PBRM1

Summary

Gene Symbol: PBRM1
Description: polybromo 1
Alias: BAF180, PB1, protein polybromo-1, BRG1-associated factor 180, polybromo-1D
Species: human
Products:     PBRM1

Top Publications

  1. Yan Z, Cui K, Murray D, Ling C, Xue Y, Gerstein A, et al. PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Genes Dev. 2005;19:1662-7 pubmed
    ..selectivity by PBAF requires a novel subunit, BAF200, but not the previously described PBAF-specificity subunit, BAF180 (Polybromo)...
  2. Kapur P, Peña Llopis S, Christie A, Zhrebker L, Pavía Jiménez A, Rathmell W, et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation. Lancet Oncol. 2013;14:159-167 pubmed publisher
    ..We discovered that BAP1 is mutated in about 15% of clear-cell renal-cell carcinoma, and that BAP1 and PBRM1 mutations are largely mutually exclusive...
  3. Xue Y, Canman J, Lee C, Nie Z, Yang D, Moreno G, et al. The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. Proc Natl Acad Sci U S A. 2000;97:13015-20 pubmed
    ..It contains six components conserved in both Rsc and SWI/SNF. Importantly, it has a unique subunit, BAF180, that harbors a distinctive set of structural motifs characteristic of three components of Rsc...
  4. Xia W, Nagase S, Montia A, KALACHIKOV S, Keniry M, Su T, et al. BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res. 2008;68:1667-74 pubmed publisher
    ..for tumor suppressor genes in breast cancer revealed multiple truncating mutations of PB1, which encodes the BAF180 subunit of the PBAF chromatin remodeling complex...
  5. Burrows A, Smogorzewska A, Elledge S. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A. 2010;107:14280-5 pubmed publisher
    ..Here we describe BRD7 and BAF180 as unique regulators of replicative senescence in human cells...
  6. Lemon B, Inouye C, King D, Tjian R. Selectivity of chromatin-remodelling cofactors for ligand-activated transcription. Nature. 2001;414:924-8 pubmed
    ..These studies demonstrate functional selectivity amongst highly related complexes involved in gene regulation and help define a more complete set of factors and cofactors required to activate transcription. ..
  7. Varela I, Tarpey P, Raine K, Huang D, Ong C, Stephens P, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature. 2011;469:539-42 pubmed publisher
    ..exome in a series of primary ccRCC and report the identification of the SWI/SNF chromatin remodelling complex gene PBRM1 (ref. 4) as a second major ccRCC cancer gene, with truncating mutations in 41% (92/227) of cases...
  8. da Costa W, Rezende M, Carneiro F, Rocha R, da Cunha I, Carraro D, et al. Polybromo-1 (PBRM1), a SWI/SNF complex subunit is a prognostic marker in clear cell renal cell carcinoma. BJU Int. 2014;113:E157-63 pubmed publisher
    ..immunohistochemical and mRNA expression of SWI/SNF (SWItch/Sucrose NonFermentable) complex subunit polybromo-1 (PBRM1) in clear cell renal cell carcinoma (ccRCC) and its impact on clinical outcomes...
  9. Chandrasekaran R, Thompson M. Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions. Biochem Biophys Res Commun. 2007;355:661-6 pubmed
    ..Identification of duplicate target sites suggests that native Pb1 interacts with both copies of histone H3 upon nucleosome assembly...

More Information

Publications126 found, 100 shown here

  1. Jiao Y, Pawlik T, Anders R, Selaru F, Streppel M, Lucas D, et al. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet. 2013;45:1470-1473 pubmed publisher
    ..we discovered frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1, ARID1A and PBRM1), and mutation in one of these genes occurred in almost half of the carcinomas sequenced...
  2. Peter Ross E. Molecular hypotheses to explain the shared pathways and underlying pathobiological causes in catatonia and in catatonic presentations in neuropsychiatric disorders. Med Hypotheses. 2018;113:54-64 pubmed publisher
    ..SNORD115 controls five genes CRHR1, PBRM1, TAF1, DPM2, and RALGPS1 as well as the alternative splicing of serotonin 2C receptor...
  3. Liu L, Wan X, Zhou P, Zhou X, Zhang W, Hui X, et al. The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis. J Hematol Oncol. 2018;11:27 pubmed publisher
    ..Several subunits of BAF or PBAF, including BRG1, BAF53a, BAF45a, BAF180, and BAF250a, are known to be involved in hematopoiesis...
  4. Zhou B, Meliopoulos V, Wang W, Lin X, Stucker K, Halpin R, et al. Reversion of Cold-Adapted Live Attenuated Influenza Vaccine into a Pathogenic Virus. J Virol. 2016;90:8454-63 pubmed publisher
    ..Sequencing of the variant identified seven nonsynonymous mutations, PB1-E51K, PB1-I171V, PA-N350K, PA-L366I, NP-N125Y, NP-V186I, and NS2-G63E...
  5. Choi J, Jin Y, Lee H, Oh T, Yim N, Cho W, et al. Protective Effect of Panax notoginseng Root Water Extract against Influenza A Virus Infection by Enhancing Antiviral Interferon-Mediated Immune Responses and Natural Killer Cell Activity. Front Immunol. 2017;8:1542 pubmed publisher
    ..In addition, PNR pretreatment inhibited viral protein (PB1, PB2, HA, NA, M1, PA, M2, and NP) and viral mRNA (NS1, HA, PB2, PA, NP, M1, and M2) expression...
  6. Peixoto M, Domingues A, Batista S, Gonçalves J, Gomes A, Cunha S, et al. Physiopathological responses of sole (Solea senegalensis) subjected to bacterial infection and handling stress after probiotic treatment with autochthonous bacteria. Fish Shellfish Immunol. 2018;83:348-358 pubmed publisher
    ..diet (CTRL, without the dietary probiotic supplementation), and five diets supplemented with probiotic bacteria: PB1 (Shewanella hafniensis), PB2 (Enterococcus raffinosus), PB3 (Shewanella hafniensis + Arthrobacter soli), PB4 (..
  7. Shi C, Pan B, Shi F, Xie Z, Jiang Y, Shang L, et al. Sequestosome 1 protects esophageal squamous carcinoma cells from apoptosis via stabilizing SKP2 under serum starvation condition. Oncogene. 2018;37:3260-3274 pubmed publisher
    ..Through interaction with the domains PB1, p62 upregulated the expression of PKCiota and then depressed the ubiquitin-mediated proteasomal degradation of ..
  8. York A, Hutchinson E, Fodor E. Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication. J Virol. 2014;88:13284-99 pubmed publisher
    ..When this tagged subunit was purified from infected cells, copurifying proteins included the other RdRP subunits (PB1 and PA) and the viral nucleoprotein and neuraminidase, as well as 171 cellular proteins...
  9. Yeh Y, Chang C, Lee P, Cheng W. The transcription of atypical protein kinase C in hemocytes of the giant freshwater prawn, Macrobrachium rosenbergii, during the molt stage and injection of pathogen-associated compounds. Fish Shellfish Immunol. 2017;69:52-58 pubmed publisher
    ..its protein comprised structural domains similar to those of atypical PKC homologues, including the Phox and Bem1 (PB1) domain, a zinc finger phorbol-ester/DAG-type signature, protein kinase signatures, and a cAMP-dependent, cGMP-..
  10. Tabynov K, Sansyzbay A, Sandybayev N, Mambetaliyev M. The pathogenicity of swan derived H5N1 virus in birds and mammals and its gene analysis. Virol J. 2014;11:207 pubmed publisher
    ..mice, guinea pigs, cats, dogs, pigs), and identified the molecular determinants of virulence in 11 genes (HA, NA, PB1, PB1-F2, PB2, PA, NS1, NS2, M1, M2 and NP)...
  11. Kirui J, Mondal A, Mehle A. Ubiquitination Upregulates Influenza Virus Polymerase Function. J Virol. 2016;90:10906-10914 pubmed publisher
    ..It is a trimeric complex composed of subunits PA, PB1, and PB2 and associates with viral RNAs and nucleoprotein (NP) to form higher-order ribonucleoprotein (RNP) ..
  12. Bae J, Lee I, Kim J, Park S, Yoo K, Park M, et al. A Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses. J Virol. 2018;92: pubmed publisher
    ..Several amino acid mutations were identified in the PB2, PB1, PA, BM2, and/or NS1 protein-coding regions, and one concurrent lysine (K)-to-arginine (R) mutation in PA residue ..
  13. Bertran K, Lee D, Pantin Jackwood M, Spackman E, Balzli C, Suarez D, et al. Pathobiology of Clade 2.3.4.4 H5Nx High-Pathogenicity Avian Influenza Virus Infections in Minor Gallinaceous Poultry Supports Early Backyard Flock Introductions in the Western United States in 2014-2015. J Virol. 2017;91: pubmed publisher
    ..in all genes and species, but especially in Japanese quail and pearl guinea fowl and in internal proteins PB1 and PB2...
  14. Wan Z, Cardenas Garcia S, Liu J, Santos J, Carnaccini S, Geiger G, et al. Alternative Strategy for a Quadrivalent Live Attenuated Influenza Virus Vaccine. J Virol. 2018;92: pubmed publisher
    ..Previously, we developed a combined strategy of temperature-sensitive mutations in the PB2 and PB1 segments and an epitope tag in the C terminus of PB1 that effectively attenuates influenza A viruses of avian and ..
  15. Liu Z, Lian B, Dong Q, Sun H, Wei J, Sheng Y, et al. Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2360-2368 pubmed publisher
    ..TP53 and CTNNB1 were identified as exhibiting mutations in CHC. ARID1A, PBRM1, and IDH1 were frequently mutated in ICC...
  16. Wahl A, Schafer F, Bardet W, Buchli R, Air G, Hildebrand W. HLA class I molecules consistently present internal influenza epitopes. Proc Natl Acad Sci U S A. 2009;106:540-5 pubmed publisher
    ..from the internal viral nucleoprotein (NP(418-426) and NP(473-481)) and from the internal viral polymerase subunit PB1 (PB1(329-337)) were presented by B*0702 following infection with each of 3 different influenza strains; ligands NP(..
  17. Batts W, LaPatra S, Katona R, Leis E, Ng T, Brieuc M, et al. Molecular characterization of a novel orthomyxovirus from rainbow and steelhead trout (Oncorhynchus mykiss). Virus Res. 2017;230:38-49 pubmed publisher
    ..with orthologs from representatives of the established orthomyxoviral genera and a phylogenetic analysis using the PB1 protein showed that while RbtOV and SttOV clustered most closely with ISAV, they diverged sufficiently to merit ..
  18. Weber A, Dam S, Saul V, Kuznetsova I, Müller C, Fritz Wolf K, et al. Phosphoproteome analysis of cells infected with adapted and non-adapted influenza A virus reveals novel pro- and antiviral signaling networks. J Virol. 2019;: pubmed publisher
    ..the functional analysis of selected phosphorylation sites showed that they either support (NA Ser178) or inhibit (PB1 Thr223) virus propagation...
  19. Xu Y, Ramey A, Bowman A, DeLiberto T, Killian M, Krauss S, et al. Low-Pathogenic Influenza A Viruses in North American Diving Ducks Contribute to the Emergence of a Novel Highly Pathogenic Influenza A(H7N8) Virus. J Virol. 2017;91: pubmed publisher
    ..Preceding the outbreak, an isolate with six gene segments (PB2, PB1, PA, HA, NA, and NS) sharing >99% sequence identity with those of H7N8 turkey isolates was recovered from a ..
  20. Kato Y, Tanokura M, Kuzuhara T. NMR spectra of PB2 627, the RNA-binding domain in influenza A virus RNA polymerase that contains the pathogenicity factor lysine 627, and improvement of the spectra by small osmolytes. Biochem Biophys Rep. 2017;12:129-134 pubmed publisher
    ..The polymerase is comprised of the subunits PA, PB1, and PB2...
  21. Su W, Hsu S, Lee Y, Jeng K, Lai M. A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription. J Virol. 2015;89:11245-55 pubmed publisher
    ..transcription, which is carried out by the viral RNA-dependent RNA polymerase (RdRp), consisting of the viral PA, PB1, and PB2 proteins. However, how the viral RdRp utilizes cellular factors for virus transcription is not clear...
  22. Yamayoshi S, Watanabe M, Goto H, Kawaoka Y. Identification of a Novel Viral Protein Expressed from the PB2 Segment of Influenza A Virus. J Virol. 2016;90:444-56 pubmed publisher
    ..the RIG-I-dependent interferon signaling pathway, and interfered with viral polymerase activity (dependent on its PB1-binding capability)...
  23. Calvo E, Schmidinger M, Heng D, Grünwald V, Escudier B. Improvement in survival end points of patients with metastatic renal cell carcinoma through sequential targeted therapy. Cancer Treat Rev. 2016;50:109-117 pubmed publisher
    ..with mRCC might be based on genomic classification, especially of the 4 most commonly mutated genes in RCC (VHL, PBRM1, BAP1, and SETD2)...
  24. Zhang Y, Zou S, Li X, Dong L, Bo H, Gao R, et al. Detection of reassortant avian influenza A (H11N9) virus in environmental samples from live poultry markets in China. Infect Dis Poverty. 2016;5:59 pubmed publisher
    ..The HA, NA, M, NS and PA genes were similar to virus isolates from ducks, and the NP, PB2 and PB1 gene segments were most similar to those viruses from wild birds, indicating that the H11N9 viruses might represent ..
  25. Keskin D, REINHOLD B, Zhang G, Ivanov A, Karger B, Reinherz E. Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity. Proc Natl Acad Sci U S A. 2015;112:2151-6 pubmed publisher
    ..5 for M13-11 to a high of >500 for M1(58-66) with PA, HA, PB1, PB2, and NA epitopes also detected...
  26. Sreenivasan C, Jandhyala S, Luo S, Hause B, Thomas M, Knudsen D, et al. Phylogenetic Analysis and Characterization of a Sporadic Isolate of Equine Influenza A H3N8 from an Unvaccinated Horse in 2015. Viruses. 2018;10: pubmed publisher
    ..A BLASTn search revealed that the polymerase basic protein 1 (PB1), polymerase acidic (PA), hemagglutinin (HA), nucleoprotein (NP), and matrix (M) segments of this H3N8 isolate ..
  27. Bacharach E, Mishra N, Briese T, Zody M, Kembou Tsofack J, Zamostiano R, et al. Characterization of a Novel Orthomyxo-like Virus Causing Mass Die-Offs of Tilapia. MBio. 2016;7:e00431-16 pubmed publisher
    ..The largest segment, segment 1, contains an open reading frame with weak sequence homology to the influenza C virus PB1 subunit...
  28. Ver L, Marcos Villar L, Landeras Bueno S, Nieto A, Ortín J. The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication. J Virol. 2015;89:10023-30 pubmed publisher
    ..The viral polymerase responsible for these processes is a protein complex composed of the PB1, PB2, and PA proteins...
  29. Matsuzaki Y, Sugawara K, Furuse Y, Shimotai Y, Hongo S, Oshitani H, et al. Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014. J Virol. 2016;90:8251-65 pubmed publisher
    ..contain both antigenic and genetic lineages of the hemagglutinin-esterase (HE) gene, and the internal genes PB2, PB1, P3, NP, M, and NS are divided into two major lineages, a C/Mississippi/80-related lineage and a C/Yamagata/81-..
  30. Dong L, Shi Y, Ma L, Yang L, Wang X, Zhang S, et al. Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma. J Hepatol. 2018;69:89-98 pubmed publisher
    ..Many truncal and clonal driver mutations occurred in tumor suppressor genes, such as TP53, SMARCB1 and PBRM1 that are involved in DNA repair and chromatin-remodeling...
  31. Lin J, Xia J, Zhang T, Zhang K, Yang Q. Genome-wide profiling of microRNAs reveals novel insights into the interactions between H9N2 avian influenza virus and avian dendritic cells. Oncogene. 2018;37:4562-4580 pubmed publisher
    ..but also suggested that gga-miR6675 targets the nuclear localisation sequence of polymerase basic protein 1 (PB1) to trigger the silencing of PB1 genes, resulting in the inhibition of H9N2 AIV replication...
  32. Anaya M, Correa Baena J, Lozano G, Saliba M, Anguita P, Roose B, et al. Optical analysis of CH3NH3Sn x Pb1-x I3 absorbers: a roadmap for perovskite-on-perovskite tandem solar cells. J Mater Chem A Mater. 2016;4:11214-11221 pubmed
    ..We foresee that this study will encourage the research on novel near-infrared perovskite materials for photovoltaic applications, which may have implications in the rapidly emerging field of tandem devices. ..
  33. Sun Y, Wang X, Li X, Zhang L, Li H, Lu C, et al. Novel triple-reassortant H1N1 swine influenza viruses in pigs in Tianjin, Northern China. Vet Microbiol. 2016;183:85-91 pubmed publisher
    ..Phylogenetic analysis showed that these novel viruses contained genes from the 2009 pandemic H1N1 (PB2, PB1, PA and NP), Eurasian swine (HA, NA and M) and triple-reassortant swine (NS) lineages...
  34. Naito T, Mori K, Ushirogawa H, Takizawa N, Nobusawa E, Odagiri T, et al. Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain. J Virol. 2017;91: pubmed publisher
    ..a high-fidelity and high-growth influenza vaccine master virus strain with a single V43I amino acid change in the PB1 polymerase of the high-growth A/Puerto Rico/8/1934 (PR8) master virus...
  35. Winckelmann D, Bleeke F, Bergmann P, Klock G. Growth of Cyanobacterium aponinum influenced by increasing salt concentrations and temperature. 3 Biotech. 2015;5:253-260 pubmed publisher
    ..It was identified as Cyanobacterium aponinum PB1 and is a possible lipid source...
  36. Massari S, Desantis J, Nannetti G, Sabatini S, Tortorella S, Goracci L, et al. Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives. Org Biomol Chem. 2017;15:7944-7955 pubmed publisher
    ..of a set of compounds based on the [1,2,4]triazolo[1,5-a]pyrimidine scaffold led to the identification of compound 20 endowed with a very promising ability to inhibit influenza virus RNA polymerase PA-PB1 subunit heterodimerization.
  37. Lo C, Li O, Tang W, Hu C, Wang G, Ngo J, et al. Identification of influenza polymerase inhibitors targeting C-terminal domain of PA through surface plasmon resonance screening. Sci Rep. 2018;8:2280 pubmed publisher
    ..The influenza polymerase with three proteins, PA, PB1 and PB2, is a crucial component of the viral ribonucleoprotein (RNP) complex...
  38. Burke R, Berk B. The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease. Antioxid Redox Signal. 2015;22:1243-56 pubmed publisher
    There are a limited number of proteins containing the Phox-Bem1 (PB1) protein interaction domain, and almost all of them play some role in endothelial cell (EC) function, health, and homeostasis...
  39. Liu B, Fang M, He Z, Cui D, Jia S, Lin X, et al. Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation. Cell Death Dis. 2015;6:e1980 pubmed publisher
    ..HBx associates with the UBA and PB1 domains of the adaptor protein p62 and augments the interaction between p62 and the Nrf2 repressor Keap1 to form ..
  40. Togo Y, Yoshikawa Y, Suzuki T, Nakano Y, Kanematsu A, Zozumi M, et al. Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma. Int J Oncol. 2016;48:1571-80 pubmed publisher
    ..Additionally, we analyzed the sequences of the VHL, PBRM1, and SETD2 genes, and examined promoter methylation of VHL...
  41. Vidy A, Maisonnasse P, Da Costa B, Delmas B, Chevalier C, Le Goffic R. The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition. PLoS ONE. 2016;11:e0165361 pubmed publisher
    The influenza A virus (IAV) PB1-F2 protein is a virulence factor contributing to the pathogenesis observed during IAV infections in mammals...
  42. Hee K, Leaw Y, Ong J, Lee L. Development and validation of liquid chromatography tandem mass spectrometry method quantitative determination of polymyxin B1, polymyxin B2, polymyxin B3 and isoleucine-polymyxin B1 in human plasma and its application in clinical studies. J Pharm Biomed Anal. 2017;140:91-97 pubmed publisher
    ..Commercial formulations of PB contain multiple structurally related components with major constituents of PB1, PB2, PB3 and ile-PB1...
  43. Ghosh S, Kanwar P, Jha G. Identification of candidate pathogenicity determinants of Rhizoctonia solani AG1-IA, which causes sheath blight disease in rice. Curr Genet. 2018;64:729-740 pubmed publisher
    ..solani (strain BRS1) genes to be commonly upregulated in three different rice genotypes (PB1, Tetep, and TP309) at establishment and necrotrophic phase, respectively...
  44. Bajpai R, Chen D, Rada Iglesias A, Zhang J, Xiong Y, Helms J, et al. CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature. 2010;463:958-62 pubmed publisher
  45. Martelli F, Salata C, Calistri A, Parolin C, Azzi A, Palù G, et al. Small RNAs targeting the 5' end of the viral polymerase gene segments specifically interfere with influenza type A virus replication. J Biotechnol. 2015;210:85-90 pubmed publisher
    ..To this end, lentiviral vectors expressing either microRNAs or antisense-RNAs targeting the 5' end of the PA, PB1 and PB2 influenza virus genomic sequences were generated...
  46. Feng X, Wang Z, Shi J, Deng G, Kong H, Tao S, et al. Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice. J Virol. 2016;90:1872-9 pubmed publisher
    ..We found that the PB1 gene of the DK/08 virus dramatically attenuated the virulence of the CK/09 virus and that the amino acid at ..
  47. Guan P, Ripoll J, Wang R, Vuong L, Bailey Steinitz L, Ye D, et al. Interacting TCP and NLP transcription factors control plant responses to nitrate availability. Proc Natl Acad Sci U S A. 2017;114:2419-2424 pubmed publisher
    ..Regions of these proteins necessary for these interactions were found to include the type I/II Phox and Bem1p (PB1) domains of NLP6&7, a protein-interaction module conserved in animals for nutrient signaling, and the histidine-..
  48. Huang L, Hou Q, Ye L, Yang Q, Yu Q. Crosstalk between H9N2 avian influenza virus and crypt-derived intestinal organoids. Vet Res. 2017;48:71 pubmed publisher
    ..The HA, NA, NP and PB1 genes of H9N2 viruses could be detected in intestinal organoids at 1 h, and reached peak levels at 48 h post-..
  49. Lampis A, Carotenuto P, Vlachogiannis G, Cascione L, Hedayat S, Burke R, et al. MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma. Gastroenterology. 2018;154:1066-1079.e5 pubmed publisher
    ..Cells with IDH1 and PBRM1 mutations had the highest level of sensitivity to histone deacetylase inhibitors...
  50. Jiang W, Dulaimi E, Devarajan K, Parsons T, Wang Q, Liao L, et al. Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma. PLoS ONE. 2016;11:e0164554 pubmed publisher
    ..To address this question, we examined the protein expression of PBRM1, and PBRM1-related proteins such as ARID1A, SETD2, BRG1, and BRM...
  51. Yang C, Li H, Shiu Y, Ku T, Wang C, Tu Y, et al. Influenza A virus upregulates PRPF8 gene expression to increase virus production. Arch Virol. 2017;162:1223-1235 pubmed publisher
    ..Among the different viral proteins, expression of either the viral NS1 or PB1 gene could upregulate the PRPF8 expression...
  52. Lin Q, Dai Q, Meng H, Sun A, Wei J, Peng K, et al. The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy. J Cell Sci. 2017;130:3839-3850 pubmed publisher
    ..Mutational analysis indicates that NEDD4 interacts with and ubiquitylates the PB1 domain of SQSTM1...
  53. Latz S, Kruttgen A, Häfner H, Buhl E, Ritter K, Horz H. Differential Effect of Newly Isolated Phages Belonging to PB1-Like, phiKZ-Like and LUZ24-Like Viruses against Multi-Drug Resistant Pseudomonas aeruginosa under Varying Growth Conditions. Viruses. 2017;9: pubmed publisher
    ..Genome analysis revealed that SL1 (65,849 bp, 91 open reading frames ORFs) belongs to PB1-like viruses, SL2 (279,696 bp, 354 ORFs) to phiKZ-like viruses and SL4 (44,194 bp, 65 ORFs) to LUZ24-like viruses...
  54. Ji C, Zhang X, Yu P. Association of protein structure, protein and carbohydrate subfractions with bioenergy profiles and biodegradation functions in modeled forage. Spectrochim Acta A Mol Biomol Spectrosc. 2016;157:265-270 pubmed publisher
    ..included: protein structure amide I group, amide II group and their ratios; protein subfractions (PA1, PA2, PB1, PB2, PC); carbohydrate fractions (CA1, CA2, CA3, CA4, CB1, CB2, CC); biodegradable and undegradable fractions of ..
  55. Wu H, Peng X, Peng X, Wu N. Amino acid substitutions involved in the adaptation of a novel highly pathogenic H5N2 avian influenza virus in mice. Virol J. 2016;13:159 pubmed
    ..Amino acid changes were identified in the MA-DK19 PB2 (E627K), PB1 (I181T), HA (A150S), NS1 (seven amino acid extension "WRNKVAD" at the C-terminal), and NS2 (E69G) proteins...
  56. Morel D, Almouzni G, Soria J, Postel Vinay S. Targeting chromatin defects in selected solid tumors based on oncogene addiction, synthetic lethality and epigenetic antagonism. Ann Oncol. 2017;28:254-269 pubmed publisher
    ..deficiencies in components of the Polycomb or SWI/SNF chromatin-remodeling complexes (including BAP1, ARID1A and PBRM1 subunits), as well as between the CREBBP and EP300 histone acetylases...
  57. Kozak R, Hattin L, Biondi M, Corredor J, Walsh S, Xue Zhong M, et al. Replication and Oncolytic Activity of an Avian Orthoreovirus in Human Hepatocellular Carcinoma Cells. Viruses. 2017;9: pubmed publisher
    ..We isolated an avian orthoreovirus (ARV-PB1), and tested it against a panel of hepatocellular carcinoma cells...
  58. Potdar V, Hinge D, Dakhave M, Manchanda A, Jadhav N, Kulkarni P, et al. Molecular detection and characterization of Influenza 'C' viruses from western India. Infect Genet Evol. 2017;54:466-477 pubmed publisher
    ..The internal gene of these viruses grouped in two lineages. The PB1, PB2, M and NS genes of the study viruses grouped with C/Yamagata/26/81 (YA81), while the P3 (PA) and NP genes ..
  59. Hamilton J, Vijayakumar G, Palese P. A Recombinant Antibody-Expressing Influenza Virus Delays Tumor Growth in a Mouse Model. Cell Rep. 2018;22:1-7 pubmed publisher
    ..an antibody during infection, an influenza virus was constructed encoding the heavy chain of an antibody on the PB1 segment and the light chain of an antibody on the PA segment...
  60. . New gene mutation implicated in renal cancer. Study findings could shed light on the intricate biology of kidney cancer. Duke Med Health News. 2011;17:6-7 pubmed
  61. Chalmers Z, Johnson A, Ali S, Frampton G, Miller V, Ross J, et al. Comprehensive Genomic Profiling of Renal Cell Carcinoma at Initial Diagnosis and Putative Local Recurrence. Eur Urol Focus. 2018;4:267-269 pubmed publisher
    ..The original tumor harbors mutations in PBRM1, while the second harbors mutations in KDM5C...
  62. Pan D, Kobayashi A, Jiang P, Ferrari de Andrade L, Tay R, Luoma A, et al. A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing. Science. 2018;359:770-775 pubmed publisher
    ..Inactivation of >100 genes-including Pbrm1, Arid2, and Brd7, which encode components of the PBAF form of the SWI/SNF chromatin remodeling ..
  63. Tsunekuni R, Yaguchi Y, Kashima Y, Yamashita K, Takemae N, Mine J, et al. Spatial transmission of H5N6 highly pathogenic avian influenza viruses among wild birds in Ibaraki Prefecture, Japan, 2016-2017. Arch Virol. 2018;163:1195-1207 pubmed publisher
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    To investigate the intratumoral heterogeneity of BAP1 and PBRM1 expression at the primary site and metastatic sites and to evaluate whether BAP1 and PBRM1 expression in metastatic sites of clear cell renal cell carcinoma (ccRCC) has ..
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    ..of tolerant cultivar, Nagina 22 (N22) and Vandana, but down-regulated in the sensitive cultivar, Pusa Basmati 1 (PB1) and IR64, during drought...
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    ..frequently mutated genes were TP53 (54%), KRAS (22%), ARID1A (13%), PIK3CA (9%), CDKN2A (8%), SMARCA4 (7%) and PBRM1, STK11, APC, RB1 (5%, respectively)...
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    ..gene and at least one out of three chromatin regulating genes BRCA1-associated protein-1 (BAP1), Polybromo-1 (PBRM1) and Set domain-containing 2 (SETD2)...
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    ..We have found that PB1-F2 derived from H7N9 activates the NLRP3 inflammasome and induces lung inflammation and cellular recruitment that ..
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    ..Multiple somatic mutations (VHL, PBRM1, SETD2, KDM5C, TP53, BAP1, PTEN, MTOR) were associated with the CLEAR score...
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    Polybromo-1 (PBRM1) is a component of the PBAF (Polybromo-associated-BRG1- or BRM-associated factors) chromatin remodeling complex and is the second most frequently mutated gene in clear-cell renal cell Carcinoma (ccRCC)...