PCAF

Summary

Gene Symbol: PCAF
Description: lysine acetyltransferase 2B
Alias: CAF, P/CAF, PCAF, histone acetyltransferase KAT2B, CREBBP-associated factor, K(lysine) acetyltransferase 2B, histone acetylase PCAF, histone acetyltransferase PCAF, p300/CBP-associated factor
Species: human
Products:     PCAF

Top Publications

  1. Puri P, Sartorelli V, Yang X, Hamamori Y, Ogryzko V, Howard B, et al. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol Cell. 1997;1:35-45 pubmed
    b>PCAF is a histone acetyltransferase that associates with p300/CBP and competes with E1A for access to them...
  2. Kahata K, Hayashi M, Asaka M, Hellman U, Kitagawa H, Yanagisawa J, et al. Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5. Genes Cells. 2004;9:143-51 pubmed
    ..GCN5 is structurally similar to PCAF, which was previously identified as a coactivator for receptor-regulated Smads (R-Smads) for TGF-beta signalling ..
  3. Wang Y, Faiola F, Xu M, Pan S, Martinez E. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem. 2008;283:33808-15 pubmed publisher
    ..In contrast, vertebrate organisms, express two paralogous GCN5-like acetyltransferases (GCN5 and PCAF), which have been found so far only in SAGA-type complexes referred to hereafter as the STAGA (SPT3-TAF9-GCN5/PCAF ..
  4. Zheng X, Gai X, Ding F, Lu Z, Tu K, Yao Y, et al. Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling. Mol Cancer. 2013;12:96 pubmed publisher
    b>PCAF is an important intrinsic histone acetyltransferases. This study tried to establish the effect of PCAF on HCC cell apoptosis...
  5. Xenaki G, Ontikatze T, Rajendran R, Stratford I, Dive C, Krstic Demonacos M, et al. PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene. 2008;27:5785-96 pubmed publisher
    ..conditions p53 acetylation is reduced to a greater extent at K320 site targeted by P300/CBP-associated factor (PCAF) than at K382 site targeted by p300/CBP...
  6. Schiltz R, Mizzen C, Vassilev A, Cook R, Allis C, Nakatani Y. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. J Biol Chem. 1999;274:1189-92 pubmed
    ..We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes...
  7. Pavan Kumar P, Purbey P, Sinha C, Notani D, Limaye A, Jayani R, et al. Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. Mol Cell. 2006;22:231-43 pubmed
    ..We show here that phosphorylation by PKC acts as a switch to determine whether SATB1 interacts with HDAC1 or PCAF. Phosphorylation and dephosphorylation of SATB1 exerted opposing effects on MAR-linked reporter activity in vivo...
  8. Fu M, Wang C, Reutens A, Wang J, Angeletti R, Siconolfi Baez L, et al. p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. J Biol Chem. 2000;275:20853-60 pubmed
    ..The identification of the AR as a direct target of histone acetyltransferase co-activators has important implications for targeting inhibitors of AR function. ..
  9. Cotter M, Robertson E. Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha. Mol Cell Biol. 2000;20:5722-35 pubmed

More Information

Publications81

  1. Itoh S, Ericsson J, Nishikawa J, Heldin C, ten Dijke P. The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling. Nucleic Acids Res. 2000;28:4291-8 pubmed
    ..Here we investigated the possible co-activator function of P/CAF in TGF-beta/Smad signaling. P/CAF was found to interact directly with Smad3 in vitro...
  2. Blanco García N, Asensio Juan E, de la Cruz X, Martínez Balbás M. Autoacetylation regulates P/CAF nuclear localization. J Biol Chem. 2009;284:1343-52 pubmed publisher
    ..The acetyltransferase P/CAF is autoacetylated and acetylated by p300 in vivo...
  3. Korzus E, Torchia J, Rose D, Xu L, Kurokawa R, McInerney E, et al. Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science. 1998;279:703-7 pubmed
    ..including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or assembly properties...
  4. Ianari A, Gallo R, Palma M, Alesse E, Gulino A. Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage. J Biol Chem. 2004;279:30830-5 pubmed
    ..Finally, we report that the formation of E2F1-p300/CREB-binding protein-associated factor (P/CAF) complexes is preferentially induced in doxorubicin-treated cells, and that P/CAF acetyltransferase (HAT), but not ..
  5. Mateo F, Vidal Laliena M, Canela N, Zecchin A, Martínez Balbás M, Agell N, et al. The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res. 2009;37:7072-84 pubmed publisher
    ..We report here that the transcriptional co-activator PCAF directly interacts with cdk2. This interaction is mainly produced during S and G(2)/M phases of the cell cycle...
  6. Muth V, Nadaud S, Grummt I, Voit R. Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J. 2001;20:1353-62 pubmed
    ..of the promoter-proximal terminator, we found that TTF-I associates with the p300/CBP-associated factor PCAF, suggesting that TTF-I may target histone acetyltransferase to the rDNA promoter...
  7. Sartorelli V, Puri P, Hamamori Y, Ogryzko V, Chung G, Nakatani Y, et al. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol Cell. 1999;4:725-34 pubmed
    p300/CBP and PCAF coactivators have acetyltransferase activities and regulate transcription, cell cycle progression, and differentiation. They are both required for MyoD activity and muscle differentiation...
  8. Santos Rosa H, Valls E, Kouzarides T, Martínez Balbás M. Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res. 2003;31:4285-92 pubmed
    P/CAF is a histone acetyltransferase enzyme which was originally identified as a CBP/p300-binding protein. In this manuscript we report that human P/CAF is acetylated in vivo...
  9. Liu L, Scolnick D, Trievel R, Zhang H, Marmorstein R, Halazonetis T, et al. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol. 1999;19:1202-9 pubmed
    ..suggest that full transcriptional activity of p53 requires the coactivators CREB binding protein (CBP)/p300 and PCAF. These coactivators interact with each other, and both possess intrinsic histone acetyltransferase activity...
  10. Ogryzko V, Kotani T, Zhang X, Schiltz R, Howard T, Yang X, et al. Histone-like TAFs within the PCAF histone acetylase complex. Cell. 1998;94:35-44 pubmed
    b>PCAF histone acetylase plays a role in regulation of transcription, cell cycle progression, and differentiation. Here, we show that PCAF is found in a complex consisting of more than 20 distinct polypeptides...
  11. Pediconi N, Guerrieri F, Vossio S, Bruno T, Belloni L, Schinzari V, et al. hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage. Mol Cell Biol. 2009;29:1989-98 pubmed publisher
    ..Here we show that the hSirT1/PCAF interaction controls the E2F1/p73 apoptotic pathway...
  12. Perez R, Knights C, Sahu G, Catania J, Kolukula V, Stoler D, et al. Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway. J Cell Physiol. 2010;225:394-405 pubmed publisher
    ..Here, we show that the PCAF acetyl-transferase is down-regulated in tumors harboring p53 mutants, where its re-expression leads to p53 ..
  13. Jin Y, Zeng S, Lee H, Lu H. MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation. J Biol Chem. 2004;279:20035-43 pubmed
    ..a negative feedback regulator of the tumor suppressor p53, inhibits p300/CREB-binding protein-associated factor (PCAF)-mediated p53 acetylation. Our further study showed that MDM2 also regulates the stability of PCAF...
  14. Poux A, Marmorstein R. Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates. Biochemistry. 2003;42:14366-74 pubmed publisher
    ..protein (tGcn5) bound to its preferred histone H3 substrate, revealing the mode of substrate binding by the Gcn5/PCAF family of HAT proteins...
  15. Mateo F, Vidal Laliena M, Canela N, Busino L, Martinez Balbas M, Pagano M, et al. Degradation of cyclin A is regulated by acetylation. Oncogene. 2009;28:2654-66 pubmed publisher
    ..Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54, 68, 95 and 112...
  16. Song C, Keller K, Murata K, Asano H, Stamatoyannopoulos G. Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. J Biol Chem. 2002;277:7029-36 pubmed
    ..Our results show that both CBP/p300 and p300/CBP-associated factor (PCAF) enhance FKLF2 transcriptional activity...
  17. Chen H, Lin R, Schiltz R, Chakravarti D, Nash A, Nagy L, et al. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell. 1997;90:569-80 pubmed
    ..ACTR also recruits two other nuclear factors, CBP and P/CAF, and thus plays a central role in creating a multisubunit coactivator complex...
  18. Jin Y, Zeng S, Dai M, Yang X, Lu H. MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. J Biol Chem. 2002;277:30838-43 pubmed
    ..Because PCAF (p300/CREB-binding protein-associated factor) also acetylates and activates p53 after DNA damage, in this study we ..
  19. Mujtaba S, He Y, Zeng L, Farooq A, Carlson J, Ott M, et al. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell. 2002;9:575-86 pubmed
    ..association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF)...
  20. Sakaguchi K, Herrera J, Saito S, Miki T, Bustin M, Vassilev A, et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 1998;12:2831-41 pubmed
    ..acetylated in vitro at separate sites by two different histone acetyltransferases (HATs), the coactivators p300 and PCAF. p300 acetylates Lys-382 in the carboxy-terminal region of p53, whereas PCAF acetylates Lys-320 in the nuclear ..
  21. Linares L, Kiernan R, Triboulet R, Chable Bessia C, Latreille D, Cuvier O, et al. Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2. Nat Cell Biol. 2007;9:331-8 pubmed
    The p300-CBP-associated factor (PCAF) is a histone acetyltransferase (HAT) involved in the reversible acetylation of various transcriptional regulators, including the tumour suppressor p53...
  22. Tuo H, Zheng X, Tu K, Zhou Z, Yao Y, Liu Q. [Expression of PCAF in hepatocellular carcinoma and its clinical significance]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:297-300 pubmed
    To investigate the expression of P300/CBP-associated factor (PCAF) in hepatocellular carcinoma (HCC) and its clinical significance...
  23. Huang W, Zhao S, Ammanamanchi S, Brattain M, Venkatasubbarao K, Freeman J. Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. J Biol Chem. 2005;280:10047-54 pubmed
    ..of cells with TSA activates the TbetaRII promoter in a time-dependent manner through the recruitment of p300 and PCAF into a Sp1.NF-Y.HDAC complex that binds this DNA element...
  24. Sabò A, Lusic M, Cereseto A, Giacca M. Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription. Mol Cell Biol. 2008;28:2201-12 pubmed publisher
    ..Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by ..
  25. Cereseto A, Manganaro L, Gutierrez M, Terreni M, Fittipaldi A, Lusic M, et al. Acetylation of HIV-1 integrase by p300 regulates viral integration. EMBO J. 2005;24:3070-81 pubmed
    ..This is the first demonstration that HIV-1 IN activity is specifically regulated by post-translational modification. ..
  26. Fulco M, Schiltz R, Iezzi S, King M, Zhao P, Kashiwaya Y, et al. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell. 2003;12:51-62 pubmed
    ..Sir2 forms a complex with the acetyltransferase PCAF and MyoD and, when overexpressed, retards muscle differentiation...
  27. Ogryzko V, Schiltz R, Russanova V, Howard B, Nakatani Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell. 1996;87:953-9 pubmed
    ..One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic histone acetyltransferase activity...
  28. Yang X, Ogryzko V, Nishikawa J, Howard B, Nakatani Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 1996;382:319-24 pubmed
    ..A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A...
  29. Obrdlik A, Kukalev A, Louvet E, Farrants A, Caputo L, Percipalle P. The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription. Mol Cell Biol. 2008;28:6342-57 pubmed publisher
    ..interaction assays, and biochemical fractionation of nuclear extracts that the histone acetyltransferase (HAT) PCAF associates with actin and hnRNP U...
  30. Pons D, Trompet S, de Craen A, Thijssen P, Quax P, De Vries M, et al. Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies. Heart. 2011;97:143-50 pubmed publisher
    ..counterbalancing influence of genetic variation in the promoter of the gene encoding P300/CBP associated factor (PCAF), a lysine acetyltransferase (KAT), on coronary heart disease (CHD) and mortality...
  31. Love I, Sekaric P, Shi D, Grossman S, Androphy E. The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3. Cell Cycle. 2012;11:2458-66 pubmed publisher
    ..Several histone acetyl transferases (HATs), including p300, CBP, PCAF and GCN5 have been implicated in the activation of p53-dependent transcription of the cyclin-dependent kinase (cdk) ..
  32. Patel J, Du Y, Ard P, Phillips C, Carella B, Chen C, et al. The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol. 2004;24:10826-34 pubmed
    ..in part on the recruitment of cofactor complexes containing the histone acetyltransferases mammalian GCN5 (mGCN5)/PCAF and TIP60...
  33. Kiernan R, Vanhulle C, Schiltz L, Adam E, Xiao H, Maudoux F, et al. HIV-1 tat transcriptional activity is regulated by acetylation. EMBO J. 1999;18:6106-18 pubmed
    ..trans-activator protein (Tat)-associated histone acetyltransferases (TAHs), p300 and p300/CBP-associating factor (PCAF), assist functionally in the activation of chromosomally integrated HIV-1 LTR...
  34. Rhee H, Kim H, Choi J, Woo H, Yoo J, Nahm J, et al. Keratin 19 Expression in Hepatocellular Carcinoma Is Regulated by Fibroblast-Derived HGF via a MET-ERK1/2-AP1 and SP1 Axis. Cancer Res. 2018;78:1619-1631 pubmed publisher
    ..of fibrous tumor stroma in KRT19-positive HCC, suggesting that cross-talk between cancer-associated fibroblasts (CAF) and tumor epithelial cells could regulate KRT19 expression...
  35. Kong L, Qiao Z, Xie G, Qin Z, Zhao B, Yu H, et al. Spectroscopic characteristics, continuous-wave and mode-locking laser performances of Tm,Y:CaF2 disordered crystal. Opt Express. 2017;25:21267-21274 pubmed publisher
    The spectroscopic characteristics, continuous-wave (CW) and mode-locking laser performances of Tm,Y:CaF2 disordered crystal were studied. A maximum CW output power of 586 mW was obtained with a slope efficiency of 26%...
  36. Shimoda M, Principe S, Jackson H, Luga V, Fang H, Molyneux S, et al. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nat Cell Biol. 2014;16:889-901 pubmed publisher
    ..the tumour-stromal compartment and show that complete Timp loss is sufficient for the acquisition of hallmark CAF functions. Exosomes produced by TIMPless fibroblasts induce cancer cell motility and cancer stem cell markers...
  37. Bazzano M, Paz D, Elia E. Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats. J Nutr Biochem. 2017;42:194-202 pubmed publisher
    ..The mechanisms linking obesity to these pathologies are not fully understood. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects western diet habits...
  38. Carrer A, Parris J, Trefely S, Henry R, Montgomery D, Torres A, et al. Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels. J Biol Chem. 2017;292:3312-3322 pubmed publisher
    ..Butyryl-CoA and isobutyryl-CoA interacted with the acetyltransferase P300/CBP-associated factor (PCAF) in liver lysates and inhibited its activity in vitro This study thus provides evidence that diet can impact ..
  39. Tsai W, Huang C, Jiang S. QA measurement of gamma-ray dose and neutron activation using TLD-400 for BNCT beam. Appl Radiat Isot. 2018;137:73-79 pubmed publisher
    TLD-400 (CaF2:Mn) chips were applied for the gamma-ray dose measurement in a PMMA phantom exposed to a BNCT beam because of their very low neutron sensitivity...
  40. Xie A, Bermudez V, Folk W. Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: acetylation of large T antigen. Mol Cell Biol. 2002;22:7907-18 pubmed
    The PCAF and GCN5 acetyltransferases, but not p300 or CBP, stimulate DNA replication when tethered near the polyomavirus origin...
  41. Takeshita A, Cardona G, Koibuchi N, Suen C, Chin W. TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem. 1997;272:27629-34 pubmed
    ..These results suggest that TRAM-1 is a coactivator that may exhibit its activity by interacting with subdomains of NRs other than the AF-2 region, in contrast to SRC-1/TIF2. ..
  42. Men W, Zheng J, Wang H, Ni Y, Aono T, Maxwell S, et al. Establishing rapid analysis of Pu isotopes in seawater to study the impact of Fukushima nuclear accident in the Northwest Pacific. Sci Rep. 2018;8:1892 pubmed publisher
    ..to rapidly determine Pu isotopes in seawater by SF-ICP-MS including Fe(OH)2 primary co-precipitation, CaF2/LaF3 secondary co-precipitation and TEVA+UTEVA+DGA extraction chromatographic separation was ..
  43. Shin S, Janknecht R. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. J Cell Biochem. 2007;101:1252-65 pubmed
    ..In addition, we show that the p300/CBP-associated protein (P/CAF) also interacts with p72 RNA helicase, and both this interaction and the binding to p300/CBP are mediated by the N-..
  44. Liu C, Zhang Y, Lim S, Hosaka K, Yang Y, Pavlova T, et al. A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis. Clin Cancer Res. 2017;23:4769-4779 pubmed publisher
    ..In particular, the interaction of malignant cells with other cell types including cancer-associated fibroblasts (CAF) in promoting metastasis at the early stage of tumor development remains largely unknown...
  45. Gibellini D, Vitone F, Schiavone P, Re M. HIV-1 tat protein and cell proliferation and survival: a brief review. New Microbiol. 2005;28:95-109 pubmed
    ..This review focuses on some aspects of Tat biological activity with particular regard to effects of Tat on cell proliferation and survival regulation. ..
  46. Li H, Hao S, Yang C, Chen G. Synthesis of Multicolor Core/Shell NaLuF?:Yb3+/Ln3+@CaF? Upconversion Nanocrystals. Nanomaterials (Basel). 2017;7: pubmed publisher
    ..Here, we describe a strategy to fabricate multicolor core @ shell ?-NaLuF?:Yb3+/Ln3+@CaF? (Ln = Er, Ho, Tm) upconversion nanocrystals (UCNCs) based on the newly established host lattice of sodium lutetium ..
  47. Zhou W, Xu G, Wang Y, Xu Z, Liu X, Xu X, et al. Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells. Cell Cycle. 2017;16:73-81 pubmed publisher
    ..Previous studies have shown that cancer associated fibroblast (CAF) in TME is an important promoter of tumor initiation and progression...
  48. Sugiyama H, Ishii T, Nakanishi T, Park I. Dual origin multiple plexus-like coronary to pulmonary artery fistulas - Consideration of their etiology and therapeutic strategy. J Cardiol. 2017;69:747-751 pubmed publisher
    ..pulmonary fistulas (CAPFs) originating from bilateral coronary arteries are a rare type of coronary artery fistula (CAF). Their etiology and therapeutic strategy are discussed...
  49. Mazza D, Infante P, Colicchia V, Greco A, Alfonsi R, Siler M, et al. PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress. Cell Death Differ. 2013;20:1688-97 pubmed publisher
    ..This inhibition is dependent on the p53-mediated elevation of the acetyltransferase p300/CBP-associated factor (PCAF). Notably, we identify PCAF as a novel E3 ubiquitin ligase of Gli1...
  50. Eren G, Tervahartiala T, Sorsa T, Atilla G. Cytokine (interleukin-1beta) and MMP levels in gingival crevicular fluid after use of platelet-rich fibrin or connective tissue graft in the treatment of localized gingival recessions. J Periodontal Res. 2016;51:481-8 pubmed publisher
    ..in gingival crevicular fluid during the early and late stages of healing in gingival recession sites treated with coronally advanced flap plus platelet-rich fibrin (CAF+PRF) compared with CAF plus connective tissue graft (CAF+CTG).
  51. Beharry A, Judge A. Differential expression of HDAC and HAT genes in atrophying skeletal muscle. Muscle Nerve. 2015;52:1098-101 pubmed publisher
    ..The mRNA levels of Hdac2, Hdac4, Hdac6, Sirt1, p300, Cbp, and Pcaf increased, and Hdac7 decreased in skeletal muscle in each experimental model of muscle atrophy...
  52. Guo Y, Shen T, Wang C, Sun J, Wang X. Rapid removal of caffeine in aqueous solutions by peroxymonosulfate oxidant activated with cobalt ion. Water Sci Technol. 2015;72:478-83 pubmed publisher
    The removal of caffeine (CAF) in aqueous solution by peroxymonosulfate oxidant activated with cobalt ion was investigated under a variety of operating conditions...
  53. Piekna Przybylska D, Bambara R, Balakrishnan L. Acetylation regulates DNA repair mechanisms in human cells. Cell Cycle. 2016;15:1506-17 pubmed publisher
    ..Hypoacetylation of the cells in the presence of acetyltransferase inhibitor, garcinol generally reduced efficiency of BER of 8-oxoG damage, indicating that some steps in the pathway are stimulated by acetylation. ..
  54. Tini M, Benecke A, Um S, Torchia J, Evans R, Chambon P. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell. 2002;9:265-77 pubmed
    ..These observations reveal a potential regulatory role for protein acetylation in base mismatch repair and a role for CBP/p300 in maintaining genomic stability. ..
  55. Wardell S, Boonyaratanakornkit V, Adelman J, Aronheim A, Edwards D. Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator. Mol Cell Biol. 2002;22:5451-66 pubmed
    ..domain and makes direct protein interactions with other coactivators, including CBP and p300 CBP-associated factor (pCAF), but not with SRCs...
  56. Franco Barraza J, Francescone R, Luong T, Shah N, Madhani R, Cukierman G, et al. Matrix-regulated integrin ?v?5 maintains ?5?1-dependent desmoplastic traits prognostic of neoplastic recurrence. elife. 2017;6: pubmed publisher
    ..identified tumor-restricting and tumor-promoting roles of PDAC-associated desmoplasia, suggesting that individual CAF/D-ECM protein constituents have distinguishable tumorigenic and tumor-repressive functions...
  57. Rice A. The HIV-1 Tat team gets bigger. Cell Host Microbe. 2010;7:179-81 pubmed publisher
    ..Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function. ..
  58. Shimahara A, Yamakawa N, Nishikata I, Morishita K. Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. J Biol Chem. 2010;285:16967-77 pubmed publisher
    ..EVI1 was acetylated by the histone acetyltransferase p300/CBP association factor (P/CAF) in myeloid leukemia cells and hematopoietic progenitor cells...
  59. Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G. Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles. J Biol Chem. 2001;276:44936-43 pubmed
    ..two co-activators cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF), both of which have histone acetyltransferase (HAT) activity...
  60. Wang Y, Ding Y, Li L, Hu P. Nitrogen-doped carbon nanotubes decorated poly (L-Cysteine) as a novel, ultrasensitive electrochemical sensor for simultaneous determination of theophylline and caffeine. Talanta. 2018;178:449-457 pubmed publisher
    ..were fabricated and applied for the simultaneous voltammetric determination of theophylline (THEO) and caffeine (CAF)...
  61. Gong A, Eischeid A, Xiao J, Zhao J, Chen D, Wang Z, et al. miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells. BMC Cancer. 2012;12:492 pubmed publisher
    ..activity of AR involves chromatin recruitment of co-activators, including the p300/CBP-associated factor (PCAF)...
  62. Shen M, Zhou T, Xie W, Ling T, Zhu Q, Zong L, et al. The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation. PLoS ONE. 2013;8:e62668 pubmed publisher
    ..Here we show that a complex consisting of CSB, RNA polymerase I and histone acetyltransferase PCAF is present at the rDNA promoters in active state...
  63. Boulos D, Zamorski M. Contribution of the Mission in Afghanistan to the Burden of Past-Year Mental Disorders in Canadian Armed Forces Personnel, 2013. Can J Psychiatry. 2016;61:64S-76S pubmed publisher
    ..contribution of the mission in Afghanistan to the burden of mental health problems in the Canadian Armed Forces (CAF)...
  64. Pan C, Mezei M, Mujtaba S, Muller M, Zeng L, Li J, et al. Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor. J Med Chem. 2007;50:2285-8 pubmed
    Human immunodeficiency virus 1 (HIV-1) trans-activator Tat recruits the human transcriptional coactivator PCAF (p300/CREB binding protein-associated factor) to facilitate transcription of the integrated HIV-1 provirus...
  65. Zhu L, Sun L, Hu Y, Jiang Y, Liu H, Shen X, et al. PCAF impairs endometrial receptivity and embryo implantation by down-regulating ?3-integrin expression via HOXA10 acetylation. J Clin Endocrinol Metab. 2013;98:4417-28 pubmed publisher
    ..aim of this study was to assess the effect of HOXA10 acetylation by p300/CREB-binding protein-associated factor (PCAF) in the embryo implantation process...
  66. Goel A, Janknecht R. Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Mol Cell Biol. 2003;23:6243-54 pubmed
    ..that ER81 is acetylated by two coactivators/acetyltransferases, p300 and p300- and CBP-associated factor (P/CAF) in vitro and in vivo...
  67. Liou L, Herrmann C, Rice A. HIV-1 infection and regulation of Tat function in macrophages. Int J Biochem Cell Biol. 2004;36:1767-75 pubmed
    ..Future studies of cyclin T1 regulation in macrophages may suggest means of manipulating expression of this crucial cellular co-factor for therapeutic benefit in HIV-1 infected individuals. ..
  68. Vienonen A, Miettinen S, Bläuer M, Martikainen P, Tomas E, Heinonen P, et al. Expression of nuclear receptors and cofactors in human endometrium and myometrium. J Soc Gynecol Investig. 2004;11:104-12 pubmed
    ..AIB1 (amplified in breast cancer-1), CBP (cyclic adenosine monophosphate response element binding protein), pCAF (p300/CBP-associated factor), TIF2 (transcription intermediary factor-2), N-CoR (nuclear receptor corepressor), and ..
  69. Zhang P, Liu Y, Jin C, Zhang M, Lv L, Zhang X, et al. Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis. Stem Cells. 2016;34:2332-41 pubmed publisher
    ..However, the molecular mechanisms are poorly understood. Here, we show that histone H3K9 acetyltransferase PCAF plays a critical role in osteogenic differentiation of MSCs...
  70. Amini S, Mameli G, Del Valle L, Skowronska A, Reiss K, Gelman B, et al. p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28. Mol Cell Biol. 2005;25:8126-38 pubmed
    ..Association of p73 with Tat prevented the acetylation of Tat on lysine 28 by PCAF. Functional studies including RNA interference showed that p73 inhibited Tat stimulation of the HIV-1 promoter...
  71. Zhang D, Ding L, Li Y, Ren J, Shi G, Wang Y, et al. Midkine derived from cancer-associated fibroblasts promotes cisplatin-resistance via up-regulation of the expression of lncRNA ANRIL in tumour cells. Sci Rep. 2017;7:16231 pubmed publisher
    ..In conclusion, we firstly describe that CAFs in the TME contribute to the high level of MK in tumours and that CAF-derived MK can promote cisplatin resistance via the elevated expression of lncRNA ANRIL.
  72. Zhang S, Sun G, Wang Z, Wan Y, Guo J, Shi L. PCAF-mediated Akt1 acetylation enhances the proliferation of human glioblastoma cells. Tumour Biol. 2015;36:1455-62 pubmed publisher
    ..Mechanistically, PCAF-mediated Akt1 acetylation enhanced Akt1 phosphorylation at both sites of Thr(308) and Ser(473) and further promoted ..