paxillin

Summary

Gene Symbol: paxillin
Description: paxillin
Alias: paxillin, testicular tissue protein Li 134
Species: human
Products:     paxillin

Top Publications

  1. Turner C, Brown M, Perrotta J, Riedy M, Nikolopoulos S, McDonald A, et al. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. J Cell Biol. 1999;145:851-63 pubmed
    b>Paxillin is a focal adhesion adaptor protein involved in the integration of growth factor- and adhesion-mediated signal transduction pathways. Repeats of a leucine-rich sequence named paxillin LD motifs (Brown M.C., M.S. Curtis, and C.E...
  2. Azuma K, Tanaka M, Uekita T, Inoue S, Yokota J, Ouchi Y, et al. Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. Oncogene. 2005;24:4754-64 pubmed
    ..Among these proteins, the protein around 70 kDa, which was most remarkably phosphorylated, was identified as paxillin, a scaffold protein in integrin signaling...
  3. Hashimoto S, Tsubouchi A, Mazaki Y, Sabe H. Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3. J Biol Chem. 2001;276:6037-45 pubmed
    p21-activated kinases (PAKs) are implicated in integrin signalings, and have been proposed to associate with paxillin indirectly. We show here that paxillin can bind directly to PAK3...
  4. Kondo A, Hashimoto S, Yano H, Nagayama K, Mazaki Y, Sabe H. A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. Mol Biol Cell. 2000;11:1315-27 pubmed
    b>Paxillin acts as an adaptor molecule in integrin signaling. Paxillin is localized to focal contacts but seems to also exist in a relatively large cytoplasmic pool...
  5. Nishiya N, Tachibana K, Shibanuma M, Mashimo J, Nose K. Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase. Mol Cell Biol. 2001;21:5332-45 pubmed
    Hic-5 is a paxillin homologue that is localized to focal adhesion complexes. Hic-5 and paxillin share structural homology and interacting factors such as focal adhesion kinase (FAK), Pyk2/CAKbeta/RAFTK, and PTP-PEST...
  6. Brown M, Perrotta J, Turner C. Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin. Mol Biol Cell. 1998;9:1803-16 pubmed
    We have previously shown that the LIM domains of paxillin operate as the focal adhesion (FA)-targeting motif of this protein...
  7. Li D, Ding J, Wang X, Wang C, Wu T. Fibronectin promotes tyrosine phosphorylation of paxillin and cell invasiveness in the gastric cancer cell line AGS. Tumori. 2009;95:769-79 pubmed
    b>Paxillin is a central protein within the focal adhesion and serves as a critical transducer of signals from fibronectin...
  8. Rose D, Liu S, Woodside D, Han J, Schlaepfer D, Ginsberg M. Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003;170:5912-8 pubmed
    ..This form of integrin trans-regulation in T cells requires the binding of paxillin to the alpha(4) integrin cytoplasmic domain...
  9. Kasai M, Guerrero Santoro J, Friedman R, Leman E, Getzenberg R, DeFranco D. The Group 3 LIM domain protein paxillin potentiates androgen receptor transactivation in prostate cancer cell lines. Cancer Res. 2003;63:4927-35 pubmed
    b>Paxillin, a member of the group 3 subfamily of LIM domain proteins, is localized within focal adhesions and participates in a number of signal transduction pathways mobilized upon activation of cell surface receptors...

More Information

Publications63

  1. Salgia R, Li J, Lo S, Brunkhorst B, Kansas G, Sobhany E, et al. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J Biol Chem. 1995;270:5039-47 pubmed
    b>Paxillin is a 68-kDa focal adhesion protein that is phosphorylated on tyrosine residues in fibroblasts in response to transformation by v-src, treatment with platelet-derived growth factor, or cross-linking of integrins...
  2. Sanders M, Basson M. p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV. J Biol Chem. 2005;280:23516-22 pubmed
    ..We observed that collagen IV also stimulated Src-dependent phosphorylation of both paxillin Tyr31 and paxillin Tyr118...
  3. Chen D, Wang D, Wu W, Zeng Z, Luo H, Qiu M, et al. Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer. Carcinogenesis. 2013;34:803-11 pubmed publisher
    The deregulation of paxillin (PXN) has been involved in the progression and metastasis of different malignancies including colorectal cancer (CRC). miR-137 is frequently suppressed in CRC...
  4. Huang C, Rajfur Z, Borchers C, Schaller M, Jacobson K. JNK phosphorylates paxillin and regulates cell migration. Nature. 2003;424:219-23 pubmed
    ..Moreover, JNK1 phosphorylates serine 178 on paxillin, a focal adhesion adaptor, both in vitro and in intact cells...
  5. Panetti T. Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. Front Biosci. 2002;7:d143-50 pubmed
    ..This review focuses on three of the cytoskeletal components of the focal adhesion, paxillin, FAK, and p130CAS, that are phosphorylated and play a regulatory role in cell spreading and cell migration...
  6. Han J, Liu S, Rose D, Schlaepfer D, McDonald H, Ginsberg M. Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. J Biol Chem. 2001;276:40903-9 pubmed
    ..Specifically, the alpha4 cytoplasmic domain binds tightly to paxillin, a signaling adaptor protein, leading to increased cell migration and an altered cytoskeletal organization that ..
  7. Chen H, Shen C, Tsai Y, Lin F, Huang Y, Chen R. Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Mol Cell Biol. 2004;24:10558-72 pubmed
    ..In the present study, we not only identified paxillin as the binding partner and substrate of Brk but also discovered a novel signaling pathway by which Brk mediates ..
  8. Frank S, Adelstein M, Hansen S. GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. EMBO J. 2006;25:1848-59 pubmed
    ..GITs) regulate focal adhesion (FA) turnover, cell spreading, and motility through direct interaction with paxillin and the Rac-exchange factor Pak-interacting exchange factor beta (betaPIX)...
  9. Huang C, Borchers C, Schaller M, Jacobson K. Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells. J Cell Biol. 2004;164:593-602 pubmed
    Cell adhesions play an important role in neurite extension. Paxillin, a focal adhesion adaptor protein involved in focal adhesion dynamics, has been demonstrated to be required for neurite outgrowth...
  10. Sen A, De Castro I, DeFranco D, Deng F, Melamed J, Kapur P, et al. Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation. J Clin Invest. 2012;122:2469-81 pubmed publisher
    ..Here, we demonstrate that paxillin, a known cytoplasmic adaptor protein, regulates both androgen- and EGF-induced nuclear signaling...
  11. Turner C. Paxillin. Int J Biochem Cell Biol. 1998;30:955-9 pubmed
    b>Paxillin is a 68 kDa cytoplasmic protein that localizes to discrete sites of cell attachment to the extracellular matrix called focal adhesions...
  12. Zhao Z, Manser E, Loo T, Lim L. Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol Cell Biol. 2000;20:6354-63 pubmed
    ..Overexpression of GIT1 in fibroblasts or epithelial cells causes a loss of paxillin from FCs and stimulates cell motility...
  13. Cai H, Yang L, Song X, Liu Z, Chen Y, Dong G. Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma. Mol Med Rep. 2012;5:469-72 pubmed publisher
    The objective of the present study was to investigate the expression of paxillin and focal adhesion kinase (FAK) mRNA in esophageal carcinoma tissues, and their relationship with clinicopathological parameters, as ..
  14. Bellis S, Perrotta J, Curtis M, Turner C. Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin. Biochem J. 1997;325 ( Pt 2):375-81 pubmed
    Tyrosine phosphorylation of paxillin by the focal adhesion kinase (FAK) has been implicated as a signal transduction mechanism associated with cell adhesion and cytoskeletal reorganization...
  15. Salgia R, Uemura N, Okuda K, Li J, Pisick E, Sattler M, et al. CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. J Biol Chem. 1995;270:29145-50 pubmed
    ..other phosphoproteins were also detected in anti-CRKL immunoprecipitates, one of which has been identified as paxillin, a 68-kDa focal adhesion protein which we have previously shown to be phosphorylated by p210BCR/ABL...
  16. Metalli D, Lovat F, Tripodi F, Genua M, Xu S, Spinelli M, et al. The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. Am J Pathol. 2010;176:2997-3006 pubmed publisher
    ..protein kinase (MAPK) pathways as well as IGF-I-induced Akt- and MAPK-dependent phosphorylation of paxillin, which relocated at dynamic focal adhesions and was necessary for promoting motility in bladder cancer cells...
  17. Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K. Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. J Biol Chem. 1998;273:26516-21 pubmed
    ..Structurally, Hic-5 and paxillin, a 68-kDa cytoskeletal protein, share homology such as the LD motifs in the N-terminal half and the LIM domains ..
  18. Ballestrem C, Erez N, Kirchner J, Kam Z, Bershadsky A, Geiger B. Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci. 2006;119:866-75 pubmed
    ..Here we studied molecular interactions and tyrosine phosphorylation of paxillin, Crk-associated substrate (CAS), and focal adhesion kinase (FAK) in focal adhesions...
  19. Conway W, van der Voort van Zyp J, Thamilselvan V, Walsh M, Crowe D, Basson M. Paxillin modulates squamous cancer cell adhesion and is important in pressure-augmented adhesion. J Cell Biochem. 2006;98:1507-16 pubmed
    b>Paxillin is an adapter protein regulating signaling and focal adhesion assembly that has been linked to malignant potential in many malignancies. Overexpression of paxillin has been noted in aggressive tumors...
  20. Dai Y, Pierson S, Dudney W, Stack B. Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth. Int J Cancer. 2010;126:611-9 pubmed publisher
    ..Further gene array analysis, immunohistochemistry staining and Western blotting reveal that MPS-1 reduces paxillin mRNA and protein levels in UMSCC-1 cells both in vitro and in vivo...
  21. Nikolopoulos S, Turner C. Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. J Biol Chem. 2001;276:23499-505 pubmed
    b>Paxillin is a focal adhesion adapter protein involved in integrin signaling...
  22. Herreros L, Rodríguez Fernandez J, Brown M, Alonso Lebrero J, Cabanas C, Sanchez Madrid F, et al. Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. J Biol Chem. 2000;275:26436-40 pubmed
    b>Paxillin is a focal adhesion-associated protein that functions as a multi-domain adapter protein, binding several structural and signaling molecules...
  23. Ivankovic Dikic I, Gronroos E, Blaukat A, Barth B, Dikic I. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Nat Cell Biol. 2000;2:574-81 pubmed
    ..and autophosphorylation of Pyk2/FAK, as well as of effectors of their adhesion-targeting domains, such as paxillin, are important for propagation of signals that control neurite formation...
  24. Wang X, Fukuda K, Byeon I, Velyvis A, Wu C, Gronenborn A, et al. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. J Biol Chem. 2008;283:21113-9 pubmed publisher
    ..contains two calponin homology (CH) domains and its C-terminal CH2 domain binds multiple targets including paxillin LD motifs for regulating the FA network and signaling...
  25. Shi J, Wang S, Zhao E, Shi L, Xu X, Fang M. Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma. J Oral Pathol Med. 2010;39:548-51 pubmed publisher
    To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC). A total of 47 SACC were assessed histochemically for paxillin expression...
  26. Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, et al. Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin. PLoS Biol. 2009;7:e1000116 pubmed publisher
    ..Nudel bound to paxillin, a scaffold protein of focal contacts, and colocalized with it in areas of active membrane protrusions, ..
  27. Jun Q, Zhiwei W, Lilin M, Jing K, Qichao N. Effects of paxillin on HCT-8 human colorectal cancer cells. Hepatogastroenterology. 2011;58:1951-5 pubmed publisher
    The aim of this study was to investigate the effects of paxillin on proliferation, migration, invasion, adhesion and apoptosis of HCT-8 human colorectal cancer cells in vitro...
  28. Li H, Xie D, Shen X, Li H, Zeng H, Zeng Y. Clinicopathological significance of expression of paxillin, syndecan-1 and EMMPRIN in hepatocellular carcinoma. World J Gastroenterol. 2005;11:1445-51 pubmed
    To evaluate the relationship of expression of paxillin, syndecan-1 and EMMPRIN proteins with clinicopathological features in hepatocellular carcinoma (HCC). Fifty-one patients who underwent HCC resection were recruited in the study...
  29. Nishiya N, Shirai T, Suzuki W, Nose K. Hic-5 interacts with GIT1 with a different binding mode from paxillin. J Biochem. 2002;132:279-89 pubmed
    Hic-5, a member of the paxillin family of adaptor molecules, is localized at focal adhesion and implicated in integrin-mediated signaling...
  30. Taniyama Y, Weber D, Rocic P, Hilenski L, Akers M, Park J, et al. Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Mol Cell Biol. 2003;23:8019-29 pubmed
    ..of smooth muscle cells with a Tyr9 mutant of PDK1 inhibits angiotensin II-induced tyrosine phosphorylation of paxillin and focal adhesion formation...
  31. Tachibana K, Sato T, D Avirro N, Morimoto C. Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK. J Exp Med. 1995;182:1089-99 pubmed
    ..We demonstrate that pp125FAK is directly associated with paxillin, a 68-kD cytoskeleton protein...
  32. Retta S, Barry S, Critchley D, Defilippi P, Silengo L, Tarone G. Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity. Exp Cell Res. 1996;229:307-17 pubmed
    ..In the present study we examined the role of tyrosine phosphatases in this process using p125FAK and paxillin as substrates...
  33. Iwasaki T, Nakata A, Mukai M, Shinkai K, Yano H, Sabe H, et al. Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration. Int J Cancer. 2002;97:330-5 pubmed
    ..Consequently, tyrosine-phosphorylation of paxillin was obviously persistent after stimulation with FN + LPA as compared to after stimulation with either alone...
  34. Nikolopoulos S, Turner C. Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion. J Cell Biol. 2000;151:1435-48 pubmed
    b>Paxillin is a focal adhesion adapter protein involved in the integration of growth factor- and adhesion-mediated signal transduction pathways...
  35. Lewis J, Schwartz M. Integrins regulate the association and phosphorylation of paxillin by c-Abl. J Biol Chem. 1998;273:14225-30 pubmed
    ..transiently co-precipitate with c-Abl during cell adhesion, and one was identified as the focal adhesion protein paxillin. Abl also became transiently phosphorylated in response to cell adhesion...
  36. Turner C, Miller J. Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region. J Cell Sci. 1994;107 ( Pt 6):1583-91 pubmed
    b>Paxillin is a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix...
  37. Brown M, Perrotta J, Turner C. Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. J Cell Biol. 1996;135:1109-23 pubmed
    b>Paxillin is a 68-kD focal adhesion phosphoprotein that interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, and the cytoskeletal proteins vinculin and the tyrosine kinase,..
  38. Sen A, O Malley K, Wang Z, Raj G, DeFranco D, Hammes S. Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells. J Biol Chem. 2010;285:28787-95 pubmed publisher
    ..Previously, we have shown that paxillin, a multidomain adaptor protein, is a critical regulator of testosterone-induced MAPK-signaling during Xenopus ..
  39. Shen Y, Schneider G, Cloutier J, Veillette A, Schaller M. Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin. J Biol Chem. 1998;273:6474-81 pubmed
    ..adhesion kinase (FAK) functions in regulating tyrosine phosphorylation of several of these proteins, including paxillin, tensin, and p130(cas)...
  40. Liu S, Thomas S, Woodside D, Rose D, Kiosses W, Pfaff M, et al. Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature. 1999;402:676-81 pubmed
    ..report that the alpha4 tail, but not several other alpha-subunit tails, binds tightly to the signalling adaptor paxillin. Paxillin physically associated with alpha4 integrins in Jurkat T cells at high stoichiometry, and joining the ..
  41. Deakin N, Bass M, Warwood S, Schoelermann J, Mostafavi Pour Z, Knight D, et al. An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. J Cell Sci. 2009;122:1654-64 pubmed publisher
    ..activity of alpha4 integrin is mediated in part through the direct binding of the cytoplasmic domain to paxillin. Here, using intermolecular FRET and biochemical analyses, we report a novel interaction of the alpha4 integrin ..
  42. Birukova A, Cokic I, Moldobaeva N, Birukov K. Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF. Am J Respir Cell Mol Biol. 2009;40:99-107 pubmed publisher
    ..This study examined a role of FA protein paxillin in the pulmonary EC barrier responses induced by HGF and VEGF...
  43. Li B, Lei W, Zhang C, Zhou F, Li N, Shi S, et al. Increased expression of paxillin is found in human oesophageal squamous cell carcinoma: a tissue microarray study. J Int Med Res. 2008;36:273-8 pubmed
    ..Research has, therefore, concentrated on searching for specific biomarkers. Paxillin has been shown to play an important role in controlling cell spread and migration...
  44. Schaller M, Schaefer E. Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin. Biochem J. 2001;360:57-66 pubmed
    b>Paxillin is a focal-adhesion-associated, tyrosine-phosphorylated protein. In cells transformed by the src, crk or BCR-Abl oncogenes, the phosphotyrosine content of paxillin is elevated...
  45. Liu Z, Yu C, Nickel C, Thomas S, Cantley L. Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association. J Biol Chem. 2002;277:10452-8 pubmed
    ..epithelial cells, we studied the effect of HGF on the focal adhesion proteins, focal adhesion kinase (FAK) and paxillin and their association...
  46. Brown M, Turner C. Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Int J Biochem Cell Biol. 2002;34:855-63 pubmed
    ..b>Paxillin is a multi-domain FA adaptor protein containing five amino-terminal paxillin leucine-aspartate repeat (LD) motifs ..
  47. Nishiya N, Kiosses W, Han J, Ginsberg M. An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol. 2005;7:343-52 pubmed
    ..Restriction of alpha4 integrin phosphorylation to the leading edge limits the interaction of alpha4 with paxillin to the sides and rear of a migrating cell...
  48. Premont R, Claing A, Vitale N, Perry S, Lefkowitz R. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. J Biol Chem. 2000;275:22373-80 pubmed
    ..2 and with p21-activated kinase-interacting exchange factors complexed with p21-activated kinase but not with paxillin. Cellular overexpression of the longest variant of GIT2 leads to inhibition of beta(2)-adrenergic receptor ..
  49. Cote J, Turner C, Tremblay M. Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST. J Biol Chem. 1999;274:20550-60 pubmed
    ..Recently, paxillin was also demonstrated to interact with PTP-PEST (Shen, Y., Schneider, G., Cloutier, J. F., Veillette, A...
  50. Kanteti R, Yala S, Ferguson M, Salgia R. MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance. J Environ Pathol Toxicol Oncol. 2009;28:89-98 pubmed
    ..such as MET, hepatocyte growth factor [(HGF), ligand for MET), epidermal growth factor receptor (EGFR), and paxillin (PXN), is likely to determine both the type of treatment and prognosis...
  51. Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon A, Seiwert T, et al. Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. Cancer Res. 2008;68:132-42 pubmed publisher
    ..The focal adhesion protein paxillin is a target of a number of oncogenes involved in key signal transduction and important in cell motility and ..
  52. Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, et al. Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. J Biol Chem. 1998;273:1003-14 pubmed
    ..The amino acid sequence of Hic-5 is highly similar to that of paxillin in the four LD motifs as well as in the four contiguous LIM domains...
  53. Deakin N, Turner C. Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell. 2011;22:327-41 pubmed publisher
    ..Herein we show that the focal adhesion adaptor protein, paxillin , and the closely related Hic-5 have distinct and unique roles in the regulation of breast cancer cell lung ..
  54. Sorenson C. Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching. J Biol Chem. 2004;279:11368-74 pubmed
    ..and/or may play a more "active" role during morphogenesis by interacting with other proteins such as paxillin. Recent work in this laboratory demonstrated that bcl-2 directly associates with paxillin...