PAX8

Summary

Gene Symbol: PAX8
Description: paired box 8
Alias: paired box protein Pax-8, paired domain gene 8
Species: human
Products:     PAX8

Top Publications

  1. Tonacchera M, Banco M, Montanelli L, Di Cosmo C, Agretti P, De Marco G, et al. Genetic analysis of the PAX8 gene in children with congenital hypothyroidism and dysgenetic or eutopic thyroid glands: identification of a novel sequence variant. Clin Endocrinol (Oxf). 2007;67:34-40 pubmed
    To analyse the coding region of PAX8 in individuals with congenital (CH) or post neonatal hypothyroidism due to dysgenetic (TD) or eutopic thyroid glands...
  2. Eccles M, Yun K, Reeve A, Fidler A. Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am J Pathol. 1995;146:40-5 pubmed
    ..Two members of the paired box family of genes, PAX2 and PAX8, are expressed in WT and are potentially involved in its induction...
  3. Lanzerath K, Bettendorf M, Haag C, Kneppo C, Schulze E, Grulich Henn J. Screening for Pax8 mutations in patients with congenital hypothyroidism in South-West Germany. Horm Res. 2006;66:96-100 pubmed
    To study the frequency of mutations in the Pax8 gene in a cohort of patients with congenital hypothyroidism (CH) in South West Germany...
  4. Mansouri A, Chowdhury K, Gruss P. Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet. 1998;19:87-90 pubmed
    ..By analysis of Pax8-/- mice, we demonstrate that Pax8 is required for the formation of the follicular cells in the thyroid...
  5. Vilain C, Rydlewski C, Duprez L, Heinrichs C, Abramowicz M, Malvaux P, et al. Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8. J Clin Endocrinol Metab. 2001;86:234-8 pubmed
    ..b>PAX8 is a transcription factor involved in thyroid development...
  6. Grasberger H, Ringkananont U, Lefrancois P, Abramowicz M, Vassart G, Refetoff S. Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity. Mol Endocrinol. 2005;19:1779-91 pubmed
    Mutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis...
  7. Castro P, Rebocho A, Soares R, Magalhaes J, Roque L, Trovisco V, et al. PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma. J Clin Endocrinol Metab. 2006;91:213-20 pubmed
    ..find whether or not FVPTC cases share the molecular features of follicular tumors, we searched for the presence of PAX8-PPARgamma rearrangements, RAS mutations, and RAP-1, RAF-1, and BRAF mutations in a series of 40 FVPTCs as well as ..
  8. McKnight R, Cohen C, Siddiqui M. Utility of paired box gene 8 (PAX8) expression in fluid and fine-needle aspiration cytology: an immunohistochemical study of metastatic ovarian serous carcinoma. Cancer Cytopathol. 2010;118:298-302 pubmed publisher
    ..Recently, paired box gene 8 (PAX8) has been used in distinguishing ovarian from mammary carcinoma...
  9. Narumi S, Muroya K, Asakura Y, Adachi M, Hasegawa T. Transcription factor mutations and congenital hypothyroidism: systematic genetic screening of a population-based cohort of Japanese patients. J Clin Endocrinol Metab. 2010;95:1981-5 pubmed publisher
    ..This study was designed to define the prevalence of CH due to mutations of PAX8, NKX2-1 [encoding thyroid transcription factor (TTF)-1], FOXE1 (encoding TTF-2), and NKX2-5 among patients with ..

More Information

Publications82

  1. Mhawech Fauceglia P, Wang D, Samrao D, Godoy H, Ough F, Liu S, et al. Pair Box 8 (PAX8) protein expression in high grade, late stage (stages III and IV) ovarian serous carcinoma. Gynecol Oncol. 2012;127:198-201 pubmed publisher
    Pair-Box 8 (PAX8) is a transcription factor which has been found to be overexpressed in ovarian serous carcinoma (OSC)...
  2. Al Taji E, Biebermann H, Limanova Z, Hnikova O, Zikmund J, Dame C, et al. Screening for mutations in transcription factors in a Czech cohort of 170 patients with congenital and early-onset hypothyroidism: identification of a novel PAX8 mutation in dominantly inherited early-onset non-autoimmune hypothyroidism. Eur J Endocrinol. 2007;156:521-9 pubmed
    Mutations in NKX2.1, NKX2.5, FOXE1 and PAX8 genes, encoding for transcription factors involved in the development of the thyroid gland, have been identified in a minority of patients with syndromic and non-syndromic congenital ..
  3. Mhawech Fauceglia P, Wang D, Samrao D, Godoy H, Pejovic T, Liu S, et al. Pair-Box (PAX8) protein-positive expression is associated with poor disease outcome in women with endometrial cancer. Br J Cancer. 2012;107:370-4 pubmed publisher
    The Pax8 transcription factor genes have a role in cell differentiation and cell growth, and silencing of Pax8 in cell cultures results in cell death...
  4. Meeus L, Gilbert B, Rydlewski C, Parma J, Roussie A, Abramowicz M, et al. Characterization of a novel loss of function mutation of PAX8 in a familial case of congenital hypothyroidism with in-place, normal-sized thyroid. J Clin Endocrinol Metab. 2004;89:4285-91 pubmed
    ..b>PAX8 is one of these transcription factors, and so far, five mutations have been identified in its paired domain in ..
  5. Knoepp S, Kunju L, Roh M. Utility of PAX8 and PAX2 immunohistochemistry in the identification of renal cell carcinoma in diagnostic cytology. Diagn Cytopathol. 2012;40:667-72 pubmed publisher
    ..Recently, PAX2 was shown to be useful in this regard. In this study, we sought to compare the utility of PAX8 to that of PAX2 immunohistochemistry in the diagnosis of RCC in cytology specimens...
  6. Long K, Srivastava A, Hirsch M, Hornick J. PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors. Am J Surg Pathol. 2010;34:723-9 pubmed publisher
    ..We recently observed that islet cells show strong, diffuse staining for PAX8 by immunohistochemistry...
  7. De Leo R, Miccadei S, Zammarchi E, Civitareale D. Role for p300 in Pax 8 induction of thyroperoxidase gene expression. J Biol Chem. 2000;275:34100-5 pubmed
    ..In agreement with our finding and with the ability of the adenoviral protein E1A to bind p300, we show that E1A down-regulates Pax 8 activity. ..
  8. Tong G, Devaraj K, Hamele Bena D, Yu W, Turk A, Chen X, et al. Pax8: a marker for carcinoma of Müllerian origin in serous effusions. Diagn Cytopathol. 2011;39:567-74 pubmed publisher
    b>PAX8 is a nuclear transcription factor with limited expression in normal and neoplastic tissues in a cell lineage-dependent manner. PAX8 has been detected in embryonic Müllerian ducts, human fallopian tubes, and ovarian carcinomas...
  9. Di Palma T, Zampella E, Filippone M, Macchia P, Ris Stalpers C, De Vroede M, et al. Characterization of a novel loss-of-function mutation of PAX8 associated with congenital hypothyroidism. Clin Endocrinol (Oxf). 2010;73:808-14 pubmed publisher
    ..Recently, mutations in the PAX8 transcription factor have been identified in patients with TD...
  10. Congdon T, Nguyen L, Nogueira C, Habiby R, Medeiros Neto G, Kopp P. A novel mutation (Q40P) in PAX8 associated with congenital hypothyroidism and thyroid hypoplasia: evidence for phenotypic variability in mother and child. J Clin Endocrinol Metab. 2001;86:3962-7 pubmed
    ..including mutations in the TSHbeta-subunit, the TSH receptor, the G(s)alpha-subunit, and the transcription factor PAX8. Four girls with sporadic congenital hypothyroidism and hypoplastic thyroid glands were analyzed for mutations in ..
  11. Haynes C, Sangoi A, Pai R. PAX8 is expressed in pancreatic well-differentiated neuroendocrine tumors and in extrapancreatic poorly differentiated neuroendocrine carcinomas in fine-needle aspiration biopsy specimens. Cancer Cytopathol. 2011;119:193-201 pubmed publisher
    PAX (paired box) genes encode a family of transcription factors important for organogenesis. Recently, PAX8 has been recognized as a potential immunohistochemical marker of pancreatic neuroendocrine tumors...
  12. Poleev A, Fickenscher H, Mundlos S, Winterpacht A, Zabel B, Fidler A, et al. PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development. 1992;116:611-23 pubmed
    Recent evidence indicates a crucial role for paired box genes in mouse and human embryogenesis. The murine Pax8 gene encodes a sequence-specific transcription factor and is expressed in the developing secretory system as well as in the ..
  13. Tong G, Yu W, Beaubier N, Weeden E, Hamele Bena D, Mansukhani M, et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 2009;22:1218-27 pubmed publisher
    ..Together with PAX2, PAX8 is a nephric-lineage transcription factor and is required for the establishment of renal-lineage cells and the ..
  14. Di Palma T, d Andrea B, Liguori G, Liguoro A, De Cristofaro T, Del Prete D, et al. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp Cell Res. 2009;315:162-75 pubmed publisher
    b>Pax8 and TTF-1 are transcription factors involved in the morphogenesis of the thyroid gland and in the transcriptional regulation of thyroid-specific genes...
  15. Au A, McBride C, Wilhelm K, Koenig R, Speller B, Cheung L, et al. PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) disrupts normal PAX8 or PPARgamma transcriptional function and stimulates follicular thyroid cell growth. Endocrinology. 2006;147:367-76 pubmed
    ..associated with a chromosomal translocation that fuses the thyroid-specific transcription factor paired box gene 8 (PAX8) with the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma)...
  16. Bowen N, Logani S, Dickerson E, Kapa L, Akhtar M, Benigno B, et al. Emerging roles for PAX8 in ovarian cancer and endosalpingeal development. Gynecol Oncol. 2007;104:331-7 pubmed
    ..Aberrant transcriptional expression of PAX8 has been reported in epithelial ovarian cancer, prompting us to initiate the molecular characterization of this ..
  17. Brunner A, Riss P, Heinze G, Meltzow E, Brustmann H. Immunoexpression of PAX 8 in endometrial cancer: relation to high-grade carcinoma and p53. Int J Gynecol Pathol. 2011;30:569-75 pubmed publisher
    ..PAX 8 overexpression correlates with p53 expression and high-grade endometrial carcinomas but seems not to be useful as a prognostic parameter. ..
  18. Puppin C, Presta I, D Elia A, Tell G, Arturi F, Russo D, et al. Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter. Mol Cell Endocrinol. 2004;214:117-25 pubmed
    ..By means of RT-PCR assays we found a correlation between the Hex and Pax8 (a different tissue-specific transcription factor, expressed in TFC) mRNA levels in normal and neoplastic thyroid ..
  19. Kozmik Z, Kurzbauer R, Dörfler P, Busslinger M. Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol Cell Biol. 1993;13:6024-35 pubmed
    ..Hence, alternative splicing of Pax-8 gene transcripts not only generates six different Pax-8 variants but is also temporally and spatially regulated during early mouse development. ..
  20. Li C, Nyman J, Braithwaite A, Eccles M. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene. 2011;30:4824-34 pubmed publisher
    ..Several PAX proteins (tissue-specific developmental regulators), including PAX8, interact with the RB protein, and thus regulate the cell cycle directly or indirectly...
  21. Codutti L, van Ingen H, Vascotto C, Fogolari F, Corazza A, Tell G, et al. The solution structure of DNA-free Pax-8 paired box domain accounts for redox regulation of transcriptional activity in the pax protein family. J Biol Chem. 2008;283:33321-8 pubmed publisher
    ..Finally, sequence conservation suggests that our findings could be a general feature of the Pax family transcription factors. ..
  22. Montanelli L, Tonacchera M. Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. Mol Cell Endocrinol. 2010;322:64-71 pubmed publisher
    ..TD is usually sporadic but mutations in transcription factors (PAX8, TTF1, FOXE1 and NKX2-5) involved in thyroid development have been shown to cause a minority of cases transmitted ..
  23. Macchia P, Lapi P, Krude H, Pirro M, Missero C, Chiovato L, et al. PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Nat Genet. 1998;19:83-6 pubmed
    ..We report mutations in the coding region of PAX8 in two sporadic patients and one familial case of TD...
  24. Fraizer G, Shimamura R, Zhang X, Saunders G. PAX 8 regulates human WT1 transcription through a novel DNA binding site. J Biol Chem. 1997;272:30678-87 pubmed
    ..Thus, we identified a novel functional binding site for the transcription factor PAX 8, suggesting that part of its role in kidney development may be as a modulator of WT1 expression in the kidney. ..
  25. Ozcan A, Shen S, Hamilton C, Anjana K, Coffey D, Krishnan B, et al. PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011;24:751-64 pubmed publisher
    ..This tissue/cell-specific expression is maintained during both neoplastic transformation and metastasis. PAX 8 is a sensitive and specific marker for tumors of renal, Müllerian, or thyroid origin in both primary and metastatic sites. ..
  26. Laury A, Perets R, Piao H, Krane J, Barletta J, French C, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011;35:816-26 pubmed publisher
    b>PAX8 is a paired-box gene important in embryogenesis of the thyroid, Müllerian, and renal/upper urinary tracts, and expression of PAX8 has been previously described in carcinomas from each of these sites...
  27. Poleev A, Wendler F, Fickenscher H, Zannini M, Yaginuma K, Abbott C, et al. Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors. Eur J Biochem. 1995;228:899-911 pubmed
    ..The murine and human Pax8 genes are expressed in developing and adult thyroid as well as in the developing secretory system and at the lower ..
  28. Carvalho A, Hermanns P, Rodrigues A, Sousa I, Anselmo J, Bikker H, et al. A new PAX8 mutation causing congenital hypothyroidism in three generations of a family is associated with abnormalities in the urogenital tract. Thyroid. 2013;23:1074-8 pubmed publisher
    ..The objective of this study was to screen the PAX8 gene and the PAX2 gene in a family with six cases of CH spanning three generations and presenting urogenital ..
  29. Nonaka D, Chiriboga L, Soslow R. Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol. 2008;32:1566-71 pubmed publisher
    ..Metastatic breast carcinoma can mimic a primary ovarian carcinoma. Pax8 is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and Müllerian system, and it ..
  30. Ferretti E, Arturi F, Mattei T, Scipioni A, Tell G, Tosi E, et al. Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines. Endocrinology. 2005;146:4009-15 pubmed
    ..During development, the paired-box gene 8 (PAX8) is expressed in the thyroid, kidney, and several areas of the central nervous system...
  31. Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R, Zannini M. The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem. 2003;278:3395-402 pubmed
    Pax genes encode for transcription factors essential for tissue development in many species. Pax8, the only member of the family expressed in the thyroid tissue, is involved in the morphogenesis of the gland and in the transcriptional ..
  32. Chen Y, Campbell H, Wiles A, Eccles M, Reddel R, Braithwaite A, et al. PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Res. 2008;68:5724-32 pubmed publisher
    ..The mRNA level of PAX8 showed a positive correlation with telomerase activity in glioma biopsies (r(2) = 0.75, P < 0...
  33. Krzyzewska I, Ensink J, Nawijn L, Mul A, Koch S, Venema A, et al. Genetic variant in CACNA1C is associated with PTSD in traumatized police officers. Eur J Hum Genet. 2018;26:247-257 pubmed publisher
    ..a suggestive association of one relatively large DMR between patients and controls, which was located at the PAX8 gene and previously associated with other psychiatric disorders...
  34. Antic T, Taxy J, Alikhan M, Segal J. Melanotic Translocation Renal Cell Carcinoma With a Novel ARID1B-TFE3 Gene Fusion. Am J Surg Pathol. 2017;41:1576-1580 pubmed publisher
    ..Immunostains for PAX8, CD10, MiTF, and CAIX were negative; keratins Cam 5.2 and AE1/AE3 were focally positive...
  35. Naik M, Pai S. Epididymis-like Tubules in Adult Renal Hypodysplasia: Immunohistochemical Features Indicate a Mesonephric Origin. Int J Surg Pathol. 2017;25:206-215 pubmed publisher
    ..The epididymis-like tubules expressed CD10, CK7, PAX8, and AR in the luminal epithelium, while the basal cells were positive for p63, CK7, and focally for CD10...
  36. Bi Y, Deng Y, Li S, Zhou X, Chen Y, Ma D, et al. Immunophenotypic and prognostic analysis of PAX8 and TTF-1 expressions in neuroendocrine carcinomas of thymic origin: A comparative study with their pulmonary counterparts. J Surg Oncol. 2016;114:697-702 pubmed publisher
    To investigate the immunoreactivity of TTF-1 and PAX8 in neuroendocrine carcinoma of thymic (TNEC) and pulmonary origins (PNEC), and whether their immunophenotyping could be used to distinguish between NEC of the two sites, as well as ..
  37. Ramkumar N, Stuart D, Calquin M, Wang S, Niimura F, Matsusaka T, et al. Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension. Physiol Rep. 2016;4: pubmed publisher
    ..Mice were generated which were hemizygous for the Pax8-rtTA and LC-1 transgenes and homozygous for loxP-flanked AGT alleles to achieve nephron-wide AGT disruption after ..
  38. Patne S, Johri N, Katiyar R, Trivedi S, Dwivedi U. Renal-type clear cell carcinoma of the prostate: a diagnostic challenge. Diagn Pathol. 2015;10:193 pubmed publisher
    ..membrane antigen, CD10, vimentin, and AMACR while negative for 34βE12, CK7, prostate specific antigen, and PAX8. The final diagnosis was renal-type clear cell carcinoma of the prostate...
  39. Musholt T, Musholt P. Molecular genetic markers for thyroid FNAB. Established assays and future perspective. Nuklearmedizin. 2015;54:94-100 pubmed
    ..Predominantly mutations of BRAF, RET/PTC, RAS, and PAX8/PPARγ or expression of miRNAs are analyzed...
  40. Mitra A, Davis D, Tomar S, Roy L, Gurler H, Xie J, et al. In vivo tumor growth of high-grade serous ovarian cancer cell lines. Gynecol Oncol. 2015;138:372-7 pubmed publisher
    ..All tumors were sectioned and assessed using H&E staining and immunohistochemistry for p53, PAX8 and WT1 expression. Six lines (OVCAR3, OVCAR4, OVCAR5, OVCAR8, CAOV3, and OVSAHO) formed i...
  41. Presta I, Arturi F, Ferretti E, Mattei T, Scarpelli D, Tosi E, et al. Recovery of NIS expression in thyroid cancer cells by overexpression of Pax8 gene. BMC Cancer. 2005;5:80 pubmed
    ..In this study, the anaplastic thyroid carcinoma ARO cells were stably transfected with a Pax8 gene expression vector...
  42. Di Palma T, Lucci V, De Cristofaro T, Filippone M, Zannini M. A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells. BMC Cancer. 2014;14:292 pubmed publisher
    b>PAX8 is a member of the paired box (Pax) multigene family of transcription factors, which are involved in the developmental and tissue-specific control of the expression of several genes in both vertebrates and invertebrates...
  43. Li S, Morley M, Lu M, Zhou S, Stewart K, French C, et al. Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development. Dev Biol. 2016;416:338-46 pubmed publisher
    ..express high levels of transcriptional regulators not normally expressed in the developing lung, including Pax2, Pax8, Pax9 and the Hoxa9-13 cluster...
  44. Yu J, Mai W, Cui Y, Kong L. Key genes and pathways predicted in papillary thyroid carcinoma based on bioinformatics analysis. J Endocrinol Invest. 2016;39:1285-1293 pubmed
    ..The down-regulated DEGs, including paired box 8 (PAX8), peroxisome proliferator-activated receptor gamma (PPARG), and cadherin 1, type 1 were found enriched in hsa05216:..
  45. Gu Y, Cohn S, Christie A, McKenzie T, Wolff N, Do Q, et al. Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade. Cancer Discov. 2017;7:900-917 pubmed publisher
    ..In contrast, targeting with PAX8, a transcription factor frequently overexpressed in ccRCC, led to ccRCC of different grades...
  46. Tavares C, Melo M, Cameselle Teijeiro J, Soares P, Sobrinho Simões M. ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome. Eur J Endocrinol. 2016;174:R117-26 pubmed publisher
    ..carcinoma and the encapsulated form of follicular variant of papillary carcinoma, displaying RAS mutations and PAX8/PPARγ rearrangement...
  47. Kim S, Nam J, Kim G, Choi Y, Choi C, Park C. Mesonephric Adenocarcinoma of the Uterine Corpus: A Case Report and Diagnostic Pitfall. Int J Surg Pathol. 2016;24:153-8 pubmed publisher
    ..The tumor cells were immunopositive for cytokeratin, vimentin, CD10 with a luminal staining pattern, PAX2, and PAX8, and immunonegative for estrogen receptor and progesterone receptor, which was consistent with tumor of mesonephric ..
  48. Park J, Yi J, Park C, Lim Y, Lee K, Lee K, et al. Role of BRAF and RAS Mutations in Extrathyroidal Extension in Papillary Thyroid Cancer. Cancer Genomics Proteomics. 2016;13:171-81 pubmed
    ..BRAF and RAS mutations were shown to have distinct effects on genes associated with ETE. Specifically, PAX8 and its downstream target WNT4 were differentially expressed according to mutation status in addition to ETE, ..
  49. Kwon H, Kim W, Eszlinger M, Paschke R, Song D, Kim M, et al. Molecular Diagnosis Using Residual Liquid-Based Cytology Materials for Patients with Nondiagnostic or Indeterminate Thyroid Nodules. Endocrinol Metab (Seoul). 2016;31:586-591 pubmed publisher
    ..DNAs and RNAs were isolated from residual LBC materials. BRAF(V600E) and RAS point mutations, PAX8/peroxisome proliferator-activated receptor ? (PPAR?), RET/PTC1, and RET/PTC3 rearrangements were evaluated by real-..
  50. Boscardin E, Perrier R, Sergi C, Maillard M, Loffing J, Loffing Cueni D, et al. Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice. Pflugers Arch. 2017;469:1387-1399 pubmed publisher
    ..or can be compensated by remaining (α and γ) ENaC subunits using adult nephron-specific knockout (Scnn1bPax8/LC1) mice...
  51. Lawrenson K, Pakzamir E, Liu B, Lee J, Delgado M, Duncan K, et al. Molecular Analysis of Mixed Endometrioid and Serous Adenocarcinoma of the Endometrium. PLoS ONE. 2015;10:e0130909 pubmed publisher
    ..even though MT-ECs closely resembled the molecular profiles of pure USCs, they also exhibit lower expression of PAX8 compared to all pure cases combined (P = 0.035)...
  52. Park S, Cho M. Vaginal Brenner tumor with literature review: does this tumour originate from Walthard nests?. Malays J Pathol. 2017;39:89-93 pubmed
    ..The epithelial tumor cells were positive for GATA-3, p63 and ER, but negative for PAX8. The origin of Brenner tumors in the vagina is unclear, but previous reports suggested of Müllerian origin...
  53. Ye J, Hameed O, Findeis Hosey J, Fan L, Li F, McMahon L, et al. Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung. Biotech Histochem. 2012;87:30-4 pubmed publisher
    ..We attempted to determine whether a tissue-specific transcriptional factor, PAX8, can help determine primary sites of lung carcinomas...
  54. Lee S, Sahasrabuddhe V, Mendoza Cervantes D, Zhao R, Duggan M. Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: A Systematic Review. Int J Gynecol Pathol. 2018;37:128-140 pubmed publisher
    ..AIS case-comparator biomarkers were HIK1083, alpha SMA, PAX8, VIL1, CEA, p53, p16, and CD10, and only alpha SMA had a difference of 100%...
  55. Liang Y, Zuo T. Papillary Thyroid Carcinoma Cervical Lymph Node Metastasis with Cystic Change Differentiated from Congenital Cystic Lesions with the Assistance of Immunohistochemistry: A Case Study. Head Neck Pathol. 2017;11:301-305 pubmed publisher
    ..Given that Pax8 and TTF-1 are common markers in thyroid follicular epithelium; we applied immunohistochemical stains of those two ..
  56. Celestino R, Sigstad E, Løvf M, Thomassen G, Grøholt K, Jørgensen L, et al. Survey of 548 oncogenic fusion transcripts in thyroid tumors supports the importance of the already established thyroid fusions genes. Genes Chromosomes Cancer. 2012;51:1154-64 pubmed publisher
    ..In the thyroid, the PAX8-PPARG fusion is present in the neoplastic lesions that have a follicular architecture-follicular thyroid carcinoma (..
  57. Batista F, Ward L, Marcello M, Martins M, Peres K, Torricelli C, et al. Gene expression of thyroid-specific transcription factors may help diagnose thyroid lesions but are not determinants of tumor progression. J Endocrinol Invest. 2016;39:423-9 pubmed publisher
    ..We quantified TTF-1, FOXE1 and PAX8 mRNA levels, relating their expression to diagnostic and prognostic features of thyroid tumors...
  58. Hermanns P, Grasberger H, Cohen R, Freiberg C, Dörr H, Refetoff S, et al. Two cases of thyroid dysgenesis caused by different novel PAX8 mutations in the DNA-binding region: in vitro studies reveal different pathogenic mechanisms. Thyroid. 2013;23:791-6 pubmed publisher
    Mutations in PAX8, a transcription factor gene, cause thyroid dysgenesis (TD). The extreme variability of the thyroid phenotype makes it difficult to identify individuals harboring PAX8 gene mutations...
  59. Barr M, Jilaveanu L, Camp R, Adeniran A, Kluger H, Shuch B. PAX-8 expression in renal tumours and distant sites: a useful marker of primary and metastatic renal cell carcinoma?. J Clin Pathol. 2015;68:12-7 pubmed publisher
    ..Compared with normal tissue and other histological types, clear cell RCC has lower PAX-8 expression and is less frequently positive, therefore, the lack of expression does not exclude a tumour of renal origin. ..
  60. Mendoza A, Astapova I, Shimizu H, Gallop M, Al Sowaimel L, MacGowan S, et al. NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proc Natl Acad Sci U S A. 2017;114:E8458-E8467 pubmed publisher
    ..We tested this by expressing a hypomorphic NCoR1 allele (NCoR1?ID), which cannot interact with the TR, in Pax8-KO mice, which make no thyroid hormone...
  61. Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol. 2008;21:192-200 pubmed
    Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation. Compared with TTF-1, the other two markers have scarcely been investigated in surgical pathology...
  62. Marques A, Espadinha C, Catarino A, Moniz S, Pereira T, Sobrinho L, et al. Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab. 2002;87:3947-52 pubmed
    Recently, a translocation t(2;3)(q13;p25), leading to the formation of a chimeric PAX8-peroxisome proliferator-activated receptor (PPAR)gamma 1 oncogene, was detected in follicular thyroid carcinomas (FTC), but not in follicular thyroid ..
  63. Cheung L, Messina M, Gill A, Clarkson A, Learoyd D, Delbridge L, et al. Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab. 2003;88:354-7 pubmed
    ..reported a novel chromosomal translocation, t(2;3)(q13;p25), that fused the thyroid-specific transcription factor PAX8 with a nuclear receptor, peroxisome proliferator-activated receptor gamma (PPAR gamma)...
  64. Yemelyanova A, Gown A, Wu L, Holmes B, Ronnett B, Vang R. PAX8 expression in uterine adenocarcinomas and mesonephric proliferations. Int J Gynecol Pathol. 2014;33:492-9 pubmed publisher
    b>PAX8 is a useful immunohistochemical marker for the diagnosis of gynecologic tract malignancies. Several studies have described PAX8 expression in a wide variety of epithelial neoplasms, including ovarian and endometrial carcinomas...
  65. Bellevicine C, Iaccarino A, Malapelle U, Sasso F, Biondi B, Troncone G. PAX8 is expressed in anaplastic thyroid carcinoma diagnosed by fine-needle aspiration: a study of three cases with histological correlates. Eur J Endocrinol. 2013;169:307-11 pubmed publisher
    ..Recent studies have shown that immunostaining for paired box gene 8 (PAX8), a transcription factor expressed in normal thyroid, is effective for diagnosing ATCs on histology...
  66. Pina Oviedo S, Shen S, Truong L, Ayala A, Ro J. Flat pattern of nephrogenic adenoma: previously unrecognized pattern unveiled using PAX2 and PAX8 immunohistochemistry. Mod Pathol. 2013;26:792-8 pubmed publisher
    ..Recent studies have shown that nephrogenic adenomas are positive for PAX2 and PAX8. We encountered an interesting case of tubular nephrogenic adenoma with adjacent areas suspicious of flat ..
  67. Zhang Y, Yu J, Grachtchouk V, Qin T, Lumeng C, Sartor M, et al. Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer. Oncotarget. 2017;8:5761-5773 pubmed publisher
    b>PAX8-PPARG fusion protein (PPFP) results from a t(2;3)(q13;p25) chromosomal translocation, is found in 30% of follicular thyroid carcinomas, and demonstrates oncogenic capacity in transgenic mice...
  68. Koperski Ł, Pihowicz P, Szczepankiewicz B, Fus Ł, Cyran A, Bogdańska M, et al. Clinicopathological and immunohistochemical analysis of epithelial-lined (true) cysts of the adrenal gland with proposal of a new histogenetic categorization. Pathol Res Pract. 2017;213:1089-1096 pubmed publisher
    ..calretinin, WT1), and a negative reaction for EpCAM, EMA, PAX8 and ER...
  69. Fan R. PAX immunoreactivity in poorly differentiated small round cell tumors of childhood. Fetal Pediatr Pathol. 2014;33:244-52 pubmed publisher
    ..We report the immunoreactivity expression patterns of three PAX genes (PAX2, PAX5 and PAX8) in poorly differentiated small round cell tumors of childhood for possible useful diagnostic applications...
  70. Dupain C, Ali H, Mouhoub T, Urbinati G, Massaad Massade L. Induction of TTF-1 or PAX-8 expression on proliferation and tumorigenicity in thyroid carcinomas. Int J Oncol. 2016;49:1248-58 pubmed publisher
    ..It will also be important to study the two thyroid transcription factors as part of a duo. This could open in the long-term, new therapeutic perspectives for thyroid carcinomas. ..
  71. Nikolaeva S, Ansermet C, Centeno G, Pradervand S, Bize V, Mordasini D, et al. Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition. J Am Soc Nephrol. 2016;27:2997-3004 pubmed
    ..BMAL1, which is critically involved in the circadian clock system, in renal tubular cells (Bmal1lox/lox/Pax8-rtTA/LC1 mice)...
  72. Morgan E, Pozdnyakova O, Nascimento A, Hirsch M. PAX8 and PAX5 are differentially expressed in B-cell and T-cell lymphomas. Histopathology. 2013;62:406-13 pubmed publisher
    ..purpose of this study was to evaluate the expression patterns of B-cell specific activator protein (BSAP)/PAX5 and PAX8 in a wide variety of B-cell and T-cell neoplasms...
  73. Ordonez N. Value of PAX8, PAX2, claudin-4, and h-caldesmon immunostaining in distinguishing peritoneal epithelioid mesotheliomas from serous carcinomas. Mod Pathol. 2013;26:553-62 pubmed publisher
    ..Recent investigations have indicated that PAX8, PAX2, claudin-4, and h-caldesmon are immunohistochemical markers that can assist in distinguishing between these ..