Gene Symbol: PCBP4
Description: poly(rC) binding protein 4
Alias: CBP, LIP4, MCG10, poly(rC)-binding protein 4, LYST-interacting protein, RNA binding protein MCG10, alpha-CP4
Species: human
Products:     PCBP4

Top Publications

  1. Pio R, Zudaire I, Pino I, Castaño Z, Zabalegui N, Vicent S, et al. Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer. Cancer Res. 2004;64:4171-9 pubmed
    alpha CP-4 is an RNA-binding protein coded by PCBP4, a gene mapped to 3p21, a common deleted region in lung cancer...
  2. Makeyev A, Liebhaber S. Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. Genomics. 2000;67:301-16 pubmed
    ..These data establish a new subfamily of genes predicted to encode closely related KH-containing RNA-binding proteins with potential functions in posttranscriptional controls. ..
  3. Makeyev A, Liebhaber S. The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA. 2002;8:265-78 pubmed
    ..Clearly the identification of additional binding targets and delineation of corresponding control mechanisms and effector pathways will establish highly informative models for further exploration. ..
  4. Zhu J, Chen X. MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M. Mol Cell Biol. 2000;20:5602-18 pubmed
    ..b>MCG10, a novel cellular p53 target gene, was identified in a cDNA subtraction assay with mRNA isolated from a p53-..
  5. Castaño Z, Vergara Irigaray N, Pajares M, Montuenga L, Pio R. Expression of alpha CP-4 inhibits cell cycle progression and suppresses tumorigenicity of lung cancer cells. Int J Cancer. 2008;122:1512-20 pubmed
    ..In conclusion, expression of alpha CP-4 can inhibit proliferation and tumorigenesis of lung cancer cells, both in vivo and in vitro, by delaying the progression of the cell cycle. ..
  6. Coatti G, Marcarini J, Sartori D, Fidelis Q, Ferreira D, Mantovani M. Cytotoxicity, genotoxicity and mechanism of action (via gene expression analysis) of the indole alkaloid aspidospermine (antiparasitic) extracted from Aspidosperma polyneuron in HepG2 cells. Cytotechnology. 2016;68:1161-70 pubmed publisher
    ..and TRAF2 (endoplasmic reticulum stress); CASP8, CASP9, CASP3, CASP7, BCL-2, BCL-XL BAX and BAX (apoptosis); and PCBP4, ERCC4, OGG1, RAD21 and MLH1 (DNA repair)...
  7. Muñoz P, Correa Llantén D, Blamey J. Production, purification and partial characterization of four lipases from a thermophile isolated from Deception Island. Lipids. 2013;48:527-33 pubmed publisher
    ..Lip1 and Lip2 showed higher activity using p-nitrophenol decanoate as substrate, whereas Lip3 and Lip4 prefer p-nitrophenol laurate...
  8. Yanatori I, Richardson D, Toyokuni S, Kishi F. The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer. J Biol Chem. 2017;292:13205-13229 pubmed publisher
    ..Herein, we demonstrate that HO1 binds to PCBP2, but not to other PCBP family members, namely PCBP1, PCBP3, or PCBP4. Interestingly, HO1 formed a complex with either CPR or PCBP2, and it was demonstrated that PCBP2 competes with ..
  9. Yanatori I, Richardson D, Imada K, Kishi F. Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2. J Biol Chem. 2016;291:17303-18 pubmed publisher
    ..for the first time, we demonstrated using both yeast and mammalian cells that PCBP2, but not PCBP1, PCBP3, or PCBP4, binds with FPN1. Importantly, iron-loaded, but not iron-depleted, PCBP2 interacts with FPN1...

More Information


  1. Yan W, Scoumanne A, Jung Y, Xu E, Zhang J, Zhang Y, et al. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Genes Dev. 2016;30:522-34 pubmed publisher
    Poly(C)-binding protein 4 (PCBP4), also called MCG10 and a target of p53, plays a role in the cell cycle and is implicated in lung tumor suppression...
  2. Ito Y, Narita N, Nomi N, Sugimoto C, Takabayashi T, Yamada T, et al. Suppression of Poly(rC)-Binding Protein 4 (PCBP4) reduced cisplatin resistance in human maxillary cancer cells. Sci Rep. 2015;5:12360 pubmed publisher
    ..In the present study, we specifically examined Poly(rC)-Binding Protein 4 (PCBP4), which reportedly induces G2/M arrest...
  3. Scoumanne A, Cho S, Zhang J, Chen X. The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability. Nucleic Acids Res. 2011;39:213-24 pubmed publisher
    ..b>PCBP4, also called MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor...
  4. Steffens A, Jakoby M, Hulskamp M. Physical, Functional and Genetic Interactions between the BEACH Domain Protein SPIRRIG and LIP5 and SKD1 and Its Role in Endosomal Trafficking to the Vacuole in Arabidopsis. Front Plant Sci. 2017;8:1969 pubmed publisher
    ..associated ATPase Suppressor of K+-transport growth defect1 (SKD1) and its positive regulator, LYST Interacting Protein 5 (LIP5) and report genetic interactions between SPI and SKD1 and LIP5...
  5. Chkheidze A, Liebhaber S. A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins. Mol Cell Biol. 2003;23:8405-15 pubmed
    ..This complexity of alphaCP distribution is likely to contribute to the diverse functions mediated by this group of abundant RNA-binding proteins. ..
  6. Ntostis P, Carter D, Iles D, Huntriss J, Tzetis M, Miller D. Potential sperm contributions to the murine zygote predicted by in silico analysis. Reproduction. 2017;154:777-788 pubmed publisher
    ..At least five sperm RNAs (Hdac11, Fbxo2, Map1lc3a, Pcbp4 and Zfp821) met these requirements for a paternal contribution, which with complementary maternal co-..
  7. Leidgens S, Bullough K, Shi H, Li F, Shakoury Elizeh M, Yabe T, et al. Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin. J Biol Chem. 2013;288:17791-802 pubmed publisher
    ..and ferritin in an iron-sensitive, ccc1 yeast strain intensified the toxic effects of iron, whereas expression of PCBP4 protected the cells from iron toxicity...
  8. Taylor W, Stark G. Regulation of the G2/M transition by p53. Oncogene. 2001;20:1803-15 pubmed
    ..p53 induces transcription of the reprimo, B99, and mcg10 genes, all of which contribute to the arrest of cells in G2, but the mechanisms of cell cycle arrest by these ..