PAX7

Summary

Gene Symbol: PAX7
Description: paired box 7
Alias: HUP1, PAX7B, RMS2, paired box protein Pax-7, PAX7 transcriptional factor, paired box homeotic gene 7, paired domain gene 7
Species: human
Products:     PAX7

Top Publications

  1. Barr F, Nauta L, Davis R, Schafer B, Nycum L, Biegel J. In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma. Hum Mol Genet. 1996;5:15-21 pubmed
    ..characteristic t(2;13)(q35;q14) or variant t(1;13)(p36;q14) chromosomal translocations generate PAX3-FKHR or PAX7-FKHR fusion genes...
  2. Williamson D, Missiaglia E, de Reynies A, Pierron G, Thuille B, Palenzuela G, et al. Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma. J Clin Oncol. 2010;28:2151-8 pubmed publisher
  3. Cleveland B, Manor M. Effects of phytoestrogens on growth-related and lipogenic genes in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol. 2015;170:28-37 pubmed publisher
    ..Expression of muscle regulatory factors pax7 and myod was increased by E2 and genistein...
  4. Davegårdh C, Broholm C, Perfilyev A, Henriksen T, García Calzón S, Peijs L, et al. Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects. BMC Med. 2017;15:39 pubmed publisher
    ..We identified epigenetic and transcriptional changes of myogenic transcription factors (MYOD1, MYOG, MYF5, MYF6, PAX7, MEF2A, MEF2C, and MEF2D), cell cycle regulators, metabolic enzymes and genes previously not linked to myogenesis, ..
  5. Su Z, Hu L, Cheng J, Klein J, Hassounah F, Cai H, et al. Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy. J Appl Physiol (1985). 2016;120:426-36 pubmed publisher
    ..The abundances of Pax7, MyoD, myogenin, and embryonic myosin heavy chain were significantly increased by Acu-LFES in both normal and ..
  6. Monsoro Burq A. PAX transcription factors in neural crest development. Semin Cell Dev Biol. 2015;44:87-96 pubmed publisher
    ..Recent studies have highlighted the role of PAX3 and PAX7 in neural crest induction...
  7. Oliván S, Calvo A, Rando A, Herrando Grabulosa M, Manzano R, Zaragoza P, et al. Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy. Front Mol Neurosci. 2016;9:76 pubmed publisher
    ..Regarding the genes related to muscular atrophy (Ankrd1, Calm1, Col19a1, Fbox32, Mt2, Myod1, NogoA, Pax7, Rrad, and Sln), TTC suggest a compensatory effect for muscle damage response, diminished oxidative stress and ..
  8. Miretti S, Volpe M, Martignani E, Accornero P, Baratta M. Temporal correlation between differentiation factor expression and microRNAs in Holstein bovine skeletal muscle. Animal. 2017;11:227-235 pubmed publisher
    ..At the time of isolation from muscle, PAX7 was expressed in nearly 100% of BoSCs; however, its messenger RNA (mRNA) levels dramatically decreased between 3 ..
  9. Braga M, Simmons Z, Norris K, Ferrini M, Artaza J. Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells. Endocr Connect. 2017;6:139-150 pubmed publisher
    ..male mice and then treated with 1,25-D3 The efficiency of satellite cells isolation determined by PAX7+ cells was 81%, and they expressed VDR...

More Information

Publications141 found, 100 shown here

  1. Xu P, Werner J, Milerski S, Hamp C, Kuzenko T, Jähnert M, et al. Diet-Induced Obesity Affects Muscle Regeneration After Murine Blunt Muscle Trauma-A Broad Spectrum Analysis. Front Physiol. 2018;9:674 pubmed publisher
    ..In summary, increased fibrosis formation, the reduction of Pax7+ satellite cells as well as specific changes in gene expression and signaling pathways could explain ..
  2. Oster M, Trakooljul N, Reyer H, Zeyner A, Murani E, Ponsuksili S, et al. Sex-Specific Muscular Maturation Responses Following Prenatal Exposure to Methylation-Related Micronutrients in Pigs. Nutrients. 2017;9: pubmed publisher
    ..decreased live weight postnatally, with compensatory transcriptional responses comprising myogenic key drivers (Pax7, MyoD1, myogenin)...
  3. FAYZULLINA S, Martin L. DNA Damage Response and DNA Repair in Skeletal Myocytes From a Mouse Model of Spinal Muscular Atrophy. J Neuropathol Exp Neurol. 2016;75:889-902 pubmed publisher
    ..cells of neonatal control and mutant SMN mice had similar myotube length, myonuclei, satellite cell marker Pax7 and differentiated myotube marker myosin, and acetylcholine receptor clustering...
  4. Morales M, Acuña M, Cabrera D, Goldschmeding R, Brandan E. The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle. J Cell Commun Signal. 2018;12:413-421 pubmed publisher
    ..Fibrotic and inflammatory markers were also decreased in these foci. We did not observe any difference in Pax7 mRNA levels, a marker for satellite cells, in mdx mice compared to mdx-Ccn2+/- mice...
  5. Frese S, Ruebner M, Suhr F, Konou T, Tappe K, Toigo M, et al. Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo. PLoS ONE. 2015;10:e0132099 pubmed publisher
    ..Syncytin-1, Syncytin-3, SLC1A4 and PAX7 gene regulations along with MyoD1 and myogenin were verified during proliferating or actively-fusing human primary ..
  6. Chacon Cabrera A, Gea J, Barreiro E. Short- and Long-Term Hindlimb Immobilization and Reloading: Profile of Epigenetic Events in Gastrocnemius. J Cell Physiol. 2017;232:1415-1427 pubmed publisher
    ..miR-486, SIRT1 levels, and slow- and fast-twitch cross-sectional areas were decreased in mice of I groups, whereas Pax7 and acetylated FoxO1 and FoxO3 levels were increased...
  7. Yablonka Reuveni Z, Danoviz M, Phelps M, Stuelsatz P. Myogenic-specific ablation of Fgfr1 impairs FGF2-mediated proliferation of satellite cells at the myofiber niche but does not abolish the capacity for muscle regeneration. Front Aging Neurosci. 2015;7:85 pubmed publisher
    Skeletal muscle satellite cells (SCs) are Pax7(+) myogenic stem cells that reside between the basal lamina and the plasmalemma of the myofiber...
  8. Lamarche Ã, Lala Tabbert N, Gunanayagam A, St Louis C, Wiper Bergeron N. Retinoic acid promotes myogenesis in myoblasts by antagonizing transforming growth factor-beta signaling via C/EBPβ. Skelet Muscle. 2015;5:8 pubmed publisher
    ..RA treatment reduces C/EBPβ occupancy of the Pax7 and Smad2 promoters and decreased their expression...
  9. Palade J, Djordjevic D, Hutchins E, George R, Cornelius J, Rawls A, et al. Identification of satellite cells from anole lizard skeletal muscle and demonstration of expanded musculoskeletal potential. Dev Biol. 2018;433:344-356 pubmed publisher
    ..We previously isolated PAX7-positive cells from muscle of the green anole lizard, Anolis carolinensis, that can differentiate into ..
  10. Pinheiro D, da Silva R, Barbosa T, Gama J, Gomes A, Quirico Santos T, et al. Omentum acts as a regulatory organ controlling skeletal muscle repair of mdx mice diaphragm. Cell Tissue Res. 2019;: pubmed publisher
    ..Although omentectomized mice had high levels of Pax7, myogenin and TNF-α, the percentage of myofibers undergoing regeneration was low thus suggesting that a lack of ..
  11. Athar F, Parnaik V. Potential gene regulatory role for cyclin D3 in muscle cells. J Biosci. 2015;40:497-512 pubmed
    ..D3 in undifferentiated myoblasts altered histone epigenetic marks at promoters of muscle-specific genes like MyoD, Pax7, myogenin and muscle creatine kinase but not non-muscle genes...
  12. Padilla Benavides T, Nasipak B, Paskavitz A, Haokip D, Schnabl J, Nickerson J, et al. Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition. J Biol Chem. 2017;292:18592-18607 pubmed publisher
    ..Moreover, pharmacological inhibition of CK2 increased myoblast proliferation. Furthermore, the Pax7 promoter, which controls expression of a key transcription factor required for myoblast proliferation, was in ..
  13. Thway K, Wang J, Wren D, Dainton M, Gonzalez D, Swansbury J, et al. The comparative utility of fluorescence in situ hybridization and reverse transcription-polymerase chain reaction in the diagnosis of alveolar rhabdomyosarcoma. Virchows Arch. 2015;467:217-24 pubmed publisher
    ..All solid variant ARMS harbored FOXO1 gene rearrangements and PAX3-FOXO1 ARMS were detected to the exclusion of PAX7-FOXO1...
  14. Swiderski K, Thakur S, Naim T, Trieu J, Chee A, Stapleton D, et al. Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury. Skelet Muscle. 2016;6:36 pubmed
    ..Gene expression analysis of the regeneration markers Pax7, MyoD, and Myogenin indicated SOCS3 deletion had no effect on the progression of muscle repair ..
  15. Koya T, Nishizawa S, Ohno Y, Goto A, Ikuta A, Suzuki M, et al. Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle. PLoS ONE. 2013;8:e77788 pubmed publisher
    ..Population of Pax7-positive muscle satellite cells in HSF1-null mice was significantly less than that in wild-type mice following 2 ..
  16. Kozakowska M, Kotlinowski J, Grochot Przeczek A, Ciesla M, Pilecki B, Derlacz R, et al. Myoblast-conditioned media improve regeneration and revascularization of ischemic muscles in diabetic mice. Stem Cell Res Ther. 2015;6:61 pubmed publisher
    ..to their wild-type counterparts, what was accompanied by increased levels of Myf5 or CXCR4, and decreased Mef2 or Pax7. Such cells also displayed diminished differentiation potential when cultured in vitro, as shown by less effective ..
  17. Thuault S, Comunale F, Hasna J, Fortier M, Planchon D, Elarouci N, et al. The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity. Mol Biol Cell. 2016;27:2653-61 pubmed publisher
    ..Among RMS subtypes, alveolar rhabdomyosarcoma (ARMS), which is characterized by the presence of the PAX3-FOXO1A or PAX7-FOXO1A chimeric oncogenic transcription factor, is associated with poor prognosis and a strong risk of metastasis ..
  18. Beccafico S, Morozzi G, Marchetti M, Riccardi C, Sidoni A, Donato R, et al. Artesunate induces ROS- and p38 MAPK-mediated apoptosis and counteracts tumor growth in vivo in embryonal rhabdomyosarcoma cells. Carcinogenesis. 2015;36:1071-83 pubmed publisher
    ..to exit the cell cycle and terminally differentiate mainly because of overexpression of the transcription factor, PAX7, which sustains proliferation, migration and invasiveness in ERMS cells...
  19. Eftekhari K, Chambers C, Goldstein S, Katowitz W, Katowitz J. Alveolar rhabdomyosarcoma masquerading as embryonal subtype: the value of modern molecular diagnostic testing. Ophthalmic Plast Reconstr Surg. 2015;31:e43-5 pubmed publisher
    ..However, subsequent molecular genetic testing of the biopsy specimen was positive for the PAX3/PAX7-FKHR chimeric gene, indicating the tumor was actually an alveolar rhabdomyosarcoma...
  20. Laine J, Skoglund G, Fournier E, Tabti N. Development of the excitation-contraction coupling machinery and its relation to myofibrillogenesis in human iPSC-derived skeletal myocytes. Skelet Muscle. 2018;8:1 pubmed publisher
    ..b>Pax7+-myogenic progenitors were differentiated in culture, and developmental changes were examined from a few ..
  21. Neves J, Rizzato V, Fappi A, Garcia M, Chadi G, van de Vlekkert D, et al. Neuraminidase-1 mediates skeletal muscle regeneration. Biochim Biophys Acta. 2015;1852:1755-64 pubmed publisher
    ..This was accompanied by significant and sequential upregulation of Pax7, MyoD, and myogenin mRNAs...
  22. Eguía Aguilar P, López Martínez B, Retana Contreras C, Perezpeña Diazconti M. Alveolar rhabdomyosarcoma: origin and prognostic implications of molecular findings. Bol Med Hosp Infant Mex. 2016;73:405-410 pubmed publisher
    ..has been associated with the expression of oncogenic fusion proteins resulting from chromosomal translocations, particularly t(2;13) (q35;q14) PAX3/FOXO1, and t(1;13) (p36;q14) PAX7/FOXO1 which were present in this patient.
  23. Wei D, Ma X, Zhang S, Hong J, Gui L, Mei C, et al. Characterization of the promoter region of the bovine SIX1 gene: Roles of MyoD, PAX7, CREB and MyoG. Sci Rep. 2017;7:12599 pubmed publisher
    ..constructs of the 5' flanking region, site-directed mutation and siRNA interference demonstrated that MyoD, PAX7 and CREB binding occur in region -689/-40 and play important roles in bovine SIX1 transcription...
  24. Kinoshita H, Miyakoshi N, Kasukawa Y, Sakai S, Shiraishi A, Segawa T, et al. Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid-treated rats. J Bone Miner Metab. 2016;34:171-8 pubmed publisher
    ..b>Pax7, MyoD, and myogenin mRNA levels in gastrocnemius muscles were also determined...
  25. Singhal N, Martin P. A role for Galgt1 in skeletal muscle regeneration. Skelet Muscle. 2015;5:3 pubmed publisher
    ..Cardiotoxin-injected Galgt1 (-/-) muscles showed reduced gene expression of the satellite cell marker Pax7 and increased expression of myoblast markers MyoD, Myf5, and Myogenin after injury along with a tenfold increase in ..
  26. Radugina E, Almeida E, Blaber E, Poplinskaya V, Markitantova Y, Grigoryan E. Exposure to microgravity for 30 days onboard Bion M1 caused muscle atrophy and impaired regeneration in murine femoral Quadriceps. Life Sci Space Res (Amst). 2018;16:18-25 pubmed publisher
    ..activity of satellite cells in muscles was observed both in microgravity and ground control groups, using Pax7 and Myogenin immunolocalization, as well as Myogenin expression analysis...
  27. Boutet S, Disatnik M, Chan L, Iori K, Rando T. Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors. Cell. 2007;130:349-62 pubmed
    Pax3 and Pax7 play distinct but overlapping roles in developmental and postnatal myogenesis. The mechanisms involved in the differential regulation of these highly homologous proteins are unknown...
  28. Nogueira J, Hawrot K, Sharpe C, Noble A, Wood W, Jorge E, et al. The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development. Front Aging Neurosci. 2015;7:62 pubmed publisher
    b>Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury...
  29. Saera Vila A, Kasprick D, Junttila T, Grzegorski S, Louie K, Chiari E, et al. Myocyte Dedifferentiation Drives Extraocular Muscle Regeneration in Adult Zebrafish. Invest Ophthalmol Vis Sci. 2015;56:4977-93 pubmed publisher
    ..However, both immunofluorescence and electron microscopy failed to identify classic Pax7-positive satellite cells in control or injured EOMs...
  30. Filipova D, Walter A, Gaspar J, Brunn A, Linde N, Ardestani M, et al. Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca(2+) release channel. Sci Rep. 2016;6:20050 pubmed publisher
    ..Additional qRT-PCR analysis revealed altered mRNA levels of the canonical muscle regulatory factors Six1, Six4, Pax7, MyoD, MyoG and MRF4 in mutant muscle, which is in line with the severe developmental retardation seen in dyspedic ..
  31. Hwang O, Park J, Lee E, Lee E, Kim A, Jeong K. Therapeutic Effect of Losartan, an Angiotensin II Type 1 Receptor Antagonist, on CClâ‚„-Induced Skeletal Muscle Injury. Int J Mol Sci. 2016;17:227 pubmed publisher
    ..01). The expressions of Pax7, MyoD, and myogenin increased in skeletal muscles of the CClâ‚„ + losartan group compared to the corresponding ..
  32. Unno R, Mizuno K, Ito Y, Etani T, Okada A, Kawai N, et al. Treatment Strategy for Pediatric Paratesticular Rhabdomyosarcoma Based on Chimeric Gene Assessment. Urology. 2016;95:187-9 pubmed publisher
    ..One case was embryonal, whereas the other case was alveolar; the latter exhibited PAX7-FOXO1 gene chimerism and rapid progression...
  33. Hoedt A, Christensen B, Nellemann B, Mikkelsen U, Hansen M, Schjerling P, et al. Satellite cell response to erythropoietin treatment and endurance training in healthy young men. J Physiol. 2016;594:727-43 pubmed publisher
    ..Immunohistochemical analyses were used to quantify fibre type specific SCs (Pax7(+)), myonuclei and active SCs (Pax7(+)/MyoD(+))...
  34. Xiao L, Lee K. BRE facilitates skeletal muscle regeneration by promoting satellite cell motility and differentiation. Biol Open. 2016;5:100-11 pubmed publisher
    ..There were significantly fewer pax7(+) satellite cells and smaller newly formed myofibers present in the injury sites of BRE-KO mice...
  35. Wu G, Zhang J, Wang L, Xu S, Zhou J, Xiang A, et al. Sex- and age-dependent expression of Pax7, Myf 5, MyoG, and Myostatin in yak skeletal muscles. Genet Mol Res. 2016;15: pubmed publisher
    The aim of this study was to investigate the myogenic factor mRNA expression pattern of Pax7, Myf5, MyoG, and Myostatin mRNA at different ages, sexes, and muscle tissues of Datong yaks...
  36. Berberoglu M, Gallagher T, Morrow Z, Talbot J, Hromowyk K, Tenente I, et al. Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Dev Biol. 2017;424:162-180 pubmed publisher
    ..Finally, by analyzing pax7a; pax7b double mutant zebrafish, we show that Pax7 is required for adult skeletal muscle repair, as it is in the mouse.
  37. Fei J, Schuez M, Knapp D, Taniguchi Y, Drechsel D, Tanaka E. Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration. Proc Natl Acad Sci U S A. 2017;114:12501-12506 pubmed publisher
    ..5-kb) cassette into axolotl Sox2 and Pax7 genomic loci...
  38. Schaaf G, van Gestel T, Brusse E, Verdijk R, De Coo I, van Doorn P, et al. Lack of robust satellite cell activation and muscle regeneration during the progression of Pompe disease. Acta Neuropathol Commun. 2015;3:65 pubmed publisher
    ..The total number of Pax7-positive satellite cells in muscle biopsies from infantile, childhood onset and adult patients (with different ages ..
  39. Raz Y, Henseler J, Kolk A, Riaz M, van der Zwaal P, Nagels J, et al. Patterns of Age-Associated Degeneration Differ in Shoulder Muscles. Front Aging Neurosci. 2015;7:236 pubmed publisher
    ..an increase in extracellular collagen-1, a loss of myosin heavy chain-1 expression in myofibers and an increase in Pax7-positive cells. However, the adjacent intact teres minor and deltoid exhibited healthy muscle features...
  40. Pantic B, Borgia D, Giunco S, Malena A, Kiyono T, Salvatori S, et al. Reliable and versatile immortal muscle cell models from healthy and myotonic dystrophy type 1 primary human myoblasts. Exp Cell Res. 2016;342:39-51 pubmed publisher
    ..hSkMCs displayed attractive additional features such as structural maturation of sarcomeres, persistence of Pax7-positive cells during differentiation and complete disappearance of nuclear foci following (CAG)7 antisense ..
  41. Lilja K, Zhang N, Magli A, Gunduz V, Bowman C, Arpke R, et al. Pax7 remodels the chromatin landscape in skeletal muscle stem cells. PLoS ONE. 2017;12:e0176190 pubmed publisher
    ..to convert PSC to skeletal muscle cells, and the mechanisms by which the master regulatory transcription factor, Pax7, promotes muscle stem (satellite) cell identity are not yet understood...
  42. Haynes P, Kernan K, Zhou S, Miller D. Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures. Skelet Muscle. 2017;7:13 pubmed publisher
    ..binding domains similar to several paired class homeotic transcription factors, but only myogenic factors PAX3 and PAX7 rescue cell viability when co-expressed with DUX4 in mouse myoblasts...
  43. Hanna J, Garcia M, Lardennois A, Leavey P, Maglic D, Fagnan A, et al. PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. Oncogene. 2018;37:1991-2007 pubmed publisher
    ..The majority of ARMS tumors (80%) harbor a PAX3-FOXO1 or less commonly a PAX7-FOXO1 fusion gene...
  44. Czerwinska A, Grabowska I, Archacka K, Bem J, Świerczek B, Helinska A, et al. Myogenic Differentiation of Mouse Embryonic Stem Cells That Lack a Functional Pax7 Gene. Stem Cells Dev. 2016;25:285-300 pubmed publisher
    The transcription factor Pax7 plays a key role during embryonic myogenesis and sustains the proper function of satellite cells, which serve as adult skeletal muscle stem cells...
  45. Mancinelli R, Di Filippo E, Verratti V, Fulle S, Toniolo L, Reggiani C, et al. The Regenerative Potential of Female Skeletal Muscle upon Hypobaric Hypoxic Exposure. Front Physiol. 2016;7:303 pubmed publisher
    ..and lipid damage), mitochondrial potential variation, gene profile of HIF, and myogenic transcription factors (Pax7, MyoD, myogenin), and miRNA expression (miR-1, miR-133, miR-206)...
  46. Wang G, Chen E, Liang C, Liang J, Gao L, Chuai M, et al. Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo. Mol Neurobiol. 2018;55:3523-3536 pubmed publisher
    ..In this study, we found the co-location of Atg7 and Pax7+ neural crest cells in early chick embryo development...
  47. Pugh J, Faulkner S, Turner M, Nimmo M. Satellite cell response to concurrent resistance exercise and high-intensity interval training in sedentary, overweight/obese, middle-aged individuals. Eur J Appl Physiol. 2018;118:225-238 pubmed publisher
    ..from the vastus lateralis before and 96 h after the RE component to determine muscle fiber type-specific total (Pax7+ cells) and active (MyoD+ cells) satellite cell number using immunofluorescence microscopy...
  48. McDonald A, Kunz M, McLoon L. Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice. PLoS ONE. 2014;9:e86424 pubmed publisher
    ..As expected, over time het limb skeletal muscles displayed reduced central nucleation mirrored by a reduction in Pax7-positive cells, demonstrating a significant loss in regenerative potential...
  49. Farup J, De Lisio M, Rahbek S, Bjerre J, Vendelbo M, Boppart M, et al. Pericyte response to contraction mode-specific resistance exercise training in human skeletal muscle. J Appl Physiol (1985). 2015;119:1053-63 pubmed publisher
    ..pericytes may provide an alternative source of myogenic progenitors and/or secrete paracrine factors to induce Pax7(+) SC proliferation and differentiation...
  50. Jiang C, Wang J, Yue F, Kuang S. The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion. Dev Biol. 2016;409:16-25 pubmed publisher
    ..embryonic myogenesis, however, Bex1 is robustly expressed by myogenin(+) differentiating myoblasts, but not by Pax7(+) proliferating myoblasts...
  51. Zhang R, Judson R, Liu D, Kast J, Rossi F. The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration. Skelet Muscle. 2016;6:22 pubmed publisher
    ..G9a during development, we restricted the knockout within adult satellite cells by crossing Ehmt2 (floxed) mice to Pax7 (CreERT2) and also found normal muscle regeneration capacity...
  52. Petersen I, Wardelmann E. [Grading of soft tissue and bone sarcomas]. Pathologe. 2016;37:320-7 pubmed publisher
    ..relevance of gene expression signatures, the complexity index in sarcoma (CINSARC) and single genetic alterations (p53, MDM2, p16, SWI/SNF, EWSR1 fusions and PAX3/PAX7-FOXO1 fusions) for the prognosis of sarcomas are discussed.
  53. Blanc R, Vogel G, Li X, Yu Z, Li S, Richard S. Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate. Mol Cell Biol. 2017;37: pubmed publisher
    ..is a tightly regulated process controlled by a genetic cascade involving determinant transcription factors such as Pax7, Myf5, MyoD, and MyoG...
  54. Dumont N, Rudnicki M. Characterizing Satellite Cells and Myogenic Progenitors During Skeletal Muscle Regeneration. Methods Mol Biol. 2017;1560:179-188 pubmed publisher
    ..Several markers are used to identify the different myogenic populations, such as Pax7 (quiescent and activated satellite cells), MyoD (proliferating myoblasts), and myogenin (differentiating myoblasts)...
  55. Schafer B, Mattei M. The human paired domain gene PAX7 (Hup1) maps to chromosome 1p35-1p36.2. Genomics. 1993;17:249-51 pubmed
    The human PAX7 gene encodes a protein containing a domain homologous to the Drosophila paired box first described in three segmentation genes...
  56. Collins C, Gnocchi V, White R, Boldrin L, Perez Ruiz A, Relaix F, et al. Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation. PLoS ONE. 2009;4:e4475 pubmed publisher
    Pax3 and Pax7 are paired-box transcription factors with roles in developmental and adult regenerative myogenesis...
  57. Dearth C, Goh Q, Marino J, Cicinelli P, Torres Palsa M, Pierre P, et al. Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response. PLoS ONE. 2013;8:e58486 pubmed publisher
    ..Furthermore, expression of ICAM-1 altered (p<0.05) the temporal pattern of Pax7 expression, a marker of satellite cells/myoblasts, and regenerating myofiber formation in overloaded muscles...
  58. Joanisse S, McKay B, Nederveen J, Scribbans T, Gurd B, Gillen J, et al. Satellite cell activity, without expansion, after nonhypertrophic stimuli. Am J Physiol Regul Integr Comp Physiol. 2015;309:R1101-11 pubmed publisher
    ..Specifically, the number of activated (Pax7(+)/MyoD(+), P ≤ 0.05) and differentiating (Pax7(-)/MyoD(+), P ≤ 0...
  59. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, et al. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015;6:10068 pubmed publisher
    ..PTEN is localized to the nucleus in NSCs, binds to the PAX7 promoter through association with cAMP responsive element binding protein 1 (CREB)/CREB binding protein (CBP) and ..
  60. Morena D, Maestro N, Bersani F, Forni P, Lingua M, Foglizzo V, et al. Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes. elife. 2016;5: pubmed publisher
    ..In a Pax7 wild type background, HGF stimulation mainly causes ERMS that originate from satellite cells following a process of ..
  61. Helinska A, Krupa M, Archacka K, Czerwinska A, Streminska W, Janczyk Ilach K, et al. Myogenic potential of mouse embryonic stem cells lacking functional Pax7 tested in vitro by 5-azacitidine treatment and in vivo in regenerating skeletal muscle. Eur J Cell Biol. 2017;96:47-60 pubmed publisher
    ..Among the factors crucial for the specification of myogenic precursor cells is Pax7 that sustains proper function of satellite cells...
  62. Wu J, Hunt S, Xue H, Liu Y, Darabi R. Generation and validation of PAX7 reporter lines from human iPS cells using CRISPR/Cas9 technology. Stem Cell Res. 2016;16:220-8 pubmed publisher
    ..Here, we have generated a knock-in human iPS cell line for the early myogenic lineage specification gene of PAX7. By introduction of site-specific double-stranded breaks (DSB) in the genomic locus of PAX7 using CRISPR/Cas9 ..
  63. Karunamurthy A, Hoffner L, Hu J, Shaw P, Ranganathan S, Yatsenko S, et al. Genomic Characterization of a Metastatic Alveolar Rhabdomyosarcoma Case Using FISH Studies and CGH+SNP Microarray Revealing FOXO1-PAX7 Rearrangement with MYCN and MDM2 Amplification and RB1 Region Loss. Cytogenet Genome Res. 2016;150:253-261 pubmed publisher
    ..However, microarray analysis identified the essential FOXO1-PAX7 aberration and additional submicroscopic genomic alterations, including amplification of MYCN and MDM2 and deletion ..
  64. Jiao S, Tan X, Li M, Sui Y, Du S, You F. The duplicated paired box protein 7 (pax7) genes differentially transcribed during Japanese flounder (Paralichthys olivaceus) embryogenesis. Comp Biochem Physiol B Biochem Mol Biol. 2015;189:62-8 pubmed publisher
    ..Here, we identified six spliced isoforms of pax7a and one pax7b and characterized their expression patterns...
  65. Poniewierska Baran A, Suszynska M, Sun W, Abdelbaset Ismail A, Schneider G, Barr F, et al. Human rhabdomyosarcoma cells express functional erythropoietin receptor: Potential therapeutic implications. Int J Oncol. 2015;47:1989-97 pubmed publisher
    ..alveolar-type RMS cell lines and five embrional-type RMS cell lines), and mRNA samples obtained from positive, PAX7-FOXO1-positive, and fusion-negative RMS patient samples...
  66. Tian Z, Jiang S, Zhang M, Wang M, Li J, Zhao R, et al. α7nAChR is expressed in satellite cells at different myogenic status during skeletal muscle wound healing in rats. J Mol Histol. 2015;46:499-509 pubmed
    ..By morphometric analysis, the average number of α7nAChR+/Pax7+ and α7nAChR+/MyoD+ cells climaxed at 5 days post-injury...
  67. Carrió E, Magli A, Muñoz M, Peinado M, Perlingeiro R, Suelves M. Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation. BMC Biol. 2016;14:30 pubmed publisher
    ..genes orchestrating the myogenic determination and differentiation programs in embryonic stem (ES) cells, their Pax7-induced myogenic derivatives, and muscle stem cells in proliferating and differentiating conditions...
  68. Gowans L, Adeyemo W, Eshete M, Mossey P, Busch T, Aregbesola B, et al. Association Studies and Direct DNA Sequencing Implicate Genetic Susceptibility Loci in the Etiology of Nonsyndromic Orofacial Clefts in Sub-Saharan African Populations. J Dent Res. 2016;95:1245-56 pubmed publisher
    ..In meta-analyses of the case-control cohort, PAX7 (rs742071, P = 5.10 × 10(-3)), 8q24 (rs987525, P = 1.22 × 10(-3)), and VAX1 (rs7078160, P = 0...
  69. Sorensen P, Lynch J, Qualman S, Tirabosco R, Lim J, Maurer H, et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. J Clin Oncol. 2002;20:2672-9 pubmed
    ..Most ARMS patients express PAX3-FKHR or PAX7-FKHR gene fusions resulting from t(2;13) or t(1;13) translocations, respectively...
  70. Castiglioni A, Hettmer S, Lynes M, Rao T, Tchessalova D, Sinha I, et al. Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle. Stem Cell Reports. 2014;2:92-106 pubmed publisher
    ..We demonstrate that cells expressing the satellite cell marker PAX7 are highly enriched within the subset of CD45-CD11b-GlyA-CD31-CD34-..
  71. Monge C, DiStasio N, Rossi T, Sébastien M, Sakai H, Kalman B, et al. Quiescence of human muscle stem cells is favored by culture on natural biopolymeric films. Stem Cell Res Ther. 2017;8:104 pubmed publisher
    ..cells cultured in vitro on soft biopolymer films for 3 days maintained expression of the quiescence marker Pax7, as compared with 60% on stiffer films and 50% on tissue culture plastic...
  72. Banerji C, Panamarova M, Hebaishi H, White R, Relaix F, Severini S, et al. PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle. Nat Commun. 2017;8:2152 pubmed publisher
    ..b>PAX7 is a master regulator of myogenesis that rescues DUX4-mediated apoptosis...
  73. Mackey A, Rasmussen L, Kadi F, Schjerling P, Helmark I, Ponsot E, et al. Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication. FASEB J. 2016;30:2266-81 pubmed publisher
    ..PLA, 19 ± 2% (means ± sem)], satellite cell content at 7 d [IBU, 0.16 ± 0.01 vs. PLA, 0.12 ± 0.01 (Pax7(+) cells/fiber)], and to expedite muscle repair at 30 d...
  74. Lala Tabbert N, AlSudais H, Marchildon F, Fu D, Wiper Bergeron N. CCAAT/enhancer binding protein β is required for satellite cell self-renewal. Skelet Muscle. 2016;6:40 pubmed
    ..The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7+ satellite cells of healthy muscle and is downregulated during myoblast differentiation...
  75. Margue C, Bernasconi M, Barr F, Schafer B. Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene. 2000;19:2921-9 pubmed
    ..These results suggest that at least part of the anti-apoptotic effect of PAX3 and PAX3/FKHR is mediated through direct transcriptional modulation of the prominent anti-apoptotic protein BCL-XL. Oncogene (2000). ..
  76. Vorobyov E, Horst J. Expression of two protein isoforms of PAX7 is controlled by competing cleavage-polyadenylation and splicing. Gene. 2004;342:107-12 pubmed
    The PAX7 gene encodes an evolutionary conserved transcription factor that is involved in the determination of the myogenic cell lineage during the development of vertebrates...
  77. Vorobyov E, Horst J. Getting the proto-Pax by the tail. J Mol Evol. 2006;63:153-64 pubmed
    ..structure, PD-OP-PtHD-PHT, which has been retained in the extant proteins Pax3/7 of the ascidia and lancelet, and Pax7 of the vertebrates...
  78. Hanna J, Garcia M, Go J, Finkelstein D, Kodali K, Pagala V, et al. PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma. Cell Death Dis. 2016;7:e2256 pubmed publisher
    ..RMS (FP-RMS) or fusion-negative RMS (FN-RMS) based on the presence or absence of either PAX3-FOXO1 or PAX7-FOXO1 gene fusions...
  79. Wang C, Wang M, Arrington J, Shan T, Yue F, Nie Y, et al. Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors. Development. 2017;144:235-247 pubmed publisher
    ..During mouse development, Ascl2 is transiently detected in a subpopulation of Pax7+ MyoD+ progenitors (myoblasts) that become Pax7+ MyoD- satellite cells ..
  80. Stapleton P, Weith A, Urbanek P, Kozmik Z, Busslinger M. Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9. Nat Genet. 1993;3:292-8 pubmed
    ..PAX-1 and PAX-7 map to chromosomal regions containing previously assigned disease loci. ..
  81. Chang B, Pang L, Qi Y, Liu C, Cao Y, Li H, et al. PAX--FKHR fusion genes and AChR-gamma in Chinese patients with rhabdomyosarcoma: diagnosis using formalin-fixed archival tissues. Int J Surg Pathol. 2009;17:6-15 pubmed publisher
    ..PAX3 -FKHR and PAX7-FKHR transcripts were positive in 4/8 and 2/8 cases of ARMS, respectively...
  82. Butali A, Suzuki S, Cooper M, Mansilla A, Cuenco K, Leslie E, et al. Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P). Am J Med Genet A. 2013;161A:965-72 pubmed publisher
    ..To replicate two of these GWAS signals, we investigated the role of common and rare variants in the PAX7 and VAX1 genes...
  83. Hulin J, Nguyen T, Cui S, Marri S, Yu R, Downes M, et al. Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with ?-Catenin and Chromatin Remodelling. Stem Cells. 2016;34:2169-82 pubmed publisher
    ..We recently identified the Barx2 and Pax7 homeobox proteins as novel components of the Wnt effector complex...
  84. Charville G, Varma S, Forgo E, Dumont S, Zambrano E, Trent J, et al. PAX7 Expression in Rhabdomyosarcoma, Related Soft Tissue Tumors, and Small Round Blue Cell Neoplasms. Am J Surg Pathol. 2016;40:1305-15 pubmed publisher
    ..Here, we expand the toolkit for rhabdomyosarcoma diagnosis by studying the expression of PAX7, a transcriptional regulator of mammalian muscle progenitor cells implicated in the pathogenesis of ..
  85. Miller B, Hamilton K, Majeed Z, Abshire S, Confides A, Hayek A, et al. Enhanced skeletal muscle regrowth and remodelling in massaged and contralateral non-massaged hind limb. J Physiol. 2017;: pubmed publisher
    ..adhesion kinase (FAK) phosphorylation indicated that CCL increased mechanical stimulation, while a higher number of Pax7+ cells likely explains the elevated DNA synthesis...
  86. Summers M, Mikulec K, Peacock L, Little D, Schindeler A. Limitations of the Pax7-creERT2 transgene for driving deletion of Nf1 in adult mouse muscle. Int J Dev Biol. 2017;61:531-536 pubmed publisher
    ..of an inducible muscle-specific NF1 knockout strain (Nf1Pax7i f/f ) produced by cross breeding the Pax7-CreERT2 strain with the conditional Nf1flox/flox line...
  87. Shapiro D, Sublett J, Li B, Valentine M, Morris S, Noll M. The gene for PAX7, a member of the paired-box-containing genes, is localized on human chromosome arm 1p36. Genomics. 1993;17:767-9 pubmed
    ..By analysis of somatic cell hybrids segregating human chromosomes, the gene encoding PAX7 was localized to human chromosome 1...
  88. Kazanowska B, Reich A, Stegmaier S, Bekassy A, Leuschner I, Chybicka A, et al. Pax3-fkhr and pax7-fkhr fusion genes impact outcome of alveolar rhabdomyosarcoma in children. Fetal Pediatr Pathol. 2007;26:17-31 pubmed
    ..PAX3-FKHR fusion genes were detected in 28 and PAX7-FKHR fusion genes in 7 tumor biopsy specimens...
  89. McKinnell I, Ishibashi J, Le Grand F, Punch V, Addicks G, Greenblatt J, et al. Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex. Nat Cell Biol. 2008;10:77-84 pubmed
    ..The paired-box transcription factor Pax7 is required for satellite cells to generate committed myogenic progenitors...
  90. Bi P, Yue F, Sato Y, Wirbisky S, Liu W, Shan T, et al. Stage-specific effects of Notch activation during skeletal myogenesis. elife. 2016;5: pubmed publisher
    ..Specifically, constitutive Notch1 activation dedifferentiates myocytes into Pax7 quiescent satellite cells, leading to severe defects in muscle growth and regeneration, and postnatal lethality...
  91. Wanner R, Gey M, Abaei A, Warnecke D, de Roy L, Dürselen L, et al. Functional and Molecular Characterization of a Novel Traumatic Peripheral Nerve-Muscle Injury Model. Neuromolecular Med. 2017;19:357-374 pubmed publisher
    ..drop tower-inflicted facial nerve injury resulted in muscle damage, activation of muscle satellite cell markers (PAX7) and pronounced infiltration of immune cells to the injury site only in this model but not upon surgical nerve ..
  92. Wang R, Bhat Nakshatri P, Padua M, Prasad M, Anjanappa M, Jacobson M, et al. Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer. Mol Cancer Ther. 2017;16:2747-2758 pubmed publisher
    ..factor NF-?B could be central to this process, as it displays oncogenic functions and is integral to the Pax7:MyoD:Pgc-1?:miR-486 myogenesis axis...