PBX1

Summary

Gene Symbol: PBX1
Description: PBX homeobox 1
Alias: CAKUHED, pre-B-cell leukemia transcription factor 1, homeobox protein PBX1, homeobox protein PRL, pre-B-cell leukemia homeobox 1
Species: human
Products:     PBX1

Top Publications

  1. Smith K, Chanda S, Lingbeek M, Ross D, Botstein D, Van Lohuizen M, et al. Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1. Mol Cell. 2003;12:393-400 pubmed
    ..lymphoid malignancies, but are consistently absent in pre-B cell leukemias induced by the chimeric oncoprotein E2a-Pbx1 created by t(1;19) chromosomal translocations...
  2. Wang H, Chu W, Wang X, Zhang Z, Elbein S. Evaluation of sequence variants in the pre-B cell leukemia transcription factor 1 gene: a positional and functional candidate for type 2 diabetes and impaired insulin secretion. Mol Genet Metab. 2005;86:384-91 pubmed
    Pre-B cell leukemia transcription factor 1 (PBX1) encodes a homeodomain containing protein that is essential for pancreatic development and interacts with insulin promoter factor 1 to regulate insulin secretion...
  3. Hunger S, Galili N, Carroll A, Crist W, Link M, Cleary M. The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood. 1991;77:687-93 pubmed
    ..The t(1;19) juxtaposes the E2A gene from chromosome 19 with the PBX1 gene on chromosome 1, leading to the production of fusion transcripts and resultant chimeric proteins that contain ..
  4. Kikugawa T, Kinugasa Y, Shiraishi K, Nanba D, Nakashiro K, Tanji N, et al. PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation. Prostate. 2006;66:1092-9 pubmed
    ..DNA microarray revealed that Pbx1 is a prominent suppressed gene in PLZF-overexpressing DU145 cells...
  5. Ma J, Qin Y, Liu W, Duan H, Xia M, Chen Z. Analysis of PBX1 mutations in 192 Chinese women with Müllerian duct abnormalities. Fertil Steril. 2011;95:2615-7 pubmed publisher
    We examined the PBX1 gene in 192 Chinese women with Müllerian duct abnormalities and revealed 2 known single nucleotide polymorphisms: c.61 > A in exon 1 and c.998-1330A>G in intron 7...
  6. Delval S, Taminiau A, Lamy J, Lallemand C, Gilles C, Noel A, et al. The Pbx interaction motif of Hoxa1 is essential for its oncogenic activity. PLoS ONE. 2011;6:e25247 pubmed publisher
    ..Therefore, the hexapeptide motif of Hoxa1 is required to confer its oncogenic activity, supporting the view that this activity relies on the ability of Hoxa1 to interact with Pbx. ..
  7. Magnani L, Ballantyne E, Zhang X, Lupien M. PBX1 genomic pioneer function drives ER? signaling underlying progression in breast cancer. PLoS Genet. 2011;7:e1002368 pubmed publisher
    Altered transcriptional programs are a hallmark of diseases, yet how these are established is still ill-defined. PBX1 is a TALE homeodomain protein involved in the development of different types of cancers...
  8. Nourse J, Mellentin J, Galili N, Wilkinson J, Stanbridge E, Smith S, et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell. 1990;60:535-45 pubmed
    ..Identical E2A-prl mRNA junctions were detected by PCR in three t(1;19)-carrying cell lines, indicating that the fusion transcripts and predicted chimeric protein are a consistent feature of this translocation. ..
  9. Kamps M, Murre C, Sun X, Baltimore D. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell. 1990;60:547-55 pubmed
    ..Therefore, the production of a chimeric E2A-Prl protein may contribute to the acute lymphoblastic phenotype by directly altering the expression of genes normally responsive to the Prl homeoprotein...

More Information

Publications109 found, 100 shown here

  1. Chang C, Shen W, Rozenfeld S, Lawrence H, Largman C, Cleary M. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev. 1995;9:663-74 pubmed
    The human proto-oncogene PBX1 codes for a homolog of Drosophila extradenticle, a divergent homeo domain protein that modulates the developmental and DNA-binding specificity of select HOM proteins...
  2. Piper D, Batchelor A, Chang C, Cleary M, Wolberger C. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell. 1999;96:587-97 pubmed
    ..A majority of the vertebrate Hox proteins bind DNA as heterodimers with the Pbx1 homeodomain protein. We report here the 2...
  3. Kim S, Selleri L, Lee J, Zhang A, Gu X, Jacobs Y, et al. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat Genet. 2002;30:430-5 pubmed
    b>Pbx1 is a member of the TALE (three-amino acid loop extension) class of homeodomain transcription factors, which are components of hetero-oligomeric protein complexes thought to regulate developmental gene expression and to maintain ..
  4. LaRonde LeBlanc N, Wolberger C. Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev. 2003;17:2060-72 pubmed
    ..bind DNA cooperatively with members of the PBC family of TALE-type homeodomain proteins, which includes human Pbx1. Cooperative DNA binding between HOX and PBC proteins requires a residue N-terminal to the HOX homeodomain termed ..
  5. Liu D, Gu Z, Cao X, Liu H, Li J. Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas. World J Gastroenterol. 2005;11:1562-6 pubmed
    To evaluate the expression pattern of two novel oncofetal antigens, the HoxD9 and Pbx1 homeoproteins in esophageal squamous cell carcinomas (ESCCs) to determine what role they would play in the carcinogenesis of ESCC...
  6. Charboneau A, East L, Mulholland N, Rohde M, Boudreau N. Pbx1 is required for Hox D3-mediated angiogenesis. Angiogenesis. 2005;8:289-96 pubmed
    ..Since binding of Hox 3 factors to target DNA is enhanced by the co-factor Pbx, we investigated whether Pbx1 is also required for angiogenesis. We observed that EC predominantly express the Pbx1b isoform...
  7. Park J, Shih I, Wang T. Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. Cancer Res. 2008;68:8852-60 pubmed publisher
    ..In this study, we have identified Pbx1, a proto-oncogene in hematopoietic malignancy, as a Notch3 target gene...
  8. Monica K, Galili N, Nourse J, Saltman D, Cleary M. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991;11:6149-57 pubmed
    Two new homeobox genes, PBX2 and PBX3, were isolated on the basis of their extensive homology to PBX1, a novel human homeobox gene involved in t(1;19) translocation in acute pre-B-cell leukemias...
  9. Shen W, Rozenfeld S, Lawrence H, Largman C. The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target. J Biol Chem. 1997;272:8198-206 pubmed
    ..These data suggest that Abd-B-like Hox proteins bind to a novel TTAC site and can be divided by their cooperative binding to DNA with Pbx1a. ..
  10. Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F. The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J. 1998;17:1434-45 pubmed
    ..Indeed, we observe the formation of a ternary Prep1-Pbx1-HOXB1 complex on a HOXB1-responsive target in vitro...
  11. Jacobs Y, Schnabel C, Cleary M. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol. 1999;19:5134-42 pubmed
    ..As a consequence, Hoxb1 employs Pbx and Meis-related proteins, as a pair of essential cofactors in a higher-order molecular complex, to mediate its transcriptional effects on an endogenous Hox response element. ..
  12. McWhirter J, Neuteboom S, Wancewicz E, Monia B, Downing J, Murre C. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1999;96:11464-9 pubmed
    ..factor containing the N-terminal transactivation domain of E2A fused to the C-terminal DNA-binding homeodomain of Pbx1. Here, we show that the E2A-Pbx1 fusion protein activates the expression of a novel WNT gene, WNT-16...
  13. Tovar C, Zerón H, Romero M, Sánchez Y, Romero I. Glycogen Synthase Kinase-3? (GSK-3?) and Nuclear Factor Kappa-B (NFKB) in Childhood Acute Lymphoblastic Leukemia. Adv Clin Exp Med. 2016;25:1139-1147 pubmed publisher
    ..Abnormal genes were found in 7 (23.33%) patients, ETV-RUNX1 in 3, followed by TCF3-PBX1 (two), STL1-TAL1 (one), and BCR-ABL1 (one)...
  14. Akhter A, Mughal M, Elyamany G, Sinclair G, Azma R, Masir N, et al. Multiplexed automated digital quantification of fusion transcripts: comparative study with fluorescent in-situ hybridization (FISH) technique in acute leukemia patients. Diagn Pathol. 2016;11:89 pubmed publisher
    ..A high degree of correlation was noted for MLL/AF4 (85 sensitivity/100 specificity) and TCF3-PBX1 (75 % sensitivity/100 % specificity) probes...
  15. Xu Y, Zhao W, Olson S, Prabhakara K, Zhou X. Alternative splicing links histone modifications to stem cell fate decision. Genome Biol. 2018;19:133 pubmed publisher
    ..datasets from Roadmap/ENCODE projects, we exemplify this mechanism by a cell-cycle-related transcription factor, PBX1, which regulates the pluripotency regulatory network by binding to NANOG...
  16. Haldar R, Shaashua L, Lavon H, Lyons Y, Zmora O, Sharon E, et al. Perioperative inhibition of β-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome. Brain Behav Immun. 2018;73:294-309 pubmed publisher
    ..at T2/T3 in several transcription factors that in primary tumors indicate poor prognosis (CUX1, THRa, EVI1, RORa, PBX1, and T3R), angiogenesis (YY1), EMT (GATA1 and deltaEF1/ZEB1), proliferation (GATA2), and glucocorticoids response (..
  17. Wang B, Zheng Y, Shi H, Du X, Zhang Y, Wei B, et al. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2017;16:296-307 pubmed publisher
    ..In addition, the mRNA levels of Pbx1 (pre-B-cell leukemia homeobox 1, an interacting protein of Zfp462) and Hoxb8 decreased in the brains of Zfp462+..
  18. Mahé E, Madigou T, Sérandour A, Bizot M, Avner S, Chalmel F, et al. Cytosine modifications modulate the chromatin architecture of transcriptional enhancers. Genome Res. 2017;27:947-958 pubmed publisher
    ..and chromatin characteristics of enhancers bound by the pioneer transcription factors FOXA1, MEIS1, and PBX1 were interrogated...
  19. Xu B, Cai L, Butler J, Chen D, Lu X, Allison D, et al. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports. 2018;10:675-683 pubmed publisher
    ..of HSC-specific gene-expression programs, which contain several master transcription factors (Meis1, Pbx1, Mn1, and Lmo2) required for HSC maintenance and self-renewal...
  20. Boer J, den Boer M. BCR-ABL1-like acute lymphoblastic leukaemia: From bench to bedside. Eur J Cancer. 2017;82:203-218 pubmed publisher
    ..fusions are mutually exclusive with the sentinel translocations in BCP-ALL (BCR-ABL1, ETV6-RUNX1, TCF3-PBX1, and KMT2A (MLL) rearrangements) and have the promising prospect to be sensitive to tyrosine kinase inhibitors ..
  21. Kocabas F, Xie L, Xie J, Yu Z, DeBerardinis R, Kimura W, et al. Hypoxic metabolism in human hematopoietic stem cells. Cell Biosci. 2015;5:39 pubmed publisher
    ..Finally, we show that Meis1 and its cofactors Pbx1 and HoxA9 play an important role in transcriptional activation of Hif-1α in a cooperative manner...
  22. Jackson B, Brown S, Avilion A, O Shaughnessy R, Sully K, Akinduro O, et al. TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier. J Cell Sci. 2011;124:1681-90 pubmed publisher
    ..g. tongue). We demonstrate here that a complex of TALE homeobox transcription factors PBX1, PBX2 and Pknox (homologues of Drosophila Extradenticle and Homothorax) preferentially regulate external rather ..
  23. Groves J, Gillman C, DeLay C, Kroll T. Identification of Novel Binding Partners for Transcription Factor Emx2. Protein J. 2019;38:2-11 pubmed publisher
    ..Although several binding partners for Emx2 have been identified (including Sp8, eIF4E, and Pbx1), no screens have been used to identify potential protein binding partners for this protein...
  24. Yoachim S, Nuxoll J, Bynoté K, Gould K. Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice. Clin Immunol. 2015;158:153-66 pubmed publisher
    ..Sle1 females. Thus, estrogens, acting via ERα, control sex bias in the Sle1 phenotype. Furthermore, we show that ERα may impact the Sle1 phenotype by modulating the expression of Pbx1, one of genes that underlies the Sle1 locus.
  25. Demerath E, Guan W, Grove M, Aslibekyan S, Mendelson M, Zhou Y, et al. Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci. Hum Mol Genet. 2015;24:4464-79 pubmed publisher
    ..in lipid metabolism, immune response/cytokine signaling and other diverse pathways, including LGALS3BP, KDM2B, PBX1 and BBS2, among others...
  26. Conway C, Mitra A, Jewell R, Randerson Moor J, Lobo S, Nsengimana J, et al. Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival. Clin Cancer Res. 2009;15:6939-46 pubmed publisher
    ..Genes whose expression correlated most strongly with osteopontin were PBX1, BIRC5 (survivin), and HLF...
  27. Chen X, Jung J, Shajahan Haq A, Clarke R, Shih I, Wang Y, et al. ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profiles. Nucleic Acids Res. 2016;44:e65 pubmed publisher
    ..We applied ChIP-BIT to find target genes from NOTCH3 and PBX1 ChIP-seq data acquired from MCF-7 breast cancer cells...
  28. Takahashi H, Kajiwara R, Kato M, Hasegawa D, Tomizawa D, Noguchi Y, et al. Treatment outcome of children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group (TCCSG) Study L04-16. Int J Hematol. 2018;108:98-108 pubmed publisher
    ..0?±?1.0%), high hyperdiploidy (95.4?±?1.6%), ETV6-RUNX1 (97.4?±?1.2%) or TCF3-PBX1 (96.9?±?2.1%), and "Day8NoBlasts" (96.4?±?1.1%) had the best outcomes...
  29. Pliner H, Packer J, McFaline Figueroa J, Cusanovich D, Daza R, Aghamirzaie D, et al. Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data. Mol Cell. 2018;71:858-871.e8 pubmed publisher
    ..A subset of elements bound by MYOD1 in myoblasts exhibit early opening in a PBX1- and MEIS1-dependent manner...
  30. Pattabiraman K, Golonzhka O, Lindtner S, Nord A, Taher L, Hoch R, et al. Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014;82:989-1003 pubmed publisher
    ..of the enhancers using informatics, in vivo occupancy by TFs that regulate cortical patterning (CoupTFI, Pax6, and Pbx1), and analysis of enhancer activity in Pax6 mutants...
  31. Omrani M, Yaqubi M, Mohammadnia A. Transcription Factors in Regulatory and Protein Subnetworks during Generation of Neural Stem Cells and Neurons from Direct Reprogramming of Non-fibroblastic Cell Sources. Neuroscience. 2018;380:63-77 pubmed publisher
    ..of centrality with active modules or protein complex analyses highlighted the role of POU3F2, BACH1, AR, PBX1, SOX2 and NANOG genes in this conversion...
  32. Liang D, Chen S, Liu H, Yang C, Yeh T, Jaing T, et al. Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B-precursor acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018;65: pubmed publisher
    ..6% vs. 80.5%, P = 0.04). None of patients with TCF3-PBX1 had KRAS mutation (P = 0.02)...
  33. Barbosa T, Terra Granado E, Quezado Magalhães I, Neves G, Gadelha A, Guedes Filho G, et al. Frequency of copy number abnormalities in common genes associated with B-cell precursor acute lymphoblastic leukemia cytogenetic subtypes in Brazilian children. Cancer Genet. 2015;208:492-501 pubmed publisher
    ..05). TCF3-PBX1 was frequently deleted in RB1, and an absence of deletions was observed in IKZF1 and genes localized to the PAR1 ..
  34. Uyguner Z, Toksoy G, Altunoglu U, Ozgur H, Basaran S, Kayserili H. A new hereditary congenital facial palsy case supports arg5 in HOX-DNA binding domain as possible hot spot for mutations. Eur J Med Genet. 2015;58:358-63 pubmed publisher
    ..It should be noted that, inclusive of the previous report, only two mutations revealed in HOXB1 associated with HCFP involved the same amino acid arg5 in HOXB1 residing in HOXB1-DNA-PBX1 ternary complex.
  35. Bayly R, Murase T, Hyndman B, Savage R, Nurmohamed S, Munro K, et al. Critical role for a single leucine residue in leukemia induction by E2A-PBX1. Mol Cell Biol. 2006;26:6442-52 pubmed
    ..cases of acute lymphoblastic leukemia, a chromosomal translocation leads to expression of the oncogenic protein E2A-PBX1. The N-terminal portion of E2A-PBX1, encoded by the E2A gene, is identical in sequence to the corresponding portion ..
  36. Duesing K, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, et al. Evaluating the association of common PBX1 variants with type 2 diabetes. BMC Med Genet. 2008;9:14 pubmed publisher
    b>PBX1 is a biological candidate gene for type 2 diabetes at the 1q21-q24 susceptibility locus. The aim of this study was to evaluate the association of common PBX1 variants with type 2 diabetes in French Caucasian subjects...
  37. Milech N, Gottardo N, Ford J, D Souza D, Greene W, Kees U, et al. MEIS proteins as partners of the TLX1/HOX11 oncoprotein. Leuk Res. 2010;34:358-63 pubmed publisher
    ..Here, we report that TLX1 and MEIS proteins both interact and are co-expressed in T-ALL, and suggest that co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis. ..
  38. Mojsin M, Stevanovic M. PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. Biochem J. 2009;425:107-16 pubmed publisher
    ..present study we provide the first evidence that the TALE (three-amino-acid loop extension) transcription factors PBX1 (pre-B-cell leukaemia homeobox 1) and MEIS1 (myeloid ecotropic viral integration site 1 homologue) participate in ..
  39. Núñez Enríquez J, Mejía Aranguré J. [Molecular biology and childhood leukemia: E2A-PBX1 and central nervous system relapse]. Rev Med Inst Mex Seguro Soc. 2015;53 Suppl 3:S236-9 pubmed
    ..One of the best studied gene rearrangements is E2A-PBX1, which predicts isolated central nervous system relapse in patients with ALL...
  40. Limsuwanachot N, Siriboonpiputtana T, Karntisawiwat K, Chareonsirisuthigul T, Chuncharunee S, Rerkamnuaychoke B. Multiplex RT-PCR Assay for Detection of Common Fusion Transcripts in Acute Lymphoblastic Leukemia and Chronic Myeloid Leukemia Cases. Asian Pac J Cancer Prev. 2016;17:677-84 pubmed
    ..RT-PCR assay for detection of the 4 most frequent translocations in ALL (BCR-ABL, TEL-AML1, MLL-AF4, and E2A- PBX1)...
  41. Magnani L, Patten D, Nguyen V, Hong S, Steel J, Patel N, et al. The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer. Oncotarget. 2015;6:21878-91 pubmed
    ..The pioneer factor PBX1 translates epigenetic cues and mediates estrogen induced ERα binding...
  42. Araki N, Ishigami T, Ushio H, Minegishi S, Umemura M, Miyagi Y, et al. Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L. Biochem Biophys Res Commun. 2009;388:290-6 pubmed publisher
    ..NPC2 might regulate sodium reabsorption in the terminal nephron by interacting with ENaC-Nedd4L system. ..
  43. Farber P, Mittermaier A. Concerted dynamics link allosteric sites in the PBX homeodomain. J Mol Biol. 2011;405:819-30 pubmed publisher
    The PBX1 homeodomain (PBX-HD) cooperatively binds DNA with Hox transcription factors and helps to regulate gene expression during vertebrate development. Allostery plays an important role in these interactions...
  44. Aït Ghezali L, Arbabian A, Roudot H, Brouland J, Baran Marszak F, Salvaris E, et al. Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation. J Exp Clin Cancer Res. 2017;36:87 pubmed publisher
    ..the pharmacologically induced differentiation of leukemic precursor B lymphoblast cell lines that carry the E2A-PBX1 fusion oncoprotein...
  45. Liu Y, MacDonald R, Swift G. DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. J Biol Chem. 2001;276:17985-93 pubmed
    ..PBX1b.MEIS2b complex cooperates with the PTF1 basic helix-loop-helix complex to activate an ELA1 minienhancer in HeLa cells and that this cooperation requires all three homeoprotein subunits, including the PDX1 activation domain. ..
  46. Chan K, Zhang J, Chia N, Chan Y, Sim H, Tan K, et al. KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. Stem Cells. 2009;27:2114-25 pubmed publisher
    ..we successfully identified a zinc finger transcription factor KLF4 and a homeodomain transcription factor PBX1 as two novel transcriptional regulators that maintain the pluripotent and undifferentiated state of hESCs...
  47. Chen D, Zheng J, Gerasimcik N, Lagerstedt K, Sjögren H, Abrahamsson J, et al. The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia. PLoS ONE. 2016;11:e0162638 pubmed publisher
    ..Moreover, analyzing six BCP-ALL data sets (n = 733), we demonstrate that TCF3-PBX1 ALL express high levels of IGHM, IGLL1 and VPREB1, and are arrested at the pre-B stage...
  48. Huang Y, Coustan Smith E, Kao H, Liu H, Chen S, Hsiao C, et al. Concordance of two approaches in monitoring of minimal residual disease in B-precursor acute lymphoblastic leukemia: Fusion transcripts and leukemia-associated immunophenotypes. J Formos Med Assoc. 2017;116:774-781 pubmed publisher
    ..lymphoblastic leukemia patients (30 with t(12;21)/ETV6-RUNX1, 16 with t(9;22)/BCR-ABL1 and nine with t(1;19)/TCF3-PBX1) were examined in tandem by RQ-PCR and six-color flow cytometry...
  49. Shen W, Krishnan K, Lawrence H, Largman C. The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol Cell Biol. 2001;21:7509-22 pubmed
  50. Liu X, Xu C, Zhang L, Huang L, Hu T, Li R, et al. PBX1 attributes as a determinant of connexin 32 downregulation in Helicobacter pylori-related gastric carcinogenesis. World J Gastroenterol. 2017;23:5345-5355 pubmed publisher
    ..pylori (-)] were collected. After transcriptional factor array analysis, the Cx32 and PBX1 expression levels of H. pylori-infected tissues from the developmental stages of GC and NGM with no H...
  51. Al Kzayer L, Sakashita K, Al Jadiry M, Al Hadad S, Ghali H, Uyen L, et al. Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2015;62:2157-61 pubmed publisher
    ..Of 57 patients with chimeric transcripts, only two patients with either TEL-AML1 or E2A-PBX1 had KRAS mutation. The frequency of NRAS mutation was four times higher than that of KRAS mutation in AML...
  52. Golonzhka O, Nord A, Tang P, Lindtner S, Ypsilanti A, Ferretti E, et al. Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015;88:1192-1207 pubmed publisher
    We demonstrate using conditional mutagenesis that Pbx1, with and without Pbx2(+/-) sensitization, regulates regional identity and laminar patterning of the developing mouse neocortex in cortical progenitors (Emx1-Cre) and in newly ..
  53. Hirabayashi S, Ohki K, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, et al. ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype. Haematologica. 2017;102:118-129 pubmed publisher
    ..features and related to that of EP300-ZNF384-positive patients, but was significantly distinct from that of TCF3-PBX1-positive and ZNF384-fusion-negative patients...
  54. Li H, Jiang L, Yu Z, Han S, Liu X, Li M, et al. The Role of a Novel Long Noncoding RNA TUC40- in Cardiomyocyte Induction and Maturation in P19 Cells. Am J Med Sci. 2017;354:608-616 pubmed publisher
    ..We established the overexpression cell model by plasmid transfection, and explored the expression profile of Pbx1, the sense gene of TUC40-, and the marker genes of cardiomyocyte linage commitment (Nkx2...
  55. He J, Chen Z, Xue Y, Li J, He H, Huang Y, et al. [Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:551-3 pubmed
    ..The patients with immunophenotype of Pre-B-ALL were found to carry: TEL/AML1(3 cases); E2A/PBX1, E2A/HLF, TLS/ERG, MLL/AF4, MLL/AF9, MLL/AF10, MLL/AFX-MLL/AF6-MLL/ELL, MLL/AF6-MLL/ELL, dupMLL (one case for each);..
  56. Shirasaki R, Tashiro H, Oka Y, Sugao T, Yamamoto T, Yoshimi M, et al. Vascular endothelial growth factor-C and its receptor type-3 expressed in acute lymphocytic leukemia cases with t(1;19). Int J Hematol. 2011;94:203-208 pubmed publisher
    ..endothelial growth factor (VEGF)-C system was analyzed in two cases of acute lymphocytic leukemia (ALL) with TCF3/PBX1 fusion to determine whether the VEGF-C system influences the growth of these ALL blasts...
  57. Mo M, Chen Z, Zhou H, Li H, Hirata T, Jablons D, et al. Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer. J Exp Clin Cancer Res. 2013;32:29 pubmed publisher
    E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on E2A-PBX1 fusion transcripts in non-small-cell lung cancer (NSCLC)...
  58. Ai X, Zhang Y, Shi X, Zheng Y, Zhang L, Wang X, et al. [Application of Combined Detection of Fusion Gene and BIOMED-2 Standardized Ig Gene Rearrangement System in Childhood B-cell Acute Lymphoblastic Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:352-7 pubmed publisher
    ..Out of 251 children with B-ALL, 77 cases were TEL-AML1(+) , 28 cases were E2A-PBX1(+) , 10 cases were MLL-AF4(+) , 11 cases were BCR-ABL(+) , the total positive rate was 50.2%, 82...
  59. Villaescusa J, Li B, Toledo E, Rivetti di Val Cervo P, Yang S, Stott S, et al. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. EMBO J. 2016;35:1963-78 pubmed publisher
    ..Here, we show that PBX1 controls a novel transcriptional network required for mDAn specification and survival, which is sufficient to ..
  60. Guerra Castillo F, Ramos Cervantes M, Rosel Pech C, Jimenez Hernandez E, Bekker Mendez V. [PCR detection of relevant translocations in pediatric acute lymphoblastic leukemia]. Rev Med Inst Mex Seguro Soc. 2016;54 Suppl 3:S302-S308 pubmed
    ..The aim of this work is to detect the molecular alterations: TEL-AML1, MLL-AF4, BCR-ABL minor and E2A-PBX1 in pediatric patients with acute lymphoblastic leukemia...
  61. Shen W, Rozenfeld S, Kwong A, Köm ves L, Lawrence H, Largman C. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. Mol Cell Biol. 1999;19:3051-61 pubmed
    ..Taken together, these data suggest that in myeloid leukemia cells MEIS1 forms trimeric complexes with PBX and HOXA9, which in turn can bind to consensus PBX-HOXA9 DNA targets. ..
  62. Ferretti E, Marshall H, Popperl H, Maconochie M, Krumlauf R, Blasi F. Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Development. 2000;127:155-66 pubmed
  63. Ota T, Asahina H, Park S, Huang Q, Minegishi T, Auersperg N, et al. HOX cofactors expression and regulation in the human ovary. Reprod Biol Endocrinol. 2008;6:49 pubmed publisher
    ..In this study, the expression of HOX cofactors, PBX1, PBX2, and MEIS1/2, were examined by using RT-PCR, immunofluorescence in cultured immortalized human granulosa (..
  64. Martinez Mancilla M, Rodriguez Aguirre I, Tejocote Romero I, Medina Sanson A, Ocadiz Delgado R, Gariglio P. Clinical relevance of the fusion transcripts distribution pattern in mexican children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2013;35:170-3 pubmed publisher
    ..001). Most notable observation was identified a significant number of e2a-pbx1-positive patients who showed a more aggressive disease at diagnosis...
  65. Jerchel I, Hoogkamer A, Ariës I, Steeghs E, Boer J, Besselink N, et al. RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia. Leukemia. 2017;: pubmed publisher
    ..and B-other cases (50-70%), whereas mutations were less frequent in ETV6-RUNX1-rearranged, and rare in TCF3-PBX1- and BCR-ABL1-rearranged cases (27-4%)...
  66. Lu Q, Kamps M. Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. Mol Cell Biol. 1996;16:1632-40 pubmed
    Genetic studies have identified a family of divergent homeodomain proteins, including the human protooncoprotein Pbx1 and its drosophila homolog extradenticle (Exd), which function as cofactors with a subset of Hox and HOM-C proteins, and ..
  67. Berthelsen J, Zappavigna V, Mavilio F, Blasi F. Prep1, a novel functional partner of Pbx proteins. EMBO J. 1998;17:1423-33 pubmed
    ..Heterodimerization of Prep1 and Pbx results in a strong DNA binding affinity towards the TGACAG target site of the uPA promoter. Overall, these data indicate that Prep1 is a stable intracellular partner of Pbx in vivo. ..
  68. Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, et al. Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. Blood. 2003;101:4748-56 pubmed
    ..Thus, these studies demonstrate that the homeodomain proteins, MEIS1, PBX1B, and PBX2, play an important role in megakaryocytic gene expression. ..
  69. Debril M, Gelman L, Fayard E, Annicotte J, Rocchi S, Auwerx J. Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. J Biol Chem. 2004;279:16677-86 pubmed
    ..In conclusion, BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI/SNF complex is recruited to nuclear receptors and other transcription factors. ..
  70. Muharram G, Beucher A, Moerman E, Belaich S, Gmyr V, Vandewalle B, et al. Endocrine pancreatic tissue plasticity in obese humans is associated with cytoplasmic expression of PBX-1 in pancreatic ductal cells. Biochem Biophys Res Commun. 2005;333:1153-9 pubmed
    ..cDNA microarray analysis also showed up-regulation of other genes implicated in islet regeneration, including betacellulin, laminin, TGFa, NeuroD1, Pax6, substantiating the role of the islet neogenesis pathway in human obesity. ..
  71. Ferraz de Souza B, Martin F, Mallet D, Hudson Davies R, Cogram P, Lin L, et al. CBP/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 2, and pre-B-cell leukemia transcription factor 1 in human adrenal development and disease. J Clin Endocrinol Metab. 2009;94:678-83 pubmed publisher
    ..transactivator, with Glu/Asp-rich C-terminal domain, 2 (CITED2), and pre-B-cell leukemia transcription factor 1 (PBX1), in human adrenal development and disease...
  72. Shimabe M, Goyama S, Watanabe Okochi N, Yoshimi A, Ichikawa M, Imai Y, et al. Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. Oncogene. 2009;28:4364-74 pubmed publisher
    ..In this study, we identified Pbx1, a proto-oncogene in hematopoietic malignancy, as a target gene of Evi-1...
  73. McCarthy V, Ott C, Phylactides M, Harris A. Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression. Biochim Biophys Acta. 2009;1789:709-18 pubmed publisher
    ..We demonstrate that though sequences within these DHS bind HNF1, CDX2, and PBX1 in vitro, only PBX1 show a robust in vivo interaction...
  74. Cuda C, Li S, Liang S, Yin Y, Potula H, Xu Z, et al. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol. 2012;188:604-14 pubmed publisher
    ..At the molecular level, Sle1a.1 corresponds to an increased expression of a novel splice isoform of Pbx1, Pbx1-d...
  75. Ma W, Li Y, Wang M, Li H, Su T, Li Y, et al. Associations of Polymorphisms in WNT9B and PBX1 with Mayer-Rokitansky-Küster-Hauser Syndrome in Chinese Han. PLoS ONE. 2015;10:e0130202 pubmed publisher
    ..Seventeen candidate loci in the AMH, PBX1, WNT4, WNT7A, WNT9B, HOXA10, HOXA11, LHXA1 and GALT genes were genotyped using the Sequenom MassARRAY iPLEX ..
  76. Choi S, Hutchinson T, Titov A, Seay H, Li S, Brusko T, et al. The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation. J Immunol. 2016;197:458-69 pubmed publisher
    b>Pbx1 controls chromatin accessibility to a large number of genes and is entirely conserved between mice and humans. The Pbx1-d dominant-negative isoform is more frequent in CD4(+) T cells from lupus patients than from healthy controls...
  77. Wang J, Shidfar A, Ivancic D, Ranjan M, Liu L, Choi M, et al. Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer. Int J Cancer. 2017;140:2484-2497 pubmed publisher
    ..examine LiMe gene expression in both tumor and CUB, and investigate the role of Pre-B-cell leukemia homeobox-1 (PBX1) as a candidate common transcription factor for LiMe gene expression...
  78. Mikkola I, Bruun J, Holm T, Johansen T. Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins. J Biol Chem. 2001;276:4109-18 pubmed
    ..Since many homeodomain proteins are coexpressed with Pax6 in several tissues during development, our results indicate the existence of novel regulatory interactions that may be important for fine tuning of gene regulation. ..
  79. Qiu Y, Tomita Y, Zhang B, Nakamichi I, Morii E, Aozasa K. Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth. Am J Pathol. 2007;170:152-9 pubmed
    ..The deletion and mutation at the two binding motifs for pre-B-cell leukemia transcription factor 1 (PBX1) reduced the luciferase activity, indicating that these two PBX1 motifs mediated the transactivation of the VCP ..
  80. Horman S, Velu C, Chaubey A, Bourdeau T, Zhu J, Paul W, et al. Gfi1 integrates progenitor versus granulocytic transcriptional programming. Blood. 2009;113:5466-75 pubmed publisher
    ..We demonstrate that Gfi1 directly represses HoxA9, Pbx1, and Meis1 during normal myelopoiesis...
  81. Argiropoulos B, Yung E, Xiang P, Lo C, Kuchenbauer F, Palmqvist L, et al. Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3. Blood. 2010;115:4071-82 pubmed publisher
    ..This study provides strong evidence linking the growth-promoting activities of Meis1 to the cyclin D-pRb cell-cycle control pathway...
  82. Gabriel A, Lafta F, Schwalbe E, Nakjang S, Cockell S, Iliasova A, et al. Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia. Epigenetics. 2015;10:717-26 pubmed publisher
    ..carried out on 52 diagnostic patient samples from 4 genetic subtypes [ETV6-RUNX1, high hyperdiploidy (HeH), TCF3-PBX1 and dic(9;20)(p11-13;q11)] in a 1:1 case-control design with patients who went on to relapse (as cases) and ..
  83. Xu X, Han K, Tang X, Zeng Y, Lin X, Zhao Y, et al. The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1. J Biol Chem. 2016;291:9617-28 pubmed publisher
    ..between -144 and -99 upstream of the RNF6 transcription start site was critical and that this region contained a PBX1 recognition element (PRE). PBX1 modulated RNF6 expression by binding to the specific PRE...
  84. van Dijk M, Voorhoeve P, Murre C. Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1993;90:6061-5 pubmed
    ..3) chromosomal translocation. This translocation joins the 5' region of the E2A gene to the 3' region of the Pbx1 gene...
  85. Dintilhac A, Bihan R, Guerrier D, Deschamps S, Pellerin I. A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis. Gene Expr Patterns. 2004;4:215-22 pubmed
    ..We further found that both isoforms are able to interact with CBP, suggesting a competition between Hoxa9 and Hoxa9T with this protein. ..
  86. Bayly R, Chuen L, Currie R, Hyndman B, Casselman R, Blobel G, et al. E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. J Biol Chem. 2004;279:55362-71 pubmed
    ..in a chromosomal translocation that leads to the expression of an oncogenic transcription factor called E2A-PBX1 in cases of acute leukemia...
  87. Bjerke G, Hyman Walsh C, Wotton D. Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. Mol Cell Biol. 2011;31:3723-33 pubmed publisher
    ..We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or GC ..
  88. He C, Wang Z, Zhang L, Yang L, Li J, Chen X, et al. A hydrophobic residue in the TALE homeodomain of PBX1 promotes epithelial-to-mesenchymal transition of gastric carcinoma. Oncotarget. 2017;8:46818-46833 pubmed publisher
    Pre-B-cell leukemia homeobox 1 (PBX1) was originally identified as a proto-oncogene in human leukemia...
  89. Lu Q, Wright D, Kamps M. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol Cell Biol. 1994;14:3938-48 pubmed
    E2A-PBX1 is a chimeric gene formed by the t(1;19)(q23;p13.3) chromosomal translocation of pediatric pre-B-cell leukemia...
  90. Sera Y, Yamasaki N, Oda H, Nagamachi A, Wolff L, Inukai T, et al. Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia. Cancer Sci. 2016;107:890-8 pubmed publisher
    E2A-PBX1 is a chimeric gene product detected in t(1;19)-bearing acute lymphoblastic leukemia (ALL) with B-cell lineage...
  91. Grebbin B, Hau A, Groß A, Anders Maurer M, Schramm J, Koss M, et al. Pbx1 is required for adult subventricular zone neurogenesis. Development. 2016;143:2281-91 pubmed publisher
    ..Expression of the PBC protein PBX1 in the SVZ has been reported, but its functional role(s) has not been investigated...
  92. Subramaniam N, Campion J, Rafter I, Okret S. Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1. Biochem J. 2003;370:1087-95 pubmed
    ..RA-induced expression of the murine Hoxb -1 gene through an autoregulatory element, b1-ARE, recognized by the Pbx1 and HOXB1 homoeodomain proteins...