3 enzymes to exert precise temporal control over substrate degradation. ..
  17. Yuan D, Zhu K, Dang C, Zheng Y, Yan R, Shi L, et al. NS5ATP9 mRNA levels in peripheral blood mononuclear cells predict prognosis in patients with gastric cancer. Med Oncol. 2014;31:106 pubmed publisher
    ..b>NS5ATP9 is significantly overexpressed in gastric cancer tissues, and altered NS5ATP9 expression in human gastric cancer ..
  18. Karg E, Smets M, Ryan J, Forne I, Qin W, Mulholland C, et al. Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells. J Mol Biol. 2017;: pubmed publisher
    ..Most prominently, we identified PCNA-associated factor 15 (PAF15; also known as Pclaf, Ns5atp9, KIAA0101 and OEATC-1) as a specific ubiquitination target of UHRF1...
  19. Samantarrai D, Mallick B. miR-429 inhibits metastasis by targeting KIAA0101 in Soft Tissue Sarcoma. Exp Cell Res. 2017;357:33-39 pubmed publisher
    ..expression profiles of high-grade STS samples with miRNA target predictions and identified miR-429 targeting KIAA0101 as a novel pair, which remain unexplored in STS metastasis...
  20. McPhee F, Suzuki Y, Toyota J, Karino Y, Chayama K, Kawakami Y, et al. High Sustained Virologic Response to Daclatasvir Plus Asunaprevir in Elderly and Cirrhotic Patients with Hepatitis C Virus Genotype 1b Without Baseline NS5A Polymorphisms. Adv Ther. 2015;32:637-49 pubmed publisher
    ..Bristol-Myers Squibb. ..
  21. De Biasio A, de Opakua A, Mortuza G, Molina R, Cordeiro T, Castillo F, et al. Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair. Nat Commun. 2015;6:6439 pubmed publisher
    The intrinsically disordered protein p15(PAF) regulates DNA replication and repair by binding to the proliferating cell nuclear antigen (PCNA) sliding clamp. We present the structure of the human p15(PAF)-PCNA complex...
  22. Abdelgawad I, Radwan N, Hassanein H. KIAA0101 mRNA expression in the peripheral blood of hepatocellular carcinoma patients: Association with some clinicopathological features. Clin Biochem. 2016;49:787-91 pubmed publisher
    ..Recent studies have revealed the involvement of KIAA0101 in HCC development and progression...
  23. Quan M, Liu S, Wang Q, Li G, Zhang Y, Feng S, et al. NS5ATP9 Promotes Beclin 1-Dependent Starvation-Induced Autophagy of Hepatoblastoma Cells. J Cell Biochem. 2015;116:1574-82 pubmed publisher
    b>NS5ATP9, a gene up-regulated by NS5A, plays a crucial oncogenic role in several types of human tumours. However, the underlying mechanisms remain unclear...
  24. Su X, Zhang T, Cheng P, Zhu Y, Li H, Li D, et al. KIAA0101 mRNA overexpression in peripheral blood mononuclear cells acts as predictive marker for hepatic cancer. Tumour Biol. 2014;35:2681-6 pubmed publisher
    b>KIAA0101 always overexpresses in tumor tissues, which is also a marker of tumor recurrence...
  25. Cheng Y, Li K, Diao D, Zhu K, Shi L, Zhang H, et al. Expression of KIAA0101 protein is associated with poor survival of esophageal cancer patients and resistance to cisplatin treatment in vitro. Lab Invest. 2013;93:1276-87 pubmed publisher
    The KIAA0101 protein is overexpressed in various human cancers, including esophageal cancer (EC)...
  26. Zhang C, Xia Y, Zheng Q, Li Z, Guo X, Zhou H, et al. [Effects of KIAA0101 expression on proliferation and invasion of gastric carcinoma MKN-45 cells]. Zhonghua Bing Li Xue Za Zhi. 2012;41:553-7 pubmed publisher
    To investigate the expression of KIAA0101 protein in gastric carcinoma cells, and to explore the effects of its down-regulation on the cell proliferation, cell cycle and invasion...
  27. Wang X, Jung Y, Jun S, Lee S, Wang W, Schneider A, et al. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nat Commun. 2016;7:10633 pubmed publisher
    ..Here we identify PCNA-associated factor (PAF) as a key molecule that controls cancer cell stemness...
  28. Albert B, Léger Silvestre I, Normand C, Ostermaier M, Pérez Fernández J, Panov K, et al. RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle. J Cell Biol. 2011;192:277-93 pubmed publisher
    ..Together our data suggest that localized rRNA production results in spatially constrained rRNA production, which is instrumental for nucleolar assembly. ..
  29. Li H, Ma W, Zuo C, Liang S, Ye Y, Zheng W. [Functional prediction of KIAA0101 gene in human non-small cell lung cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:157-9 pubmed
    To predict the function of KIAA0101 gene over-expressed in human non-small cell lung cancer by bioinformatics methods...
  30. Cordeiro T, Chen P, De Biasio A, Sibille N, Blanco F, Hub J, et al. Disentangling polydispersity in the PCNA-p15PAF complex, a disordered, transient and multivalent macromolecular assembly. Nucleic Acids Res. 2017;45:1501-1515 pubmed publisher
    The intrinsically disordered p15PAF regulates DNA replication and repair when interacting with the Proliferating Cell Nuclear Antigen (PCNA) sliding clamp...
  31. Wang Q, Wang Y, Li Y, Gao X, Liu S, Cheng J. NS5ATP9 contributes to inhibition of cell proliferation by hepatitis C virus (HCV) nonstructural protein 5A (NS5A) via MEK/extracellular signal regulated kinase (ERK) pathway. Int J Mol Sci. 2013;14:10539-51 pubmed publisher
    ..However, on the impact of cell growth, there have been different study results. NS5ATP9, also known as KIAA0101, p15PAF, L5, and OEACT-1, was first identified as a proliferating cell nuclear antigen-binding protein...